Movement
The act, process, or result of passing from one place or position to another. It differs from LOCOMOTION in that locomotion is restricted to the passing of the whole body from one place to another, while movement encompasses both locomotion but also a change of the position of the whole body or any of its parts. Movement may be used with reference to humans, vertebrate and invertebrate animals, and microorganisms. Differentiate also from MOTOR ACTIVITY, movement associated with behavior.
Human Body
Substance P
Muscle, Skeletal
Muscle Proteins
Neuromuscular Diseases
Muscular Dystrophies
Muscular Dystrophy, Duchenne
An X-linked recessive muscle disease caused by an inability to synthesize DYSTROPHIN, which is involved with maintaining the integrity of the sarcolemma. Muscle fibers undergo a process that features degeneration and regeneration. Clinical manifestations include proximal weakness in the first few years of life, pseudohypertrophy, cardiomyopathy (see MYOCARDIAL DISEASES), and an increased incidence of impaired mentation. Becker muscular dystrophy is a closely related condition featuring a later onset of disease (usually adolescence) and a slowly progressive course. (Adams et al., Principles of Neurology, 6th ed, p1415)
Hospitals, Voluntary
Hospitals, Proprietary
Myotonic Dystrophy
Neuromuscular disorder characterized by PROGRESSIVE MUSCULAR ATROPHY; MYOTONIA, and various multisystem atrophies. Mild INTELLECTUAL DISABILITY may also occur. Abnormal TRINUCLEOTIDE REPEAT EXPANSION in the 3' UNTRANSLATED REGIONS of DMPK PROTEIN gene is associated with Myotonic Dystrophy 1. DNA REPEAT EXPANSION of zinc finger protein-9 gene intron is associated with Myotonic Dystrophy 2.
Muscular Dystrophy, Facioscapulohumeral
An autosomal dominant degenerative muscle disease characterized by slowly progressive weakness of the muscles of the face, upper-arm, and shoulder girdle. The onset of symptoms usually occurs in the first or second decade of life. Affected individuals usually present with impairment of upper extremity elevation. This tends to be followed by facial weakness, primarily involving the orbicularis oris and orbicularis oculi muscles. (Neuromuscul Disord 1997;7(1):55-62; Adams et al., Principles of Neurology, 6th ed, p1420)
Chromosomes, Human, Pair 4
Dystrophin
A muscle protein localized in surface membranes which is the product of the Duchenne/Becker muscular dystrophy gene. Individuals with Duchenne muscular dystrophy usually lack dystrophin completely while those with Becker muscular dystrophy have dystrophin of an altered size. It shares features with other cytoskeletal proteins such as SPECTRIN and alpha-actinin but the precise function of dystrophin is not clear. One possible role might be to preserve the integrity and alignment of the plasma membrane to the myofibrils during muscle contraction and relaxation. MW 400 kDa.
Muscular Atrophy, Spinal
A group of disorders marked by progressive degeneration of motor neurons in the spinal cord resulting in weakness and muscular atrophy, usually without evidence of injury to the corticospinal tracts. Diseases in this category include Werdnig-Hoffmann disease and later onset SPINAL MUSCULAR ATROPHIES OF CHILDHOOD, most of which are hereditary. (Adams et al., Principles of Neurology, 6th ed, p1089)
Spinal Muscular Atrophies of Childhood
A group of recessively inherited diseases that feature progressive muscular atrophy and hypotonia. They are classified as type I (Werdnig-Hoffman disease), type II (intermediate form), and type III (Kugelberg-Welander disease). Type I is fatal in infancy, type II has a late infantile onset and is associated with survival into the second or third decade. Type III has its onset in childhood, and is slowly progressive. (J Med Genet 1996 Apr:33(4):281-3)
Survival of Motor Neuron 1 Protein
A SMN complex protein that is essential for the function of the SMN protein complex. In humans the protein is encoded by a single gene found near the inversion telomere of a large inverted region of CHROMOSOME 5. Mutations in the gene coding for survival of motor neuron 1 protein may result in SPINAL MUSCULAR ATROPHIES OF CHILDHOOD.
SMN Complex Proteins
A complex of proteins that assemble the SNRNP CORE PROTEINS into a core structure that surrounds a highly conserved RNA sequence found in SMALL NUCLEAR RNA. They are found localized in the GEMINI OF COILED BODIES and in the CYTOPLASM. The SMN complex is named after the Survival of Motor Neuron Complex Protein 1, which is a critical component of the complex.
Survival of Motor Neuron 2 Protein
Huntington Disease
A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)
Atrophy
American Heart Association
Congresses as Topic
Toxic oil syndrome mortality: the first 13 years. (1/1572)
BACKGROUND: The toxic oil syndrome (TOS) epidemic that occurred in Spain in the spring of 1981 caused approximately 20000 cases of a new illness. Overall mortality and mortality by cause in this cohort through 1994 are described for the first time in this report. METHODS: We contacted, via mail or telephone, almost every living member of the cohort and family members of those who were known to have died in order to identify all deaths from 1 May 1981 through 31 December 1994. Cause of death data were collected from death certificates and underlying causes of death were coded using the International Classification of Diseases, 9th Revision. RESULTS: We identified 1663 deaths between 1 May 1981 and 31 December 1994 among 19 754 TOS cohort members, for a crude mortality rate of 8.4%. Mortality was highest during 1981, with a standardized mortality ratio (SMR) of 4.92 (95% confidence interval [CI]: 4.39-5.50) compared with the Spanish population as a whole. The highest SMR, (20.41, 95% CI: 15.97-25.71) was seen among women aged 20-39 years during the period from 1 May 1981 through 31 December 1982. Women <40 years old, who were affected by TOS , were at greater risk for death in most time periods than their unaffected peers, while older women and men were not. Over the follow-up period, mortality of the cohort was less than expected when compared with mortality of the general Spanish population, or with mortality of the population of the 14 provinces where the epidemic occurred. We also found that, except for deaths attributed to external causes including TOS and deaths due to pulmonary hypertension, all causes of death were decreased in TOS patients compared to the Spanish population. The most frequent underlying causes of death were TOS, 350 (21.1%); circulatory disorders, 536 (32.3%); and malignancies, 310 (18.7%). CONCLUSIONS: We conclude that while on average people affected by toxic oil syndrome are not at greater risk for death over the 13-year study period than any of the comparison groups, women <40 years old were at greater risk of death. (+info)Wasting of the small hand muscles in upper and mid-cervical cord lesions. (2/1572)
Four patients are described with destructive rheumatoid arthritis of the cervical spine and neurogenic wasting of forearm and hand muscles. The pathological connection is not immediately obvious, but a relationship between these two observations is described here with clinical, radiological, electrophysiological and necropsy findings. Compression of the anterior spinal artery at upper and mid-cervical levels is demonstrated to be the likely cause of changes lower in the spinal cord. These are shown to be due to the resulting ischaemia of the anterior part of the lower cervical spinal cord, with degeneration of the neurones innervating the forearm and hand muscles. These findings favour external compression of the anterior spinal artery leading to ischaemia in a watershed area as the likeliest explanation for this otherwise inappropriate and bizarre phenomenon. (+info)Obturator internus muscle abscess in children: report of seven cases and review. (3/1572)
