Mumps Vaccine
Mumps
Mumps virus
Vaccines
Vaccines, Inactivated
Mumps and mumps vaccine: a global review. (1/146)
Mumps is an acute infectious disease caused by a paramyxovirus. Although the disease is usually mild, up to 10% of patients can develop aseptic meningitis; a less common but more serious complication is encephalitis, which can result in death or disability. Permanent deafness, orchitis, and pancreatitis are other untoward effects of mumps. Based on data reported to WHO up to April 1998, mumps vaccine is routinely used by national immunization programmes in 82 countries/areas: 23 (92%) of 25 developed countries, 19 (86%) of 22 countries with economies in transition (mainly the Newly Independent States of the former Soviet Union), and 40 (24%) of 168 developing countries. Countries that have achieved high coverage have shown a rapid decline in mumps morbidity. Furthermore, in many of these countries, mumps-associated encephalitis and deafness have nearly vanished. This review considers the disease burden due to mumps; summarizes studies on the immunogenicity, efficacy, and safety of different strains of mumps vaccine; and highlights lessons learned about implementing mumps immunization in different countries. Countries already using mumps vaccine should monitor immunization coverage and establish routine mumps surveillance with investigation of outbreaks. Where mumps is targeted for elimination, countries need to add a second dose of mumps vaccine for children, keeping in mind that the disease may still occur in susceptible adults. (+info)Evidence of avian leukosis virus subgroup E and endogenous avian virus in measles and mumps vaccines derived from chicken cells: investigation of transmission to vaccine recipients. (2/146)
Reverse transcriptase (RT) activity has been detected recently in all chicken cell-derived measles and mumps vaccines. A study of a vaccine manufactured in Europe indicated that the RT is associated with particles containing endogenous avian retrovirus (EAV-0) RNA and originates from the chicken embryonic fibroblasts (CEF) used as a substrate for propagation of the vaccine. We investigated the origin of RT in measles and mumps vaccines from a U.S. manufacturer and confirm the presence of RT and EAV RNA. Additionally, we provide new evidence for the presence of avian leukosis virus (ALV) in both CEF supernatants and vaccines. ALV pol sequences were first identified in particle-associated RNA by amplification with degenerate retroviral pol primers. ALV RNA sequences from both the gag and env regions were also detected. Analysis of hypervariable region 2 of env revealed a subgroup E sequence, an endogenous-type ALV. Both CEF- and vaccine-derived RT activity could be blocked by antibodies to ALV RT. Release of ALV-like virus particles from uninoculated CEF was also documented by electron microscopy. Nonetheless, infectivity studies on susceptible 15B1 chicken cells gave no evidence of infectious ALV, which is consistent with the phenotypes of the ev loci identified in the CEF. PCR analysis of ALV and EAV proviral sequences in peripheral blood mononuclear cells from 33 children after measles and mumps vaccination yielded negative results. Our data indicate that the sources of RT activity in all RT-positive measles and mumps vaccines may not be similar and depend on the particular endogenous retroviral loci present in the chicken cell substrate used. The present data do not support transmission of either ALV or EAV to recipients of the U.S.-made vaccine and provide reassurance for current immunization policies. (+info)The mumps virus neurovirulence safety test in Rhesus monkeys: a comparison of mumps virus strains. (3/146)
Wild type mumps viruses are highly neurotropic and a frequent cause of aseptic meningitis in unvaccinated humans. To test whether attenuated mumps viruses used in the manufacture of mumps vaccines have neurovirulent properties, a monkey neurovirulence safety test (MNVT) is performed. However, results with several mumps virus MNVTs have raised questions as to whether the test can reliably discriminate neurovirulent from nonneurovirulent mumps virus strains. Here, various mumps virus strains representing a wide range of neuropathogenicity were tested in a standardized MNVT. A trend of higher neurovirulence scores was observed in monkeys inoculated with wild type mumps virus versus vaccine strains, although differences were not statistically significant. Results indicated the need for further examination and refinement of the MNVT or for development of alternative MNVTs. (+info)Infant vaccinations and risk of childhood acute lymphoblastic leukaemia in the USA. (4/146)
Previous studies have suggested that infant vaccinations may reduce the risk of subsequent childhood leukaemia. Vaccination histories were compared in 439 children (ages 0-14) diagnosed with acute lymphoblastic leukaemia (ALL) in nine Midwestern and Mid-Atlantic states (USA) between 1 January 1989 and 30 June 1993 and 439 controls selected by random-digit dialing and individually matched to cases on age, race and telephone exchange. Among matched pairs, similar proportions of cases and controls had received at least one dose of oral poliovirus (98%), diphtheria-tetanus-pertussis (97%), and measles-mumps-rubella (90%) vaccines. Only 47% of cases and 53% of controls had received any Haemophilus influenzae type b (Hib) vaccine (relative risk (RR) = 0.73; 95% confidence interval (CI) 0.50-1.06). Although similar proportions of cases (12%) and controls (11%) received the polysaccharide Hib vaccine (RR = 1.13; 95% CI 0.64-1.98), more controls (41%) than cases (35%) received the conjugate Hib vaccine (RR = 0.57; 95% CI 0.36-0.89). Although we found no relationship between most infant vaccinations and subsequent risk of childhood ALL, our findings suggest that infants receiving the conjugate Hib vaccine may be at reduced risk of subsequent childhood acute lymphoblastic leukemia. Further studies are needed to confirm this association and, if confirmed, to elucidate the underlying mechanism. (+info)Opportunistic immunisation in hospital. (5/146)
AIM: To assess the potential for administering catch up and scheduled immunisations during hospital admission. METHODS: Immunisation status according to the child's principal carer was checked against official records for 1000 consecutively admitted preschool age children. Junior doctors were instructed to offer appropriate vaccination before discharge, and consultants were asked to reinforce this proactive policy on ward rounds. RESULTS: Excluding those children who were not fully immunised against pertussis through parental choice, 142 children (14.2%) had missed an age appropriate immunisation and 41 were due a scheduled immunisation. None had a valid contraindication. Only 43 children were offered vaccination on the ward but uptake was 65% in this group. CONCLUSIONS: Admission to hospital provides opportunities for catch up and routine immunisations and can contribute to the health care of an often disadvantaged group of children. These opportunities are frequently missed. Junior doctors must be encouraged to see opportunistic immunisation as an important part of their routine work. (+info)Decay of passively acquired maternal antibodies against measles, mumps, and rubella viruses. (6/146)
