A species of the genus PNEUMOVIRUS causing pneumonia in mice.
Infections with viruses of the genus PNEUMOVIRUS, family PARAMYXOVIRIDAE. This includes RESPIRATORY SYNCYTIAL VIRUS INFECTIONS, an important cause of respiratory disease in humans.
A genus of the family PARAMYXOVIRIDAE (subfamily PNEUMOVIRINAE) where the human and bovine virions have neither hemagglutinin nor neuraminidase activity. RESPIRATORY SYNCYTIAL VIRUS, HUMAN is the type species.
Inflammation of the lung parenchyma that is caused by bacterial infections.
Infection of the lung often accompanied by inflammation.
Inflammation of the lung parenchyma that is caused by a viral infection.
Chronic respiratory disease caused by the VISNA-MAEDI VIRUS. It was formerly believed to be identical with jaagsiekte (PULMONARY ADENOMATOSIS, OVINE) but is now recognized as a separate entity.
A febrile disease caused by STREPTOCOCCUS PNEUMONIAE.
A family of spherical viruses, of the order MONONEGAVIRALES, somewhat larger than the orthomyxoviruses, and containing single-stranded RNA. Subfamilies include PARAMYXOVIRINAE and PNEUMOVIRINAE.
A species of LENTIVIRUS, subgenus ovine-caprine lentiviruses (LENTIVIRUSES, OVINE-CAPRINE), that can cause chronic pneumonia (maedi), mastitis, arthritis, and encephalomyelitis (visna) in sheep. Maedi is a progressive pneumonia of sheep which is similar to but not the same as jaagsiekte (PULMONARY ADENOMATOSIS, OVINE). Visna is a demyelinating leukoencephalomyelitis of sheep which is similar to but not the same as SCRAPIE.
A subgenus of LENTIVIRUS comprising viruses that produce multi-organ disease with long incubation periods in sheep and goats.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
Viruses whose taxonomic relationships have not been established.
A contagious, neoplastic, pulmonary disease of sheep characterized by hyperplasia and hypertrophy of pneumocytes and epithelial cells of the lung. It is caused by JAAGSIEKTE SHEEP RETROVIRUS.
Viruses whose genetic material is RNA.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Substances that reduce the growth or reproduction of BACTERIA.
Virus diseases caused by the Lentivirus genus. They are multi-organ diseases characterized by long incubation periods and persistent infection.
Diseases of domestic and mountain sheep of the genus Ovis.
A group of viruses in the PNEUMOVIRUS genus causing respiratory infections in various mammals. Humans and cattle are most affected but infections in goats and sheep have also been reported.
The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle.
Minute infectious agents whose genomes are composed of DNA or RNA, but not both. They are characterized by a lack of independent metabolism and the inability to replicate outside living host cells.
An interstitial lung disease of unknown etiology, occurring between 21-80 years of age. It is characterized by a dramatic onset of a "pneumonia-like" illness with cough, fever, malaise, fatigue, and weight loss. Pathological features include prominent interstitial inflammation without collagen fibrosis, diffuse fibroblastic foci, and no microscopic honeycomb change. There is excessive proliferation of granulation tissue within small airways and alveolar ducts.
Diseases of rodents of the order RODENTIA. This term includes diseases of Sciuridae (squirrels), Geomyidae (gophers), Heteromyidae (pouched mice), Castoridae (beavers), Cricetidae (rats and mice), Muridae (Old World rats and mice), Erethizontidae (porcupines), and Caviidae (guinea pigs).
Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).
Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.
A pulmonary disease in humans occurring in immunodeficient or malnourished patients or infants, characterized by DYSPNEA, tachypnea, and HYPOXEMIA. Pneumocystis pneumonia is a frequently seen opportunistic infection in AIDS. It is caused by the fungus PNEUMOCYSTIS JIROVECII. The disease is also found in other MAMMALS where it is caused by related species of Pneumocystis.
Substances elaborated by viruses that have antigenic activity.
Pneumonia caused by infections with bacteria of the genus STAPHYLOCOCCUS, usually with STAPHYLOCOCCUS AUREUS.
The type species of ORTHOPOXVIRUS, related to COWPOX VIRUS, but whose true origin is unknown. It has been used as a live vaccine against SMALLPOX. It is also used as a vector for inserting foreign DNA into animals. Rabbitpox virus is a subspecies of VACCINIA VIRUS.
Any of numerous agile, hollow-horned RUMINANTS of the genus Capra, in the family Bovidae, closely related to the SHEEP.

Gene expression in epithelial cells in response to pneumovirus infection. (1/43)

Respiratory syncytial virus (RSV) and pneumonia virus of mice (PVM) are viruses of the family Paramyxoviridae, subfamily pneumovirus, which cause clinically important respiratory infections in humans and rodents, respectively. The respiratory epithelial target cells respond to viral infection with specific alterations in gene expression, including production of chemoattractant cytokines, adhesion molecules, elements that are related to the apoptosis response, and others that remain incompletely understood. Here we review our current understanding of these mucosal responses and discuss several genomic approaches, including differential display reverse transcription-polymerase chain reaction (PCR) and gene array strategies, that will permit us to unravel the nature of these responses in a more complete and systematic manner.  (+info)

Eosinophils, eosinophil ribonucleases, and their role in host defense against respiratory virus pathogens. (2/43)

Eosinophils remain among the most enigmatic of cells, as our appreciation of their detrimental activities--e.g., asthma and allergic disease--far outweighs our understanding of their beneficial effects. Among the major secretory effector proteins of eosinophils are the ribonucleases eosinophil-derived neurotoxin (EDN) and eosinophil cationic protein (ECP) in primates and their orthologs, the eosinophil-associated ribonucleases (EARs) in rodents. The rapid diversification observed among these ribonucleases suggested that the ultimate target(s) might be similarly efficient at generating sequence diversity while maintaining an unalterable susceptibility to ribonucleolytic cleavage. This has prompted us to consider a role for these proteins and by extension, for eosinophils, in host defense against single-stranded RNA virus pathogens. We detail our studies of the antiviral activity of eosinophils and eosinophil ribonucleases against respiratory syncytial virus (RSV) in vitro and the related, natural rodent pathogen, pneumonia virus of mice (PVM), in vivo, and consider the possibility that antiviral host defense and the dysregulated responses leading to asthma represent opposing sides of an eosinophil-mediated double-edged sword.  (+info)

Glucocorticoid administration accelerates mortality of pneumovirus-infected mice. (3/43)

The use of glucocorticoids for the treatment of symptoms associated with respiratory syncytial virus (RSV) infection has been questioned. To evaluate the sequelae of glucocorticoid administration in the setting of pneumovirus infection in vivo, hydrocortisone was administered to mice infected with pneumonia virus of mice (PVM), a pneumovirus and natural rodent pathogen that is closely related to RSV and replicates the signs and symptoms of severe human RSV infection. Results showed that hydrocortisone spared the pulmonary neutrophilia but resulted in ablation of the pulmonary eosinophilia, despite continued production of the relevant chemoattractant, macrophage inflammatory protein-1alpha. Hydrocortisone also led to diminished production of inducible nitric oxide synthase and accumulation of reactive nitrogen species in lung tissue and bronchoalveolar lavage fluid and diminished lymphocyte recruitment. PVM-infected mice responded to hydrocortisone with enhanced viral replication and accelerated mortality. These results suggest several mechanisms to explain why glucocorticoid therapy may be of limited benefit in the overall picture of pneumovirus infection.  (+info)

Differential expression of proinflammatory cytokine genes in vivo in response to pathogenic and nonpathogenic pneumovirus infections. (4/43)

Pneumonia virus of mice (PVM; Paramyxoviridae, subfamily Pneumovirinae) is an important pathogen for the study of physiologically relevant acute inflammatory responses in rodent hosts. In contrast to the severe symptomatology observed in response to infection with PVM strain J3666, infection with strain 15 resulted in few clinical symptoms, limited cellular inflammatory response, and no production of macrophage inflammatory protein-1alpha or monocyte chemoattractant peptide (MCP)-1. Microarray analysis of transcripts from lung tissue indicates that PVM J3666 infection promotes up-regulation of specific proinflammatory genes, most notably interferon (IFN)-1beta, IFN response genes, and chemokines MCP-1, MCP-3, RANTES (regulated on activation, normally T cell-expressed and secreted), and eotaxin. Of these, only RANTES expression increased in response to infection with strain 15, with no increased expression of IFN or IFN response genes, despite ongoing viral replication. These results suggest that pneumovirus replication alone is insufficient to promote antiviral inflammation and that evaluation of the more divergent strain-specific pneumovirus proteins may provide some intriguing leads toward the molecular basis of this differential response.  (+info)

Altered pathogenesis of severe pneumovirus infection in response to combined antiviral and specific immunomodulatory agents. (5/43)

