A topically used antibiotic from a strain of Pseudomonas fluorescens. It has shown excellent activity against gram-positive staphylococci and streptococci. The antibiotic is used primarily for the treatment of primary and secondary skin disorders, nasal infections, and wound healing.
Semisolid preparations used topically for protective emollient effects or as a vehicle for local administration of medications. Ointment bases are various mixtures of fats, waxes, animal and plant oils and solid and liquid hydrocarbons.
An enzyme that activates isoleucine with its specific transfer RNA. EC 6.1.1.5.
Infections with bacteria of the genus STAPHYLOCOCCUS.
Potentially pathogenic bacteria found in nasal membranes, skin, hair follicles, and perineum of warm-blooded animals. They may cause a wide range of infections and intoxications.
Substances that reduce the growth or reproduction of BACTERIA.
The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.
Non-susceptibility of a microbe to the action of METHICILLIN, a semi-synthetic penicillin derivative.
An antibiotic isolated from the fermentation broth of Fusidium coccineum. (From Merck Index, 11th ed). It acts by inhibiting translocation during protein synthesis.
The ability of bacteria to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
A disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque.
Use of antibiotics before, during, or after a diagnostic, therapeutic, or surgical procedure to prevent infectious complications.
Infections to the skin caused by bacteria of the genus STAPHYLOCOCCUS.
A strain of Staphylococcus aureus that is non-susceptible to the action of METHICILLIN. The mechanism of resistance usually involves modification of normal or the presence of acquired PENICILLIN BINDING PROTEINS.
Catheters designed to be left within an organ or passage for an extended period of time.
A complex of cyclic peptide antibiotics produced by the Tracy-I strain of Bacillus subtilis. The commercial preparation is a mixture of at least nine bacitracins with bacitracin A as the major constituent. It is used topically to treat open infections such as infected eczema and infected dermal ulcers. (From Goodman and Gilman, The Pharmacological Basis of Therapeutics, 8th ed, p1140)
The condition of harboring an infective organism without manifesting symptoms of infection. The organism must be readily transmissible to another susceptible host.
Delivery of medications through the nasal mucosa.
Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).
Substances used on humans and other animals that destroy harmful microorganisms or inhibit their activity. They are distinguished from DISINFECTANTS, which are used on inanimate objects.
A part of the upper respiratory tract. It contains the organ of SMELL. The term includes the external nose, the nasal cavity, and the PARANASAL SINUSES.
INFLAMMATION of the PERITONEUM lining the ABDOMINAL CAVITY as the result of infectious, autoimmune, or chemical processes. Primary peritonitis is due to infection of the PERITONEAL CAVITY via hematogenous or lymphatic spread and without intra-abdominal source. Secondary peritonitis arises from the ABDOMINAL CAVITY itself through RUPTURE or ABSCESS of intra-abdominal organs.
A genus of gram-positive, facultatively anaerobic, coccoid bacteria. Its organisms occur singly, in pairs, and in tetrads and characteristically divide in more than one plane to form irregular clusters. Natural populations of Staphylococcus are found on the skin and mucous membranes of warm-blooded animals. Some species are opportunistic pathogens of humans and animals.
The proximal portion of the respiratory passages on either side of the NASAL SEPTUM. Nasal cavities, extending from the nares to the NASOPHARYNX, are lined with ciliated NASAL MUCOSA.
The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).

Emergence of mupirocin resistance in multiresistant Staphylococcus aureus clinical isolates belonging to Brazilian epidemic clone III::B:A. (1/232)

Mupirocin is a topical antimicrobial agent that has been successfully used to eradicate methicillin-resistant Staphylococcus aureus from the anterior nares and other sites of patients and health care personnel. This report describes the acquisition of a novel mupirocin resistance gene (ileS) by an epidemic MRSA clone that is geographically widespread in Brazil.  (+info)

Randomized, placebo-controlled, double-blind trial to evaluate the efficacy of mupirocin for eradicating carriage of methicillin-resistant Staphylococcus aureus. (2/232)

