Candidiasis, Chronic Mucocutaneous: A clinical syndrome characterized by development, usually in infancy or childhood, of a chronic, often widespread candidiasis of skin, nails, and mucous membranes. It may be secondary to one of the immunodeficiency syndromes, inherited as an autosomal recessive trait, or associated with defects in cell-mediated immunity, endocrine disorders, dental stomatitis, or malignancy.Leishmaniasis, Mucocutaneous: A disease characterized by the chronic, progressive spread of lesions from New World cutaneous leishmaniasis caused by species of the L. braziliensis complex to the nasal, pharyngeal, and buccal mucosa some time after the appearance of the initial cutaneous lesion. Nasal obstruction and epistaxis are frequent presenting symptoms.Candidiasis, Cutaneous: Candidiasis of the skin manifested as eczema-like lesions of the interdigital spaces, perleche, or chronic paronychia. (Dorland, 27th ed)Oral Ulcer: A loss of mucous substance of the mouth showing local excavation of the surface, resulting from the sloughing of inflammatory necrotic tissue. It is the result of a variety of causes, e.g., denture irritation, aphthous stomatitis (STOMATITIS, APHTHOUS); NOMA; necrotizing gingivitis (GINGIVITIS, NECROTIZING ULCERATIVE); TOOTHBRUSHING; and various irritants. (From Jablonski, Dictionary of Dentistry, 1992, p842)Leishmania braziliensis: A parasitic hemoflagellate of the subgenus Leishmania viannia that infects man and animals. It causes cutaneous (LEISHMANIASIS, CUTANEOUS), diffuse cutaneous (LEISHMANIASIS, DIFFUSE CUTANEOUS), and mucocutaneous leishmaniasis (LEISHMANIASIS, MUCOCUTANEOUS) depending on the subspecies of this organism. The sandfly, Lutzomyia, is the vector. The Leishmania braziliensis complex includes the subspecies braziliensis and peruviana. Uta, a form of cutaneous leishmaniasis in the New World, is caused by the subspecies peruviana.Mouth DiseasesPolyendocrinopathies, Autoimmune: Autoimmune diseases affecting multiple endocrine organs. Type I is characterized by childhood onset and chronic mucocutaneous candidiasis (CANDIDIASIS, CHRONIC MUCOCUTANEOUS), while type II exhibits any combination of adrenal insufficiency (ADDISON'S DISEASE), lymphocytic thyroiditis (THYROIDITIS, AUTOIMMUNE;), HYPOPARATHYROIDISM; and gonadal failure. In both types organ-specific ANTIBODIES against a variety of ENDOCRINE GLANDS have been detected. The type II syndrome differs from type I in that it is associated with HLA-A1 and B8 haplotypes, onset is usually in adulthood, and candidiasis is not present.Skin DiseasesPeutz-Jeghers Syndrome: A hereditary disease caused by autosomal dominant mutations involving CHROMOSOME 19. It is characterized by the presence of INTESTINAL POLYPS, consistently in the JEJUNUM, and mucocutaneous pigmentation with MELANIN spots of the lips, buccal MUCOSA, and digits.Lip DiseasesMucocutaneous Lymph Node Syndrome: An acute, febrile, mucocutaneous condition accompanied by swelling of cervical lymph nodes in infants and young children. The principal symptoms are fever, congestion of the ocular conjunctivae, reddening of the lips and oral cavity, protuberance of tongue papillae, and edema or erythema of the extremities.Behcet Syndrome: Rare chronic inflammatory disease involving the small blood vessels. It is of unknown etiology and characterized by mucocutaneous ulceration in the mouth and genital region and uveitis with hypopyon. The neuro-ocular form may cause blindness and death. SYNOVITIS; THROMBOPHLEBITIS; gastrointestinal ulcerations; RETINAL VASCULITIS; and OPTIC ATROPHY may occur as well.Pemphigus: Group of chronic blistering diseases characterized histologically by ACANTHOLYSIS and blister formation within the EPIDERMIS.Skin Diseases, Vascular: Skin diseases affecting or involving the cutaneous blood vessels and generally manifested as inflammation, swelling, erythema, or necrosis in the affected area.Nail Diseases: Diseases of the nail plate and tissues surrounding it. The concept is limited to primates.Eyelids: Each of the upper and lower folds of SKIN which cover the EYE when closed.Mucous Membrane: An EPITHELIUM with MUCUS-secreting cells, such as GOBLET CELLS. It forms the lining of many body cavities, such as the DIGESTIVE TRACT, the RESPIRATORY TRACT, and the reproductive tract. Mucosa, rich in blood and lymph vessels, comprises an inner epithelium, a middle layer (lamina propria) of loose CONNECTIVE TISSUE, and an outer layer (muscularis mucosae) of SMOOTH MUSCLE CELLS that separates the mucosa from submucosa.Mouth Mucosa: Lining of the ORAL CAVITY, including mucosa on the GUMS; the PALATE; the LIP; the CHEEK; floor of the mouth; and other structures. The mucosa is generally a nonkeratinized