Antineoplastic agent that is also used as a veterinary anesthetic. It has also been used as an intermediate in organic synthesis. Urethane is suspected to be a carcinogen.
Tumors or cancer of the LUNG.
A benign epithelial tumor with a glandular organization.
Family of retrovirus-associated DNA sequences (ras) originally isolated from Harvey (H-ras, Ha-ras, rasH) and Kirsten (K-ras, Ki-ras, rasK) murine sarcoma viruses. Ras genes are widely conserved among animal species and sequences corresponding to both H-ras and K-ras genes have been detected in human, avian, murine, and non-vertebrate genomes. The closely related N-ras gene has been detected in human neuroblastoma and sarcoma cell lines. All genes of the family have a similar exon-intron structure and each encodes a p21 protein.
Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
Pathological processes involving any part of the LUNG.
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
A cell line derived from cultured tumor cells.
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
A malignant epithelial tumor with a glandular organization.
The total amount (cell number, weight, size or volume) of tumor cells or tissue in the body.
Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
A class of compounds that contain a -NH2 and a -NO radical. Many members of this group have carcinogenic and mutagenic properties.
Damage to any compartment of the lung caused by physical, chemical, or biological agents which characteristically elicit inflammatory reaction. These inflammatory reactions can either be acute and dominated by NEUTROPHILS, or chronic and dominated by LYMPHOCYTES and MACROPHAGES.
A usually small, slow-growing neoplasm composed of islands of rounded, oxyphilic, or spindle-shaped cells of medium size, with moderately small vesicular nuclei, and covered by intact mucosa with a yellow cut surface. The tumor can occur anywhere in the gastrointestinal tract (and in the lungs and other sites); approximately 90% arise in the appendix. It is now established that these tumors are of neuroendocrine origin and derive from a primitive stem cell. (From Stedman, 25th ed & Holland et al., Cancer Medicine, 3d ed, p1182)
Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor genes are inactivated or lost, a barrier to normal proliferation is removed and unregulated growth is possible.
Small polyhedral outpouchings along the walls of the alveolar sacs, alveolar ducts and terminal bronchioles through the walls of which gas exchange between alveolar air and pulmonary capillary blood takes place.
The transference of either one or both of the lungs from one human or animal to another.
An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)
Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
A malignant kidney tumor, caused by the uncontrolled multiplication of renal stem (blastemal), stromal (STROMAL CELLS), and epithelial (EPITHELIAL CELLS) elements. However, not all three are present in every case. Several genes or chromosomal areas have been associated with Wilms tumor which is usually found in childhood as a firm lump in a child's side or ABDOMEN.
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
Tumors whose cells possess secretory granules and originate from the neuroectoderm, i.e., the cells of the ectoblast or epiblast that program the neuroendocrine system. Common properties across most neuroendocrine tumors include ectopic hormone production (often via APUD CELLS), the presence of tumor-associated antigens, and isozyme composition.
A di-tert-butyl PHENOL with antioxidant properties.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).
Proteins that are normally involved in holding cellular growth in check. Deficiencies or abnormalities in these proteins may lead to unregulated cell growth and tumor development.
Transplantation between animals of different species.
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
A pathologic process consisting of the proliferation of blood vessels in abnormal tissues or in abnormal positions.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.
Experimental transplantation of neoplasms in laboratory animals for research purposes.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.
A carcinoma thought to be derived from epithelium of terminal bronchioles, in which the neoplastic tissue extends along the alveolar walls and grows in small masses within the alveoli. Involvement may be uniformly diffuse and massive, or nodular, or lobular. The neoplastic cells are cuboidal or columnar and form papillary structures. Mucin may be demonstrated in some of the cells and in the material in the alveoli, which also includes denuded cells. Metastases in regional lymph nodes, and in even more distant sites, are known to occur, but are infrequent. (From Stedman, 25th ed)
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Washing liquid obtained from irrigation of the lung, including the BRONCHI and the PULMONARY ALVEOLI. It is generally used to assess biochemical, inflammatory, or infection status of the lung.
DNA present in neoplastic tissue.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.
In vivo methods of screening investigative anticancer drugs, biologic response modifiers or radiotherapies. Human tumor tissue or cells are transplanted into mice or rats followed by tumor treatment regimens. A variety of outcomes are monitored to assess antitumor effectiveness.
Experimentally induced mammary neoplasms in animals to provide a model for studying human BREAST NEOPLASMS.
The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.
The mucous membrane lining the RESPIRATORY TRACT, including the NASAL CAVITY; the LARYNX; the TRACHEA; and the BRONCHI tree. The respiratory mucosa consists of various types of epithelial cells ranging from ciliated columnar to simple squamous, mucous GOBLET CELLS, and glands containing both mucous and serous cells.
Established cell cultures that have the potential to propagate indefinitely.
A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.
A carcinoma discovered by Dr. Margaret R. Lewis of the Wistar Institute in 1951. This tumor originated spontaneously as a carcinoma of the lung of a C57BL mouse. The tumor does not appear to be grossly hemorrhagic and the majority of the tumor tissue is a semifirm homogeneous mass. (From Cancer Chemother Rep 2 1972 Nov;(3)1:325) It is also called 3LL and LLC and is used as a transplantable malignancy.
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
The milieu surrounding neoplasms consisting of cells, vessels, soluble factors, and molecules, that can influence and be influenced by, the neoplasm's growth.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.
The larger air passages of the lungs arising from the terminal bifurcation of the TRACHEA. They include the largest two primary bronchi which branch out into secondary bronchi, and tertiary bronchi which extend into BRONCHIOLES and PULMONARY ALVEOLI.
Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
Elements of limited time intervals, contributing to particular results or situations.
A form of highly malignant lung cancer that is composed of small ovoid cells (SMALL CELL CARCINOMA).
Three-dimensional computed tomographic imaging with the added dimension of time, to follow motion during imaging.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Agents that reduce the frequency or rate of spontaneous or induced tumors independently of the mechanism involved.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
Infection of the lung often accompanied by inflammation.
Experimentally induced tumor that produces MELANIN in animals to provide a model for studying human MELANOMA.
The relationship between the dose of an administered drug and the response of the organism to the drug.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Antibodies produced by a single clone of cells.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
Tumor suppressor genes located on the short arm of human chromosome 17 and coding for the phosphoprotein p53.
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
Tumors or cancer of the COLON.
A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.
A nitrosourea compound with alkylating, carcinogenic, and mutagenic properties.
Tumors or cancer of the LIVER.
Water content outside of the lung vasculature. About 80% of a normal lung is made up of water, including intracellular, interstitial, and blood water. Failure to maintain the normal homeostatic fluid exchange between the vascular space and the interstitium of the lungs can result in PULMONARY EDEMA and flooding of the alveolar space.
The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
A sarcoma derived from deep fibrous tissue, characterized by bundles of immature proliferating fibroblasts with variable collagen formation, which tends to invade locally and metastasize by the bloodstream. (Stedman, 25th ed)
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
All tumors in the GASTROINTESTINAL TRACT arising from mesenchymal cells (MESODERM) except those of smooth muscle cells (LEIOMYOMA) or Schwann cells (SCHWANNOMA).
Measurement of the amount of air that the lungs may contain at various points in the respiratory cycle.
Experimentally induced neoplasms of CONNECTIVE TISSUE in animals to provide a model for studying human SARCOMA.
Addition of methyl groups to DNA. DNA methyltransferases (DNA methylases) perform this reaction using S-ADENOSYLMETHIONINE as the methyl group donor.
The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.
Cellular proteins encoded by the H-ras, K-ras and N-ras genes. The proteins have GTPase activity and are involved in signal transduction as monomeric GTP-binding proteins. Elevated levels of p21 c-ras have been associated with neoplasia. This enzyme was formerly listed as EC
Plutonium. A naturally radioactive element of the actinide metals series. It has the atomic symbol Pu, atomic number 94, and atomic weight 242. Plutonium is used as a nuclear fuel, to produce radioisotopes for research, in radionuclide batteries for pacemakers, and as the agent of fission in nuclear weapons.
A tumor of undifferentiated (anaplastic) cells of large size. It is usually bronchogenic. (From Dorland, 27th ed)
Tumors or cancers of the KIDNEY.
Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.
Tumors or cancer of the SKIN.
Malignant neoplasm arising from the epithelium of the BRONCHI. It represents a large group of epithelial lung malignancies which can be divided into two clinical groups: SMALL CELL LUNG CANCER and NON-SMALL-CELL LUNG CARCINOMA.