Mupirocin has been widely used for the clearance of nasal methicillin-resistant Staphylococcus aureus (MRSA) carriage during outbreaks, but no placebo-controlled trial has evaluated its value for eradicating MRSA carriage at multiple body sites in settings where MRSA is not epidemic. In a 1,500-bed teaching hospital with endemic MRSA, 102 patients colonized with MRSA were randomized into a double-blind, placebo-controlled trial and treated with either mupirocin (group M) or placebo (group P) applied to the anterior nares for 5 days; both groups used chlorhexidine soap for body washing. Follow-up screening, susceptibility testing, and genotyping were performed to evaluate treatment success, mupirocin or chlorhexidine resistance, and exogenous recolonization. At baseline, MRSA carriage was 60% in the nares, 38% in the groin, and 62% in other sites (skin lesions, urine). The MRSA eradication rate (all body sites) was 25% in group M (12 of 48 patients), compared to 18% in group P (9 of 50 patients; relative risk [RR], 0.72; 95% confidence interval [CI95], 0.33 to 1.55). At the end of follow-up, 44% of patients (19 of 43) were free of nasal MRSA in group M, compared to 23% (11 of 44) in group P (RR, 0.57; CI95, 0.31 to 1.04). Ten patients developed MRSA infections (three in group M and seven in group P). One mupirocin treatment failure was due to exogenous MRSA recolonization. No MRSA isolate showed chlorhexidine resistance or high-level mupirocin resistance; however, we observed an association (P = 0.003) between low-level mupirocin resistance at study entry (prevalence, 23%) and subsequent treatment failure in both study arms. These results suggest that nasal mupirocin is only marginally effective in the eradication of multisite MRSA carriage in a setting where MRSA is endemic.  (+info)

The antifungal activity of mupirocin. (3/232)

The antibacterial agent mupirocin (pseudomonic acid A) is used as a topical agent in the treatment of superficial infections by Gram-positive bacteria, particularly Staphylococcus aureus. However, we demonstrate here that the compound also inhibits the growth of a number of pathogenic fungi in vitro, including a range of dermatophytes and Pityrosporum spp. It inhibited the incorporation of amino acids and precursors of RNA, but not that of acetate, by Trichophyton mentagrophytes. It also inhibited the isoleucyl-tRNA synthetase from Candida albicans, indicating a mechanism of action similar to that in bacteria. When administered topically, mupirocin was efficacious in a T. mentagrophytes ringworm model in guinea pigs. These results suggest that mupirocin could have clinical utility for superficial infections caused by dermatophytes.  (+info)

Cost-effectiveness of prophylactic nasal mupirocin in patients undergoing peritoneal dialysis based on a randomized, placebo-controlled trial. (4/232)

The study objective was to measure the benefits of elimination of nasal carriage of Staphylococcus aureus by calcium mupirocin ointment in patients undergoing continuous ambulatory peritoneal dialysis. The design was a prospective, placebo-controlled, randomized clinical trial. The subjects were 267 patients recruited from nine renal units in Belgium, France and the UK. The main outcome measures were the rate of catheter exit site infection (ESI), rates of other infections and healthcare costs from the perspective of a hospital budget-holder. The rate of ESI caused by S. aureus was significantly reduced from one in 28.1 patient months to one in 99.3 patient months (P = 0.006) and there were also non-significant trends towards lower rates of ESI caused by any organism and peritonitis caused by S. aureus. In comparison with the placebo group, patients in the mupirocin group with ESI had lower antibiotic (P = 0.02) and hospitalization costs (P = 0.065). However, overall costs of antibiotic treatment, for all infections combined, were not significantly different (P = 0.2) and total antibiotic costs (including mupirocin) were significantly higher in the mupirocin group (P = 0.001). Mupirocin prophylaxis would have been cost-neutral if the rate of ESI increased to >75% in the placebo group, or if all healthcare costs increased by 40%, or if the cost of screening was reduced from Pound Sterling 15 to Pound Sterling 3 per patient, or if the cost of mupirocin treatment was reduced from Pound Sterling 93 to Pound Sterling 40 per patient year. In conclusion, savings in healthcare costs are unlikely to be sufficiently great to offset the cost of mupirocin and screening for nasal carriage of S. aureus. The decision about whether or not to implement mupirocin should depend on a local analysis of the value of preventing ESIs caused by S. aureus.  (+info)

