Multiple myeloma. Medical search

A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.

Abnormal immunoglobulins characteristic of MULTIPLE MYELOMA.

Inorganic or organic compounds that contain the basic structure RB(OH)2.

A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.

Specialized forms of antibody-producing B-LYMPHOCYTES. They synthesize and secrete immunoglobulin. They are found only in lymphoid organs and at sites of immune responses and normally do not circulate in the blood or lymph. (Rosen et al., Dictionary of Immunology, 1989, p169 & Abbas et al., Cellular and Molecular Immunology, 2d ed, p20)

An alkylating nitrogen mustard that is used as an antineoplastic in the form of the levo isomer - MELPHALAN, the racemic mixture - MERPHALAN, and the dextro isomer - MEDPHALAN; toxic to bone marrow, but little vesicant action; potential carcinogen.

A group of related diseases characterized by an unbalanced or disproportionate proliferation of immunoglobulin-producing cells, usually from a single clone. These cells frequently secrete a structurally homogeneous immunoglobulin (M-component) and/or an abnormal immunoglobulin.

Conditions characterized by the presence of M protein (Monoclonal protein) in serum or urine without clinical manifestations of plasma cell dyscrasia.

A rare, aggressive variant of MULTIPLE MYELOMA characterized by the circulation of excessive PLASMA CELLS in the peripheral blood. It can be a primary manifestation of multiple myeloma or develop as a terminal complication during the disease.

Any discrete, presumably solitary, mass of neoplastic PLASMA CELLS either in BONE MARROW or various extramedullary sites.

An anti-inflammatory 9-fluoro-glucocorticoid.

Transplantation of an individual's own tissue from one site to another site.

A syndecan that interacts with EXTRACELLULAR MATRIX PROTEINS and plays a role CELL PROLIFERATION and CELL MIGRATION.

The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.

Substances that inhibit or prevent the proliferation of NEOPLASMS.

A cell line derived from cultured tumor cells.

An abnormal protein with unusual thermosolubility characteristics that is found in the urine of patients with MULTIPLE MYELOMA.

Abnormal immunoglobulins synthesized by atypical cells of the MONONUCLEAR PHAGOCYTE SYSTEM. Paraproteins containing only light chains lead to Bence Jones paraproteinemia, while the presence of only atypical heavy chains leads to heavy chain disease. Most of the paraproteins show themselves as an M-component (monoclonal gammopathy) in electrophoresis. Diclonal and polyclonal paraproteins are much less frequently encountered.

Polypeptide chains, consisting of 211 to 217 amino acid residues and having a molecular weight of approximately 22 kDa. There are two major types of light chains, kappa and lambda. Two Ig light chains and two Ig heavy chains (IMMUNOGLOBULIN HEAVY CHAINS) make one immunoglobulin molecule.

The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.

Compounds that inhibit the function or proteolytic action of the PROTEASOME.

Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.

Dissolution of bone that particularly involves the removal or loss of calcium.

Diseases of BONES.

A cytokine that stimulates the growth and differentiation of B-LYMPHOCYTES and is also a growth factor for HYBRIDOMAS and plasmacytomas. It is produced by many different cells including T-LYMPHOCYTES; MONOCYTES; and FIBROBLASTS.

A lymphoproliferative disorder characterized by pleomorphic B-LYMPHOCYTES including PLASMA CELLS, with increased levels of monoclonal serum IMMUNOGLOBULIN M. There is lymphoplasmacytic cells infiltration into bone marrow and often other tissues, also known as lymphoplasmacytic lymphoma. Clinical features include ANEMIA; HEMORRHAGES; and hyperviscosity.

One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.

A specific pair of GROUP D CHROMOSOMES of the human chromosome classification.

Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.

Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.

Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.

One of the types of light chains of the immunoglobulins with a molecular weight of approximately 22 kDa.

Organic compounds which contain P-C-P bonds, where P stands for phosphonates or phosphonic acids. These compounds affect calcium metabolism. They inhibit ectopic calcification and slow down bone resorption and bone turnover. Technetium complexes of diphosphonates have been used successfully as bone scanning agents.

An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.)

A family of transmembrane glycoproteins that contain a short cytoplasmic domain, a single-span transmembrane domain, and an extracellular domain with heparin sulfate and CHONDROITIN SULFATE chains. Syndecans interact with a variety of heparin-binding INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS and may play a role in modulating cellular signaling during EMBRYONIC DEVELOPMENT, tumorigenesis, and angiogenesis.

A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.

A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.

Treatment designed to help prevent a relapse of a disease following the successful primary treatments (INDUCTION CHEMOTHERAPY and CONSOLIDATION CHEMOTHERAPY) with a long-term low-dose drug therapy.

Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.

One of the types of light chain subunits of the immunoglobulins with a molecular weight of approximately 22 kDa.

A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026)

Therapeutic act or process that initiates a response to a complete or partial remission level.

The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.

Resistance or diminished response of a neoplasm to an antineoplastic agent in humans, animals, or cell or tissue cultures.

A type of chromosome aberration characterized by CHROMOSOME BREAKAGE and transfer of the broken-off portion to another location, often to a different chromosome.

Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.

The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.

The return of a sign, symptom, or disease after a remission.

A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.

The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.

Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.

Compounds which inhibit or antagonize biosynthesis or actions of proteases (ENDOPEPTIDASES).

Connective tissue cells of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere.

A specific pair of GROUP D CHROMOSOMES of the human chromosome classification.

All of the processes involved in increasing CELL NUMBER including CELL DIVISION.

An excess of GAMMA-GLOBULINS in the serum due to chronic infections or PARAPROTEINEMIAS.

An 11-kDa protein associated with the outer membrane of many cells including lymphocytes. It is the small subunit of the MHC class I molecule. Association with beta 2-microglobulin is generally required for the transport of class I heavy chains from the endoplasmic reticulum to the cell surface. Beta 2-microglobulin is present in small amounts in serum, csf, and urine of normal people, and to a much greater degree in the urine and plasma of patients with tubular proteinemia, renal failure, or kidney transplants.

A group of sporadic, familial and/or inherited, degenerative, and infectious disease processes, linked by the common theme of abnormal protein folding and deposition of AMYLOID. As the amyloid deposits enlarge they displace normal tissue structures, causing disruption of function. Various signs and symptoms depend on the location and size of the deposits.

Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.

Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.

Removal of bone marrow and evaluation of its histologic picture.

A therapeutic approach, involving chemotherapy, radiation therapy, or surgery, after initial regimens have failed to lead to improvement in a patient's condition. Salvage therapy is most often used for neoplastic diseases.

The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.

The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.

Cell surface receptors that are specific for INTERLEUKIN-6. They are present on T-LYMPHOCYTES, mitogen-activated B-LYMPHOCYTES, and peripheral MONOCYTES. The receptors are heterodimers of the INTERLEUKIN-6 RECEPTOR ALPHA SUBUNIT and the CYTOKINE RECEPTOR GP130.

A specific pair of GROUP B CHROMOSOMES of the human chromosome classification.

Biologically active substances whose activities affect or play a role in the functioning of the immune system.

A fibroblast growth factor receptor that regulates CHONDROCYTE growth and CELL DIFFERENTIATION. Mutations in the gene for fibroblast growth factor receptor 3 have been associated with ACHONDROPLASIA; THANATOPHORIC DYSPLASIA and NEOPLASTIC CELL TRANSFORMATION.

A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei.

An immunoglobulin which accounts for less than 1% of plasma immunoglobulin. It is found on the membrane of many circulating B LYMPHOCYTES.

Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.

Neoplasms associated with a proliferation of a single clone of PLASMA CELLS and characterized by the secretion of PARAPROTEINS.

The action of a drug in promoting or enhancing the effectiveness of another drug.

Abnormal number or structure of chromosomes. Chromosome aberrations may result in CHROMOSOME DISORDERS.

A large multinuclear cell associated with the BONE RESORPTION. An odontoclast, also called cementoclast, is cytomorphologically the same as an osteoclast and is involved in CEMENTUM resorption.

Antibodies produced by a single clone of cells.

In vivo methods of screening investigative anticancer drugs, biologic response modifiers or radiotherapies. Human tumor tissue or cells are transplanted into mice or rats followed by tumor treatment regimens. A variety of outcomes are monitored to assess antitumor effectiveness.

Multi-subunit proteins which function in IMMUNITY. They are produced by B LYMPHOCYTES from the IMMUNOGLOBULIN GENES. They are comprised of two heavy (IMMUNOGLOBULIN HEAVY CHAINS) and two light chains (IMMUNOGLOBULIN LIGHT CHAINS) with additional ancillary polypeptide chains depending on their isoforms. The variety of isoforms include monomeric or polymeric forms, and transmembrane forms (B-CELL ANTIGEN RECEPTORS) or secreted forms (ANTIBODIES). They are divided by the amino acid sequence of their heavy chains into five classes (IMMUNOGLOBULIN A; IMMUNOGLOBULIN D; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M) and various subclasses.

The release of stem cells from the bone marrow into the peripheral blood circulation for the purpose of leukapheresis, prior to stem cell transplantation. Hematopoietic growth factors or chemotherapeutic agents often are used to stimulate the mobilization.

Transplantation of stem cells collected from the peripheral blood. It is a less invasive alternative to direct marrow harvesting of hematopoietic stem cells. Enrichment of stem cells in peripheral blood can be achieved by inducing mobilization of stem cells from the BONE MARROW.

Preparative treatment of transplant recipient with various conditioning regimens including radiation, immune sera, chemotherapy, and/or immunosuppressive agents, prior to transplantation. Transplantation conditioning is very common before bone marrow transplantation.

The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.

Agents and endogenous substances that antagonize or inhibit the development of new blood vessels.

A general term for various neoplastic diseases of the lymphoid tissue.

Represents 15-20% of the human serum immunoglobulins, mostly as the 4-chain polymer in humans or dimer in other mammals. Secretory IgA (IMMUNOGLOBULIN A, SECRETORY) is the main immunoglobulin in secretions.

Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue). The commonest forms are the various types of LEUKEMIA, of LYMPHOMA, and of the progressive, life-threatening forms of the MYELODYSPLASTIC SYNDROMES.

Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.

Death of a bone or part of a bone, either atraumatic or posttraumatic.

Initial drug treatment designed to bring about REMISSION INDUCTION. It is typically a short-term and high-dose drug treatment that is followed by CONSOLIDATION CHEMOTHERAPY and then MAINTENANCE CHEMOTHERAPY.

Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.

Elements of limited time intervals, contributing to particular results or situations.

The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.

Binary compounds of oxygen containing the anion O(2-). The anion combines with metals to form alkaline oxides and non-metals to form acidic oxides.

Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells. (1/5264)

Interleukin 6 (IL-6) is the major survival factor for myeloma tumor cells and induces signaling through the STAT proteins. We report that one STAT family member, Stat3, is constitutively activated in bone marrow mononuclear cells from patients with multiple myeloma and in the IL-6-dependent human myeloma cell line U266. Moreover, U266 cells are inherently resistant to Fas-mediated apoptosis and express high levels of the antiapoptotic protein Bcl-xL. Blocking IL-6 receptor signaling from Janus kinases to the Stat3 protein inhibits Bcl-xL expression and induces apoptosis, demonstrating that Stat3 signaling is essential for the survival of myeloma tumor cells. These findings provide evidence that constitutively activated Stat3 signaling contributes to the pathogenesis of multiple myeloma by preventing apoptosis. (+info)

Insertion of excised IgH switch sequences causes overexpression of cyclin D1 in a myeloma tumor cell. (2/5264)

Oncogenes are often dysregulated in B cell tumors as a result of a reciprocal translocation involving an immunoglobulin locus. The translocations are caused by errors in two developmentally regulated DNA recombination processes: V(D)J and IgH switch recombination. Both processes share the property of joining discontinuous sequences from one chromosome and releasing intervening sequences as circles that are lost from progeny cells. Here we show that these intervening sequences may instead insert in the genome and that during productive IgH mu-epsilon switch recombination in U266 myeloma tumor cells, a portion of the excised IgH switch intervening sequences containing the 3' alpha-1 enhancer has inserted on chromosome 11q13, resulting in overexpression of the adjacent cyclin D1 oncogene. (+info)

Bone marrow angiogenesis and mast cell density increase simultaneously with progression of human multiple myeloma. (3/5264)

Immunohistochemical, cytochemical and ultrastructural data showing vivid angiogenesis and numerous mast cells (MCs) in the bone marrow of 24 patients with active multiple myeloma (MM) compared with 34 patients with non-active MM and 22 patients with monoclonal gammopathy of undetermined significance (MGUS) led us to hypothesize that angiogenesis parallels progression of MM, and that MCs participate in its induction via angiogenic factors in their secretory granules. (+info)

Detection of Kaposi's sarcoma herpesvirus DNA sequences in multiple myeloma bone marrow stromal cells. (4/5264)

Whether Kaposi's sarcoma herpesvirus (KSHV) is associated with multiple myeloma (MM) remains controversial. We assayed for KSHV DNA sequences in long-term bone marrow stromal cells (BMSCs) from 26 patients with MM and 4 normal donors. Polymerase chain reaction (PCR) using primers which amplify a KSHV gene sequence to yield a 233-bp fragment (KS330233 within open reading frame 26) was negative in all cases. Aliquots of these PCR products were used as templates in subsequent nested PCR, with primers that amplify a 186-bp product internal to KS330233. BMSCs from 24 of 26 (92%) patients with MM and 1 of 4 normal donors were KSHV PCR+. DNA sequence analyses showed interpatient specific mutations (2 to 3 bp). Both Southern blot and sequence analyses confirmed the specificity of PCR results. The presence of the KSHV gene sequences was further confirmed by amplifying T 1.1 (open reading frame [ORF] K7) and viral cyclin D (ORF 72), two other domains within the KSHV genome. Immunohistochemical studies of KSHV PCR+ MM BMSCs demonstrate expression of dendritic cell (DC) lineage markers (CD68, CD83, and fascin). Serological studies for the presence of KSHV lytic or latent antibodies were performed using sera from 53 MM patients, 12 normal donors, and 5 human immunodeficiency virus (HIV)/KSHV+ patients. No lytic or latent antibodies were present in sera from either MM patients or normal donors. Taken together, these findings show that KSHV DNA sequences are detectable in BMSCs from the majority of MM patients, but that serologic responses to KSHV are not present. Ongoing studies are defining whether the lack of antibody response is caused by the absence of ongoing infection, the presence of a novel viral strain associated with MM, or underlying immunodeficiency in these patients. (+info)

Bone marrow and peripheral blood dendritic cells from patients with multiple myeloma are phenotypically and functionally normal despite the detection of Kaposi's sarcoma herpesvirus gene sequences. (5/5264)