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.
DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Substances and drugs that lower the SURFACE TENSION of the mucoid layer lining the PULMONARY ALVEOLI.
Tumors or cancer of the BRONCHI.
A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
The combination of two or more different factors in the production of cancer.
A radiological stereotactic technique developed for cutting or destroying tissue by high doses of radiation in place of surgical incisions. It was originally developed for neurosurgery on structures in the brain and its use gradually spread to radiation surgery on extracranial structures as well. The usual rigid needles or probes of stereotactic surgery are replaced with beams of ionizing radiation directed toward a target so as to achieve local tissue destruction.
A diverse group of lung diseases that affect the lung parenchyma. They are characterized by an initial inflammation of PULMONARY ALVEOLI that extends to the interstitium and beyond leading to diffuse PULMONARY FIBROSIS. Interstitial lung diseases are classified by their etiology (known or unknown causes), and radiological-pathological features.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
The excision of lung tissue including partial or total lung lobectomy.
Techniques and strategies which include the use of coding sequences and other conventional or radical means to transform or modify cells for the purpose of treating or reversing disease conditions.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
A pulmonary surfactant associated protein that plays a role in alveolar stability by lowering the surface tension at the air-liquid interface. It is a membrane-bound protein that constitutes 1-2% of the pulmonary surfactant mass. Pulmonary surfactant-associated protein C is one of the most hydrophobic peptides yet isolated and contains an alpha-helical domain with a central poly-valine segment that binds to phospholipid bilayers.
A transplantable, poorly differentiated malignant tumor which appeared originally as a spontaneous breast carcinoma in a mouse. It grows in both solid and ascitic forms.
Inhaling and exhaling the smoke of burning TOBACCO.
Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.
A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
A steroid-inducible protein that was originally identified in uterine fluid. It is a secreted homodimeric protein with identical 70-amino acid subunits that are joined in an antiparallel orientation by two disulfide bridges. A variety of activities are associated with uteroglobin including the sequestering of hydrophobic ligands and the inhibition of SECRETORY PHOSPHOLIPASE A2.
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.
Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.
Excessive accumulation of extravascular fluid in the lung, an indication of a serious underlying disease or disorder. Pulmonary edema prevents efficient PULMONARY GAS EXCHANGE in the PULMONARY ALVEOLI, and can be life-threatening.
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
A contagious, neoplastic, pulmonary disease of sheep characterized by hyperplasia and hypertrophy of pneumocytes and epithelial cells of the lung. It is caused by JAAGSIEKTE SHEEP RETROVIRUS.
DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
One or more layers of EPITHELIAL CELLS, supported by the basal lamina, which covers the inner or outer surfaces of the body.
The exposure to potentially harmful chemical, physical, or biological agents by inhaling them.
The circulation of the BLOOD through the LUNGS.
A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2. It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors.
Round, granular, mononuclear phagocytes found in the alveoli of the lungs. They ingest small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells.
An imaging technique using compounds labelled with short-lived positron-emitting radionuclides (such as carbon-11, nitrogen-13, oxygen-15 and fluorine-18) to measure cell metabolism. It has been useful in study of soft tissues such as CANCER; CARDIOVASCULAR SYSTEM; and brain. SINGLE-PHOTON EMISSION-COMPUTED TOMOGRAPHY is closely related to positron emission tomography, but uses isotopes with longer half-lives and resolution is lower.
Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
RNA present in neoplastic tissue.
The loss of one allele at a specific locus, caused by a deletion mutation; or loss of a chromosome from a chromosome pair, resulting in abnormal HEMIZYGOSITY. It is detected when heterozygous markers for a locus appear monomorphic because one of the ALLELES was deleted.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
An abnormal increase in the amount of oxygen in the tissues and organs.
A family of non-enveloped viruses infecting mammals (MASTADENOVIRUS) and birds (AVIADENOVIRUS) or both (ATADENOVIRUS). Infections may be asymptomatic or result in a variety of diseases.
The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.
Tumors or cancer of the human BREAST.
Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.
A class of chemicals that contain an anthracene ring with a naphthalene ring attached to it.
Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
A carcinogen that is often used in experimental cancer studies.
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
A genetic rearrangement through loss of segments of DNA or RNA, bringing sequences which are normally separated into close proximity. This deletion may be detected using cytogenetic techniques and can also be inferred from the phenotype, indicating a deletion at one specific locus.
Colloids with a gaseous dispersing phase and either liquid (fog) or solid (smoke) dispersed phase; used in fumigation or in inhalation therapy; may contain propellant agents.
Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.
Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.
A rare but highly lethal childhood tumor found almost exclusively in infants. Histopathologically, it resembles RHABDOMYOSARCOMA but the tumor cells are not of myogenic origin. Although it arises primarily in the kidney, it may be found in other parts of the body. The rhabdoid cytomorphology is believed to be the expression of a very primitive malignant cell. (From Holland et al., Cancer Medicine, 3d ed, p2210)
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.
The administration of drugs by the respiratory route. It includes insufflation into the respiratory tract.
Experimentally induced tumors of the LIVER.
A product of the p16 tumor suppressor gene (GENES, P16). It is also called INK4 or INK4A because it is the prototype member of the INK4 CYCLIN-DEPENDENT KINASE INHIBITORS. This protein is produced from the alpha mRNA transcript of the p16 gene. The other gene product, produced from the alternatively spliced beta transcript, is TUMOR SUPPRESSOR PROTEIN P14ARF. Both p16 gene products have tumor suppressor functions.
Interruption or suppression of the expression of a gene at transcriptional or translational levels.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
Biochemical identification of mutational changes in a nucleotide sequence.
Computer-assisted mathematical calculations of beam angles, intensities of radiation, and duration of irradiation in radiotherapy.
Tumors or cancer located in bone tissue or specific BONES.
A neoplasm composed entirely of GRANULOSA CELLS, occurring mostly in the OVARY. In the adult form, it may contain some THECA CELLS. This tumor often produces ESTRADIOL and INHIBIN. The excess estrogen exposure can lead to other malignancies in women and PRECOCIOUS PUBERTY in girls. In rare cases, granulosa cell tumors have been identified in the TESTES.
Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.
Compounds that are used in medicine as sources of radiation for radiotherapy and for diagnostic purposes. They have numerous uses in research and industry. (Martindale, The Extra Pharmacopoeia, 30th ed, p1161)
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.
Agents and endogenous substances that antagonize or inhibit the development of new blood vessels.
Tumors or cancer of the MAMMARY GLAND in animals (MAMMARY GLANDS, ANIMAL).
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA.
The volume of air contained in the lungs at the end of a maximal inspiration. It is the equivalent to each of the following sums: VITAL CAPACITY plus RESIDUAL VOLUME; INSPIRATORY CAPACITY plus FUNCTIONAL RESIDUAL CAPACITY; TIDAL VOLUME plus INSPIRATORY RESERVE VOLUME plus functional residual capacity; or tidal volume plus inspiratory reserve volume plus EXPIRATORY RESERVE VOLUME plus residual volume.
Stable xenon atoms that have the same atomic number as the element xenon, but differ in atomic weight. Xe-124, 126, 128-131, 134, and 136 are stable xenon isotopes.
Endoscopic examination, therapy or surgery of the bronchi.
... the growth rate of tumors, and the tumor forming potential in triple negative breast cancer cell lines using mouse xenografts.[ ... For example, EMT has been associated with PD-L1 expression, particularly in lung cancer. Increased levels of PD-L1 suppresses ... Initiation of metastasis requires invasion, which is enabled by EMT.[36][37] Carcinoma cells in a primary tumor lose cell-cell ... 2007). "No evidence for mouse pancreatic beta-cell epithelial-mesenchymal transition in vitro". Diabetes. 56 (3): 699-702. doi: ...
The leuco form induces renal, hepatic and lung tumor in mice." Health Canada recently found medical devices that use gentian ... It is also sometimes used as a cheap way to put identification markings on laboratory mice; since many strains of lab mice are ... One study in mice demonstrated dose-related carcinogenic potential at several different organ sites. The Food and Drug ... "Chronic toxicity and carcinogenicity studies of gentian violet in mice", Fundam. Appl. Toxicol., 5 (5), pp. 902-912, doi: ...
Tumor suppressor candidate 3 is a protein that in humans is encoded by the TUSC3 gene. This gene is a candidate tumor ... "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. MacGrogan D, Levy A ... The gene is expressed in most nonlymphoid human tissues including prostate, lung, liver, and colon. Expression was also ... "Entrez Gene: TUSC3 tumor suppressor candidate 3". Pak BJ, Park H, Chang ER, et al. (1998). "Differential display analysis of ...