Obturator internus muscle (OIM) abscess is an uncommon entity often mistaken for septic arthritis of the hip. We describe seven children with OIM abscess and review seven previously reported cases. The most common presenting symptoms were hip or thigh pain (14 patients), fever (13), and limp (13). The hip was flexed, abducted, and externally rotated in 11 patients. Magnetic resonance imaging and computed tomography (CT) were diagnostic for OIM abscess in the 14 patients. Associated abscesses were located in the obturator externus muscle (5 patients), psoas muscle (2), and iliac muscle (1). The etiologic agents were Staphylococcus aureus (8 patients), Streptococcus pyogenes (2), Neisseria gonorrhoeae (2), and Enterococcus faecalis (1). Three patients underwent CT-guided percutaneous drainage, and three had surgical drainage. Three patients had ischial osteomyelitis in addition to OIM abscess. The 11 children with uncomplicated OIM abscess were treated for a median of 28 days. All patients had an uneventful recovery. (+info)Autosomal dominant myopathy with proximal weakness and early respiratory muscle involvement maps to chromosome 2q. (4/1572)
Two Swedish families with autosomal dominant myopathy, who also had proximal weakness, early respiratory failure, and characteristic cytoplasmic bodies in the affected muscle biopsies, were screened for linkage by means of the human genome screening set (Cooperative Human Linkage Center Human Screening Set/Weber version 6). Most chromosome regions were completely excluded by linkage analysis (LOD score <-2). Linkage to the chromosomal region 2q24-q31 was established. A maximum combined two-point LOD score of 4.87 at a recombination fraction of 0 was obtained with marker D2S1245. Haplotype analysis indicated that the gene responsible for the disease is likely to be located in the 17-cM region between markers D2S2384 and D2S364. The affected individuals from these two families share an identical haplotype, which suggests a common origin. (+info)Weakness associated with the pathological presence of lipid in skeletal muscle: a detailed study of a patient with carnitine deficiencey. (5/1572)
A patient with muscular weakness demonstrating pathological lipid accumulation and abnormal mitochondria in skeletal muscle has been studied. The lipid accumulation and mitochondrial changes are thought to be related to the established deficiency of carnitine in this patient's muscle. The symptoms of muscular weakness associated with lipid accumulation in the skeletal muscle in the absence of complaint of muscle cramps or myglobinuria are thought to be diagnostic of carnitine deficiency. The failure of the sarcoplasmic reticulum to accumulate Ca2+ is discussed. The patient's strength responded dramatically when propranolol was added to his steroid therapy. (+info)Measurements of muscle strength and performance in children with normal and diseased muscle. (6/1572)
A study has been made of two simple means of measuring muscle power in children with normal and diseased muscle. In one the length of time that the leg and the head could be held at 45 degrees above the horizontal was measured with the child supine. In the second, measurements were made of the isometric strength of six muscle groups with the newly developed Hammersmith Myometer. In the timed performance tests only 5 (8%) of a group of 61 children known to have muscle disease achieved the minimum expected values for their ages. Myometer readings of the isometric power of the children with muscle disease also have values which were below those of a comparable group of normal children. The reproducibility of muscle strength measurements in young children has been shown to be good, whereas the timed performance tests, though able to differentiate normal children from children with muscle disease, did not show sufficient reporducibility for this test to be recommended for sequential measurements. (+info)Calcific myonecrosis. (7/1572)
Calcific myonecrosis is a rare and late sequela of compartment syndrome, which becomes symptomatic years after the initial trauma. We diagnosed this condition in a 64-year old man, 42 years after he sustained a shot-gun wound to the right lower leg. Total excision of a peripherally calcified, cystic mass, continuous with the anterior tibial muscle belly resulted in complete resolution of symptoms. Consideration of the diagnosis is warranted in patients with a history of major injury who develop a soft tissue mass in the traumatized compartment. The treatment of choice is marginal excision. (+info)The prevalence and CT appearance of the levator claviculae muscle: a normal variant not to be mistaken for an abnormality. (8/1572)
BACKGROUND AND PURPOSE: The levator claviculae muscle is an infrequently recognized variant in humans, occurring in 2% to 3% of the population, and has rarely been reported in the radiologic or anatomic literature. The importance of this muscle to radiologists is in distinguishing it from an abnormality; most commonly, cervical adenopathy. After discovering this muscle on the CT scans of two patients during routine clinical examinations, we conducted a study to determine the prevalence and appearance of the muscle on CT studies. METHODS: We evaluated 300 CT scans that adequately depicted the expected location of the muscle. The most superior level in which the muscle could be identified and the apparent location of insertion on the clavicle were recorded for all subjects in whom the muscle was detected. RESULTS: Seven levator claviculae muscles were identified in six subjects (2%). It was bilateral in one, on the left in four, and on the right in one. It was identified up to the level of the transverse process of C3 in all cases. The insertion was the middle third of the clavicle for two muscles and the lateral third of the clavicle for the remaining five muscles. CONCLUSION: Because the levator claviculae muscle will most likely be encountered during a radiologist's career, it is important to recognize this muscle as a variant and not as an abnormality. (+info)
Statin-Induced Myopathy
Diagnostic Criteria of Stevens et al for Critical Illness Myopathy (CIM) | Medicalalgorithms.com
Clinical Trial of CoQ10 for Mild-to-Moderate Statin-Associated Muscle Symptoms - Full Text View - ClinicalTrials.gov
Exome sequencing identifies titin mutations causing hereditary myopathy with early respiratory failure (HMERF) in families of...
Hereditary Proximal Myopathy with Early Respiratory Failure (HMERF): Symptoms, Diagnosis and Treatment - Symptoma
The Association of Genetic Polymorphisms With Statin-Induced Myopathy. - Full Text View - ClinicalTrials.gov
Progressive myopathy and defects in the maintenance of myotendinous junctions in mice that lack talin 1 in skeletal muscle |...
Altered sodium channel-protein associations in critical illness myopathy
Notes from Dr. RW: Statin myopathy
Histologische und biochemische Charakterisierung der autochthonen Rückenmuskulatur (M. erector spinae) bei neuromuskulär...
tight muscles - Symptoms, Treatments and Resources for tight muscles
The Relation of Alcoholic Myopathy to Cardiomyopathy | Annals of Internal Medicine | American College of Physicians
Hand symptoms and Long thin fingers and Muscle symptoms and Ocular weakness and Skin texture changes and Tooth deformity -...
Muscle symptoms and Oral pain and Face symptoms - Symptom Checker - check medical symptoms at RightDiagnosis
Annals of Indian Academy of Neurology: Table of Contents
Genetic Predisposition to Statin Myopathy | Spacedoc.com
Lipitor muscle symptoms
A Trigger for Muscular Diseases
Seeing an MFM on Thursday! - Welcome to the Preeclampsia Foundation
Drugs Used to Treat Bone and Muscle Disorders - Special Pet Topics - Merck Veterinary Manual
NMJ and muscle disorders Flashcards by Hiba Alhasso | Brainscape
Mahamasha thailam-Ayurvedic Oil for Neurological & Muscular Diseases | Ayurvedic Products
European outbreaks of atypical myopathy in grazing horses (2006-2009): Determination of indicators for risk and prognostic...
Myopathy, Distal 2 Symptoms, Diagnosis, Treatments and Causes - RightDiagnosis.com
Myopathy
myopathy
Video Surveillance Tests - Independent and In-Depth
Critical illness polyneuropathy-1 - Critical illness polyneuropathy Critical illness polyneuropathy From = Critical care...