Multiple myeloma (MM) cells express idiotypic proteins and other tumor-associated antigens which make them ideal targets for novel immunotherapeutic approaches. However, recent reports show the presence of Kaposi's sarcoma herpesvirus (KSHV) gene sequences in bone marrow dendritic cells (BMDCs) in MM, raising concerns regarding their antigen-presenting cell (APC) function. In the present study, we sought to identify the ideal source of DCs from MM patients for use in vaccination approaches. We compared the relative frequency, phenotype, and function of BMDCs or peripheral blood dendritic cells (PBDCs) from MM patients versus normal donors. DCs were derived by culture of mononuclear cells in the presence of granulocyte-macrophage colony-stimulating factor and interleukin-4. The yield as well as the pattern and intensity of Ag (HLA-DR, CD40, CD54, CD80, and CD86) expression were equivalent on DCs from BM or PB of MM patients versus normal donors. Comparison of PBDCs versus BMDCs showed higher surface expression of HLA-DR (P =.01), CD86 (P =. 0003), and CD14 (P =.04) on PBDCs. APC function, assessed using an allogeneic mixed lymphocyte reaction (MLR), demonstrated equivalent T-cell proliferation triggered by MM versus normal DCs. Moreover, no differences in APC function were noted in BMDCs compared with PBDCs. Polymerase chain reaction (PCR) analysis of genomic DNA from both MM patient and normal donor DCs for the 233-bp KSHV gene sequence (KS330233) was negative, but nested PCR to yield a final product of 186 bp internal to KS330233 was positive in 16 of 18 (88.8%) MM BMDCs, 3 of 8 (37.5%) normal BMDCs, 1 of 5 (20%) MM PBDCs, and 2 of 6 (33.3%) normal donor PBDCs. Sequencing of 4 MM patient PCR products showed 96% to 98% homology to the published KSHV gene sequence, with patient specific mutations ruling out PCR artifacts or contamination. In addition, KHSV-specific viral cyclin D (open reading frame [ORF] 72) was amplified in 2 of 5 MM BMDCs, with sequencing of the ORF 72 amplicon revealing 91% and 92% homology to the KSHV viral cyclin D sequence. These sequences again demonstrated patient specific mutations, ruling out contamination. Therefore, our studies show that PB appears to be the preferred source of DCs for use in vaccination strategies due to the ready accessibility and phenotypic profile of PBDCs, as well as the comparable APC function and lower detection rate of KSHV gene sequences compared with BMDCs. Whether active KSHV infection is present and important in the pathophysiology of MM remains unclear; however, our study shows that MMDCs remain functional despite the detection of KSHV gene sequences. (+info)

Cell adhesion mediated drug resistance (CAM-DR): role of integrins and resistance to apoptosis in human myeloma cell lines. (6/5264)

Integrin-mediated adhesion influences cell survival and may prevent programmed cell death. Little is known about how drug-sensitive tumor cell lines survive initial exposures to cytotoxic drugs and eventually select for drug-resistant populations. Factors that allow for cell survival following acute cytotoxic drug exposure may differ from drug resistance mechanisms selected for by chronic drug exposure. We show here that drug-sensitive 8226 human myeloma cells, demonstrated to express both VLA-4 (alpha4beta1) and VLA-5 (alpha5beta1) integrin fibronectin (FN) receptors, are relatively resistant to the apoptotic effects of doxorubicin and melphalan when pre-adhered to FN and compared with cells grown in suspension. This cell adhesion mediated drug resistance, or CAM-DR, was not due to reduced drug accumulation or upregulation of anti-apoptotic Bcl-2 family members. As determined by flow cytometry, myeloma cell lines selected for drug resistance, with either doxorubicin or melphalan, overexpress VLA-4. Functional assays revealed a significant increase in alpha4-mediated cell adhesion in both drug-resistant variants compared with the drug-sensitive parent line. When removed from selection pressure, drug-resistant cell lines reverted to a drug sensitive and alpha4-low phenotype. Whether VLA-4-mediated FN adhesion offers a survival advantage over VLA-5-mediated adhesion remains to be determined. In conclusion, we have demonstrated that FN-mediated adhesion confers a survival advantage for myeloma cells acutely exposed to cytotoxic drugs by inhibiting drug-induced apoptosis. This finding may explain how some cells survive initial drug exposure and eventually express classical mechanisms of drug resistance such as MDR1 overexpression. (+info)

Overexpression of the receptor for hyaluronan-mediated motility (RHAMM) characterizes the malignant clone in multiple myeloma: identification of three distinct RHAMM variants. (7/5264)

The receptor for hyaluronan (HA)-mediated motility (RHAMM) controls motility by malignant cells in myeloma and is abnormally expressed on the surface of most malignant B and plasma cells in blood or bone marrow (BM) of patients with multiple myeloma (MM). RHAMM cDNA was cloned and sequenced from the malignant B and plasma cells comprising the myeloma B lineage hierarchy. Three distinct RHAMM gene products, RHAMMFL, RHAMM-48, and RHAMM-147, were cloned from MM B and plasma cells. RHAMMFL was 99% homologous to the published sequence of RHAMM. RHAMM-48 and RHAMM-147 variants align with RHAMMFL, but are characterized by sequence deletions of 48 bp (16 amino acids [aa]) and 147 bp (49 aa), respectively. The relative frequency of these RHAMM transcripts in MM plasma cells was determined by cloning of reverse-transcriptase polymerase chain reaction (RT-PCR) products amplified from MM plasma cells. Of 115 randomly picked clones, 49% were RHAMMFL, 47% were RHAMM-48, and 4% were RHAMM-147. All of the detected RHAMM variants contain exon 4, which is alternatively spliced in murine RHAMM, and had only a single copy of the exon 8 repeat sequence detected in murine RHAMM. RT-PCR analysis of sorted blood or BM cells from 22 MM patients showed that overexpression of RHAMM variants is characteristic of MM B cells and BM plasma cells in all patients tested. RHAMM also appeared to be overexpressed in B lymphoma and B-chronic lymphocytic leukemia (CLL) cells. In B cells from normal donors, RHAMMFL was only weakly detectable in resting B cells from five of eight normal donors or in chronically activated B cells from three patients with Crohn's disease. RHAMM-48 was detectable in B cells from one of eight normal donors, but was undetectable in B cells of three donors with Crohn's disease. RHAMM-147 was undetectable in normal and Crohn's disease B cells. In situ RT-PCR was used to determine the number of individual cells with aggregate RHAMM transcripts. For six patients, 29% of BM plasma cells and 12% of MM B cells had detectable RHAMM transcripts, while for five normal donors, only 1. 2% of B cells expressed RHAMM transcripts. This work suggests that RHAMMFL, RHAMM-48, and RHAMM-147 splice variants are overexpressed in MM and other B lymphocyte malignancies relative to resting or in vivo-activated B cells, raising the possibility that RHAMM and its variants may contribute to the malignant process in B-cell malignancies such as lymphoma, CLL, and MM. (+info)

Ibandronate reduces osteolytic lesions but not tumor burden in a murine model of myeloma bone disease. (8/5264)

We determined the effects of the potent bisphosphonate ibandronate in a murine model of human myeloma bone disease. In this model, bone lesions typical of the human disease develop in mice following inoculation of myeloma cells via the tail vein. Treatment with ibandronate (4 micrograms per mouse per day) significantly reduced the occurrence of osteolytic bone lesions in myeloma-bearing mice. However, ibandronate did not prevent the mice from developing hindlimb paralysis and did not produce a detectable effect on survival. There was no significant effect of ibandronate on total myeloma cell burden, as assessed by morphometric measurements of myeloma cells in the bone marrow, liver, and spleen, or by measurement of serum IgG2b levels. These results support clinical findings that bisphosphonates may be useful for the treatment of myeloma-associated bone destruction, but suggest that other therapies are also required to reduce tumor growth. (+info)

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https://en.wikipedia.org/wiki/Benign_ethnic_neutropenia

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https://en.wikipedia.org/wiki/Pancytopenia

Multiple myeloma. 8. $1.87 billion. Cetuximab. Erbitux. Merck KGaA, Bristol-Myers Squibb. Colon and head and neck cancer. ... Gray OM, McDonnell GV, Forbes RB (Aug 2006). "A systematic review of oral methotrexate for multiple sclerosis". Multiple ... CS1 maint: Multiple names: authors list (link). *^ a b Gray O, McDonnell GV, Forbes RB (2004). Gray, Orla, ed. "Methotrexate ... CS1 maint: Multiple names: authors list (link). *^ Lodish H, Berk A, Zipursky SL, et al. (2000). Molecular Cell Biology. 4th ...

https://en.wikipedia.org/wiki/Chemotherapeutics

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https://en.wikipedia.org/wiki/Camp_Lejeune,_NC

Multiple myeloma can cause a proteinuria that is not accompanied by hypoalbuminemia, which is an important aid in making a ... Multiple myeloma: renal impairment is caused by the accumulation and precipitation of light chains, which form casts in the ... CS1 maint: Multiple names: authors list (link) *^ According to MedlinePlus, avascular necrosis is the death of the bone caused ... CS1 maint: Multiple names: authors list (link) *^ "Valores normales de proteína en orina de 24 horas". Retrieved 24 August 2012 ...

https://en.wikipedia.org/wiki/Nephrotic_syndrome

Multiple myeloma GlaxoSmithKline cedazuridine and decitabine[15] CMML Astex Pharmaceuticals Extensions[edit]. Extension to rare ...

https://en.wikipedia.org/wiki/Priority_review_voucher

Multiple myeloma (MM)Edit. Main article: Multiple myeloma. Alcohol has been suggested as a possible cause of multiple myeloma,[ ... January 2007). "Alcohol consumption and risk of Hodgkin's lymphoma and multiple myeloma: a multicentre case-control study". ... Alcohol consumption and risk of Hodgkin's lymphoma and multiple myeloma: a multicentre case-control study' by Gorini et al". ... CS1 maint: Multiple names: authors list (link). *^ "Cancer warning labels to be included on alcohol in Ireland, minister ...

https://en.m.wikipedia.org/wiki/Alcohol_and_cancer

In 1998 thalidomide was approved by the U.S. Food and Drug Administration (FDA) for use in newly diagnosed multiple myeloma (MM ... This is believed to be a main component of the mechanism in vivo by which thalidomide inhibits multiple myeloma. Additionally, ... Armoiry, X.; Aulagner, G.; Facon, T. (1 June 2008). "Lenalidomide in the treatment of multiple myeloma: a review". Journal of ... July 1994). "Bone marrow angiogenesis and progression in multiple myeloma". Br. J. Haematol. 87 (3): 503-8. doi:10.1111/j.1365- ...

https://en.wikipedia.org/wiki/Development_of_analogs_of_thalidomide

Rajkumar, S. Vincent (2018). "Multiple Myeloma". In Hensley, Martee L.; Milowsky, Matthew I.; Rajkumar, S. Vincent; Schuetze, ... Panobinostat inhibits multiple histone deacetylase enzymes, a mechanism leading to apoptosis of malignant cells via multiple ... On 23 February 2015 it received FDA accelerated approval for use in patients with multiple myeloma, and on 28 August 2015 it ... "Panobinostat chemotherapy regimen for multiple myeloma". HemOnc.org LLC. "Farydak product details". European Medicines Agency. ...

https://en.wikipedia.org/wiki/Panobinostat

Bloodgood invited Geschickter to work on multiple myeloma, and Geschickter invited his classmate Murray Copeland to work with ... Moehler, Thomas (2011-01-01). Multiple Myeloma. Springer. ISBN 978-3-540-85772-3. Retrieved 2013-01-02. Null, Gary; McDonald, ...

https://en.wikipedia.org/wiki/Charles_Freeman_Geschickter

"Pomalyst (Pomalidomide) Approved By FDA For Relapsed And Refractory Multiple Myeloma". The Myeloma Beacon. Retrieved 2013-08-10 ... "Pomalidomide Approved In Europe For Relapsed And Refractory Multiple Myeloma". The Myeloma Beacon. Retrieved 2013-08-10. ... Around that time, the wife of a man who was dying of multiple myeloma and whom standard treatments had failed, called Folkman ... Thalidomide is used as a first-line treatment in multiple myeloma in combination with dexamethasone or with melphalan and ...

https://en.wikipedia.org/wiki/Thalidomide

... multiple myeloma; or trauma. A normal thoracic spine extends from the 1st thoracic to the 12th thoracic vertebra and should ...

https://en.wikipedia.org/wiki/Kyphosis

Multiple myeloma is a type of cancer involving malignant plasma cells, called myeloma cells, within the bone marrow. Multiple ... In addition, the efficacy of OPG in bone marrow is impeded with multiple myeloma by excessive binding to syndecan-1. OPG binds ... The reduced OPG in multiple myeloma is caused by suppression of both constitutive OPG transcription and the OPG inducing ... ISBN 978-3-319-42326-5. Palumbo A, Anderson K (March 2011). "Multiple myeloma". The New England Journal of Medicine. 364 (11): ...

https://en.wikipedia.org/wiki/Osteoprotegerin

... a 68 percent higher risk of multiple myeloma, and double the risk of ALS. On July 18, 2012, the US Senate passed a bill, called ... multiple myeloma; myleodysplasic syndromes; renal toxicity; hepatic steatosis; female infertility; miscarriage; scleroderma; or ... for Disease Control and Prevention found that the contaminated water at Lejeune significantly increased the risk of multiple ...

https://en.wikipedia.org/wiki/Camp_Lejeune_water_contamination

... multiple myeloma; and bladder cancer. Numerous other cancers were determined to have inadequate or insufficient evidence of ... multiple myeloma, type II diabetes mellitus, Hodgkin's disease, non-Hodgkin's lymphoma, soft tissue sarcoma, chloracne, ... Nguyen Viet Nhan, children in the areas where Agent Orange was used have been affected and have multiple health problems, ... MS2170022626 (PDF) (Report). Archived (PDF) from the original on May 4, 2017.CS1 maint: multiple names: authors list (link) " ...

https://en.wikipedia.org/wiki/Agent_Orange

Expertscape ranks its programs in aplastic anemia and multiple myeloma as best in the world. It has been also ranked the fourth ... Dana-Farber is a member of the Multiple Myeloma Research Consortium. In addition to being a principal teaching affiliate of ... "Expertscape: Multiple Myeloma, February 2014". expertscape.com. February 2014. Retrieved 2014-02-18. "Best Hospitals 2012 ...

https://en.wikipedia.org/wiki/Dana–Farber_Cancer_Institute

ISBN 978-0-8032-7070-1. Morse, Dan F.; Dailey, R. C.; Bunn, Jennings (1974). "Prehistoric multiple myeloma". Bull N Y Acad Med ... possessed markings on her bones which suggested to investigators that she suffered from multiple myeloma. Bohannon excavated ...

https://en.wikipedia.org/wiki/Mangum_Mound_Site

Gould, SJ, The Median Isn't the Message, retrieved 1 November 2014 "Multiple Myeloma Prognosis". Multiple Myeloma Prognosis. ... also use to indicator multiple myeloma survive rate. Studies have found that most doctors are overly optimistic when making a ...

https://en.wikipedia.org/wiki/Prognosis

"David L. Lucchino - Multiple Myeloma Research Foundation". Multiple Myeloma Research Foundation. 2014-09-09. Retrieved 2018-02- ... In 2013, Lucchino joined the board of the Multiple Myeloma Research Foundation. He is a former member of the Board of Governors ...

https://en.wikipedia.org/wiki/David_Lucchino

He is best known for describing multiple myeloma, a hematological malignancy, which is called "Kahler's disease" in his honor ... Symptomatology of multiple myeloma). Whonamedit biography v t e. ...

https://en.wikipedia.org/wiki/Otto_Kahler

She is a supporter of the Multiple Myeloma Research Foundation, of which she is an honorary board member. "About Bonnie Hunt ( ... Multiple Myeloma Research Foundation. Archived from the original on July 15, 2010. Retrieved August 12, 2010. "Sneak peek: ' ...