A549 cells - derived from a cancer patient lung tumor. HeLa cells - a widely used human cell line isolated from cervical cancer ... 3T3 cells - a mouse fibroblast cell line derived from a spontaneous mutation in cultured mouse embryo tissue. ...
... mice demonstrates reduced amount of tumors comparing to IRS-1 (+/+)/ Apc (min/+) mice. In lung adenocarcinoma cell line A549 ... Frequency of lung metastasis in IRS-1 deficient tumor is elevated opposing to IRS-2 deficient tumor, where it is decreased. ... Transgenic mice overexpressing IRS-1 develop metastatic breast cancer. The tumors demonstrate squamous differentiation which is ... Tumor infiltrating neutrophils have recently been thought to adjust tumor growth and invasiveness. Neutrophil elastase is shown ...
... is a putative tumor suppressor. Knockout studies in mice have shown an increase in tumor development when MDC1 is lost. ... Studies on lung cancer cell lines (A549 cells) showed an increase in apoptosis in response to genotoxic agents when MDC1 ... Mice lacking MDC1 are smaller, have infertile males, are radiosensitive, and are more susceptible to tumors. Knock out MDC1 ... "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. Ozaki T, Nagase T, ...
Said N, Sanchez-Carbayo M, Smith SC, Theodorescu D (April 2012). "RhoGDI2 suppresses lung metastasis in mice by reducing tumor ... "Tumor endothelin-1 enhances metastatic colonization of the lung in mouse xenograft models of bladder cancer". J. Clin. Invest. ... in their roles in tumor formation and spread of tumor to other organs (the process of metastasis). For example, RhoGDI2 ... "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. Lelias JM, Adra CN ...
Expression of RGS17 is required for maintenance of proliferation in lung tumor cell lines. GRCh38: Ensembl release 89: ... "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. Jordan JD, Carey KD ... RGS17 is a putative lung cancer susceptibility gene in the lung cancer associated locus on chromosome 6q in humans. RGS17 is ... James MA, Lu Y, Liu Y, Vikis HG, You M (Mar 2009). "RGS17, an overexpressed gene in human lung and prostate cancer, induces ...
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. Arakawa H, Nakamura ... The Pitx2 gene plays a role in lung adenocarcinoma that is dependent on activating the Wnt/β-catenin signaling pathway. When ... Experimental knockdown of Pixt2 repressed tumor growth of LUAD; this supports the claim that Pixt2 is associated with the ... Pitx2 is responsible for the establishment of the left-right axis, the asymmetrical development of the heart, lungs, and spleen ...
"Transforming Growth Factor-β1 overexpression in Tumor Necrosis Factor-α receptor knockout mice induces fibroproliferative lung ... Figure B shows lungs with asbestos-related diseases, including pleural plaque, lung cancer, asbestosis, plaque on the diaphragm ... Lower RT/lung disease. (including LRTIs). Bronchial/. obstructive. acute. Acute bronchitis. chronic. COPD Chronic bronchitis. ... lung disease. Pneumoconiosis Aluminosis. Asbestosis. Baritosis. Bauxite fibrosis. Berylliosis. Caplan's syndrome. Chalicosis. ...
Bu, Jieqiong; Yu, Baofa (Oct 2007). "Slow intra-tumor release od drugs on B16 melonoma in Mice". Journal of Shandong University ... Lung Cancer: Targets and Therapy. 6: 1-11. doi:10.2147/LCTT.S70679. PMC 5217516. PMID 28210146. Gao, Feng; Jing, Peng; Liu, ... Four years later, he graduated and landed a job in the Shandong Tumor Research Institute and transferred to the China Academy ... In 1985, Yu enrolled in Peking Union Medical College (tumour department) in Beijing to further his studies and received a ...
"Metastasis Suppressors Regulate the Tumor Microenvironment by Blocking Recruitment of Prometastatic Tumor-Associated ... "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. Jiao X, Nawab O, ... Human-to-human infection of bubonic plague does not occur, though it can occur in pneumonic plague, which infects the lungs. ... After infection with West Nile Virus, CCR5 Δ32 mice had markedly increased viral titers in the central nervous system and had ...
The EP2 receptor can act as a tumor promoter. EP2 gene knockout mice have less lung, breast, skin, and colon cancers following ... EP2 expression in fibroblasts from the lungs of mice with bleomycin-induced pulmonary fibrosis and humans with Idiopathic ... EP2-deficient mice exhibit impaired generation of osteoclasts (cells that break down bone tissue) due to a loss in the capacity ... EP2 receptor-deficient mice develop mild systolic and/or systemic hypertension which is worsened by high dietary intake of salt ...
Brown DM, Ruoslahti E (April 2004). "Metadherin, a cell surface protein in breast tumors that mediates lung metastasis". Cancer ... "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. "Entrez Gene: MTDH ... a cell surface protein in breast tumors that mediates lung metastasis". Cancer Cell. 5 (4): 365-74. doi:10.1016/S1535-6108(04) ... MTDH/AEG-1 induces hepato steatosis in mouse liver. The MTDH knockdown by artificial microRNA interference functions as a ...
hnRNPA2/B1 is found to activate cyclooxygenase-2 and promote tumor growth in human lung cancers. GRCh38: Ensembl release 89: ... "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. Biamonti G, Ruggiu ... hnRNPA2/B1 activates cyclooxygenase-2 and promotes tumor growth in human lung cancers, Molecular Oncology, 10, doi: 10.1016/j. ... QU XH, LIU JL, ZHONG XW, LI X, ZHANG QG (2015). "Insights into the roles of hnRNP A2/B1 and AXL in non-small cell lung cancer ...
In one animal study, mice that were fed coal tar developed lung tumors. DNA adducts in these mice were analyzed and could be ... Exposure to benzo[c]fluorene in vivo leads to the induction of mainly lung tumors where it acts as a DNA adductor. Lung tumors ... These adducts and the ones that were observed in lung tumors of mice were similar, which strengthens the hypothesis that human ... arise after topical application in mice with coal tar, but also when it is ingested. Next to its involvement in lung tumors, ...
This gene is a sensitive marker for neuroendocrine differentiation of human lung tumors. INSM1 has been shown to interact with ... "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. Lan MS, Li Q, Lu J ... Li Q, Notkins AL, Lan MS (July 1997). "Molecular characterization of the promoter region of a neuroendocrine tumor marker, IA-1 ... is a sensitive and highly specific marker of neuroendocrine differentiation in primary lung neoplasms: an immunohistochemical ...
... a candidate tumor suppressor gene at chromosome 22q12.1, deleted, mutated, and methylated in human lung cancer". Proc Natl Acad ... "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. Nishioka M, Kohno T ... 2004). "Reduced expression of MYO18B, a candidate tumor-suppressor gene on chromosome arm 22q, in ovarian cancer". Int. J. ... Mutations in this gene are associated with lung cancer. GRCh38: Ensembl release 89: ENSG00000133454 - Ensembl, May 2017 GRCm38 ...
For example, BjF is active as a tumor initiator on mouse skin and is carcinogenic in both mouse skin and in rat lungs. Recently ... In mice studies BjF induced tumorigenic activity on the skin, lung adenomas and liver adenomas/hepatomas. Lung implantation of ... BjF was also found to induce tumors in newborn mouse lung and liver. The mechanism of actions of BjF is similar to other PAHs. ... "Tumour initiating activity of dihydrodiols of benzo[b]fluoranthene, benzo[j]fluoranthene, and benzo[k]fluoranthene." ...
Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout ... High levels of Bcl-w are seen in many cancers, including glioblastoma, colorectal cancer, non-small-cell lung carcinoma, and ... Breast cancer patients with metastasis have higher Bcl-w than breast cancer patients only having primary tumor. Elevated levels ... "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. Gibson L, Holmgreen ...
Loss of Kaiso expression in breast tumor cells prevents intra-vascular invasion in mice lungs and secondary metastasis. (2017) ... The gene encoding p120cas, a novel catenin, localizes on human chromosome 11q11 (CTNND) and mouse chromosome 2 (Catns). (1996) ... Kaiso overexpression promotes intestinal inflammation and potentiates intestinal tumorigenesis in ApcMin/+ mice (2015) BBA- ...