We report here the responses of mice with symptomatic pneumovirus infection to combined antiviral and specific immunomodulatory agents. Mice infected with pneumonia virus of mice, a natural mouse pathogen that replicates the signs and symptoms of severe infection with respiratory syncytial virus (RSV), responded to the antiviral agent ribavirin when it was administered in the setting of endogenous (gene deletion) or exogenous (antibody-mediated) blockade of the MIP-1alpha proinflammatory signaling cascade. Although neither treatment is effective alone, together they offer a dramatic reduction in symptoms and pathology, the most impressive of which is a significant reduction in morbidity and mortality. The findings presented are consistent with the notion of unique and independent contributions of virus replication and ongoing inflammation to the pathogenesis of severe respiratory virus infection, and they provide the impetus for the study of this treatment regimen in RSV-infected humans.  (+info)

Identification of amino acids that are critical to the processivity function of respiratory syncytial virus M2-1 protein. (6/43)

The M2-1 protein of respiratory syncytial virus (RSV) is a transcription processivity factor that is essential for virus replication. The function of RSV M2-1 protein can be examined by using an RSVlacZ minigenome assay in vitro since the expression of the lacZ gene is dependent on M2-1. The M2-1 protein of pneumonia virus of mice (PVM), also a member of the Pneumovirus genus, functions poorly in the RSVlacZ minigenome assay despite conservation of the Cys(3)-His(1) motif at its N terminus and an overall 40% amino acid identity with RSV M2-1. To identify the amino acids responsible for the differences between these two proteins, two chimeric proteins were constructed. The RSV/PVM (RP) M2-1 chimera that contains the N-terminal 30 amino acids from RSV and the remaining C-terminal 148 amino acids from PVM maintained a level of activity at an ca. 36% of RSV M2-1. However, the PVM/RSV (PR) M2-1 chimera with the N-terminal 29 amino acids from PVM and 164 amino acids from RSV had an activity of <5% of RSV M2-1, indicating that the functional determinants are mainly located in the N terminus of M2-1. Mutagenesis of the N terminus of PR M2-1 and RSV M2-1 identified that Leu-16 and Asn-17 of RSV M2-1 are critical to the M2-1 function. In addition, several charged residues in the N terminus of RSV M2-1 also contributed to the functional integrity of M2-1.  (+info)

Chimeric pneumovirus nucleocapsid (N) proteins allow identification of amino acids essential for the function of the respiratory syncytial virus N protein. (7/43)

The nucleocapsid (N) protein of the pneumovirus respiratory syncytial virus (RSV) is a major structural protein which encapsidates the RNA genome and is essential for replication and transcription of the RSV genome. The N protein of the related virus pneumonia virus of mice (PVM) is functionally unable to replace the RSV N protein in a minigenome replication assay. Using chimeric proteins, in which the immediate C-terminal part of the RSV N protein was replaced with the equivalent region of the PVM N protein, it was shown that six amino acid residues near the C terminus of the N protein (between residues 352-369) are essential for its function in replication and for the ability of the N protein to bind to the viral phosphoprotein, P.  (+info)

Reevaluation of the virulence of prototypic strain 15 of pneumonia virus of mice. (8/43)

Prototypic strain 15 of pneumonia virus of mice (PVM) has been described as being nonpathogenic in mice, in contrast to the mouse-passaged, highly virulent strain J3666. Previous sequence analysis also indicated that strain 15 encodes an attachment G protein that is truncated at the amino terminus, which for the amino terminally anchored protein deletes the cytoplasmic tail. However, we found that PVM strain 15 obtained from the American Type Culture Collection was highly virulent in mice and was essentially indistinguishable on that basis from strain J3666. Sequence analysis showed that this preparation of virus encodes a G protein with an intact cytoplasmic tail: the truncated predicted protein in the previous sequence appeared to be due to a single nucleotide insertion that disrupted the upstream end of the open reading frame and shifted the translational start site to the next downstream AUG. Taken together, the two studies indicate that strain 15 is an inherently virulent strain but that a nonpathogenic variant that was generated during passage in vitro and encodes a truncated G protein exists. Interestingly, the majority sequence of strain J3666 was found to encode a G protein with an extended cytoplasmic tail, suggesting that there is the potential for considerable plasticity in the cytoplasmic tail of the G protein of PVM.  (+info)

Murine pneumonia virus (MPV) is not a widely recognized or officially established medical term. However, it may refer to the Pneumonia Virus of Mice (PVM), which is a pathogen that affects mice and can cause interstitial pneumonia.

PVM is an enveloped, single-stranded, negative-sense RNA virus belonging to the family Paramyxoviridae and the genus Pneumovirus. It primarily infects laboratory mice but has also been found in wild mouse populations. The virus replicates in the respiratory epithelium, leading to interstitial pneumonia and inflammation of the airways.

It is essential to note that Murine Pneumonia Virus should not be confused with Hantavirus Pulmonary Syndrome (HPS), which is also known as "mouse-related pulmonary syndrome." HPS is a severe, sometimes fatal, respiratory disease in humans caused by exposure to hantaviruses, which are found in rodents.

Pneumovirus infections refer to respiratory illnesses caused by viruses belonging to the Pneumoviridae family, specifically human respirovirus (hRSV) and human metapneumovirus (hMPV). These viruses primarily infect the respiratory tract and can cause a wide range of symptoms, from mild upper respiratory tract infections to severe lower respiratory tract illnesses such as bronchiolitis and pneumonia.

Human respirovirus (hRSV) is a leading cause of bronchiolitis and pneumonia in infants and young children, while human metapneumovirus (hMPV) tends to infect older children and adults, causing similar respiratory symptoms. Both viruses can also cause more severe disease in immunocompromised individuals, the elderly, and those with underlying medical conditions.

Transmission of these viruses typically occurs through close contact with infected individuals or contaminated surfaces, and they are highly contagious. Preventive measures include good hygiene practices, such as frequent handwashing and avoiding close contact with sick individuals. Currently, there are no vaccines available to prevent pneumovirus infections, but antiviral treatments and supportive care can help manage the symptoms and reduce the risk of complications.

Pneumovirus is a genus of viruses in the family Pneumoviridae, order Mononegavirales. It includes several species that can cause respiratory infections in humans and animals. The most well-known species that infect humans is Human Respiratory Syncytial Virus (HRSV), which is a major cause of bronchiolitis and pneumonia in young children, the elderly, and immunocompromised individuals. Other human pneumoviruses include Human Metapneumovirus (HMPV) and Avian Metapneumovirus subtype C (AMPV-C). These viruses can cause similar respiratory symptoms, ranging from mild to severe.

Pneumoviruses are enveloped, negative-sense, single-stranded RNA viruses that replicate in the cytoplasm of infected cells. They have a nonsegmented genome and encode several structural proteins, including an attachment protein, fusion protein, matrix protein, and nucleocapsid protein. The virions are typically pleomorphic, with a diameter of 150-250 nm.

Transmission of pneumoviruses occurs through respiratory droplets or direct contact with contaminated surfaces. Preventive measures include good hygiene practices, such as hand washing and covering the mouth and nose when coughing or sneezing. There are currently no vaccines available for human pneumoviruses, but several candidates are in development. Treatment is primarily supportive and may include oxygen therapy, mechanical ventilation, and antiviral medications in severe cases.

Bacterial pneumonia is a type of lung infection that's caused by bacteria. It can affect people of any age, but it's more common in older adults, young children, and people with certain health conditions or weakened immune systems. The symptoms of bacterial pneumonia can vary, but they often include cough, chest pain, fever, chills, and difficulty breathing.

The most common type of bacteria that causes pneumonia is Streptococcus pneumoniae (pneumococcus). Other types of bacteria that can cause pneumonia include Haemophilus influenzae, Staphylococcus aureus, and Mycoplasma pneumoniae.

Bacterial pneumonia is usually treated with antibiotics, which are medications that kill bacteria. The specific type of antibiotic used will depend on the type of bacteria causing the infection. It's important to take all of the prescribed medication as directed, even if you start feeling better, to ensure that the infection is completely cleared and to prevent the development of antibiotic resistance.

In severe cases of bacterial pneumonia, hospitalization may be necessary for close monitoring and treatment with intravenous antibiotics and other supportive care.

Pneumonia is an infection or inflammation of the alveoli (tiny air sacs) in one or both lungs. It's often caused by bacteria, viruses, or fungi. Accumulated pus and fluid in these air sacs make it difficult to breathe, which can lead to coughing, chest pain, fever, and difficulty breathing. The severity of symptoms can vary from mild to life-threatening, depending on the underlying cause, the patient's overall health, and age. Pneumonia is typically diagnosed through a combination of physical examination, medical history, and diagnostic tests such as chest X-rays or blood tests. Treatment usually involves antibiotics for bacterial pneumonia, antivirals for viral pneumonia, and supportive care like oxygen therapy, hydration, and rest.