A randomized clinical trial of mupirocin in the eradication of Staphylococcus aureus nasal carriage in human immunodeficiency virus disease. (5/232)

Seventy-six human immunodeficiency virus (HIV)-infected patients with Staphylococcus aureus nasal carriage were randomized to treatment groups receiving intranasal mupirocin or placebo twice daily for 5 days. Nasal cultures for S. aureus were obtained at 1, 2, 6, and 10 weeks after therapy. At 1 week, 88% of mupirocin-treated patients had negative nasal cultures compared with 8% in placebo patients (P<.001). The percentage of mupirocin-treated patients with persistently negative nasal cultures decreased over time (63%, 45%, and 29% at 2, 6, and 10 weeks, respectively) but remained significantly greater than the placebo group (3% at 2, 6, and 10 weeks). In mupirocin-treated patients, most (16/19) instances of nasal recolonization were with pretreatment strains (determined by means of by pulsed field gel electrophoresis); mupirocin resistance was not observed. Five days of treatment with mupirocin eliminated S. aureus nasal carriage in HIV-infected patients for several weeks; however, since the effect waned over time, intermittent dosing regimens should be considered for long-term eradication.  (+info)

Insights into editing from an ile-tRNA synthetase structure with tRNAile and mupirocin. (6/232)

Isoleucyl-transfer RNA (tRNA) synthetase (IleRS) joins Ile to tRNA(Ile) at its synthetic active site and hydrolyzes incorrectly acylated amino acids at its editing active site. The 2.2 angstrom resolution crystal structure of Staphylococcus aureus IleRS complexed with tRNA(Ile) and Mupirocin shows the acceptor strand of the tRNA(Ile) in the continuously stacked, A-form conformation with the 3' terminal nucleotide in the editing active site. To position the 3' terminus in the synthetic active site, the acceptor strand must adopt the hairpinned conformation seen in tRNA(Gln) complexed with its synthetase. The amino acid editing activity of the IleRS may result from the incorrect products shuttling between the synthetic and editing active sites, which is reminiscent of the editing mechanism of DNA polymerases.  (+info)

Outbreak of mupirocin-resistant staphylococci in a hospital in Warsaw, Poland, due to plasmid transmission and clonal spread of several strains. (7/232)

An outbreak of mupirocin-resistant (MuR) staphylococci was investigated in two wards of a large hospital in Warsaw, Poland. Fifty-three MuR isolates of Staphylococcus aureus, S. epidermidis, S. haemolyticus, S. xylosus, and S. capitis were identified over a 17-month survey which was carried out after introduction of the drug for the treatment of skin infections. The isolates were collected from patients with infections, environmental samples, and carriers; they constituted 19.5% of all staphylococcal isolates identified in the two wards during that time. Almost all the MuR isolates were also resistant to methicillin (methicillin-resistant S. aureus and methicillin-resistant coagulase-negative staphylococci). Seven of the outbreak isolates expressed a low-level-resistance phenotype (MuL), whereas the remaining majority of isolates were found to be highly resistant to mupirocin (MuH). The mupA gene, responsible for the MuH phenotype, has been assigned to three different polymorphic loci among the strains in the collection analyzed. The predominant polymorph, polymorph I (characterized by a mupA-containing EcoRI DNA fragment of about 16 kb), was located on a specific plasmid which was widely distributed among the entire staphylococcal population. All MuR S. aureus isolates were found to represent a single epidemic strain, which was clonally disseminated in both wards. The S. epidermidis population was much more diverse; however, at least four clusters of closely related isolates were identified, which suggested that some strains of this species were also clonally spread in the hospital environment. Six isolates of S. epidermidis were demonstrated to express the MuL and MuH resistance mechanisms simultaneously, and this is the first identification of such dual MuR phenotype-bearing strains. The outbreak was attributed to a high level and inappropriate use of mupirocin, and as a result the dermatological formulation of the drug has been removed from the hospital formulary.  (+info)

Efficacy of a new cream formulation of mupirocin: comparison with oral and topical agents in experimental skin infections. (8/232)