stratified squamous EPITHELIUM covering muscle, bone, or glands but can show varying degree of keratinization at specific locations.Leishmaniasis, Cutaneous: An endemic disease that is characterized by the development of single or multiple localized lesions on exposed areas of skin that typically ulcerate. The disease has been divided into Old and New World forms. Old World leishmaniasis is separated into three distinct types according to epidemiology and clinical manifestations and is caused by species of the L. tropica and L. aethiopica complexes as well as by species of the L. major genus. New World leishmaniasis, also called American leishmaniasis, occurs in South and Central America and is caused by species of the L. mexicana or L. braziliensis complexes.Leishmania: A genus of flagellate protozoa comprising several species that are pathogenic for humans. Organisms of this genus have an amastigote and a promastigote stage in their life cycles. As a result of enzymatic studies this single genus has been divided into two subgenera: Leishmania leishmania and Leishmania viannia. Species within the Leishmania leishmania subgenus include: L. aethiopica, L. arabica, L. donovani, L. enrietti, L. gerbilli, L. hertigi, L. infantum, L. major, L. mexicana, and L. tropica. The following species are those that compose the Leishmania viannia subgenus: L. braziliensis, L. guyanensis, L. lainsoni, L. naiffi, and L. shawi.Stevens-Johnson Syndrome: Rare cutaneous eruption characterized by extensive KERATINOCYTE apoptosis resulting in skin detachment with mucosal involvement. It is often provoked by the use of drugs (e.g., antibiotics and anticonvulsants) or associated with PNEUMONIA, MYCOPLASMA. It is considered a continuum of Toxic Epidermal Necrolysis.Gingival DiseasesNose Deformities, Acquired: Abnormalities of the nose acquired after birth from injury or disease.Telangiectasia, Hereditary Hemorrhagic: An autosomal dominant vascular anomaly characterized by telangiectases of the skin and mucous membranes and by recurrent gastrointestinal bleeding. This disorder is caused by mutations of a gene (on chromosome 9q3) which encodes endoglin, a membrane glycoprotein that binds TRANSFORMING GROWTH FACTOR BETA.Acitretin: An oral retinoid effective in the treatment of psoriasis. It is the major metabolite of ETRETINATE with the advantage of a much shorter half-life when compared with etretinate.Nose Diseases: Disorders of the nose, general or unspecified.Enterostomy: Creation of an artificial external opening or fistula in the intestines.Leishmania guyanensis: A parasitic hemoflagellate of the subgenus Leishmania viannia that infects man and animals and causes mucocutaneous leishmaniasis (LEISHMANIASIS, MUCOCUTANEOUS). Transmission is by Lutzomyia sandflies.Hamartoma Syndrome, Multiple: A hereditary disease characterized by multiple ectodermal, mesodermal, and endodermal nevoid and neoplastic anomalies. Facial trichilemmomas and papillomatous papules of the oral mucosa are the most characteristic lesions. Individuals with this syndrome have a high risk of BREAST CANCER; THYROID CANCER; and ENDOMETRIAL CANCER. This syndrome is associated with mutations in the gene for PTEN PHOSPHATASE.Leishmaniasis: A disease caused by any of a number of species of protozoa in the genus LEISHMANIA. There are four major clinical types of this infection: cutaneous (Old and New World) (LEISHMANIASIS, CUTANEOUS), diffuse cutaneous (LEISHMANIASIS, DIFFUSE CUTANEOUS), mucocutaneous (LEISHMANIASIS, MUCOCUTANEOUS), and visceral (LEISHMANIASIS, VISCERAL).Skin UlcerTransdermal Patch: A medicated adhesive patch placed on the skin to deliver a specific dose of medication into the bloodstream.Candida albicans: A unicellular budding fungus which is the principal pathogenic species causing CANDIDIASIS (moniliasis).Leishmaniavirus: A genus of RNA protozoan viruses of the family TOTIVIRIDAE. Several different strains of Leishmania are infected by a variety of viral species. The type species is Leishmania RNA virus 1-1.Leishmaniasis, Diffuse Cutaneous: A form of LEISHMANIASIS, CUTANEOUS caused by Leishmania aethiopica in Ethiopia and Kenya, L. pifanoi in Venezuela, L. braziliensis in South America, and L. mexicana in Central America. This disease is characterized by massive dissemination of skin lesions without visceral involvement.Antiprotozoal Agents: Substances that are destructive to protozoans.Dyskeratosis Congenita: A predominantly X-linked recessive syndrome characterized by a triad of reticular skin pigmentation, nail dystrophy and leukoplakia of mucous membranes. Oral and dental abnormalities may also be present. Complications are a predisposition to malignancy and bone marrow involvement