Viral pneumonia is a type of pneumonia caused by viral infection. It primarily affects the upper and lower respiratory tract, leading to inflammation of the alveoli (air sacs) in the lungs. This results in symptoms such as cough, difficulty breathing, fever, fatigue, and chest pain. Common viruses that can cause pneumonia include influenza virus, respiratory syncytial virus (RSV), and adenovirus. Viral pneumonia is often milder than bacterial pneumonia but can still be serious, especially in young children, older adults, and people with weakened immune systems. Treatment typically involves supportive care, such as rest, hydration, and fever reduction, while the body fights off the virus. In some cases, antiviral medications may be used to help manage symptoms and prevent complications.

Progressive interstitial pneumonia of sheep, also known as ovine progressive pneumonic dyspnea (OPPD), is a contagious and fatal disease that affects the respiratory system of sheep. It is caused by the bacterium Mycoplasma ovipneumoniae.

The disease is characterized by inflammation and fibrosis of the interstitial tissue of the lungs, which leads to progressive difficulty in breathing, coughing, and weight loss. The infection can also spread to the air sacs (alveoli) of the lungs, causing pus-filled lesions and further compromising lung function.

OPPD is a chronic disease that can take several months to progress from initial infection to death. It is highly contagious and can be spread through direct contact with infected animals or contaminated equipment. The disease is most commonly seen in sheep that are under stress, such as those that have been transported or housed in close quarters.

Prevention and control measures for OPPD include good biosecurity practices, such as quarantine and testing of new animals before introducing them to a flock, as well as vaccination of susceptible animals. Treatment is generally not effective once clinical signs appear, and affected animals usually need to be euthanized to prevent further spread of the disease.

Pneumonia, pneumococcal is a type of pneumonia caused by the bacterium Streptococcus pneumoniae (also known as pneumococcus). This bacteria can colonize the upper respiratory tract and occasionally invade the lower respiratory tract, causing infection.

Pneumococcal pneumonia can affect people of any age but is most common in young children, older adults, and those with weakened immune systems. The symptoms of pneumococcal pneumonia include fever, chills, cough, chest pain, shortness of breath, and rapid breathing. In severe cases, it can lead to complications such as bacteremia (bacterial infection in the blood), meningitis (inflammation of the membranes surrounding the brain and spinal cord), and respiratory failure.

Pneumococcal pneumonia can be prevented through vaccination with the pneumococcal conjugate vaccine (PCV) or the pneumococcal polysaccharide vaccine (PPSV). These vaccines protect against the most common strains of Streptococcus pneumoniae that cause invasive disease. It is also important to practice good hygiene, such as covering the mouth and nose when coughing or sneezing, and washing hands frequently, to prevent the spread of pneumococcal bacteria.

Paramyxoviridae is a family of negative-sense, single-stranded RNA viruses that include several medically important pathogens. These viruses are characterized by their enveloped particles and helical symmetry. The paramyxoviruses can cause respiratory infections, neurological disorders, and other systemic diseases in humans, animals, and birds.

Some notable members of the Paramyxoviridae family include:

* Human respirovirus (also known as human parainfluenza virus): causes upper and lower respiratory tract infections in children and adults.
* Human orthopneumovirus (also known as respiratory syncytial virus, or RSV): a major cause of bronchiolitis and pneumonia in infants and young children.
* Measles morbillivirus: causes measles, a highly contagious viral disease characterized by fever, rash, and cough.
* Mumps virus: causes mumps, an acute infectious disease that primarily affects the salivary glands.
* Hendra virus and Nipah virus: zoonotic paramyxoviruses that can cause severe respiratory and neurological disease in humans and animals.

Effective vaccines are available for some paramyxoviruses, such as measles and mumps, but there are currently no approved vaccines for others, such as RSV and Nipah virus. Antiviral therapies are also limited, with only a few options available for the treatment of severe paramyxovirus infections.

Visna-maedi virus (VMV) is an retrovirus that belongs to the genus Lentivirus, which is part of the family Retroviridae. This virus is the causative agent of a slowly progressive, fatal disease in sheep known as maedi-visna. The term "visna" refers to a inflammatory disease of the central nervous system (CNS) and "maedi" refers to a progressive interstitial pneumonia.

The Visna-Maedi virus is closely related to the human immunodeficiency virus (HIV), which causes AIDS, as well as to other lentiviruses that affect animals such as caprine arthritis encephalitis virus (CAEV) and equine infectious anemia virus (EIAV).

Visna-maedi virus primarily targets the immune system cells, specifically monocytes/macrophages, leading to a weakened immune response in infected animals. This makes them more susceptible to other infections and diseases. The virus is transmitted through the respiratory route and infection can occur through inhalation of infectious aerosols or by ingestion of contaminated milk or colostrum from infected ewes.

There is no effective treatment or vaccine available for Visna-maedi virus infection, and control measures are focused on identifying and isolating infected animals to prevent the spread of the disease within sheep flocks.

Lentiviruses, ovine-caprine, refer to a subgroup of lentiviruses that primarily infect sheep and goats. These viruses are part of the Retroviridae family and cause slowly progressive diseases characterized by immunodeficiency and neurological disorders. The most well-known members of this group include:

1. Ovine progressive pneumonia virus (OPPV/Maedi Visna virus, MVV): This lentivirus primarily affects sheep, causing chronic interstitial pneumonia and progressive wasting. It can also lead to neurological symptoms such as tremors, ataxia, and paralysis in advanced stages.

2. Caprine arthritis-encephalitis virus (CAEV): This lentivirus primarily infects goats, causing chronic arthritis, pneumonia, and mastitis in adult animals. It can also lead to neurological symptoms such as encephalitis, particularly in young kids.

Both OPPV and CAEV are transmitted horizontally through close contact with infected animals, usually via the respiratory route, and vertically from infected ewes or does to their offspring in utero or through colostrum and milk consumption. These viruses have a worldwide distribution and can cause significant economic losses in sheep and goat farming industries due to decreased productivity, increased mortality, and restrictions on trade and movement of infected animals.

A lung is a pair of spongy, elastic organs in the chest that work together to enable breathing. They are responsible for taking in oxygen and expelling carbon dioxide through the process of respiration. The left lung has two lobes, while the right lung has three lobes. The lungs are protected by the ribcage and are covered by a double-layered membrane called the pleura. The trachea divides into two bronchi, which further divide into smaller bronchioles, leading to millions of tiny air sacs called alveoli, where the exchange of gases occurs.

I'm sorry for any confusion, but "Viruses, Unclassified" is not a recognized medical or scientific category. Generally, viruses are classified based on various characteristics such as genome structure, mode of replication, host range, and symptoms they cause. The International Committee on Taxonomy of Viruses (ICTV) is the organization responsible for the formal classification of viruses.

If you have any specific questions about certain unclassified viral entities or phenomena, I'd be happy to help if I can! Please provide more context so I can give a more accurate and helpful response.

Pulmonary Adenomatosis, Ovine, also known as Jaagsiekte or ovine pulmonary carcinoma, is a contagious and fatal disease that affects the lungs of sheep. It is caused by a retrovirus called jaagsiekte sheep retrovirus (JSRV). The virus infects the cells in the lung tissue leading to the formation of tumors known as adenomatosis.

The disease is characterized by progressive respiratory distress, weight loss, and eventual death. It is transmitted through the respiratory route, and infected animals can shed the virus in their saliva, nasal secretions, and feces. The disease has a long incubation period, which can range from several months to years, making it difficult to control.

There is no effective treatment for pulmonary adenomatosis, ovine, and infected animals are usually euthanized to prevent the spread of the virus. Prevention measures include quarantine and testing of new sheep before introducing them into a flock, as well as reducing stress and maintaining good nutrition and overall health in the flock.

RNA viruses are a type of virus that contain ribonucleic acid (RNA) as their genetic material, as opposed to deoxyribonucleic acid (DNA). RNA viruses replicate by using an enzyme called RNA-dependent RNA polymerase to transcribe and replicate their RNA genome.

There are several different groups of RNA viruses, including:

1. Negative-sense single-stranded RNA viruses: These viruses have a genome that is complementary to the mRNA and must undergo transcription to produce mRNA before translation can occur. Examples include influenza virus, measles virus, and rabies virus.
2. Positive-sense single-stranded RNA viruses: These viruses have a genome that can serve as mRNA and can be directly translated into protein after entry into the host cell. Examples include poliovirus, rhinoviruses, and coronaviruses.
3. Double-stranded RNA viruses: These viruses have a genome consisting of double-stranded RNA and use a complex replication strategy involving both transcription and reverse transcription. Examples include rotaviruses and reoviruses.

RNA viruses are known to cause a wide range of human diseases, ranging from the common cold to more severe illnesses such as hepatitis C, polio, and COVID-19. Due to their high mutation rates and ability to adapt quickly to new environments, RNA viruses can be difficult to control and treat with antiviral drugs or vaccines.

Animal disease models are specialized animals, typically rodents such as mice or rats, that have been genetically engineered or exposed to certain conditions to develop symptoms and physiological changes similar to those seen in human diseases. These models are used in medical research to study the pathophysiology of diseases, identify potential therapeutic targets, test drug efficacy and safety, and understand disease mechanisms.