A new cream formulation of mupirocin developed to improve patient compliance was compared with systemic and topical antibiotics commonly used to treat primary and secondary skin infections. A mouse surgical wound model infected with Staphylococcus aureus or Streptococcus pyogenes was used. Topical treatment was applied at 4 and 10 h postinfection or oral treatment at a clinically relevant dose was administered 4, 8, and 12 h postinfection; treatments were continued three times daily for a further 3 days. Mupirocin cream was significantly more effective than (P < 0.01; two of eight studies) or not significantly different from (six of eight studies) mupirocin ointment in reducing bacterial numbers. Mupirocin cream was similar in efficacy to oral flucloxacillin but significantly more effective (P < 0.001) than oral erythromycin. It was also similar in efficacy to cephalexin against S. pyogenes but superior against S. aureus (P < 0.01). Mupirocin cream had a similar efficacy to fusidic acid cream against S. aureus but was significantly superior against S. pyogenes (P < 0.01). A hamster impetigo model infected with S. aureus was also used. Topical or oral treatment was administered at 24 and 30 h postinfection (also 36 h postinfection for oral therapy) and then three times daily for a further 2 days. On day 5, mupirocin cream was significantly more effective than mupirocin ointment in one study (P < 0.01) and of similar efficacy in the other two studies. Mupirocin cream was not significantly different from fusidic acid cream or neomycin-bacitracin cream, but it was significantly superior (P < 0.01) to oral erythromycin and cephalexin. Mupirocin cream was as effective as, or superior to, oral and other topical agents commonly used for skin infections.  (+info)

Staphylococcal infections can be classified into two categories:

1. Methicillin-Resistant Staphylococcus Aureus (MRSA) - This type of infection is resistant to many antibiotics and can cause severe skin infections, pneumonia, bloodstream infections and surgical site infections.

2. Methicillin-Sensitive Staphylococcus Aureus (MSSA) - This type of infection is not resistant to antibiotics and can cause milder skin infections, respiratory tract infections, sinusitis and food poisoning.

Staphylococcal infections are caused by the Staphylococcus bacteria which can enter the body through various means such as:

1. Skin cuts or open wounds
2. Respiratory tract infections
3. Contaminated food and water
4. Healthcare-associated infections
5. Surgical site infections

Symptoms of Staphylococcal infections may vary depending on the type of infection and severity, but they can include:

1. Skin redness and swelling
2. Increased pain or tenderness
3. Warmth or redness in the affected area
4. Pus or discharge
5. Fever and chills
6. Swollen lymph nodes
7. Shortness of breath

Diagnosis of Staphylococcal infections is based on physical examination, medical history, laboratory tests such as blood cultures, and imaging studies such as X-rays or CT scans.

Treatment of Staphylococcal infections depends on the type of infection and severity, but may include:

1. Antibiotics to fight the infection
2. Drainage of abscesses or pus collection
3. Wound care and debridement
4. Supportive care such as intravenous fluids, oxygen therapy, and pain management
5. Surgical intervention in severe cases.

Preventive measures for Staphylococcal infections include:

1. Good hand hygiene practices
2. Proper cleaning and disinfection of surfaces and equipment
3. Avoiding close contact with people who have Staphylococcal infections
4. Covering wounds and open sores
5. Proper sterilization and disinfection of medical equipment.

It is important to note that MRSA (methicillin-resistant Staphylococcus aureus) is a type of Staphylococcal infection that is resistant to many antibiotics, and can be difficult to treat. Therefore, early diagnosis and aggressive treatment are crucial to prevent complications and improve outcomes.

Some common types of staphylococcal skin infections include:

1. Boils: A boil is a red, swollen, and painful bump on the skin that is caused by an infection of a hair follicle or oil gland.
2. Abscesses: An abscess is a collection of pus that forms as a result of an infection. Staphylococcal abscesses can occur anywhere on the body and can be caused by a variety of factors, including cuts, burns, and insect bites.
3. Cellulitis: This is a bacterial infection of the skin and underlying tissues that can cause redness, swelling, and warmth in the affected area.
4. Furuncles: These are small, painful boils that occur under the skin, often on the face or neck.
5. Carbuncles: These are larger and more severe than furuncles, and can form in the armpits, groin, or other areas of the body.
6. Skin fold infections: These are infections that occur in skin folds, such as those found in obese individuals or those with skin conditions like eczema or dermatitis.