The decay of maternally derived antibodies to measles, mumps, and rubella viruses in Swiss infants was studied in order to determine the optimal time for vaccination. A total of 500 serum or plasma samples from infants up to 2 years of age were tested by enzyme-linked immunosorbent assay and fluorescent-antibody testing. The decline of antibody prevalence was slowest against the measles virus. By 9 to 12 months of age, only 5 of 58 (8.6%; 95% CI, 2.9 to 19.0) infants were antibody positive for the measles virus, and only 2 had levels above 200 mIU/ml. Mumps and rubella virus antibody seropositivity was lowest at 9 to 12 months of age with 3 of 58 (5. 2%; 95% CI, 1.1 to 14.4) infants and at 12 to 15 months with 1 of 48 (2.1%; 95% CI, 0.1 to 11.1) infants, respectively. Concentrations of passively acquired antibodies decreased rapidly within the first 6 months of life. We observed no significant differences in antibody prevalence or concentration according to gender in any age group. In conclusion, MMR vaccination at 12 instead of 15 months of age could reduce the pool of susceptible subjects in infancy and support the efforts to eliminate these infections, particularly in combination with a second vaccine dose before school entry. (+info)Kawasaki disease: a maturational defect in immune responsiveness. (7/146)
Kawasaki disease (KD), an acute febrile disease in children of unknown etiology, is characterized by a vasculitis that may result in coronary artery aneurysms (CAAs). In new patients with KD, a selective and prolonged T cell unresponsiveness to activation via the T cell antigen receptor CD3 was observed, whereas proliferation to other stimuli was intact. This "split T cell anergy" delineated KD from other pediatric infections and autoimmune diseases and correlated with CAA formation (P<.001). A transient immune dysfunction was also suggested by an incomplete responsiveness to measles-mumps-rubella (MMR) vaccination in patients with KD versus controls (P<.0001; odds ratio, 15.6; 95% confidence interval, 4.8-51.1), which was overcome by revaccination(s). The reduced responsiveness to MMR in patients with KD suggests a subtle and predetermining immune dysfunction. An inherent immaturity to clear certain antigens may be an important cause that precipitates KD and the immune dysregulation during acute disease. (+info)Infection with wild-type mumps virus in army recruits temporally associated with MMR vaccine. (8/146)
Four cases of mumps were reported among 180 army recruits who had received MMR vaccine 16 days earlier. Mumps serology, salivary mumps IgM and PCR tests for the SH gene were performed on the 4 cases and on 5 control recruits who remained well. PCR products were sequenced and the sequences compared to those of wild type and vaccine strains of mumps. Further salivary mumps IgM tests were performed on the remaining 171 recruits. Mumps infection was confirmed in the 4 cases but not in the 5 controls. The controls had serological evidence of prior immunity. The SH gene sequence found in the 4 cases was wild type. Saliva tests identified 2 additional recruits with mumps IgM, one of whom had presented with suspected mumps 2 days before the MMR vaccine was given. Thus 6 (5 symptomatic and 1 asymptomatic) cases of mumps in army recruits recently receiving MMR vaccine were not due to the vaccine but to coincidental infection with wild-type mumps virus. The probable index case was revealed by salivary mumps IgM tests. This study highlights the importance of appropriate investigation of illness associated with MMR vaccination. (+info)Mumps is typically diagnosed based on a combination of symptoms and physical examination findings. Laboratory tests such as PCR or IgG antibody testing may also be performed to confirm the diagnosis. There is no specific treatment for mumps, but supportive care such as pain management and hydration may be provided to alleviate symptoms. Vaccines are available to prevent mumps, and they are most effective when given before exposure to the virus.
The medical field has a clear definition of mumps, which is essential for accurate diagnosis, treatment, and prevention of the disease. The World Health Organization (WHO) defines mumps as "a contagious viral infection that affects the salivary glands, particularly the parotid gland." The Centers for Disease Control and Prevention (CDC) also provides guidelines for diagnosis, treatment, and prevention of mumps.
In conclusion, mumps is a viral infection that affects the salivary glands and can cause pain, discomfort, and potentially serious complications. The medical field has a clear definition of mumps, which is essential for accurate diagnosis, treatment, and prevention of the disease. Vaccines are available to prevent mumps, and they are most effective when given before exposure to the virus.
Mumps vaccine
Mumps vaccine (disambiguation)
Jeryl Lynn
MMR vaccine
Merck & Co.
Mumps
Measles: A Dangerous Illness
MMRV vaccine
1998
MMR vaccine and autism
Patrick Holford
Causes of autism
Cheryl Cohen
List of topics characterized as pseudoscience
Maia Majumder
Febrile seizure
Andrew Wakefield
Measles
Chickenpox
Lancet MMR autism fraud
Herd immunity
List of diagnoses characterized as pseudoscience
Vaccines and autism
Vaxxed
Autism spectrum
Infant mortality
Rubella
Marie McCormick
Measles vaccine
Disneyland measles outbreak
Human-to-human transmission
Shelley Deeks
Yellow fever vaccine
Division of Global Migration and Quarantine
EuroHealthNet
Kent Holtorf
Immunization of School Pupils Act
Health in Turkey
Childhood immunizations in the United States
Autism Speaks
Pharmaceutical industry
Vaccine hesitancy
Ministry of Healthcare (Azerbaijan)
History of medicine
COVID-19 pandemic in Guatemala
Varicella vaccine
Bernadette Eberlein
Health in Slovenia
Hepadnaviridae
Leon Jaroff
Attenuated vaccine
Human uses of animals
Polio vaccine
Antiviral drug
June 1966
Immigrant health care in the United States
Injection (medicine)
Mumps Vaccines for Children | CDC
Measles-Mumps-Rubella (MMR) Vaccine Information Statement | CDC
ACIP: Mumps Vaccine
MMRV (measles, mumps, rubella, and varicella) vaccine - what you need to know: MedlinePlus Medical Encyclopedia
Measles and Mumps Vaccines - Adverse Events Associated with Childhood Vaccines - NCBI Bookshelf
DailyMed - Search Results for Live Attenuated Mumps Virus Vaccine
MMR (measles, mumps, and rubella) vaccine - what you need to know: MedlinePlus Medical Encyclopedia
Browsing by Subject "Mumps Vaccine"
Mumps Outbreak at a University and Recommendation for a Third Dose of Measles-Mumps-Rubella Vaccine - Illinois, 2015-2016 |...