with pancytopenia. (from Int J Paediatr Dent 2000 Dec;10(4):328-34) The X-linked form is also known as Zinsser-Cole-Engman syndrome and involves the gene which encodes a highly conserved protein called dyskerin.Acantholysis: Separation of the prickle cells of the stratum spinosum of the epidermis, resulting in atrophy of the prickle cell layer. It is seen in diseases such as pemphigus vulgaris (see PEMPHIGUS) and DARIER DISEASE.Job Syndrome: Primary immunodeficiency syndrome characterized by recurrent infections and hyperimmunoglobulinemia E. Most cases are sporadic. Of the rare familial forms, the dominantly inherited subtype has additional connective tissue, dental and skeletal involvement that the recessive type does not share.Entropion: The turning inward (inversion) of the edge of the eyelid, with the tarsal cartilage turned inward toward the eyeball. (Dorland, 27th ed)Dermatomycoses: Superficial infections of the skin or its appendages by any of various fungi.Herpes Simplex: A group of acute infections caused by herpes simplex virus type 1 or type 2 that is characterized by the development of one or more small fluid-filled vesicles with a raised erythematous base on the skin or mucous membrane. It occurs as a primary infection or recurs due to a reactivation of a latent infection. (Dorland, 27th ed.)Lichen Planus, Oral: Oral lesions accompanying cutaneous lichen planus or often occurring alone. The buccal mucosa, lips, gingivae, floor of the mouth, and palate are usually affected (in a descending order of frequency). Typically, oral lesions consist of radiating white or gray, velvety, threadlike lines, arranged in a reticular pattern, at the intersection of which there may be minute, white, elevated dots or streaks (Wickham's striae). (Jablonski, Illustrated Dictionary of Dentistry)Dermatitis: Any inflammation of the skin.Maternal-Child Health Centers: Facilities which administer the delivery of health care services to mothers and children.Stomatitis, Herpetic: Stomatitis caused by Herpesvirus hominis. It usually occurs as acute herpetic stomatitis (or gingivostomatitis), an oral manifestation of primary herpes simplex seen primarily in children and adolescents.Acyclovir: A GUANOSINE analog that acts as an antimetabolite. Viruses are especially susceptible. Used especially against herpes.Meglumine: 1-Deoxy-1-(methylamino)-D-glucitol. A derivative of sorbitol in which the hydroxyl group in position 1 is replaced by a methylamino group. Often used in conjunction with iodinated organic compounds as contrast medium.Ecthyma: An ulcerative pyoderma usually caused by group A beta-hemolytic streptococcal infection at the site of minor trauma. (Dorland, 27th ed)Skin Diseases, Vesiculobullous: Skin diseases characterized by local or general distributions of blisters. They are classified according to the site and mode of blister formation. Lesions can appear spontaneously or be precipitated by infection, trauma, or sunlight. Etiologies include immunologic and genetic factors. (From Scientific American Medicine, 1990)Erythema Multiforme: A skin and mucous membrane disease characterized by an eruption of macules, papules, nodules, vesicles, and/or bullae with characteristic "bull's-eye" lesions usually occurring on the dorsal aspect of the hands and forearms.Drug Eruptions: Adverse cutaneous reactions caused by ingestion, parenteral use, or local application of a drug. These may assume various morphologic patterns and produce various types of lesions.Candidiasis: Infection with a fungus of the genus CANDIDA. It is usually a superficial infection of the moist areas of the body and is generally caused by CANDIDA ALBICANS. (Dorland, 27th ed)Coagulation Protein Disorders: Hemorrhagic and thrombotic disorders resulting from abnormalities or deficiencies of coagulation proteins.AIDS-Related Opportunistic Infections: Opportunistic infections found in patients who test positive for human immunodeficiency virus (HIV). The most common include PNEUMOCYSTIS PNEUMONIA, Kaposi's sarcoma, cryptosporidiosis, herpes simplex, toxoplasmosis, cryptococcosis, and infections with Mycobacterium avium complex, Microsporidium, and Cytomegalovirus.Lichen Planus: An inflammatory, pruritic disease of the skin and mucous membranes, which can be either generalized or localized. It is characterized by distinctive purplish, flat-topped papules having a predilection for the trunk and flexor surfaces. The lesions may be discrete or coalesce to form plaques. Histologically, there is a "saw-tooth" pattern of epidermal hyperplasia and vacuolar alteration of the basal layer of the epidermis along with an intense upper dermal inflammatory infiltrate composed predominantly of T-cells. Etiology