AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesAnthropology, Education, Sociology and Social PhenomenaTechnology, Industry, AgricultureInformation ScienceHealth Care
MupirocinOintmentsIsoleucine-tRNA LigaseStaphylococcal InfectionsStaphylococcus aureusAnti-Bacterial AgentsAdministration, TopicalMethicillin ResistanceFusidic AcidDrug Resistance, BacterialChlorhexidineAntibiotic ProphylaxisStaphylococcal Skin InfectionsMethicillin-Resistant Staphylococcus aureusCatheters, IndwellingBacitracinCarrier StateAdministration, IntranasalMicrobial Sensitivity TestsAnti-Infective Agents, LocalNosePeritonitisStaphylococcusNasal CavityDrug Resistance, MicrobialSelf-Help GroupsPsychotherapy, GroupSocial SupportInternetInsurance, DisabilityUnited States Social Security AdministrationSocial SecurityDrug ContaminationFatigue Syndrome, ChronicPleurodynia, EpidemicBipolar DisorderAttention Deficit Disorder with HyperactivityAmyotrophic Lateral SclerosisGastroesophageal RefluxPetrolatumOintment BasesNasal MucosaProduct LabelingTriamcinolone AcetonideCetirizineTriamcinoloneHistamine H1 Antagonists, Non-SedatingDrug LabelingLoratadineSkin UlcerSucralfatePubMedPeriodicals as TopicBooks
Mupirocin
A topically used antibiotic from a strain of Pseudomonas fluorescens. It has shown excellent activity against gram-positive staphylococci and streptococci. The antibiotic is used primarily for the treatment of primary and secondary skin disorders, nasal infections, and wound healing.
Ointments
Semisolid preparations used topically for protective emollient effects or as a vehicle for local administration of medications. Ointment bases are various mixtures of fats, waxes, animal and plant oils and solid and liquid hydrocarbons.
Isoleucine-tRNA Ligase
An enzyme that activates isoleucine with its specific transfer RNA. EC 6.1.1.5.
Staphylococcal Infections
Infections with bacteria of the genus STAPHYLOCOCCUS.
Staphylococcus aureus
Potentially pathogenic bacteria found in nasal membranes, skin, hair follicles, and perineum of warm-blooded animals. They may cause a wide range of infections and intoxications.
Anti-Bacterial Agents
Substances that reduce the growth or reproduction of BACTERIA.
Administration, Topical
The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.
Methicillin Resistance
Non-susceptibility of a microbe to the action of METHICILLIN, a semi-synthetic penicillin derivative.
Fusidic Acid
An antibiotic isolated from the fermentation broth of Fusidium coccineum. (From Merck Index, 11th ed). It acts by inhibiting translocation during protein synthesis.
Drug Resistance, Bacterial
The ability of bacteria to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
Chlorhexidine
A disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque.
Antibiotic Prophylaxis
Use of antibiotics before, during, or after a diagnostic, therapeutic, or surgical procedure to prevent infectious complications.
Staphylococcal Skin Infections
Infections to the skin caused by bacteria of the genus STAPHYLOCOCCUS.
Methicillin-Resistant Staphylococcus aureus
A strain of Staphylococcus aureus that is non-susceptible to the action of METHICILLIN. The mechanism of resistance usually involves modification of normal or the presence of acquired PENICILLIN BINDING PROTEINS.
Catheters, Indwelling
Catheters designed to be left within an organ or passage for an extended period of time.
Bacitracin
A complex of cyclic peptide antibiotics produced by the Tracy-I strain of Bacillus subtilis. The commercial preparation is a mixture of at least nine bacitracins with bacitracin A as the major constituent. It is used topically to treat open infections such as infected eczema and infected dermal ulcers. (From Goodman and Gilman, The Pharmacological Basis of Therapeutics, 8th ed, p1140)
Carrier State
The condition of harboring an infective organism without manifesting symptoms of infection. The organism must be readily transmissible to another susceptible host.
Administration, Intranasal
Delivery of medications through the nasal mucosa.
Microbial Sensitivity Tests
Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).
Anti-Infective Agents, Local
Substances used on humans and other animals that destroy harmful microorganisms or inhibit their activity. They are distinguished from DISINFECTANTS, which are used on inanimate objects.
Nose
A part of the upper respiratory tract. It contains the organ of SMELL. The term includes the external nose, the nasal cavity, and the PARANASAL SINUSES.
Peritonitis
INFLAMMATION of the PERITONEUM lining the ABDOMINAL CAVITY as the result of infectious, autoimmune, or chemical processes. Primary peritonitis is due to infection of the PERITONEAL CAVITY via hematogenous or lymphatic spread and without intra-abdominal source. Secondary peritonitis arises from the ABDOMINAL CAVITY itself through RUPTURE or ABSCESS of intra-abdominal organs.
Staphylococcus
A genus of gram-positive, facultatively anaerobic, coccoid bacteria. Its organisms occur singly, in pairs, and in tetrads and characteristically divide in more than one plane to form irregular clusters. Natural populations of Staphylococcus are found on the skin and mucous membranes of warm-blooded animals. Some species are opportunistic pathogens of humans and animals.
Nasal Cavity
The proximal portion of the respiratory passages on either side of the NASAL SEPTUM. Nasal cavities, extending from the nares to the NASOPHARYNX, are lined with ciliated NASAL MUCOSA.
Drug Resistance, Microbial
The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
Self-Help Groups
Organizations which provide an environment encouraging social interactions through group activities or individual relationships especially for the purpose of rehabilitating or supporting patients, individuals with common health problems, or the elderly. They include therapeutic social clubs.
Psychotherapy, Group
A form of therapy in which two or more patients participate under the guidance of one or more psychotherapists for the purpose of treating emotional disturbances, social maladjustments, and psychotic states.
Social Support
Support systems that provide assistance and encouragement to individuals with physical or emotional disabilities in order that they may better cope. Informal social support is usually provided by friends, relatives, or peers, while formal assistance is provided by churches, groups, etc.
Internet
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
Insurance, Disability
Insurance designed to compensate persons who lose wages because of illness or injury; insurance providing periodic payments that partially replace lost wages, salary, or other income when the insured is unable to work because of illness, injury, or disease. Individual and group disability insurance are two types of such coverage. (From Facts on File Dictionary of Health Care Management, 1988, p207)
United States Social Security Administration
An independent agency within the Executive Branch of the United States Government. It administers a national social insurance program whereby employees, employers, and the self-employed pay contributions into pooled trust funds. Part of the contributions go into a separate hospital insurance trust fund for workers at age 65 to provide help with medical expenses. Other programs include the supplemental social security income program for the aged, blind, and disabled and the Old Age Survivors and Disability Insurance Program. It became an independent agency March 31, 1995. It had previously been part of the Department of Health, Education, and Welfare, later the Department of Health and Human Services. (From United States Government Manual, 1994-95)
Social Security
Government sponsored social insurance programs.
Drug Contamination
The presence of organisms, or any foreign material that makes a drug preparation impure.
Fatigue Syndrome, Chronic
A syndrome characterized by persistent or recurrent fatigue, diffuse musculoskeletal pain, sleep disturbances, and subjective cognitive impairment of 6 months duration or longer. Symptoms are not caused by ongoing exertion; are not relieved by rest; and result in a substantial reduction of previous levels of occupational, educational, social, or personal activities. Minor alterations of immune, neuroendocrine, and autonomic function may be associated with this syndrome. There is also considerable overlap between this condition and FIBROMYALGIA. (From Semin Neurol 1998;18(2):237-42; Ann Intern Med 1994 Dec 15;121(12): 953-9)
Pleurodynia, Epidemic
An acute, febrile, infectious disease generally occurring in epidemics. It is usually caused by coxsackieviruses B and sometimes by coxsackieviruses A; echoviruses; or other enteroviruses.
Bipolar Disorder
A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.
Attention Deficit Disorder with Hyperactivity
A behavior disorder originating in childhood in which the essential features are signs of developmentally inappropriate inattention, impulsivity, and hyperactivity. Although most individuals have symptoms of both inattention and hyperactivity-impulsivity, one or the other pattern may be predominant. The disorder is more frequent in males than females. Onset is in childhood. Symptoms often attenuate during late adolescence although a minority experience the full complement of symptoms into mid-adulthood. (From DSM-V)
Amyotrophic Lateral Sclerosis
A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
Gastroesophageal Reflux
Retrograde flow of gastric juice (GASTRIC ACID) and/or duodenal contents (BILE ACIDS; PANCREATIC JUICE) into the distal ESOPHAGUS, commonly due to incompetence of the LOWER ESOPHAGEAL SPHINCTER.
Petrolatum
A colloidal system of semisolid hydrocarbons obtained from PETROLEUM. It is used as an ointment base, topical protectant, and lubricant.
Ointment Bases
Various mixtures of fats, waxes, animal and plant oils and solid and liquid hydrocarbons; vehicles for medicinal substances intended for external application; there are four classes: hydrocarbon base, absorption base, water-removable base and water-soluble base; several are also emollients.
Nasal Mucosa
The mucous lining of the NASAL CAVITY, including lining of the nostril (vestibule) and the OLFACTORY MUCOSA. Nasal mucosa consists of ciliated cells, GOBLET CELLS, brush cells, small granule cells, basal cells (STEM CELLS) and glands containing both mucous and serous cells.
Product Labeling
Use of written, printed, or graphic materials upon or accompanying a product or its container or wrapper. It includes purpose, effect, description, directions, hazards, warnings, and other relevant information.
Triamcinolone Acetonide
An esterified form of TRIAMCINOLONE. It is an anti-inflammatory glucocorticoid used topically in the treatment of various skin disorders. Intralesional, intramuscular, and intra-articular injections are also administered under certain conditions.
Cetirizine
A potent second-generation histamine H1 antagonist that is effective in the treatment of allergic rhinitis, chronic urticaria, and pollen-induced asthma. Unlike many traditional antihistamines, it does not cause drowsiness or anticholinergic side effects.
Triamcinolone
A glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. (From Martindale, The Extra Pharmacopoeia, 30th ed, p739)
Histamine H1 Antagonists, Non-Sedating
A class of non-sedating drugs that bind to but do not activate histamine receptors (DRUG INVERSE AGONISM), thereby blocking the actions of histamine or histamine agonists. These antihistamines represent a heterogenous group of compounds with differing chemical structures, adverse effects, distribution, and metabolism. Compared to the early (first generation) antihistamines, these non-sedating antihistamines have greater receptor specificity, lower penetration of BLOOD-BRAIN BARRIER, and are less likely to cause drowsiness or psychomotor impairment.
Drug Labeling
Use of written, printed, or graphic materials upon or accompanying a drug container or wrapper. It includes contents, indications, effects, dosages, routes, methods, frequency and duration of administration, warnings, hazards, contraindications, side effects, precautions, and other relevant information.
Loratadine
A second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (HISTAMINE H1 ANTAGONISTS) it lacks central nervous system depressing effects such as drowsiness.
Skin Ulcer
Sucralfate
A basic aluminum complex of sulfated sucrose.
PubMed
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
Periodicals as Topic
A publication issued at stated, more or less regular, intervals.
Books