https://en.wikipedia.org/wiki/Bonnie_Hunt

van de Donk N, Richardson PG, Malavasi F (2018). "CD38 antibodies in multiple myeloma: back to the future". Blood. 131 (1): 13- ... Daratumumab (Darzalex) which targets CD38 has been used in treating multiple myeloma. The use of Daratumumab can interfere with ... Xia C, Ribeiro M, Scott S, Lonial S (October 2016). "Daratumumab: monoclonal antibody therapy to treat multiple myeloma". Drugs ... Nooka AK, Kaufman JL, Hofmeister CC, Joseph NS (2019). "Daratumumab in multiple myeloma". Cancer. 125 (14): 2364-2382. doi: ...

https://en.wikipedia.org/wiki/CD38

"Honorary Board". Multiple Myeloma Research Foundation. Retrieved February 15, 2008. AP (October 16, 2012). "Olympic figure ... Jude's Children's Hospital and the Multiple Myeloma Research Foundation, of which he is an honorary board member. In 2012, ...

https://en.wikipedia.org/wiki/Scott_Hamilton_(figure_skater)

"Honorary Board". Multiple Myeloma Research Foundation. Archived from the original on April 16, 2008. Retrieved October 14, 2008 ... Along with Bob Costas, he supports the Multiple Myeloma Research Foundation as an honorary board member. Olbermann's father, ...

https://en.wikipedia.org/wiki/Keith_Olbermann

CS1 maint: discouraged parameter (link) "Kenneth Anderson, MD - Multiple Myeloma Research Foundation". Multiple Myeloma ... He continued his medical career at Dana-Farber as a physician and researcher with a special interest in multiple myeloma. ... Anderson sits on the board of directors for the Multiple Myeloma Research Foundation and chairs the organization's scientific ... He directs the Lebow Institute for Myeloma Therapeutics and Jerome Lipper Myeloma Center at Dana-Farber Cancer Institute and is ...

https://en.wikipedia.org/wiki/Kenneth_C._Anderson_(physician)

Rock, Hawkman), multiple myeloma. Jakov Labura, 74, Croatian Olympic rower. Frank Martin, 73, American defense attorney and ... Retrieved 2012-08-22.CS1 maint: multiple names: authors list (link) "CE saddened by death of Sir John J. Swaine". The ... Retrieved 2012-08-24.CS1 maint: multiple names: authors list (link) "'Greatest' actor Maureen Toal dies at 82". IrishTimes.com ... Retrieved 8 August 2012.CS1 maint: multiple names: authors list (link) Munatones, Steve. "Croatian Olympian Swimmer Veljko ...

https://en.wikipedia.org/wiki/Deaths_in_August_2012

In 2017, Lipman was given the Multiple Myeloma Research Foundation's "Spirit of Hope Award" for his contributions to that ... "Tony Bennett to Perform at the Multiple Myeloma Research Foundation (MMRF) Annual Fall Gala to Benefit Groundbreaking Cancer ... Multiple Myeloma Research Foundation. 16 August 2017. Retrieved 6 March 2019. Greer, Carlos (23 October 2018). "Denise Rich's ...

https://en.wikipedia.org/wiki/Avery_Lipman

In 1998 thalidomide was approved by the U.S. Food and Drug Administration (FDA) for use in newly diagnosed multiple myeloma (MM ... This is believed to be a main component of the mechanism in vivo by which thalidomide inhibits multiple myeloma. Additionally, ... Armoiry, X.; Aulagner, G.; Facon, T. (1 June 2008). "Lenalidomide in the treatment of multiple myeloma: a review". Journal of ... Cancer Multiple myeloma Drug design Thalidomide Lenalidomide Pomalidomide Apremilast Organic chemistry Health crisis ...

https://en.wikipedia.org/wiki/Immunomodulatory_imide_drug

Among other honors, Lipman also received the Multiple Myeloma Research Foundation's "Spirit of Hope Award" in 2017 and was one ... CS1 maint: discouraged parameter (link) "Tony Bennett to Perform at the Multiple Myeloma Research Foundation (MMRF) Annual Fall ... Multiple Myeloma Research Foundation. 16 August 2017. Retrieved 21 December 2018. CS1 maint: discouraged parameter (link) " ...

https://en.wikipedia.org/wiki/Monte_Lipman

"The Multiple Myeloma Research Foundation Congratulates and Supports Senator Kay Bailey Hutchsion for Her Commitment to Blood ... Hutchinson's brother has had multiple myeloma and she worked for several years to pass legislation of this type. The bill came ... and multiple myeloma. The bill was introduced as S. 1094 by Senator Kay Bailey Hutchison of Texas in June 2001. ... Multiple Myeloma Research Foundation. March 24, 2004. Feeney, Mark (May 28, 2001). "John Joseph Moakley dies at age 74". The ...

https://en.wikipedia.org/wiki/Hematological_Cancer_Research_Investment_and_Education_Act

Plasmacytoma, multiple myeloma, Waldenström macroglobulinemia and plasma cell leukemia are malignant neoplasms ("cancer") of ... Frigyesi I (Jan 2014). "Robust isolation of malignant plasma cells in multiple myeloma". Blood. 123 (9): 1336-40. doi:10.1182/ ... It is also expressed on malignant plasma cells in multiple myeloma. Compared with CD138, which disappears rapidly ex vivo, the ... Multiple myeloma is frequently identified because malignant plasma cells continue producing an antibody, which can be detected ...

https://en.wikipedia.org/wiki/Plasma_cells

T cells in multiple myeloma display features of exhaustion and senescence at the tumor site. Journal of Hematology & Oncology. ... Immunosuppression in patients who die of sepsis and multiple organ failure. JAMA. December 2011, 306 (23): 2594-605. PMC ... Invariant natural killer T cells and mucosal-associated invariant T cells in multiple sclerosis. Immunology Letters. March 2017 ...

https://zh.m.wikipedia.org/wiki/T细胞

It is most often performed for patients with certain cancers of the blood or bone marrow, such as multiple myeloma or leukemia. ... Many recipients of HSCTs are multiple myeloma[10] or leukemia patients[11] who would not benefit from prolonged treatment with ... Multiple sclerosis[edit]. Since McAllister's 1997 report on a patient with multiple sclerosis (MS) who received a bone marrow ... and in some cases multiple myeloma. However, it is less effective in rapidly growing acute leukemias.[38] ...

https://en.wikipedia.org/wiki/Bone_Marrow_Transplant

Gahrton G, Björkstrand B (2000). "Progress in haematopoietic stem cell transplantation for multiple myeloma". J Intern Med 248 ...

https://et.wikipedia.org/wiki/Tüvirakud

... multiple myeloma) and metabolic diseases (diabetes, cystinosis). Structural abnormalities of the kidneys are identified with ...

https://en.wikipedia.org/wiki/Nephrologist

Multiple myeloma. *Myelofibrosis. N. *Nasopharyngeal carcinoma. *Neuroblastoma. *Neuroendocrine tumor. *Non-Hodgkin lymphoma ...

https://simple.wikipedia.org/wiki/Category:Cancer

Mantle cell lymphoma/Multiple myeloma t(11 CCND1:14 IGH). *Anaplastic large-cell lymphoma t(2 ALK;5 NPM1) ...

https://en.wikipedia.org/wiki/Mosaicism

... multiple myeloma, enteroviral infections, malaria, muscular dystrophy, leukemoid reaction secondary to metastases to the bone ...

https://en.m.wikipedia.org/wiki/Pelger–Huet_anomaly

Bortezomib is used in the treatment of multiple myeloma.[103] Notably, multiple myeloma has been observed to result in ... "Circulating proteasome levels are an independent prognostic factor for survival in multiple myeloma". Blood. 109 (5): 2100-5. ... a proteasome inhibitor used in chemotherapy that is particularly effective against multiple myeloma ... Each end of the core particle associates with a 19S regulatory subunit that contains multiple ATPase active sites and ubiquitin ...

https://en.m.wikipedia.org/wiki/Proteasome

"Deregulation of DNA double-strand break repair in multiple myeloma: implications for genome stability". PLoS ONE 10 (3): ...

https://gl.wikipedia.org/wiki/LIG3

Johansson SG, Bennich H. Immunological studies of an atypical (myeloma) immunoglobulin" Immunology 1967; 13:381-94. ... "Incidence and prevalence of multiple allergic disorders recorded in a national primary care database". Journal of the Royal ...

https://hy.wikipedia.org/wiki/Ալերգիա

Multiple myeloma can be treated with daratumumab (Darzalex) monoclonal antibody.[6] Studies with in vitro materials and patient ... a first-in-class CD38 monoclonal antibody for the treatment of multiple myeloma". J Hematol Oncol. 9 (1): 51. doi:10.1186/ ... induces killing of multiple myeloma and other hematological tumors". J Immunol. 186 (3): 1840-8. doi:10.4049/jimmunol.1003032. ...

https://en.wikipedia.org/wiki/Antibody-dependent_cellular_cytotoxicity

Multiple myeloma[edit]. Targets: M-protein levels in blood, patient-specific assays for immunoglobulin and T cell receptor ... Uses: M-protein level in the blood is standard of care and is used for almost all patients with multiple myeloma. Patient- ...

https://en.wikipedia.org/wiki/Minimal_residual_disease

CS1 maint: Multiple names: authors list (link) *^ Chang TW, Wu PC, Hsu CL, Hung AF (2007). Anti-IgE antibodies for the ... Johansson SG, Bennich H. Immunological studies of an atypical (myeloma) immunoglobulin. Immunology 1967; 13:381-94. ...

https://en.wikipedia.org/wiki/Immunoglobulin_E_antibodies

Mantle cell lymphoma/Multiple myeloma t(11 CCND1:14 IGH). *Anaplastic large-cell lymphoma t(2 ALK;5 NPM1) ...

https://en.wikipedia.org/wiki/Monosomy_9p

Mantle cell lymphoma/Multiple myeloma t(11 CCND1:14 IGH). *Anaplastic large-cell lymphoma t(2 ALK;5 NPM1) ... She discovered Jacobsen syndrome in a family where multiple people had the disorder. She discovered that the affected children ...

https://en.wikipedia.org/wiki/Jacobsen_syndrome

... and multiple myeloma) with use of hair color.[22][23] More specifically, prolonged use of permanent dark hair dyes can double a ... This article has multiple issues. Please help improve it or discuss these issues on the talk page. (Learn how and when to ... The dyes showed high buildup on hair and gave an intense blue color, which was stable to multiple washes.[30] ...

https://en.m.wikipedia.org/wiki/Hair_dye

Leukemia, lymphoma and multiple myeloma, 1950-1987". Radiation Research. 137 (2 Suppl): S68-97. Bibcode:1994RadR..137S..68P. ... Hybridomas developed from mouse spleen cells fused to a myeloma cell line can be developed as a source for the cDNA encoding ... In general, cytotoxic chemotherapy for ALL combines multiple antileukemic drugs tailored to each person. Chemotherapy for ALL ... Start CNS prophylaxis and administer intrathecal chemotherapy via Ommaya reservoir or multiple lumbar punctures ...

https://en.m.wikipedia.org/wiki/Acute_lymphoblastic_leukemia

Lacy, MQ; Tefferi, A (April 2011). "Pomalidomide therapy for multiple myeloma and myelofibrosis: an update". Leukemia & ... multiple subcapsular infarcts often occur in the spleen, meaning that due to interrupted oxygen supply to the spleen partial or ...

https://en.m.wikipedia.org/wiki/Myelofibrosis

Malignancy: Monoclonal gammopathies (multiple myeloma and Waldenström's macroglobulinemia), Hodgkin disease, malignant ... An unusual case involving multiple organs". Acta Pathol. JPN. 30 (1): 109-20. doi:10.1111/j.1440-1827.1980.tb01308.x. PMID ... Peliosis hepatis is an uncommon vascular condition characterised by multiple, randomly distributed, blood-filled cavities ...

https://en.m.wikipedia.org/wiki/Peliosis_hepatis

Abnormal bands (spikes) are seen in monoclonal gammopathy of undetermined significance and multiple myeloma, and are useful in ... in multiple myeloma) usually appear in this band. Normal present medical procedure involves determination of numerous proteins ...

https://en.wikipedia.org/wiki/Gel_electrophoresis_of_proteins

In breast, prostate or lung cancer, multiple myeloma and some other cancers, sudden onset limb or back pain may indicate ... and about 20 percent of cases involve multiple sites of compression. The nature of the pain depends on the location of the ...

https://en.wikipedia.org/wiki/Causes_of_cancer_pain

... and multiple myeloma with AstraZeneca receiving $450 million. The second of two-deals is an agreement to study a combination ... "Eolas and AstraZeneca Agree to Develop Orexin-1 Receptor Antagonist for Multiple Indications". GEN.. ...

https://en.wikipedia.org/wiki/AstraZeneca

Real Living with Multiple Sclerosis (página oficial). *Renal and Urology News (Renalandurologynews.com) ... Clinical Lymphoma & Myeloma. *Clinical Ovarian Cancer. *Clinical Dysmorphology (página oficial). *Clinical Journal of Sports ...

https://pt.wikipedia.org/wiki/Anexo:Lista_de_revistas_científicas_de_medicina

As thalidomide is used today as a treatment for multiple myeloma and leprosy, several births of affected children were ... When multiple effects occur in a specified order, it is known as a sequence. When the order is not known, it is a syndrome. ... For 20-25% of anomalies there seems to be a "multifactorial" cause, meaning a complex interaction of multiple minor genetic ... Genetic disorders may be grouped into single-gene defects, multiple-gene disorders, or chromosomal defects. Single-gene defects ...

https://en.wikipedia.org/wiki/Congenital_disorder

Multiple copies of the V, D and J gene segments exist, and are tandemly arranged in the genomes of mammals. In the bone marrow ... Chemical similarities to polypetide chains of myeloma globulins and normal gamma-globulins". J. Exp. Med. 116 (2): 207-227. doi ... Multiple attempts have been made to improve both the way that researchers validate antibodies[77][78] and ways in which they ... Targeted monoclonal antibody therapy is employed to treat diseases such as rheumatoid arthritis,[59] multiple sclerosis,[60] ...

https://en.wikipedia.org/wiki/Antibody

... multiple myeloma, leukemia, ovarian cancer, breast cancer, small cell lung cancer, neuroblastoma, and sarcoma.[4] As an immune ... non-Hodgkin lymphoma and multiple myeloma, occurred in 5 of 119 rheumatoid arthritis patients within the first decade after ... in medical research to produce an animal model for Type 1 diabetes in a large dose as well as Type 2 diabetes with multiple low ...

https://en.m.wikipedia.org/wiki/Cyclophosphamide

The partners will perform genomic sequencing on multiple myeloma patients in order to generate data that can help guide ... Multiple Myeloma Research Foundation, UM Form Multiple Myeloma Sequencing Initiative. Aug 05, 2016 ... NEW YORK (GenomeWeb) - The Multiple Myeloma Research Foundation (MMRF) and the University of Michigan announced today that they ... have partnered to provide multiple myeloma patients with access to their genomic information to help guide their treatments. ...

https://www.genomeweb.com/cancer/multiple-myeloma-research-foundation-um-form-multiple-myeloma-sequencing-initiative

Multiple myeloma (MM), also known as plasma cell myeloma and simply myeloma, is a cancer of plasma cells, a type of white blood ... "International Myeloma Working Group (IMWG) Criteria for the Diagnosis of Multiple Myeloma". International Myeloma Working Group ... In dogs, multiple myeloma accounts for around 8% of all haemopoietic tumors. Multiple myeloma occurs in older dogs, and is not ... MGUS transforms to multiple myeloma at the rate of 1% to 2% per year, and almost all cases of multiple myeloma are preceded by ...