is unknown.Desmoglein 3: A desmosomal cadherin that is an autoantigen in the acquired skin disorder PEMPHIGUS VULGARIS.Conjunctiva: The mucous membrane that covers the posterior surface of the eyelids and the anterior pericorneal surface of the eyeball.Fatal Outcome: Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.Paraneoplastic Syndromes: In patients with neoplastic diseases a wide variety of clinical pictures which are indirect and usually remote effects produced by tumor cell metabolites or other products.Candidiasis, Oral: Infection of the mucous membranes of the mouth by a fungus of the genus CANDIDA. (Dorland, 27th ed)Skin: The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.Blood Platelet Disorders: Disorders caused by abnormalities in platelet count or function.Histoplasmosis: Infection resulting from inhalation or ingestion of spores of the fungus of the genus HISTOPLASMA, species H. capsulatum. It is worldwide in distribution and particularly common in the midwestern United States. (From Dorland, 27th ed)Foscarnet: An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV.Herpesvirus 2, Human: A species of SIMPLEXVIRUS associated with genital infections (HERPES GENITALIS). It is transmitted by sexual intercourse and close personal contact.Herpes Genitalis: Infection of the genitals (GENITALIA) with HERPES SIMPLEX VIRUS in either the males or the females.Interleukin-17: A proinflammatory cytokine produced primarily by T-LYMPHOCYTES or their precursors. Several subtypes of interleukin-17 have been identified, each of which is a product of a unique gene.Thrombasthenia: A congenital bleeding disorder with prolonged bleeding time, absence of aggregation of platelets in response to most agents, especially ADP, and impaired or absent clot retraction. Platelet membranes are deficient in or have a defect in the glycoprotein IIb-IIIa complex (PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX).Codon, Nonsense: An amino acid-specifying codon that has been converted to a stop codon (CODON, TERMINATOR) by mutation. Its occurance is abnormal causing premature termination of protein translation and results in production of truncated and non-functional proteins. A nonsense mutation is one that converts an amino acid-specific codon to a stop codon.Skin Tests: Epicutaneous or intradermal application of a sensitizer for demonstration of either delayed or immediate hypersensitivity. Used in diagnosis of hypersensitivity or as a test for cellular immunity.Autoantibodies: Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them.Syndrome: A characteristic symptom complex.Papilloma: A circumscribed benign epithelial tumor projecting from the surrounding surface; more precisely, a benign epithelial neoplasm consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic cells. (Stedman, 25th ed)Sarcoma, Kaposi: A multicentric, malignant neoplastic vascular proliferation characterized by the development of bluish-red cutaneous nodules, usually on the lower extremities, most often on the toes or feet, and slowly increasing in size and number and spreading to more proximal areas. The tumors have endothelium-lined channels and vascular spaces admixed with variably sized aggregates of spindle-shaped cells, and often remain confined to the skin and subcutaneous tissue, but widespread visceral involvement may occur. Kaposi's sarcoma occurs spontaneously in Jewish and Italian males in Europe and the United States. An aggressive variant in young children is endemic in some areas of Africa. A third form occurs in about 0.04% of kidney transplant patients. There is also a high incidence in AIDS patients. (From Dorland, 27th ed & Holland et al., Cancer Medicine, 3d ed, pp2105-7) HHV-8 is the suspected cause.Acquired Immunodeficiency Syndrome: An acquired defect of cellular immunity associated with infection by the human immunodeficiency virus (HIV), a CD4-positive T-lymphocyte count under 200 cells/microliter or less than 14% of total lymphocytes, and increased susceptibility to opportunistic infections and malignant neoplasms. Clinical manifestations also include emaciation (wasting) and dementia. These elements reflect criteria for AIDS as defined by the CDC in 1993.Pedigree: The record of descent or ancestry, particularly of a particular condition or trait, indicating individual family members, their relationships, and their status with respect to the trait or condition.Genes, Dominant: Genes that influence the PHENOTYPE both in the homozygous and the heterozygous state.STAT1 Transcription Factor: A signal transducer and activator of transcription that mediates cellular responses to INTERFERONS. Stat1 interacts with P53 TUMOR SUPPRESSOR PROTEIN and regulates expression of GENES involved in growth control and APOPTOSIS.Antigens, Protozoan: Any part or derivative of any protozoan that elicits immunity; malaria (Plasmodium) and trypanosome antigens are presently the most frequently encountered.