Mice injected with melanoma cells with a deleted IRES display more aggressive tumor progression including increased lung ... "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. Lahn BT, Page DC ( ... the co-localization of these proteins has also been demonstrated in MDA-MB-231 xenograft tumor samples. In HeLa cells DDX3X is ... level of DDX3X is lower in matched post-relapse melanoma biopsies for patients receiving vemurafenib and in progressing tumors ...
... a Putative Mammalian Homeotic Gene Differentially Expressed in Small Cell Lung Carcinoma and Neuroendocrine Tumor Cell Line". ... "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. Laborda J, ... A Novel Circulating Human Epidermal-Growth-Factor-Like Protein Expressed in Neuroendocrine Tumors and its Relation to the Gene ...
... is a key upregulated factor in lung squamous cell carcinoma, directing many genes involved in tumor progression. Sox2 ... "Sox2 cooperates with Lkb1 loss in a mouse model of squamous cell lung cancer". Cell Reports. 8 (1): 40-9. doi:10.1016/j.celrep. ... "Serological identification of embryonic neural proteins as highly immunogenic tumor antigens in small cell lung cancer". ... In lung development, Sox2 controls the branching morphogenesis of the bronchial tree and differentiation of the epithelium of ...
"Semaphorin7A promotes tumor growth and exerts a pro-angiogenic effect in macrophages of mammary tumor-bearing mice". Frontiers ... Tumor cell growth, EMT, lung metastasis and angiogenesis have been linked to increased Sema7a expression in murine models. ... Tumors increase SEMA7A expression in an involuting environment, but knockout of SEMA7a in mouse models undergoing involution ... Sema7A -/- mice show defects in olfactory tract development. In normal breast tissue, mRNA expression of SEMA7A is low or not ...
"Effects of GBS toxin on long-term survival of mice bearing transplanted Madison lung tumors". J. Cancer Res. Clin. Oncol. 120 ( ... The lung is the last organ to develop so HP59 is present in the newborn lung for 5-10 days after birth, explaining the ... and in tumor angiogenesis, as shown in mice. The gene for HP59 contains, entirely within its coding region, the Sialin Gene ... However capillaries in all tumor tissues examined were positive for anti-HP59 antibodies and Von Willebrand factor (vWF) ...
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. Rebbe NF, Hickman ... In salivary gland tumors, expression of HSP90AA1 and HSP90AB1 correlates with malignancy, proliferation and metastasis. The ... is a genetic disease with increased viscosity of various secretions leading to organ failure of lung, pancreas and other organs ... Hoffmann T, Hovemann B (Dec 1988). "Heat-shock proteins, Hsp84 and Hsp86, of mice and men: two related genes encode formerly ...
"Mouse mammary tumor virus p75 and p110 CUX1 transgenic mice develop mammary tumors of various histologic types". Cancer ... Metastasis to the lung was observed in three cases of mammary tumors expressing p75 CUX1. The mechanisms of action differ ... Tumors that develop in p200 CUX1 transgenic mice reveal a different mode of action, as 44% of these tumors harboured a ... CUX1 transgenic mice develop tumors in multiple organs and tissues after a long latency period. Transgenic mice expressing ...
1998). "Human lung cancer antigens recognized by autologous antibodies: definition of a novel cDNA derived from the tumor ... "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. Timmer T, Terpstra ... The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium". Cancer Res. 60 (21): 6116-33. PMID 11085536 ... 2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci ...
1 knockout mice leads to an inhibited cytokine response in granulomas associated with murine Taenia crassiceps infection". The ... a novel potent inhibitor of signal transduction and growth in vitro and in vivo in small cell lung cancer cells". Cancer ... a potential target for novel medicines in malignant brain tumour therapies (mini-review)". Folia Neuropathologica. 45 (3): 99- ... analgesia and aggression in mice lacking the receptor for substance P". Nature. 392 (6674): 394-7. doi:10.1038/32904. PMID ...
"Lung cancer as consequence by Benzopyrene in smokers". Lung Cancer. Archived from the original on April 14, 2005. Retrieved ... Experiments with strains of mice engineered to remove (knockout) CYP1A1 and CYP1B1 reveal that CYP1A1 primarily acts to protect ... This gene is a transcription factor that regulates the cell cycle and hence functions as a tumor suppressor. By inducing G ( ... BaP was shown to cause genetic damage in lung cells that was identical to the damage observed in the DNA of most malignant lung ...
"In Vivo Delivery of miR-34a Sensitizes Lung Tumors to Radiation Through RAD51 Regulation". Mol Ther Nucleic Acids. 4: e270. doi ... "Mouse PubMed Reference:".. *^ Shinohara A, Ogawa H, Ogawa T (May 1992). "Rad51 protein involved in repair and recombination in ... "Development of a lung cancer therapeutic based on the tumor suppressor microRNA-34". Cancer Res. 70 (14): 5923-30. doi:10.1158/ ... Non-small-cell lung cancer. Over-expression. 29%. Immunohistochemistry. [22]. Soft tissue sarcoma. Over-expression. 95%. ...
... lung, colon, and thyroid tissues as the most radiosensitive among women. For example, the FGR 13 has estimated that the ratio ... other solid tumor cancers, and leukemia. The relationship between radiation exposure and subsequent cancer risk is considered " ... "Increased genomic instability in somatic cells of the progeny of female mice exposed to acute X-radiation in the ... leukemia and certain solid tumors that have developed within a decade or more after exposure. As studies of biological samples ...
In the 1980s, while investigating nucleotide sequences in mouse genome loci, the Hogness box sequence was found and "boxed in" ... Gaillard J, Haguenauer JP, Romanet P, Boulud B, Gerard JP (November 1977). "[Tumors of the olfactory placode. Study of 5 cases ... lung cancer,[33] chronic hemolytic anemia,[34] immunosuppression,[35] hemophilia B Leyden,[36] and thrombophlebitis and ... "Nucleotide sequences of mouse genomic loci including a gene or pseudogene for U6 (4.8S) nuclear RNA". Nucleic Acids Research ...
E. Carleton MacDowell in 1928 discovered a strain of mouse called C58 that developed spontaneous leukemia - an early mouse ... In 2011, Wigler, James Hicks and Nick Navin perform the first genomic profile of single cancer cells from a patient's tumor;[42 ... Principal cancer types under study: breast, prostate, blood (leukemia, lymphoma); melanoma; liver; ovarian and cervical; lung; ... "Studies on Leukemia in Mice: I: The Experimental Transmission of Leukemia". J. Exp. Med. 51: 659-73. doi:10.1084/jem.51.4.659. ...
Amaral, André F. S.; Strachan, David P.; Real, Francisco Gómez; Burney, Peter G. J.; Jarvis, Deborah L. Lower lung function ... Impairment of BRCA1-related DNA double-strand break repair leads to ovarian aging in mice and humans. Science Translational ... 生殖腺(英语:Template:Gonadal tumors, paraganglioma, and glomus). *生殖細胞 ... Menopause is Associated with Accelerated Lung Function Decline. American Journal of Respiratory and Critical Care Medicine. ...
"Proof-of-concept study of biomarker development in mice provides a roadmap for a similar approach in humans". ... since mutant proteins can only come from an existing tumor, thus providing ultimately the best specificity for medical purposes ... and lung cancer, and in melanoma.[3] ...
Tumor development is a complex process that requires cell division, growth, and survival. One approach used by tumors to ... Both mouse and human in vivo models of HER2-overexpressing breast cancers relied critically on this HER2-IL-6-STAT3 signaling ... Several studies have outlined the importance of autocrine IL-6 signaling in lung and breast cancers. For example, one group ... Another group found that high serum levels of IL-6 correlated with poor outcome in breast cancer tumors. Their research showed ...
Zhao H, Jin S, Antinore MJ, Lung FD, Fan F, Blanck P, Roller P, Fornace AJ, Zhan Q. The central region of Gadd45 is required ... a potential mediator of p53 tumor suppression. „Cell". 75 (4), s. 817-25, 1993. DOI: 10.1016/0092-8674(93)90500-P. PMID: ... Lack of p21 expression links cell cycle control and appendage regeneration in mice. „Proceedings of the National Academy of ... a novel PCNA associated factor with increased expression in tumor tissues. „Oncogene". 20 (4), s. 484-9, 2001. DOI: 10.1038/sj. ...