Emergence of mupirocin resistance in multiresistant Staphylococcus aureus clinical isolates belonging to Brazilian epidemic clone III::B:A. (1/232)

Mupirocin is a topical antimicrobial agent that has been successfully used to eradicate methicillin-resistant Staphylococcus aureus from the anterior nares and other sites of patients and health care personnel. This report describes the acquisition of a novel mupirocin resistance gene (ileS) by an epidemic MRSA clone that is geographically widespread in Brazil.  (+info)

Randomized, placebo-controlled, double-blind trial to evaluate the efficacy of mupirocin for eradicating carriage of methicillin-resistant Staphylococcus aureus. (2/232)

Mupirocin has been widely used for the clearance of nasal methicillin-resistant Staphylococcus aureus (MRSA) carriage during outbreaks, but no placebo-controlled trial has evaluated its value for eradicating MRSA carriage at multiple body sites in settings where MRSA is not epidemic. In a 1,500-bed teaching hospital with endemic MRSA, 102 patients colonized with MRSA were randomized into a double-blind, placebo-controlled trial and treated with either mupirocin (group M) or placebo (group P) applied to the anterior nares for 5 days; both groups used chlorhexidine soap for body washing. Follow-up screening, susceptibility testing, and genotyping were performed to evaluate treatment success, mupirocin or chlorhexidine resistance, and exogenous recolonization. At baseline, MRSA carriage was 60% in the nares, 38% in the groin, and 62% in other sites (skin lesions, urine). The MRSA eradication rate (all body sites) was 25% in group M (12 of 48 patients), compared to 18% in group P (9 of 50 patients; relative risk [RR], 0.72; 95% confidence interval [CI95], 0.33 to 1.55). At the end of follow-up, 44% of patients (19 of 43) were free of nasal MRSA in group M, compared to 23% (11 of 44) in group P (RR, 0.57; CI95, 0.31 to 1.04). Ten patients developed MRSA infections (three in group M and seven in group P). One mupirocin treatment failure was due to exogenous MRSA recolonization. No MRSA isolate showed chlorhexidine resistance or high-level mupirocin resistance; however, we observed an association (P = 0.003) between low-level mupirocin resistance at study entry (prevalence, 23%) and subsequent treatment failure in both study arms. These results suggest that nasal mupirocin is only marginally effective in the eradication of multisite MRSA carriage in a setting where MRSA is endemic.  (+info)

The antifungal activity of mupirocin. (3/232)

The antibacterial agent mupirocin (pseudomonic acid A) is used as a topical agent in the treatment of superficial infections by Gram-positive bacteria, particularly Staphylococcus aureus. However, we demonstrate here that the compound also inhibits the growth of a number of pathogenic fungi in vitro, including a range of dermatophytes and Pityrosporum spp. It inhibited the incorporation of amino acids and precursors of RNA, but not that of acetate, by Trichophyton mentagrophytes. It also inhibited the isoleucyl-tRNA synthetase from Candida albicans, indicating a mechanism of action similar to that in bacteria. When administered topically, mupirocin was efficacious in a T. mentagrophytes ringworm model in guinea pigs. These results suggest that mupirocin could have clinical utility for superficial infections caused by dermatophytes.  (+info)

Cost-effectiveness of prophylactic nasal mupirocin in patients undergoing peritoneal dialysis based on a randomized, placebo-controlled trial. (4/232)

The study objective was to measure the benefits of elimination of nasal carriage of Staphylococcus aureus by calcium mupirocin ointment in patients undergoing continuous ambulatory peritoneal dialysis. The design was a prospective, placebo-controlled, randomized clinical trial. The subjects were 267 patients recruited from nine renal units in Belgium, France and the UK. The main outcome measures were the rate of catheter exit site infection (ESI), rates of other infections and healthcare costs from the perspective of a hospital budget-holder. The rate of ESI caused by S. aureus was significantly reduced from one in 28.1 patient months to one in 99.3 patient months (P = 0.006) and there were also non-significant trends towards lower rates of ESI caused by any organism and peritonitis caused by S. aureus. In comparison with the placebo group, patients in the mupirocin group with ESI had lower antibiotic (P = 0.02) and hospitalization costs (P = 0.065). However, overall costs of antibiotic treatment, for all infections combined, were not significantly different (P = 0.2) and total antibiotic costs (including mupirocin) were significantly higher in the mupirocin group (P = 0.001). Mupirocin prophylaxis would have been cost-neutral if the rate of ESI increased to >75% in the placebo group, or if all healthcare costs increased by 40%, or if the cost of screening was reduced from Pound Sterling 15 to Pound Sterling 3 per patient, or if the cost of mupirocin treatment was reduced from Pound Sterling 93 to Pound Sterling 40 per patient year. In conclusion, savings in healthcare costs are unlikely to be sufficiently great to offset the cost of mupirocin and screening for nasal carriage of S. aureus. The decision about whether or not to implement mupirocin should depend on a local analysis of the value of preventing ESIs caused by S. aureus.  (+info)

A randomized clinical trial of mupirocin in the eradication of Staphylococcus aureus nasal carriage in human immunodeficiency virus disease. (5/232)

Seventy-six human immunodeficiency virus (HIV)-infected patients with Staphylococcus aureus nasal carriage were randomized to treatment groups receiving intranasal mupirocin or placebo twice daily for 5 days. Nasal cultures for S. aureus were obtained at 1, 2, 6, and 10 weeks after therapy. At 1 week, 88% of mupirocin-treated patients had negative nasal cultures compared with 8% in placebo patients (P<.001). The percentage of mupirocin-treated patients with persistently negative nasal cultures decreased over time (63%, 45%, and 29% at 2, 6, and 10 weeks, respectively) but remained significantly greater than the placebo group (3% at 2, 6, and 10 weeks). In mupirocin-treated patients, most (16/19) instances of nasal recolonization were with pretreatment strains (determined by means of by pulsed field gel electrophoresis); mupirocin resistance was not observed. Five days of treatment with mupirocin eliminated S. aureus nasal carriage in HIV-infected patients for several weeks; however, since the effect waned over time, intermittent dosing regimens should be considered for long-term eradication.  (+info)

Insights into editing from an ile-tRNA synthetase structure with tRNAile and mupirocin. (6/232)

Isoleucyl-transfer RNA (tRNA) synthetase (IleRS) joins Ile to tRNA(Ile) at its synthetic active site and hydrolyzes incorrectly acylated amino acids at its editing active site. The 2.2 angstrom resolution crystal structure of Staphylococcus aureus IleRS complexed with tRNA(Ile) and Mupirocin shows the acceptor strand of the tRNA(Ile) in the continuously stacked, A-form conformation with the 3' terminal nucleotide in the editing active site. To position the 3' terminus in the synthetic active site, the acceptor strand must adopt the hairpinned conformation seen in tRNA(Gln) complexed with its synthetase. The amino acid editing activity of the IleRS may result from the incorrect products shuttling between the synthetic and editing active sites, which is reminiscent of the editing mechanism of DNA polymerases.  (+info)

Outbreak of mupirocin-resistant staphylococci in a hospital in Warsaw, Poland, due to plasmid transmission and clonal spread of several strains. (7/232)

An outbreak of mupirocin-resistant (MuR) staphylococci was investigated in two wards of a large hospital in Warsaw, Poland. Fifty-three MuR isolates of Staphylococcus aureus, S. epidermidis, S. haemolyticus, S. xylosus, and S. capitis were identified over a 17-month survey which was carried out after introduction of the drug for the treatment of skin infections. The isolates were collected from patients with infections, environmental samples, and carriers; they constituted 19.5% of all staphylococcal isolates identified in the two wards during that time. Almost all the MuR isolates were also resistant to methicillin (methicillin-resistant S. aureus and methicillin-resistant coagulase-negative staphylococci). Seven of the outbreak isolates expressed a low-level-resistance phenotype (MuL), whereas the remaining majority of isolates were found to be highly resistant to mupirocin (MuH). The mupA gene, responsible for the MuH phenotype, has been assigned to three different polymorphic loci among the strains in the collection analyzed. The predominant polymorph, polymorph I (characterized by a mupA-containing EcoRI DNA fragment of about 16 kb), was located on a specific plasmid which was widely distributed among the entire staphylococcal population. All MuR S. aureus isolates were found to represent a single epidemic strain, which was clonally disseminated in both wards. The S. epidermidis population was much more diverse; however, at least four clusters of closely related isolates were identified, which suggested that some strains of this species were also clonally spread in the hospital environment. Six isolates of S. epidermidis were demonstrated to express the MuL and MuH resistance mechanisms simultaneously, and this is the first identification of such dual MuR phenotype-bearing strains. The outbreak was attributed to a high level and inappropriate use of mupirocin, and as a result the dermatological formulation of the drug has been removed from the hospital formulary.  (+info)

