High molecular weight mucoproteins that protect the surface of EPITHELIAL CELLS by providing a barrier to particulate matter and microorganisms. Membrane-anchored mucins may have additional roles concerned with protein interactions at the cell surface.
Mucins that are found on the surface of the gastric epithelium. They play a role in protecting the epithelial layer from mechanical and chemical damage.
A gel-forming mucin that is predominantly expressed by submucosal glands of airway tissues and the SUBLINGUAL GLAND. It is one of the principal components of high molecular weight salivary mucin.
Carbohydrate antigen elevated in patients with tumors of the breast, ovary, lung, and prostate as well as other disorders. The mucin is expressed normally by most glandular epithelia but shows particularly increased expression in the breast at lactation and in malignancy. It is thus an established serum marker for breast cancer.
A transmembrane mucin that is found in a broad variety of epithelial tissue. Mucin-4 may play a role in regulating cellular adhesion and in cell surface signaling from the ERBB-2 RECEPTOR PROTEIN-TYROSINE KINASE. Mucin-4 is a heterodimer of alpha and beta chains. The alpha and beta chains result from the proteolytic cleavage of a precursor protein.
A membrane-bound mucin subtype that is primarily found in INTESTINAL MUCOSA. Two closely-related subtypes of this protein have been identified in humans.
A gel-forming mucin that is predominantly associated with the gastric epithelium.
A glandular epithelial cell or a unicellular gland. Goblet cells secrete MUCUS. They are scattered in the epithelial linings of many organs, especially the SMALL INTESTINE and the RESPIRATORY TRACT.
The viscous secretion of mucous membranes. It contains mucin, white blood cells, water, inorganic salts, and exfoliated cells.
A subcategory of mucins that contain SIALIC ACID.
The chemical or biochemical addition of carbohydrate or glycosyl groups to other chemicals, especially peptides or proteins. Glycosyl transferases are used in this biochemical reaction.
Carbohydrate antigens expressed by malignant tissue. They are useful as tumor markers and are measured in the serum by means of a radioimmunoassay employing monoclonal antibodies.
Carbohydrates consisting of between two (DISACCHARIDES) and ten MONOSACCHARIDES connected by either an alpha- or beta-glycosidic link. They are found throughout nature in both the free and bound form.
The cartilaginous and membranous tube descending from the larynx and branching into the right and left main bronchi.
A histochemical technique for staining carbohydrates. It is based on PERIODIC ACID oxidation of a substance containing adjacent hydroxyl groups. The resulting aldehydes react with Schiff reagent to form a colored product.
The largest class of organic compounds, including STARCH; GLYCOGEN; CELLULOSE; POLYSACCHARIDES; and simple MONOSACCHARIDES. Carbohydrates are composed of carbon, hydrogen, and oxygen in a ratio of Cn(H2O)n.
Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI.
The sequence of carbohydrates within POLYSACCHARIDES; GLYCOPROTEINS; and GLYCOLIPIDS.
The mucous membrane that covers the posterior surface of the eyelids and the anterior pericorneal surface of the eyeball.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
A biomineral consisting of layers of crystalized ARAGONITE, separated by interlamellar layers of organic matrix containing beta-CHITIN, and surrounded by an intercrystalline organic membrane of silk fibroin. Nacre is the iridescent substance better known as mother-of-pearl that is secreted by MOLLUSCS.
The application of LUBRICANTS to diminish FRICTION between two surfaces.
A plant genus of the family Orobanchaceae that is parasitic on the roots of other plants. Members contain the flavones, APIGENIN and LUTEOLIN.
A genus of pearl oysters in the family Pteriidae, class BIVALVIA. Both cultured and natural pearls are obtained from species in the genus. They are distinct from the distantly related, edible true oysters of the family OSTREIDAE.

Complete sequence of the human mucin MUC4: a putative cell membrane-associated mucin. (1/2610)

The MUC4 gene, which encodes a human epithelial mucin, is expressed in various epithelial tissues, just as well in adult as in poorly differentiated cells in the embryo and fetus. Its N-terminus and central sequences have previously been reported as comprising a 27-residue peptide signal, followed by a large domain varying in length from 3285 to 7285 amino acid residues. The present study establishes the whole coding sequence of MUC4 in which the C-terminus is 1156 amino acid residues long and shares a high degree of similarity with the rat sialomucin complex (SMC). SMC is a heterodimeric glycoprotein complex composed of mucin (ascites sialoglycoprotein 1, ASGP-1) and transmembrane (ASGP-2) subunits. The same organization is found in MUC4, where the presence of a GlyAspProHis proteolytic site may cleave the large precursor into two subunits, MUC4alpha and MUC4beta. Like ASGP-2, which binds the receptor tyrosine kinase p185(neu), MUC4beta possesses two epidermal growth factor-like domains, a transmembrane sequence and a potential phosphorylated site. MUC4, the human homologue of rat SMC, may be a heterodimeric bifunctional cell-surface glycoprotein of 2.12 micrometers. These results confer a new biological role for MUC4 as a ligand for ErbB2 in cell signalling.  (+info)

Role of retinoid receptors in the regulation of mucin gene expression by retinoic acid in human tracheobronchial epithelial cells. (2/2610)

To investigate which retinoid receptors are critical in the regulation by all-trans-retinoic acid (RA) of the mucin genes MUC2, MUC5AC and MUC5B in cultured normal human tracheobronchial epithelial (NHTBE) cells, we used pan-RAR-, pan-RXR- and RAR- isotype (alpha, beta and gamma)-selective agonists and RARalpha- and RARgamma-selective antagonists (RAR is RA receptor and RXR is retinoid X receptor). RAR-, RARalpha- and RARgamma-selective agonists strongly induced mucin mRNAs in a dose-dependent manner, while the RARbeta-selective retinoid only weakly induced mucin gene expression at very high concentrations (1 microM). The pan-RXR-selective agonist by itself did not induce mucin gene expression, but acted synergistically with suboptimal concentrations of the pan-RAR agonist. A retinoid with selective anti-activator-protein-1 activity only marginally induced mucin gene expression. The RARalpha antagonist strongly inhibited mucin gene induction and mucous cell differentiation caused by RA and by the RARalpha- and RARgamma-selective retinoids. In contrast, the RARgamma antagonist only weakly inhibited RARalpha-selective-retinoid-induced mucin gene expression, but completely blocked mucin gene expression induced by the RARgamma-selective retinoid. Our studies indicate that RARalpha is the major retinoid receptor subtype mediating RA-dependent mucin gene expression and mucous cell differentiation, but that the RARgamma isotype can also induce mucin genes. Furthermore these studies suggest that RARbeta is probably not (directly) involved in RA-induced mucin gene expression.  (+info)

Physical characterization of a low-charge glycoform of the MUC5B mucin comprising the gel-phase of an asthmatic respiratory mucous plug. (3/2610)

We have previously noted that sequential extraction of an asthmatic mucous exudate with 6 M guanidinium chloride yielded a fraction of the mucins that were most resistant to solubilization and of high Mr [Sheehan, Richardson, Fung, Howard and Thornton (1995) Am. J. Respir. Cell Mol. Biol. 13, 748-756]. Here we show that this mucin fraction is dominated (at least 96% of the total) by the low-charge glycoform of the MUC5B gene product. Seen in the electron microscope the mucins appeared mainly as compact 'island' structures composed of linear threads often emanating from globular 'nodes' rather than the discrete linear threads more typical of mucins that we have previously described. The effect of reducing agents was as expected for other gel-forming mucins, i.e. reduced subunits or monomers of Mr 3x10(6)) were produced within 15 min of treatment. Kinetic experiments on the cleavage of the intact mucins with the proteinase trypsin indicated two clear regimes of fragmentation. An initial rapid cleavage generated mucins ranging from Mr=4x10(6) to 30x10(6) that in the electron microscope appeared as polydisperse threads (500-3000 nm in length), similar to normal and other respiratory mucins that we have previously characterized. A subsequent slower fragmentation over many hours yielded a major fragment of Mr 3x10(6) and length 200-600 nm, very similar in size and Mr to the subunits obtained by reduction. The results suggest that the MUC5B mucin is assembled, first into polydisperse linear threads, which are then linked together via a protein-mediated process. This might involve part of the mucin polypeptide or an as yet unidentified protein(s). The high proteinase susceptibility of the linkage suggests that it might be a point of control for mucin size and thus mucus rheology.  (+info)

Salivary mucin MG1 is comprised almost entirely of different glycosylated forms of the MUC5B gene product. (4/2610)

The MG1 population of mucins was isolated from human whole salivas by gel chromatography followed by isopycnic density gradient centrifugation. The reduced and alkylated MG1 mucins, separated by anion exchange chromatography, were of similar size (radius of gyration 55-64 nm) and molecular weight (2.5-2.9 x 10(6) Da). Two differently-charged populations of MG1 subunits were observed which showed different reactivity with monoclonal antibodies to glycan epitopes. Monosaccharide and amino acid compositional analyses indicated that the MG1 subunits had similar glycan structures on the same polypeptide. An antiserum recognizing the MUC5B mucin was reactive across the entire distribution, whereas antisera raised against the MUC2 and MUC5AC mucins showed no reactivity. Western blots of agarose gel electrophoresis of fractions across the anion exchange distribution indicated that the polypeptide underlying the mucins was the product of the MUC5B gene. Amino acid analysis and peptide mapping performed on the fragments produced by trypsin digestion of the two MG1 populations yielded data similar to that obtained for MUC5B mucin subunits prepared from respiratory mucus (Thornton et al., 1997) and confirmed that the MUC5B gene product was the predominant mucin polypeptide present. Isolation of the MG1 mucins from the secretions of the individual salivary glands (palatal, sublingual, and submandibular) indicate that the palatal gland is the source of the highly charged population of the MUC5B mucin.  (+info)

The sialylation of bronchial mucins secreted by patients suffering from cystic fibrosis or from chronic bronchitis is related to the severity of airway infection. (5/2610)