Measles-Mumps-Rubella-Varicella Vaccine - PubMed
Mumps Vaccine Effectiveness Against Orchitis - Volume 18, Number 1-January 2012 - Emerging Infectious Diseases journal - CDC
Timeline: another bump in the road for mumps vaccines
Mumps: How It Spreads, Outbreaks, MMR Vaccine, and More | GIDEON
Impact of a local newspaper campaign on the uptake of the measles mumps and rubella vaccine | Journal of Epidemiology &...
Mumps Vaccine Guide | Immunization Info
Measles-Mumps-Rubella Vaccine | Profiles RNS
Introduction of Mumps vaccine
A modified mumps vaccine for COVID-19 - Sciworthy
Measles, mumps and rubella (MMR) vaccine | SA Health
MS and D film footage on DBS mumps vaccine testing - Digital Collections - National Library of Medicine
Altmetric - Vaccines for measles, mumps and rubella in children
DailyMed - Search Results for Live Attenuated Mumps Virus Vaccine
Vaccines for measles, mumps, rubella, and varicella in children. | Cochrane Database Syst Rev;4: CD004407, 2020 04 20. |...
Hearing Loss Following Receipt of the Measles-Mumps-Rubells (MMR) Vaccine | Medicalalgorithms.com
Subjects: Mumps Vaccine - Digital Collections - National Library of Medicine Search Results
Measles Medication: Vitamins, Antivirals, Vaccines, Immunoglobulins
More than medical care: EMEDS prescribes hope | Health.mil
Recombinant Prefusion Measles and Mumps F and F-HN (H) Glycoproteins for Vaccine Development | Technology Transfer
Mumps-containing vaccine effectiveness during outbreaks in two schools in Guangdong, China, 2012 | Western Pacific...
Safety of measles-containing vaccines in 1-year-old children
Vaccination22
- Vaccines and high rates of vaccination have made these diseases much less common in the United States. (cdc.gov)
- Following vaccination, more than 90% of persons susceptible to mumps develop measurable antibody, which, although of considerably lower titer than that following natural infection, is protective and long-lasting. (cdc.gov)
- In some cases, your health care provider may decide to postpone MMRV vaccination until a future visit or may recommend that the child receive separate MMR and varicella vaccines instead of MMRV. (nih.gov)
- If a person develops a rash after MMRV vaccination, it could be related to either the measles or the varicella component of the vaccine. (nih.gov)
- reported that among cases of mumps, previous mumps measles rubella (MMR) vaccination offered considerable protection against orchitis, meningitis, and hospitalization ( 1 ). (cdc.gov)
- In the Netherlands, mumps vaccination, using a 2-dose schedule with the MMR vaccine against measles, mumps, and rubella, was introduced in 1987, including catch-up vaccination of 3 birth cohorts (1983-1985). (cdc.gov)
- However, a major reemergence of mumps in the Netherlands occurred during August 2007-May 2009, when a large genotype D mumps outbreak affected mainly unvaccinated persons with a religious objection to vaccination ( 6 ). (cdc.gov)
- The Dutch Centre for Infectious Disease Control advised Municipal Health Services in January 2011 to recommend MMR vaccination for university students who were unvaccinated or who had received only 1 dose of vaccine in the past. (cdc.gov)
- Information regarding the effectiveness of previous MMR vaccination against mumps complications is needed to support this policy and to predict the effect on mumps-related disease. (cdc.gov)
- Mumps outbreaks can occur in close-contact settings like universities, despite high 2-dose MMR vaccination coverage. (cdc.gov)
- Investigators identified contacts of mumps patients to verify receipt of 2 doses of MMR vaccine and recommended vaccination of susceptible close contacts if they were not fully vaccinated. (cdc.gov)
- Susceptible close contacts who had a contraindication to vaccination or who refused vaccination were excluded from public settings for 14 days (from days 12-25 following exposure to a person with probable or confirmed mumps). (cdc.gov)
- This growth can be attributed to anti-vaccination sentiment, resulting from the incorrect linking of the measles, mumps and rubella (MMR) vaccine with autism. (pharmaceutical-technology.com)
- The team found 5 to 7 weeks after vaccination the mice with the rMUV vaccine had more COVID-19 antibodies than those that received the regular MMR vaccine. (sciworthy.com)
- However, public debate over the safety of the trivalent MMR vaccine and the resultant drop in vaccination coverage in several countries persists, despite its almost universal use and accepted effectiveness . (bvsalud.org)
- Contributing factors include reduced vaccination rates (especially in the U.S) due to vaccine hesitancy and circulation of divergent strains against which the licensed MMR vaccine offers limited protection. (nih.gov)
- However, an increase in reported mumps cases during the period 2009 to 2012 casts doubt on the effectiveness of a single-dose mumps vaccination. (who.int)
- Infants who received vaccines containing live, attenuated measles were less likely to suffer a seizure within 7 to 10 days if the vaccination was administered at the recommended time, between 12 and 15 months of age, compared with older infants whose first measles dose was delayed, according to a large retrospective cohort study. (medscape.com)
- Though the measles-mumps-rubella shot would later become a focus of our present-day anti-vaccination movement, in the '50s and '60s, as historian James Colgrove, author of State of Immunity , put it in an interview, "there was very little active resistance to vaccines. (slate.com)
- The Vaccination Assistance Act, which was passed in 1962, funded grants to states to help with vaccine delivery, specifying the use of the money for vaccinations against polio, diphtheria, whooping cough, and tetanus, hoping to rectify this problem. (slate.com)
- This caused many people to avoid the vaccine, and by the 1970s, decreasing vaccination rates had brought about an increase in new infections. (nih.gov)
- Various studies indicate that vaccination, especially with pneumococcal vaccines, protects against symptomatic cases of SARS-CoV-2 infection and death. (mdpi.com)
Immunization10
- There is a positive benefit-cost ratio for mumps immunization, that is more marked when mumps vaccine is administered as MMR. (cdc.gov)
- These data summarize country introduction status of Mumps vaccine in the national immunization programme. (who.int)
- Mumps was once a universal childhood illness until routine immunization with the MMR vaccine started in the 1960s. (immunizationinfo.com)
- There were at least 186,000 cases of mumps per year before routine childhood immunization against mumps started in 1967. (immunizationinfo.com)
- What is the immunization schedule for mumps? (immunizationinfo.com)