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Bromodeoxyuridine: A nucleoside that substitutes for thymidine in DNA and thus acts as an antimetabolite. It causes breaks in chromosomes and has been proposed as an antiviral and antineoplastic agent. It has been given orphan drug status for use in the treatment of primary brain tumors.Interleukins: Soluble factors which stimulate growth-related activities of leukocytes as well as other cell types. They enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli.Polymerase Chain Reaction: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Keratinocytes: Epidermal cells which synthesize keratin and undergo characteristic changes as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell.Herpesvirus 1, Human: The type species of SIMPLEXVIRUS causing most forms of non-genital herpes simplex in humans. Primary infection occurs mainly in infants and young children and then the virus becomes latent in the dorsal root ganglion. It then is periodically reactivated throughout life causing mostly benign conditions.Antiviral Agents: Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.Skin Neoplasms: Tumors or cancer of the SKIN.Phenotype: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.Lupus Erythematosus, Systemic: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.Mutation, Missense: A mutation in which a codon is mutated to one directing the incorporation of a different amino acid. This substitution may result in an inactive or unstable product. (From A Dictionary of Genetics, King & Stansfield, 5th ed)Biopsy: Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.Antifungal Agents: Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.Simplexvirus: A genus of the family HERPESVIRIDAE, subfamily ALPHAHERPESVIRINAE, consisting of herpes simplex-like viruses. The type species is HERPESVIRUS 1, HUMAN.Genetic Predisposition to Disease: A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.Interferon-gamma: The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.HIV Infections: Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).Recurrence: The return of a sign, symptom, or disease after a remission.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Prevalence: The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.DNA Mutational Analysis: Biochemical identification of mutational changes in a nucleotide sequence.Cell Count: The number of CELLS of a specific kind, usually measured per unit volume or area of sample.Cytokines: Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
Mucocutaneous dysfunctions of paraneoplastic syndromes can be seen in cases of itching (hypereosinophilia), immune system ... The following diseases manifest by means of mucocutaneous dysfunction: acanthosis nigricans, dermatomyositis, Leser-Trélat sign ... Cohen PR, Kurzrock R (1997). "Mucocutaneous paraneoplastic syndromes". Semin. Oncol. 24 (3): 334-59. PMID 9208889. Hill, ... mucocutaneous, and hematological. The most common presentation is a fever (release of endogenous pyrogens often related to ...
1993 May;28(5 Pt 1):775-7. Mucocutaneous reactions to chemotherapy. Susser WS, Whitaker-Worth DL, Grant-Kels JM. J Am Acad ...
Hemoflagellates: Cutaneous and Mucocutaneous Leishmaniasis. In: Barron's Medical Microbiology (4th ed.). Univ of Texas Medical ...
Mucocutaneous lesions can be present. Common findings include oral ulcers that come and go. In some cases, these ulcers are ... Patients can also present with mucocutaneous lesions, as well as psoriasis-like skin lesions such as circinate balanitis, and ... often with additional mucocutaneous lesions), which at that time was also referred to as Fiessenger-Leroy-Reiter syndrome. ...
A vesiculobullous disease is a type of mucocutaneous disease characterized by vesicles and bullae (i.e. blisters). Both ... Williams DM (December 1989). "Vesiculobullous mucocutaneous disease: pemphigus vulgaris". J. Oral Pathol. Med. 18 (10): 544-53 ...
... braziliensis causes mucocutaneous leishmaniasis. L. tropica causes cutaneous leishmaniasis. L. peruviana and L. major cause ...
The mucocutaneous end-organs are formed after birth, with few in newborn infants and many well-organized endings in adults. ... These zones are apparently mucocutaneous skin. The rete ridges of the epithelium are well-formed and more of the nerves are ... The foreskin, which carries the highly innervated ridged band and lower frenular delta, has mucocutaneous end-organs extending ...