Efficacy of a new cream formulation of mupirocin: comparison with oral and topical agents in experimental skin infections. (8/232)

A new cream formulation of mupirocin developed to improve patient compliance was compared with systemic and topical antibiotics commonly used to treat primary and secondary skin infections. A mouse surgical wound model infected with Staphylococcus aureus or Streptococcus pyogenes was used. Topical treatment was applied at 4 and 10 h postinfection or oral treatment at a clinically relevant dose was administered 4, 8, and 12 h postinfection; treatments were continued three times daily for a further 3 days. Mupirocin cream was significantly more effective than (P < 0.01; two of eight studies) or not significantly different from (six of eight studies) mupirocin ointment in reducing bacterial numbers. Mupirocin cream was similar in efficacy to oral flucloxacillin but significantly more effective (P < 0.001) than oral erythromycin. It was also similar in efficacy to cephalexin against S. pyogenes but superior against S. aureus (P < 0.01). Mupirocin cream had a similar efficacy to fusidic acid cream against S. aureus but was significantly superior against S. pyogenes (P < 0.01). A hamster impetigo model infected with S. aureus was also used. Topical or oral treatment was administered at 24 and 30 h postinfection (also 36 h postinfection for oral therapy) and then three times daily for a further 2 days. On day 5, mupirocin cream was significantly more effective than mupirocin ointment in one study (P < 0.01) and of similar efficacy in the other two studies. Mupirocin cream was not significantly different from fusidic acid cream or neomycin-bacitracin cream, but it was significantly superior (P < 0.01) to oral erythromycin and cephalexin. Mupirocin cream was as effective as, or superior to, oral and other topical agents commonly used for skin infections.  (+info)