- We found that the magnitude of increased risk of seizures following immunization with measles-containing vaccines during the second year of life depends on age," Dr. Rowhani-Rahbar and colleagues write. (medscape.com)
- Vaccines are typically recommended at an age that maximizes the likelihood of vaccine-induced protection and minimizes the risk of morbidity and mortality that would occur by delaying immunization. (medscape.com)
- The safety profile of vaccines at different ages is another important consideration in immunization policy decision making," the authors conclude. (medscape.com)
- Please also enter your immunization dates and vaccine types in the "Medical Clearances" portion for each vaccine received. (sc.edu)
- Resources for family physicians and staff to share with parents include a parent-friendly immunization schedule for children ages 0-6, and fact sheets on topics including the risks and responsibilities of choosing not to vaccinate children, and measles and the vaccine to prevent it. (aafp.org)
MMRV15
- Children 12 months through 12 years of age might receive MMR vaccine together with varicella vaccine in a single shot, known as MMRV. (cdc.gov)
- MMRV vaccine may be given at the same time as other vaccines. (nih.gov)
- Instead of MMRV, some children might receive separate shots for MMR (measles, mumps, and rubella) and varicella. (nih.gov)
- Children who are moderately or severely ill should usually wait until they recover before getting MMRV vaccine. (nih.gov)
- Seizures, often associated with fever, can happen after MMRV vaccine. (nih.gov)
- The risk of seizures is higher after MMRV than after separate MMR and varicella vaccines when given as the first dose of the two-dose series in younger children. (nih.gov)
- Now, children and adults vaccinated with the MMR (measles-mumps-rubella) or MMRV (measles-mumps-rubella-varicella) vaccines experience mild symptoms, if any [4]. (gideononline.com)
- Why do we use MMR instead of MMRV for mumps? (immunizationinfo.com)
- Children who got the first shot of MMR with the Varicella vaccine (MMRV) have twice the risk of fever-induced seizures (about 1 in 1,250) than children who got separate shots of MMR and Varicella vaccines on the same day (about 1 in 2,500). (immunizationinfo.com)
- Children between the ages of 1 and 12 years old can also get a combination vaccine called MMRV that contains both MMR and Varicella (chickenpox) vaccines. (immunizationinfo.com)
- This vaccine is also given in combination as the measles, mumps, rubella and varicella (MMRV) vaccine . (sa.gov.au)
- The vaccine is also free and given as the combination MMRV vaccine to all children at 18 months of age. (sa.gov.au)
- We grouped studies for quantitative analysis according to study design, vaccine type (MMR, MMRV, MMR+V), virus strain , and study settings. (bvsalud.org)
- Because the measles-mumps-rubella-varicella (MMRV) vaccine compared with the separate measles-mumps-rubella (MMR) and varicella (MMR + V) vaccine increases a toddler's risk for febrile seizures, we investigated whether MMRV is riskier than MMR + V and whether either vaccine elevates the risk for additional safety outcomes. (healthpartners.com)
- CONCLUSIONS: This study did not identify any new safety concerns comparing MMRV with MMR + V or after either the MMRV or the MMR + V vaccine. (healthpartners.com)
Killed mumps virus vaccine1
- A killed mumps virus vaccine was licensed for use in the United States from 1950 through 1978. (cdc.gov)
Symptoms of mumps3
- What are the symptoms of mumps? (cdc.gov)
- They injected monkeys with an unknown virus found in the saliva of people with early symptoms of mumps. (gideononline.com)
- The symptoms of mumps typically appear 16-18 days after infection, but the time ranges from 12-25 days after infection. (immunizationinfo.com)
Outbreaks5
- A third dose of MMR vaccine has been used in previous mumps outbreaks, but its effectiveness is not established. (cdc.gov)
- However, CDC has provided guidelines for use of a third dose as a control measure during mumps outbreaks in settings in which persons are in close contact with one another, where transmission is sustained despite high 2-dose MMR coverage, and when traditional control measures fail to slow transmission ( 2 ). (cdc.gov)
- Outbreaks are becoming more common in the U.S., although the number of cases is still far lower than before there was a vaccine. (immunizationinfo.com)
- Genotype G MuV is the main cause of recent outbreaks in the US and Europe, and a genotype-matched vaccine has been suggested as a solution for the recurring outbreaks. (nih.gov)
- A single dose of mumps-containing vaccine was not effective to prevent these outbreaks among preschool and school children. (who.int)
People who get mumps2
- Some people who get mumps do not have symptoms. (cdc.gov)
- From year to year, the number of people who get mumps in the United States ranges from a few hundred to a few thousand. (immunizationinfo.com)
Immunity15
- Naturally acquired mumps infection, including the estimated 30% of cases that are subclinical, confers longlasting immunity. (cdc.gov)
- The duration of vaccine-induced immunity is unknown, but observations over 15 years of live vaccine use indicate both the persistence of antibody and continuing protection against infection. (cdc.gov)
- This vaccine induced antibody, but the immunity was transient. (cdc.gov)
- Although this vaccine was in use for nearly 4 years (1963 to 1967), it was abandoned when analysis indicated that it provided only short-lived immunity and it was found that formerly vaccinated children developed severe reactions called ''atypical measles'' after their immunity waned and they became infected with the wild-type measles virus (Centers for Disease Control, 1967). (nih.gov)
- Administration of the vaccine with immune globulin of the proper titer attenuated the reaction without interfering with the induction of permanent immunity. (nih.gov)
- Using a similar production method to the polio vaccine, Enders developed a vaccine against mumps leveraging a killed virus, however, the immunity it conferred was only short lived. (pharmaceutical-technology.com)
- By attaching the protein spike to the mumps virus, the body can learn to recognize what an actual SARS-CoV-2 virus looks like and build immunity to it, like a training exercise for the immune system. (sciworthy.com)
- The live MMR vaccine is used to induce active immunity against viruses that cause measles, mumps, and rubella. (medscape.com)
- This is a live vaccine that induces active immunity against viruses that cause measles, mumps, rubella, and varicella. (medscape.com)
- 92% of mumps cases in a US mumps outbreak were children who were previously vaccinated, raising questions about the effectiveness and waning immunity of the mumps vaccine. (greenmedinfo.com)