The genetic modifications can include knockout or knock-in mutations, transgenic expression of specific genes, or RNA interference techniques. The animals may also be exposed to environmental factors such as chemicals, radiation, or infectious agents to induce the disease state.

Examples of animal disease models include:

1. Mouse models of cancer: Genetically engineered mice that develop various types of tumors, allowing researchers to study cancer initiation, progression, and metastasis.
2. Alzheimer's disease models: Transgenic mice expressing mutant human genes associated with Alzheimer's disease, which exhibit amyloid plaque formation and cognitive decline.
3. Diabetes models: Obese and diabetic mouse strains like the NOD (non-obese diabetic) or db/db mice, used to study the development of type 1 and type 2 diabetes, respectively.
4. Cardiovascular disease models: Atherosclerosis-prone mice, such as ApoE-deficient or LDLR-deficient mice, that develop plaque buildup in their arteries when fed a high-fat diet.
5. Inflammatory bowel disease models: Mice with genetic mutations affecting intestinal barrier function and immune response, such as IL-10 knockout or SAMP1/YitFc mice, which develop colitis.

Animal disease models are essential tools in preclinical research, but it is important to recognize their limitations. Differences between species can affect the translatability of results from animal studies to human patients. Therefore, researchers must carefully consider the choice of model and interpret findings cautiously when applying them to human diseases.

Anti-bacterial agents, also known as antibiotics, are a type of medication used to treat infections caused by bacteria. These agents work by either killing the bacteria or inhibiting their growth and reproduction. There are several different classes of anti-bacterial agents, including penicillins, cephalosporins, fluoroquinolones, macrolides, and tetracyclines, among others. Each class of antibiotic has a specific mechanism of action and is used to treat certain types of bacterial infections. It's important to note that anti-bacterial agents are not effective against viral infections, such as the common cold or flu. Misuse and overuse of antibiotics can lead to antibiotic resistance, which is a significant global health concern.

Lentivirus infections refer to the infectious disease caused by lentiviruses, a genus of retroviruses. These viruses are characterized by their ability to cause persistent and long-term infections, often leading to chronic diseases. They primarily target cells of the immune system, such as T-cells and macrophages, and can cause significant immunosuppression.

Lentiviruses have a slow replication cycle and can remain dormant in the host for extended periods. This makes them particularly effective at evading the host's immune response and can result in progressive damage to infected tissues over time.

One of the most well-known lentiviruses is the human immunodeficiency virus (HIV), which causes acquired immunodeficiency syndrome (AIDS). HIV infects and destroys CD4+ T-cells, leading to a weakened immune system and increased susceptibility to opportunistic infections.

Other examples of lentiviruses include simian immunodeficiency virus (SIV), feline immunodeficiency virus (FIV), and equine infectious anemia virus (EIAV). While these viruses primarily infect non-human animals, they are closely related to HIV and serve as important models for studying lentivirus infections and developing potential therapies.

I'm happy to help, but I want to clarify that the term "sheep diseases" refers to a wide range of health issues that can affect sheep populations. It's not a single medical condition with a specific definition. Here are some examples of common diseases that can affect sheep:

1. Ovine Johne's Disease (OJD): A chronic, infectious disease caused by the bacterium Mycobacterium avium subspecies paratuberculosis. It affects the intestines and can cause weight loss, diarrhea, and death.
2. Footrot: A highly contagious bacterial infection that affects the feet of sheep, causing lameness, swelling, and pain. It's caused by the bacteria Dichelobacter nodosus.
3. Caseous Lymphadenitis (CL): A chronic infectious disease caused by the bacterium Corynebacterium pseudotuberculosis. It affects the lymph nodes and can cause abscesses, weight loss, and death.
4. Contagious Ecthyma (Orf): A highly contagious viral infection that affects the skin and mucous membranes of sheep, causing sores and lesions.
5. Mastitis: An inflammation of the mammary gland in sheep, usually caused by a bacterial infection. It can cause decreased milk production, fever, and loss of appetite.
6. Pneumonia: A respiratory infection that can affect sheep, causing coughing, difficulty breathing, and fever. It can be caused by various bacteria or viruses.
7. Enterotoxemia: A potentially fatal disease caused by the overproduction of toxins in the intestines of sheep, usually due to a bacterial infection with Clostridium perfringens.
8. Polioencephalomalacia (PEM): A neurological disorder that affects the brain of sheep, causing symptoms such as blindness, circling, and seizures. It's often caused by a thiamine deficiency or excessive sulfur intake.
9. Toxoplasmosis: A parasitic infection that can affect sheep, causing abortion, stillbirth, and neurological symptoms.
10. Blue tongue: A viral disease that affects sheep, causing fever, respiratory distress, and mouth ulcers. It's transmitted by insect vectors and is often associated with climate change.

Respiratory Syncytial Viruses (RSV) are a common type of virus that cause respiratory infections, particularly in young children and older adults. They are responsible for inflammation and narrowing of the small airways in the lungs, leading to breathing difficulties and other symptoms associated with bronchiolitis and pneumonia.

The term "syncytial" refers to the ability of these viruses to cause infected cells to merge and form large multinucleated cells called syncytia, which is a characteristic feature of RSV infections. The virus spreads through respiratory droplets when an infected person coughs or sneezes, and it can also survive on surfaces for several hours, making transmission easy.

RSV infections are most common during the winter months and can cause mild to severe symptoms depending on factors such as age, overall health, and underlying medical conditions. While RSV is typically associated with respiratory illnesses in children, it can also cause significant disease in older adults and immunocompromised individuals. Currently, there is no vaccine available for RSV, but antiviral medications and supportive care are used to manage severe infections.

Virus replication is the process by which a virus produces copies or reproduces itself inside a host cell. This involves several steps:

1. Attachment: The virus attaches to a specific receptor on the surface of the host cell.
2. Penetration: The viral genetic material enters the host cell, either by invagination of the cell membrane or endocytosis.
3. Uncoating: The viral genetic material is released from its protective coat (capsid) inside the host cell.
4. Replication: The viral genetic material uses the host cell's machinery to produce new viral components, such as proteins and nucleic acids.
5. Assembly: The newly synthesized viral components are assembled into new virus particles.
6. Release: The newly formed viruses are released from the host cell, often through lysis (breaking) of the cell membrane or by budding off the cell membrane.

The specific mechanisms and details of virus replication can vary depending on the type of virus. Some viruses, such as DNA viruses, use the host cell's DNA polymerase to replicate their genetic material, while others, such as RNA viruses, use their own RNA-dependent RNA polymerase or reverse transcriptase enzymes. Understanding the process of virus replication is important for developing antiviral therapies and vaccines.

A virus is a small infectious agent that replicates inside the living cells of an organism. It is not considered to be a living organism itself, as it lacks the necessary components to independently maintain its own metabolic functions. Viruses are typically composed of genetic material, either DNA or RNA, surrounded by a protein coat called a capsid. Some viruses also have an outer lipid membrane known as an envelope.

Viruses can infect all types of organisms, from animals and plants to bacteria and archaea. They cause various diseases by invading the host cell, hijacking its machinery, and using it to produce numerous copies of themselves, which can then infect other cells. The resulting infection and the immune response it triggers can lead to a range of symptoms, depending on the virus and the host organism.

Viruses are transmitted through various means, such as respiratory droplets, bodily fluids, contaminated food or water, and vectors like insects. Prevention methods include vaccination, practicing good hygiene, using personal protective equipment, and implementing public health measures to control their spread.

Cryptogenic organizing pneumonia (COP) is a type of lung disorder that is characterized by the presence of inflammation and scarring in the lungs. The term "cryptogenic" means that the cause of the condition is unknown or unclear.

Organizing pneumonia is a specific pattern of injury to the lungs that can be caused by various factors, including infections, medications, and autoimmune disorders. However, in cases of COP, there is no clear underlying cause that can be identified.

The main symptoms of COP include cough, shortness of breath, fever, and fatigue. The condition can also cause crackles or wheezing sounds when listening to the lungs with a stethoscope. Diagnosis of COP typically involves a combination of imaging studies, such as chest X-rays or CT scans, and lung biopsy.

Treatment for COP usually involves the use of corticosteroids, which can help to reduce inflammation and improve symptoms. In some cases, other medications may also be used to manage the condition. The prognosis for people with COP is generally good, with most individuals responding well to treatment and experiencing improvement in their symptoms over time. However, recurrence of the condition is possible, and long-term monitoring may be necessary.

Rodent-borne diseases are infectious diseases transmitted to humans (and other animals) by rodents, their parasites or by contact with rodent urine, feces, or saliva. These diseases can be caused by viruses, bacteria, fungi, or parasites. Some examples of rodent-borne diseases include Hantavirus Pulmonary Syndrome, Leptospirosis, Salmonellosis, Rat-bite fever, and Plague. It's important to note that rodents can also cause allergic reactions in some people through their dander, urine, or saliva. Proper sanitation, rodent control measures, and protective equipment when handling rodents can help prevent the spread of these diseases.