Staphylococcal skin infections can be caused by a variety of factors, including cuts, scrapes, insect bites, and contaminated tattoo or piercing equipment. They are typically treated with antibiotics, and in severe cases, may require surgical drainage of the infected area.

Preventive measures for staphylococcal skin infections include:

1. Practicing good hygiene, such as washing your hands regularly and thoroughly cleaning any cuts or scrapes.
2. Covering wounds with bandages to prevent germs from entering the body.
3. Avoiding sharing personal items, such as towels or razors, that may come into contact with infected skin.
4. Properly caring for and cleaning any tattoos or piercings.
5. Avoiding close contact with individuals who have staphylococcal infections.
6. Using mupirocin ointment or other antibiotic ointments to help prevent infection in individuals at high risk, such as those with skin conditions like eczema or dermatitis.
7. Using steroid-free topical products and avoiding the use of harsh soaps and cleansers that can strip the skin of its natural oils and make it more susceptible to infection.
8. Keeping wounds moist with antibiotic ointment and dressings to promote healing and prevent infection.

The symptoms of peritonitis can vary depending on the severity and location of the inflammation, but they may include:

* Abdominal pain and tenderness
* Fever
* Nausea and vomiting
* Diarrhea or constipation
* Loss of appetite
* Fatigue
* Weakness
* Low blood pressure

Peritonitis can be diagnosed through a physical examination, medical history, and diagnostic tests such as a CT scan, MRI or ultrasound. Treatment usually involves antibiotics to clear the infection and supportive care to manage symptoms. In severe cases, surgery may be required to remove any infected tissue or repair damaged organs.

Prompt medical attention is essential for effective treatment and prevention of complications such as sepsis, organ failure, and death.