https://en.wikipedia.org/wiki/Multiple_myeloma

We searched Medline and the Cochrane collaboration, using the terms "myeloma" and "multiple myeloma". Wherever possible, we ... Multiple myeloma is the second most common (10-15% of all) haematological cancer.1 It is responsible for 15-20% of deaths from ... What is myeloma and who gets it?. In myeloma, neoplastic plasma cells accumulate in the bone marrow (fig 1⇓) and produce a ... Multiple myeloma. BMJ 2013; 346 doi: https://doi.org/10.1136/bmj.f3863 (Published 26 June 2013) Cite this as: BMJ 2013;346: ...

http://www.bmj.com/content/346/bmj.f3863.long

Multiple myeloma is a cancer that develops in the bone marrow , the spongy tissue found in the center of most bones. Explore ... medlineplus.gov/genetics/condition/multiple-myeloma/ Multiple myeloma. ... Multiple myeloma is a cancer that develops in the bone marrow. , the spongy tissue found in the center of most bones. The bone ... Multiple myeloma is considered a rare cancer; it accounts for about 10 percent of cancers of the blood and blood-forming ...

https://medlineplus.gov/genetics/condition/multiple-myeloma/

Description Multiple myeloma, also known as plasma cell myeloma, is the second-most common cancer of the blood. ... Definition Multiple myeloma [2] is a cancer in which antibody-producing plasma cells grow in an uncontrolled and invasive ( ... Multiple Myeloma. Definition. Multiple myeloma is a cancer in which plasma cells in the blood grow in an uncontrolled and ... Multiple Myeloma. Definition. Multiple myeloma is a cancer in which antibody-producing plasma cells grow in an uncontrolled and ...

https://www.encyclopedia.com/medicine/diseases-and-conditions/pathology/multiple-myeloma

... but not all multiple myeloma cases are the same. Learn more about the types of multiple myeloma and how they differ. ... Multiple myeloma is the second most common type of blood cancer, ... "Multiple myeloma.". Myeloma Crowd: "Types of Multiple Myeloma." ... Types of Multiple Myeloma. Articles OnMultiple Myeloma Types & Stages. Multiple Myeloma Types & Stages Multiple Myeloma Types ... Smoldering Multiple Myeloma If you have multiple myeloma, cancerous plasma cells divide and grow inside your bone marrow. ...

https://www.webmd.com/cancer/multiple-myeloma/multiple-myeloma-types

... Radiation therapy uses high-energy rays or particles to kill cancer cells. Radiation ... The type of radiation therapy most often used to treat multiple myeloma or solitary plasmacytoma is called external beam ... Rajkumar SV, Dispenzieri A. Multiple myeloma and related disorders. In: Niederhuber JE, Armitage JO, Doroshow JH, Kastan MB, ... If myeloma severely weakens the vertebral (back) bones, these bones can collapse and put pressure on the spinal cord and spinal ...

https://www.cancer.org/cancer/multiple-myeloma/treating/radiation.html

Multiple myeloma accounts for around 1% of all cancers worldwide and for about 2% of cancer-related deaths. The most common age ... Multiple myeloma affects thousands of people worldwide and is the second most common cancer of the blood only to non-Hodgkins ... Multiple Myeloma Epidemiology. News-Medical. 22 June 2021. ,https://www.news-medical.net/health/Multiple-Myeloma-Epidemiology. ... Multiple Myeloma Epidemiology. News-Medical, viewed 22 June 2021, https://www.news-medical.net/health/Multiple-Myeloma- ...

https://www.news-medical.net/health/Multiple-Myeloma-Epidemiology.aspx

... serious symptoms may manifest and affect multiple sites in the body which is why the condition is named multiple myeloma. ... The symptoms of multiple myeloma are not usually evident in the early stages of disease, which is often only detected or ... Bone pain - In multiple myeloma, abnormal plasma cells (myeloma cells) are produced in high quantities which produce abnormal ... Multiple Myeloma Symptoms. News-Medical. 25 September 2021. ,https://www.news-medical.net/health/Multiple-Myeloma-Symptoms. ...

https://www.news-medical.net/health/Multiple-Myeloma-Symptoms.aspx

Learn about multiple myeloma and Novartis Oncologys commitment to research & development for patients living with this rare ... About multiple myeloma. Multiple myeloma is an incurable cancer of plasma cells, a type of white blood cell in the bone marrow ... When myeloma cells collect in several sites, it is called multiple myeloma.1 While it is a rare cancer, it is the second most ... Multiple Myeloma Treatment Overview. Multiple Myeloma Research Foundation. Available at: http://www.themmrf.org/assets/living- ...

https://www.novartis.com/our-focus/cancer/oncology-disease-areas/multiple-myeloma

Anthropometry and multiple myeloma.. Bosetti C, Negri E, Gallus S, Dal Maso L, Franceschi S, La Vecchia C. ...

https://www.ncbi.nlm.nih.gov/pubmed/16617279?dopt=Abstract

Multiple myeloma is a type of blood cancer. Read about the basics of the disease, including what causes it, how it makes you ... "Learn the Basics About Multiple Myeloma," "Risk Factors for Multiple Myeloma," "Multiple Myeloma Symptoms," "Multiple Myeloma ... "Diagnosing Multiple Myeloma from Test Results," "How Is Multiple Myeloma Staged?" "CAR T-cell Therapy for Multiple Myeloma." ... "What Are the Risk Factors for Multiple Myeloma?" "Signs and Symptoms of Multiple Myeloma," "Staging Multiple Myeloma," " ...

https://www.webmd.com/cancer/multiple-myeloma/guide/myeloma-overview

... and signs of multiple myeloma and the medications used in treatment. Common symptoms and signs include bone pain, fatigue, and ... Main Article on Multiple Myeloma Symptoms and Signs. * Multiple Myeloma. Multiple myeloma is a form of cancer that develops in ... Multiple Myeloma Quiz. Multiple myeloma is a form of cancer. Take this quiz common signs and symptoms of multiple myeloma and ... Multiple myeloma is also referred to as myeloma.. Multiple myeloma causes a host of organ problems and symptoms. Common ...

https://www.medicinenet.com/multiple_myeloma_symptoms_and_signs/symptoms.htm

Although some patients with multiple myeloma have no symptoms at all, the following are the most common symptoms of this ... Signs and Symptoms of Multiple Myeloma. Some patients with multiple myeloma have no symptoms at all. Others can have common ... Patients with amyloidosis (discussed in What Is Multiple Myeloma?) can have some of the same problems as patients with myeloma ... Shortages of red blood cells, white blood cells, and blood platelets are common in multiple myeloma and might lead to other ...

http://www.cancer.org/cancer/multiple-myeloma/detection-diagnosis-staging/signs-symptoms.html

Multiple myeloma, is a rare cancer of the plasma cells that causes tumors in the bones. Learn more about what it is and how it ... Risk factors for multiple myeloma. (n.d.). Retrieved from https://www.themmrf.org/multiple-myeloma/multiple-myeloma-causes/ ... www.cancer.org/cancer/multiplemyeloma/detailedguide/multiple-myeloma-key-statistics. I have multiple myeloma. What should I eat ... Multiple myeloma is a cancer of the blood plasma. Multiple myeloma is a type of cancer. Cancer starts when the structure of the ...

https://www.medicalnewstoday.com/articles/161727.php?sr

... LIST. Name. Occupation. Birth. Death. Known for. Tom Brokaw. Journalist. 6-Feb-1940. Former ...

https://www.nndb.com/lists/700/000395512/

Thirteen years after his first multiple myeloma diagnosis, Stan reflects on the choices he made along the way. Heres his ... How Multiple Myeloma Affects the Body Multiple myeloma can cause problems ranging from bone pain and bone loss to kidney damage ... Understanding Multiple Myeloma Multiple myeloma, often called bone marrow cancer, is an incurable illness, but treatment that ... On top of this, his specialty wasnt multiple myeloma. You dont want to go to a general oncologist with multiple myeloma. You ...

https://www.healthgrades.com/right-care/multiple-myeloma/my-multiple-myeloma-journey-connecting-with-my-oncologist?hid=exprr

Multiple myeloma (MM) is a debilitating malignancy that is part of a spectrum of diseases ranging from monoclonal gammopathy of ... Multiple Myeloma) and Multiple Myeloma What to Read Next on Medscape. Related Conditions and Diseases. * Multiple Myeloma ... Multiple myeloma and infections: a population-based study on 9253 multiple myeloma patients. Haematologica. 2015 Jan. 100(1): ... International Myeloma Working Group Recommendations for the Treatment of Multiple Myeloma-Related Bone Disease. J Clin Oncol. ...

https://emedicine.medscape.com/article/204369-differential

Multiple myeloma may be a singularly promising target for cellular immunotherapies, according to data presented at the most ... Cite this: Cellular Immunotherapy for Multiple Myeloma Advancing Rapidly - Medscape - Jan 30, 2017. ... Myeloma Patients Could Self-administer Bortezomib at Home * U.S. Court Rejects Alvogens Patent Challenge for Celgenes Cancer ... In the case of MILs, the T cells targeted for harvesting are myeloma specific. Various strategies have been used to enhance ex ...

https://www.medscape.com/viewarticle/874989_2

Email: [email protected]myeloma.ca ©2020 Myeloma Canada - All Rights Reserved. Charitable Registration Number: 862533296RR0001 ... Myeloma Canada 1255 TransCanada, Suite 160 Dorval, QC H9P 2V4 Tel: 514 421-2242 , Toll-free: 1 888 798-5771 ... If you donate and have not already registered, you will receive periodic updates and communications from Myeloma Canada , My ...

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Our multiple myeloma patient support group provides a safe space to connect with others coping with multiple myeloma and is led ... Connect with others in our free, 15-week online support group for people diagnosed with multiple myeloma who are currently ...

https://www.cancercare.org/support_groups/123-multiple_myeloma_patient_support_group

If you have multiple myeloma, the side effects of chemotherapy can cause you to lose your appetite. Learn how to maintain a ... Multiple myeloma and nutrition. Multiple myeloma is a type of cancer that affects plasma cells, which are a part of your immune ... More in Shedding Light on Multiple Myeloma. *. To Others Living with Multiple Myeloma, Youre Not Alone ... Ask the Expert: Targeted Therapy for Multiple Myeloma. A doctor answers questions about targeted therapy for multiple myeloma. ...

https://www.healthline.com/health/cancer/multiple-myeloma-diet

Information and resources about multiple myeloma from CancerCare. ... Multiple Myeloma. *Caregiving for a Loved One with Multiple ... Multiple Myeloma. *. Q.. I am 66 years old, was diagnosed with multiple myeloma 2005, and have been in remission for 40 months ... Multiple Myeloma. CancerCare provides free, professional support services for people affected by multiple myeloma, as well as ... Additional resources include International Myeloma Foundation, Leukemia & Lymphoma Society and Multiple Myeloma Research ...

https://www.cancercare.org/diagnosis/multiple_myeloma

We report three cases of IgG kappa multiple myeloma with pseudohyperphosphatemia. The patients serum calcium levels were ... Kyle RA (1975) Multiple myeloma: review of 869 cases. Mayo Clin Proc 50:29-40Google Scholar ... Jarchowsky I, Beitner H, Plavnick L (1991) Spurious hyperphosphatemia in multiple myeloma. Harefuah 121:515-516Google Scholar ... Savage D, Garrett TJ (1986) Multiple myeloma masquerading as metastatic breast cancer. Cancer 57:923-924Google Scholar ...

https://link.springer.com/article/10.1007/BF01757346

All About Multiple Myeloma Overview of the diagnosis and treatment of multiple myeloma. Multiple myeloma is a cancer of the ... Multiple myeloma in cats M Protein in multiple myeloma Cord Blood Donation Environmental Link to Canine Cancers Treatment For ... Multiple Myeloma: The Basics This article provides basic information about Multiple Myeloma, its diagnosis and treatment. ... Including Multiple Myeloma) Treatment (PDQ®) (Health professionals) Plasma Cell Neoplasms (Including Multiple Myeloma) ...

https://www.oncolink.org/cancers/multiple-myeloma

... among four new variants that they linked to multiple myeloma. ... Multiple myeloma: link to gene involved in aging. Published ... "Multiple myeloma: link to gene involved in aging." Medical News Today. MediLexicon, Intl., 19 Aug. 2013. Web.. 22 Mar. 2018. , ... Whiteman, H. (2013, August 19). "Multiple myeloma: link to gene involved in aging." Medical News Today. Retrieved from. https ... Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk, Daniel Chubb, Niels Weinhold, Peter ...

https://www.medicalnewstoday.com/articles/264994.php?sr

... especially for relapsed multiple myeloma, herald an exciting new era in the management of this disease, experts say. ... "We have to recognize that there are probably many diseases that are buried under the name multiple myeloma. As time goes on, ... The preferred regimens for previously treated multiple myeloma now are as follows, all with category 1 evidence:. *. bortezomib ... In the area of previously treated multiple myeloma, there were several changes to the updated guidelines, including agents in ...

https://www.medscape.com/viewarticle/861408

Mark T.M., Pearse R.N. (2008) Pathophysiology of Bone Disease in Multiple Myeloma. In: Lonial S. (eds) Myeloma Therapy. ... Long-term pamidronate treatment of advanced multiple myeloma patients reduces skeletal events. Myeloma Aredia Study Group J ... International staging system for multiple myeloma. J Clin Oncol 2005; 23(15):3412-3420.PubMedCrossRefGoogle Scholar ... Multiple Myeloma Bone Marrow Stromal Cell Bone Destruction Adenomatous Polyposis Coli Gene Bone Marrow Plasma These keywords ...

https://link.springer.com/chapter/10.1007%2F978-1-59745-564-0_27

Multiple myeloma is a type of cancer that develops in your bone marrow, causing the antibodies in your blood to stop working ... Diagnosing multiple myeloma can be tricky for your doctor, as the... ... Determine if you are at risk for multiple myeloma. Some people have a higher risk of developing multiple myeloma than others. ... Diagnose-Multiple-Myeloma-Step-1.jpg\/v4-460px-Diagnose-Multiple-Myeloma-Step-1.jpg","bigUrl":"\/images\/thumb\/c\/c0\/Diagnose ...

https://www.wikihow.com/Diagnose-Multiple-Myeloma

Skip Treat multiple myeloma Tumors Cure for multiple myeloma MGUS Monoclonal Causes multiple myeloma Develop multiple myeloma Antibodies 2016 2018 Diagnosis of multiple myeloma 2019 Proteins Symptoms of multiple Patients with relapsed multiple myeloma Cancer Known as myeloma Relapse Plasmacytoma International Myeloma Working Group Treatments Cancerous Newly diagnosed multiple Cases of multiple myeloma Stages of multiple myeloma Individuals with multiple myeloma Plasma cells Survival Cells Diagnose multiple myeloma Lymphoma Bortezomib Levels in multiple myeloma patients Percent of multiple myeloma patients Cause of multiple myeloma is unknown Disease 2017 Malignant plasma Infections Lenalidomide Protein Bone marrow Refractory myeloma Relapsed and refractory multiple myeloma Risk factor for multiple myeloma People affected by multiple myeloma Treatment regimens for multiple myeloma Incurable Epidemiology Blood