Polysaccharide Storage Myopathy (PSSM) in Horses | Standlee Forage
ICD-10 Diagnosis Code G62.81 Critical illness polyneuropathy
Notes from Dr. RW: Neurologic complications of critical illness
Similar papers for Myotilinopathy: refining the clinical and myopathological phenotype. - Semantic Scholar
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Polysaccharide Storage Myopathy (PSSM)
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Assessment of mitochondrial oxidative phosphorylation in patient muscle biopsies, lymphoblasts, and transmitochondrial cell...
What are the probable congenital myopathies?
Statin-Associated Autoimmune Myopathy | Iranian Neurological Association
Credible Evidence: Anthony Colpo answers a question on Lipitor etc.
Anew mitochondria-related disease showing myopathy with episodic hyper-creatine kinase-emia.
Online USA Pharmacy: Antinuclear antibody and prednisone registered shipping!
Sensitivity of Troponin - American College of Cardiology
Accumulation of Abnormal Mitochondria Causes & Reasons - Symptoma
Myofibrillar Myopathy And Weight Loss
Symptoms and signs of Hyperthyroidism
Linkage to 18qter differentiates two clinically overlapping syndromes: congenital cataracts-facial dysmorphism-neuropathy ...
GNE Myopathy and Cell Apoptosis: A Comparative Mutation Analysis | SpringerLink
Search Results - SPS - Specialist Pharmacy Service - The first stop for professional medicines advice
Severe muscle stiffness, pain, headaches, fatigue, & jaw tightness, spasms - Muscle Symptoms - Symptom | Our Health
Myofibrillar Myopathy disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials
Myopathy Treatment - Myopathies - HealthCommunities.com
Calf numbness and Weak and soft muscles - Symptom Checker - check medical symptoms at RightDiagnosis
Anatomy | Key To Good Health
Most recent papers with the keyword advance directive issues | Read by QxMD
2d7p - Proteopedia, life in 3D
Study Found L- carnitine Can Heal Injured Heart Muscles | Muscular Disorders discussions | Body & Health Conditions center |...
muscle - Musculoskeletal vs. muscular disorders - Medical Sciences Stack Exchange
Incidence and Management of Exertional Rhabdomyolysis | TheHorse.com
Two New Mutations in Mitochondria DNA Associated with Isolated Myopathy
Section 3. Nerve and Muscle Disorders | Harrisons Principles of Internal Medicine, 18e | AccessPharmacy | McGraw-Hill Medical
Muscle Pain and Weakness in Thyroid Disease
Buy Skelaxin Online | Best Canadian Pharmacy
Muscle-Related Statin Effects Seem to Correlate With Potency - MPR
Muscle Diseases
What Is Causing This Womans Severe Muscle Pain? - The New York Times
Muscle Conditions
CoQ10 for Cardiovascular Disease | ISCMR
Cholesterol Drug & Muscle Pain - Share The Wealth
Managing lipids
How is Muscle Damage Repaired? (with pictures)
Muscle soreness or more serious? | SaukValley.com
Lactate dehydrogenase
"Diseases - Metabolic Diseases - Causes/Inheritance". Muscular Dystrophy Association. Retrieved 2016-03-02.. ... "Glycogen storage disease XI - Conditions - GTR - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2016-03-02.. ... Role in muscular fatigue[edit]. The onset of acidosis during periods of intense exercise is commonly attributed to accumulation ... Mutations of the M subunit have been linked to the rare disease exertional myoglobinuria (see OMIM article), and mutations of ...
Retinitis pigmentosa
... including muscular dystrophy and chronic granulomatous disease) as part of McLeod syndrome. This is an X-linked recessive ... Rivolta, C.; Sharon, D; Deangelis, M. M.; Dryja, T. P. (2002). "Retinitis pigmentosa and allied diseases: Numerous diseases, ... "Orphanet Journal of Rare Diseases. 1: 40. doi:10.1186/1750-1172-1-40. PMC 1621055. PMID 17032466.. ... Other conditions include neurosyphilis, toxoplasmosis and Refsum's disease. Genetics[edit]. Retinitis pigmentosa (RP) is one of ...
Familial partial lipodystrophy
There is an increased risk of coronary heart disease. Cardiomyopathy and muscular dystrophy may occur rarely. Xanthoma and nail ... Calf muscular hypertrophy may occur. Type 5 is due to mutations in the AKT2 gene. It has been reported in four patients all ... 2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0. Herbst KL, Tannock LR, Deeb ...
Analgesic
Muscular and rheumatic diseases.. As per diclofenac. Salol. No data.. As per diclofenac.. PO, topical.. No data.. Lower urinary ... Medical cannabis, or medical marijuana, refers to cannabis or its cannabinoids used to treat disease or improve symptoms.[21][ ... A reappraisal of its pharmacology, and therapeutic use in rheumatic diseases and pain states". Drugs. 40 (1): 91-137. doi: ... A reappraisal of its pharmacology and therapeutic use in rheumatic diseases and pain states". Drugs. 42 (2): 274-99. doi: ...
LMNA - 维基百科,自由的百科全书
Mutations in the LMNA gene are associated with several diseases, including Emery-Dreifuss muscular dystrophy, familial partial ... The nuclear envelope in muscular dystrophy and cardiovascular diseases. Traffic. 2002, 2 (10): 675-83. PMID 11576443. doi: ... The A-type lamins: nuclear structural proteins as a focus for muscular dystrophy and cardiovascular diseases. Trends Cardiovasc ... Dense Deposit Disease/Membranoproliferative Glomerulonephritis Type II. 19 May 2011. PMID 20301598. NBK1425.. In GeneReviews ...
Lisa Welander
In 1951 Welander was the first to describe the hereditary muscular disease Welander's distal myopathy, a type of distal ... doi:10.1159/000150998 Welander, L. (1961). Genetic research in muscular diseases in Sweden. In Proceeding df the Second ... Kugelberg, E., Welander, L. (1956). "Heredofamilial juvenile muscular atrophy simulating muscular dystrophy". Archives of ... The juvenile manifestation of the disease SMA type III is named after her and her colleague Kugelberg-Welander disease. ...
Hereditary inclusion body myopathy
Other Names: IBMPFD; Inclusion body myopathy with Paget disease of bone and frontotemporal dementia; Limb-girdle muscular ... Molecular Basis of Disease. Genetic Glycosylation Diseases. 1792 (9): 881-887. doi:10.1016/j.bbadis.2009.07.001. PMC 2748147. ... "Inclusion body myopathy with early-onset Paget disease and frontotemporal dementia". NIH - Genetic and Rare Diseases ... Disease occurs when both copies in the genome are non functional. The pathophysiology is still unclear. Cardiac involvement may ...
LMNA
Mutations in the LMNA gene are associated with several diseases, including Emery-Dreifuss muscular dystrophy, familial partial ... Burke B, Mounkes LC, Stewart CL (2002). "The nuclear envelope in muscular dystrophy and cardiovascular diseases". Traffic. 2 ( ... nuclear structural proteins as a focus for muscular dystrophy and cardiovascular diseases". Trends Cardiovasc. Med. 11 (7): 280 ... Burke B, Stewart CL (2002). "Life at the edge: the nuclear envelope and human disease". Nat. Rev. Mol. Cell Biol. 3 (8): 575-85 ...
Lewis Rowland
Houston Merritt Clinical Research Center for Muscular Dystrophy and Related Diseases as well as the Eleanor and Lou Gehrig ALS ... also known as Lou Gehrig's disease), and muscular dystrophy. He was chair of the neurology department at Columbia University ... Lewis Rowland, Leading Neurologist on Nerve and Muscle Diseases, Dies at 91". The New York Times. Gooch, Clifton; Weimer, Louis ...