... familial chronic mucocutaneous, autosomal dominant; 613108; CLEC7A Candidiasis, familial chronic mucocutaneous, autosomal ...
This includes visceral, mucocutaneous, and cutaneous leishmaniasis. It is given by injection into a muscle or into the area ...
An autoimmune mucocutaneous disease associated with neoplasia". The New England Journal of Medicine. 323 (25): 1729-35. doi: ...
Pruritus, gout, and mucocutaneous bleeding are occasionally seen. The cause of CNL is currently unknown. An association between ...
October 2009). "Human dectin-1 deficiency and mucocutaneous fungal infections". The New England Journal of Medicine. 361 (18): ... changes in the occurrence of TLR4 polymorphisms Deficiency of dectin-1 leads to increased susceptibility to mucocutaneous ...
Defective Th1 and Th17 immune responses leading to chronic mucocutaneous candidiasis result from a mutation further downstream ... "STAT1 mutations in autosomal dominant chronic mucocutaneous candidiasis". N. Engl. J. Med. 365 (1): 54-61. doi:10.1056/ ...
The epithelium of the glans penis is mucocutaneous tissue. Birley et al. report that excessive washing with soap may dry the ...
Mucocutaneous leishmaniasis is an especially disturbing form of cutaneous leishmaniasis, because it produces destructive and ... Recent studies from Bolivia show a high cure rate for mucocutaneous leishmaniasis. Comparative studies against pentavalent ... Mucocutaneous leishmaniasis is very difficult to treat. Treatment involves the use of pentavalent antimonial compounds, which ... especially as destructive mucocutaneous lesions). Lesions of other Leishmania species may spontaneously heal and then reappear ...
Ives, A., et al., Leishmania RNA virus controls the severity of mucocutaneous leishmaniasis. Science, 2011. 331(6018): p. 775. ...
Internal urethral orifice Mucosa Mucocutaneous boundary Meatus Body cavity. ...
Rhodes, Arthur R.; Silverman, Robert A.; Harrist, Terence J.; Perez-Atayde, Antonio R. (1984). "Mucocutaneous lentigines, ... muco-cutaneous myxomas, and blue naevi) syndrome, NAME (nevi, atrial myxoma, myxoid neurofibromas, and ephelides) syndrome and ...
The highly innervated mucocutaneous zone of the penis occurs near the tip of the foreskin. The foreskin is mobile, fairly ... The mucocutaneous zone occurs where the outer and inner foreskin meet. The ridged band of highly innervated tissue is located ... Dorsal slit Erogenous zone Foreskin restoration Holy Prepuce Kynodesme Mucocutaneous zone Preputial mucosa Sex organ "Phimosis ...
Accompanying symptoms fever, chest pain, coughing, purulent sputum, mucocutaneous bleeding, jaundice. Imaging examination chest ...
The most common side effects are mucocutaneous: dry lips, skin and nose. Other common mucocutaneous side effects are ...
... pemphigus vulgaris is characterized by extensive flaccid blisters and mucocutaneous erosions. The severity of the disease, as ...
Keren G, Danon YL, Orgad S, Kalt R, Gazit E (August 1982). "HLA Bw51 is increased in mucocutaneous lymph node syndrome in ... Bw51 was associated with Behçet's disease, in endemic (versus epidemic) mucocutaneous lymph node syndrome, susceptibility to ...
... mucocutaneous markers of an underlying gastric malignancy". J Clin Oncol. 31 (13): e218-9. doi:10.1200/JCO.2012.45.2151. PMID ...
Stage II: include minor mucocutaneous manifestations and recurrent upper respiratory tract infections. Stage III: includes ...
Compare risks and benefits of common medications used for Chronic Mucocutaneous Candidiasis. Find the most popular drugs, view ... Home › Drugs by Condition › Fungal Infections › Cutaneous Fungal Infection › Chronic Mucocutaneous Candidiasis ... What is Chronic Mucocutaneous Candidiasis: A group of disorders characterised by infections of the skin, nails and mucous ... Looking for answers? Ask a question or go join the chronic mucocutaneous candidiasis support group to connect with others who ...
... chronic mucocutaneous candidiasis (CMC) with a signal transducer and activator of transcription (STAT) 1 gene mutation, and ... Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity. Science. 2011;332:65-8.PubMed ... STAT1 mutations in autosomal dominant chronic mucocutaneous candidiasis. N Engl J Med. 2011;365:54-61.PubMedCrossRefGoogle ... Autosomal-Dominant Chronic Mucocutaneous Candidiasis with STAT1-Mutation can be Complicated with Chronic Active Hepatitis and ...