If you have multiple myeloma, the side effects of chemotherapy may cause you to lose your appetite and skip meals. (healthline.com)

The type of radiation therapy most often used to treat multiple myeloma or solitary plasmacytoma is called external beam radiation therapy. (cancer.org)
There are two types of stem cell transplants to treat multiple myeloma. (wikipedia.org)
How Does Revlimid Treat Multiple Myeloma? (livestrong.com)

These myeloma cells may form tumors called plasmacytomas. (encyclopedia.com)
As they collect in the different bones, they can cause multiple tumors. (medicalnewstoday.com)
If myeloma causes bone pain due to fractures or tumors, patients who have not yet been diagnosed and advised often take over the counter pain medications of the NSAID (nonsteroidal anti-inflammatory drug) class like ibuprofen, and these medications can also be the cause of kidney problems since myeloma kidneys are more susceptible to their side effects on the kidneys. (moffitt.org)
The mechanisms are stimulation of osteoclasts as mentioned above or the development of myeloma tumors in bones. (moffitt.org)
Abnormal plasma cells, called myeloma cells, grow uncontrolled in a manner that produces bulky tumors in the body's bone marrow. (nurse.com)
Activating mutations of NRAS and KRAS are each present in about 15% of multiple myeloma tumors. (hindawi.com)
Jonathan Keats, Ph.D., head of TGen's Multiple Myeloma Research Laboratory, said: "This study, which leverages data generated at TGen as part of the Multiple Myeloma Genomics Initiative, shows how mutations acquired by multiple myeloma tumors can make a tumor resistant to specific therapies and highlights the importance of TGen's precision medicine approaches. (redorbit.com)
Multiple myeloma is characterized by the presence of multiple tumors. (thirdage.com)
Multiple myeloma is characterized by the presence of multiple malignant plasma cell tumors known as plasmacytomas. (thirdage.com)
These myeloma cells multiply randomly and without order, forming collections of cells called tumors that accumulate most commonly in the bone marrow and on the surfaces of different bones in the body. (drugs.com)
In this cancer , plasma cells (a type of white blood cell ) accumulate in the bone marrow, giving rise to tumors in multiple bones of the body. (rxlist.com)
It is called multiple myeloma because it is characterized by plasma cell tumors in bones in multiple parts of the body. (va.gov)
In tackling the dilemma of treatment failure, the researchers identified a cancer cell maturation hierarchy within multiple myeloma tumors and demonstrated the critical role of myeloma cell maturation in proteasome inhibitor sensitivity. (medindia.net)
W. Michael Kuehl, M.D., chief of the Molecular Pathogenesis of Myeloma Section of the CCR Genetics Branch and a co-director of the study, stated that "Our studies suggest that activation of the NF-kappaB pathway by signals from normal bone marrow cells is critical not only for survival of normal plasma cells but also for pre-malignant and malignant myeloma tumors. (nih.gov)
The importance of this pathway is highlighted by essential mutations in some myeloma tumors. (nih.gov)
Regardless of whether or not there are mutations in this pathway, most myeloma tumors may be sensitive to NF-kappaB inhibitors. (nih.gov)

While there is no cure for multiple myeloma, there are FDA-approved treatments to target the cancer and slow down the spread of the disease. (fda.gov)
Introducing the IMF's Black Swan Research Initiative® Understanding that the search for a cure for multiple myeloma demands constant innovation, the IMF has launched the Black Swan Research Initiative®, a unique project to develop the first definitive cure for myeloma. (myeloma.org)
Our findings reveal a way forward toward a cure for multiple myeloma, which involves targeting both the progenitor cells and the plasma cells at the same time," says Rodger Tiedemann, M.D., a hematologist specializing in multiple myeloma and lymphoma at Princess Margaret. (redorbit.com)
WebMD states that currently there is no cure for multiple myeloma and that the treatments move slowly in dealing with the disorder. (reference.com)
As of September 2014, there is no known cure for multiple myeloma, according to Mayo Clinic. (reference.com)
There's no cure for multiple myeloma. (mdanderson.org)

But MGUS doesn't cause other symptoms of myeloma. (webmd.com)
In those with MGUS, myeloma or another cancer develops at a rate of 1% per year. (medicinenet.com)
In addition we know that a common condition called MGUS predisposes to the development of myeloma. (medicalnewstoday.com)
A monoclonal proliferation of PC is also present in other conditions that can be considered as preclinical phases of MM, including monoclonal gammopathy of undetermined significance (MGUS) and asymptomatic or smoldering myeloma (SMM). (hindawi.com)
The rate of evolution from these preclinical conditions to an overt myeloma is very low and it has been calculated to be 1% per year for MGUS and 10% per year for SMM. (hindawi.com)
However, while both MGUS and SMM lack the clinical features of MM, they harbor the same genetic alterations of symptomatic myeloma [ 4 , 5 ]. (hindawi.com)
Besides additional, acquired genetic and epigenetic changes of PC, it is likely that a "permissive" microenvironment plays a significant role in the evolution from MGUS to symptomatic myeloma [ 6 ]. (hindawi.com)
Another risk factor for multiple myeloma is a history of monoclonal gammopathy of undetermined significance (MGUS). (healthline.com)
However, MGUS can sometimes develop into multiple myeloma over time. (healthline.com)
Multiple myeloma almost always starts out as a relatively benign condition called monoclonal gammopathy of undetermined significance (MGUS). (mayoclinic.org)
MGUS , like multiple myeloma, is marked by the presence of M proteins - produced by abnormal plasma cells - in your blood. (mayoclinic.org)
Those that have been diagnosed with solitary plasmacytoma, or monoclonal gammopathy of uncertain significance (MGUS), are also at risk for developing mutlple myeloma. (reference.com)
All myeloma patients started with MGUS, but not all patients with MGUS will develop myeloma," says Dr. Alan Feiner, a hematologist-oncologist at Rocky Mountain Cancer Center in Denver, Colo. "About one third of MGUS patients will eventually develop multiple myeloma, but MGUS usually causes no problems. (healthgrades.com)
About 20 to 30% of individuals with MGUS if followed up for a very long time will go on to develop myeloma or some other related disease such as lymphoma . (labtestsonline.org.uk)
Some of the tests used to diagnose and/or follow multiple myeloma are used to monitor patients with MGUS. (labtestsonline.org.uk)

All of the paraproteins from any one individual are monoclonal (identical) because the myeloma cells are identical clones of a single plasma cell. (encyclopedia.com)
In about 75% of multiple myeloma cases, the malignant plasma cells also produce monoclonal light chains, or incomplete Igs. (encyclopedia.com)
Two monoclonal antibodies - options for use in relapsed multiple myeloma - are also new in the updated guidelines. (medscape.com)
Multiple Myeloma (MM) is a systemic hematologic disease due to uncontrolled proliferation of monoclonal plasma cells (PC) in bone marrow (BM). (hindawi.com)
Blood and urine tests for monoclonal proteins - These are the useless antibodies or antibody fragments called light chains that come from the clone of myeloma cells. (moffitt.org)
Monoclonal proteins can usually be detected in the blood and/or urine of multiple myeloma patients. (moffitt.org)
Because the monoclonal protein is sometimes found in patients who do not have multiple myeloma, further testing will be required if it is identified in order to reach a definitive diagnosis. (moffitt.org)
Today, the U.S. Food and Drug Administration granted accelerated approval to Xpovio (selinexor) tablets in combination with the corticosteroid dexamethasone for the treatment of adult patients with relapsed refractory multiple myeloma (RRMM) who have received at least four prior therapies and whose disease is resistant to several other forms of treatment, including at least two proteasome inhibitors, at least two immunomodulatory agents, and an anti-CD38 monoclonal antibody. (fda.gov)
Multiple myeloma (MM) is a hematologic malignancy characterized by the accumulation of monoclonal plasma cells in the bone marrow (BM), over 10% by definition [ 1 ]. (hindawi.com)
Normally, multiple myeloma begins as a condition called monoclonal gammopa. (reference.com)
In multiple myeloma, the plasma cells make an abnormal substance known as a monoclonal protein. (healthgrades.com)
But having monoclonal proteins in your blood does not mean you have multiple myeloma. (healthgrades.com)
This immunoglobulin may also be called monoclonal immunoglobulin, myeloma protein, or simply M protein. (drugs.com)
Multiple myeloma (MM) is characterized by the neoplastic proliferation of plasma cells producing a monoclonal immunoglobulin. (uptodate.com)
Sometimes people will produce abnormal amounts of identical copies of the same immunoglobulin (also known as monoclonal gammopathy) but not have any of the symptoms or complications of multiple myeloma. (labtestsonline.org.uk)
Multiple myeloma is a monoclonal tumor of plasma cells, and its development is preceded by a premalignant tumor with which it shares genetic abnormalities, including universal dysregulation of the cyclin D/retinoblastoma (cyclin D/RB) pathway. (jci.org)
Multiple myeloma (MM) is an age-dependent monoclonal tumor of BM plasma cells (PCs). (jci.org)
There are two conditions that can be precursors to multiple myeloma: monoclonal gammopathy of undetermined significance and smoldering multiple myeloma. (mdanderson.org)
The introduction of CD38-targeting monoclonal antibodies (CD38 MoABs), daratumumab and isatuximab, has significantly impacted the management of patients with multiple myeloma (MM). Outcomes of patients with MM refractory to CD38 MoABs have not been described. (nature.com)

Scientists aren't sure what causes multiple myeloma. (webmd.com)
What causes multiple myeloma? (healthline.com)

In Western industrialized countries, approximately four people in 100,000 develop multiple myeloma. (encyclopedia.com)
African Americans are more than twice as likely to develop multiple myeloma than white Americans. (thirdage.com)
Veterans who develop multiple myeloma and were exposed to Agent Orange or other herbicides during military service do not have to prove a connection between their disease and service to be eligible to receive VA health care and disability compensation. (va.gov)
Are some people more likely to develop multiple myeloma? (mdanderson.org)

Multiple myeloma ( MM ), also known as plasma cell myeloma and simply myeloma , is a cancer of plasma cells , a type of white blood cell that normally produces antibodies . (wikipedia.org)
[10] Multiple myeloma is diagnosed based on blood or urine tests finding abnormal antibodies, bone marrow biopsy finding cancerous plasma cells, and medical imaging finding bone lesions. (wikipedia.org)
Most people with myeloma make antibodies known as immunoglobulins. (webmd.com)
It involves M proteins, which are abnormal antibodies made by myeloma cells. (webmd.com)
Bone pain - In multiple myeloma, abnormal plasma cells (myeloma cells) are produced in high quantities which produce abnormal antibodies. (news-medical.net)
Multiple myeloma is an incurable cancer of plasma cells, a type of white blood cell in the bone marrow that produces antibodies and helps fight infection. (novartis.com)
Multiple myeloma features abnormal proliferation of plasma cells in the bone marrow, destructive bone lesions, and the production of abnormal proteins, specifically antibodies. (medicinenet.com)
Multiple myeloma is a form of cancer that develops in plasma cells, the white blood cells that make antibodies. (medicinenet.com)
Multiple myeloma is a type of cancer that develops in your bone marrow, causing the antibodies in your blood to stop working correctly. (wikihow.com)
Cancerous plasma cells (= myeloma cells) can grow and multiply, "blindly" produce useless and sometimes incomplete antibodies (called light chains) and release molecules (called cytokines) that can affect healthy cells around them. (moffitt.org)
If myeloma produces incomplete antibodies called light chains, they are small enough to be filtered by the kidneys and if they reach high concentrations in the kidneys they can fall out of solution, form casts, and trigger an inflammatory reaction that results in kidney failure. (moffitt.org)
If multiple myeloma is suspected in an individual who is experiencing frequent infections, fatigue, anemia, bone pain or has laboratory findings such as low kidney function, high calcium or high total protein (excess useless antibodies released by myeloma increase the total protein value), testing may be recommended. (moffitt.org)
Multiple myeloma is cancer that begins in plasma cells (white blood cells that produce antibodies) and may also be referred to as plasma cell myeloma. (fda.gov)
The myeloma cells continue trying to produce antibodies, as healthy plasma cells do, but the myeloma cells produce abnormal antibodies that the body can't use. (mayoclinic.org)
But myeloma plasma cells make abnormal antibodies. (cigna.com)
Multiple myeloma is a bone marrow-based cancer that arises in plasma cells, a type of white blood cells that produce proteins that help the body fight infections (known as antibodies). (patientslikeme.com)
CAR T-cells and bispecific antibodies as single agents may offer new hope to patients with myeloma, but they also may provide the opportunity for new combinations with other novel targeted therapies under investigation. (bms.com)
The patient's blood is checked for abnormal antibodies produced by myeloma cells. (aaos.org)

A 2016 study concluded that stem cell transplant is the preferred treatment of multiple myeloma. (wikipedia.org)
In 2016, Myeloma Canada produced two patient submissions to pCODR for daratumumab, in combination with dexamethasone, and one for ixazomib plus lenalidomide (Revlimid®) and dexamethasone. (newswire.ca)

According to the American Cancer Society , more than 30,000 people in the United States will be newly diagnosed with multiple myeloma in 2018. (healthline.com)
41 NCCN Guidelines for Patients ® : Multiple Myeloma, 2018 4 Treatment guide Solitary plasmacytoma Follow-up tests After you finish primary treatment, you should have follow-up tests every 3 to 6 months. (nccn.org)

The most widely accepted schema for the diagnosis of multiple myeloma (MM) uses particular combinations of laboratory, imaging, and procedure findings as diagnostic criteria. (medscape.com)
International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma. (medscape.com)
Several tests are used to confirm a diagnosis of multiple myeloma, including x-rays, bone scans, a bone biopsy, and a blood test. (aaos.org)

20 NCCN Guidelines for Patients ® : Multiple Myeloma, 2019 2 Testing for myeloma Tissue tests Tissue biopsy If you have a solitary plasmacytoma, a tissue biopsy may be done to remove a sample of the mass for testing. (nccn.org)
21, 2019 (HealthDay News) -- Patients with a form of blood cancer known as multiple myeloma who haven't responded to other therapies might have a new weapon against the disease, researchers say. (thefreedictionary.com)
Nonclinical efficacy data presented at the 2019 American Society of Hematology (ASH) Annual Meeting demonstrated that CD38-ARMs are able to kill multiple myeloma cells by antibody-dependent cellular cytotoxicity without depleting CD38-expressing immune cells. (prnewswire.com)

Some people with multiple myeloma don't make enough M proteins or light chains for tests to show they have it. (webmd.com)
You may have lab tests every 3 to 6 months to check for an increase in M proteins or signs of the organ damage active myeloma can cause. (webmd.com)
People with smoldering multiple myeloma have more M proteins in their blood or more myeloma plasma cells in their bone marrow. (webmd.com)
Sometimes, the abnormal proteins produced by myeloma cells are toxic to nerves. (cancer.org)
These proteins may be caused by multiple myeloma or other conditions. (healthline.com)
However, a team of researchers led by Xin-Yan Pei, M.D., Ph.D., and Steven Grant, M.D., recently published the findings of a study in the journal PLoS ONE demonstrating that a novel drug combination both reduces Mcl-1 expression and disrupts its interactions with other proteins to effectively kill multiple myeloma cells. (eurekalert.org)
Multiple myeloma is a cancer caused by an overproduction of certain proteins from white blood cells. (va.gov)
Some forms of multiple myeloma produce proteins that can be detected with a urine analysis. (aaos.org)
Finally, myeloma can cause kidney problems due to overproduction of proteins that deposit in the kidneys by the myeloma cells. (mdanderson.org)