Jean-Martin Charcot
The disease is also sometimes called peroneal muscular atrophy. Charcot's studies between 1868 and 1881 were a landmark in the ... the most-common subtype of motor neurone disease-also known as Lou Gehrig's disease.) Charcot-Marie-Tooth disease (peripheral ... We eliminate and ignore everything that is not a part of our prejudices." "To learn how to treat a disease, one must learn how ... "Charcot-Marie-Tooth disease". Whonamedit.com. Archived from the original on 14 May 2011. Retrieved 16 October 2008. Lees AJ ( ...
Heart failure
In congenital diseases such as Duchenne muscular dystrophy, the molecular structure of individual myocytes is affected. ... kidney diseases, chronic severe anemia, beriberi (vitamin B1/thiamine deficiency), hyperthyroidism, cirrhosis, Paget's disease ... Criteria Committee, New York Heart Association (1964). Diseases of the heart and blood vessels. Nomenclature and criteria for ... Tamparo, Carol (2011). Fifth Edition: Diseases of the Human Body. Philadelphia, PA: F.A. Davis Company. p. 329. ISBN 978-0-8036 ...
Horse colic
Thickness of the intestinal walls may indicate infiltrative disease or abnormal muscular enlargement. Roughening of the serosal ... However, it can be useful in cases of suspected intestinal cancer, as well as some inflammatory diseases (such as IBD) and ... The mucosa remains normal, so malabsorption is not expected to occur in this disease. Ileal hypertrophy may be idiopathic, with ... Capillary refill time (CRT) may be decreased early in the colic, but generally prolongs as the disease progresses and ...
Ludvig Strigeus
Due to a rare muscular disease, Strigeus uses a wheelchair. μTorrent - small footprint BitTorrent client for Microsoft Windows ...
Thomas A. Rando
Rando's group has developed mouse models of muscular dystrophy that allow the assessment of disease progression non-invasively ... Maguire, Katie K.; Lim, Leland; Speedy, Sedona; Rando, Thomas A. (May 2013). "Assessment of disease activity in muscular ... "Monitoring disease activity noninvasively in the mdx model of Duchenne muscular dystrophy". Proceedings of the National Academy ... Rando's group has also contributed to the field of stem cell therapeutics for injury and disease by combining basic stem cell ...
Camptocormia
Some examples of diseases that have secondary BSS as a symptom are myopathies caused by muscular dystrophies, neuromuscular ... Muscular origin[edit]. Myopathic origin BSS can be secondary to various muscular disorders or occur as a primary idiopathy.[2] ... BSS often appears in individuals afflicted with Parkinson's disease, muscular dystrophies, endocrine disorders, inflammatory ... such as muscular weakness and neurological disorders like Parkinson's disease. While BSS doesn't have any negative stigma in ...
Orphan drug
Thomas, Katie (30 December 2016). "Costly Drug for Fatal Muscular Disease Wins F.D.A. Approval". The New York Times. Retrieved ... The conditions are referred to as orphan diseases. The assignment of orphan status to a disease and to drugs developed to treat ... Penicillamine was developed to treat Wilson's disease, a rare hereditary disease that can lead to a fatal accumulation of ... NICE 2014 Rare disease Drug development European Organization for Rare Diseases Supplementary protection certificate Armstrong ...
Orthopedic pathology
Common examples of degenerative diseases are Parkinson's disease and Muscular Dystrophy. Musculoskeletal disorders (or MSDs) ... Paget's disease of the bone and soft-tissue injuries. Bone diseases include non-neoplastic disorders, which are diseases that ... These consist of genetic diseases, osteoporosis, infections of the bone, and Paget's disease of bone. Neuromotor impairments ... legs and pelvis Sarcoma of Paget's disease of the bone occurs in people that already have Paget's disease, mainly aged above 70 ...
Hereditary motor and sensory neuropathy
Dyck, Peter James; Lambert, Edward H. (1968). "Lower Motor and Primary Sensory Neuron Diseases With Peroneal Muscular Atrophy ... The disease can be inherited in an autosomal dominant, autosomal recessive or X-linked manner. Patients with hereditary motor ... Charcot-Marie-Tooth disease was first described in 1886 by Jean-Martin Charcot, Pierre Marie, and independently Howard Henry ... However, the majority of people with these diseases are able to walk and be self-sufficient. Some methods of relief for the ...
Anti-MAG peripheral neuropathy
People with this disease have shown many sensory and muscular symptoms. Most patients have a sensory ataxia, or sensory loss in ... More severe symptoms occur after the disease progresses and there is much more damage to the myelin sheaths in the peripheral ... It is used to treat various immune deficiencies and autoimmune diseases. While this has been shown to be effective on various ... This drug has been used as a treatment in many autoimmune diseases as well as lymphomas and transplant rejection. Because of ...
Ronald Sukenick
He died from the muscular disease inclusion body myositis, in 2004. A Wallace Stevens Handbook. Brandeis University. 1962. ...
Myopathy
Muscular disease can be classified as neuromuscular or musculoskeletal in nature. Some conditions, such as myositis, can be ... In medicine, myopathy is a disease of the muscle in which the muscle fibers do not function properly. This results in muscular ... Myopathies in systemic disease results from several different disease processes including endocrine, inflammatory, ... Myopathy means muscle disease (Greek : myo- muscle + patheia -pathy : suffering). This meaning implies that the primary defect ...
Tonicity
For the muscular disease, see Hypotonia.. This article needs additional citations for verification. Please help improve this ...
Follistatin
"Delivery of recombinant follistatin lessens disease severity in a mouse model of Spinal Muscular Atrophy". Hum. Mol. Genet. 18 ... A study has also shown that increased levels of follistatin, by leading to increased muscle mass of certain core muscular ... though there is debate as to its direct role in this infertility disease. GRCh38: Ensembl release 89: ENSG00000134363 - Ensembl ... groups, can increase life expectancy in cases of spinal muscular atrophy (SMA) in animal models. It is also being investigated ...
Christian Friedrich von Kahlbutz
Possible diseases that he suffered from are cancer, muscular dystrophy, and tuberculosis. There is evidence that he did in fact ...
Margaret W. Thompson
The History of a Genetic Disease: Duchenne Muscular Dystrophy Or Meryon's Disease. (1996). Trends in Genetics 12 (3): 119. ... Heredity, Maternal Age, and Birth Order in the Etiology of Celiac Disease. (1951). American Journal of Human Genetics 3 (2): ...
Osteopontin
A recent study has identified osteopontin as a determinant of disease severity in patients with Duchenne muscular dystrophy. ... OPN has been found to play a role in other autoimmune diseases including autoimmune hepatitis, allergic airway disease, and ... "SPP1 genotype is a determinant of disease severity in Duchenne muscular dystrophy". Neurology. 76 (3): 219-226. doi:10.1212/WNL ... Opn is up-regulated in inflammatory bowel disease (IBD). Opn expression is highly up-regulated in intestinal immune and non- ...
Kit Klein
Wilson died from a progressive muscular disease at 23. The Jean Wilson Memorial Trophy was created in her honor. Over the ...
LDB3
Mutations in the ZASP gene has been associated with several muscular diseases. ZASP is a PDZ domain-containing protein. PDZ ... Selcen D, Engel AG (Feb 2005). "Mutations in ZASP define a novel form of muscular dystrophy in humans". Annals of Neurology. 57 ... and muscular dystrophy. The PDZ domain of ZASP binds the C-terminus of alpha actinin-2 and ZMs bind the rod domain of alpha ... "eroing in on the role of Cypher in striated muscle function, signaling, and human disease". Trends in Cardiovascular Medicine ...