As of 2018, there are about 20 TARDBP mouse models, a dozen FUS mouse models, and a number of C9orf72, PFN1, and UBQLN2 mouse ... As the diaphragm and intercostal muscles of the rib cage that support breathing weaken, measures of lung function such as vital ... such as a spinal cord tumor, multiple sclerosis, a herniated disk in the neck, syringomyelia, or cervical spondylosis.[4] ... the SOD1G93A model remains both the most widely used SOD1 mouse model[136] and the most widely used ALS mouse model overall.[23 ...
View/Edit Mouse. CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family and tumor ... "Entrez Gene: TNFRSF8 tumor necrosis factor receptor superfamily, member 8".. *^ Teng LH, Lu DH, Xu QZ, Fu YJ, Yang H, He ZL ( ... tumor necrosis factor-activated receptor activity. • nerve growth factor binding. Cellular component. • cytoplasm. • integral ... tumor necrosis factor-mediated signaling pathway. • axon guidance. • negative regulation of neuron projection development. • ...
By luck, this species did not make its own vitamin C, whereas mice and rats do.[174] In 1912, the Polish biochemist Casimir ... Evidence for ascorbate's anti-tumor effects was limited to case reports and observational and uncontrolled studies."[44] ... "Drugs for preventing lung cancer in healthy people". The Cochrane Database of Systematic Reviews. 10: CD002141. doi:10.1002/ ... to kill tumor cells. The same literature claims that ascorbic acid acts as an antioxidant, thereby reducing the adverse effects ...
Wang G, Sun J, Liu G, Fu Y, Zhang X (December 2017). "Bradykinin Promotes Cell Proliferation, Migration, Invasion, and Tumor ... Increased levels of bradykinins resulting from ACE inhibitor use have been associated with increased lung cancer risks[17] ... "Association between kinin B(1) receptor expression and leukocyte trafficking across mouse mesenteric postcapillary venules" ... "ACE inhibitors are linked to increased lung cancer risk, study finds". BMJ. 363: k4471. doi:10.1136/bmj.k4471. PMID 30355572 ...
Beutler B, Milsark IW, Cerami AC (August 1985). "Passive immunization against cachectin/tumor necrosis factor protects mice ... negative regulation of branching involved in lung morphogenesis. • JNK cascade. • death-inducing signaling complex assembly. • ... TNF, DIF, TNF-alpha, TNFA, TNFSF2, Tumour necrosis factor, TNF-α, tumor necrosis factor, TNLG1F, Tumor necrosis factor alpha. ... Tumor necrosis factor (TNF, tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a cell signaling protein (cytokine) ...
Lung Cellular and Molecular Physiology. 288 (5): L789-92. doi:10.1152/ajplung.00016.2005. PMID 15821019. Leger AJ, Covic L, ... Wojtukiewicz MZ, Tang DG, Ben-Josef E, Renaud C, Walz DA, Honn KV (Feb 1995). "Solid tumor cells express functional "tethered ... "Mouse PubMed Reference:". Bahou WF, Nierman WC, Durkin AS, Potter CL, Demetrick DJ (Sep 1993). "Chromosomal assignment of the ... which is important in the pathogenesis of inflammatory and fibrotic lung diseases. It is involved both in disruption and ...
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.. ... Non-small cell lung cancer Overexpression is associated with lymph node metastasis, high TNM stage and poor prognosis.[23] ... Tumour Biology. 34 (1): 107-14. doi:10.1007/s13277-012-0517-x. PMID 23001926. S2CID 12445919.. ... CASS4 function was linked to non-small cell lung cancer (NSCLC) in a study by Miao et al. that correlated elevated CASS4 ...
The effects against solid tumors of trastuzumab and rituximab monoclonal antibodies have been shown in experiments with mice to ... Furthermore, NK cells are involved in killing tumor cells and other cells that may lack MHC I on their surface, indicating a ... Clynes, RA; Towers, TL; Presta, LG; Ravetch, JV (2000). "Inhibitory Fc receptors modulate in vivo cytoxicity against tumor ... induces killing of multiple myeloma and other hematological tumors". J Immunol. 186 (3): 1840-8. doi:10.4049/jimmunol.1003032. ...
FcεRI is expressed on mast cells, basophils, and the antigen-presenting dendritic cells in both mice and humans. Binding of ... It is most likely beneficial in removal of hookworms from the lung. ... "Activity of human monocytes in IgE antibody-dependent surveillance and killing of ovarian tumor cells". Eur. J. Immunol. 33 (4 ... "Antibodies specific for a segment of human membrane IgE deplete IgE-producing B cells in humanized mice". J. Clin. Invest. 120 ...
"Mouse PubMed Reference:".. *^ Graham A, Heath P, Morten JE, Markham AF (March 1991). "The human aldose reductase gene maps to ... is associated with malignancy in human sporadic adrenocortical tumors". The Journal of Clinical Endocrinology and Metabolism. ... lung, and liver.[8] It is a reduced nicotinamide-adenine dinucleotide phosphate (NADPH)-dependent enzyme catalyzing the ... "Tonicity-responsive enhancer binding protein regulates the expression of aldose reductase and protein kinase C δ in a mouse ...
For technological advances that enabled development of HPV vaccines for prevention of cervical cancer and other tumors caused ... Development of a powerful technology for manipulating the mouse genome with exquisite precision, which allows the creation of ... 1980 - National Heart, Lung, and Blood Institute. *1984 - Dorothy T. Krieger. *1987 - Centennial Salute to the National ...
... this is thought to contribute to the seeding of tumor microemboli to distant organs.[22] In vivo mice experiment showed that ... first in vivo evidence for their crucial role in a clinically relevant model of spontaneous metastasis formation in the lung". ... "Mouse PubMed Reference:".. *^ Ryan US, Worthington RE (February 1992). "Cell-cell contact mechanisms". Curr. Opin. Immunol. 4 ( ... "Five tumor necrosis factor-inducible cell adhesion mechanisms on the surface of mouse endothelioma cells mediate the binding of ...
Tubercle and Lung Disease. 1994, roč. 75, čís. 2, s. 138-43. DOI:10.1016/0962-8479(94)90043-4. PMID 8032047.. ... Mutlu, G., Mutlu, E., Bellmeyer, A., Rubinstein, I. Pulmonary adverse events of anti-tumor necrosis factor-alpha antibody ... A pantothenate auxotroph of Mycobacterium tuberculosis is highly attenuated and protects mice against tuberculosis. Nature ... The International Journal of Tuberculosis and Lung Disease. 2003, roč. 7, čís. 4, s. 359-64. PMID 12733492.. ...
Nusse, R.; Varmus, H. E. (1982-11-01). "Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in ... characterization of mutations of the epidermal growth factor receptor gene in human lung cancers, including a common mutation ... "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib". Proceedings of the National Academy ... that confers drug resistance (with William Pao[18]); and generation of numerous mouse models of human cancer. Notably, Varmus ...
"Investigating Tumor Heterogeneity in Mouse Models". Annual Review of Cancer Biology. 4: 99-119. doi:10.1146/annurev-cancerbio- ... For example, rare specialized cells in the lung called pulmonary ionocytes that express the Cystic Fibrosis Transmembrane ... Fresh or frozen tumors may be analyzed and categorized with respect to SCNAs, SNVs, and rearrangements quite well using whole ... The NSR primers were carefully designed according to rRNA sequences in the specific organism (mouse), and designing new primer ...
"Human prostate tumor growth in athymic mice: inhibition by androgens and stimulation by finasteride". Proc. Natl. Acad. Sci. U. ... men after lung cancer. In the United Kingdom it is also the second most common cause of cancer death after lung cancer, where ... Tumor markers. Tissue samples can be stained for the presence of PSA and other tumor markers in order to determine the origin ... Eventually, the tumor may grow large enough to invade nearby organs such as the seminal vesicles or the rectum, or the tumor ...
... mouse astrocytes transfected to stably co-express both human PDGFRα and PDGF AA. The lung cancer cell line H1703, which is ... "Phase II Study of Crenolanib (CP-868,596), for the Treatment of Patients With Advanced Gastrointestinal Stromal Tumors With the ... Evaluation of the antitumor activity of crenolanib in a genetically engineered BSG DIPG mouse model showed that it is highly ... Östman, Arne; Heldin, Carl‐Henrik (2007). "PDGF Receptors as Targets in Tumor Treatment". Advances in Cancer Research. 97: 247- ...
... advanced lung disease and certain tumors.[43] A recent study done in Pondicherry, India, shows its importance in coronary ... For example, recent studies have suggested genetic variants in deer mice that help explain how deer mice that live in the ... Haemoglobin in the blood carries oxygen from the lungs or gills to the rest of the body (i.e. the tissues). There it releases ... After examining wild mice captured from both highlands and lowlands, it was found that: the genes of the two breeds are " ...