Detection of mupirocin-resistant Staphylococcus aureus isolated from skin infections<...Detection of mupirocin-resistant Staphylococcus aureus isolated from skin infections<...
TY - JOUR. T1 - Detection of mupirocin-resistant Staphylococcus aureus isolated from skin infections. AU - Akiyama, Hisanori. AU - Yamasaki, Osamu. AU - Kanzaki, Hiroko. AU - Tada, Joji. AU - Arata, Jiro. PY - 1998/6. Y1 - 1998/6. N2 - We examined the MIC of mupirocin against Staphylococcus aureus strains isolated from skin infections between April 1996 and August 1997. None of the 32 S. aureus strains collected between April 1996 and September 1996 showed mupirocin-resistance, but 3 of the 58 S. aureus strains collected between October 1996 and August 1997 were found to be mupirocin-resistant with a MIC of 32 μg/mL. The 3 patients from whom the mupirocin-resistant S. aureus strains were isolated were outpatients with no previous mupirocin ointment treatment. The 3 mupirocin-resistant S. aureus strains were regarded as different strains on the basis of their coagulase typing, enterotoxin production, and antibiotic sensitivity. Our results suggest that the emergence of mupirocin-resistant S. ...
https://okayama.pure.elsevier.com/en/publications/detection-of-mupirocin-resistant-staphylococcus-aureus-isolated-f
Mupirocin resistance in nasal isolates of Staphylococci from health care workers :National Journal for Basic Medical ScienceMupirocin resistance in nasal isolates of Staphylococci from health care workers :National Journal for Basic Medical Science
Context: Application of mupirocin to the anterior nares of patients colonized with Staphylococci eliminates the carriage of these organisms and is important in preventing the spread and development of Staphylococcal infection. There are several reports of Staphylococcal resistance to mupirocin.. Aim: This study was carried out primarily to determine the prevalence of low level and high-level mupirocin resistance in Staphylococcus aureus and coagulase-negative Staphylococci (CONS) and secondarily to compare its association with methicillin resistance.. Materials and Methods: Study sample included nasal swabs from a total of 206 subjects, which consisted of 104 medical students and 102 health care workers. Resistance to mupirocin was detected by disc diffusion method of Kirby Bauer using 5 μg and 200 μg mupirocin discs. Statistical analysis was done by Z test.. Results: In the present study, low-level mupirocin resistance was seen in 1 (2.23%) of methicillin-resistant Staphylococcus aureus ...
http://njbms.com/micro-biology/mupirocin-resistance-in-nasal-isolates-of-staphylococci-from-health-care-workers/
MRSA Information: The Emergence of Mupirocin Resistance among Clinical Isolates of Methicillin-Resistant Staphylococcus aureus...MRSA Information: The Emergence of Mupirocin Resistance among Clinical Isolates of Methicillin-Resistant Staphylococcus aureus...
The objective of the study was to investigate the trend of mupirocin resistance among methicillin-resistant Staphylococcus aureus (MRSA) in Trinidad. No premarketing susceptibility surveillance was ever done following the introduction of mupirocin in 1986. A total of 188 MRSA strains recovered over a 2-year period from various body sites were tested for mupirocin resistance via the disc diffusion method. The major sources of MRSA were surgical site infections (74.0%) and bloodstream infections (8.0%). High-level and low-level mupirocin resistance were detected in 26.1 and 44.1% of MRSA stains, respectively. Resistances to other non-beta-lactam antibiotics were also high. Ninety-eight percent of all MRSA were resistant to erythromycin. This was followed by resistance rates of 96.8, 95.2, 94.1, 93.6, and 93.1%, for gentamicin, ciprofloxacin, amikacin and tobramycin, co-trimoxazole, and tetracycline, respectively. No MRSA strains were found to be resistant to vancomycin, linezolid, and ...
http://mrsainformation.blogspot.com/2008/03/emergence-of-mupirocin-resistance-among.html
Antibacterial activity of mupirocin (pseudomonic acid), a new antibiotic for topical use. | Antimicrobial Agents and...Antibacterial activity of mupirocin (pseudomonic acid), a new antibiotic for topical use. | Antimicrobial Agents and...
Mupirocin (pseudomonic acid A), an antibiotic produced by Pseudomonas fluorescens, showed a high level of activity against staphylococci and streptococci and against certain gram-negative bacteria, including Haemophilus influenzae and Neisseria gonorrhoeae, but was much less active against most gram-negative bacilli an anaerobes. Nearly all clinical isolates of Staphylococcus aureus and Staphylococcus epidermidis, including multiply resistant strains, were susceptible (mupirocin MIC, less than or equal to 0.5 microgram/ml). There was no cross-resistance between mupirocin and clinically available antibiotics, and the selection of resistant variants in vitro occurred at a low frequency. Mupirocin was highly bound (95% bound) to the protein of human serum, and activity was reduced 10- to 20-fold in the presence of human serum. The activity of mupirocin was not greatly influenced by inoculum size but was significantly enhanced in acid medium. In tests of bactericidal activity, MBCs were 8- to ...
https://aac.asm.org/content/27/4/495?ijkey=7837fad333c1c0839d12fb7b5c7002acc25e3864&keytype2=tf_ipsecsha
bactroban / GENERIC MUPIROCINbactroban / GENERIC MUPIROCIN
how to pronounce mupirocin, how to use mupirocin ointment, how does mupirocin work, how to apply mupirocin in nose, how to apply mupirocin ointment in the nose, how long does mupirocin take to...
http://www.blogigo.com/bactroban
Mupirocin cream (Generic Bactroban) for skin infections | Buying SkinCare Medications OnlineMupirocin cream (Generic Bactroban) for skin infections | Buying SkinCare Medications Online
Mupirocin is definitely an antibacterial lotion/lotion that will be used-to handle little regions of skin disease. Its occasionally used-to handle attacks for example impetigo in children. It functions by eliminating the viruses (microorganisms) evoking the disease.. Mupirocin can be used particularly to deal with attacks due to microorganisms named meticillin-resistant Staphylococcus aureus (MRSA). People that are currently sick in clinic are primarily occurred in by disease with MRSA bacteria. The disease could not be easy to deal with also it may also distribute to others.. A cream is also which includes mupirocin. Its recommended for those who will be with individuals with MRSA infection in contact. From distributing to others it will help to prevent the disease. View individual medication booklet named Mupirocin nasal cream which provides extra information about that planning. ...
http://dexamethasone1mgonline.com/mupirocin-cream-generic-bactroban-for-skin-infections/
Comparative Efficacy of Topical Mupirocin With Ciprofloxacin, Gatifloxacin and Vancomycin in the Treatment of Experimental...Comparative Efficacy of Topical Mupirocin With Ciprofloxacin, Gatifloxacin and Vancomycin in the Treatment of Experimental...
Purpose: : To determine the comparative efficacy of topical mupirocin with vancomycin, gatifloxacin, and ciprofloxacin against high-level ciprofloxacin-resistant MRSA in vitro and in an animal model of keratitis. Methods: : In vitro susceptibility testing by E test was conducted to determine the minimal inhibitory concentration (MICs) for mupirocin 20 mg/ml, linezolid 20 mg/ml, vancomycin 31 mg/ml, ciprofloxacin 3 mg/ml, gatifloxacin 3 mg/ml, quinupristin-dalfopristin (Synercid) 3 mg/ml and moxifloxacin 5 mg/ml against a clinical strain of Staphylococcus aureus known to resistant to ciprofloxacin and methicillin (MRSA). Experimental keratitis was induced via intrastromal inoculation of the ciprofloxacin-resistant and MRSA in a rabbit model. Forty-five rabbits were randomly divided into 5 groups and each group was treated hourly for 12 hours with topical 0.9% balanced salt solution, 0.3% ciprofloxacin hydrochloride, 0.3% gatifloxacin, 2% mupirocin and vancomycin (25 mg/mL). Corneas were excised, ...
http://iovs.arvojournals.org/article.aspx?articleid=2393389
Magiran | Effect of Intranasal Mupirocin in Preventing Post-operative Infection after Open Heart SurgeryMagiran | Effect of Intranasal Mupirocin in Preventing Post-operative Infection after Open Heart Surgery
Background and purposeSurgical site infection is one of the most important complications of cardiac surgery, and in 50% of cases, is caused by Staphylococcus species. This study evaluated the effectiveness of intranasal administration of mupirocin in reducing nasal bacterial colonization, mediastinal, sternal, pulmonary, and skin infections after open-heart surgery.Materials and methodsThis descriptive study investigated the records of patients who developed post-operative infection following open-heart surgery in Sari Fatemeh Zahra Hospital during 2011-2015. Treatments were done in two different periods: first period from 2011 to September 2013 and the second period from October 2013 to March 2015. In second course, intra-nasal administration of mupirocin was done to all patients, as a routine hospital care. Then, the incidence of post-operative infection, type, and site of infection were compared.ResultsFrequency of infection was 78.26% in the group that had recieved mupirocin and 46.29% in the group
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The methicillin-resistant Staphylococcus aureus (MRSA) population in the Hospital Universitario Nuestra Se ora de Candelaria over a 5-year period (1998 to 2002) was marked by shifts in the circulation of pandemic clones. Here, we investigated the emergence of high-level mupirocin resistance (Hi-Mupr). In addition to clonal spread, transfer of ileS2-carrying plasmids played a significant role in the dissemination of Hi-Mupr among pandemic MRSA lineages. Most hospital-acquired methicillin-resistant Staphylococcus aureus (MRSA) isolates are members of five MRSA pandemic lineages or clonal complexes (CCs), namely, CC5, CC8, CC22, CC30, and CC45. Mupirocin constitutes the cornerstone of avoidance of MRSA carriage and ulterior infection, but resistance has emerged, and its spreading is worrisome, with transferable high-level mupirocin resistance (Hi-Mupr) being of clinical significance. Hi-Mupr is associated with an additional isoleucyl-tRNA synthetase that is encoded by the ileS2 gene. The ileS2 gene ...
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ABSTRACT Objectives: The objectives of this study were to determine the susceptibility of Methicillin Resistant Staphylococcus aureus (MRSA) isolates to Mupirocin and other antimicrobial agents and to record the prevalence and distribution of this organism at the University Hospital of the West Indies (UHWI). Methods: MRSA isolates collected between January 1, 2008 and
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This is a Phase 2, open label, multi-center, randomized trial to determine the safety and efficacy of mupirocin in eradicating colonization with Staphylococcus aureus (SA) and preventing the occurrence of invasive and other clinically significant SA infections among critically ill infants in the ICU. Infants hospitalized in an ICU at any one of the 6 participating centers with a positive nasal culture for SA will be eligible to enroll. Infants will be stratified by birth gestational age (, 28 weeks and ,8 weeks of post-natal life or , /= 28 weeks / , 28 weeks and , /=8 weeks of post-natal life) and colonizing strain methicillin-resistant Staphylococcus aureus (MRSA) or methicillin-sensitive Staphylococcus aureus (MSSA) and then randomized 1:1 to receive a 5 day course of mupirocin applied to the nares, umbilicus and perianal (NUP) areas every 8 hours (± 2 hours) vs. no treatment. (Stratification by birth gestational age is performed to minimize bias that could result from a higher risk for ...