Bronchial mucins were purified from the sputum of 14 patients suffering from cystic fibrosis and 24 patients suffering from chronic bronchitis, using two CsBr density-gradient centrifugations. The presence of DNA in each secretion was used as an index to estimate the severity of infection and allowed to subdivide the mucins into four groups corresponding to infected or noninfected patients with cystic fibrosis, and to infected or noninfected patients with chronic bronchitis. All infected patients suffering from cystic fibrosis were colonized by Pseudomonas aeruginosa. As already observed, the mucins from the patients with cystic fibrosis had a higher sulfate content than the mucins from the patients with chronic bronchitis. However, there was a striking increase in the sialic acid content of the mucins secreted by severely infected patients as compared to noninfected patients. Thirty-six bronchial mucins out of 38 contained the sialyl-Lewis x epitope which was even expressed by subjects phenotyped as Lewis negative, indicating that at least one alpha1,3 fucosyltransferase different from the Lewis enzyme was involved in the biosynthesis of this epitope. Finally, the sialyl-Lewis x determinant was also overexpressed in the mucins from severely infected patients. Altogether these differences in the glycosylation process of mucins from infected and noninfected patients suggest that bacterial infection influences the expression of sialyltransferases and alpha1,3 fucosyltransferases in the human bronchial mucosa.  (+info)

Sulphation and secretion of the predominant secretory human colonic mucin MUC2 in ulcerative colitis. (6/2610)

BACKGROUND: Decreased synthesis of the predominant secretory human colonic mucin (MUC2) occurs during active ulcerative colitis. AIMS: To study possible alterations in mucin sulphation and mucin secretion, which could be the cause of decreased mucosal protection in ulcerative colitis. METHODS: Colonic biopsy specimens from patients with active ulcerative colitis, ulcerative colitis in remission, and controls were metabolically labelled with [35S]-amino acids or [35S]-sulphate, chase incubated and analysed by SDS-PAGE, followed by quantitation of mature [35S]-labelled MUC2. For quantitation of total MUC2, which includes non-radiolabelled and radiolabelled MUC2, dot blotting was performed, using a MUC2 monoclonal antibody. RESULTS: Between patient groups, no significant differences were found in [35S]-sulphate content of secreted MUC2 or in the secreted percentage of either [35S]-amino acid labelled MUC2 or total MUC2. During active ulcerative colitis, secretion of [35S]-sulphate labelled MUC2 was significantly increased twofold, whereas [35S]-sulphate incorporation into MUC2 was significantly reduced to half. CONCLUSIONS: During active ulcerative colitis, less MUC2 is secreted, because MUC2 synthesis is decreased while the secreted percentage of MUC2 is unaltered. Furthermore, sulphate content of secreted MUC2 is unaltered by a specific compensatory mechanism, because sulphated MUC2 is preferentially secreted while sulphate incorporation into MUC2 is reduced.  (+info)

Mucin expression and function in the female reproductive tract. (7/2610)

Reproductive tract epithelia are characterized by the presence of a thick, apical glycocalyx. This glycoprotein coat is drastically reduced in the uterus of many species during the time of embryo implantation. Recent studies indicate that mucin glycoproteins constitute a large proportion of the apical glycocalyx. One of these mucins, Muc-1, has particularly important functions at the luminal surface of the uterus and other female reproductive tract tissues. Muc-1 appears to play a dominant role in maintaining a functionally non-receptive uterine surface with regard to blastocyst attachment. Conversion to a receptive uterine state is brought about by the concerted actions of ovarian steroid hormones that in several species also strongly modulate Muc-1 protein and mRNA expression. Muc-1 also appears to serve a general function in protecting reproductive tract mucosa since Muc-1 null mice are particularly prone to bacterial infection. Collectively, these studies indicate that mucins, including Muc-1, play important barrier roles in reproductive processes and protection from bacterial pathogenesis in the female reproductive tract.  (+info)

pH-dependent conformational change of gastric mucin leads to sol-gel transition. (8/2610)

We present dynamic light scattering (DLS) and hydrophobic dye-binding data in an effort to elucidate a molecular mechanism for the ability of gastric mucin to form a gel at low pH, which is crucial to the barrier function of gastric mucus. DLS measurements of dilute mucin solutions were not indicative of intermolecular association, yet there was a steady fall in the measured diffusion coefficient with decreasing pH, suggesting an apparent increase in size. Taken together with the observed rise in depolarized scattering ratio with decreasing pH, these results suggest that gastric mucin undergoes a conformational change from a random coil at pH >/= 4 to an anisotropic, extended conformation at pH < 4. The increased binding of mucin to hydrophobic fluorescent with decreasing pH indicates that the change to an extended conformation is accompanied by exposure of hydrophobic binding sites. In concentrated mucin solutions, the structure factor S(q, t) derived from DLS measurements changed from a stretched exponential decay at pH 7 to a power-law decay at pH 2, which is characteristic of a sol-gel transition. We propose that the conformational change facilitates cross-links among mucin macromolecules through hydrophobic interactions at low pH, which in turn leads to a sol-gel transition when the mucin solution is sufficiently concentrated.  (+info)

Mucins are high molecular weight, heavily glycosylated proteins that are the major components of mucus. They are produced and secreted by specialized epithelial cells in various organs, including the respiratory, gastrointestinal, and urogenital tracts, as well as the eyes and ears.

Mucins have a characteristic structure consisting of a protein backbone with numerous attached oligosaccharide side chains, which give them their gel-forming properties and provide a protective barrier against pathogens, environmental insults, and digestive enzymes. They also play important roles in lubrication, hydration, and cell signaling.

Mucins can be classified into two main groups based on their structure and function: secreted mucins and membrane-bound mucins. Secreted mucins are released from cells and form a physical barrier on the surface of mucosal tissues, while membrane-bound mucins are integrated into the cell membrane and participate in cell adhesion and signaling processes.

Abnormalities in mucin production or function have been implicated in various diseases, including chronic inflammation, cancer, and cystic fibrosis.

Gastric mucins refer to the mucin proteins that are produced and secreted by the mucus-secreting cells in the stomach lining, also known as gastric mucosa. These mucins are part of the gastric mucus layer that coats and protects the stomach from damage caused by digestive acids and enzymes, as well as from physical and chemical injuries.

Gastric mucins have a complex structure and are composed of large glycoprotein molecules that contain both protein and carbohydrate components. They form a gel-like substance that provides a physical barrier between the stomach lining and the gastric juices, preventing acid and enzymes from damaging the underlying tissues.

There are several types of gastric mucins, including MUC5AC and MUC6, which have different structures and functions. MUC5AC is the predominant mucin in the stomach and is produced by surface mucous cells, while MUC6 is produced by deeper glandular cells.

Abnormalities in gastric mucin production or composition can contribute to various gastrointestinal disorders, including gastritis, gastric ulcers, and gastric cancer.

Mucin-5B, also known as MUC5B, is a type of mucin protein that is heavily glycosylated and found in the respiratory tract. It is one of the major components of airway mucus, which helps to trap and remove inhaled particles and microorganisms from the lungs.

Mucin-5B is a large molecular weight gel-forming mucin that is produced by goblet cells and submucosal glands in the respiratory epithelium. It has a complex structure, consisting of a protein backbone with numerous oligosaccharide side chains that give it its gel-like properties.

Mutations in the MUC5B gene have been associated with several lung diseases, including chronic obstructive pulmonary disease (COPD), bronchiectasis, and idiopathic pulmonary fibrosis (IPF). In particular, a common genetic variant in the MUC5B promoter region has been identified as a significant risk factor for developing IPF.

Mucin-1, also known as MUC1, is a type of protein called a transmembrane mucin. It is heavily glycosylated and found on the surface of many types of epithelial cells, including those that line the respiratory, gastrointestinal, and urogenital tracts.

Mucin-1 has several functions, including:

* Protecting the underlying epithelial cells from damage caused by friction, chemicals, and microorganisms
* Helping to maintain the integrity of the mucosal barrier
* Acting as a receptor for various signaling molecules
* Participating in immune responses

In cancer, MUC1 can be overexpressed or aberrantly glycosylated, which can contribute to tumor growth and metastasis. As a result, MUC1 has been studied as a potential target for cancer immunotherapy.

Mucin-4, also known as "Podocalyxin-like" or "PODXL," is a type of transmembrane mucin protein that is heavily glycosylated. It is primarily expressed on the surface of certain types of cells, including epithelial and endothelial cells.

Mucin-4 is a large molecule with a molecular weight ranging from 150 to 250 kDa, depending on its degree of glycosylation. It has a extracellular domain that contains several N-linked glycans and O-linked oligosaccharides, which give it a highly extended structure and contribute to its ability to form protective barriers on the cell surface.

Mucin-4 is involved in various biological processes, such as providing a barrier function, regulating cell adhesion, and modulating immune responses. It has been implicated in several diseases, including cancer, where it can promote tumor growth and metastasis by facilitating cell migration and invasion. In the kidney, Mucin-4 is expressed on the surface of podocytes, which are specialized epithelial cells that play a critical role in maintaining the filtration barrier in the glomerulus. Mutations in the MUC16 gene, which encodes Mucin-4, have been associated with nephrotic syndrome, a kidney disorder characterized by proteinuria and edema.

Mucin-3, also known as MUC3A or CA15-3, is a type of mucin protein that is heavily glycosylated and found on the apical surface of epithelial cells in the gastrointestinal tract. It is a transmembrane protein that plays a role in protecting the epithelial surface from damage, infection, and inflammation. Mucin-3 has been identified as a tumor antigen and its expression is often upregulated in various types of cancer, including colon, pancreatic, and ovarian cancers. The soluble form of Mucin-3 can be measured in the blood and used as a tumor marker to monitor the progression of certain cancers.

I'm sorry for any confusion, but "Mucin-6" is not a widely recognized or established medical term. Mucins are high molecular weight glycoproteins that are the major component of mucus, which is produced by specialized epithelial cells in various organs. Each mucin is identified by a number, such as Mucin-1, Mucin-2, and so on, based on their order of discovery.