In mice, the nude mouse strain are congenitally thymic deficient. These mice are an important model of primary T cell ... 1985). "Thyroid Tumors Following Thymus Irradiation". J Natl Cancer Inst. 74 (6): 1177-1184. doi:10.1093/jnci/74.6.1177. PMID ... lung. This article incorporates text in the public domain from the 20th edition of Gray's Anatomy (1918) editor-in-chief, Susan ... A fully functional thymus derived from reprogrammed mouse embryonic fibroblasts has been grown in the kidney capsule of mice. ...
In this therapy, mice are immunized with the CD19 antigen and produce anti-CD19 antibodies. Hybridomas developed from mouse ... Medical imaging (such as ultrasound or CT scanning) can find invasion of other organs commonly the lung, liver, spleen, lymph ... Use high doses of chemotherapy to further reduce tumor burden Typical protocols use the following given as blocks (varies from ... August 2005). "Cytogenetic characterization of a BCR-ABL transduced mouse cell line". Cancer Genetics and Cytogenetics. 161 (1 ...
Ever since discovering a decade ago that a gene altered in lung cancer regulated an enzyme used in therapies against diabetes, ... Phenformin decreases size of lung tumors and increases survival in mice. *Download PDF Copy ... decreased the size of lung tumors in mice and increased the animals survival. The findings may give hope to the nearly 30 ... Lung Cancer, Lungs, Metabolism, Metformin, Mitochondria, Neuroscience, Non-Small Cell Lung Cancer, Personalized Medicine, Polio ...
VHIO scientists eradicate lung tumors in a pre-clinical mouse model The study, led by the Vall dHebron Institute of Oncology, ... regularly checking tumour progress in each mouse. All mice became tumour free after the first inhibition period, but 63% of ... VHIO scientists eradicate lung tumors in a pre-clinical mouse model. Vall dHebron Institute of Oncology ... has managed to eliminate mouse lung tumors by inhibiting Myc, a protein that plays a key role in the development of many ...
Mouse Mammary Tumor Metastases in Lung: An Electron Microscopic Study Message Subject (Your Name) has forwarded a page to you ... Mouse Mammary Tumor Metastases in Lung: An Electron Microscopic Study. Robert E. Brooks ... Metastatic mammary tumor nodules in lung were usually separated from lung tissue by a thickened basement membrane and loose ... Metastatic mammary tumor cells grew in multiple layers within lung. The stroma of the outermost layers consisted, at least in ...
Chimeric mouse tumor models reveal differences in pathway activation between ERBB family- and KRAS-dependent lung ... To recapitulate the stochastic nature of human cancer development, we have devised a strategy for generating mouse tumor models ... Tumors in the chimeric animals develop from engineered cells in the context of normal tissue. Adenocarcinomas arising in an ... Treatment of EGFR(L858R) and KRAS(G12V) chimeric models with an EGFR inhibitor resulted in near complete tumor regression and ...
In mice, inorganic arsenic in the drinking water in the parts per million range via the dam during in utero life or with whole- ... Thus, in CD1 mice whole-life arsenic exposure induced lung tumors at human-relevant doses (i.e., 50 and 500 ppb). ... Waalkes MP, Ward JM, Diwan BA (2004) Induction of tumors of the liver, lung, ovary and adrenal in adult mice after brief ... Lung tumors in mice induced by "whole-life" inorganic arsenic exposure at human-relevant doses. ...
... and ultra-deep barcode sequencing to interrogate pairwise combinations of tumor suppressor alterations. ... Researchers Map Tumor Suppressive Landscape of Lung Cancer in Mice Using CRISPR, Barcode Seq. Apr 03, 2018 ... Home » Researchers Map Tumor Suppressive Landscape of Lung Cancer in Mice Using CRISPR, Barcode Seq ... to interrogate pairwise combinations of mutations in tumor suppressor genes in autochthonous mouse models of human lung ...
Immune-cell therapy relies on modifying a patients own T-cells to attack a specific tumor. The problem is delivering enough T- ... Sixteen days after mice with lung and bone marrow tumors were subjected to the treatment their tumors disappeared entirely. ... Highly Targeted T-cell Therapy Destroys Lung and Bone Marrow Tumors in Mice. August 17th, 2010 Medgadget Editors News ... Less than 5 percent reach the tumor," says Irvine, who is also a Howard Hughes Medical Institute Investigator.. With a new way ...
Abstract 2869: Chemopreventive efficacy and mechanism of licofelone in mouse lung tumor model. Jin Lee ... Abstract 2869: Chemopreventive efficacy and mechanism of licofelone in mouse lung tumor model ... Abstract 2869: Chemopreventive efficacy and mechanism of licofelone in mouse lung tumor model ... Abstract 2869: Chemopreventive efficacy and mechanism of licofelone in mouse lung tumor model ...
MicroRNA-31 functions as an oncogenic microRNA in mouse and human lung cancer cells by repressing specific tumor suppressors. ... MicroRNA-31 functions as an oncogenic microRNA in mouse and human lung cancer cells by repressing specific tumor suppressors. ... Together, these findings revealed that miR-31 acts as an oncogenic miRNA (oncomir) in lung cancer by targeting specific tumor ... Notably, miR-31 and these target mRNAs were inversely expressed in mouse and human lung cancers, underscoring their biologic ...
In this study, the LMW serum proteome was compared between xenografted tumor-bearing mice and control mice by differential ... analysis of the low molecular weight serum proteome using 18O stable isotope labeling in a lung tumor xenograft mouse model. ... Mice are one of the most extensively used animal models for studying human disease because they represent a highly controllable ... Senger, D. R.; Galli, S. J.; Dvorak, A. M.; Perruzzi, C. A.; Harvey, V. S.; Dvorak, H. F. Tumor Cells Secrete A Vascular ...
Chemoprevention: mouse colon and lung tumor bioassay and modulation of DNA methylation as a biomarker. Exp Lung Res 2005; 31: ... Prevention of mouse lung tumors by budesonide and its modulation of biomarkers. Carcinogenesis 2002; 23: 1185-92.. *CrossRef, ... Prevention of mouse lung tumors by targretin. Int J Cancer 2006; 118: 2359-62.. Direct Link: ... Modulation by budesonide of DNA methylation and mRNA expression in mouse lung tumors. Int J Cancer 2007; 120: 1150-3.. Direct ...
We have designed BRaf(CA) mice to express normal BRaf prior to Cre-mediated recombination after which BRaf(VE) is expressed at ... A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumors Genes Dev. 2007 Feb 15; ... BRaf(CA) mice infected with an Adenovirus expressing Cre recombinase developed benign lung tumors that only rarely progressed ... Moreover, BRaf(VE)-induced lung tumors were prevented by pharmacological inhibition of MEK1/2. BRaf(VE) expression initially ...
... resulted in the formation of multiple skin tumors but failed to produce lung tumors. The whole-body exposure of C57BL/6 mice to ... Pilot studies evaluating the lung tumor yield in cigarette smoke-exposed mice. *Authors: *Francesco DAgostini ... both lung tumor incidence and multiplicity were significantly increased as compared to sham-exposed mice (77.8% vs. 22.2%, and ... failed to enhance the lung tumor yield. The whole-body exposure of SKH-1 hairless mice to ECS for 6 months, followed by ...
Fluorescence immunohistochemistry (IHC) of lung adenomas from NNK-treated mice and tumors from lung cancer patients that were ... Here we used human and mouse lung cancer samples and cell lines to determine a mechanism whereby NNK induced DNMT1 expression ... carcinogen NNK induces DNA methyltransferase 1 accumulation and tumor suppressor gene hypermethylation in mice and lung cancer ... carcinogen NNK induces DNA methyltransferase 1 accumulation and tumor suppressor gene hypermethylation in mice and lung cancer ...
Treating intestine with good cholesterol compound inhibits lung tumor growth in mice. UCLA RESEARCH ALERT. Alice G. Walton , ... The cancerous cells migrate to the lungs, where they grow into tumors. One group of mice was given Tg6F orally, starting the ... After four weeks of treatment, the number of tumor nodules was significantly lower in the lungs of Tg6F-fed mice - on average, ... The team used a mouse model of lung cancer, injecting cancer cells into the tail veins of mice. ...