Mucocutaneous lymph node syndrome (Kawasaki disease): report of case with atypical features. The Journal of the American ... Mucocutaneous lymph node syndrome (Kawasaki disease): report of case with atypical features. J Am Osteopath Assoc 1979;79(1):82 ... Mucocutaneous lymph node syndrome (Kawasaki disease): report of case with atypical features ... Mucocutaneous lymph node syndrome (Kawasaki disease): report of case with atypical features ...
I live on Long Island, NY and I am wondering if anyone knows an immune specialist near me who treats chronic mucocutaneous ...
... is caused by white blood cells poor function, which ... One Response to "Chronic Mucocutaneous Candidiasis". * arianne. Says: March 10th, 2011 at 6:21 pm I have the disease and trust ... Chronic Mucocutaneous Candidiasis is most likely to occur in girls than in boys, and the severity of the disease varies. Some ... Although the Chronic Mucocutaneous Candidiasis is usually uncurable, transplantation of bone marrow is succesful in a single ...
We describe a large family in which a combination of chronic mucocutaneous candidiasis (fungal infections of the skin, nails, ... An immune defect causing dominant chronic mucocutaneous candidiasis and thyroid disease maps to chromosome 2p in a single ... This is the first linkage assignment of a dominant locus for mucocutaneous candidiasis. ...
Chronic mucocutaneous candidiasis (CMC) is usually the first and the most common symptom of APECED. Therefore, the immune ... chronic mucocutaneous candidiasis, and additional ectodermal disorders.. ...
Weston WL, Huff JC: The mucocutaneous lymph node syndrome: a critical re-examination. Clin Exp Dermatol. 1981, 6: 167-178. ... Kawasaki T: Acute febrile mucocutaneous syndrome with lymphoid involvement with specific desquamation of the fingers and toes ...
... and toxic epidermal necrolysis are severe, life-threatening mucocutaneous adverse drug reactions with ...
... mucocutaneous telangiectasia, and repeated nasal bleeding due to vascular abnormalities. Hereditary haemorrhagic telangiectasia ...
... all had chronic mucocutaneous candidiasis with demonstrated antibody reactivity to candida enolase, which is suggestive of ...
A mucocutaneous zone, or mucocutaneous boundary is a region of the body in which mucosa transitions to skin. Mucocutaneous ... A mucocutaneous zone is often the site of an arterial anastomosis, a watershed area of venous and lymphatic drainage, and ... In humans, mucocutaneous zones are found at the lips, nostrils, conjunctivae, urethra, vagina (in females), foreskin (in males ... At a mucocutaneous junction, epithelium transitions to epidermis, lamina propria transitions to dermis, and smooth muscle ...
"Orphanet: Chronic mucocutaneous candidiasis". www.orpha.net. Retrieved 2017-06-09. "Familial chronic mucocutaneous candidiasis ... Chronic mucocutaneous candidiasis is an immune disorder of T cells, it is characterized by chronic infections with Candida that ... "Chronic Mucocutaneous Candidiasis: Background, Pathophysiology, Epidemiology". Medscape. 3 May 2017. Retrieved 8 June 2017. ... ISBN 0-7216-2921-0. "Candidiasis familial chronic mucocutaneous, autosomal recessive , Genetic and Rare Diseases Information ...
Chronic mucocutaneous candidiasis (CMC) refers to a heterogeneous group of disorders characterized by recurrent or persistent ... encoded search term (Chronic Mucocutaneous Candidiasis) and Chronic Mucocutaneous Candidiasis What to Read Next on Medscape. ... Chronic Mucocutaneous Candidiasis. Updated: Apr 17, 2017 * Author: Blanca Anais Estupiñan; Chief Editor: Dirk M Elston, MD more ... Chronic mucocutaneous candidiasis (CMC) is associated with a defect in cell-mediated immunity that may either be limited to ...
Mucocutaneous fungal infections are typically found in patients who have no known immune defects. We describe a family in which ... Human dectin-1 deficiency and mucocutaneous fungal infections.. Ferwerda B1, Ferwerda G, Plantinga TS, Willment JA, van Spriel ... Dectin-1 deficiency and mucocutaneous fungal infections. [N Engl J Med. 2010] ...