Microbial sensitivity tests, also known as antibiotic susceptibility tests (ASTs) or bacterial susceptibility tests, are laboratory procedures used to determine the effectiveness of various antimicrobial agents against specific microorganisms isolated from a patient's infection. These tests help healthcare providers identify which antibiotics will be most effective in treating an infection and which ones should be avoided due to resistance. The results of these tests can guide appropriate antibiotic therapy, minimize the potential for antibiotic resistance, improve clinical outcomes, and reduce unnecessary side effects or toxicity from ineffective antimicrobials.

There are several methods for performing microbial sensitivity tests, including:

1. Disk diffusion method (Kirby-Bauer test): A standardized paper disk containing a predetermined amount of an antibiotic is placed on an agar plate that has been inoculated with the isolated microorganism. After incubation, the zone of inhibition around the disk is measured to determine the susceptibility or resistance of the organism to that particular antibiotic.
2. Broth dilution method: A series of tubes or wells containing decreasing concentrations of an antimicrobial agent are inoculated with a standardized microbial suspension. After incubation, the minimum inhibitory concentration (MIC) is determined by observing the lowest concentration of the antibiotic that prevents visible growth of the organism.
3. Automated systems: These use sophisticated technology to perform both disk diffusion and broth dilution methods automatically, providing rapid and accurate results for a wide range of microorganisms and antimicrobial agents.

The interpretation of microbial sensitivity test results should be done cautiously, considering factors such as the site of infection, pharmacokinetics and pharmacodynamics of the antibiotic, potential toxicity, and local resistance patterns. Regular monitoring of susceptibility patterns and ongoing antimicrobial stewardship programs are essential to ensure optimal use of these tests and to minimize the development of antibiotic resistance.

I apologize, but "sheep" is not a term that has a medical definition. It is a common animal with the scientific name Ovis aries. If you have any medical or health-related questions, I would be happy to try and help answer those for you.

"Pneumonia, Pneumocystis" is more commonly referred to as "Pneumocystis pneumonia (PCP)." It is a type of pneumonia caused by the microorganism Pneumocystis jirovecii. This organism was previously classified as a protozoan but is now considered a fungus.

PCP is an opportunistic infection, which means that it mainly affects people with weakened immune systems, such as those with HIV/AIDS, cancer, transplant recipients, or people taking immunosuppressive medications. The symptoms of PCP can include cough, shortness of breath, fever, and difficulty exercising. It is a serious infection that requires prompt medical treatment, typically with antibiotics.

It's important to note that PCP is not the same as pneumococcal pneumonia, which is caused by the bacterium Streptococcus pneumoniae. While both conditions are types of pneumonia, they are caused by different organisms and require different treatments.

An antigen is any substance that can stimulate an immune response, particularly the production of antibodies. Viral antigens are antigens that are found on or produced by viruses. They can be proteins, glycoproteins, or carbohydrates present on the surface or inside the viral particle.

Viral antigens play a crucial role in the immune system's recognition and response to viral infections. When a virus infects a host cell, it may display its antigens on the surface of the infected cell. This allows the immune system to recognize and target the infected cells for destruction, thereby limiting the spread of the virus.

Viral antigens are also important targets for vaccines. Vaccines typically work by introducing a harmless form of a viral antigen to the body, which then stimulates the production of antibodies and memory T-cells that can recognize and respond quickly and effectively to future infections with the actual virus.

It's worth noting that different types of viruses have different antigens, and these antigens can vary between strains of the same virus. This is why there are often different vaccines available for different viral diseases, and why flu vaccines need to be updated every year to account for changes in the circulating influenza virus strains.

Staphylococcal pneumonia is a type of pneumonia caused by the bacterium Staphylococcus aureus. This bacteria can colonize the upper respiratory tract and sometimes invade the lower respiratory tract, causing pneumonia.

The symptoms of staphylococcal pneumonia are often severe and may include fever, cough, chest pain, shortness of breath, and production of purulent sputum. The disease can progress rapidly, leading to complications such as pleural effusion (accumulation of fluid in the space surrounding the lungs), empyema (pus in the pleural space), and bacteremia (bacteria in the bloodstream).

Staphylococcal pneumonia can occur in otherwise healthy individuals, but it is more common in people with underlying medical conditions such as chronic lung disease, diabetes, or a weakened immune system. It can also occur in healthcare settings, where S. aureus may be transmitted from person to person or through contaminated equipment.

Treatment of staphylococcal pneumonia typically involves the use of antibiotics that are active against S. aureus, such as nafcillin or vancomycin. In some cases, surgery may be necessary to drain fluid from the pleural space.

Vaccinia virus is a large, complex DNA virus that belongs to the Poxviridae family. It is the virus used in the production of the smallpox vaccine. The vaccinia virus is not identical to the variola virus, which causes smallpox, but it is closely related and provides cross-protection against smallpox infection.

The vaccinia virus has a unique replication cycle that occurs entirely in the cytoplasm of infected cells, rather than in the nucleus like many other DNA viruses. This allows the virus to evade host cell defenses and efficiently produce new virions. The virus causes the formation of pocks or lesions on the skin, which contain large numbers of virus particles that can be transmitted to others through close contact.

Vaccinia virus has also been used as a vector for the delivery of genes encoding therapeutic proteins, vaccines against other infectious diseases, and cancer therapies. However, the use of vaccinia virus as a vector is limited by its potential to cause adverse reactions in some individuals, particularly those with weakened immune systems or certain skin conditions.

I'm sorry for any confusion, but "goats" is not a term commonly used in medical definitions. It is a common noun referring to the domesticated animal species Capra aegagrus hircus. If you have any questions about a specific medical condition or term, please provide that and I would be happy to help.