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This is a Phase 2, open label, multi-center, randomized trial to determine the safety and efficacy of mupirocin in eradicating colonization with Staphylococcus aureus (SA) and preventing the occurrence of invasive and other clinically significant SA infections among critically ill infants in the ICU. Infants hospitalized in an ICU at any one of the 6 participating centers with a positive nasal culture for SA will be eligible to enroll. Infants will be stratified by birth gestational age (, 28 weeks and ,8 weeks of post-natal life or , /= 28 weeks / , 28 weeks and , /=8 weeks of post-natal life) and colonizing strain methicillin-resistant Staphylococcus aureus (MRSA) or methicillin-sensitive Staphylococcus aureus (MSSA) and then randomized 1:1 to receive a 5 day course of mupirocin applied to the nares, umbilicus and perianal (NUP) areas every 8 hours (± 2 hours) vs. no treatment. (Stratification by birth gestational age is performed to minimize bias that could result from a higher risk for ...
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Prevention of nosocomial Staphylococcus aureus infections after rapid detection and eradication of S. aureus carriage in...Prevention of nosocomial Staphylococcus aureus infections after rapid detection and eradication of S. aureus carriage in...
This study investigated the efficacy of mupirocin nasal ointment + chlorhexidine body soap in the prevention of nosocomial staphylococcal infections. Primary
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The Natural History of Community-Associated Methicillin-Resistant Staphylococcus Aureus (CA-MRSA) Infections and an Evaluation...The Natural History of Community-Associated Methicillin-Resistant Staphylococcus Aureus (CA-MRSA) Infections and an Evaluation...
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Surgical site infections (SSIs) are the most common and expensive healthcare-acquired infection. The objective of this nurse-driven process improvement project was to implement a cost-effective and practical decolonization protocol to improve outcomes for high-risk veteran populations undergoing surgery at a large veterans hospital in the Pacific Northwest. Prior to the implementation, a decolonization protocol was used for cardiac and orthopedic preoperative patients. The process involved screening for methicillin-resistant Staphylococcus aureus (MRSA) colonization via nasal swab preoperatively and treating positive patients with mupirocin ointment to nares BID and chlorhexidine showers for five days prior to surgery. Adherence to the protocol was problematic and SSI rates increased in these populations. New evidence-based practice recommendations published in 2105 described a 50% reduction of SSI with screening for MRSA in the pre-operative clinic, followed by treating each preoperative patient with
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TY - JOUR. T1 - A randomized prospective study of topical antimicrobial agents on skin grafts after thermal injury. AU - Herndon, David. PY - 1990. Y1 - 1990. UR - http://www.scopus.com/inward/record.url?scp=84937174366&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84937174366&partnerID=8YFLogxK. M3 - Article. VL - 86. SP - 1065. JO - Plastic and Reconstructive Surgery. JF - Plastic and Reconstructive Surgery. SN - 0032-1052. IS - 6. ER - ...
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Home Dialysis Central | Gentamycin Ointment For PD Exit Sites Did Not Increase Antibiotic ResistanceHome Dialysis Central | Gentamycin Ointment For PD Exit Sites Did Not Increase Antibiotic Resistance
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https://encompass.eku.edu/honors_theses/245/
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Kidney Patient Guide • View topic - From PD to HDKidney Patient Guide • View topic - From PD to HD
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... acid D06AX02 Chloramphenicol D06AX04 Neomycin D06AX05 Bacitracin D06AX07 Gentamicin D06AX08 Tyrothricin D06AX09 Mupirocin ...
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MometasoneMometasone
Zenhale Mometasone and fusidic acid as Momate-F Mometasone and miconazole as Elica M and Sensicort-F Mometasone and mupirocin ...
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WHO Model List of Essential MedicinesWHO Model List of Essential Medicines
Clopidogrel Alteplaseα Streptokinaseα Simvastatin Miconazole Selenium sulfide Sodium thiosulfate Terbinafine Mupirocin ...
https://en.wikipedia.org/wiki/WHO_Model_List_of_Essential_Medicines
WHO Model List of Essential Medicines for ChildrenWHO Model List of Essential Medicines for Children
Miconazole Terbinafine Mupirocin Potassium permanganate Silver sulfadiazine Betamethasone Calamine Hydrocortisone Benzoyl ...
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List of drugs: Mp-MyList of drugs: Mp-My
111 MPI Krypton 81m Gas Generator MPI Stannous Diphosphonate MS Contin Mucinex Mucomyst Mucosil Multifuge Mupirocin mupirocin ( ...
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Beecham GroupBeecham Group
... mupirocin) Broxil (pheneticillin) Celbenin (meticillin) clavulanic acid Eminase (anistreplase) Engerix-B (hepatitis B vaccine) ...
https://en.wikipedia.org/wiki/Beecham_Group
Fusidic acidFusidic acid
... and mupirocin was found to be the more problematic topical antibiotic for the aforementioned conditions. Some bacteria also ...
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F89F89
... a mupirocin-resistant strain of Staphylococcus aureus Aradu (F89), a 1980 Nigerian frigate DKW F89, a 1950 compact front wheel ...
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Timeline of antibioticsTimeline of antibiotics
... mupirocin 1986 - aztreonam 1986 - cefoperazone/sulbactam 1986 - co-ticarclav (ticarcillin/clavulanic acid) 1987 - ampicillin/ ...
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MMPCMMPC
... involved in biosynthesis of Mupirocin This disambiguation page lists articles associated with the title MMPC. If an internal ...
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Mupirocin - WikipediaMupirocin - Wikipedia
Therefore, it is believed that mupirocin is constructed by a mixed type I and type II PKS system. The mupirocin cluster ... Mupirocin is inactive for most anaerobic bacteria, mycobacteria, mycoplasma, chlamydia, yeast and fungi. Intranasal mupirocin ... Shortly after the clinical use of mupirocin began, strains of Staphylococcus aureus that were resistant to mupirocin emerged, ... in the 9-hydroxy-nonanoic acid portion of mupirocin. The 74 kb mupirocin gene cluster contains six multi-domain enzymes and ...
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Mupirocin: MedlinePlus Drug InformationMupirocin: MedlinePlus Drug Information
Mupirocin: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Mupirocin is for external use only. Do not let mupirocin ointment get into your eyes, nose, or mouth, and do not swallow it. Do ... Mupirocin comes in an ointment that is applied to the skin. Mupirocin usually is applied three times a day for 1 to 2 weeks. ... Before using mupirocin,. *tell your doctor and pharmacist if you are allergic to mupirocin or any other drugs. ...
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Category:Mupirocin - Wikimedia CommonsCategory:Mupirocin - Wikimedia Commons
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Mupirocin Support Group - Drugs.comMupirocin Support Group - Drugs.com
Ask questions and get answers about Mupirocin. Our support group helps people share their own experience. 67 questions, 23 ... Mupirocin Patient Information at Drugs.com. *Mupirocin Information for Consumers. *Mupirocin Information for Healthcare ... Mupirocin - I have MRSA in my nose but cannot afford to go back to the hospital what can I put on it. Posted 3 days ago • 0 ... Mupirocin - Why did the hospital give this to my husband? He had no infection in his nose?. Posted 7 Jul 2017 • 0 answers ...
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Mupirocin | Memorial Sloan Kettering Cancer CenterMupirocin | Memorial Sloan Kettering Cancer Center
No se debe utilizar esta información para decidir si se debe tomar este medicamento o cualquier otro. Solamente el proveedor de atención médica tiene el conocimiento y la capacitación para decidir qué medicamentos son adecuados para un paciente específico. Esta información no recomienda ningún medicamento como seguro, eficaz o aprobado para tratar a ningún paciente o enfermedad. Es solamente un breve resumen de información general sobre este medicamento. NO incluye toda la información sobre los usos, las instrucciones, las advertencias, las precauciones, las interacciones, los efectos secundarios o los riegos posibles que podrían aplicarse a este medicamento. Esta información no constituye asesoramiento médico específico y no reemplaza la información que usted recibe de su proveedor de atención médica. Debe hablar con el proveedor de atención médica para obtener información completa sobre los riesgos y los beneficios de tomar este medicamento.. ...
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Can I use expired unopened mupirocin ointment?Can I use expired unopened mupirocin ointment?
... mupirocin, expiration, expiration date - Answer: Im normally fairly casual about expiration dates with some simple ... ... mupirocin, expiration, expiration date. Details:. I found a tube of unopened mupirocin ointment, but it is a year past the ... Side Effects of Mupirocin (detailed). Search for questions. Still looking for answers? Try searching for what you seek or ask ... Can I use expired unopened mupirocin ointment?. Asked. 2 Oct 2016 by enhale2. Active. 2 Oct 2016. Topics. ...
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Mupirocin (Nasal Route) Side Effects - Mayo ClinicMupirocin (Nasal Route) Side Effects - Mayo Clinic
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:. ...
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Mupirocin | C26H44O9 - PubChemMupirocin | C26H44O9 - PubChem
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Mupirocin Topical: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - WebMDMupirocin Topical: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - WebMD
Find patient medical information for mupirocin topical on WebMD including its uses, side effects and safety, interactions, ... Mupirocin Ointment Common Brand(S): Bactroban Generic Name(S): mupirocin View Free Coupon *Uses ... Who should not take Mupirocin Ointment? * What should I know regarding pregnancy, nursing and administering Mupirocin Ointment ... Before using mupirocin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This ...
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mupirocin topical Reviews and User Ratings: Effectiveness, Ease of Use, and Satisfactionmupirocin topical Reviews and User Ratings: Effectiveness, Ease of Use, and Satisfaction
Find user ratings and reviews for mupirocin topical on WebMD including side effects and drug interactions, medication ... My doctor then prescribed mupirocin to heal the inflamed, raw area. The area is hard and scaly. When I washed it off, scabs ... My doctor then prescribed mupirocin to heal the inflamed, raw area. The area is hard and scaly. When I washed it off, scabs ... Read user comments about the side effects, benefits, and effectiveness of mupirocin topical. ...
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Find the most comprehensive real-world treatment information on Mupirocin topical at PatientsLikeMe. 18 patients with ... bipolar I disorder or psoriasis currently take Mupirocin topical. ... Stopped taking Mupirocin topical Duration. Patients. This item ... Currently taking Mupirocin topical Duration. Patients. This item is relevant to you: 1 - 6 months 1 * 1 ... Why patients stopped taking Mupirocin topical. Multiple reasons could be selected. Reason. Patients. This item is relevant to ...