The symptoms of multiple myeloma are not usually evident in the early stages of disease, which is often only detected or diagnosed as a result of routine blood and urine tests. (news-medical.net)
Generalized symptoms of multiple myeloma include unexplained fatigue, bone pain and weight loss. (news-medical.net)
The signs and symptoms of multiple myeloma depend on the stage of the cancer and the general health of the patient. (medicalnewstoday.com)
What are the symptoms of multiple myeloma? (healthline.com)
The symptoms of multiple myeloma vary depending on the person. (healthline.com)
Signs and symptoms of multiple myeloma can vary and, early in the disease, there may be none. (mayoclinic.org)
This leads to the development of symptoms of multiple myeloma - kidney damage, bone pain, and fractures due to bone damage. (newsmax.com)
Symptoms of multiple myeloma usually don't appear until the disease is more advanced. (drugs.com)

NEW YORK (MarketWatch) -- Amgen Inc. shares AMGN, -0.79% climbed 3.5% in premarket trade Monday, after the company said a late-stage trial of a treatment for patients with relapsed multiple myeloma had positive results. (marketwatch.com)
Revlimid, manufactured by Celgene, is a derivative of of thalidomide that has extended survival in patients with relapsed multiple myeloma. (livestrong.com)
Does lenalidomide plus dexamethasone improve outcome in patients with relapsed multiple myeloma? (nih.gov)

Multiple myeloma is the second most common (10-15% of all) haematological cancer. (bmj.com)
Although myeloma remains an incurable cancer, survival is improving, and newly diagnosed patients are now projected to live for around five years. (bmj.com)
Multiple myeloma is a cancer in which antibody-producing plasma cells grow in an uncontrolled and invasive (malignant) manner. (encyclopedia.com)
Multiple myeloma , also known as plasma cell myeloma, is the second-most common cancer of the blood. (encyclopedia.com)
Multiple myeloma accounts for approximately 1% of all cancers and 2% of all deaths from cancer. (encyclopedia.com)
Multiple myeloma is one of the leading causes of cancer deaths among African Americans . (encyclopedia.com)
Multiple myeloma affects thousands of people worldwide and is the second most common cancer of the blood only to non-Hodgkin's lymphoma. (news-medical.net)
The American Cancer Society predicted that in 2013, around 22,350 new cases of multiple myeloma would be diagnosed (12,440 in men and 9,910 in women) and around 10,710 deaths would occur (6,070 in men and 4,640 in women). (news-medical.net)
3 After initial therapy, it is common for individuals with multiple myeloma to become less responsive to therapy or eventually experience a relapse, when the cancer returns. (novartis.com)
Multiple myeloma is a type of blood cancer. (webmd.com)
When your doctor diagnoses multiple myeloma, they'll try to give you an idea of how much the cancer has grown or spread in your body. (webmd.com)
There are many myeloma cells, and the cancer has destroyed three or more areas of bone. (webmd.com)
Multiple myeloma is a cancer of certain cells of the bone marrow called plasma cells. (medicinenet.com)
Multiple myeloma is a form of bone marrow cancer . (medicinenet.com)
The American Cancer Society (ACS) estimates the risk of developing multiple myeloma over a lifetime as 1 in 143 or 0.7 percent . (medicalnewstoday.com)
It was during my first oncology visit with Dr. York that I received the diagnosis: I had multiple myeloma, a type of blood cancer. (healthgrades.com)
Multiple myeloma is a type of cancer that affects plasma cells, which are a part of your immune system. (healthline.com)
Cancer Care provides free, professional support services for people affected by multiple myeloma, as well as multiple myeloma treatment information and additional resources. (cancercare.org)
Savage D, Garrett TJ (1986) Multiple myeloma masquerading as metastatic breast cancer. (springer.com)
Multiple myeloma is a cancer of the blood (hematologic cancer) in which one population of clonal (identical) plasma cells starts to reproduce uncontrollably. (oncolink.org)
Scientists from The Institute of Cancer Research in the UK found a genetic variant called TERC among four new variants that they linked to multiple myeloma - a form of cancer that affects immune cells produced in the bone marrow for circulation in the blood. (medicalnewstoday.com)
Myeloma is a relatively uncommon cancer according to the American Cancer Society statistics, with a 1 in 149 risk of developing the disease in the US. (medicalnewstoday.com)
For the study, the research team analyzed the genetic make-up of 4,692 patients who had myeloma, and compared this with DNA of 10,990 people who did not have the blood cancer. (medicalnewstoday.com)
They add that if the link between TERC and myeloma is confirmed, this could lead to new treatments of the blood cancer. (medicalnewstoday.com)
Richard Houlston, professor of molecular and population genetics at The Institute of Cancer Research ( ICR ), explains: "Our study has taken an important step forward in understanding the genetics of myeloma, and suggested an intriguing potential link with a gene that acts as a cell's internal timer. (medicalnewstoday.com)
HOLLYWOOD, Florida - In the latest version of the multiple myeloma guidelines issued by the National Comprehensive Cancer Network (NCCN), three major changes reflect the rapid advances in the diagnosis and treatment of this disease. (medscape.com)
The updated guidelines were presented here at the NCCN 21st Annual Conference by Kenneth C. Anderson, MD, Kraft Family Professor of Medicine at Harvard Medical School and the Dana-Farber Cancer Institute in Boston, and chair of the NCCN Multiple Myeloma/Systemic Light Chain Amyloidosis/Waldenström's Macroglobulinemia Panel. (medscape.com)
If the cancer has spread, see Guide 1 on page 16 for recommended testing to assess the severity of multiple myeloma and its symptoms. (nccn.org)
Next steps  If tests show the cancer has spread, the next treatment options depend on the severity of myeloma and its symptoms. (nccn.org)
According to Stanford University, multiple myeloma is rare, accounting for only 1 percent of all cancer cases in the United States. (healthline.com)
Among the many frustrating things about the blood cancer known as multiple myeloma is the fact that it's hard to predict who will get it. (healthcentral.com)
But multiple myeloma cancer cells are often found to have an extra chromosome or may be missing a part of one chromosome. (healthcentral.com)
Reuters) - Amgen Inc's Kyprolis drug failed to extend survival compared to standard care in a trial involving patients with advanced multiple myeloma, a type of blood cancer that develops in the bone marrow. (yahoo.com)
Multiple myeloma is a cancer of antibody producing cells, called plasma cells, which are located in the bone marrow. (moffitt.org)
Multiple myeloma is a hematological cancer that involves a type of white blood cell called a plasma cell. (nurse.com)
According to the American Cancer Society, in 2015 about 26,850 people will be diagnosed with multiple myeloma (14,090 men and 12,760 women). (nurse.com)
At Moffitt Cancer Center, we perform extensive research and have an active multiple myeloma clinical trials program. (moffitt.org)
Each year, more than 25,000 Americans are diagnosed with multiple myeloma, a form of blood cancer that often develops resistance to therapies. (eurekalert.org)
Not only was the combination therapy effective against multiple myeloma cells, it notably did not harm normal bone marrow cells, raising the possibility of therapeutic selectivity," says Grant, the study's lead investigator and Shirley Carter Olsson and Sture Gordon Olsson Chair in Cancer Research, associate director for translational research and program co-leader of Developmental Therapeutics at VCU Massey Cancer Center. (eurekalert.org)
Researchers have discovered why multiple myeloma, a difficult to cure cancer of the bone marrow, frequently recurs after an initially effective treatment that can keep the disease at bay for up to several years. (redorbit.com)
The research team initially analyzed 7,500 genes in multiple myeloma cells to identify genes which when suppressed made cancer cells resistant to a common class of drugs called proteasome inhibitors such as bortezomib or carfilzomib. (redorbit.com)
According to the American Cancer Society, there are three stages of multiple myeloma. (reference.com)
The survival rates for multiple myeloma are 62, 44 and 29 months for stages one, two and three, respectively, according to Cancer.org. (reference.com)
As explained in the Introduction , a person with a small amount of M protein in their blood has a 1% to 2% chance of developing myeloma, lymphoma , or another blood-related cancer called Waldenstrom's macroglobulinemia per year (see the Stages section for more information). (cancer.net)
Multiple myeloma is a form of cancer that is caused by the malignant and abnormal growth of plasma cells. (thirdage.com)
The most comprehensive genetic study to date of the blood cancer multiple myeloma has revealed that the genetic landscape of the disease may be more complicated than previously thought. (eurekalert.org)
What this new work shows us is that when we treat an individual patient with multiple myeloma, it's possible that we're not just looking at one disease, but at many - in the same person, there could be cancer cells with different genetic make-ups," said co-senior author Todd Golub, the Broad Institute's Chief Scientific Officer and Charles A. Dana Investigator in Human Cancer Genetics at the Dana-Farber Cancer Institute. (eurekalert.org)
In a detailed study of samples from more than 200 multiple myeloma patients, Golub and colleagues identified frequent mutations in several key genes known to play an important role in cancer including KRAS, NRAS, and BRAF. (eurekalert.org)
Even though nearly 33,000 Americans are diagnosed with multiple myeloma each year, many people are not familiar with this form of blood cancer. (healthgrades.com)
Here's what three multiple myeloma specialists want you to know about this uncommon blood cancer . (healthgrades.com)
Multiple myeloma is not a bone cancer, but much of the damage it causes is related to the bones in some way," says Dr. Feiner. (healthgrades.com)
In laboratory experiments, multiple myeloma patients had increased levels of sclerostin, which correlated with tumor burden, Homare Eda, MD, PhD, research fellow in cancer at Harvard Medical School in Boston, told MedPage Today . (medpagetoday.com)
David Vesole, MD, PhD, co-chief of the myeloma division at John Theurer Cancer Center at Hackensack University Hospital, New Jersey, noted that scientists have been looking for various targets in multiple myeloma and have had success in finding substances in the laboratory that seem like promising targets. (medpagetoday.com)
They determined that blood plasma sclerostin levels were higher in the multiple myeloma patients when compared to three leukemia patients, 40 gastric cancer patients, and four healthy volunteers. (medpagetoday.com)
Multiple myeloma is a type of cancer that forms in plasma cells (also called mature B-lymphocytes), which are a type of white blood cell that is made in the bone marrow. (drugs.com)
One cancer being tested is multiple myeloma, a disease that affects blood cells. (bms.com)
So a new potentially successful bispecific antibody therapy might, for example, have one arm that binds to myeloma cells via BCMA and another that binds to T-cells, one of the immune system's top cancer assassins. (bms.com)
If there's one disease that most shows the effects of recent improvements in cancer treatment, it's multiple myeloma. (harvard.edu)
Multiple myeloma treatment is a very active area of cancer research. (cancer.net)
The reason, explains research published online today in Cancer Cell , is intrinsic resistance found in immature progenitor cells that are the root cause of the disease - and relapse - says principal investigator Dr. Rodger Tiedemann, a hematologist specializing in multiple myeloma and lymphoma at the Princess Margaret, University Health Network (UHN). (medindia.net)
Multiple myeloma is an uncommon cancer. (cancervic.org.au)
Multiple myeloma (also known as "myeloma") is the most common primary bone cancer. (aaos.org)
Multiple myeloma is named for the "clock face" appearance of the cancer cells when seen under a microscope. (aaos.org)
Research investigators have identified molecular changes in multiple myeloma cells that activate an important biological pathway associated with cell growth and survival, thereby revealing potential new targets for drugs to treat this cancer. (nih.gov)
The researchers, led by a team from the National Cancer Institute (NCI), part of the National Institutes of Health, have shown that malignant cells in multiple myeloma frequently harbor mutations that activate what is called the NF-kappaB signaling pathway, which plays a key role in promoting cell growth and preventing programmed cell death. (nih.gov)
This is one of the largest collaborative translational cancer research efforts of its kind," said John Shaughnessy, Jr., Ph.D., director of the Donna D. and Donald M. Lambert Laboratory of Myeloma Genetics and chief of Basic Sciences at the Myeloma Institute for Research and Therapy at the University of Arkansas for Medical Sciences, Little Rock, Ark. (nih.gov)
Aflibercept may be able to carry cancer-killing substances directly to multiple myeloma cells. (clinicaltrials.gov)
It may also stop the growth of multiple myeloma by blocking blood flow to the cancer. (clinicaltrials.gov)
MONTREAL , July 4, 2017 /CNW/ - Multiple myeloma, commonly referred to as myeloma, is an incurable cancer of the plasma cells found in the bone marrow. (newswire.ca)
Myeloma Canada is a non-profit, charitable organization created by, and for people living with multiple myeloma, a relatively unknown cancer of the plasma cells. (newswire.ca)

When plasma cells become cancerous and multiply, they are known as myeloma cells. (novartis.com)
Multiple myeloma is also known as myeloma or plasma cell myeloma. (medicalnewstoday.com)
Together, these biomarkers and the CRAB criteria are known as myeloma-defining events (MDEs). (wikipedia.org)

In addition, recent advances in technology and the mapping of the human genome have enabled scientists to discover that abnormalities in the expression, or levels, of some specific genes are associated with the risk for early relapse of multiple myeloma. (healthcentral.com)
The identification of genes that, when abnormally expressed, are associated with risk for relapse has led to the development of a sophisticated test that provides a gene expression profile of a person's myeloma. (healthcentral.com)
Although researchers have made significant progress in the treatment of myeloma over the past decade, most patients will eventually relapse, meaning new therapies are in demand. (bms.com)
Multiple myeloma (MM) is a hematological malignancy characterized by a high tendency to relapse and to become drug resistant. (frontiersin.org)
However, myeloma is characterized by cycles of disease control and relapse. (newswire.ca)
Phase Ib study of isatuximab and carfilzomib in relapse and refractory multiple myeloma. (nature.com)

People with solitary plasmacytoma have a higher risk for multiple myeloma, so you'll need regular checkups. (webmd.com)
Multiple myeloma is defined as clonal bone marrow plasma cells ≥10% or biopsy-proven bony or extramedullary plasmacytoma, and one or more myeloma-defining events and biomarkers of malignancy. (medscape.com)
People with a history of a solitary plasmacytoma of the bone are at greater risk for developing multiple myeloma. (cancer.net)
Most doctors believe that plasmacytoma is simply an early, isolated form of multiple myeloma. (aaos.org)

Revised International Staging System for Multiple Myeloma: A Report From International Myeloma Working Group. (medscape.com)
The International Myeloma Working Group (IMWG) was formed by the IMF to encourage dialog and collaboration among the world's leading myeloma experts. (myeloma.org)