... human respiratory syncytial virus •Bos primigenius: bovine respiratory syncytial virus •Rodentia: murine pneumonia virus Mild ... Human respiratory syncytial virus (HRSV) is the most known orthopneumovirus because of its direct correlation and importance in ... The Viruses. pp. 103-62. doi:10.1007/978-1-4615-3790-8_4. ISBN 978-1-4613-6689-8. (Articles with short description, Short ... Other viruses in this taxon include canine pneumovirus. The genus Orthopneumovirus is included in the family Pneumoviridae. ...
If this occurs, the infection can develop into pneumonia. Several diseases, like Rat Coronavirus Infection (RCI), Sendai virus ... and Murine Respiratory Mycoplasmosis (MRM, Mycoplasma pulmonis), are prevalent simply because their highly contagious natures ... In 2017, the Centers for Disease Control reported an outbreak of Seoul virus spread by pet rats. In fiction, pet brown rats are ... "Multi-state Outbreak of Seoul Virus". www.cdc.gov. Retrieved 2017-05-27. Ebert, Roger (2008). Roger Ebert's Four-Star Reviews ...
Brownstein DG, Winkler S (April 1986). "Genetic resistance to lethal Sendai virus pneumonia: virus replication and interferon ... Murine respirovirus, formerly Sendai virus (SeV) and previously also known as murine parainfluenza virus type 1 or ... May 2002). "Sendai virus, a murine parainfluenza virus type 1, replicates to a level similar to human PIV1 in the upper and ... Sendai virus was also used as a backbone for vaccine against respiratory syncytial virus (HRSV). This virus (HRSV), is a major ...
... pneumonia of calves, enzootic MeSH C22.196.106 - bovine virus diarrhea-mucosal disease MeSH C22.196.148 - brucellosis, bovine ... murine acquired immunodeficiency syndrome MeSH C22.836.120 - bluetongue MeSH C22.836.160 - border disease MeSH C22.836.259 - ... pneumonia of swine, mycoplasmal MeSH C22.905.700 - porcine reproductive and respiratory syndrome MeSH C22.905.832 - swine ... marburg virus disease MeSH C22.735.500.850 - simian acquired immunodeficiency syndrome MeSH C22.735.750 - monkeypox MeSH ...
The causative virus was identified as mouse hepatitis virus (MHV), later renamed Murine coronavirus. In 1961, a virus was ... The virus primary cause fatal hepatitis and encephalitis. Pneumonia-causing rat coronavirus (RCV) discovered in 1970, and ... Directed by Andrewes, the research laboratory discovered several viruses such as influenza viruses, parainfluenza viruses and ... "hepatoencephalitis group of murine viruses" were grouped into a single species named Mouse hepatitis virus, as approved in 1971 ...
Nigg, C. (Jan 1942). "An Unidentified Virus Which Produces Pneumonia and Systemic Infection in Mice". Science. 95 (2454): 49-50 ... "Vaccination against Chlamydia Genital Infection Utilizing the Murine C. muridarum Model". Infection and Immunity. 79 (3): 986- ... "Vaccination against Chlamydia Genital Infection Utilizing the Murine C. muridarum Model". Infection and Immunity. 79 (3): 986- ...
Mouse hepatitis virus (MHV), which is a member of the species Murine coronavirus, causes an epidemic murine illness with high ... Coronaviruses can cause pneumonia (either direct viral pneumonia or secondary bacterial pneumonia) and bronchitis (either ... The virus was then known as infectious bronchitis virus (IBV). Charles D. Hudson and Fred Robert Beaudette cultivated the virus ... Sialodacryoadenitis virus (SDAV), which is a strain of the species Murine coronavirus, is highly infectious coronavirus of ...
While it has been commonly known that the influenza virus increases one's chances of contracting pneumonia or meningitis caused ... "The role of pneumolysin in mediating lung damage in a lethal pneumococcal pneumonia murine model". Respiratory Research. 8 (1 ... Pneumococcal pneumonia is a type of bacterial pneumonia that is caused by Streptococcus pneumoniae (pneumococcus). It is the ... "Pneumonia Causes - Mayo Clinic". www.mayoclinic.org. Retrieved 2016-04-26. "Flu Infection Needed to Allow Spread of Pneumonia ...
Species Murine hepatitis virus; Puffinosis coronavirus; Rat coronavirus (these are to be united in a new species Murine ... and pneumonia, among others. There is little to no obvious difference, and it has been suggested that Parker's rat coronavirus ... MHV-3 is the main virus strain used to study hepatitis; MHV-1 mainly infects the lungs. Murine hepatitis virus is highly ... Murine coronavirus (M-CoV) is a virus in the genus Betacoronavirus that infects mice. Belonging to the subgenus Embecovirus, ...
Despite murine coronavirus being a useful model of coronaviruses, it is still unclear how mouse hepatitis virus is spread. ... "How Coronaviruses Cause Infection-from Colds to Deadly Pneumonia". Scientific American. Retrieved 2020-03-31. "Q & A on COVID- ... She makes use of the murine coronavirus (known as mouse hepatitis virus or MHV) to develop mouse models that allow the study of ... Whereas in the case of SARS, patients were too unwell to leave their homes, so they tended to self-isolate, and the virus was ...
... murine pneumonia virus MeSH B04.820.455.600.670.600.750 - respiratory syncytial viruses MeSH B04.820.455.600.670.600.750.700 - ... harvey murine sarcoma virus MeSH B04.265.600.500 - kirsten murine sarcoma virus MeSH B04.265.600.600 - moloney murine sarcoma ... leukemia virus, murine MeSH B04.820.650.375.525.020 - abelson murine leukemia virus MeSH B04.820.650.375.525.050 - akr murine ... murine MeSH B04.820.650.375.860.400 - harvey murine sarcoma virus MeSH B04.820.650.375.860.500 - kirsten murine sarcoma virus ...
Hwang CK, Svarovskaia ES, Pathak VK (October 2001). "Dynamic copy choice: steady state between murine leukemia virus polymerase ... Centers for Disease Control (CDC) (July 1981). "Kaposi's sarcoma and Pneumocystis pneumonia among homosexual men--New York City ... "In the search for the causative agent, it was initially believed that the virus was a form of the Human T-cell leukemia virus ( ... It is believed to play an important role in cell apoptosis and increase virus infectivity. vpu (Virus protein U) - Vpu is ...
... marburg virus disease MeSH C02.782.417.762 - rift valley fever MeSH C02.782.450.100 - hepatitis d, chronic MeSH C02.782.580.124 ... pneumonia, progressive interstitial, of sheep MeSH C02.782.815.616.850 - simian acquired immunodeficiency syndrome MeSH C02.782 ... 900 - visna MeSH C02.782.815.622 - leukemia, feline MeSH C02.782.815.650 - murine acquired immunodeficiency syndrome MeSH ... bovine virus diarrhea-mucosal disease MeSH C02.782.350.675.200 - classical swine fever MeSH C02.782.350.675.400 - hemorrhagic ...
The correlation between humans and viruses can be understood if it is seen as a "fight" that continues for millennia and that ... It has been determined that Y. pestis became so dangerous because of the acquisition of ymt (yersina murine toxin). This gene ... Bacteria can also disseminate into the bloodstream (causing septicaemia) and to the lung (causing pneumonia). The pulmonary ... Being perfectly aware of the fact that bacteria and viruses are one of the most variable elements in nature, prone to unlimited ...
Plasma Gelsolin Improves Survival in a Murine Model of Penicillin-Susceptible and Penicillin-Resistant Pneumococcal Pneumonia ... Several antiviral agents are host-directed therapeutics, and simply slow the virus progression rather than kill the virus. Host ... Yang Z, Chiou TT, Stossel TP, Kobzik L (July 2015). "Plasma gelsolin improves lung host defense against pneumonia by enhancing ...
... virus infection causing other specified 044 Other human immunodeficiency virus infection 045 Acute poliomyelitis 046 Slow virus ... typhus 081 Other typhus 081.0 Murine typhus (endemic typhus) 081.1 Brill's disease 081.2 Scrub typhus 081.9 Typhus unspecified ... 011.3 Tuberculosis of bronchus 011.4 Tuberculous fibrosis of lung 011.5 Tuberculous bronchiectasis 011.6 Tuberculous pneumonia ... 066 Other arthropod-borne viral diseases 066.4 West Nile virus, unspec. 070 Viral hepatitis 070.0 Hepatitis A with hepatic coma ...
Cheever, F. Sargent; Daniels, Joan B.; Pappenheimer, Alwin M.; Bailey, Orville T. (31 August 1949). "A murine virus (JHM) ... March 2020). "A pneumonia outbreak associated with a new coronavirus of probable bat origin". Nature. 579 (7798): 270-273. ... Coronavirus diseases are caused by viruses in the coronavirus subfamily, a group of related RNA viruses that cause diseases in ... is shared by mouse hepatitis virus and several viruses recently recovered from man, namely strain B814, 229E and several others ...
The team of researchers and clinicians initially collaborated to de-link xenotropic murine leukemia virus-related virus (XMRV) ... was first reported in Saudi Arabia during June 2012 when a local man was initially diagnosed with acute pneumonia and later ... "Ian Lipkin The Virus Hunter" (PDF). Discover. April 2012. Zimmer, Carl (November 22, 2010). "A Man From Whom Viruses Can't Hide ... Lipkin has earned the reputation of a "master virus hunter" due to his speed and innovative methods of identifying new viruses ...
... memory Th17 cells seem to express high levels of CCR4 in both human and murine models of MS and are therefore likely candidates ... "Molecular cloning of a novel T cell-directed CC chemokine expressed in thymus by signal sequence trap using Epstein-Barr virus ... Acute and chronic eosinophilic pneumonia Mycosis fungoides (MF) Sezary syndrome (SS) Lymphocytic variant HES Acute disseminated ... "Molecular cloning of a novel T cell-directed CC chemokine expressed in thymus by signal sequence trap using Epstein-Barr virus ...