Therefore, it is believed that mupirocin is constructed by a mixed type I and type II PKS system. The mupirocin cluster ... Mupirocin is inactive for most anaerobic bacteria, mycobacteria, mycoplasma, chlamydia, yeast, and fungi. Intranasal mupirocin ... Shortly after the clinical use of mupirocin began, strains of Staphylococcus aureus that were resistant to mupirocin emerged, ... in the 9-hydroxy-nonanoic acid portion of mupirocin. The 74 kb mupirocin gene cluster contains six multi-domain enzymes and ...
"mupirocin search results". DailyMed. Retrieved 12 March 2020. Richards DM, Brogden RN (February 1985). "Ceftazidime. A review ... Among these, albendazole, amoxicillin, amoxicillin-clavulanate, allopurinol, mercaptopurine, mupirocin, pyrimethamine, ... mupirocin, and ceftazidime for bacterial infections, zidovudine for HIV infection, valacyclovir for herpes virus infections, ...
Mupirocin is a topical antibiotic commonly used for superficial skin infections and has been approved by the FDA nasal ... "Mupirocin Monograph for Professionals". Drugs.com. Retrieved 2022-09-16. Mehta, Sapna; Hadley, Scott; Hutzler, Lorraine; Slover ... Typically, patients use chlorhexidine shampoo or body wash daily and mupirocin nasal spray twice daily. The duration of product ... This study determined decolonization with chlorhexidine and mupirocin of all patients without screening was the most effective ...
Mild cases may be treated with mupirocin ointments. In 95% of cases, a single 7-day antibiotic course results in resolution in ... Treatment is typically with antibiotic creams such as mupirocin or fusidic acid. Antibiotics by mouth, such as cefalexin, may ...
The use of mupirocin ointment can reduce the rate of infections due to nasal carriage of S. aureus. There is limited evidence ... One topical agent that is prescribed is Mupirocin, a protein synthesis inhibitor that is produced naturally by Pseudomonas ... Cochrane Wounds Group) (October 2008). "Mupirocin ointment for preventing Staphylococcus aureus infections in nasal carriers". ...
Such prescribed ointments include neosporin, fusidic acid, chloramphenicol and mupirocin. More severe cases of impetigo however ...
Fusidic acid is preferred over mupirocin in most cases due to less resistance to fusidic acid amongst Methicillin-sensitive ... Effective antibiotic options include clindamycin, erythromycin, mupirocin, and fusidic acid. Topical clindamycin is generally ... or mupirocin. Prevention efforts aim to keep the feet dry by using moisture-wicking shoes and socks as well as antiperspirants ...
Mupirocin 2% ointment can be effective at reducing the size of lesions. A secondary covering of clothing is preferred. As shown ... In skin infections and secondary infection sites, topical mupirocin is used successfully. For bacteremia and endocarditis, ...
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"Insights into editing from an ile-tRNA synthetase structure with tRNAile and mupirocin". Science. 285 (5430): 1074-7. doi: ...
Topical application of clobetasol, mupirocin, and gentamicin alternated with tacrolimus can be effective. Pyoderma gangrenosum ...
Topical antibiotics, such as mupirocin or neomycin/polymyxin B/bacitracin ointment may be prescribed. Oral antibiotics may also ...
The use of preventative nasal mupirocin is of unclear effect with respect to peritonitis. Of the three types of connection and ...
Aside from fusidic acid, neomycin, mupirocin, metronidazole, and chlorhexidine are alternative options in this scenario. ...
Mupirocin free acid and its salts and esters are agents currently used in creams, ointments, and sprays as a treatment of ... By culturing P. fluorescens, mupirocin (an antibiotic) can be produced, which has been found to be useful in treating skin, ear ... 4-diacetylphloroglucinol and the MRSA-active antibiotic mupirocin. 4-Hydroxyacetophenone monooxygenase is an enzyme found in P ...
... or Mupirocin against Staphylococcus aureus in vitro". The Journal of Antibiotics. 59 (5): 303-8. doi:10.1038/ja.2006.43. PMID ...
... that are exploited commercially such as Mupirocin). This works against staphylococcal and streptococcal infections. Pseudomonas ...
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Attempts to eradicate methicillin-resistant Staphylococcus aureus from a long-term-care facility with the use of mupirocin ... Staphylococcus aureus nasal colonization in a nursing home: eradication with mupirocin. Infect Control Hosp Epidemiol 1990;11(1 ...
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Clindamycin Dalbavancin Fusidic acid Mupirocin (topical) Omadacycline Oritavancin Tedizolid Telavancin Tigecycline (also covers ...
... acid D06AX02 Chloramphenicol D06AX04 Neomycin D06AX05 Bacitracin D06AX07 Gentamicin D06AX08 Tyrothricin D06AX09 Mupirocin ...