Casc1 knockout mouse tumor bioassays showed that Casc1-deficient mice were susceptible to chemical induction of lung tumors. We ... Candidate lung tumor susceptibility genes identified through whole-genome association analyses in inbred mice.. Liu P1, Wang Y ... We performed a whole-genome association analysis of lung tumor susceptibility using dense SNP maps ( approximately 1 SNP per 20 ... We found that the Lasc1 Glu102 allele preferentially promotes lung tumor cell growth. Our findings demonstrate the prospects ...
5) growth of lung cancer cells in vitro and inhibited tumor growth in nude mouse lung cancer models given either i.p. or p.o. ( ... FTS-treated mice (p.o.; n = 8), gemcitabine-treated mice (n = 7), and gemcitabine plus FTS-treated mice (n = 8). Tumor weights ... Salirasib (FTS) Inhibits Tumor Growth in a Lung Cancer Cell Nude Mouse Model. We next examined the in vivo effect of salirasib ... Suppression of lung cancer tumor growth in a nude mouse model by the Ras inhibitor salirasib (farnesylthiosalicylic acid). Adi ...
Peloruside A Inhibits Growth of Human Lung and Breast Tumor Xenografts in an Athymic nu/nu Mouse Model. Colin J. Meyer, Melissa ... Peloruside A Inhibits Growth of Human Lung and Breast Tumor Xenografts in an Athymic nu/nu Mouse Model ... Peloruside A Inhibits Growth of Human Lung and Breast Tumor Xenografts in an Athymic nu/nu Mouse Model ... Peloruside A Inhibits Growth of Human Lung and Breast Tumor Xenografts in an Athymic nu/nu Mouse Model ...
Hyperinsulinemia in a mouse model promotes breast cancer metastasis to the lung. Therapies to reduce insulin levels in ... Hyperinsulinemia enhances c-Myc-mediated mammary tumor development and advances metastatic progression to the lung in a mouse ... Conclusions: Hyperinsulinemia in a mouse model promotes breast cancer metastasis to the lung. Therapies to reduce insulin ... hyperinsulinemic mice demonstrated a significantly higher number of lung metastases after a four-week period (hyperinsulinemic ...
Data for tumor model Lewis Lung Carcinoma (intramuscular) in B6D2F1 (BDF1) mice. ...
Matrix Metalloproteinase 1 promotes tumor formation and lung metastasis in an intratibial injection osteosarcoma mouse model ... Matrix Metalloproteinase 1 promotes tumor formation and lung metastasis in an intratibial injection osteosarcoma mouse model. ... The findings of the present study reveal an important role of MMP-1 in OS primary tumor and metastasis formation to the lung, ... The findings of the present study reveal an important role of MMP-1 in OS primary tumor and metastasis formation to the lung, ...
Tumor weight per mouse (g) is presented as mean and SE (bars) of 10 tumors from individual mouse in each group at the end of ... Effect of silibinin, doxorubicin, and their combination on in vivo lung tumor growth in athymic nude mice. Human lung carcinoma ... Oral Silibinin Inhibits Lung Tumor Growth in Athymic Nude Mice and Forms a Novel Chemocombination with Doxorubicin Targeting ... Oral Silibinin Inhibits Lung Tumor Growth in Athymic Nude Mice and Forms a Novel Chemocombination with Doxorubicin Targeting ...
COPS3 shRNA knockdown inhibits tumor growth in nude mice. A. Representative images of xenograft tumors in nude mice treated ... In a xenograft tumor model in nude mice, shRNA-knockdown of COPS3 significantly reduced tumor growth. In lung adenocarcinoma ... Knockdown of COPS3 Inhibits Lung Cancer Tumor Growth in Nude Mice by Blocking Cell Cycle Progression Jianan Pang1, Xu Yan2, He ... Tumorigenesis in nude mice. The role of COPS3 in lung cancer tumorigenesis was examined in BALB/c nude mice (8-12 weeks old, 22 ...
... whereas miR-1 and miR-143 were downregulated in lung tumors relative to normal lungs. In mice treated with VC and given I3C in ... Alteration of microRNA expression in vinyl carbamate-induced mouse lung tumors and modulation by the chemopreventive agent ... Microarray studies revealed alterations in the expression of a number of miRNAs in lung tumors relative to that of normal lungs ... induced deregulation of miRNA levels in lung tissues of female A/J mice. Lung tissues were obtained from a previous ...
In a xenograft tumor model in nude mice, shRNA-knockdown of COPS3 significantly reduced tumor growth. In lung adenocarcinoma ... Knockdown of COPS3 Inhibits Lung Cancer Tumor Growth in Nude Mice by Blocking Cell Cycle Progression Jianan Pang1, Xu Yan2, He ... Knockdown of COPS3 Inhibits Lung Cancer Tumor Growth in Nude Mice by Blocking Cell Cycle Progression. J Cancer 2017; 8(7):1129- ... "Region of Increased Tumor Expression") genes in lung cancer tissues. To elucidate the specific role of COPS3 in lung cancer, we ...
... study was to evaluate the impact of pemetrexed and the tumor graft on the gut microbiota composition in immunodeficient mice. ... This pilot study shows that the association of a lung tumor graft with pemetrexed causes an alteration in the microbiota ... The tumor graft induced some variations in the microbiota composition. Pemetrexed further increased the relative abundance of ... Pemetrexed, a chemotherapeutic agent used in non-small cell lung cancer, can induce significant side effects in patients. ...
Lung cancer signatures in plasma based on proteome profiling of mouse tumor models.. ... Lung cancer signatures in plasma based on proteome profiling of mouse tumor models. ... Lung cancer signatures in plasma based on proteome profiling of mouse tumor models. ... A protein signature for Titf1/Nkx2-1, a known lineage-survival oncogene in lung cancer, was found in plasmas of mouse models of ...
Lung tumors were induced in female strain A mice by vinyl carbamate (16 mg/kg) administered once weekly for 2 consecutive weeks ... Lung tumors were induced in female strain A mice by vinyl carbamate (16 mg/kg) administered once weekly for 2 consecutive weeks ... In this study, the ability of budesonide to prevent lung tumors in mice was characterized further and its effects on biomarkers ... In this study, the ability of budesonide to prevent lung tumors in mice was characterized further and its effects on biomarkers ...