Researchers turned to murine typhus to develop a live vaccine. At the time, murine vaccine was viewed as a less severe ... In 1546, Girolamo Fracastoro, a Florentine physician, described typhus in his famous treatise on viruses and contagion, De ... Myocarditis Endocarditis Mycotic aneurysm Pneumonia Pancreatitis Kidney or bladder infections Acute renal failure Meningitis ... Four versions of a live vaccine cultivated from murine typhus were tested, on a large scale, in 1934. While the French were ...
1,270 deaths are where the virus was determined to be the main cause, 435 deaths where the virus had a "significant influence ... Leningrad Oblast banned movement of people between districts and introduced a lockdown in the town of Murino. On 31 March, the ... died of pneumonia (suspected infection) 1 June - Isidore (Kirichenko) [ru], 79, Metropolitan of Ekaterinodar and Kuban' 9 June ... "Putin Eases Nationwide Virus Lockdown as Russia Becomes 3rd Most-Infected Country". The Moscow Times. 11 May 2020. "Russia to ...
Infected cats usually shed the virus for two weeks. Following this period, infected cats never shed the virus again or become ... Pneumonia may develop with secondary bacterial infections. In addition to stomatitis, some cats may develop a polyarthritis, ... "Comparison of the antiviral activity of flavonoids against murine norovirus and feline calicivirus". Food Control. 60: 25-30. ... It is also used in general Caliciviridae research due to its being one of the few of that group of viruses that grows well in ...
Murine PCLS have also demonstrated that Influenza A infection and cigarette smoke can impair bronchodilator responsiveness to ... Kirchhoff, J.; Uhlenbruck, S.; Goris, K.; Keil, G. M.; Herrler, G. (2014). "Three viruses of the bovine respiratory disease ... Craig, A.; Mai, J.; Cai, S.; Jeyaseelan, S. (2009). "Neutrophil recruitment to the lungs during bacterial pneumonia". Infection ... For instance, bovine parainfluenza virus infection was observed primarily in cells beneath the lung epithelium within the PCLS ...
The virus was found on crew members of ships and trains, and all the infected employees spread the virus everywhere they ... Some of the symptoms that COVID-19 patients could experience is shortness of breath (which might be a sign of pneumonia), cough ... Parola P, Vogelaers D, Roure C, Janbon F, Raoult D (1998). "Murine typhus in travelers returning from Indonesia". Emerging ... Since vaccines are made partly from the virus itself, when an unknown virus is introduced into the environment, it takes time ...
The virus appears to have originated in bats. The virus itself has been isolated from a bat. This virus is closely related to ... "Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia". The New England Journal of Medicine. 367 (19): ... Murine coronavirus, Pipistrellus bat coronavirus HKU5, Rousettus bat coronavirus HKU9, Severe acute respiratory syndrome- ... Viruses › ssRNA viruses › Group: IV; positive-sense, single-stranded RNA viruses › Order: Nidovirales › Family: Coronaviridae ...
Louis encephalitis virus West Nile virus Spondweni virus group Spondweni virus Zika virus Yellow fever virus group Yellow fever ... Wasserman, H. A.; Singh, S.; Champagne, D. E. (2004). "Saliva of the Yellow Fever mosquito, Aedes aegypti, modulates murine ... loss of the automatic breathing activity of the brain and other treatable complications like bacterial pneumonia. The WHO ... virus Tick-borne viruses Mammalian tick-borne virus group Kyasanur forest disease virus Tick-borne encephalitis virus Family ...
Nagayo, M.; Tamiya, T.; Mitamura, T.; Sato, K. (1930). "Sur le virus de la maladie de Tsutsugamushi [On the virus of ... murine typhus, chikungunya, and dengue fever. This makes precise clinical diagnosis difficult, which often leads to ... pneumonia, septic shock, subacute thyroiditis, and multiple organ dysfunction syndrome. Harmful effects involving multiple ... But then, the actual infectious agent was not known, and it was generally attributed to either a virus or a protozoan. The ...
"Putin's Virus Response Earns Lower Marks Than Local Leaders': Poll". The Moscow Times. 30 April 2020. Retrieved 2 May 2020. " ... Leningrad Oblast banned movement of people between districts and introduced a lockdown in the town of Murino. On 31 March, the ... of those tested have no symptoms with the number having pneumonia reducing from 25% to 20% and only 5% of patients with a ... As of 23 March, Russia had 4 testing systems and had carried out over 165 thousand tests for the virus which is among the ...
"High prevalence of antibodies to lymphocytic choriomeningitis virus in a murine typhus endemic region in Croatia". J. Med. ... Aspiration pneumonia can be a fatal complication. Infants who survive may have severe neurological defects including epilepsy, ... However, other strains of this virus (Junin and Machupo viruses) are present in parts of South America and other strains ... Understanding the biology of the LCMV model virus will help in advancing the understanding of this important class of viruses ...
Visna/maedi virus ICTVdB - The Universal Virus Database, version 4 Ovine Progressive Pneumonia in Sheep, University of ... Linehan SA, Martinez-Pomares L, Stahl PD, Gordon S (1999). "Mannose receptor and its putative ligands in normal murine lymphoid ... Visna-maedi virus (also known as Visna virus, Maedi-visna virus and Ovine lentivirus) from the genus Lentivirus and subfamily ... Maedi Visna virus is also referred to as ovine progressive pneumonia (OPP). This disease corresponds to two clinical entities ...
Nasal priming by a murine coronavirus provides protective immunity against lethal heterologous virus pneumonia. ... Nasal priming by a murine coronavirus provides protective immunity against lethal heterologous virus pneumonia. ... Here, we showed that nasal inoculation of murine coronavirus (CoV) in the absence of direct lung infection primes the lung ... Clinically, such nasal-only inoculation of MHV-1 failed to cause pneumonia but significantly reduced mortality and morbidity of ...
J-virus; MenV, Menangle virus; MoV, Mossmann virus; MPRV, Mapuera virus; MPV, murine pneumonia virus; NarV, Nariva virus; NiV, ... Nipah virus; PPRV, peste-des-petits-ruminants virus; RPV, Rinderpest virus; SV, Sendai virus; TioV, Tioman virus; TPMV, Tupaia ... canine distemper virus; FDLV, fer-de-lance virus; HeV, Hendra virus; hPIV, human parainfluenza virus; HRSV, human respiratory ... APMV, avian paramyxovirus; AMPV, avian metapneumovirus; bPIV, bovine parainfluenza virus; CDV, ...
... is a natural mouse pathogen that serves as a model for severe human respiratory syncytial virus disease. We have developed a ... Murine pneumonia virus / immunology* * Probiotics / administration & dosage* * Respiratory System / immunology* Substances * ... Pneumonia virus of mice (PVM) is a natural mouse pathogen that serves as a model for severe human respiratory syncytial virus ... Pneumonia virus of mice (PVM) is a natural rodent pathogen that replicates in bronchial epithelial cells and reproduces many ...
If this occurs, the infection can develop into pneumonia. Several diseases, like Rat Coronavirus Infection (RCI), Sendai virus ... and Murine Respiratory Mycoplasmosis (MRM, Mycoplasma pulmonis), are prevalent simply because their highly contagious natures ... In 2017, the Centers for Disease Control reported an outbreak of Seoul virus spread by pet rats. In fiction, pet brown rats are ... "Multi-state Outbreak of Seoul Virus". www.cdc.gov. Retrieved 2017-05-27. Ebert, Roger (2008). Roger Eberts Four-Star Reviews ...
... that enables efficient and specific expression of transgenes by coupling adeno-associated virus (AAV) vectors with Cre- ... murine norovirus, Sendai virus, mouse adenovirus 1 and 2, ectromelia virus, lymphocytic choriomeningitis virus, pneumonia virus ... mouse hepatitis virus, mouse rotavirus, Theilers murine encephalomyelitis virus, ... Domenger, C. & Grimm, D. Next-generation AAV vectors-do not judge a virus (only) by its cover. Hum. Mol. Genet. 28, R3-R14 ( ...
... minute virus of mice, mouse hepatitis, mouse pneumonia, murine adenovirus, polyoma, reovirus-3, and Sendai. ... known-virus free mice inoculated with Sunday Canyon virus failed to respond with CF or HI antibodies against 12 murine viruses ... Virus Sections. Virus Name/Prototype. Original Source. Method of Isolation. Virus Properties. Antigenic Relationship. Biologic ... No serological relationship to any of 196 strains of arboviruses or 20 other viruses, mostly murine [1] . ...
Virus specific T cell infusions show promise for preventing HHV-6B reactivation in transplant patients. Review highlights the ... HHV-6 increases risk of an "idiopathic" pneumonia syndrome after HCT as does murine roseolovirus in a BMT mouse model. Early ... 89% of the virus found in the spinal fluid of HCT patients in the first 60 days is HHV-6. ... Virus specific T cell infusions show promise for preventing HHV-6B reactivation in transplant patients. ...
Spies, C., et al., "Effects of ethanol on cytokine production after surgery in a murine model of gram-negative pneumonia," ... Meyerholz, D., et al., "Chronic alcohol consumption increases the severity of murine influenza virus infections," Jour Immunol ... Prakash, O., et al., "Hepatitis C virus (HCV) and human immunodeficiency virus type 1 (HIV-1) infections in alcoholics," Front ... and Th2-phenotype cytokines in murine Klebsiella pneumonia," Alcoholism: Clin Experiment Res 1998; 22(3):621-27. ...