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Bactroban Cream (Mupirocin Calcium Cream): Side Effects, Interactions, Warning, Dosage & UsesBactroban Cream (Mupirocin Calcium Cream): Side Effects, Interactions, Warning, Dosage & Uses
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Bactroban Nasal (Mupirocin Calcium Ointment): Side Effects, Interactions, Warning, Dosage & UsesBactroban Nasal (Mupirocin Calcium Ointment): Side Effects, Interactions, Warning, Dosage & Uses
Mupirocin Calcium Ointment) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and ... Results of the following studies performed with mupirocin calcium or mupirocin sodium in vitro and in vivo did not indicate a ... BACTROBAN nasal ointment is a white to off-white ointment that contains mupirocin calcium (equivalent to 2% mupirocin free acid ... mupirocin calcium) Nasal Ointment. DESCRIPTION. BACTROBAN (mupirocin calcium) nasal ointment, 2% contains the dihydrate ...
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Mupinova (Mupirocin) Zuventus HealthcareMupinova (Mupirocin) Zuventus Healthcare
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Lithium mupirocin | C26H43LiO9 - PubChemLithium mupirocin | C26H43LiO9 - PubChem
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Drug Shortage Detail: Mupirocin Calcium 2% CreamDrug Shortage Detail: Mupirocin Calcium 2% Cream
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mupirocin | healthdirectmupirocin | healthdirect
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Mupirocin for Staphylococcus aureus Decolonization of Infants in Neonatal Intensive Care Units | American Academy of PediatricsMupirocin for Staphylococcus aureus Decolonization of Infants in Neonatal Intensive Care Units | American Academy of Pediatrics
For mupirocin efficacy, defined as 1 minus the relative risk (ratio of the proportions of subjects not decolonized, mupirocin- ... Colonized infants who met eligibility criteria were randomly assigned to receive 5 days of mupirocin versus no mupirocin to the ... Mupirocin for Staphylococcus aureus Decolonization of Infants in Neonatal Intensive Care Units. Karen L. Kotloff, Debbie-Ann T ... We found that mupirocin was safe and highly efficacious in inducing primary SA decolonization in the NICU, an effect that is ...
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Mupirocin-resistant, methicillin-resistant Staphylococcus aureus: does mupirocin remain effective? - PubMed - NCBIMupirocin-resistant, methicillin-resistant Staphylococcus aureus: does mupirocin remain effective? - PubMed - NCBI
Mupirocin-resistant, methicillin-resistant Staphylococcus aureus: does mupirocin remain effective?. Walker ES1, Vasquez JE, ... To determine the efficacy of mupirocin ointment in reducing nasal colonization with mupirocin-susceptible, methicillin- ... Mupirocin was effective in eradicating MS MRSA, but strains of MR MRSA often persisted after treatment. This appeared to ... MRSA clearance and type turnover were assessed for isolates that were mupirocin-susceptible, low-level (LL) MR MRSA and high- ...
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Is it safe to use Mupirocin in children? | Antibacterial - SharecareIs it safe to use Mupirocin in children? | Antibacterial - Sharecare
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Mupirocin | Springer for Research & DevelopmentMupirocin | Springer for Research & Development
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Randomized controlled trial of topical mupirocin versus mupirocin with sucralfate combination in chronic skin ulcers. - PubMed...Randomized controlled trial of topical mupirocin versus mupirocin with sucralfate combination in chronic skin ulcers. - PubMed...
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MUPIROCIN OINTMENT USP, 2% Drug Information - Medicine OnlineMUPIROCIN OINTMENT USP, 2% Drug Information - Medicine Online
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Staphylococcus26
  • Mupirocin is used as a topical treatment for bacterial skin infections, for example, furuncle, impetigo, open wounds, which are typically due to infection by Staphylococcus aureus or Streptococcus pyogenes. (wikipedia.org)
  • Shortly after the clinical use of mupirocin began, strains of Staphylococcus aureus that were resistant to mupirocin emerged, with nares clearance rates of less than 30% success. (wikipedia.org)
  • Mupirocin-resistant, methicillin-resistant Staphylococcus aureus: does mupirocin remain effective? (nih.gov)
  • To determine the efficacy of mupirocin ointment in reducing nasal colonization with mupirocin-susceptible, methicillin-resistant Staphylococcus aureus (MS MRSA) as well as mupirocin-resistant MRSA (MR MRSA). (nih.gov)
  • Mupirocin has been shown to be active against most strains of Staphylococcus aureus and Streptococcus pyogenes, both in vitro and in clinical studies. (medicineonline.com)
  • Mupirocin is active against most strains of Staphylococcus epidermidis and Staphylococcus saprophyticus. (medicineonline.com)
  • The studies, which entailed five successive assays, showed AP158 to be potent and bactericidal against mupirocin-resistant and mupirocin-susceptible Staphylococcus aureus strains. (infectioncontroltoday.com)
  • Mupirocin is a leading commercially available antibiotic used extensively in hospitals to treat Staphylococcus aureus and Streptococcus pyogenes infections. (infectioncontroltoday.com)
  • Liposomal mupirocin holds promise for systemic treatment of invasive Staphylococcus aureus infections. (bioportfolio.com)
  • Mupirocin Resistance in Staphylococcus aureus: A Systematic Review and Meta-Analysis. (bioportfolio.com)
  • Mupirocin ointment shows in vivo activity against Staphylococcus aureus (including methicillin-resistant strains), S. epidermidis and beta-haemolytic Streptococcus species. (lymphedemapeople.com)
  • This is a Phase 2, open label, multi-center, randomized trial to determine the safety and efficacy of mupirocin in eradicating colonization with Staphylococcus aureus (SA) and preventing the occurrence of invasive and other clinically significant SA infections among critically ill infants in the ICU. (clinicaltrials.gov)
  • 8 weeks of post-natal life) and colonizing strain methicillin-resistant Staphylococcus aureus (MRSA) or methicillin-sensitive Staphylococcus aureus (MSSA) and then randomized 1:1 to receive a 5 day course of mupirocin applied to the nares, umbilicus and perianal (NUP) areas every 8 hours (± 2 hours) vs. no treatment. (clinicaltrials.gov)
  • SAN DIEGO, CA- Use of intranasal mupirocin as a strategy to prevent methicillin-resistant Staphylococcus aureus (MRSA) in the neonatal intensive care unit (NICU) is limited by a 50% recolonization rate in some high-risk neonates, reported Sara M. Wittig, MPH, CIC, from Johns Hopkins Hospital, Baltimore, MD, at IDWeek 2012. (empr.com)
  • Nearly all clinical isolates of Staphylococcus aureus and Staphylococcus epidermidis, including multiply resistant strains, were susceptible (mupirocin MIC, less than or equal to 0.5 microgram/ml). (asm.org)
  • The objectives of this study were to determine the susceptibility of Methicillin Resistant Staphylococcus aureus (MRSA) isolates to Mupirocin and other antimicrobial agents and to record the prevalence and distribution of this organism at the University Hospital of the West Indies (UHWI). (uwi.edu)
  • Seven per cent of Staphylococcus aureus isolates were resistant to methicillin (MRSA) and of these, 30% and 24% showed low level and high level resistance to mupirocin, respectively. (uwi.edu)
  • Can mupirocin prevent methicillin-resistant Staphylococcus aureus infections? (biomedcentral.com)
  • In a retrospective study, Dr Muller and colleagues have assessed the efficacy of mupirocin nasal ointment alongside hygienic measures in methicillin-resistant Staphylococcus aureus (MRSA)-positive patients admitted to the intensive care unit (ICU). (biomedcentral.com)
  • The emergence and prevalence of high - level mupirocin - resistant, methicillin - resistant Staphylococcus aureus (MuH MRSA) is challenging the eradication of MRSA nasal carriage and the treatment of skin and soft tissue infections. (plos.org)
  • Mupirocin (Nasal) is an antibiotic that is used to kill a group of bacteria found in nasal passages and for the elimination of nasal colonization with methicillin-resistant Staphylococcus aureus. (practo.com)
  • VisualAbstract: Mupirocin for Staphylococcus aureus Decolonization of Infants in Neonatal Intensive. (2minutemedicine.com)
  • Mupirocin is a topical antibiotic used to treat impetigo, which is a bacterial skin infection caused by the bacteria Staphylococcus aureus or Streptococcus pyogenes. (icliniq.com)
  • Certain bacterial skin infections -- most notably methicillin-resistant Staphylococcus aureus -- can be treated with mupirocin. (emedtv.com)
  • Mupirocin is a drug used for the treatment of impetigo and infections of the skin caused by Staphylococcus aureus , beta-hemolytic streptococcus, or Streptococcus pyogenes . (purgweb.com)
  • Intranasal Mupirocin to Eliminate Carriage of Staphylococcus Aureus in HIV Infection. (springer.com)
Nasal ointment7
  • How do you get the top off the vial of mupirocin nasal ointment? (drugs.com)
  • BACTROBAN (mupirocin calcium) nasal ointment, 2% contains the dihydrate crystalline calcium hemi-salt of the antibacterial drug, mupirocin. (rxlist.com)
  • BACTROBAN nasal ointment is a white to off-white ointment that contains 2.15% w/w mupirocin calcium (equivalent to 2% mupirocin free acid) in a soft white ointment base. (rxlist.com)
  • Results from recent clinical trials that studied the efficacy of mupirocin nasal ointment in preventing methicillin-susceptible S. aureus (MSSA) infections can be extrapolated to MRSA infections. (biomedcentral.com)
  • But can mupirocin nasal ointment prevent MRSA infections in ICUs? (biomedcentral.com)
  • Buy Bactroban Nasal Ointment (Mupirocin) online at the guaranteed lowest price.Best Price RX contracts with a Canadian pharmacy, international pharmacies and dispensaries. (bestpricerx.com)
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Aureus12
  • Intranasal mupirocin before surgery is effective for prevention of post-operative wound infection with Staphylcoccus aureus and preventative intranasal or catheter-site treatment is effective for reducing the risk of catheter site infection in persons treated with chronic peritoneal dialysis. (wikipedia.org)
  • Two distinct populations of mupirocin-resistant S. aureus were isolated. (wikipedia.org)
  • Mupirocin is used in hospitals to prevent infections in surgical patients undergoing general, gynecologic, cardiothoracic and neurosurgical operations, as well as in patients undergoing peritoneal dialysis and in intensive care units to decrease the incidence of disease caused by S. aureus and S. pyogenes. (infectioncontroltoday.com)
  • Mupirocin has been increasingly used for treatment of S. aureus (MSSA) and methicillin resistant S. aureus (MRSA) infections. (bioportfolio.com)
  • The aim of the present study, was to determine the precise prevalence of Mupirocin Resistant S. aureus (MuRSA), Mupirocin Resistant MRSA (MuRMRSA), High Level MuRSA (HLMuRSA) and High Level MuRMRSA (HLMuRMR. (bioportfolio.com)
  • In comparison with non-ICU patients, critically ill patients admitted to ICUs may receive more benefit from mupirocin, even when moderately efficacious, because the rate of S. aureus infections in ICU patients is much higher. (biomedcentral.com)