However, I couldn't find any reputable medical sources that mention "Mucin-6." It's possible that it may be a topic of ongoing research or that it might be referred to by another name. I would recommend consulting a specific scientific study or researcher for more accurate and detailed information.

Goblet cells are specialized epithelial cells that are located in various mucosal surfaces, including the respiratory and gastrointestinal tracts. They are named for their goblet-like shape, which is characterized by a narrow base and a wide, rounded top that contains secretory granules. These cells play an essential role in producing and secreting mucins, which are high molecular weight glycoproteins that form the gel-like component of mucus.

Mucus serves as a protective barrier for the underlying epithelial cells by trapping foreign particles, microorganisms, and toxins, preventing them from coming into contact with the epithelium. Goblet cells also help maintain the hydration of the mucosal surface, which is important for normal ciliary function in the respiratory tract and for the movement of food through the gastrointestinal tract.

In summary, goblet cells are secretory cells that produce and release mucins to form the mucus layer, providing a protective barrier and maintaining the homeostasis of mucosal surfaces.

Mucus is a viscous, slippery secretion produced by the mucous membranes that line various body cavities such as the respiratory and gastrointestinal tracts. It serves to lubricate and protect these surfaces from damage, infection, and foreign particles. Mucus contains water, proteins, salts, and other substances, including antibodies, enzymes, and glycoproteins called mucins that give it its characteristic gel-like consistency.

In the respiratory system, mucus traps inhaled particles such as dust, allergens, and pathogens, preventing them from reaching the lungs. The cilia, tiny hair-like structures lining the airways, move the mucus upward toward the throat, where it can be swallowed or expelled through coughing or sneezing. In the gastrointestinal tract, mucus helps protect the lining of the stomach and intestines from digestive enzymes and other harmful substances.

Excessive production of mucus can occur in various medical conditions such as allergies, respiratory infections, chronic lung diseases, and gastrointestinal disorders, leading to symptoms such as coughing, wheezing, nasal congestion, and diarrhea.

Sialomucins are a type of glycoprotein mucins that contain high amounts of sialic acid, which is a family of negatively charged sugars found on the surface of many cell types. These mucins are produced by the major salivary glands and are a major component of saliva. They play an important role in lubricating and protecting the oral cavity, as well as contributing to the mouth's ability to resist infection and damage.

Sialomucins have also been shown to have various biological functions, such as regulating cell adhesion, modulating immune responses, and serving as receptors for certain viruses and bacteria. Abnormalities in sialomucin expression or structure have been implicated in several diseases, including cancer, autoimmune disorders, and infectious diseases.

Glycosylation is the enzymatic process of adding a sugar group, or glycan, to a protein, lipid, or other organic molecule. This post-translational modification plays a crucial role in modulating various biological functions, such as protein stability, trafficking, and ligand binding. The structure and composition of the attached glycans can significantly influence the functional properties of the modified molecule, contributing to cell-cell recognition, signal transduction, and immune response regulation. Abnormal glycosylation patterns have been implicated in several disease states, including cancer, diabetes, and neurodegenerative disorders.

Tumor-associated carbohydrate antigens (TACAs) are a type of tumor antigen that are expressed on the surface of cancer cells. These antigens are abnormal forms of carbohydrates, also known as glycans, which are attached to proteins and lipids on the cell surface.

TACAs are often overexpressed or expressed in a different form on cancer cells compared to normal cells. This makes them attractive targets for cancer immunotherapy because they can be recognized by the immune system as foreign and elicit an immune response. Some examples of TACAs include gangliosides, fucosylated glycans, and sialylated glycans.

Tumor-associated carbohydrate antigens have been studied as potential targets for cancer vaccines, antibody therapies, and other immunotherapeutic approaches. However, their use as targets for cancer therapy is still in the early stages of research and development.

Oligosaccharides are complex carbohydrates composed of relatively small numbers (3-10) of monosaccharide units joined together by glycosidic linkages. They occur naturally in foods such as milk, fruits, vegetables, and legumes. In the body, oligosaccharides play important roles in various biological processes, including cell recognition, signaling, and protection against pathogens.

There are several types of oligosaccharides, classified based on their structures and functions. Some common examples include:

1. Disaccharides: These consist of two monosaccharide units, such as sucrose (glucose + fructose), lactose (glucose + galactose), and maltose (glucose + glucose).
2. Trisaccharides: These contain three monosaccharide units, like maltotriose (glucose + glucose + glucose) and raffinose (galactose + glucose + fructose).
3. Oligosaccharides found in human milk: Human milk contains unique oligosaccharides that serve as prebiotics, promoting the growth of beneficial bacteria in the gut. These oligosaccharides also help protect infants from pathogens by acting as decoy receptors and inhibiting bacterial adhesion to intestinal cells.
4. N-linked and O-linked glycans: These are oligosaccharides attached to proteins in the body, playing crucial roles in protein folding, stability, and function.
5. Plant-derived oligosaccharides: Fructooligosaccharides (FOS) and galactooligosaccharides (GOS) are examples of plant-derived oligosaccharides that serve as prebiotics, promoting the growth of beneficial gut bacteria.

Overall, oligosaccharides have significant impacts on human health and disease, particularly in relation to gastrointestinal function, immunity, and inflammation.

The trachea, also known as the windpipe, is a tube-like structure in the respiratory system that connects the larynx (voice box) to the bronchi (the two branches leading to each lung). It is composed of several incomplete rings of cartilage and smooth muscle, which provide support and flexibility. The trachea plays a crucial role in directing incoming air to the lungs during inspiration and outgoing air to the larynx during expiration.

The Periodic Acid-Schiff (PAS) reaction is a histological staining method used to detect the presence of certain carbohydrates, such as glycogen and glycoproteins, in tissues or cells. This technique involves treating the tissue with periodic acid, which oxidizes the vicinal hydroxyl groups in the carbohydrates, creating aldehydes. The aldehydes then react with Schiff's reagent, forming a magenta-colored complex that is visible under a microscope.

The PAS reaction is commonly used to identify and analyze various tissue components, such as basement membranes, fungal cell walls, and mucins in the respiratory and gastrointestinal tracts. It can also be used to diagnose certain medical conditions, like kidney diseases, where abnormal accumulations of carbohydrates occur in the renal tubules or glomeruli.

In summary, the Periodic Acid-Schiff reaction is a staining method that detects specific carbohydrates in tissues or cells, which can aid in diagnostic and research applications.

Carbohydrates are a major nutrient class consisting of organic compounds that primarily contain carbon, hydrogen, and oxygen atoms. They are classified as saccharides, which include monosaccharides (simple sugars), disaccharides (double sugars), oligosaccharides (short-chain sugars), and polysaccharides (complex carbohydrates).

Monosaccharides, such as glucose, fructose, and galactose, are the simplest form of carbohydrates. They consist of a single sugar molecule that cannot be broken down further by hydrolysis. Disaccharides, like sucrose (table sugar), lactose (milk sugar), and maltose (malt sugar), are formed from two monosaccharide units joined together.

Oligosaccharides contain a small number of monosaccharide units, typically less than 20, while polysaccharides consist of long chains of hundreds to thousands of monosaccharide units. Polysaccharides can be further classified into starch (found in plants), glycogen (found in animals), and non-starchy polysaccharides like cellulose, chitin, and pectin.

Carbohydrates play a crucial role in providing energy to the body, with glucose being the primary source of energy for most cells. They also serve as structural components in plants (cellulose) and animals (chitin), participate in various metabolic processes, and contribute to the taste, texture, and preservation of foods.

The intestinal mucosa is the innermost layer of the intestines, which comes into direct contact with digested food and microbes. It is a specialized epithelial tissue that plays crucial roles in nutrient absorption, barrier function, and immune defense. The intestinal mucosa is composed of several cell types, including absorptive enterocytes, mucus-secreting goblet cells, hormone-producing enteroendocrine cells, and immune cells such as lymphocytes and macrophages.

The surface of the intestinal mucosa is covered by a single layer of epithelial cells, which are joined together by tight junctions to form a protective barrier against harmful substances and microorganisms. This barrier also allows for the selective absorption of nutrients into the bloodstream. The intestinal mucosa also contains numerous lymphoid follicles, known as Peyer's patches, which are involved in immune surveillance and defense against pathogens.

In addition to its role in absorption and immunity, the intestinal mucosa is also capable of producing hormones that regulate digestion and metabolism. Dysfunction of the intestinal mucosa can lead to various gastrointestinal disorders, such as inflammatory bowel disease, celiac disease, and food allergies.

A "carbohydrate sequence" refers to the specific arrangement or order of monosaccharides (simple sugars) that make up a carbohydrate molecule, such as a polysaccharide or an oligosaccharide. Carbohydrates are often composed of repeating units of monosaccharides, and the sequence in which these units are arranged can have important implications for the function and properties of the carbohydrate.

For example, in glycoproteins (proteins that contain carbohydrate chains), the specific carbohydrate sequence can affect how the protein is processed and targeted within the cell, as well as its stability and activity. Similarly, in complex carbohydrates like starch or cellulose, the sequence of glucose units can determine whether the molecule is branched or unbranched, which can have implications for its digestibility and other properties.

Therefore, understanding the carbohydrate sequence is an important aspect of studying carbohydrate structure and function in biology and medicine.

The conjunctiva is the mucous membrane that lines the inner surface of the eyelids and covers the front part of the eye, also known as the sclera. It helps to keep the eye moist and protected from irritants. The conjunctiva can become inflamed or infected, leading to conditions such as conjunctivitis (pink eye).

An encyclopedia is a comprehensive reference work containing articles on various topics, usually arranged in alphabetical order. In the context of medicine, a medical encyclopedia is a collection of articles that provide information about a wide range of medical topics, including diseases and conditions, treatments, tests, procedures, and anatomy and physiology. Medical encyclopedias may be published in print or electronic formats and are often used as a starting point for researching medical topics. They can provide reliable and accurate information on medical subjects, making them useful resources for healthcare professionals, students, and patients alike. Some well-known examples of medical encyclopedias include the Merck Manual and the Stedman's Medical Dictionary.