NEW YORK (GenomeWeb) - The Multiple Myeloma Research Foundation (MMRF) and the University of Michigan announced today that they have partnered to provide multiple myeloma patients with access to their genomic information to help guide their treatments. (genomeweb.com)
1 Recent improved understanding of the pathogenesis of myeloma has led to the development of new treatments. (bmj.com)
In addition, some of the treatments used to treat myeloma can damage the kidneys. (news-medical.net)
The MMRF relentlessly pursues innovative means that accelerate the development of next-generation multiple myeloma treatments to extend the lives of patients and lead to a cure. (volunteermatch.org)
We advocate to insure an increase in accessibility to high-quality diagnostics and treatments, for funding of myeloma-related research, and to end insurance coverage disparities for treatment. (myeloma.org)
Multiple myeloma clinical trials provide patients with exciting opportunities to be among the first to receive and benefit from promising new treatments before those options are widely available in other settings. (moffitt.org)
There are actually no treatments to cure multiple myeloma. (newsmax.com)
However, treatments are available that can help in reducing the symptoms associated with multiple myeloma. (newsmax.com)
If patients are suffering from symptoms associated with multiple myeloma, treatments can help. (newsmax.com)
One of the treatments useful for multiple myeloma patients is radiotherapy. (newsmax.com)
Some other treatments can be used to reduce symptoms associated with multiple myeloma. (newsmax.com)
Data from patients with multiple myeloma, who reported starting treatments within the last 5 years. (patientslikeme.com)
NEW ORLEANS -- Results of a cost analysis that compared multiple myeloma treatments found that treatment with bortezomib (Velcade) was associated with less out-of-pocket expenses than was treatment with the oral medications lenalidomide (Revlimid) and thalidomide (Thalomid). (medpagetoday.com)
Although there's still no cure for myeloma, various treatments are bringing about lengthy remissions, and people who were once given two to three years to live are successfully managing their condition for five to seven years, with some living a decade or longer. (harvard.edu)
The mission of the Multiple Myeloma Research Consortium (MMRC) is to champion collaboration with and integration across academia and industry and to focus on speed and innovation to bring the most promising multiple myeloma treatments to patients faster. (wikipedia.org)
We will continue to advocate, engage, support research and raise our voices for Canadians living with multiple myeloma to ensure fair and enhanced access to approved treatments in our near-future. (newswire.ca)

If you have multiple myeloma , cancerous plasma cells divide and grow inside your bone marrow. (webmd.com)
The rapid reproduction of malignant, or cancerous, myeloma cells eventually outweighs the production of healthy cells in the bone marrow. (healthline.com)
The resulting cancerous myeloma cells don't have a normal life cycle. (healthline.com)
More and more studies are showing that the gene expression profile of a cancerous tumor can help personalize treatment, and this test is the first one to be developed for multiple myeloma. (healthcentral.com)
In multiple myeloma, cancerous plasma cells accumulate in the bone marrow and crowd out healthy blood cells. (mayoclinic.org)
A cancerous or malignant plasma cell is called a myeloma cell. (myeloma.org)
One of the leading theories on the cause of multiple myeloma is that the cancerous growth of plasma cells is triggered by a DNA mutation. (thirdage.com)
Myeloma develops when plasma cells undergo a cancerous change and turn into myeloma cells. (drugs.com)

Patients must have completed a stem cell transplant regimen for newly diagnosed multiple myeloma (MM) consisting of (at least) induction chemotherapy and single or tandem autologous stem cell transplant (ASCT) within eight months of study enrollment. (clinicaltrials.gov)
To stratify patients with newly diagnosed multiple myeloma, "traditionally, we have used the International Staging System, which is predicated on serum albumin and beta-2 microglobulin," Dr Anderson continued. (medscape.com)
More than 30 years after its introduction, autologous stem cell transplantation (ASCT) remains the standard of care for young patients with newly diagnosed multiple myeloma. (nature.com)
Amrita Krishnan, MD, FACP, elucidates various combination treatment approaches making use of daratumumab in the frontline setting for patients with newly diagnosed multiple myeloma. (ajmc.com)
The researchers were able to show that the NF-kappaB pathway was activated in most of the tumor samples examined from 451 patients with newly diagnosed multiple myeloma. (nih.gov)

In most cases of multiple myeloma, the malignant plasma cells all make an identical Ig. (encyclopedia.com)

In the early stages of multiple myeloma, you might not have symptoms, or they might be very mild. (webmd.com)
During the early stages of multiple myeloma, no symptoms may be apparent. (reference.com)
Clinical trials are used for all types and stages of multiple myeloma. (cancer.net)

About 70% of individuals with multiple myeloma have soft spots or lesions in their bones. (encyclopedia.com)
These chromosome abnormalities may be an explanation for the wide variation in response to treatment among individuals with multiple myeloma. (healthcentral.com)
For individuals with multiple myeloma-those newly diagnosed to survivors of many years-and their family members and friends…all are welcome! (parknicollet.com)

Multiple myeloma is characterized by abnormalities in plasma cells, a type of white blood cell. (medlineplus.gov)
Somatic mutations, which are genetic changes that are not inherited but occur during an individual's lifetime in certain cells (in this case the plasma cells), have been identified in people with multiple myeloma. (medlineplus.gov)
Mutations in these genes may interfere with proper control (regulation) of cell growth and division (proliferation), resulting in the excessive proliferation of plasma cells that characterizes multiple myeloma. (medlineplus.gov)
Multiple myeloma is a disease in which malignant plasma cells spread through the bone marrow and hard outer portions of the large bones of the body. (encyclopedia.com)
Whereas normal bone marrow contains less than 5% plasma cells, bone marrow of an individual with multiple myeloma contains over 10% plasma cells. (encyclopedia.com)
Multiple myeloma leads to the production of too many plasma cells inside the bone marrow. (medicalnewstoday.com)
Normally, less than 5 percent of bone marrow consists of plasma cells, but in multiple myeloma, plasma cells can make up more than 10 percent of the marrow. (medicalnewstoday.com)
These cells are known as malignant plasma cells, or myeloma cells. (oncolink.org)
Multiple myeloma (MM) is a malignancy of plasma cells characterized by growth in the bone marrow (BM) environment and the development of lytic lesions in the skeleton. (springer.com)
This test can tell the difference between normal plasma cells and abnormal plasma cells (myeloma cells). (nccn.org)
In multiple myeloma, blood cells known as plasma cells start to grow out of control. (healthcentral.com)
Genetic and chromosomal tests - Specialized tests can reveal genetic or chromosomal abnormalities of the plasma cells that are usually associated with multiple myeloma. (moffitt.org)
As their number escalates, myeloma cells displace healthy ones within the bone marrow in a process that, in turn, suppresses the growth of normal plasma cells that help fight infection. (nurse.com)
A person must have >10 % clonal plasma cells and any MDE to be diagnosed with myeloma. (wikipedia.org)
Multiple myeloma (MM) is a clonal proliferation of malignant plasma cells. (unboundmedicine.com)
Plasma cells undergo multiple chromosomal mutations to progress to MM. (unboundmedicine.com)
Multiple myeloma occurs when plasma cells become abnormal and begin to divide and reproduce in an uncontrolled way. (patientslikeme.com)
Researchers are not yet sure of what causes the abnormal replication of plasma cells found in multiple myeloma patients. (thirdage.com)
In multiple myeloma, a type of white blood cell known as plasma cells multiply too rapidly in the bone marrow. (healthgrades.com)
In patients with multiple myeloma, the malignant plasma cells produce only one type of intact (whole) immunoglobulin in large amounts. (labtestsonline.org.uk)
Normally, the body makes as many plasma cells as it needs but when a person has multiple myeloma, too many plasma cells are made. (cancervic.org.au)
Multiple myeloma cells come from changed plasma cells. (aaos.org)

The 5-year survival rate for multiple myeloma is 49 percent. (medicalnewstoday.com)
In fact, a well-recognized feature of MM is the presence of an intimate relationship between PC and bone marrow microenvironment where PC are hosted in special niches and receive multiple signals that maintain their long survival and exert a protective effect on drug-induced apoptosis. (hindawi.com)
The IMF's guide through the myeloma journey, from diagnosis to long-term survival. (myeloma.org)
Mcl-1 regulates a number of processes that promote cell survival and has been implicated in resistance to anti-myeloma drugs that were initially effective. (eurekalert.org)
What is the multiple myeloma survival rate? (reference.com)
A study shows prescription drug coverage leads to better survival among Medicare beneficiaries with multiple myeloma. (cancernetwork.com)
Relapsed or refractory multiple myeloma patients experience high response rates, overall survival with bortezomib-based therapy. (cancernetwork.com)
In vitro sclerostin did not affect growth, proliferation, or survival of multiple myeloma cells. (medpagetoday.com)
They also studied the effect of sclerostin on growth and survival of multiple myeloma cells in vitro. (medpagetoday.com)
Exogenous recombinant sclerostin did not affect multiple myeloma cell viability, survival, or proliferation," Eda reported. (medpagetoday.com)
Despite its confirmed significant impact on event-free survival (EFS), multiple trials failed to depict significant impact on overall survival (OS) 9 . (nature.com)
Data predicts that there will be over a 57% increase in the number of multiple myeloma patients by 2030 as a result of achieving longer survival for these patients and the population aging. (prnewswire.com)
Multiple myeloma (MM) is a complex and heterogeneous disease [ 1 , 2 , 3 ], with variable survival. (intechopen.com)
Despite recent therapeutic advances, which have doubled the median survival time, myeloma continues to be a mostly incurable disease. (jci.org)
Continued improvement in survival in multiple myeloma: changes in early mortality and outcomes in older patients. (nature.com)

A growth factor , called interleukin-6, promotes uncontrolled growth of these myeloma cells in the bone marrow and prevents their natural death. (encyclopedia.com)
The Igs from myeloma cells are nonfunctional and are called paraproteins. (encyclopedia.com)
In addition, malignant myeloma cells produce factors that affect cells called osteoclasts. (encyclopedia.com)
Myeloma cells have more chromosomes than normal. (webmd.com)
These myeloma cells have fewer chromosomes than normal. (webmd.com)
Low immunity or recurrent infections - The spread of myeloma cells throughout the bone marrow may also cause depletion of the white blood cells, lowering immunity and leaving a patient vulnerable to infections. (news-medical.net)
Kidney damage - Myeloma cells produce an abnormal protein that can damage the kidneys as they pass from the blood and into the urine. (news-medical.net)
When a buildup of myeloma cells occurs, it can overwhelm the production of healthy cells, causing damage to the bone as well as low blood counts. (novartis.com)
When myeloma cells collect in several sites, it is called multiple myeloma. (novartis.com)
Some patients also become refractory, which means they stop responding to treatment and still have myeloma cells in their bone marrow. (novartis.com)
Because your bone marrow makes blood, multiple myeloma can affect how many healthy blood cells you have. (webmd.com)
There aren't that many myeloma cells in the body. (webmd.com)
There are more myeloma cells in the body than in stage I. (webmd.com)
Shortages of red blood cells, white blood cells, and blood platelets are common in multiple myeloma and might lead to other symptoms. (cancer.org)
These are called myeloma cells. (medicalnewstoday.com)
The abnormal myeloma cells start in the bone marrow of the spine. (medicalnewstoday.com)
In the case of MILs, the T cells targeted for harvesting are myeloma specific. (medscape.com)
Specifically, in long-term follow-up of a clinical study of MILs initiated in 2007, myeloma antigen-specific T cells were recovered from the bone marrow up to 7 years after infusion. (medscape.com)
Conversely, bone marrow biopsies conducted in those who did not achieve CR demonstrated loss of myeloma antigen-specific T cells in most cases. (medscape.com)
Research on mice also suggests that curcumin may slow the growth of multiple myeloma cells. (healthline.com)
A pathologist will view the samples under a microscope to look for myeloma cells. (nccn.org)
Flow cytometry This is a test that measures the amount of myeloma cells in the bone marrow. (nccn.org)
It is used to measure the number of myeloma cells in the bone marrow. (nccn.org)
This type of test is used to look for abnormal changes in the chromosomes of the myeloma cells. (nccn.org)
Myeloma cells can also be examined with a test called FISH. (nccn.org)
The newest testing, called gene expression , looks for certain genes that may be turned on or turned off in myeloma cells. (nccn.org)
Plasma cell proliferation This test shows what percentage of the myeloma cells are dividing. (nccn.org)
This is caused by stimulation of bone eating cells (called osteoclasts) by cytokines released from myeloma cells. (moffitt.org)
This can be caused by myeloma cells leaving little space for healthy bone marrow cells responsible for production of red blood cells or by myeloma cells releasing cytokines that suppress these cells. (moffitt.org)
In addition to these "CRAB" problems, myeloma cells can weaken the immune system and increase the risk for infections. (moffitt.org)
In addition, the unique mutations in antibody genes of myeloma cells are identified. (moffitt.org)
In the bone marrow, myeloma cells crowd out healthy blood cells, leading to fatigue and an inability to fight infections. (mayoclinic.org)
While several drugs are effective against multiple myeloma, including the proteasome inhibitor bortezomib, multiple myeloma cells are often able to survive by increasing the production of a protein known as Mcl-1. (eurekalert.org)
This research builds on our previous studies that showed exposing multiple myeloma and leukemia cells to Chk1 inhibitors activated a protective response through the Ras/MEK/ERK signaling pathway," says Pei, instructor in the Department of Internal Medicine at the VCU School of Medicine. (eurekalert.org)
In laboratory experiments, the scientists enforced overexpression of Mcl-1 in human multiple myeloma cells. (eurekalert.org)
Some myeloma cells are too immature to be caught by the drugs and thus hide underground only to reemerge later," says Keith Stewart, M.B., Ch.B., Dean for Research at Mayo Clinic in Arizona and contributor to the study. (redorbit.com)
As myeloma cells divide and increase in number, they can affect the body in various ways. (mskcc.org)
Although sclerostin stimulates the molecular cascade that leads to osteoclastogenesis, the protein has no impact on multiple myeloma cells, Eda said at this poster presentation during the annual meeting of the American Society of Hematology. (medpagetoday.com)
Myeloma cells secrete chemicals that stimulate osteoclasts (which are cells that break down bone, removing calcium). (drugs.com)
Myeloma cells also produce an abnormal type of immunoglobulin that can be detected in the blood. (drugs.com)
Myeloma cells display a promising target for immunotherapy called B-cell maturation antigen (BCMA), which is found in 60 to 70 percent of multiple myeloma patients. (bms.com)
BCMA is also used in another immunotherapy approach for myeloma called chimeric antigen receptor T-cells (CAR T) therapy. (bms.com)
An increase in the number of multiple myeloma cells crowds out the normal cells and destroys them. (rxlist.com)
The research team initially analyzed high-throughput screening assays of 7,500 genes in multiple myeloma cells to identify effectors of drug response, and then studied bone marrow biopsies from patients to further understand their results. (medindia.net)
Anti-nausea drug thalidomide when combined with turmeric can effectively kill multiple myeloma cells, say researchers. (medindia.net)
The research team's discovery began with the observation that the NF-kappaB pathway was activated in a majority of the multiple myeloma research cells they tested. (nih.gov)
Using an inhibitor of a key enzyme, named IkappaB kinase beta, needed to activate this pathway, the researchers demonstrated that these myeloma cells either died or stopped dividing when the NF-kappaB pathway was disrupted. (nih.gov)
To identify the specific genes that might be driving NF-kappaB activation in multiple myeloma, the researchers studied genes known to regulate the NF-kappaB pathway in normal cells, focusing on those with abnormally high or low expression levels in samples from patients with multiple myeloma. (nih.gov)
The Washington University Center for Multiple Myeloma Nanotherapy (WU CMMN) will address overarching questions in bone malignancies, with a focus on multiple myeloma (MM). MM is a hematopoietic disease caused by terminally differentiated malignant plasma B-cells. (cancer.gov)

To diagnose multiple myeloma, your doctor will do a combination of tests. (webmd.com)