  • Plasmid profile of transconjugants derived from the methicillin/mupirocin resistant S. aureus (strain A15) from South Africa . (biomedcentral.com)
  • . S. aureus 8325-4 was exposed to sub-inhibitory concentrations of mupirocin. (microbiologyresearch.org)
  • Transcriptome profiles showed that global transcriptional alterations were similar to those for S. aureus after treatment with lethal concentrations of mupirocin, including the repression of genes involved in transcription, translation and replication machineries. (microbiologyresearch.org)
  • Conversely, mupirocin is more favorable when the institutional incidence and prevalence rates of S aureus infections are high. (infectiousdiseaseadvisor.com)
  • Extensive use of mupirocin has resulted in the emergence of resistant strains of S. aureus in the United Kingdom. (asmscience.org)
  • Mupirocin eradicates methicillin-resistant strains of S. aureus colonizing the skin and produces an improvement in the healing of skin wounds. (asmscience.org)
Active ingredient3
Infections24
  • Mupirocin, an antibiotic, is used to treat impetigo as well as other skin infections caused by bacteria. (medlineplus.gov)
  • Mupirocin, sold under the brand name Bactroban among others, is a topical antibiotic useful against superficial skin infections such as impetigo or folliculitis. (wikipedia.org)
  • Mupirocin is used to treat certain skin infections (such as impetigo ). (webmd.com)
  • Mupirocin (Bactroban, Centany) is a topical antibiotic cream or ointment used to treat minor bacterial skin infections such as impetigo. (sharecare.com)
  • Mupirocin is a promising broad-spectrum antibiotic that is effective in treating MRSA infections. (bioportfolio.com)
  • This study evaluated the effectiveness of intranasal administration of mupirocin in reducing nasal bacterial colonization, mediastinal, sternal, pulmonary, and skin infections after open-heart surgery. (magiran.com)
  • Intra-nasal administration of mupirocin could prevent cutaneous infections after cardiac surgery and also reduce hospital length of stay. (magiran.com)
  • Currently, there is limited longitudinal data available on the effectiveness of intranasal mupirocin to eradicate colonization and reduce the morbidity and mortality caused by MRSA infections. (empr.com)
  • A total of 16% of patients treated with intranasal mupirocin still developed MRSA, and 42% of all infections preceded identification of intranasal colonization. (empr.com)
  • They noted that further randomized studies are needed determine efficacy of intranasal mupirocin and to identify other adjuvant strategies to prevent MRSA infections in neonates. (empr.com)
  • Mupirocin nasal is used to prevent severe staph infections in patients and healthcare workers who may be at risk of infection during an outbreak within a hospital or other healthcare setting. (canadapharmacy.com)
  • Their findings, which suggest that intranasal mupirocin can prevent ICU-related MRSA infections, need confirmation in a well-designed clinical trial. (biomedcentral.com)
  • AIM: Mupirocin is widely used for the topical treatment of infections. (minervamedica.it)
  • Mupirocin is a very effective topical antibiotic used to treat staphylococcal skin and soft tissue infections and eliminate MRSA from colonized nasal passages. (plos.org)
  • Thus the high-level mupirocin resistance MRSA (MuH MRSA) may spread widely, and causes a range of infections. (plos.org)
  • Mupirocin is an antibiotic ointment given to prevent infections in open wounds and promote healing. (healthcaremagic.com)
  • Topical gentamicin is superior to mupirocin for prophylaxis against gram-negative bacterial infections among patients on peritoneal dialysis (PD), according to a new systematic review and meta-analysis. (infectiousdiseaseadvisor.com)
  • The investigators assessed the risk of exit-site infections in a meta-analysis of 7 studies involving 458 patients treated with mupirocin and 448 treated with gentamicin. (infectiousdiseaseadvisor.com)
  • Gram-negative exit-site infections, however, occurred at a higher rate among mupirocin patients. (infectiousdiseaseadvisor.com)
  • Comparison of topical mupirocin and gentamicin in the prevention of peritoneal dialysis-related infections: A systematic review and meta-analysis [published online March 16, 2017]. (infectiousdiseaseadvisor.com)
  • Bactroban (Mupirocin) is an antibiotic ointment that is effective in treating impetigo, and other skin infections that bacteria causes. (4nrx.org)
  • Mupirocin also may be used for secondary infections as determined by your doctor. (purgweb.com)
  • Staphban Ointment (Mupirocin) is an antimicrobial used to treat bacterial infections in dogs. (4nrx.md)
  • A wide range of bacterial skin infections can be treated with mupirocin ( Bactroban ® ), which is a common antibiotic. (emedtv.com)
Cream16
  • BACTROBAN (mupirocin calcium) cream, 2% contains the dihydrate crystalline calcium hemi- salt of the RNA synthetase inhibitor antibacterial, mupirocin. (rxlist.com)
  • BACTROBAN cream is a white cream that contains 2.15% w/w mupirocin calcium (equivalent to 2% mupirocin free acid) in an oil- and water-based emulsion. (rxlist.com)
  • Glenmark has mupirocin cream available. (ashp.org)
  • Cream: 2.15% w/w mupirocin calcium (equivalent to 2% mupirocin free acid) in 15-gram and 30-gram tubes. (gsksource.com)
  • Known hypersensitivity to mupirocin or any of the excipients of BACTROBAN cream. (gsksource.com)
  • Group 1 (28 patients) were treated with topical 2% fusidic acid plus 0.1% betamethasone cream, and group 2 (18 patients) with topical 2% mupirocin and 0.1% betamethasone cream. (nih.gov)
  • mupirocin 2 cream uses, there were numerous rales. (fantasycon2012.org)
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  • Mupirocin Cream is used. (ipadmania.de)
  • I suggest you try applying T-Bact cream (Mupirocin) twice daily. (icliniq.com)
  • Mupirocin Cream is a medicine that is used for the treatment of Wounds, Skin Infection Caused by Bacteria, Impetigo and other conditions. (aviencepharma.com)
  • Mupirocin Cream works by stopping the growth of certain bacteria by blocking the protein synthesis. (aviencepharma.com)
  • The following is a list of possible side effects that may occur from all constituting ingredients of Mupirocin Cream. (aviencepharma.com)
  • Mupirocin topical cream was approved by the FDA in December, 1987. (purgweb.com)
Dosage5
  • One of the dosage forms available for Amikacin/Mupirocin is Polox-A-Gel Otic. (wedgewoodpharmacy.com)
  • Amikacin/Mupirocin is also available in these dosage forms. (wedgewoodpharmacy.com)
  • One of the dosage forms available for Amikacin/Mupirocin is Topical Spray. (wedgewoodpharmacy.com)
  • The dosage form available for Amikacin/Mupirocin/Silver Sulfadiazine/Triamcinalone/Pracasil is Polox-A-Gel Otic. (wedgewoodpetrx.com)
  • Detailed information related to Mupirocin Cream's uses, composition, dosage, side effects and reviews is listed below. (aviencepharma.com)
Unopened mupirocin ointment2
  • Can I use expired unopened mupirocin ointment? (drugs.com)
  • I found a tube of unopened mupirocin ointment, but it is a year past the expiration date. (drugs.com)
MRSA16
  • Prospective evaluation in which patients colonized with MRSA were treated twice daily with 2% topical mupirocin ointment for 5 days. (nih.gov)
  • MRSA clearance and type turnover were assessed for isolates that were mupirocin-susceptible, low-level (LL) MR MRSA and high-level (HL) MR MRSA. (nih.gov)
  • Mupirocin was effective in eradicating MS MRSA, but strains of MR MRSA often persisted after treatment. (nih.gov)
  • MR MRSA is now more prevalent and it is appropriate to sample MRSA populations for mupirocin susceptibility prior to incorporating mupirocin into infection control programs. (nih.gov)
  • Mupirocin is an antibiotic with a unique mode of action that is active against MRSA, but its clinical use is restricted to topical administration because of its limited plasma stability and rapid degradation to inactive metabolites. (bioportfolio.com)
  • Infants with a culture growing MRSA were treated with intranasal mupirocin, and some infants received 2% chlorhexidine gluconate baths. (empr.com)
  • Of the 66 MRSA colonized infants, 37 (56%) received intranasal mupirocin. (empr.com)
  • Half of the neonates who received intranasal mupirocin and remained in the NICU for ≥21 days became recolonized with MRSA. (empr.com)
  • Using pulsed-field gel electrophoresis, we confirmed that the genotypes of MRSA that colonized the pharynx before and after the use of mupirocin were identical. (asm.org)
  • Our data suggested that low concentrations of the drug in the pharynx after intranasal application of mupirocin ointment might explain the selection of mupirocin resistance in MRSA. (asm.org)
  • MRSA isolates collected between January 1, 2008 and December 31, 2008, were tested for low and high level resistance to Mupirocin. (uwi.edu)
  • Laboratory records for all patients from whom MRSA was recovered were reviewed and data on type and source of isolates, clinical diagnosis, history of previous hospitalization and use of mupirocin were extracted. (uwi.edu)
  • Resistance of MRSA to mupirocin appears to be an emerging problem at the UHWI and must be monitored carefully. (uwi.edu)
  • Muller and colleagues performed a retrospective study in which they compared a 2-year MRSA control program with intranasal application of mupirocin, with a 2-year program in which mupirocin was not used. (biomedcentral.com)
  • Liu Q, Han L, Li B, Sun J, Ni Y (2012) Virulence Characteristic and MLST- agr Genetic Background of High-Level Mupirocin-Resistant, MRSA Isolates from Shanghai and Wenzhou, China. (plos.org)
  • If high-level mupirocin resistance could not be controled, a highly effective means of decolonization of MRSA may be lost. (plos.org)
Methicillin1
  • AP158, with its demonstrated ability to kill bacteria resistant to mupirocin, methicillin and vancomycin, provides a new weapon in the resistance battle. (infectioncontroltoday.com)
Strains5
  • Mupirocin is not a viable antibiotic against MuH strains. (wikipedia.org)
  • Most strains of Cutibacterium acnes, a causative agent in the skin disease acne vulgaris, are naturally resistant to mupirocin. (wikipedia.org)
  • The Effect of Subinhibitory Concentrations of -Anethole on Antibacterial and Antibiofilm Activity of Mupirocin Against Mupirocin-Resistant Strains. (bioportfolio.com)
  • The aim of this study was to evaluate the effect of subinhibitory concentrations of -anethole on antibacterial and antibiofilm properties of mupirocin against mupirocin-resistant strains. (bioportfolio.com)
  • Since 1985, when mupirocin was introduced into clinical practice, two types of resistant strains have been described: those for which the MICs are between 8 and 256 µg/ml and those for which the MICs are 512 µg/ml. (asmscience.org)
Activity of mupirocin3
  • Following parameters were examined: isolates susceptibility to antibiotics, minimum inhibitory concentration (MIC) of -anethole, antibacterial activity of mupirocin/-anethole combination, detection of gene, genotypic relativity of isolates using pulsed-field gel electrophoresis method, and the influence of mupirocin/-an. (bioportfolio.com)
  • Antibacterial activity of mupirocin (pseudomonic acid), a new antibiotic for topical use. (asm.org)
  • The activity of mupirocin was not greatly influenced by inoculum size but was significantly enhanced in acid medium. (asm.org)
Application of mupirocin1
  • Local application of mupirocin yields in situ concentrations of 20,000 mg/kg. (asmscience.org)
Administration of mupirocin2
  • In a study conducted in seven healthy adult male subjects, the elimination half-life after intravenous administration of mupirocin was 20 to 40 minutes for mupirocin and 30 to 80 minutes for monic acid. (medicineonline.com)