Nacre is not typically defined in the context of medicine, but it is a term used in the field of dentistry. Medically, nacre refers to the mother of pearl substance that lines the inner shell of mollusks and pearls, which has been used as a material for making dental restorations due to its toughness and iridescent appearance. It can also be referred to as "mophus" in dentistry.

In medical terms, lubrication refers to the application of a slippery substance or fluid to reduce friction and facilitate smooth movement between two surfaces. This is particularly relevant in the context of human anatomy, where lubrication plays a crucial role in various bodily functions. For instance, the mucous membranes that line body cavities such as the mouth, vagina, and rectum secrete fluids to provide lubrication for easy movement of tissues and foreign substances (like food or during sexual intercourse). Similarly, synovial fluid, a viscous substance found in joints, provides lubrication that enables smooth articulation between bones. Artificial lubricants may also be used in medical procedures to facilitate the insertion and movement of medical devices such as catheters or endoscopes.

'Striga' is not a term commonly used in medical definitions. It is actually a genus of parasitic plants, also known as witchweeds, that can cause significant damage to crops and lead to agricultural losses, particularly in Africa.

However, if you are referring to 'Striae', it is a medical term that describes linear or curvilinear grooves or furrows on the skin surface. These depressions can be either shallow or deep and may have various causes, such as scratch marks, healing processes of dermatological conditions, or underlying medical disorders.

"Pinctada" is not a medical term, but a biological genus name. It refers to a group of saltwater clams, also known as pearl oysters, that are part of the family Pteriidae. These species, including Pinctada maxima, Pinctada margaritifera, and Pinctada radiata, are known for their ability to produce high-quality pearls.

The misconception might arise from the fact that some people confuse "Pinctada" with a medical or healthcare term related to human health. However, it is essential to clarify that "Pinctada" is purely a zoological term used in the classification of certain types of mollusks.