... and Sensicort-F Mometasone and mupirocin as Sensicort-B Mometasone and orbifloxacin and posaconazole for veterinary use as ... and clotrimazole and gentamicin for veterinary use as Mometamax and Mometavet Mometasone and clotrimazole and mupirocin as ...
R01AX01 Calcium hexamine thiocyanate R01AX02 Retinol R01AX03 Ipratropium bromide R01AX05 Ritiometan R01AX06 Mupirocin R01AX07 ...
Clopidogrel Alteplaseα Streptokinaseα Simvastatin Miconazole Selenium sulfide Sodium thiosulfate Terbinafine Mupirocin ...
Miconazole Terbinafine Mupirocin Potassium permanganate Silver sulfadiazine Betamethasone Calamine Hydrocortisone Benzoyl ...
... (UNII: D0GX863OA5) (MUPIROCIN - UNII:D0GX863OA5) MUPIROCIN. 20 mg in 1 g. ... Each gram of Mupirocin Ointment USP, 2% contains 20 mg mupirocin in a bland water miscible ointment base (polyethylene glycol ... Results of the following studies performed with mupirocin calcium or mupirocin sodium in vitro and in vivo did not indicate a ... approximately 60 mg mupirocin per day) on a mg/m2 basis and revealed no evidence of harm to the fetus due to mupirocin. There ...
Mupirocin: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Mupirocin is for external use only. Do not let mupirocin ointment get into your eyes, nose, or mouth, and do not swallow it. Do ... Mupirocin comes in an ointment that is applied to the skin. Mupirocin usually is applied three times a day for 1 to 2 weeks. ... Before using mupirocin,. *tell your doctor and pharmacist if you are allergic to mupirocin or any other drugs. ...
Mupirocin Mupirocin, an antibiotic, is used to treat impetigo as well as other skin infections caused by bacteria. ... ... Mupirocin comes in an ointment that is applied to the skin. Mupirocin usually is applied three times ... ... chlorhexidine Antibiotic ointment, such as bacitracin, polysporin, or mupirocin Sterile eyewash, such as contact lens saline ... nasal furuncles,nasal vestibulitis,cellulitis,cavernous sinus thrombosis,mupirocin ointment,infection of the nose ...
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... mupirocin is considered a low risk to the nursing infant.[1] Ensure that the infants skin does not come into direct contact ... Mupirocin No authors listed In: Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child ... Because less than 1% is absorbed after topical application, mupirocin is considered a low risk to the nursing infant.[1] Ensure ... Mupirocin applied topically to the nipples appears to be relatively ineffective as a treatment for sore, cracked nipples. ...
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Lee AS, Macedo-Vinas M, François P, Renzi G, Schrenzel J, Vernaz N. Impact of combined low-level mupirocin and genotypic ... 162, 163, 164] Topical antibiotics such as mupirocin or retapamulin may be used for superficial localized infections (ie, ...
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Mupirocin is a prescription antibiotic cream that doctors may use on deep burns and MRSA infections. Use as directed by your ... How do I use mupirocin?. Mupirocin is a cream that patients apply topically to the wound or infection site. In most cases, ... Are there any side effects of mupirocin cream?. It is not uncommon for patients to experience stinging after applying mupirocin ... Mupirocin is an antibacterial cream that requires a prescription. The brand name is Bactroban. Doctors may prescribe it for ...
Silver ions are released from the mupirocin-Ag complex (Mup-Ag) to exert a synergistic antibacterial activity with mupirocin. ... Effective decolonization strategy for mupirocin-resistant Staphylococcus aureus by TPGS-modified mupirocin-silver complex. ... In order to counteract MuRSA, we develop a d-α-tocopherol polyethylene glycol 1000 succinate (TPGS) modified mupirocin and ... Results manifest that our strategy reduces the concentration of mupirocin that induces 50% bacterial death from about 1000 â ...
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  • Mupirocin comes in an ointment that is applied to the skin. (medlineplus.gov)
  • Do not let mupirocin ointment get into your eyes, nose, or mouth, and do not swallow it. (medlineplus.gov)
  • A separate formulation, mupirocin nasal ointment, is available for intranasal use. (nih.gov)
  • As such, a prescription ointment with Bactroban (mupirocin) may be necessary. (allegromedical.com)
  • Ointments such as silver sulfadiazine and 2% mupirocin ointment are available for treating localized bacterial infections. (aaep.org)
  • This patient was treated with mupirocin ointment, applied 4 times daily. (contemporarypediatrics.com)
  • Mupirocin, an antibiotic, is used to treat impetigo as well as other skin infections caused by bacteria. (medlineplus.gov)
  • Mupirocin is a type of antibiotic. (lifevisionindia.com)
  • Mupirocin (formerly pseudomonic acid) is a naturally occurring antibiotic produced by Pseudomonas fluorescens active against most gram-positive cocci, including methicillin-sensitive and methicillin-resistant S aureus and most streptococci (but not enterococci). (mhmedical.com)