Atrophy
ALS or Lou Gehrig's disease), and Guillain-Barré syndrome. Examples of atrophying muscle diseases include muscular dystrophy, ... There are many diseases and conditions which cause atrophy of muscle mass. For example, diseases such as cancer and AIDS induce ... When it occurs as a result of disease or loss of trophic support because of other diseases, it is termed pathological atrophy, ... Pathologic atrophy of muscles can occur with diseases of the motor nerves or diseases of the muscle tissue itself. Examples of ...
Ferlins
Mutations in ferlins can cause human diseases such as muscular dystrophy and deafness. Abnormalities in expression of myoferlin ... The most important disease relevance of ferlins in humans is related to mutations in dysferlin. In humans, disease causing ... There is less known about FerA and DysF domains, however, mutations of these domains in dysferlin can also lead to muscular ... As in other mammals, there are six ferlin genes in humans (Fer1L1-Fer1L6). Among them, Fer1L1-Fer1L3 have known disease ...
Marsh Arabs
Of the men Keppel wrote, "The Arab boatmen were as hardy and muscular-looking fellows as ever I saw. One loose brown shirt, of ... The marsh environment meant that certain diseases, such as schistosomiasis and malaria, were endemic;[12] Maʻdānī agriculture ...
Ebola
Infectious disease. Symptoms. Fever, sore throat, muscular pain, headaches, diarrhoea, bleeding[1]. ... "Ebola Virus Disease". SRHD. Retrieved 15 September 2020.. *^ a b c d "Q&A on Transmission, Ebola". Centers for Disease Control ... "About Ebola Virus Disease". Centers for Disease Control and Prevention (CDC). Archived from the original on 16 October 2014. ... "Ebola (Ebola Virus Disease) Transmission". Centers for Disease Control and Prevention (CDC). 5 November 2014. Archived from the ...
Octopus
Coccidians in the genus Aggregata living in the gut cause severe disease to the host. Octopuses have an innate immune system, ... The systemic heart has muscular contractile walls and consists of a single ventricle and two atria, one for each side of the ... The diseases and parasites that affect octopuses have been little studied, but cephalopods are known to be the intermediate or ... The mantle cavity has muscular walls and contains the gills; it is connected to the exterior by a funnel or siphon.[22][26] The ...
Feces
"Microbial Ecology in Health and Disease. 30 (sup1): 1535737. doi:10.1080/16512235.2018.1535737. PMC 6225515. PMID 30425610.. ... The forces required to expel the feces are generated through muscular contractions and a build-up of gases inside the gut, ... Stokstad, Erik (28 July 2000). "Divining Diet and Disease From DNA". Science. 289 (5479): 530-531. doi:10.1126/science.289.5479 ... "Evidence that disgust evolved to protect from risk of disease". Proc. Biol. Sci. 271 Suppl 4 (Suppl 4): S131-3. doi:10.1098/ ...
Coffin-Lowry syndrome
Muscular spasticity. Stiff muscles. Most common. Less common. Muscle relaxers Loss of muscle strength. Paraplegia or partial ... Symptoms of disease are more severe in males, who are generally diagnosed in early childhood. Children afflicted by CLS display ... The prevalence of CLS is uncertain due to the rarity of the disease, but CLS is estimated to affect between 1 in 50,000 and 1 ... In 20-30% of cases, however, there is a family history of disease. In these cases, the disorder is typically inherited from the ...
Wheelchair
... people with some muscle diseases, and people with limited range of motion in the hip or knee joints.[10] Tilting options are ... and the role of the smart wheelchair is to interpret small muscular activations as high-level commands and execute them. Such ...
Reptile
Paterson, Sue (December 17, 2007). Skin Diseases of Exotic Pets. Blackwell Science, Ltd. pp. 74-79. ISBN 9780470752432. .. ... This is made possible by a muscular ridge that subdivides the ventricle during ventricular diastole and completely divides it ... Crocodilians actually have a muscular diaphragm that is analogous to the mammalian diaphragm. The difference is that the ... Hellebuyck, Tom; Pasmans, Frank; Haesbrouck, Freddy; Martel, An (July 2012). "Dermatological Diseases in Lizards". The ...
Moclobemide
Heinonen EH, Myllylä V (July 1998). "Safety of selegiline (deprenyl) in the treatment of Parkinson's disease". Drug Saf. 19 (1 ... Reversible MAOIs such as moclobemide may have advantages in the treatment of depression associated with Alzheimer's disease due ... Tikal K, Hrabánková M (June 1993). "[Indications for antidepressive agents in relation to diseases of the cardiovascular system ... a reversible selective monoamine oxidase A inhibitor in Parkinson's disease". J Clin Psychopharmacol. 15 (4 Suppl 2): 51S-59S. ...
Infantile progressive bulbar palsy
The disease exists in both rapid and slow onsets, and involves inflammation of the gray matter of the bulb.[1] Infantile PBP is ... Progressive muscular atrophy. *Progressive bulbar palsy *Fazio-Londe. *Infantile progressive bulbar palsy ... Wilson, John Eastman (1909). Diseases of the nervous system. Boericke & Runyon. p. 296. Retrieved 5 December 2017. Infantile ... a disease that manifests itself in two forms: Fazio Londe syndrome (FL) and Brown-Vialetto-Van-Laere syndrome (BVVL).[2] ...
Bioarchaeology
Enamel hypoplasias generally form due to disease and/or poor nutrition. Linear furrows are commonly referred to as linear ... and muscular arms and legs among female skeletons at Abu Hureyra. She interpreted this sex-based pattern of skeletal difference ... For example, bioarchaeologists have used caries in skeletons to correlate a diet of rice and agriculture with the disease. ... Disruptions in homeostasis caused by nutritional deficiency or disease or profound inactivity/disuse/disability can lead to ...
اختلالات حرکتی - ویکیپدیا، دانشنامهٔ آزاد
Baizabal-Carvallo, JF; Jankovic J. (2012-07-18). "Movement disorders in autoimmune diseases". Movement disorders : official ... Progressive muscular atrophy. *Progressive bulbar palsy *Fazio-Londe. *Infantile progressive bulbar palsy ...
Cyanotoxin
Parkinson's Disease and Alzheimer's Disease.[3] There is also an interest in the military potential of biological neurotoxins ... Stimulation of these receptors causes a muscular contraction. The anatoxin-a molecule is shaped so it fits this receptor, and ... "Neurobiology of Disease. 25 (2): 360-366. doi:10.1016/j.nbd.2006.10.002. PMC 3959771. PMID 17098435.. ... Byth S (July 1980). "Palm Island mystery disease". The Medical Journal of Australia. 2 (1): 40, 42. PMID 7432268.. ...
Cold Spring Harbor Laboratory
In 2014, Phase 3 trials begin for drug to treat spinal muscular atrophy (SMA), a neurodegenerative disease, based on Adrian ... Adrian Krainer, studies RNA splicing and developed nusinersen for treatment of spinal muscular atrophy (SMA). ... small subset of protein-coding genes within the much larger genome-now a mainstay of identifying genetic mutations in disease;[ ...