Human mucins include genes with the HUGO symbol MUC 1 through 22. Of these mucins, the following classes have been defined by ... Mucin genes encode mucin monomers that are synthesized as rod-shaped apomucin cores that are post-translationally modified by ... Mucins at the U.S. National Library of Medicine Medical Subject Headings (MeSH) "Mucin" at Dorland's Medical Dictionary (CS1: ... Overexpression of the mucin proteins, especially MUC1, is associated with many types of cancer. Although some mucins are ...
Mucin-4 (MUC-4) is a mucin protein that in humans is encoded by the MUC4 gene. Like other mucins, MUC-4 is a high-molecular ... As a mucin, MUC-4 also alters adhesive properties of the cell. When overexpressed, the disorganization of mucins may reduce ... "Entrez Gene: MUC-4 mucin 4, cell surface associated". "MUC4 (mucin 4, cell surface associated)". Atlas of Genetics and ... MUC4 mucin consists of a large extracellular alpha subunit that is heavily glycosylated and a beta subunit that is anchored in ...
"Characterization of the human mucin gene MUC5AC: a consensus cysteine-rich domain for 11p15 mucin genes?". Biochem J. 305 (Pt 1 ... Mucin-5AC (MUC-5AC) is a protein that in humans is encoded by the MUC5AC gene. MUC-5AC is a large gel-forming glycoprotein. In ... "Entrez Gene: MUC5AC mucin 5AC, oligomeric mucus/gel-forming". Samsuzzaman M, Uddin MS, Shah MA, Mathew B (August 2019). " ... PDBe-KB provides an overview of all the structure information available in the PDB for Human Mucin-5AC v t e (Articles with ...
"Entrez Gene: MUC6 mucin 6, oligomeric mucus/gel-forming". Monges GM, Mathoulin-Portier MP (2005). "Role of Mucins in Pancreatic ... Mucin 6, oligomeric mucus/gel-forming, also known as MUC6, is a human gene encoding a protein of the same name. MUC6, along ... Mucins, All stub articles, Human chromosome 11 gene stubs). ...
Mucin-17 is a protein that in humans is encoded by the MUC17 gene. Membrane mucins, such as MUC17, function in epithelial cells ... "Entrez Gene: MUC17 mucin 17, cell surface associated". Kitamoto S, Yamada N, Yokoyama S, et al. (2011). "DNA methylation and ... Gum JR Jr; Crawley SC; Hicks JW; Szymkowski DE; Kim YS (Feb 2002). "MUC17, a novel membrane-tethered mucin". Biochem Biophys ... 2008). "The C-terminus of the transmembrane mucin MUC17 binds to the scaffold protein PDZK1 that stably localizes it to the ...
... is a protein that in humans is encoded by the MUC3A gene. GRCh38: Ensembl release 89: ENSG00000169894 - Ensembl, May ... "Entrez Gene: MUC3A mucin 3A, cell surface associated". v t e (Articles with short description, Short description matches ... "Molecular cloning of cDNAs derived from a novel human intestinal mucin gene". Biochem Biophys Res Commun. 171 (1): 407-15. doi: ... Wikidata, Genes on human chromosome 7, Mucins, All stub articles, Protein stubs). ...
There, mucin 2, along with small amounts of related-mucin proteins, polymerizes into a gel of which 80% by weight is ... This gene encodes a member of the mucin protein family. The protein encoded by this gene, also called mucin 2, is secreted onto ... Mucin 2 is particularly prominent in the gut where it is secreted from goblet cells in the epithelial lining into the lumen of ... Mucin 2, oligomeric mucus gel-forming, also known as MUC2, is a protein that in humans is encoded by the MUC2 gene. ...
"Entrez Gene: MUC5B mucin 5B, oligomeric mucus/gel-forming". "MUC5B mucin 5B, oligomeric mucus/gel-forming [Homo sapiens (human ... Mucin-5B (MUC-5B) is a protein that in humans is encoded by the MUC5B gene and by Muc5b gene in mouse. It is one of the five ... All mucins are synthesized in secretory cells known, dependent on the tissue they are located in, as goblet cells or mucous ... Desseyn JL, Aubert JP, Van Seuningen I, Porchet N, Laine A (1997). "Genomic organization of the 3' region of the human mucin ...
... (MUC-1) is a heterodimer transmembrane protein of the mucin family encoded in humans by the MUC1 gene. It is cleaved ... O-glycosylation and N-glycosylation in MUC-1 contribute to the formation of mucin. MUC-1 is a transcriptional coactivator ... into two chains: mucin-1 subunit alpha (MUC1-NT; MUC1-alpha) and mucin-1 subunit beta (MUC-CT; MUC1-beta). These subunits ... v t e (Articles with short description, Short description is different from Wikidata, Genes on human chromosome 1, Mucins, ...
Mucin-7 is a protein that in humans is encoded by the MUC7 gene. In animals, the MUC7 gene is found in most placental mammals, ... "Entrez Gene: MUC7 mucin 7, secreted". Xu D, Pavlidis P, Thamadilok S, Redwood E, Fox S, Blekhman R, Ruhl S, Gokcumen O (August ... Li S, Intini G, Bobek LA (July 2006). "Modulation of MUC7 mucin expression by exogenous factors in airway cells in vitro and in ... Ge J, Catt DM, Gregory RL (November 2004). "Streptococcus mutans surface alpha-enolase binds salivary mucin MG2 and human ...
"Entrez Gene: MUC20 mucin 20, cell surface associated". Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: ... Mucin-20 is a protein that in humans is encoded by the MUC20 gene. ENSG00000281630, ENSG00000277753, ENSG00000275501, ... v t e (Articles with short description, Short description matches Wikidata, Genes on human chromosome 3, Mucins, All stub ... a novel mucin protein, up-regulated in injured kidney". J Biol Chem. 279 (3): 1968-79. doi:10.1074/jbc.M304558200. PMID ...
Mucin 16 is a membrane associated mucin that possesses a single transmembrane domain. A unique property of MUC16 is its large ... Mucin-16 (MUC-16) also known as Ovarian cancer-related tumor marker CA125 is a protein that in humans is encoded by the MUC16 ... The expression of mucin 16 has been shown to be altered in dry eye, cystic fibrosis, and several types of cancers. MUC16 (CA- ... All mucins contain a tandem repeat domain that has repeating amino acid sequences high in serine, threonine and proline. The C- ...
... , also called polymorphic epithelial mucin (PEM) or epithelial membrane antigen (EMA), is a mucin encoded ... Mucin short variant S1 is a glycoprotein with extensive O-linked glycosylation of its extracellular domain. Mucins line the ... The release of mucins is performed by sheddases. The extracellular domain includes a 20 amino acid variable number tandem ... Mucins protect the body from infection by pathogen binding to oligosaccharides in the extracellular domain, preventing the ...
The two main components of the gel are mucins and water, with the mucins forming the backbone of the mucous. Mucin originates ... The adsorbtion of mucin will alter the refractive index which can be used to calculate the amount of mucin molecules in the ... The amount of mucin removed was a small fraction of the remaining material. A different method to determine the amount of mucin ... The secreted mucin assists in digestion by coating the bolus such that it travels easily through the digestive tract. Mucins ...
... is a protein that in humans is encoded by the MUC21 gene. "Human PubMed Reference:". National ... "Entrez Gene: Mucin 21, cell surface associated". Retrieved 2016-02-08. v t e (Articles with short description, Short ... description matches Wikidata, Human genes, All stub articles, Human chromosome 6 gene stubs, Mucins). ...
Stacey M, Lin HH, Hilyard KL, Gordon S, McKnight AJ (2001). "Human epidermal growth factor (EGF) module-containing mucin-like ... The EGF module-containing Mucin-like hormone Receptors (EMRs) are closely related subgroup of G protein-coupled receptors ( ... like domain is fused to a GPCR domain through a mucin-like stalk. There are four variants of EMR labeled 1-4, each encoded by a ...
They analysed gastrointestinal mucins initially because the oligosaccharides were similar to those of cell membranes but mucins ... In addition, mucins were an important part of cellular defences so of interest in their own right. They were able to define the ... Hounsell, E F; Feizi, T (1982). "Gastrointestinal mucins. Structures and antigenicities of their carbohydrate chains in health ... Biochemical Society Transactions 12 (4) 591-596 E F Hounsell and T Feizi (1982) Gastrointestinal mucins - structures and ...
Mucins thicken mucus, and their concentration has been found to be high in cases of chronic bronchitis, and also to correlate ... Chronic bronchitis is marked by mucus hypersecretion and mucins. The excess mucus is produced by an increased number of goblet ... Effective mucociliary clearance depends on airway hydration, ciliary beating, and the rates of mucin secretion. Each of these ... Voynow, J (Feb 2009). "Mucins, mucus, and sputum". Chest. 135 (2): 505-512. doi:10.1378/chest.08-0412. PMID 19201713. Vestbo, J ...
Analysis of substrates and products for four N-acetyl-D-glucosaminyl-transferases involved in mucin synthesis". Carbohydrate ... I. Detection in canine submaxillary glands of an N-acetylglucosaminyltransferase which acts on mucin substrates". The Journal ... Williams D, Longmore G, Matta KL, Schachter H (December 1980). "Mucin synthesis. II. Substrate specificity and product ... uridine diphosphoacetylglucosamine-mucin beta-(1->6)-acetylglucosaminyltransferase, core 2 acetylglucosaminyltransferase, core ...
I. Detection in canine submaxillary glands of an N-acetylglucosaminyltransferase which acts on mucin substrates". J Biol Chem. ...
... glycolipids and mucins in tissues. The reaction of periodic acid oxidizes the vicinal diols in these sugars, usually breaking ... which often secrete neutral mucins. Paget disease of the breast. Alveolar soft part sarcoma. Staining macrophages in Whipple's ...
Her studies have shown that mucins and specific mucin glycans induce a morphological change, accompanied by a reduction in ... Ribbeck demonstrated that mucin glycans can reduce the virulence of pathogens such as Pseudomonas aeruginosa, a bacterium that ... Her work has elucidated the role of mucins, a primary component of mucus, in human health. Ribbeck is known for her pioneering ... Her work has also shown that mucins found in multiple types of mucus, including human spit, can prevent fungal pathogens from ...
The major mucins secreted - MUC5AC and MUC5B - are large polymers that give the mucus its rheologic or viscoelastic properties ... MUC5AC is the main gel-forming mucin secreted by goblet cells, in the form of threads and thin sheets. MUC5B is a polymeric ... Mucins, a kind of polyelectrolyte proteoglycans, are the main component of mucus, which provides the polyelectrolyte effect in ... For instance, the charged residue on mucin is protonated at a normal pH value of the stomach, approximately pH 2. In this case ...
They also secrete mucin. The intercalated ducts take the bicarbonate to intralobular ducts which become lobular ducts. These ...
nov., a new member of the family Chitinophagaceae producing mucin". Journal of Microbiology. 57 (5): 356-361. doi:10.1007/ ... Mucibacter soli produces mucin. "Genus: Mucibacter". LPSN.DSMZ.de. Kim, Min-Kyeong; Park, Sewook; Kim, Tae-Su; Joung, Yochan; ...
Naresh, Ram; Hampson, David J. (1 January 2010). "Attraction of Brachyspira pilosicoli to mucin". Microbiology. 156 (Pt 1): 191 ... Ogata, Sho; Shimizu, Ken; Tominaga, Susumu; Nakanishi, Kuniaki (2017). "Immunohistochemical study of mucins in human intestinal ... mucin layers thanks to its spiroid shape and flagellum (see film ), attach to colonocytes apically and to each other laterally ... the body with mucins to invade, epithelia to attach and glucose available. Brachyspira may be a sexually transmittable disease ...
Die Mucin-Polysaccharide der Eiweißdrüse. 1. Mitteil.: Die Identität von Galaktogen und Sinistrin. Hoppe-Seyler's Zeitschrift ...
... stains acid mucins to yellow color. It also stains mast cell granules brown. It can be used with live cells. ...
Immunoprecipitation reveals FREPs and mucins bound to each other. This suggests FREPs are detecting these mucins and ... On the schistosome's part the Roger group (in Roger et al 2008 a & b) find that S. mansoni produces mucins. ...
Naughton J, Duggan G, Bourke B, Clyne M (2014). "Interaction of microbes with mucus and mucins: recent developments". Gut ...