- Gamma globulin, a product made from the blood of a person or animal who has already had a disease, bestows immunity for a much shorter period than a true vaccine. (slate.com)
- After the baby is delivered, 1 dose of vaccine is advised before being discharged home for women who don't have evidence of immunity. (stanfordchildrens.org)
- Nonpregnant adults who don't have evidence of immunity to measles, mumps, or rubella, should be vaccinated as recommended, At least one dose is advised. (stanfordchildrens.org)
- These vaccines elicit strong immune responses that can confer life-long immunity after only one or two doses. (nih.gov)
- Although this design can make vaccines safer and easier to produce, it often requires the incorporation of adjuvants to elicit a strong protective immune response because the antigens alone are not sufficient to induce adequate long-term immunity. (nih.gov)
Varicella vaccine2
- The varicella vaccine virus could be spread to an unprotected person. (nih.gov)
- Two US Food and Drug Administration-approved vaccines containing live attenuated measles are administered to American children: the measles, mumps, and rubella vaccine and the measles, mumps, rubella, and varicella vaccine. (medscape.com)
Outbreak of mumps1
- Subsequently, a genotype G outbreak of mumps started at the end of 2009, affecting mainly vaccinated adolescents. (cdc.gov)
Treatment for mumps2
- There is no treatment for mumps, and it can cause long-term health problems. (cdc.gov)
- Therefore, treatment for mumps focuses on relieving symptoms until the body can fight off the infection, usually within a few weeks. (immunizationinfo.com)
Reported in 19671
- In 1981, there was a record low of 4,729 cases, which represents a 97% decline from the 185,691 cases reported in 1967, the year of live mumps virus vaccine licensure. (cdc.gov)
Spread mumps2
- An infected person can likely spread mumps from two days before their salivary glands begin to swell to up to five days after the swelling begins. (cdc.gov)
- People who are infected can spread mumps to other people by coughing, sneezing, talking, sharing eating utensils, or touching objects with unwashed hands that are touched by others. (immunizationinfo.com)
Measles and 882
- Two MMR doses can provide 97% effectiveness against measles and 88% for mumps [2]. (gideononline.com)
- Two doses of a combination measles, mumps and rubella vaccine are 97% effective against measles and 88% against mumps. (nih.gov)
Salivary glands begin to swell1
- Mumps is contagious before the salivary glands begin to swell, and up to 5 days after the swelling begins. (immunizationinfo.com)
Meningitis3
- Before there was a vaccine, mumps was one of the most common causes of deafness and meningitis. (cdc.gov)
- Also, in rare cases, mumps can cause meningitis, which is associated with life-threatening septicaemia, as well as brain swelling and deafness, particularly when contracted younger children. (pharmaceutical-technology.com)
- You'll need the meningococcal vaccine to prevent meningitis if you are younger than 21. (sc.edu)
20194
- In 2019, the number of mumps cases in England reached heights not seen since 2009, despite the availability of the MMR vaccine on the NHS. (pharmaceutical-technology.com)
- The latest information about the 2019 Novel Coronavirus, including vaccine clinics for children ages 6 months and older. (stanfordchildrens.org)
- La información más reciente sobre el nuevo Coronavirus de 2019, incluidas las clÃnicas de vacunación para niños de 6 meses en adelante. (stanfordchildrens.org)
- Anyone who was in the ER department at Children's Hospital on July 16 (12:30 p.m. to 9:30 p.m.) should receive post-exposure vaccine by Friday, July 19, 2019. (clickondetroit.com)
Effectiveness10
- Vaccine effectiveness against complications and hospitalizations was estimated by using logistic regression, adjusting for age group and sex. (cdc.gov)
- These were weighed against potential drawbacks, which included the potential for vaccine-related side effects, associated costs, and the lack of evidence of the effectiveness of a third MMR dose. (cdc.gov)
- Additional studies are needed to determine the effectiveness of a third MMR dose as a mumps outbreak control measure in certain populations. (cdc.gov)
- However, mumps infections significantly reduced productivity and workforce effectiveness. (gideononline.com)
- The following year, Habel developed the first experimental mumps vaccine with a weakened virus and tested its effectiveness on 2,825 West Indian sugarcane plantation workers in Florida. (gideononline.com)
- To determine the effectiveness of the new vaccine, the researchers conducted several tests. (sciworthy.com)
- Fifty-one studies (10,248,159 children ) assessed vaccine effectiveness and 87 studies (13,232,509 children ) assessed the association between vaccines and a variety of harms. (bvsalud.org)
- Despite the effectiveness of the current licensed vaccines against MeV and MuV, incidences of both have increased in recent years. (nih.gov)
- In March 2012, large numbers of mumps cases in a day-care centre and primary school in Guangdong Province were investigated to estimate the effectiveness of mumps-containing vaccine. (who.int)
- Vaccine effectiveness (VE) was calculated among children in classes that had more than two mumps cases. (who.int)
Jeryl Lynn2
- Six years later his daughter, Jeryl Lynn, contracted the mumps, so he cultivated some material from her throat to develop the first live, attenuated vaccine for mumps, which was known as MumpsVax. (pharmaceutical-technology.com)
- Until it was discontinued in 2004, an inactivated so-called Jeryl Lynn strain of mumps was still used in the vaccine. (pharmaceutical-technology.com)
Polio4
- John Franklin Enders, known for his supportive work on the polio vaccine , medically advised the US War Department during the Second World War on infectious diseases, including the mumps. (pharmaceutical-technology.com)
- The idea that measles could be conquered emerged from a climate of Kennedy-era liberal altruism mixed with pro-scientific optimism prompted by the success of the polio vaccine . (slate.com)
- Simian Virus 40 (SV40) was found in polio vaccines that got injected into 100 million Americans between 1955 and 1963. (naturalnews.com)
- Sanofi Pasteur was filling vials with polio vaccine in Toronto, but the vaccine itself was being made in Europe. (theglobeandmail.com)
Pathogenesis2
- However, further research is indicated to determine whether mumps infection contributes to the pathogenesis of diabetes mellitus. (cdc.gov)
- Pathogenesis: The MMR vaccine contains live attenuated virus. (medicalalgorithms.com)
19671
- From 1967, the year of licensure of live mumps vaccine, until 1978, the number of doses of killed mumps vaccine administered is unknown, but appears to have been limited. (cdc.gov)
Highly contagious viral2