Arachnid - Simple English Wikipedia, the free encyclopedia
Behind the mouth is a muscular, pharynx, which acts as a pump, sucking the food through the mouth and on into the oesophagus ... Several mites are external parasites, and some of them are carriers of disease (vectors). ...
Eccentric training
Add to these factors disease and cardiac and respiratory illness. Eccentric training enables the elderly, and those with the ... and muscular strengthening. ... training in patients with chronic obstructive pulmonary disease ... Journal of Chronic Obstructive Pulmonary Disease. 8 (4): 270-274. doi:10.3109/15412555.2011.579926. PMID 21728805. S2CID ...
Familial amyloid polyneuropathy
... or Corino de Andrade's disease,[1] is an autosomal dominant[2] neurodegenerative disease. It is a form of amyloidosis, and was ... Usually manifesting itself between 20 and 40 years of age, it is characterized by pain, paresthesia, muscular weakness and ... "Rare-Disease Treatment From Alnylam to Cost $450,000 a Year". www.bloomberg.com. Retrieved 11 August 2018.. ... This disease is endemic in Portuguese locations Póvoa de Varzim and Vila do Conde (Caxinas), with more than 1000 affected ...
Obstructive sleep apnea
"Journal of Thoracic Disease. 7 (8): 1311-1322. doi:10.3978/j.issn.2072-1439.2015.06.11. PMC 4561280. PMID 26380759.. ... The permanent premature muscular tonal loss in the upper airway may be precipitated by traumatic brain injury, neuromuscular ... Stroke and other cardiovascular disease are related to OSA and those under the age of 70 have an increased risk of early death. ... OSA accompanied by daytime sleepiness is estimated to affect 3% to 7% of men and 2% to 5% of women, and the disease is common ...
Clitoridectomy
The Wages of Sin: Sex and Disease, Past and Present. University of Chicago Press, 2000, p. 106. *For the obituary, see J.F.C. " ... If the malignancy is present in muscular tissue in the region, it is also removed. In some cases, the surgeon is able to ...
Anxiety
... celiac disease, non-celiac gluten sensitivity, inflammatory bowel disease),[73][74][75] heart diseases, blood diseases (anemia ... It is often accompanied by muscular tension,[3] restlessness, fatigue and problems in concentration. Anxiety can be appropriate ... Parkinson's disease, dementia, multiple sclerosis, Huntington's disease), among others.[7][76][77][78] ... Furthermore, certain organic diseases may present with anxiety or symptoms that mimic anxiety.[6][7] These disorders include ...
Pelger-Huet anomaly
It has also been described in Filovirus disease.[4]. In patients with these conditions, the pseudo-Pelger-Huët cells tend to ... muscular dystrophy, leukemoid reaction secondary to metastases to the bone marrow, and drug sensitivity, sulfa and valproate ... "Outbreake of Marburg virus disease in Johannesburg". British Medical Journal. 4 (5995): 489-93. doi:10.1136/bmj.4.5995.489 ... appear late in the disease and often appear after considerable chemotherapy has been administered. The morphologic changes have ...
Kallmann syndrome
"Orphanet Journal of Rare Diseases. 6 (Jun 17): 41. doi:10.1186/1750-1172-6-41. PMC 3143089. PMID 21682876.. ... Androgen insensitivity syndrome/Spinal and bulbar muscular atrophy. *KAL1 Kallmann syndrome. *X-linked adrenal hypoplasia ... "Rare Diseases. National Organisation for Rare Disorders (NORD). 2012. Retrieved December 16, 2017.. ... Genetic and Rare Diseases Information. June 26, 2016. Retrieved December 17, 2017.. .mw-parser-output cite.citation{font-style: ...
Amyotrophic lateral sclerosis
... spinal muscular atrophy, and spinal and bulbar muscular atrophy can also mimic certain aspects of the disease and should be ... Disease Primers. 3 (17071): 17071. doi:10.1038/nrdp.2017.71. PMID 28980624.. *^ a b c d e f g h i j k l m n o p q r s t u v van ... Amyotrophic lateral sclerosis (ALS), also known as motor neurone disease (MND) or Lou Gehrig's disease, is a specific disease ... Other names for ALS include Charcot's disease, Lou Gehrig's disease, and motor neurone disease.[1] Amyotrophic comes from the ...
Proteasome
Huntington's disease,[126] Creutzfeldt-Jakob disease,[128] and motor neuron diseases, polyglutamine (PolyQ) diseases, muscular ... including Alzheimer's disease,[125] Parkinson's disease[126] and Pick's disease,[127] amyotrophic lateral sclerosis (ALS),[127] ... Increased levels of proteasome activity correlate with disease activity and have been implicated in autoimmune diseases ... cardiovascular diseases,[120][121][122] inflammatory responses and autoimmune diseases,[123] and systemic DNA damage responses ...
Beta-amiloide, a enciclopedia libre
Citron M (September 2004). "Strategies for disease modification in Alzheimer's disease". Nat. Rev. Neurosci. 5 (9): 677-85. ... unha enfermidade muscular), pero o Aβ pode tamén formar agregados que cobren os vasos sanguíneos cerebrais na anxiopatía ... "The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide". PLoS ONE 5 (3): e9505. Bibcode:2010PLoSO... ... Implications for the role of amyloid-beta 1-42 in Alzheimer's disease". J. Biol. Chem. 271 (50): 32185-91. PMID 8943274. doi: ...
Vocal cord cyst
Bohlender, Jörg (2013). "Diagnostic and therapeutic pitfalls in benign vocal fold diseases". GMS Current Topics in ... The increased mass and stiffness tends to result in hyperkinetic muscular movement during phonation.[9] Hyperkinetic movement ... Diagnostic and therapeutic pitfalls in benign vocal fold diseases". Gms Current Topics in Otorhinolaryngology, Head and Neck ...
Bernarr Macfadden
America: How Muscular Millionaire Bernarr Macfadden Transformed the Nation Through Sex, Salad, and the Ultimate Starvation Diet ... Walking Cure, Pep and Power from Walking - How to Cure Disease. 1924.. ... He claimed that "a person could exercise unqualified control over virtually all types of disease while revealing a degree of ... cultists that oppose scientific medicine and devote themselves to the promotion of some single conception of disease causation ...
Muscle - Simple English Wikipedia, the free encyclopedia
There are many different kinds of muscle diseases. There are three big groups of diseases: *Neuromuscular diseases - these are ... Muscular dystrophy, cancers like Ewing's sarcoma, and cardiomyopathy are myopathies.. Related pages[change , change source]. * ... Strokes, cerebral palsy, and Parkinson's disease are neuromuscular diseases.. *Motor endplate diseases - these are problems ... Tetanus and myasthenia gravis are motor endplate diseases.. *Myopathies - these are problems with the structure of the muscle. ...
Sleep disorder
"Journal of Nervous & Mental Disease. 179 (4): 181-241.. *^ Owens, Laurence J; France, Karyn G; Wiggs, Luci (1999). "REVIEW ... Progressive muscular atrophy. *Progressive bulbar palsy *Fazio-Londe. *Infantile progressive bulbar palsy ... It is neither a disease nor a specific condition. (from p. 322). CS1 maint: Extra text: editors list (link) ... Idiopathic hypersomnia: a chronic neurological disease similar to narcolepsy in which there is an increased amount of fatigue ...