  • The trial evaluated whether daily bathing with the antiseptic soap chlorhexidine (CHG) - and in those patients with methicillin-resistant Staphylococcus aureus (MRSA), adding the nasal antibiotic mupirocin - more effectively reduced hospital-acquired bacterial infections than bathing with ordinary soap and water. (nih.gov)
  • Topical mupirocin, fusidic acid, and nadifloxacin are used in the treatment of superficial bacterial infections. (ijdd.in)
  • and the topical antibiotics mupirocin (launched 1985), a pseudomonic acid, and retapamulin ( 3 ), a pleuromutilin derivative. (nature.com)
  • 7. Development of microsponges for topical delivery of mupirocin. (nih.gov)
  • To compare the efficacy and safety profile of 2% mupirocin versus 2% fusidic acid versus 1% nadifloxacin cream in the treatment of superficial bacterial infections. (ijdd.in)
  • This study documents the equality in the comparative safety and efficacy of mupirocin, fusidic acid, and nadifloxacin in the treatment of uncomplicated superficial bacterial infections at our center. (ijdd.in)
  • For this portion of the study, all cultures will additionally undergo disk susceptibility testing for retapamulin, erythromycin, clindamycin (including D-test), trimethoprim sulfa, and mupirocin (5 mcg and 20 mcg disks). (drugpatentwatch.com)
  • High rates of mupirocin resistance have been observed in methicillin-resistant S aureus isolates from surgical intensive care unit patients, despite minimal in-hospital mupirocin use. (mhmedical.com)
  • The IDSA recommends the use of mupirocin with chlorhexidine preferentially over oral antibacterials for methicillin-resistant S aureus decolonization. (mhmedical.com)
  • Lower percentages of resistant strains of Staphylococcus aureus to mupirocin (11.88%) and ciprofloxacin (0.99%) were observed. (who.int)
  • Staphylococcus aureus , mupirocin susceptibility. (who.int)
  • Multidrug and Mupirocin Resistance in Environmental Methicillin-Resistant Staphylococcus aureus (MRSA) Isolates from Homes of People Diagnosed with Community-Onset MRSA Infection. (nih.gov)
  • If I am on a decolonizing MRSA regime using mupirocin in my nose, armpits, and groin folds should I not partake in sexual intercourse? (healthtap.com)
  • During a trial of patients with CO-MRSA infection, MRSA was isolated from the household environment at the baseline and 3 months later, following randomization of patients and household members to mupirocin-based decolonization therapy or an education control group. (nih.gov)
  • However, recurrent colonization occurs (50% at the end of 1 year), and when mupirocin is used long-term over months, resistance can emerge. (mhmedical.com)
  • Apply a small amount of mupirocin cream, with a cotton swab or gauze pad, to the affected area 3 times daily for 10 days. (nih.gov)
  • Mupirocin is equal to oral beta-lactams in the treatment of mild impetigo. (mhmedical.com)
  • tell your doctor and pharmacist if you are allergic to mupirocin or any other drugs. (medlineplus.gov)
  • These highlights do not include all the information needed to use MUPIROCIN CREAM safely and effectively. (nih.gov)
  • See full prescribing information for MUPIROCIN CREAM. (nih.gov)
  • Cream: 20 mg (2% w/w) of mupirocin per gram in 15-gram and 30-gram tubes. (nih.gov)
  • Known hypersensitivity to mupirocin or any of the excipients of mupirocin cream. (nih.gov)
  • Severe Allergic Reactions: Anaphylaxis, urticaria, angioedema, and generalized rash have been reported in patients treated with formulations of mupirocin, including mupirocin cream. (nih.gov)
  • Risk Associated with Mucosal Use: Mupirocin cream is not formulated for use on mucosal surfaces. (nih.gov)
  • Mupirocin cream USP is a white cream that contains 20 mg (2% w/w) of mupirocin per gram in an oil- and water-based emulsion, supplied in 15-gram and 30-gram tubes. (nih.gov)
  • In the event of a sensitization or severe local irritation from mupirocin cream, usage should be discontinued, and appropriate alternative therapy for the infection instituted. (nih.gov)
  • Studies demonstrate an associated reduction in postoperative staphylococcal lung infections in colonized patients treated with mupirocin . (mhmedical.com)
  • While no statistically significant difference between the two intervention groups was seen within the population overall, the researchers did find that one subset of patients - those with medical devices - experienced a substantial benefit if they received the CHG/mupirocin intervention. (nih.gov)
  • However, patients with medical devices, such as central venous catheters or lumbar drains, benefitted from the CHG/mupirocin intervention. (nih.gov)
  • This finding suggests the benefit of mupirocin is limited . (mhmedical.com)
  • mupirocin Reducing the temperature is approached the experiments generally require more time. (goldgreiner.de)