- Mumps are caused by a highly contagious viral disease, usually characterised by inflammation and swelling of the salivary glands - young adults can experience similar inflammation in their testes, possibly causing infertility. (pharmaceutical-technology.com)
- Mumps is a highly contagious viral infection caused by the mumps virus. (gideononline.com)
Fever5
- Protects your child from getting a fever and swollen glands under the ears or jaw from mumps. (cdc.gov)
- Mumps is an acute viral disease characterized by fever and swelling of the parotid or other salivary glands. (cdc.gov)
- To examine the effect of infant age on the risk for vaccine-related fever and seizures, the researchers tapped the Vaccine Safety Datalink, a collaborative effort between the Centers for Disease Control and Prevention (CDC) and 10 managed care organizations. (medscape.com)
- BACKGROUND AND OBJECTIVES: All measles-containing vaccines are associated with several types of adverse events, including seizure, fever, and immune thrombocytopenia purpura (ITP). (healthpartners.com)
- Although effective, whole-cell pertussis vaccines frequently caused minor adverse reactions such as fever and swelling at the injection site. (nih.gov)
20231
- The National Research Council's new Biologics Manufacturing Centre is one of the few that is ready to make vaccines as of spring 2023 - as many as two million doses a month. (theglobeandmail.com)
Safety Datalink1
- METHODS: Study children were aged 12 to 23 months in the Vaccine Safety Datalink from 2000 to 2012. (healthpartners.com)
Contagious disease1
- Mumps is a contagious disease caused by a virus. (cdc.gov)
Diseases13
- reported in the April 2011 issue of Emerging Infectious Diseases on the epidemiologic characteristics of the nationwide mumps outbreak in England and Wales in 2004−2005 ( 1 ). (cdc.gov)
- Science proves that vaccines are the best form of defence against a host of potentially deadly diseases and are safer and more effective than ever before. (pharmaceutical-technology.com)
- Hilleman then focused on creating vaccines against other infectious, potentially life-threatening viral diseases - measles in 1963 and rubella, or German measles, in 1969. (pharmaceutical-technology.com)
- All three diseases are preventable with the MMR vaccine (Measles-Mumps-Rubella). (immunizationinfo.com)
- Measles , mumps , rubella , and varicella ( chickenpox ) are serious diseases that can lead to serious complications , disability, and death . (bvsalud.org)
- Researchers at the Vaccine Research Center (VRC) of the National Institute of Allergy and Infectious Diseases (NIAID) used structure-guided design to create immunogen constructs aimed at stabilizing the measles and mumps F glycoproteins in their prefusion conformations. (nih.gov)
- Today's vaccines not only contain live versions of diseases they're not even addressing, but also contain GMOs, hormones from infected cows, pigs, chickens and monkeys, untested virus combinations (like H1N1), aluminum, mercury, emulsifiers and crossbred bacteria from animals, mosquitoes and diseased humans. (naturalnews.com)
- The measles, mumps, and rubella (MMR) vaccine protects people from 3 serious viral diseases. (stanfordchildrens.org)
- A combination vaccine provides protection against all 3 diseases. (stanfordchildrens.org)
- Getting an MMR vaccine is much safer than contracting any of the 3 diseases. (stanfordchildrens.org)
- Scientific research has led to the development of numerous types of vaccines that safely elicit immune responses that protect against infection, and researchers continue to investigate novel vaccine strategies for prevention of existing and emerging infectious diseases. (nih.gov)
- That technology was newly used for COVID-19 vaccines, but multiple trials are under way that use it to fight other infectious diseases, as well as cancers. (theglobeandmail.com)
- Finally, the CDC's new measles outbreak toolkit includes posters to print and display in clinics, including measles-specific 'Superbaby: Power to Protect,' 'How Vaccines Strengthen Your Baby's Immune System' and 'Stop Serious Childhood Diseases in Their Tracks. (aafp.org)
Live13
- There has been a steady decrease in the incidence rate of reported mumps cases in the United States since the introduction of the live mumps virus vaccine. (cdc.gov)
- Live mumps virus vaccine** is prepared in chick-embryo cell culture. (cdc.gov)
- Official name: Mumps Virus Vaccine, Live. (cdc.gov)
- Development of a live attenuated measles vaccine began a new era in the prevention of this disease. (nih.gov)
- 1-3] No clear evidence exists of live attenuated measles or mumps vaccine virus excretion into breastmilk. (nih.gov)
- He brought all this work together to develop the measles, mumps, rubella (MMR) live, attenuated vaccine in 1971. (pharmaceutical-technology.com)
- In 1956, the former Soviet Union was the first to develop a live mumps vaccine [7]. (gideononline.com)
- This vaccine contains small amounts of the live virus . (sa.gov.au)
- Some people may not be able to receive a live vaccine for medical reasons, so please speak with your doctor or immunisation provider for further information. (sa.gov.au)
- The existing vaccines for MeV and MuV are live attenuated virus vaccines which are administered in two subcutaneous doses at 1 year of age and as early as one month later. (nih.gov)
- Advances in tissue culture techniques in the 1950s enabled development of live-attenuated vaccines , which contain a version of the living microbe that has been weakened in the laboratory. (nih.gov)
- Live-attenuated vaccines are relatively easy to create for certain viruses, but difficult to produce for more complex pathogens like bacteria and parasites. (nih.gov)
- A NIAID-developed live-attenuated chimeric vaccine consisting of a dengue virus backbone with Zika virus surface proteins is undergoing early-stage testing in humans. (nih.gov)
Complications3
- Although deaths from mumps infections are rare, complications do exist. (gideononline.com)
- While mumps affected many children, deaths and severe complications were rare. (gideononline.com)
- What are complications of mumps? (immunizationinfo.com)
MRNA8
- They developed a new type of mRNA vaccine within two years after the start of the pandemic, but this vaccine has some limitations. (sciworthy.com)
- One limitation of the mRNA vaccine is that its protection against COVID-19 begins to decline after 3 months, so people need subsequent booster shots. (sciworthy.com)
- mRNA vaccines are also difficult and expensive to transport because they have to be stored in special freezers below -80°C (-112°F). In addition, children make up nearly 20% of COVID-19 cases, but a safe and effective mRNA vaccine for children does not yet exist. (sciworthy.com)