Muscular System: Facts, Functions & Diseases
Diseases of the muscular system. There is no single type of doctor that treats muscular diseases and disorders. Rheumatologists ... Latest on Muscular System: Facts, Functions & Diseases. * Lymphatic System: Facts, Functions & Diseases ... Muscular System: Facts, Functions & Diseases. By Kim Ann Zimmermann, Live Science Contributor , March 11, 2016 07:35pm ET. ... The most recognizable motor neuron disease is amyotrophic lateral sclerosis, or ALS, commonly known as Lou Gehrigs disease. ...
Search of: 'Muscular Diseases' - List Results - ClinicalTrials.gov
Change in disease severity and disease progression. 48. All. Child, Adult, Senior. NCT02057705. VAL-101-13. MTM. February 2014 ... Contractile Cross Sectional Areas and Muscle Strength in Patients With Inherited Muscle Diseases. *Inherited Muscle Diseases ... Identification of Factors Associated With Physical Activity Levels in Adult Muscle Diseases. *Muscle Disease ... Toxicity;Survival;Disease improvement defined by muscle strength (one or more in MRC scale) and improvement of muscle derived ...
The nuclear envelope in muscular dystrophy and cardiovascular diseases. - PubMed - NCBI
The nuclear envelope in muscular dystrophy and cardiovascular diseases.. Burke B1, Mounkes LC, Stewart CL. ... Certain of these diseases are associated with nuclear structural abnormalities that can be seen in a variety of cells and ... limb girdle muscular dystrophy 1B with atrioventricular conduction disturbances, and Dunnigan-type familial partial ... include both X-linked and autosomal dominant forms of Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy with conduction ...
ASU Researchers Discover New Path To Address Genetic Muscular Diseases - Redorbit
... genetic muscular diseases such as muscular dystrophy and ALS, also called Lou Gehrigs disease. Now, an interdisciplinary team ... ASU Researchers Discover New Path To Address Genetic Muscular Diseases. by editor ... while promoting muscle growth in patients with muscular dystrophy," said Alan Rawls, associate professor with the School of ... linked nature of the two opposing processes of growth and atrophy and opens new avenues to pursue treatments of muscle diseases ...
List of Muscular System Diseases | LIVESTRONG.COM
... muscle weakness and paralysis can be signs of serious muscular problems. MedlinePlus says that muscle disorders can occur as a ... According to the NINDS, mitochondrial myopathies refer to a neuromuscular disease in which there is damage to the mitochondria. ... Muscle pain, muscle weakness and paralysis can be signs of serious muscular problems. MedlinePlus says that muscle disorders ...
muscular skeletal chest pains - Heart Disease - MedHelp
Can Mental Stress Lead to Heart Disease? Can depression and anxiety cause heart disease? Get the facts in this Missouri ... of heart disease? Why did I not experience any sort of breathlessness once in the last month? Why was my performance on the ... Heart Disease Forum This expert forum is not accepting new questions. Please post your question in one of our medical support ... My impression is that it is muscular or nerve in origin, but it is ONLY my impression. (11) Here is where I am confused. ...
About Neuromuscular Diseases | Muscular Dystrophy Association
ALS and related diseases by funding worldwide research. ... MDA is the nonprofit health agency dedicated to curing muscular ... About Neuromuscular Diseases. A look at causes, symptoms, and care options for neuromuscular diseases, and how were leading ... The power in our research approach is that we can often apply learnings from one disease to progress in others to bring ... At MDA, we take a big picture perspective across the full spectrum of neuromuscular diseases to uncover scientific and medical ...
Muscular-skeletal diseases | Health and medicine | Science | Khan Academy
... but arthritis is one of a group of diseases that affect joints, muscles, and bones called musculoskeletal diseases. In this ... section, youll learn about the symptoms, causes and treatments for these diseases. ... but arthritis is one of a group of diseases that affect joints, muscles, and bones called musculoskeletal diseases. In this ... section, youll learn about the symptoms, causes and treatments for these diseases. ...
Journal News: JBC: Cow muscular disease
Exploring muscular disease in humans and cattle. Insights into treatment of Brody disease through inhibition of the ubiquitin- ... Both the Chianina cattle muscular disease pseudomyotonia and the human Brody disease are characterized by an inability of ... Journal of Biological Chemistry about a muscular disease in cattle may offer clues about how to treat a similar disease found ... Because of such phenotypic and genetic overlap, Chianina pseudomyotonia is studied as a model for Brody disease. ...
Disease-specific and glucocorticoid-responsive serum biomarkers for Duchenne Muscular Dystrophy | Scientific Reports
Disease-specific and glucocorticoid-responsive serum biomarkers for Duchenne Muscular Dystrophy. *Yetrib Hathout. 1. , ... Tracking disease progression non-invasively in Duchenne and Becker muscular dystrophies. Journal of Cachexia, Sarcopenia and ... Expression profiling of disease progression in canine model of Duchenne muscular dystrophy. Plos One 13, e0194485 (2018). ... Affinity proteomics within rare diseases: a BIO-NMD study for blood biomarkers of muscular dystrophies. EMBO Molecular Medicine ...
How Effective is Stem Cell Therapy For Muscular Dystrophy - Diseases
Muscular dystrophy is one of the most severely disabling genetic disorders. This group of almost 30 genetic diseases results in ... Home Remedies for Muscular Cramps That Are Safe and Natural. Muscular cramps usually occur in the quadriceps, calf muscles and ... Ayurvedic Muscular Dystrophy Treatment in India. Muscular dystrophy refers to the muscle-wasting disorders which result in ... Stem cell treatment of muscular dystrophy Although there is no definite and proven cure for treating muscular dystrophy, stem ...
facioscapulohumeral muscular dystrophy Disease Ontology Browser - DOID:11727
Synonyms: Landouzy Dejerine muscular dystrophy; Landouzy-Dejerine muscular dystrophy; Landouzy-Dejerine muscular dystrophy; ... Mutations in human and/or mouse homologs are associated with this disease. ... Disease Ontology Browser facioscapulohumeral muscular dystrophy (DOID:11727) Alliance: disease page Synonyms: Landouzy Dejerine ... muscular dystrophy; Landouzy-Dejerine muscular dystrophy; Landouzy-Dejerine muscular dystrophy; Muscular dystrophy, Landouzy- ...
Rare Neurological Diseases: Spinal Muscular Atrophy and Huntington's Disease
MD provide an overview of rare diseases, specifically spinal muscular atrophy (SMA) and Huntington ... Rare Neurological Diseases: Spinal Muscular Atrophy and Huntingtons Disease. Dr Peter Salgo, MD; Dr John Brandsema, MD; Sika ... Dunyoh; Dr Maria Lopes, MD, MS; and Dr Surya Singh, MD provide an overview of rare diseases, specifically spinal muscular ... The panel members review a pipeline medication, risdiplam, and provide some final thoughts on the future of spinal muscular ...
Study describes new muscular disease caused by mutation in myoglobin gene
Montse Olivé have described in Nature Communications a new muscular disease caused by a mutation in the myoglobin gene. ... responsible for the muscular disease area and researcher of the Human Molecular Genetics group of the Genes, Disease and ... Study describes new muscular disease caused by mutation in myoglobin gene. *Download PDF Copy ... Montse Olivé have described in Nature Communications a new muscular disease caused by a mutation in the myoglobin gene. The ...
Conditions and Diseases -- Skeletal and Muscular Systems | St. David's HealthCare
10: Spinal Muscular Atrophy (SMA) - Top 10 Rare Diseases | HowStuffWorks
Human In Vitro Models of Pediatric Muscular Diseases
Here, we review the spatiotemporal scales of muscular diseases of childhood in order to specify the design criteria of in vitro ... Lastly, we present a model Duchenne muscular dystrophy (DMD), the most common childhood-lethal genetic disease. Specifically, ... In particular, many diseases of childhood are rare genetic diseases that limit clinical trial utility due to small patient ... The development of new therapies for pediatric diseases over the past few decades has been hampered by a lack of human-relevant ...