Human mucins include genes with the HUGO symbol MUC 1 through 22. Of these mucins, the following classes have been defined by ... Mucin genes encode mucin monomers that are synthesized as rod-shaped apomucin cores that are post-translationally modified by ... Mucins at the U.S. National Library of Medicine Medical Subject Headings (MeSH) "Mucin" at Dorlands Medical Dictionary (CS1: ... Overexpression of the mucin proteins, especially MUC1, is associated with many types of cancer. Although some mucins are ...
PTS-repeats are a hallmark of the mucin group of proteins6. Mucins are highly glycosylated proteins that serve a variety of ... It should be noted here that most other mucins, including MUC1, MUC4, and MUC6, have intact PTS-repeats in mouse33,34,35, ... In fact, mucins, as a functional group, are defined by the presence of PTS-rich repeats6, where T and S clusters provide ... Desseyn, J.-L. & Mucin C. Y. S. domains are ancient and highly conserved modules that evolved in concert. Mol. Phylogenet. Evol ...
Home Topics Infectious Diseases Mucin Gene Promotor SNP Linked to Risk of Pulmonary Fibrosis ... The studies, combined with mucin gene resequencing, homed in on a SNP in the putative promoter of MUC5B, 3 kb upstream of the ...
Mucin MUC7, Mucins - Potential Regulators of Cell Functions Volume Title: Gel-Forming and Soluble Mucins (2013) 1: 398. https ... Mucins - Potential Regulators of Cell Functions Volume Title: Gel-Forming and Soluble Mucins ... Mucin MUC7. Author(s): Joseph Z. Zaretsky and *Department of Cell Research and Immunology George S. Wise Faculty of Life ... The MUC7 gene belongs to a group of genes encoding soluble mucin glycoproteins. This chapter describes the structure of the ...
... snail mucin is taking the beauty world by storm. Heres what to know about this game-changing ingredient. ... Snail-mucin use is an age-old practice. Natallia Boroda/Shutterstock To be clear, the use of snail slime for beauty and health ... Snail Mucin: Where Does The Product Fit In Your Skincare Routine?. EXCLUSIVES POLITICS RELATIONSHIPS SEX WELLNESS BEAUTY ... If youre curious to see how it works for your skin, start with a water-based snail mucin essence, as cosmetic chemist Georgia ...
... snail mucin and shoppers say it has transformed their skin. ... The mucin is then collected and processed for cosmetic use.. ... Before we look at how snail mucin works, its worth mentioning that COSRX and other brands that work with snail mucin say no ... This snail mucin cream has over 17,000 Amazon reviews with shoppers claiming theyre shocked by the results. Comment ... Since snail mucin is relatively new in the skincare world there arent that many clinical studies for academic proof - so for ...
... and even influencing the design of mucin-based vaccines. This review discusses the emerging roles of mucins such as MUC1 and ... Mucins are high molecular weight glycoproteins with complex oligosaccharide side chains attached to the apomucin protein ... Changes in the sequence of glycosylation of mucins in different settings generate a variety of epitopes in the oligosaccharide ... Furthermore the type, pattern and amount of mucin secreted in some tissues have been considered in the classification and ...
Mucin. A glyco-protein which forms part of the tear film. It increases viscosity of the tear film necessary for effective ...
Mucin-1 kidney disease, previously described as medullary cystic kidney disease type 1 (MCKD1, OMIM 174000), is an autosomal ... Development and Validation of a Mass Spectrometry-Based Assay for the Molecular Diagnosis of Mucin-1 Kidney Disease. Author(s) ... Because of variable age of disease onset and often subtle signs and symptoms, clinical diagnosis of mucin-1 kidney disease and ... "Development and Validation of a Mass Spectrometry-Based Assay for the Molecular Diagnosis of Mucin-1 Kidney Disease." The ...
Histochemistry showed the mucin content of these cells to consist uniformly of sulphated acid mucins; positive thyroglobulin ... An unusual case of a mucin secreting benign microfollicular adenoma of the thyroid in a 30 year old euthyroid woman is reported ... The published work on primary mucin secreting tumours of the thyroid gland is reviewed. Dual differentiation is thought to be ... responsible for combined mucin secretion and hormone production in this type of neoplasm. ...
Snail mucin can be found in a wide variety of skin care products, so there are many ways to incorporate this ingredient into ... CosRX Snail Mucin Sheet Mask Sold in a 10-pack, these sheet masks are drenched with COSRXs bestselling snail 96 mucin power ... Why is snail mucin thought to be good for skin?. "Snail mucin contains hyaluronic acid, glycolic acid and glycoproteins which ... Best ways to incorporate snail mucin into your skin care routine. Snail mucin can be found in a wide variety of skin care ...
A new mucin antibody/enzyme-linked lectin-sandwich assay of serum MUC5AC mucin for the diagnosis of cholangiocarcinoma. Cancer ... Total mucin in culture supernatants was measured using enzyme-linked lectin assay. Enzyme-linked immunosorbent assay was used ... Macrolides Attenuate Phorbol Ester-Induced Tumor Necrosis Factor-α and Mucin Production from Human Airway Epithelial Cells ... Kim YD, Cho JS, Kim HS, Song SH: Effect of macrolide on the interleukin-1 β-mediated MUC2/5AC genes expression and mucin ...
Mucin (Qniumucin), a Glycoprotein from Jellyfish, and Determination of Its Main Chain Structure ... GalNAcMUC5ACspeciesmucin familymemberacidMucinQniumucinthreonine residuesDeterminationmarine resourceacetyl-d-galactosamine ... We extracted a novel glycoprotein, a member of the mucin family, from five species of jellyfish with high yields (1%−3% dry ... Mucin (Qniumucin), a Glycoprotein from Jellyfish, and Determination of Its Main Chain Structure. ...
Mucin 5AC) Mouse Monoclonal IgG Antibody. Immunohistochemistry (IHC) applications. Human specificity ... The MUC5AC Antibody detects for mucin 5AC (MUC5AC), a secretory-type mucin found in columnar mucous cells of surface gastric ...
In addition, we have examined the bulk rheological effects for synthetic mucus solutions-based on pig gastric mucin (PGM) and ... 435319 Surface and Rheological Effects of Mucus/Mucin Coupled with Chitosan-Coated Gold Nanoparticles Monday, November 9, 2015 ... We have examined surface-functionalized gold nanoparticles (Au NPs) within mucin/mucus matrices to gain a better understanding ... By varying pH, complexation time, concentration, and temperature, the stability of the mucin-chitosan Au nanoparticle complexes ...
Moreover, sulfated mucins appear to accumulate in respiratory diseases, arthritis, and cancer. To explore further the genetic ... Moreover, sulfated mucins appear to accumulate in respiratory diseases, arthritis, and cancer. To explore further the genetic ... Moreover, sulfated mucins appear to accumulate in respiratory diseases, arthritis, and cancer. To explore further the genetic ... Installation of O-glycan sulfation capacities in human HEK293 cells for display of sulfated mucins. *Mark ...
... from prominent mucin degrading gut bacteria that specifically target the oligosaccharide side chains of intestinal mucins from ... Prominent members of the human gut microbiota express endo-acting O-glycanases to initiate mucin breakdown. View ORCID Profile ... The upper layer of the colonic mucus is a niche for a subset of the microbiota which utilise the mucin glycoproteins as a ... The data suggest a new paradigm for mucin breakdown by the microbiota and the endo-mucinases provide a potential tool to ...
Membrane-associated mucins are one of the major components of the ocular surface that play a vital role in the maintenance of ... Membrane-associated mucins (Muc 1 and Muc 16) expressions were subsequently analyzed by Western blot. Winstar Rats were also ... Purpose: : To evaluate the effect of multipurpose contact lens care solutions (MPSs) on membrane-associated mucins (Muc 1 & 16 ... Results: : Western blot results showed that MPSs containing boric acid down-regulate membrane-associated mucins in the cornea ...
Avhandling: Studies on o-glycosylation of mucin-type proteins and their binding to antibodies, bacterial toxins and viral ... The multivalent mucins could adsorb chain type - sp ecific anti - A antibodies, which indicate a prospective use of the mucins ... The mucin - type protein was used as a probe to analyze the O - glycosylation capacity of the se cell lines, which today are ... PSGL - 1 genetically fused to mouse IgG 2b Fc forms a dimeric PSGL - 1/mIgG 2b mucin - type fusion protein. In paper I, PSGL - ...
Byrne, James (1999) Comparative study of intestinal metaplasia and mucin staining at the cardia and esophagogastric junction in ... Comparative study of intestinal metaplasia and mucin staining at the cardia and esophagogastric junction in 225 symptomatic ... Comparative study of intestinal metaplasia and mucin staining at the cardia and esophagogastric junction in 225 symptomatic ... Comparative study of intestinal metaplasia and mucin staining at the cardia and esophagogastric junction in 225 symptomatic ...
1. Presence of, or accumulation of, mucin in the blood.. 2. The presence of mucin in blood, a condition that may occur in ... muco-, muc-, muci-, mucin- + (Latin: mucus, mucous, or mucosa; a viscid, slippery, slime secretion of the mucous membranes; ... Resembling mucin or mucus present in saliva and bile, in salivary glands, and in the skin, connective tissues, tendon, and ... Capable of bringing about the hydrolysis (splitting of a compound into fragments by the addition of water) of mucin, as by a ...
"Mbylle gojën" - Si e kapën kamerat Ernest Mucin duke sharë në gjuhen shqipe trajnerin serb që ia nxiu jetën te Legia ...
With increasing interest on mucins as diagnostic and therapeutic targets in cancers and other diseases, it is becoming ... imperative to characterize novel mucins and investigate their biological significance. Here, we present the completed coding ...
CosRX Snail Mucin Sheet Mask Sold in a 10-pack, these sheet masks are drenched with COSRXs bestselling snail 96 mucin power ... Why is snail mucin thought to be good for skin?. "Snail mucin contains hyaluronic acid, glycolic acid and glycoproteins which ... Best ways to incorporate snail mucin into your skin care routine. Snail mucin can be found in a wide variety of skin care ... How much research has there been on snail mucin?. Its important to note that snail mucins benefits on skin have not been ...
Park, Sangwoo, Chin-Hun Kuo, Joe, Reesink, Heidi L., and Paszek, Matthew J. Recombinant mucin biotechnology and engineering. ... Park, Sangwoo, Chin-Hun Kuo, Joe, Reesink, Heidi L., & Paszek, Matthew J. Recombinant mucin biotechnology and engineering. ... Park, Sangwoo, Chin-Hun Kuo, Joe, Reesink, Heidi L., and Paszek, Matthew J. "Recombinant mucin biotechnology and engineering". ... place = {Country unknown/Code not available}, title = {Recombinant mucin biotechnology and engineering}, url = {https://par.nsf ...
Right now Prime Members can grab this COSRX Snail Mucin 92% Moisturizer 3.52 oz, Daily Repair Face Gel Cream at its lowest ... Amazon Prime Day Deal: COSRX Snail Mucin 92% Moisturizer 3.52 oz, Daily Repair Face Gel Cream. This post may contain affiliate ... Right now Prime Members can grab this COSRX Snail Mucin 92% Moisturizer 3.52 oz, Daily Repair Face Gel Cream at its lowest ... NO Snails are Harmed: Snail Mucin is obtained in a safe and environmentally friendly way in a favorite environment of snails ...
Tear Outflow: Impact of mucins and TFF peptides. / Berry, MS; Paulsen, F. In: Ophthalmology, Vol. 101(1), 2004, p. 19 - 26.. ... Berry, MS ; Paulsen, F. / Tear Outflow: Impact of mucins and TFF peptides. In: Ophthalmology. 2004 ; Vol. 101(1). pp. 19 - 26. ... Berry, MS & Paulsen, F 2004, Tear Outflow: Impact of mucins and TFF peptides, Ophthalmology, vol. 101(1), pp. 19 - 26. ... Berry, MS., & Paulsen, F. (2004). Tear Outflow: Impact of mucins and TFF peptides. Ophthalmology, 101(1), 19 - 26. ...
Structure determination of oligosaccharides isolated from A+, H+ and A- H- hog-submaxillary-gland mucin glycoproteins, by 360- ... Structure determination of oligosaccharides isolated from A+, H+ and A- H- hog-submaxillary-gland mucin glycoproteins, by 360- ...