Professor Chris Bunce, research director at Leukemia & Lymphoma Research , says this research offers more evidence that the risk of myeloma can be inherited. (medicalnewstoday.com)
The LLS mission: Cure leukemia, lymphoma, Hodgkin's disease and myeloma, and improve the quality of life of patients and their families. (lls.org)
Multiple myeloma often times originates in the bone marrow and is similar to diseases such as leukemia and lymphoma. (reference.com)
a U.S. specialty pharmaceutical company and Clinigen Group plc (AIM: CLIN, 'Clinigen') , the global pharmaceutical and services company, announce a new publication in Leukemia & Lymphoma , with study results showing that amifostine decreases gastro-intestinal (GI) toxicity in patients who receive treatment for their multiple myeloma. (prnewswire.com)

Lenalidomide, Bortezomib, and Dexamethasone With Transplantation for Myeloma. (medicinenet.com)
Panobinostat used in combination with bortezomib in relapsed multiple myeloma was shown to be superior to bortezomib alone, he explained. (medscape.com)
Eda said that the proteasome inhibitor bortezomib (Velcade) had properties that block the effects of sclerostin and that action may be one of the reasons that bortezomib therapy has been a mainstay of treatment for individuals diagnosed with multiple myeloma. (medpagetoday.com)
One year after diagnosis with multiple myeloma, the adjusted out-of-pocket costs for a patient treated with bortezomib was about $3,504, Pinsky reported. (medpagetoday.com)

These data demonstrate that increased sclerostin levels in multiple myeloma patients inhibit osteoblastogenesis and stimulate osteoclastogenesis," he suggested. (medpagetoday.com)
NEW YORK (GenomeWeb) - Researchers from Erasmus MC University Medical Center and Radboud University Medical Center in The Netherlands have developed a mass spec-based test for measuring M protein levels in multiple myeloma patients. (genomeweb.com)

Previous studies indicated that around four percent of multiple myeloma patients may have mutations in this gene, and a recent report on a single multiple myeloma patient treated with drugs targeting BRAF showed promising results. (eurekalert.org)

The cause of multiple myeloma is unknown. (wikipedia.org)

Myeloma bone disease is due to the overexpression of receptor activator for nuclear factor κ B ligand ( RANKL ) by bone marrow stroma . (wikipedia.org)
Throughout the multiple myeloma journey, a treatment team works with the patient to introduce different therapy combinations to address treatment resistance and/or disease progression. (novartis.com)
Myeloma today: Disease definitions and treatment advances. (medscape.com)
Multiple myeloma also causes kidney disease in some people. (healthline.com)
The researchers say that this latest discovery takes the number of total genetic variants linked to myeloma to seven, and may help lead to the discovery of genetic causes of the disease. (medicalnewstoday.com)
Diagnosing multiple myeloma can be tricky for your doctor, as the symptoms of this disease tend to show up in the late, rather than early, stages. (wikihow.com)
Multiple myeloma is a pretty rare disease-the average American's risk of getting at some point is just one in 132. (healthcentral.com)
The disease has no cure, but multiple myeloma treatment improves every year. (healthcentral.com)
But multiple myeloma is genetic in the sense that the genes contained in your DNA play a pretty big role in raising your risk of the disease. (healthcentral.com)
For people with multiple myeloma who require treatment, a number of options are available to help control the disease. (mayoclinic.org)
Treatment for multiple myeloma is focused on decreasing the clonal plasma cell population and consequently decrease the symptoms of disease. (wikipedia.org)
According to WebMD, risk factors that can make people more vulnerable to multiple myeloma include being male, over 65 years of age, African-American, and having family members who have been afflicted by the disease. (reference.com)
Multiple myeloma is a disease that can often be treated successfully, and many patients live long and productive lives after being diagnosed. (myeloma.org)
First-degree relatives of people with multiple myeloma have a 2- to 4-fold increased risk of developing the disease. (cancer.net)
Recent research into multiple myeloma has been very successful and oncologists say there are many promising new therapies today that treat the disease more effectively than ever before. (healthgrades.com)
Multiple myeloma symptoms can be vague and often don't occur until later in the disease. (healthgrades.com)
One of the characteristic findings in multiple myeloma is osteolytic bone disease. (medpagetoday.com)
Taken together, sclerostin may be a good target to inhibit myeloma bone disease and help restore normal bone homeostasis. (medpagetoday.com)
Early in the disease process, multiple myeloma may not cause any symptoms, and even after diagnosis, treatment may not be needed immediately. (drugs.com)
Multiple myeloma is a complex disease that places a significant burden on patients or their caregivers," said Brett Pinsky, MPH, a senior researcher at i3 Innovus, Eden Prairie, Minn., in a poster presentation at the American Society of Hematology meeting. (medpagetoday.com)
In myeloma, this is always the case due to the nature of the disease. (cancer.net)
Concomitant malignancies or previous malignancies (other than multiple myeloma) with less than a 2-year disease-free interval at the time of first dose of study drug. (pfizer.com)
It was designed to rapidly accelerate progress made against multiple myeloma by significantly improving the understanding of the biology of the disease. (wikipedia.org)
To do so, Myeloma Canada conducts frequent surveys amongst patients and caregivers in Canada to evaluate disease impact on quality of life, patient needs, treatment expectations and impact of new therapies. (newswire.ca)

Cite this: Cellular Immunotherapy for Multiple Myeloma Advancing Rapidly - Medscape - Jan 30, 2017. (medscape.com)

In this paper we discuss how the interaction between the malignant plasma cell and the BM microenvironment allowed myeloma progression through cell homing and the new concept of premetastatic niche. (hindawi.com)

You may also be susceptible to contracting infections and illnesses due to the multiple myeloma. (wikihow.com)
Multiple myeloma is discovered through routine blood screening when patients are being evaluated for other problems such as frequent infections. (rxlist.com)

Lenalidomide plus dexamethasone for relapsed multiple myeloma in North America. (nih.gov)
Lenalidomide, an oral immunomodulatory drug that is similar to thalidomide but has a different safety profile, has clinical activity in relapsed or refractory multiple myeloma. (nih.gov)
Patients in the United States and Canada who had received at least one previous therapy for multiple myeloma but who required additional treatment were randomly assigned to receive either 25 mg of lenalidomide or placebo on days 1 to 21 of a 28-day cycle. (nih.gov)
Lenalidomide plus dexamethasone is superior to placebo plus dexamethasone in patients with relapsed or refractory multiple myeloma. (nih.gov)
A phase 1b study of isatuximab plus lenalidomide and dexamethasone for relapsed/refractory multiple myeloma. (nature.com)
Daratumumab, lenalidomide, and dexamethasone for multiple myeloma. (nature.com)

In some patients, large amounts of myeloma protein can cause the blood to "thicken. (cancer.org)
During lab tests, indicators of multiple myeloma are anemia, protein in urine, elevated creatine, and high blood calcium. (reference.com)
A small study found elevated plasma levels of sclerostin, an osteocyte-secreted protein that inhibits osteoblasts and stimulates osteoclastogenesis, in patients with multiple myeloma compared with those who have other cancers or normal volunteers. (medpagetoday.com)
SAN DIEGO -- High levels of the osteocyte-secreted protein sclerostin are found in patients with multiple myeloma and that finding could give scientists a therapeutic target, researchers said here. (medpagetoday.com)
The type of myeloma a patient has is often referred to by the type of M protein or paraprotein produced, whether an intact immunoglobulin or light chain. (labtestsonline.org.uk)
If a patient has elevated protein levels, several tests are conducted, and their combined results are interpreted to make a myeloma diagnosis. (mdanderson.org)

A bone marrow biopsy can help diagnose this type of myeloma. (webmd.com)
Based off of the MRI and a bone marrow biopsy collected by the doctors who repaired my back, Dr. York was able to quickly diagnose my multiple myeloma. (healthgrades.com)

Indeed, MM PC are not able to grow in a medium without a stromal support and even PC from patients affected by refractory myeloma show drug sensitivity when cultured in vitro [ 9 ]. (hindawi.com)
A study shows comprehensive sequencing approach can identify treatment options in patients with relapsed and/or refractory myeloma. (cancernetwork.com)

Isatuximab plus pomalidomide and low-dose dexamethasone versus pomalidomide and low-dose dexamethasone in patients with relapsed and refractory multiple myeloma (ICARIA-MM): a randomised, multicentre, open-label, phase 3 study. (medscape.com)

Although the mutations that cause myeloma are acquired and not inherited, family history is a known risk factor for multiple myeloma. (cancer.net)

About one-third of people affected by multiple myeloma have no symptoms. (mskcc.org)

Noopur Raje, MD, assistant professor of medicine and director of the Center for Multiple Myeloma at Massachusetts General Hospital/Harvard Medical School said, however, that cost was often not a major factor in selection of treatment regimens for multiple myeloma. (medpagetoday.com)

Multiple myeloma is considered treatable, but generally incurable. (wikipedia.org)
Multiple myeloma remains incurable, despite the significant improvement in treatment over the past 10 years. (prnewswire.com)
Multiple Myeloma caught public attention when model turned actress Lisa Ray, who worked in Deepa Mehta's 'Water' , declared that she had the incurable Multiple Myeloma. (medindia.net)

Retrieved on June 22, 2021 from https://www.news-medical.net/health/Multiple-Myeloma-Epidemiology.aspx. (news-medical.net)
Multiple myeloma is a heterogeneous hematological malignancy in which epidemiology plays an increasingly important role. (intechopen.com)

Anemia - Either multiple myeloma itself or treatment for the condition may lower the red blood cell count and cause anemia which may lead to weakness, fatigue and shortness of breath. (news-medical.net)
Bleeding and bruising tendencies - Blood platelets, which are involved in the blood clotting process are also made in the bone marrow and multiple myeloma can lead to a depleted platelet count and an increased tendency to bruise and bleed. (news-medical.net)
Multiple myeloma can lead to too much calcium in your blood. (webmd.com)
Multiple myeloma and high levels of calcium can hurt your kidneys and make it harder for them to filter your blood. (webmd.com)
Doctors can tell what stage the multiple myeloma is in by looking at X-rays of your bones and testing your blood, pee, and bone marrow. (webmd.com)
High calcium levels in the blood can also indicate myeloma, as calcium from the bones dissolves into the bloodstream. (medicalnewstoday.com)
Anemia, or a low red blood cell count, is a common complication in people with multiple myeloma. (healthline.com)
Doctors know that myeloma begins with one abnormal plasma cell in your bone marrow - the soft, blood-producing tissue that fills in the center of most of your bones. (mayoclinic.org)
Multiple myeloma can be treated using chemotherapy and other treatment options after identification through blood tests and other diagnostic methods. (newsmax.com)
In the research, Eda and colleagues measured sclerostin concentration in the blood plasma of 20 multiple myeloma patients. (medpagetoday.com)
However, in some cases, your doctor might suspect multiple myeloma based on a blood or urine test taken for another reason. (drugs.com)
Nicotine can damage blood vessels and make it more difficult to manage your multiple myeloma. (drugs.com)
People with multiple myeloma should have regular blood tests to confirm their counts are in a safe range. (livestrong.com)
The MMRC also includes a shared tissue bank of annotated tissue and peripheral blood samples from multiple myeloma patients. (wikipedia.org)
The most common way to diagnose myeloma before symptoms appear is through routine blood work. (mdanderson.org)

Anatomy11

Organisms1

Diseases18

Chemicals and Drugs34

Analytical, Diagnostic and Therapeutic Techniques and Equipment22

Phenomena and Processes15

Information Science1

Health Care5

Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells. (1/5264)

Insertion of excised IgH switch sequences causes overexpression of cyclin D1 in a myeloma tumor cell. (2/5264)

Bone marrow angiogenesis and mast cell density increase simultaneously with progression of human multiple myeloma. (3/5264)

Detection of Kaposi's sarcoma herpesvirus DNA sequences in multiple myeloma bone marrow stromal cells. (4/5264)

Bone marrow and peripheral blood dendritic cells from patients with multiple myeloma are phenotypically and functionally normal despite the detection of Kaposi's sarcoma herpesvirus gene sequences. (5/5264)

Cell adhesion mediated drug resistance (CAM-DR): role of integrins and resistance to apoptosis in human myeloma cell lines. (6/5264)

Overexpression of the receptor for hyaluronan-mediated motility (RHAMM) characterizes the malignant clone in multiple myeloma: identification of three distinct RHAMM variants. (7/5264)

Ibandronate reduces osteolytic lesions but not tumor burden in a murine model of myeloma bone disease. (8/5264)

Multiple Myeloma

Myeloma Proteins

Boronic Acids

Pyrazines

Thalidomide

Plasma Cells

Melphalan

Paraproteinemias

Monoclonal Gammopathy of Undetermined Significance

Leukemia, Plasma Cell

Plasmacytoma

Dexamethasone

Transplantation, Autologous

Syndecan-1

Bone Marrow

Antineoplastic Agents

Cell Line, Tumor

Bence Jones Protein

Paraproteins

Immunoglobulin Light Chains

Antineoplastic Combined Chemotherapy Protocols

Proteasome Inhibitors

Hematopoietic Stem Cell Transplantation

Osteolysis

Bone Diseases

Interleukin-6

Waldenstrom Macroglobulinemia

Apoptosis

Chromosomes, Human, Pair 14

Tumor Cells, Cultured

Mice, SCID

Bone Marrow Cells

Immunoglobulin kappa-Chains

Diphosphonates

Vincristine

Syndecans

Prednisone

Prognosis

Maintenance Chemotherapy

Treatment Outcome

Immunoglobulin lambda-Chains

Antineoplastic Agents, Alkylating

Remission Induction

Stem Cell Transplantation

Drug Resistance, Neoplasm

Translocation, Genetic

Doxorubicin

Gene Expression Regulation, Neoplastic

Combined Modality Therapy

Recurrence

Survival Analysis

Survival Rate

Cyclophosphamide

Protease Inhibitors

Stromal Cells

Chromosomes, Human, Pair 13

Cell Proliferation

Hypergammaglobulinemia

beta 2-Microglobulin

Amyloidosis

Disease-Free Survival

Flow Cytometry

Bone Marrow Examination

Salvage Therapy

Disease Progression

Cell Survival

Receptors, Interleukin-6

Chromosomes, Human, Pair 4

Immunologic Factors

Receptor, Fibroblast Growth Factor, Type 3

In Situ Hybridization, Fluorescence

Immunoglobulin D

Neoplasm Proteins

Neoplasms, Plasma Cell

Drug Synergism

Chromosome Aberrations

Osteoclasts

Antibodies, Monoclonal

Xenograft Model Antitumor Assays

Immunoglobulins

$Kyprolis® Significantly Improves Overall Survival Compared To Velcade® In Relapsed Or Refractory Multiple Myeloma - UNM...$ Kyprolis® Significantly Improves Overall Survival Compared To Velcade® In Relapsed Or Refractory Multiple Myeloma - UNM...

$Paper: Overall Survival of Relapsed/Refractory Multiple Myeloma Patients Treated with Carfilzomib and Dexamethasone Vs...$ Paper: Overall Survival of Relapsed/Refractory Multiple Myeloma Patients Treated with Carfilzomib and Dexamethasone Vs...

$A Phase 1 Study of Ruxolitinib, Steroids and Lenalidomide for Relapsed/Refractory Multiple Myeloma (RRMM) Patients - Full Text...$ A Phase 1 Study of Ruxolitinib, Steroids and Lenalidomide for Relapsed/Refractory Multiple Myeloma (RRMM) Patients - Full Text...