Is Spinal Muscular Atrophy a Disease of Sensory Neurons? | ALZFORUM
Is Spinal Muscular Atrophy a Disease of Sensory Neurons?. Quick Links. *Article ... miRNA malfunction causes spinal motor neuron disease. Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13111-6. PubMed. ... CNS-targeted gene therapy improves survival and motor function in a mouse model of spinal muscular atrophy. J Clin Invest. 2010 ... The work helps answer a longstanding puzzle in spinal muscular atrophy (SMA): How do people and mice get so weak, even though ...
Translational Study Demonstrates Value of MSOT Imaging for the Assessment of Disease Progression in Duchenne Muscular Dystrophy
DMD is the most common lethal inherited muscular disease occurring in about one of 5,000 male births. While ... DMD is the most common lethal inherited muscular disease occurring in about one of 5,000 male births. While affected boys can ... and quantify changes in tissue composition associated with the progression of the rare muscle disease Duchenne Muscular ... It suggests its application as a non-invasive, age-independent biomarker for Duchenne Muscular Dystrophy.. ...
TCTEX1D1 is a genetic modifier of disease progression in Duchenne muscular dystrophy | European Journal of Human Genetics
Variability in the disease course suggests that other factors influence disease progression. With this study we aimed to ... Our data show that disease progression of DMD is affected by a new locus on chromosome 1 and demonstrate the possibility to ... data in 27 DMD patients with extreme phenotypes to identify candidate variants that could affect disease progression. ... Duchenne muscular dystrophy (DMD) is caused by pathogenic variants in the DMD gene leading to the lack of dystrophin. ...
Petition · We need Spinraza in pakistan, A treatment for rare disease Spinal Muscular Atrophy · Change.org
We need Spinraza in pakistan, A treatment for rare disease Spinal Muscular Atrophy. ... Spinal Muscular Atrophy is now curable in the world, SPINRAZA is now available all over the world, THE CURE for SMA . SMA ... sign the petition HELP ME & OTHERS WITH SPINAL MUSCULAR ATROPHY to have SPINRAZA in PAKISTAN & in their country too !. Javaria ...
Petition · Make rare disease treatment SPINRAZA,for SPINAL MUSCULAR ATROPHY available in SOUTH AFRICA · Change.org
Make rare disease treatment SPINRAZA,for SPINAL MUSCULAR ATROPHY available in SOUTH AFRICA. ... Spinal Muscular Atrophy is an autosomal recessive degenerative genetic disorder and is considered the #1 genetic cause of ... an antisense oligonucleotide also known as Spinraza received FDA approval for all types of Spinal Muscular Atrophy. Spinraza, ...
Muscular dystrophy could be the next disease to get whacked by gene therapy - MIT Technology Review
... and its stoking hopes that scientists will cure this disease for good. ... Four boys have received a gene-replacement treatment for muscular dystrophy, ... Muscular dystrophy could be the next disease to get whacked by gene therapy. Four boys have received a gene-replacement ... Muscular dystrophy is common, fatal, and currently incurable. But gene therapy might solve it. Sareptas stock shot up today by ...
Study Shows Promise in Treating Heart Disease Associated With Muscular Dystrophy - NBC Los Angeles
Study Shows Promise in Treating Heart Disease Associated With Muscular Dystrophy Study on mice shows stem cells may help to ... Over time, as with all muscular dystrophy patients, the disease caused scarring in his heart and lungs. ... Stem cells are immature cells that may be used on disease areas to regrow tissue, and theyve already been used to regrow ... Dusty Brandom, 22, who has muscular dystrophy, said he knows his weakened muscles are just part of the problem. ...
Kennedy's Disease (Bulbospinal Muscular Atrophy, X-Linked Spinal and Bulbar Muscular Atrophy)
Kennedys Disease (Bulbospinal Muscular Atrophy, X-Linked Spinal and Bulbar Muscular Atrophy). Kennedys disease is a rare ... There is currently no cure for Kennedys disease.. What causes Kennedys disease?. Kennedys disease is classed as an X-linked ... Kennedys disease diagnosis. Kennedys disease can usually be diagnosed based on symptoms, but genetic testing may be ordered ... Treating Kennedys disease. There is currently no cure for Kennedys disease. However, treatments can help to reduce symptoms ...
Cost Burden of Managing Duchenne Muscular Dystrophy and Disease Progression
... are already far higher than for individuals without the disease, and a new study has found that total healthcare costs are also ... Healthcare costs for patients with Duchenne muscular dystrophy (DMD) ... Cost Burden of Managing Duchenne Muscular Dystrophy and Disease Progression. @media screen and (max-width: 468px) { .video- ... EmployersFabry DiseaseHeart FailureHematologyHIVImmuno-OncologyInfectious DiseaseInflammationLeukemia and LymphomaLiver Disease ...
JCI -
Muscle-specific SMN reduction reveals motor neuron-independent disease in spinal muscular atrophy models
Muscle-specific SMN reduction reveals motor neuron-independent disease in spinal muscular atrophy models. ... Muscle-specific SMN reduction reveals motor neuron-independent disease in spinal muscular atrophy models. ... Although a disease phenotype was not immediately obvious, persistent low levels of the protein eventually resulted in muscle ... We investigated the disease-contributing effects of low SMN in one relevant peripheral organ - skeletal muscle - by selectively ...
autosomal recessive limb-girdle muscular dystrophy type 2M Disease Ontology Browser - DOID:0110296
Synonyms: LGMD2M; MDDGC4; muscular dystrophy-dystroglycanopathy (limb-girdle) type C 4 ... Mutations in human and/or mouse homologs are associated with this disease. ... Disease Ontology Browser autosomal recessive limb-girdle muscular dystrophy type 2M (DOID:0110296) Alliance: disease page ... Synonyms: LGMD2M; MDDGC4; muscular dystrophy-dystroglycanopathy (limb-girdle) type C 4 Alt IDs: OMIM:611588, ICD10CM:G71.0, ...
Types of Muscular Dystrophy and Neuromuscular Diseases - AHealthyMe - Blue Cross Blue Shield of Massachusetts
Muscular dystrophy is a group of inherited diseases that are characterized by weakness and wasting away of muscle tissue, with ... Types of Muscular Dystrophy and Neuromuscular Diseases. What are the different types of muscular dystrophy?. Muscular dystrophy ... The most well known of the muscular dystrophies is Duchenne muscular dystrophy (DMD), followed by Becker muscular dystrophy ( ... What are other neuromuscular diseases?. Spinal muscular atrophies:. * Amyotrophic lateral sclerosis (ALS), or motor neuron ...
Androgen-modulating agents for spinal bulbar muscular atrophy/Kennedy's disease | Cochrane
Androgen-modulating agents for spinal bulbar muscular atrophy/Kennedys disease. To assess the effects of androgen-modulating ... Androgen-modulating agents for spinal bulbar muscular atrophy/Kennedys disease. Cochrane Database of Systematic Reviews 2015, ... Drug treatment for spinal muscular atrophy types II and III. *Physical exercise training for people with spinal muscular ... Botulinum Toxin type A (BtA) muscular injections are beneficial in treating hemifacial spasm. ...