- A team of researchers from The Ohio State University set out to create a new COVID-19 vaccine that is as effective as the mRNA vaccine, but without these drawbacks. (sciworthy.com)
- This vaccine is easier to store than the mRNA vaccine, and is safe and effective for everyone, even children. (sciworthy.com)
- The site can make multiple types of vaccine, including the popular mRNA vaccines. (theglobeandmail.com)
- Technow said the demand for mRNA vaccines "is just getting started. (theglobeandmail.com)
- The company was founded to bring an mRNA vaccine to market, and its COVID-19 vaccine is its first successful product. (theglobeandmail.com)
Encephalitis2
- Mumps can also lead to encephalitis. (cdc.gov)
- Mumps can cause encephalitis , which can result in death, although very rarely. (immunizationinfo.com)
Spreads4
- Mumps spreads easily through coughing and sneezing. (cdc.gov)
- Like influenza, rubella, and other viral infections, mumps spreads from person to person through respiratory droplets and contaminated surfaces. (gideononline.com)
- The mumps virus spreads in saliva and causes painful face swelling. (immunizationinfo.com)
- The mumps virus spreads in saliva or mucous from the mouth, nose, and throat. (immunizationinfo.com)
COVID13
- Researchers created a new vaccine candidate for COVID-19 using the existing measles, mumps, rubella vaccine. (sciworthy.com)
- To develop a mumps-based COVID-19 vaccine, the researchers took the genome of the mumps virus and inserted a gene that would allow it to make a protein spike that is found on the surface of the SARS-CoV-2 virus. (sciworthy.com)
- The researchers injected these mice with either the new mumps-covid vaccine (rMuV) or the regular MMR vaccine as a control. (sciworthy.com)
- The research team interpreted this difference to mean their mumps-based COVID-19 vaccine was working. (sciworthy.com)
- However, they suggested the mumps-based SARS-CoV-2 vaccine could one day be incorporated into the existing MMR vaccine in a quadruple vaccine cocktail to simultaneously fight against COVID-19 and other childhood viruses. (sciworthy.com)
- The COVID vaccines have been widely shown to be safe and effective, unlike some historical examples that had significant associated risks. (slate.com)
- Doctors and scientists are blowing the whistle on Covid injections, that are not really vaccines at all. (naturalnews.com)
- Vaccine companies used fetal cell line HEK 293 to test their COVID vaccines. (fourwinds10.com)
- A Pope carrying all the accoutrement of the Roman Church can issue a statement supporting the COVID vaccine. (fourwinds10.com)
- The COVID-19 pandemic wasn't even six months old, and not a single vaccine for it had been approved for use anywhere, when Prime Minister Justin Trudeau took to a podium in Montreal to promise that Canada's National Research Council would be able to start churning out millions of doses by the end of 2021. (theglobeandmail.com)
- Still, Brown said if another coronavirus pandemic hits the world, Canada is now in a better position to make its own vaccines and medicines than it was when COVID-19 arrived three years ago. (theglobeandmail.com)
- When Canada was negotiating contracts to buy COVID-19 vaccines in the summer of 2020, then-procurement minister Anita Anand asked every company if it could make their doses in Canada. (theglobeandmail.com)
- It took too long to get its COVID-19 vaccine onto the market, and lost the race to Pfizer-BioNTech and Moderna. (theglobeandmail.com)
Influenza vaccine1
- U.S. Postal Service regulations relating to 610.11a Inactivated influenza vaccine, gen the admissibility to the United States mails eral safety test. (nih.gov)
Viruses2
- In the United States, measles virus vaccine is usually given along with attenuated rubella and mumps viruses as the measles-mumps-rubella (MMR) vaccine. (medscape.com)
- Infectious vaccine-derived rubella viruses emerge, persist, and evolve in cutaneous granulomas of children with primary immunodeficiencies. (greenmedinfo.com)
1940s1
- The first pertussis vaccines, introduced in the 1940s, comprised inactivated Bordetella pertussis bacteria. (nih.gov)
Autism2
- Thimerosol-containing vaccines are associated with autism prevalence and measles-containing vaccines are associated with serious neurological disorders. (greenmedinfo.com)
- The vaccine for measles, mumps and rubella causes autism. (aha.org)
Children14
- Two doses of the MMR shot are recommended for children by doctors as the best way to protect against measles, mumps, and rubella. (cdc.gov)
- In most children, mumps is pretty mild. (cdc.gov)
- The Centers for Disease Control and Prevention, American Academy of Family Physicians, and American Academy of Pediatrics strongly recommend children receive all vaccines according to the recommended vaccine schedule . (cdc.gov)
- Older children , adolescents , and adults also need 1 or 2 doses of MMR vaccine if they are not already immune to measles, mumps, and rubella. (cdc.gov)
- Although it has never been classified as eradicated in the UK or US, routine immunisation of children has managed to drastically reduce the incidence of mumps to benefit of all. (pharmaceutical-technology.com)
- In the past, most children got mumps. (gideononline.com)
- The vaccine is so safe the first dose is generally given to children 9 to 15 months of age, with boosters months later. (sciworthy.com)
- The MMR vaccine is a free vaccine as part of the National Immunisation Program for children at 12 months of age. (sa.gov.au)
- Mumps-containing vaccine was licensed in the 1990s in China with a single dose administered routinely to children aged 18-24 months since 2008. (who.int)
- A second dose of mumps-containing vaccine to four to five-year-old children should be considered in China. (who.int)
- The authors focused on the records of children aged between 12 and 23 months who had received measles-containing vaccine between January 2001 and December 2011, including 840,348 infants. (medscape.com)
- A group of vaccine-induced immune prepubertal children will not always prevent the spread of rubella into the rest of the community. (greenmedinfo.com)
- Children with mild illnesses may still get the vaccine. (stanfordchildrens.org)
- Some children should not get the MMR vaccine. (stanfordchildrens.org)
Infection3
- In people with serious immune system problems, this vaccine may cause an infection that may be life-threatening. (cdc.gov)
- Mumps infection during the first trimester of pregnancy may increase the rate of spontaneous abortion. (cdc.gov)
- The vaccine produces a subclinical, non-communicable infection with very few side effects. (cdc.gov)
Immune5
- People with serious immune system problems should not get MMR vaccine. (cdc.gov)
- Dr. Rowhani-Rahbar and colleagues note that a possible reason for the differing risk profiles is the ability of immune systems of 16- to 23-month-olds to mount a more rigorous response to the measles vaccine, compared with younger infants. (medscape.com)