A transmembrane mucin that is found in a broad variety of epithelial tissue. Mucin-4 may play a role in regulating cellular ... Mucin-4 is a heterodimer of alpha and beta chains. The alpha and beta chains result from the proteolytic cleavage of a ... "Mucin-4" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject Headings) ... This graph shows the total number of publications written about "Mucin-4" by people in UAMS Profiles by year, and whether " ...
Snail Mucin Vitamin C Retinoids & Bakuchiol Ferments & Tea Hyaluronic Acid Peptides/Collagen/Ceramides Niacinamide Honey & ... COSRX Advanced Snail 96 Mucin Power Essence (1+1 Special Set). $30.00 $35.00 ...
  • Upon stimulation, MARCKS (myristylated alanine-rich C kinase substrate) protein coordinates the secretion of mucin from mucin-filled vesicles within the specialized epithelial cells. (wikipedia.org)
  • Dual differentiation is thought to be responsible for combined mucin secretion and hormone production in this type of neoplasm. (bmj.com)
  • Check the label, which should include the concentration of snail mucin," Leer advises, noting that many labels denote the ingredient as snail secretion filtrate rather or snail mucin. (wivb.com)
  • Kim YD, Cho JS, Kim HS, Song SH: Effect of macrolide on the interleukin-1 β-mediated MUC2/5AC genes expression and mucin secretion in human airway epithelial cells. (karger.com)
  • Long-lasting Hydration: Infused with 92% of snail mucin (also called Snail Secretion Filtrate), this cream builds a moisture barrier to plump, hydrate, and soothes skin. (afrugalchick.com)
  • Key Ingredient: Snail Secretion Filtrate contains "Mucin"- an EFFECTIVE ingredient for enhanced moisturization. (afrugalchick.com)
  • If you're a skincare enthusiast, you may have heard of snail mucin or snail secretion filtrate. (skinonyms.com)
  • Snail mucin, also known as snail slime, snail secretion filtrate, or snail mucus, is a gel-like substance produced by snails to protect and repair their skin. (skinonyms.com)
  • Snail mucin adalah lendir ekskresi yang dikeluarkan oleh siput saat stres dan dikenal juga sebagai snail secretion filtrat atau SSF. (rankbeauty.id)
  • Formulated with snail mucin and 10,000ppm of snail secretion filtrate to hydrate and regenerate skin, COSRX - Advanced Snail Mucin Gel Cleanser effectively removes impurities and creates a smoother complexion. (thekshop.ca)
  • Snail mucin, also known as snail secretion filtrate, is a popular skincare ingredient known for its hydrating, soothing, and anti-aging properties. (cleanbeautycoach.com)
  • Furthermore, the enhanced airway mucins in the MyD88- deficient mice were not due to defective secretion, as the mucin secretory capacity of MyD88-KO mice remained intact. (cdc.gov)
  • The MUC7 gene belongs to a group of genes encoding soluble mucin glycoproteins. (benthamscience.com)
  • Snail mucin contains hyaluronic acid, glycolic acid and glycoproteins which all have properties that benefit your skin," Leer says. (wivb.com)
  • The upper layer of the colonic mucus is a niche for a subset of the microbiota which utilise the mucin glycoproteins as a nutrient source and mucin grazing by the microbiota appears to play a key role in maintaining barrier function as well as community stability. (biorxiv.org)
  • The hyaluronic acid found in snail mucin hydrates the skin and helps with fine line and wrinkles. (wivb.com)
  • This cream moisturizer is powered by snail mucin, hyaluronic acid, and betaine to strengthen the skin barrier by replenishing moisture. (afrugalchick.com)
  • Hyaluronic acid is another important component of snail mucin. (skinonyms.com)
  • If you're looking for a vegan alternative to snail mucin, hyaluronic acid is a great option. (skinonyms.com)
  • If you follow skin care trends, you may have noticed products containing snail mucin gaining popularity as of late. (wivb.com)
  • If you're not sure whether you're allergic to shellfish or snail mucin, talk to your doctor before using any products containing snail mucin. (skinonyms.com)
  • We named this substance, which is common in jellyfish and similar to the human mucin MUC5AC, "qniumucin" and suggested the utilization of this compound as a new marine resource. (figshare.com)
  • The MUC5AC Antibody detects for mucin 5AC (MUC5AC), a secretory-type mucin found in columnar mucous cells of surface gastric epithelium, in goblet cells of the fetal, and in precancerous colon, but is not found in normal colon cells. (neuromics.com)
  • Overexpression of the mucin proteins, especially MUC1, is associated with many types of cancer. (wikipedia.org)
  • Some EGF-like mucins, plus MUC1 and MUC16, carry SEA domains, a vertebrate invention. (wikipedia.org)
  • This review discusses the emerging roles of mucins such as MUC1 and MUC4 in cancer and some other diseases, and stresses how underglycosylated and truncated mucins are exploited as markers of disease and to monitor widespread metastasis, making them useful in patient management. (bmj.com)
  • Mucin-1 kidney disease, previously described as medullary cystic kidney disease type 1 (MCKD1, OMIM 174000), is an autosomal dominant tubulointerstitial kidney disease recently shown to be caused by a single-base insertion within the variable number tandem repeat region of the MUC1 gene. (mit.edu)
  • The Role of the Cell Surface Mucin MUC1 as a Barrier to Infection and Regulator of Inflammation.Front Cell Infect Microbiol 24;9:117. (immuquest.com)
  • The MUC1 gene provides instructions for making a protein called mucin 1. (medlineplus.gov)
  • Typically, the most effective snail mucin products are found in a serum," Leer says. (wivb.com)
  • The COSRX Advanced Snail 96 Mucin Power Essence is among the most popular snail mucin products today. (kryzuy.com)
  • Changes in the sequence of glycosylation of mucins in different settings generate a variety of epitopes in the oligosaccharide side chains of mucins, including newly expressed blood-group antigens, distinguishing between normal and diseased states. (bmj.com)
  • Here we describe the discovery and characterisation of endo-acting family 16 glycoside hydrolases (GH16s) from prominent mucin degrading gut bacteria that specifically target the oligosaccharide side chains of intestinal mucins from both animals and humans. (biorxiv.org)
  • Although some mucins are membrane-bound due to the presence of a hydrophobic membrane-spanning domain that favors retention in the plasma membrane, most mucins are secreted as principal components of mucus by mucous membranes or are secreted to become a component of saliva. (wikipedia.org)
  • We have examined surface-functionalized gold nanoparticles (Au NPs) within mucin/mucus matrices to gain a better understanding of the mechanical and chemical interactions, as these systems are model nanoparticle-based therapeutics. (confex.com)
  • In addition, we have examined the bulk rheological effects for synthetic mucus solutions-based on pig gastric mucin (PGM) and different stabilizers-in response to GC-Au nanoparticle addition at different concentrations. (confex.com)
  • Salivary mucins, key components of mucus, actively protect the teeth from the cariogenic bacterium, Streptococcus mutans , according to research published ahead of print in Applied and Environmental Microbiology . (soladentalspa.com)
  • There is increasing evidence that mucins aren't just part of the mucus for structure or physical protection, but that they play an active role in protecting the host from pathogens and maintaining a healthy microbial environment. (soladentalspa.com)
  • This protein is one of several mucin proteins that make up mucus, a slippery substance that lubricates and protects the lining of the airways, digestive system, reproductive system, and other organs and tissues. (medlineplus.gov)
  • In addition to its role in mucus, mucin 1 is involved in cell signaling and kidney development. (medlineplus.gov)
  • It is unclear whether this points to a common origin among these transmembrane mucins. (wikipedia.org)
  • A transmembrane mucin that is found in a broad variety of epithelial tissue. (uams.edu)
  • Almasmoum H. The Roles of Transmembrane Mucins Located on Chromosome 7q22.1 in Colorectal Cancer.Cancer Manag Res. (immuquest.com)
  • MUC5B, the predominant mucin in the mouth and female genital tract, has been shown to significantly reduce attachment and biofilm formation of Streptococcus mutans, a bacterium with the potential to form cavities. (wikipedia.org)
  • Similar effects of MUC5B and other mucins have been demonstrated with other pathogens, such as Candida albicans, Helicobacter pylori, and even HIV. (wikipedia.org)
  • The studies, combined with mucin gene resequencing, homed in on a SNP in the putative promoter of MUC5B , 3 kb upstream of the transcription start site. (genengnews.com)
  • We focused on the effect of the salivary mucin, MUC5B on S. mutans attachment and biofilm formation because these are two key steps necessary for cavities to form," says Frenkel. (soladentalspa.com)
  • Hereditary Mucin Deficiency Caused by Biallelic Loss of Function of MUC5B . (bvsalud.org)
  • ODE primarily increased mucin (Muc)5ac levels relative to Muc5b. (cdc.gov)
  • Dermatologist Dr. Rosemarie Ingleton also advised via Elle to treat snail mucin as an additional step to skin hydration. (women.com)
  • This can help to minimize any potential irritation from the retinol and provide additional hydration and soothing benefits from the snail mucin. (cleanbeautycoach.com)
  • Sheet mask dipped in 35,000 ppm of snail mucin delivers nourishment and hydration skin deep! (co.ke)
  • Here, we focus on the salivary mucin-7 gene ( MUC7 ) to study the evolution and functional impact of subexonic repeats. (nature.com)
  • MUC7 provides an opportunity to assess the broader implications of subexonic repeat variation within the context of the functional evolution of the mucin functional group and primate salivary adaptation. (nature.com)
  • Mucin MUC7, Mucins - Potential Regulators of Cell Functions Volume Title: Gel-Forming and Soluble Mucins (2013) 1: 398. (benthamscience.com)
  • We extracted a novel glycoprotein, a member of the mucin family, from five species of jellyfish with high yields (1%−3% dry weight, 0.02%−0.1% wet weight) and determined its main chain structure and molecular mass. (figshare.com)
  • Despite the importance of mucin breakdown for gut health, the mechanisms by which gut bacteria access this complex glycoprotein are not well understood. (biorxiv.org)
  • P - selectin glycoprotein ligand - 1 (PSGL - 1) is a mucin - type protein that is heavily substituted with O - glycans. (avhandlingar.se)
  • A glycoprotein that forms mucin. (wordinfo.info)
  • Human mucins include genes with the HUGO symbol MUC 1 through 22. (wikipedia.org)
  • Mucin genes encode mucin monomers that are synthesized as rod-shaped apomucin cores that are post-translationally modified by exceptionally abundant glycosylation. (wikipedia.org)
  • Before we look at how snail mucin works, it's worth mentioning that COSRX and other brands that work with snail mucin say no snails are harmed. (metro.co.uk)
  • We even tried snail mucin, with Metro's Jess Lindsay enthusing she's noticed an improvement in glow and texture since using COSRX Advanced Snail 96 Mucin Power Essence Gel (£12) for the last month. (metro.co.uk)
  • Right now Prime Members can grab this COSRX Snail Mucin 92% Moisturizer 3.52 oz, Daily Repair Face Gel Cream at it's lowest price ever- under $10. (afrugalchick.com)
  • This COSRX Advanced Snail 96 Mucin Power Essence proves to be one of the brand's star products. (kryzuy.com)
  • The present study demonstrates that AZM and MDM suppress the synthesis of mucin and TNF-α from human airway epithelial cells. (karger.com)
  • Rationale Mucin homeostasis is fundamental to airway health . (bvsalud.org)
  • Although it is more than 90% water (per The Conversation ), Byrdie lists the following as its components: allantoin, zinc, manganese, copper peptides, glycolic acid, and vitamins A and E. These ingredients help make snail mucin a "mega multi-tasker" that addresses various skin concerns. (women.com)
  • Trefoil peptides may form dimers with each other, or associate with MUCINS and other factors. (bvsalud.org)