  • In second course, intra-nasal administration of mupirocin was done to all patients, as a routine hospital care. (magiran.com)
Centany2
  • Common Name: Bactroban Ointment, Centany Ointment Strength: Mupirocin 2.0% w/w Description: Mupirocin is an antibiotic. (europages.co.uk)
  • The generic ingredient in CENTANY is mupirocin . (drugpatentwatch.com)
Pharmacy3
  • 29498 persone hanno già recensito Chemist Direct - UK's Online Pharmacy.4014 mupirocin over the counter . (aytosanlorenzo.es)
  • The TRICARE Pharmacy Program, administered by Express Scripts, is designed to mupirocin over the counter. (aytosanlorenzo.es)
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Antibiotics4
  • The mechanism of action of mupirocin differs from other clinical antibiotics, rendering cross-resistance to other antibiotics unlikely. (wikipedia.org)
  • Mupirocin belongs to the class of medications called topical antibiotics . (canada.com)
  • There was no cross-resistance between mupirocin and clinically available antibiotics, and the selection of resistant variants in vitro occurred at a low frequency. (asm.org)
  • New antibiotics are needed to decolonize the nose because bacterial resistance to mupirocin is rising, and so it will become less effective. (ipadmania.de)
Efficacy2
  • Clinical efficacy of dialkylcarbamoylchloride-coated cotton acetate dressing versus combination of normal saline dressing and 2% mupirocin ointment in infected wounds of epidermolysis bullosa. (bioportfolio.com)
  • This study aimed to assess the clinical efficacy of DACC-coated cotton acetate dressing compared to combination of normal saline dressing and 2% mupirocin ointment. (bioportfolio.com)
Isolates1
  • Isolates underwent mupirocin-susceptibility testing and DNA typing. (nih.gov)
Molecular formula of mupirocin1
  • The molecular formula of mupirocin is C 26 H 44 O 9 and the molecular weight is 500.63. (medicineonline.com)
Impetigo1
  • Mupirocin(Bactroban) generic Supirocin B is an antibiotic, prescribed for impetigo. (medindia.net)
Polox-A-Gel Otic2
  • 1 strength combination of Amikacin/Mupirocin Polox-A-Gel Otic is available. (wedgewoodpharmacy.com)
  • 2 strength combinations of Amikacin/Mupirocin/Silver Sulfadiazine/Triamcinalone/Pracasil Polox-A-Gel Otic are available. (wedgewoodpetrx.com)
Resistant5
  • GAITHERSBURG, Md. -- Antex Pharma Inc., a wholly owned subsidiary of Antex Biologics Inc., announces that AP158, its lead antibiotic compound, killed mupirocin-resistant bacteria in recently completed in vitro studies. (infectioncontroltoday.com)
  • Recent independent analyses, including the Sentry Anti-microbial Surveillance Program sponsored by the University of Iowa and Tufts University, have documented significant increases in the frequency of mupirocin-resistant bacteria, categorizing the resistance as high-level (those with an entirely new binding enzyme) and low-level (those with a modified binding enzyme). (infectioncontroltoday.com)
  • Antex's studies were performed using mupirocin-resistant bacteria showing both high-level and low-level resistance. (infectioncontroltoday.com)
  • Mupirocin shows little risk of selection of resistant bacteria if used as prescribed. (lymphedemapeople.com)
  • Lane 2 - TransCad (resistant to mupirocin and cadmium). (biomedcentral.com)
Synthetase4
  • Mupirocin inhibits bacterial protein synthesis by reversibly and specifically binding to bacterial isoleucyl transfer-RNA synthetase. (medicineonline.com)
  • However, when mupirocin resistance does occur, it appears to result from the production of a modified isoleucyl-tRNA synthetase. (medicineonline.com)
  • Mupirocin is an antibiotic produced through fermentation of Pseudomonas fluorescens and inhibits bacterial protein synthesis by binding to bacterial isoleucyl t-RNA synthetase. (lymphedemapeople.com)
  • Unlike most other penicillin that act on either bacterial DNA or the walls of bacteria, mupirocin blocks the activity of an incentive called isoleucyl-tRNA synthetase within the bacteria. (purgweb.com)
Drugs3
  • tell your doctor and pharmacist if you are allergic to mupirocin or any other drugs. (medlineplus.gov)
  • You can also find out about relevant Mupirocin Calcium Mupirocin Calcium Vehicle Secondarily Infected Traumatic Drugs and Medications on this site too. (bioportfolio.com)
  • Cialis works faster than other ED drugs and mupirocin over the counter . (aytosanlorenzo.es)
Allergic2
  • Do not use this medication if you are allergic to mupirocin or any ingredients of the medication. (canada.com)
  • Do not use it if you had an allergic reaction to mupirocin. (allinahealth.org)
Uses of Mupirocin1
Allergy to mupirocin2
  • Severe contact allergy to mupirocin in a polysensitized patient. (springer.com)
  • This medicine is not recommended for use in patients with a known allergy to mupirocin or any other inactive ingredients present in the formulation. (practo.com)
Concentrations of mupirocin2
  • Low concentrations of mupirocin were present in the pharynx in all cases 10 min to 3 days after intranasal application. (asm.org)
  • Sub-lethal concentrations of mupirocin induce the stringent response, but cells adapt and resume growth once ppGpp levels decrease. (microbiologyresearch.org)
Antibiotic ointment1
  • Can I use mupirocin ointment and triple antibiotic ointment? (drugs.com)
Polyethylene glycol4
  • kidney disease (if you are using a brand of mupirocin that contains polyethylene glycol). (webmd.com)
  • Each gram of Mupirocin Ointment USP, 2% contains 20 mg mupirocin in a bland water miscible ointment base (polyethylene glycol ointment, N.F.) consisting of polyethylene glycol 400 and polyethylene glycol 3350. (medicineonline.com)
  • In common with other polyethylene glycol-based ointments, Mupirocin Ointment USP, 2% should not be used in conditions where absorption of large quantities of polyethylene glycol is possible, especially if there is evidence of moderate or severe renal impairment. (medicineonline.com)
  • Mupirocin is not recommended for use on the skin in serious burns because more of the inactive ingredient used for the ointment, polyethylene glycol (Miralax), may be absorbed and can damage the kidneys. (purgweb.com)
Antimicrobial agents1
  • Due to this unique mode of action, mupirocin demonstrates no in vitro cross-resistance with other classes of antimicrobial agents. (medicineonline.com)
Bacteria4
  • Este medicamento se utiliza para tratar cierta bacteria que generalmente se encuentra en las vías nasales y así evitar que la misma se propague hacia otras vías. (mskcc.org)
  • MUPIROCIN OINTMENT USES AND OTHER INFORMATION Mupirocin is an antibiotic that keeps bacteria from developing on your skin.This Ointment (for use on the skin) is. (lostvirtualtour.com)
  • Mupirocin is an antibiotic that treats or prevents infection that is caused by bacteria. (canadapharmacy.com)
  • Mupirocin (pseudomonic acid A), an antibiotic produced by Pseudomonas fluorescens, showed a high level of activity against staphylococci and streptococci and against certain gram-negative bacteria, including Haemophilus influenzae and Neisseria gonorrhoeae, but was much less active against most gram-negative bacilli an anaerobes. (asm.org)
Pseudomonic2
  • Mupirocin is a mixture of several pseudomonic acids, with pseudomonic acid A (PA-A) constituting greater than 90% of the mixture. (wikipedia.org)
  • Also present in mupirocin are pseudomonic acid B with an additional hydroxyl group at C8, pseudomonic acid C with a double bond between C10 and C11, instead of the epoxide of PA-A, and pseudomonic acid D with a double bond at C4` and C5` in the 9-hydroxy-nonanoic acid portion of mupirocin. (wikipedia.org)
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Necessary mupirocin2
  • The cesarean thiis and lants would be there fur grave, on necessary mupirocin over the counter spain being made to the public pulp-mill dams. (meditationiseasy.com)
  • Now let us consider the mechanics involved when the nose is occluded from any cause, and it becomes necessary mupirocin to open and use the mouth for breathing. (riseaustin.org)
Side effects10
  • Mupirocin may cause side effects. (medlineplus.gov)
  • Read user comments about the side effects, benefits, and effectiveness of mupirocin topical. (webmd.com)
  • What are the possible side effects of mupirocin nasal (Bactroban)? (rxlist.com)
  • The skin attachment is easily recog, mupirocin ointment 2 percent side effects, nent danger of respiratory failure. (fantasycon2012.org)
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  • Just like any medicine, mupirocin can cause side effects. (emedtv.com)
  • The specific side effects depend on the particular form of mupirocin used. (emedtv.com)
  • Click Side Effects of Mupirocin to learn more, including potentially serious side effects you should report immediately to your healthcare provider. (emedtv.com)
  • Click Mupirocin to learn more about what this drug is used for, when and how to take it, additional side effects to be aware of, and general dosing guidelines. (emedtv.com)
Intravenous or oral2
  • Following intravenous or oral adminstration, mupirocin is rapidly metabolized. (medicineonline.com)
  • Following intravenous or oral administration, mupirocin is rapidly metabolised to the inactive monic acid. (lymphedemapeople.com)
Infection4
  • If you still have symptoms of infection after you finish the mupirocin, call your doctor. (medlineplus.gov)
  • If a reaction suggesting sensitivity or chemical irritation should occur with the use of Mupirocin Ointment USP, 2%, treatment should be discontinued and appropriate alternative therapy for the infection instituted. (medicineonline.com)
  • Frequency of infection was 78.26% in the group that had recieved mupirocin and 46.29% in the group that had not received mupirocin. (magiran.com)
  • The rate of surgical site infection in the group that had received mupirocin was 21.74% and in the group without mupirocin it was 53.71% (P= 0.000). (magiran.com)
Medications1
  • Mupirocin is in the carboxylic acid class of medications. (wikipedia.org)
Presence of human serum2
  • Mupirocin was highly bound (95% bound) to the protein of human serum, and activity was reduced 10- to 20-fold in the presence of human serum. (asm.org)
  • As mupirocin is highly serum protein bound, the in vitro activity is reduced in the presence of human serum. (asmscience.org)
Bactericidal at concentrations1
  • Mupirocin is bactericidal at concentrations achieved by topical administration. (medicineonline.com)
Patients5
  • Ninety-six patients were recruited in total, and the modified intention-to-treat analysis dataset included 44 participants treated with mupirocin 2% and 46 treated with combined mupirocin 2% and sucralfate 7% ointment. (nih.gov)
  • We measured the delivery of mupirocin to the pharynx in three normal volunteers and two patients. (asm.org)
  • Patients were divided into two groups for the postoperative management: the first group was treated with daily applications of mupirocin 2% ointment and the second one with daily applications of gentamicin 0.1% ointment. (minervamedica.it)
  • The investigators found no difference in the gram-positive and gram-negative peritonitis rate based on an analysis of 6 studies involving 397 mupirocin and 388 gentamicin patients. (infectiousdiseaseadvisor.com)
  • Patients using Bactroban (Mupirocin) ointment should apply it directly to the skin. (4nrx.org)
Prescription1
Ointment contains2
  • Each gram of ointment contains mupirocin 20 mg (2%) in a bland water-soluble ointment base. (canada.com)
  • The ointment contains 2% mupirocin. (4nrx.md)
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