- The nervous system, the immune system, the digestive system and the vascular system are all now bombarded by toxic vaccines that cause chronic sicknesses and death, and this is not just a long-term concern. (naturalnews.com)
- Such whole-pathogen vaccines can elicit strong protective immune responses. (nih.gov)
- Instead of the entire pathogen, subunit vaccines include only the components, or antigens, that best stimulate the immune system. (nih.gov)
Doses of vaccine2
- When he started as the minister in January 2021, he said Canada had capacity to make or at least complete the production on about 30 million doses of vaccine a year. (theglobeandmail.com)
- It's new manufacturing site in Charlottetown, built in part with a $39.8-million grant from the federal government could eventually make 160 million doses of vaccine a year. (theglobeandmail.com)
1960s1
- The MMR (measles /mumps /rubella) vaccine has been widely used since the 1960s and is one of the safest and most effective vaccines ever developed. (sciworthy.com)
MumpsVax2
- However, Mumpsvax was never available in the UK, nor was any other vaccine aimed purely at the mumps. (pharmaceutical-technology.com)
- Hilleman used his daughter's saliva swab to isolate the mumps virus and develop an attenuated mumps vaccine that he named Mumpsvax. (gideononline.com)
Cases12
- In rare cases, mumps is deadly. (cdc.gov)
- Orchitis (usually unilateral) has been reported as a complication in up to 20% of clinical mumps cases in postpubertal males, although sterility is a rare sequela. (cdc.gov)
- This coverage led to immediate control of mumps, with mumps related hospitalization dropping from 390 cases in 1987 to 11 in 1990 ( 5 ). (cdc.gov)
- IDPH and the Champaign-Urbana Public Health District (C-UPHD) conducted an investigation and identified 317 cases of mumps during April 2015-May 2016. (cdc.gov)
- During the following 2 weeks, five additional suspected cases of mumps were identified. (cdc.gov)
- The six previous suspected cases were epidemiologically linked to the same academic program as the confirmed case, which enabled IDPH to establish the existence of a mumps outbreak at the university. (cdc.gov)
- Confirmed, probable, and suspected cases were identified using the standard case definition for mumps ( 3 ). (cdc.gov)
- Last year, the number of mumps cases in England reached the highest in a decade, and this trend shows no sign of slowing down in 2020s. (pharmaceutical-technology.com)
- UK Secretary of State for Health and Social Care Matt Hancock said: "The rise in mumps cases is alarming and yet another example of the long-term damage caused by anti-vax information. (pharmaceutical-technology.com)
- However, it took until 1934 for a breakthrough when US researchers Claude Johnson and Ernest William obtained a filterable cytotropic virus from M. rhesus monkeys' parotid glands, which had been inoculated with six specimens of saliva from six cases of the mumps. (pharmaceutical-technology.com)
- For example, there were approximately 5,748 mumps cases in 2016, but only 229 cases in 2012. (immunizationinfo.com)
- Your child's healthcare provider will advise you about vaccines in these and other cases. (stanfordchildrens.org)
Severe allergic2
Hilleman1
- Enders made this strain available to other researchers, and in 1962, Maurice Hilleman and his colleagues at Merck released an attenuated measles vaccine using that strain. (slate.com)
Outcomes3
- Second, this study provides an example of the potential for current vaccine safety surveillance mechanisms to identify outcomes associated with alternate vaccine schedules. (medscape.com)
- This study provides reassurance that these outcomes are unlikely after either vaccine. (healthpartners.com)
- The design and reporting of safety outcomes in MMR vaccine studies, both pre- and post-marketing, are largely inadequate. (greenmedinfo.com)
Virus14
- Almost everyone who has not had the MMR shot will get mumps if they are exposed to the mumps virus. (cdc.gov)
- The Centers for Disease Control and Prevention and several health professional organizations state that vaccines given to a nursing mother do not affect the safety of breastfeeding for mothers or infants and that breastfeeding is not a contraindication to measles, mumps, rubella and varicella virus vaccine. (nih.gov)
- Although rubella vaccine virus might be excreted into milk, the virus usually does not infect the infant. (nih.gov)
- They concluded this virus was the same as the causative agent of mumps. (pharmaceutical-technology.com)
- When the monkeys began to develop symptoms of the disease, they confirmed that a virus caused mumps [2]. (gideononline.com)
- During wartime , particularly World War I and World War II, the military struggled with having too many of its soldiers fighting the mumps virus. (gideononline.com)
- But, it was only in 1945 that Karl Habel of the U.S. Public Health Service first cultured the mumps virus from embryonated eggs of hens. (gideononline.com)
- There is no cure for mumps and no medications to treat the virus. (immunizationinfo.com)
- Not only did the rMUV vaccine group show no signs of sickness, but their lungs showed no trace of the virus. (sciworthy.com)
- The team concluded the rMUV vaccine had completely immunized the mice against the SARS-CoV-2 virus. (sciworthy.com)
- Medications used in the treatment or prevention of measles include vitamin A, antivirals (eg, ribavirin), measles virus vaccine, and human immunoglobulin (Ig). (medscape.com)
- The Measles virus (MeV) and Mumps virus (MuV) are highly contagious paramyxoviruses that can be transmitted by respiratory droplets from or on direct contact with an infected person. (nih.gov)
- Mumps is also caused by a virus. (stanfordchildrens.org)
- One contemporary example is Havrix, an inactivated vaccine against hepatitis A virus that was developed by NIAID and partners and licensed in the United States in 1995. (nih.gov)
Merck2
- Contains footage produced by Merck Sharp, and Dohme (known as Merck and Company in the United States) of the United States Division of Biologics Standards (DBS) conducting testing of the world's first mumps vaccine, which MSD developed. (nih.gov)
- Human Papillomavirus Vaccine Made by Merck. (naturalnews.com)
Antigen2
Make vaccines2
- Between May 2020 and April 2022, Canada promised more than $1.3-billion for 12 new or expanded biomanufacturing plants to make vaccines and antibody treatments. (theglobeandmail.com)
- It took another 14 months to get a Health Canada licence to make vaccines. (theglobeandmail.com)
Onset of unilateral or bilateral1
- A mumps case was defined as a case with acute onset of unilateral or bilateral swelling of the parotid gland or other salivary glands. (who.int)