  • When researching or shopping for snail mucin-based skin care products, look for brands that harvest snail mucin in a safe and environmentally friendly fashion that doesn't harm any snails in the process. (wivb.com)
  • NO Snails are Harmed: Snail Mucin is obtained in a safe and environmentally friendly way in a favorite environment of snails and then processed as a cosmetic material. (afrugalchick.com)
  • The study grew out of previous work in the investigators' laboratory showing that other types of mucins, such as porcine gastric mucins, had protective effects against common lung pathogens, says Frenkel. (soladentalspa.com)
  • If you're curious to see how it works for your skin, start with a water-based snail mucin essence, as cosmetic chemist Georgia Smith suggested to Everyday Health , before leveling up to serums with their higher concentrations. (women.com)
  • It's important to note that snail mucin does not contain SPF, so you'll still need to apply sunscreen to protect your skin from the sun's harmful UV rays. (skinonyms.com)
  • Some people might find the snail mucin element a little gross, but having ADORED Elizavecca's Milky Piggy EGF Elastic Retinol Cream (which has literal bird's nest extract as the main ingredient) I'm picking up whatever the K-beauty world is putting down. (metro.co.uk)
  • Snail mucin can be found in a wide variety of skin care products, so there are many ways to incorporate this ingredient into your skin care routine. (wivb.com)
  • If you're new to the world of skincare, you might be wondering what snail mucin is and why it's become such a popular ingredient. (skinonyms.com)
  • Today, snail mucin is a popular ingredient in many skincare products. (skinonyms.com)
  • Menurut Desai-Solomon, tidak ada dokumentasi laporan yang menyebutkan tentang efek samping snail mucin. (rankbeauty.id)
  • Snail Mucin: Where Does The Product Fit In Your Skincare Routine? (women.com)
  • When using both snail mucin and retinol in your skincare routine, it is important to consider a few factors. (cleanbeautycoach.com)
  • In terms of incorporating snail mucin and retinol into your routine, you can apply snail mucin as a hydrating serum or moisturizer in your skincare routine, either in the morning or evening. (cleanbeautycoach.com)
  • If you're thinking of incorporating snail mucin in your skincare routine, START HERE! (kryzuy.com)
  • The snails are not harmed during the extraction process, which involves gently collecting the mucin from their slime trail. (skinonyms.com)
  • These repeats can be particularly well studied in this gene because the repeats are relatively short and few in number compared to other mucins. (nature.com)
  • These insertions occur in one particular region of the gene, the part that provides instructions for the repeating mucin domain. (medlineplus.gov)
  • Characterization of human mucin MUC17. (nih.gov)
  • Unconventional ingredients are used as well, including snail mucin, also known as snail slime or snail excretion. (women.com)
  • Tumour-associated epitopes on mucins and their antigenicity make them suitable as immunotargets on malignant epithelial cells and their secretions, creating a surge of interest in mucins as diagnostic and prognostic markers for various diseases, and even influencing the design of mucin-based vaccines. (bmj.com)
  • To evaluate the effect of multipurpose contact lens care solutions (MPSs) on membrane-associated mucins (Muc 1 & 16) expressions in the cornea using SV40 transformed Human corneal epithelial Cells (HCET) and Rat cornea tissue sections. (arvojournals.org)
  • Since the Korean brand, Missha, first introduced its Super Aqua Cell Renew Snail Cream , which claims to have 70% snail slime extract, the use of snail mucin has expanded to serums, face masks, and cleansers. (women.com)
  • The data suggest a new paradigm for mucin breakdown by the microbiota and the endo-mucinases provide a potential tool to explore changes that occur in mucin structure in intestinal disorders such as inflammatory bowel disease and colon cancer. (biorxiv.org)
  • Dermatologist Dr. Ted Lain told Byrdie that this harvesting process infuses snail mucin with the ingredients that contribute to its skin-repairing and protecting capacity. (women.com)
  • Like all skin care ingredients, certain individuals may have allergies, but there is nothing specific in snail mucin that leads to irritation or adverse outcomes," Leer says. (wivb.com)
  • Western blot was also used to analyze the effect of 0.1% macrogolglycerol hydroxystearate (HCO), 0.1% poloxamer, 0.1% poloxamine, 5 pm polyaminopropyl biguanide (PHMB), 0.05% boric acid, and 0.1% boric acid, common MPSs ingredients, on membrane-associated mucins (Muc 1 and Muc 16 ) expressions in HCET after 24 hours treatment. (arvojournals.org)
  • To use both ingredients together, you can apply snail mucin first, allowing it to fully absorb into the skin, and then follow with your retinol product. (cleanbeautycoach.com)
  • The multivalent mucins could adsorb chain type - sp ecific anti - A antibodies, which indicate a prospective use of the mucins in immunoadsorption (IA) columns. (avhandlingar.se)
  • Mucins (/ˈmjuːsɪn/) are a family of high molecular weight, heavily glycosylated proteins (glycoconjugates) produced by epithelial tissues in most animals. (wikipedia.org)
  • Furthermore the type, pattern and amount of mucin secreted in some tissues have been considered in the classification and terminology of neoplasia and in specific organs such as the pancreas. (bmj.com)
  • In the mouth, mucins can also recruit anti-microbial proteins such as statherins and histatine 1, which further reduces risk of infection. (wikipedia.org)
  • The dense "sugar coating" of mucins gives them considerable water-holding capacity and also makes them resistant to proteolysis, which may be important in maintaining mucosal barriers. (wikipedia.org)
  • This photomicrograph of a hematoxylin-eosin (H&E)-stained colonic mucosa specimen revealed some of the ultrastructural changes brought on by a generalized inflammatory reaction, including mucosal glands that were filled with mucin and inflammatory cells. (cdc.gov)
  • Also note that the mucosal epithelial crypts were filled with this over-production of mucin. (cdc.gov)
  • Of these mucins, the following classes have been defined by localization: Secreted mucins in humans, with their chromosomal location, repeat size in amino acids (aa), whether they are gel-forming (Y) or not (N), and their tissue expression. (wikipedia.org)
  • This protein is modified by the addition of numerous chains of sugar molecules, which are attached to certain amino acids in the mucin domain. (medlineplus.gov)
  • The mucin - type protein was used as a probe to analyze the O - glycosylation capacity of the se cell lines, which today are used for the commercial production of recombinant proteins and vaccine co mponents. (avhandlingar.se)
  • Presence of mucin in the urine, suggesting vaginal contamination. (wordinfo.info)
  • Excessive mucin production is characteristic of an inflammatory reaction. (cdc.gov)
  • PSGL - 1 genetically fused to mouse IgG 2b Fc forms a dimeric PSGL - 1/mIgG 2b mucin - type fusion protein. (avhandlingar.se)
  • Mucin-4 may play a role in regulating cellular adhesion and in cell surface signaling from the ERBB-2 RECEPTOR PROTEIN-TYROSINE KINASE. (uams.edu)
  • Collagen is a protein that is essential for maintaining skin elasticity and firmness, and snail mucin contains collagen-like proteins that can help to improve skin texture and reduce the appearance of wrinkles. (skinonyms.com)
  • These mutations lead to the production of an altered mucin 1 protein, although it is unclear how this change causes kidney disease. (medlineplus.gov)
  • N-linked oligosaccharides are also found on mucins, but in less abundance than O-linked sugars. (wikipedia.org)
  • With increasing interest on mucins as diagnostic and therapeutic targets in cancers and other diseases, it is becoming imperative to characterize novel mucins and investigate their biological significance. (nih.gov)
  • Defects in mucin production have been linked to common diseases such as asthma, cystic fibrosis, and ulcerative colitis," says Frenkel. (soladentalspa.com)
  • Glycolic acid is also present in snail mucin, which is an alpha-hydroxy acid (AHA) that helps to exfoliate dead skin cells and promote cell turnover. (skinonyms.com)
  • The mucin is then collected and processed for cosmetic use. (metro.co.uk)
  • By varying pH, complexation time, concentration, and temperature, the stability of the mucin-chitosan Au nanoparticle complexes was evaluated. (confex.com)
  • Multipurpose solutions' composition should be clinically controlled because Mucins play a very important role in the ocular surface integrity maintenance and the tear film stability. (arvojournals.org)
  • Mucins are highly glycosylated proteins that serve a variety of roles in organisms from lubrication to cell-signaling to defense 7 . (nature.com)
  • After confirming the successful synthesis of GC-Au nanoparticles, mucin aliquots were added to the GC-Au nanoparticle solution. (confex.com)
  • Additionally, snail mucin has humectants that keep your skin hydrated and antioxidants which improve the skin's protective barrier. (wivb.com)
  • Snail mucin is also rich in antioxidants, which can help to improve the skin's protective barrier and prevent damage from environmental stressors. (skinonyms.com)
  • So, what's in snail mucin that makes it great for skin? (metro.co.uk)
  • What is snail mucin skin care and why is everyone buying it? (wivb.com)
  • Why is snail mucin thought to be good for skin? (wivb.com)
  • Snail mucin has anti-aging effects, as it increases the generation of collagen, which makes your skin look more youthful," Leer adds. (wivb.com)
  • Snail mucin has also been used for centuries in traditional medicine to treat a variety of skin conditions, such as acne, scars, and wrinkles. (skinonyms.com)
  • Proteins are the building blocks of the skin, and snail mucin contains a variety of proteins that help to repair and regenerate damaged skin cells. (skinonyms.com)
  • A daily nourishing sheet mask formulated with Collagen extract and Phyto Mucin 5 complex to restore moisture in dehydrated skin while delivering vitality care. (lamisebeauty.com)
  • Snail mucin REALLY changed the skin care game with its many advantages. (kryzuy.com)
  • Membrane-associated mucins are one of the major components of the ocular surface that play a vital role in the maintenance of the ocular surface integrity. (arvojournals.org)
  • If you are vegan, you will be wondering if there is an alternative out there that will fulfill the same role as snail mucin without being an animal product. (skinonyms.com)
  • With this in mind, they suspected that salivary mucins would play a protective role, but they were not sure what that would be. (soladentalspa.com)
  • In addition, mucin 1 is present in cells that form the kidneys and is thought to play a role in development of these organs. (medlineplus.gov)
  • Because of variable age of disease onset and often subtle signs and symptoms, clinical diagnosis of mucin-1 kidney disease and differentiation from other forms of hereditary kidney disease have been difficult. (mit.edu)
  • The current model for mucin degradation involves exclusively exo-acting glycosidases that sequentially trim monosaccharides from the termini of the glycan chains to eventually allow access to the mucin peptide backbone by proteases. (biorxiv.org)
  • Mucin-4 is a heterodimer of alpha and beta chains. (uams.edu)
  • Meski begitu, ahli dermatologi lainnya mengatakan bahwa snail mucin sama seperti bahan lain yang bisa memicu alergi. (rankbeauty.id)
  • Mucins have been found to have important functions in defense against bacterial and fungal infections. (wikipedia.org)
  • We found that salivary mucins don't alter S. mutans ' growth or lead to bacterial killing over 24 hours," says Frenkel. (soladentalspa.com)
  • In particular, mucin 1 is found in the respiratory tract, female reproductive organs, and gastrointestinal tract. (medlineplus.gov)