The report analyzes and presents an overview of Mucocutaneous Lymph Node Syndrome (Kawasaki Disease) Global Clinical Trials ... Global Mucocutaneous Lymph Node Syndrome (Kawasaki Disease) Clinical Trials Review, H2, 2016. Press Release • Oct 18, 2016 06: ... This report provides top line data relating to the clinical trials on Mucocutaneous Lymph Node Syndrome (Kawasaki Disease). ... semiconductorspharmaceuticalsmedical sciencemarket research reportsequipmentchemicalssyndromenodelymphmucocutaneous ...
In 16 patients with mucocutaneous lymphnode syndrome (MCLS) during the first 2 weeks after the onset (acute phase) and 1 month ... Mucocutaneous lymphnode syndrome (MCLS) Kawasaki disease-Circulating immune complex (CIC) This is a preview of subscription ... Fossard C, Thompson RA (1977) Mucocutaneous lymph-node syndrome (Kawasaki disease): probable-complex disorder. Brit Med J I:883 ... In 16 patients with mucocutaneous lymphnode syndrome (MCLS) during the first 2 weeks after the onset (acute phase) and 1 month ...
We describe a case of fatal systemic amyloidosis presenting with mucocutaneous bullous lesions in a patient with IgA κ ... Mucocutaneous bullous amyloidosis with an unusual mixed protein composition of amyloid deposits ...
mucocutaneous junction. Answers To Your Questions About Your Young Sons Intact Penis. January 17, 2011 From the National ...
The aim of this study was to evaluate the risks and benefits of a temporary mucocutaneous TC.. METHODS: 83 patients (56 males, ... Temporary Mucocutaneous Transverse Colostomy: Technical Approach.. INTRODUCTION: Transverse colostomy (TC) is a surgical ...
Review of Mucocutaneous Paraneoplastic Syndromes. TABLE 2. Mucocutaneous Paraneoplastic Syndromes Associated With Hematologicc ... Mucocutaneous Paraneoplastic Syndromes Associated With Hematologic Malignancies. October 15, 2011. Heather A. Steele, MD, ... Mucocutaneous paraneoplastic syndromes can occur before, after, or at the time of the cancer diagnosis; they can also be ... Mucocutaneous paraneoplastic syndromes (MCPS). A clinical-pathologic review. J Exp Clin Cancer Res. 1998;17:453-64. ...
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Mucocutaneous lymph node disease synonyms, Mucocutaneous lymph node disease pronunciation, Mucocutaneous lymph node disease ... translation, English dictionary definition of Mucocutaneous lymph node disease. Noun 1. Kawasaki disease - an acute disease of ... young children characterized by a rash and swollen lymph nodes and fever; of unknown cause mucocutaneous... ... redirected from Mucocutaneous lymph node disease). Also found in: Thesaurus, Medical.. Related to Mucocutaneous lymph node ...
1 Immune Response in Amphotericin B-Treated Mucocutaneous Leishmaniasis," Journal of Biomedicine and Biotechnology, vol. 2007, ... 1 Immune Response in Amphotericin B-Treated Mucocutaneous Leishmaniasis. Washington R. Cuna, Rianed Velasquez, Janeth Riva, ...
A New Infantile Acute Febrile Mucocutaneous Lymph Node Syndrome (MLNS) Prevailing in Japan. Tomisaku Kawasaki, Fumio Kosaki, ... It is an acute, febrile, mucocutaneous condition accompanied by swelling of cervical lymph nodes (tentatively called ... A New Infantile Acute Febrile Mucocutaneous Lymph Node Syndrome (MLNS) Prevailing in Japan ... A New Infantile Acute Febrile Mucocutaneous Lymph Node Syndrome (MLNS) Prevailing in Japan ...
  • Certain Leishmania species (L. braziliensis, L. major, L. panamensis, L. guyanensis, L. infantum, and L. donovani) are known for their propensity to produce mucocutaneous forms that start with the development of an erythematous papule at the site of the sand fly bite . (symptoma.com)
  • Dog showing mucocutaneous lesion caused by Leishmania tropica before treatment. (biomedcentral.com)
  • Inborn errors of mucocutaneous immunity to Candida albicans in humans: a role for IL-17 cytokines? (nih.gov)
  • More rarely, CMC results from inborn errors of immunity, the recent dissection of which has shed light on the molecular mechanisms of mucocutaneous immunity to Candida albicans. (nih.gov)
  • Mucocutaneous diseases are more frequent in HIV/AIDS-infected children than in the normal population. (ovid.com)
  • A mucocutaneous zone, or mucocutaneous boundary is a region of the body in which mucosa transitions to skin. (wikipedia.org)