Oral Immunization of Mice with Live Pneumocystis murina Protects against Pneumocystis Pneumonia. J Immunol. 2016 Mar 15;196(6): ... Human Immunodeficiency Virus Infection and Host Defense in the Lungs. Semin Respir Crit Care Med. 2016 Apr;37(2):147-56. ... Alcohol consumption increases susceptibility to pneumococcal pneumonia in a humanized murine HIV model mediated by intestinal ... Title: Alcohol-induced Dysbiosis and HIV-associated Pneumonia Sponsor: R21 AA027199 NIH / NIAAA Welsh Role: Principal ...
Minute Virus of Mice. *Mouse Parvovirus. *Mouse Rotavirus. *Murine Cytomegalovirus. *Pneumonia Virus of Mice ...
... the EC50 value for murine hepatitis virus is 74 nM. It is in Phase III of Ebola virus treatment and has not been licensed or ... After the fifth day of hospitalization, the patient developed features of pneumonia in the lower lobe of the left lung. On the ... Scientific Research News , Research Progress of novel coronavirus Pneumonia (COVID-19) (III) ... the EC37 value for Ebola virus (EBOV) is 3 nM[50]; In HAE cells, the EC86 value for SARS-CoV and MERS-CoV was 1 nM; In delayed ...
It is separate but antigenically related to MURINE HEPATITIS VIRUS.. Methylmethacrylate. The methyl ester of methacrylic acid. ... A species of CORONAVIRUS causing pneumonia in newborn rats but a clinically inapparent infection in adults. ... An extranodal neoplasm, usually possessing an NK-cell phenotype and associated with EPSTEIN-BARR VIRUS. These lymphomas exhibit ...
In the murine model, RSV intranasal administrations were performed in wild-type and IL-17A-/- mice. Leukocytes and cytokines in ... BACKGROUND: IL-17A is a pleiotropic cytokine and intimately associated with asthma, but its role in respiratory syncytial virus ... RESULTS: IL-17A increased significantly in RSV-infected children and was positively associated with pneumonia severity. In the ... In the previous study, we found that tissue-resident memory γδT cells were enriched both in human and murine uterus and ...
Anti-CD3 antibody decreases inflammation and improves outcome in a murine model of Pneumocystis pneumonia.﻽. Bhagwat SP, Wright ... Human immunodeficiency virus type 1 (HIV-1) gp120-specific antibodies in neonates receiving an HIV-1 recombinant gp120 vaccine. ... Passive intranasal monoclonal antibody prophylaxis against murine Pneumocystis carinii pneumonia.﻽. Gigliotti F, Haidaris CG, ... Interleukin-6 production in a murine model of Pneumocystis carinii pneumonia: relation to resistance and inflammatory response. ...
In studies done at CDC, in cooperation with Cutter Laboratories, AIDS virus was added to factor VIII concentrate (virus titer ... Pneumocystis carinii pneumonia among persons with hemophilia A. MMWR 1982;31:365-7.. *Tsang VC, Peralta JM, Simons AR. Enzyme- ... A recently published study evaluated the thermostability of murine retroviruses inocculated into factor concentrates, using a ... Enck RE, Betts RF, Brown MR, Miller G. Viral serology (hepatitis B virus, cytomegalovirus, Epstein-Barr virus) and abnormal ...
After resolution of primary pneumonia, murine alveolar macrophages (AMs) exhibited poor phagocytic capacity for several weeks. ... Sepsis and physical trauma can increase the susceptibility of patients to pneumonia. Roquilly and colleagues demonstrate that ... which suggests a potential strategy to prevent hospital-acquired pneumonia. ... Sepsis and trauma cause inflammation and elevated susceptibility to hospital-acquired pneumonia. As phagocytosis by macrophages ...
Production of infectious, cell-free virus was inhibited in a dose-dependent manner, with ID50 values in the range 0·9-1·5 μM ... Analysis of the effect of melittin on cell-associated virus production revealed decreased levels of Gag antigen and HIV-1 mRNAs ... on human immunodeficiency virus 1 (HIV-1) replication and gene expression in acutely infected cells at subtoxic concentrations ... in a murine pneumonia model. Journal of Virology 70:2431-2439 ... ICTV Virus Taxonomy Profile: Paramyxoviridae Bert Rima, Anne ...
Pneumonia Virus of Mice: Negative. Polyoma Virus: Negative. Reovirus Screen: Negative. Sendai Virus: Negative. Theilers Murine ... Murine Pathogen Tests*. Ectromelia/Mousepox Virus: Negative. Hantavirus: Negative. K Virus: Negative. Lactate Dehydrogenase- ... Mouse Hepatitis Virus: Negative. Mouse Minute Virus: Negative. Mouse Norovirus: Negative. Mouse Parvovirus: Negative. Mouse ... Elevating Virus: Negative. Lymphocytic Choriomeningitis virus: Negative. Mouse Adenovirus: Negative. Mouse Cytomegalovirus: ...
Pneumocystis (PC) is an opportunistic fungal pathogen that causes pneumonia (PCP) in immunocompromised individuals and is one ... and HIV-infected individuals are still susceptible to PCP when they are not compliant with their HIV therapy or when the virus ...
... epiandrosterone and synthetic derivatives inhibit Junin virus replication in vitro. Virus Res 2008;135:203-212. View abstract. ... Daynes, R. A., Dudley, D. J., and Araneo, B. A. Regulation of murine lymphokine production in vivo. II. Dehydroepiandrosterone ... Kodama, M., Oyama, A., and Takagi, H. Control of interstitial pneumonia by drip infusion of megadose vitamin C, ... Risdon, G., Kumar, V., and Bennett, M. Differential effects of dehydroepiandrosterone (DHEA) on murine lymphopoiesis and ...
HHV-6 increases risk of an "idiopathic" pneumonia syndrome after HCT as does murine roseolovirus in a BMT mouse model. Early ... Named Murine Rosesolovirus (MRV), the virus causes severe depletion of CD4+ T cells and thymic necrosis in young mice. The ... HHV-6 increases risk of an "idiopathic" pneumonia syndrome after HCT as does murine roseolovirus in a BMT mouse model. Early ... A comparison of human, porcine and murine roseoloviruses Experts in human, murine and porcine roseolovirus combined forces to ...
A single immunization with modified vaccinia virus Ankara-based influenza virus H7 vaccine affords protection in the influenza ... Häggqvist B, Hultman P. Effects of deviating the Th2-response in murine mercury-induced autoimmunity towards a Th1-response. ... A(H7N9) pneumonia ferret model. J Infect Dis. 2015;211:791-800. (IHC-PS) ... of potent CD8 T cell cytotoxicity by specific targeting of antigen to cross-presenting dendritic cells in vivo via murine or ...
The case highlights the potential use of TTO in the treatment of common warts due to human papilloma virus.". Link. ... pneumonia].... This compound showed strong insecticidal activity against Reticulitermes speratus [termites], and it also had ... he strong cytotoxic effect of Thujaplicin on murine P388 lymphocytic leukemia cell line [CLL, chronic lymphocytic leukemia] ...
"Novel Subsets of Resident Lymphocytes in Murine Lungs Recovered from Pneumococcal Pneumonia". Carolina Lyon De Ana. ... "Investigating a Virus that Doesnt Exist: Generating a Minigenome System for Lloviu Virus". and. "The Effect of Adjuvants on ... Vaccinia virus hijacks EGFR signalling to enhance virus spread through rapid and directed infected cell motility. Nat. ... "Investigating the Role of Virus-Encoded Small RNAs in Ebola Virus Transcription Initiation". Stephen Ross, Cifuentes & ...
... as well as murine hepatitis virus (MHV), bovine coronavirus, porcine hemagglutinating encephalomyelitis virus (HEV), equine ... SARS-CoV, the causal pathogen of severe acute respiratory syndrome (SARS), caused a large outbreak of this severe pneumonia ... Albuquerque, N. D., Baig E., Ma X., Zhang J., He W., Rowe A., et al. (2006). Murine Hepatitis Virus Strain 1 Produces a ... Albuquerque, N D., et al. "Murine Hepatitis Virus Strain 1 Produces a Clinically Relevant Model of Severe Acute Respiratory ...
Pneumonia and Sepsis in Critical Care: Navigating a Complex Patient Diagnostic Workup 0.75 CME / CE Credits ... Role of complement in murine corneal infection caused by Pseudomonas aeruginosa. Invest Ophthalmol Vis Sci. 1983 Feb. 24(2):237 ... Pseudomonas pericarditis and tamponade in an infant with human immunodeficency virus infection. Arch Pediatr Adolesc Med. 1997 ... Ventilator-associated pneumonia (VAP) caused by P aeruginosa is associated with higher mortality rates (estimated to be as high ...
Rabbit picobirnavirus Sendai virus Seoul virus Simian virus 5 Theilers murine encephalomyelitis virus Toolans H-1 virus ... Parainfluenza virus (type 3) Parvovirus NS-1 Pneumocystis carinii Pneumonia virus of mice Polyoma virus Prospect Hill virus ... A virus Kilham rat virus Lactate dehydrogenase-elevating virus Ljungan virus Lymphocytic choriomeningitis virus Minute virus of ... Mouse thymic virus Murine norovirus Mycoplasma arthritidis Mycoplasma pulmonis Parainfluenza virus (type 1) Parainfluenza virus ...
What type (DNA or RNA) of virus is Pneumonia virus of mice (PVM)? ... Reovirus and murine rotavirus (aka epizootic diarrhea of infant mice virus)*, p72 ... What family of viruses does Sendai virus belong and to which human virus is it antigenically related. ... What relationship can Pneumonia Virus of Mice have with Pneomocystis carinii infection in immunodeficient mice? ...
Pneumonia virus of mice (PVM),. Reovirus type 3 (Reo 3),. Theilers mouse encephalomielitis virus (TMEV) ... Pneumocystis murina,. Pseudomonas aeruginosa. Lactate dehydrogenase elevating virus (LDHEV),. Mouse adenovirus (MAV), ...
Lymphocytic Choriomeningitis Virus (LCMV), Minute Virus of Mice (MVM), Mycoplasma pulmonis (MP), Pneumonia Virus of Mice (PVM) ... Kilham rat virus, MHV, Murine norovirus, Mycoplasma pulmonis, Pasturella pneumotropica, Pneumocystis carinii, Pseudomonas ... Hantan Virus (HV), Lactate Dehydrogenase Elevating virus (LDHV), ... Lactate Dehydrgenase Elevating Virus (LDHV), Sendai and Tyzzers ...

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