  • The team's earlier work had found that small peptide "mimetics," or mimics, of an HDL protein reduced tumor growth in mice, but it wasn't totally clear which immune and genetic mechanisms were responsible for the connection. (
  • In a xenograft tumor model in nude mice, shRNA-knockdown of COPS3 significantly reduced tumor growth. (
  • CD69−/− mice challenged with MHC class I − tumors (RMA-S and RM-1) showed greatly reduced tumor growth and prolonged survival compared with wild-type (WT) mice. (
  • The ultrastructure of mammary carcinoma metastatic to the lungs of old, female (C57L × A/He)F 1 hybrid and C3H/Crgl mice is described and illustrated. (
  • The four typical subgroups of these lung cancers are squamous cell carcinoma, large cell carcinoma, small-cell carcinoma, and adenocarcinoma ( 5 ). (
  • Non-small cell lung carcinoma (NSCLC) represents 85% of cases of lung cancer ( 6 ). (
  • Using a hyperinsulinemic mouse model (MKR+/+) and the metastatic, c-Myc-transformed mammary carcinoma cell line Mvt1, we investigated how high systemic insulin levels would affect the progression of orthotopically inoculated primary mammary tumors to lung metastases. (
  • Human lung carcinoma A549 cells (3 × 10 6 ) were mixed with Matrigel and subcutaneously injected in the right flank of athymic nude mice (BALB/c nu/nu ). (
  • We found that COPS3 was overexpressed in most of the lung cancer samples examined, particularly in small cell carcinoma and squamous cell carcinoma. (
  • The antimetastatic effect of Lactobacillus casei YIT9018 (LC 9018) against Lewis lung carcinoma (3LL) in C57BL/6 mice was determined. (
  • The effect of exposure to hypoxia on metastasis of Lewis lung carcinoma in mice was also investigated. (
  • Our previous study has proved that anti-DKK2 antibody 5F8 suppressed the growth of colorectal carcinoma with APC mutations, illustrating a new target agent of APC-mutated tumors. (
  • In 2004, APC mutations have been reported in lung NSCLC and small-cell lung carcinoma 25 . (
  • In our recent study, we uncovered a function of DKK2 in promoting tumor progression by suppressing cytotoxic immune cell activation in colorectal carcinoma with APC mutations 29 . (
  • We also restored gene expression in the Parkin -deficient lung carcinoma cell line H460 by use of a recombinant lentivirus containing the wild-type Parkin cDNA. (
  • Effect of Heparin and Its Derivatives On the Progression of Tumor Growth in Mouse Lewis Lung Carcinoma Model. (
  • This study was designed to investigate whether heparin and its derivatives are able to inhibit tumor growth in a Lewis Lung carcinoma model. (
  • Progressive growth of Lewis lung carcinoma in C57Bl/6 mice resulted in a marked leukocytosis, increased serum level of granulocyte/macrophage-colony-stimulating factor, and splenomegaly. (
  • Gene expression profiles of primary tumors with radiotherapy and lung metastases in mouse squamous cell carcinoma model. (
  • To examine whether the local carbon ion radiotherapy affects the characteristics of the metastatic tumors, the expression profiles of the primary tumors and the lung metastases were studied in a mouse squamous cell carcinoma model by applying local radiotherapy with no irradiation (negative control), gamma-ray irradiation (reference beam), and carbon-ion irradiation. (
  • Keywords: mouse, squamous cell carcinoma, primary tumor, lung metastases, radiotherapy, carbon ion, gamma ray Overall design: A highly metastatic mouse squamous cell carcinoma NR-S1 was implanted into the hind leg of synergetic C3H/HeNrs mice and irradiated with 5 Gy of carbon ion beam. (
  • Implantation of a fast-growing tumor to mice (Lewis lung carcinoma) resulted in a clear cachectic state characterized by a profound muscle wasting. (
  • Trehalose Liposomes Suppress the Growth of Tumors on Human Lung Carcinoma-bearing Mice by Induction of Apoptosis In Vivo. (
  • The metabolic products formed and incorporated into the nucleic acids (RNA and DNA) of mice bearing Lewis lung carcinoma (LLC) following optimal doses of 5-fluorouracil (FUra), 5-fluoro-2'-deoxyuridine (FdUrd), and 5-fluoro-2'-deoxycytidine (FdCyd) coadministered with tetrahydrouridine (H 4 Urd), a potent inhibitor of cytidine deaminase, were examined. (
  • They found that early phenformin treatment causes increased survival and slower tumor progression in tumors lacking LKB1, but had no significant benefit for tumors with alterations in other lung cancer genes. (
  • In conclusion, this study demonstrated that Licofelone administered by aspiration showed chemopreventive efficacy against mouse lung adenoma with good correlation to early and late biomarkers of lung cancer progression. (
  • Consistent with Ink4a/Arf and TP53 tumor suppressor function, BRaf(VE) expression combined with mutation of either locus led to cancer progression. (
  • Administering 2.4 mg/kg budesonide at weeks 4-20 or 20-35 and killing the mice at week 35 did not significantly decrease the yield of tumors, although both treatment regimens did decrease the size of the tumors and the progression of adenomas to carcinomas. (
  • Thus, budesonide delayed the appearance of lung tumors and decreased their growth and progression to carcinomas. (
  • During this talk I will discuss our experimental approaches and the involvement of neutrophils in lung adenocarcinoma progression. (
  • Hypoxia has been identified as a major negative factor for tumor progression in clinical observations and in animal studies. (
  • However, the precise role of hypoxia in tumor progression has not been fully explained. (
  • This study demonstrated that long-term exposure to hypoxia repressed tumor progression of the lung cancer from A549 cells and that decreased expression of Na + -K + ATPase was involved in hypoxic inhibition of tumor progression. (
  • The results from this study provide new insights into the role of hypoxia in tumor progression and therapeutic strategies for cancer treatment. (
  • In addition to observations from clinical data, animal experiments have investigated the relationship between tumor hypoxia and cancer progression. (
  • Similarly, overexpression of TLR4 in mice has led to the production of anti-dsDNA and the immune complex-mediated glomerulonephritis, suggesting that TLR4 signaling plays critical roles in lupus progression [ 7 ]. (
  • Preclinical evidence suggests that heparins have an effect on tumor progression independent of their anticoagulant activity. (
  • Significant group differences could be detected between transgenic and normal animals for time points 8 to 13 months ( p = 0.043), when marked tumour progression occurred. (
  • Histopathology of this animal model has been obtained at different time-points to show the time course of the tumour progression. (
  • Despite the ability to generate immune reactivity against tumor Ags, the immune surveillance program can be overpowered by tumors with eventual tumor progression ( 2 , 3 , 4 , 5 ). (
  • The Feldser lab uses genetically engineered mouse models to study tumor progression and metastasis of common forms of human cancer. (
  • We couple cellular, genomic and biochemical analyses to our powerful in vivo tools to discern the mechanics of tumor progression and metastasis with the goal of identifying new therapeutic strategies to eradicate malignant cells. (
  • thus far they have been uninformative on the precise mechanistic role of FGFR3 mutations in tumor formation and progression. (
  • Three xenograft studies in athymic nu / nu mice were performed to assess the efficacy of peloruside compared with standard anticancer agents such as paclitaxel, docetaxel, and doxorubicin. (
  • In a second xenograft study using A549 lung cancer cells and varied schedules of dosing, activity of peloruside was again superior compared with the taxanes with inhibitions ranging from 51% to 74%, compared with 44% and 50% for the two taxanes. (
  • A third xenograft study in a P-glycoprotein-overexpressing NCI/ADR-RES breast tumor model showed that peloruside was better tolerated than either doxorubicin or paclitaxel. (
  • Here, for the first time we evaluated and observed antitumor effects of silibinin alone and in doxorubicin combination against lung tumor xenograft growth. (
  • In this extended study, we focused on the role of COPS3 in an in vivo tumor xenograft model. (
  • Furthermore, it offers the opportunity to study carcinogenesis in a more realistic setting as compared to models of implanted (xenograft) tumours into immunodeficient mice. (
  • 45% of A549 and H446 cells formed large clones that are able to generate subclones and subsequently give rise to xenograft tumors in the BALB/C-nude mouse. (
  • The goal of this study was to determine whether breast cancer (BC) patient-derived xenograft (PDX) mice could provide a constant and renewable source of CTCs and BM-DTCs, thereby representing a unique system for the study of metastatic processes. (
  • Xenograft and orthotopic models with A549 cells were used to evaluate the anti-tumor effect of shikonin in vivo. (
  • NEW YORK (GenomeWeb) - Researchers at Stanford University and the Massachusetts Institute of Technology used a combination of tumor barcoding, CRISPR-Cas9-mediated genome editing, and ultra-deep barcode sequencing to interrogate pairwise combinations of mutations in tumor suppressor genes in autochthonous mouse models of human lung adenocarcinoma in order to determine the functional impact of these alterations. (
  • BRaf(CA) mice infected with an Adenovirus expressing Cre recombinase developed benign lung tumors that only rarely progressed to adenocarcinoma. (
  • In lung adenocarcinoma A549 cells, shRNA-knockdown of COPS3 induced cell cycle arrest at G0/G1 phase by upregulating the cell cycle regulator protein P21 and downregulating cyclin B1 and CDK4. (
  • Non-small cell lung cancer accounts for approximately 85% of all lung cancer cases, and adenocarcinoma is the most common subtype of lung cancer. (
  • In a previous cell study, we have demonstrated that COPS3 is highly expressed in lung adenocarcinoma cell lines [ 11 ]. (
  • A protein signature for Titf1/Nkx2-1, a known lineage-survival oncogene in lung cancer, was found in plasmas of mouse models of lung adenocarcinoma. (
  • Lung cancer is the leading cause of cancer-related deaths worldwide in women and men, with adenocarcinoma representing the main histological subtype. (
  • Here, I will present our recent data obtained upon exhaustive extraction and analysis of tumor-associated immune cells from a mouse model of lung adenocarcinoma. (
  • Comprehensive molecular profiling of lung adenocarcinoma. (
  • Interestingly, APC mutations in lung cancer co-occurred with KRAS mutations in NSCLC, including adenocarcinoma and SCCs 26 . (
  • In addition, homozygous deletions of exon 2 creating deleterious truncations of the Parkin transcript were observed in the lung adenocarcinoma cell lines Calu-3 and H-1573, suggesting that the loss of this locus and the resulting changes in its expression are involved in the development of these tumors. (
  • Two-hit inactivation of CDKN2A and CDKN2B occurs frequently in patients with mutant KRAS lung adenocarcinoma. (
  • These findings indicate that mutant Kras;Cdkn2ab null mice provide a platform for accurately modeling aggressive lung adenocarcinoma and testing therapeutic modalities. (
  • Lung adenocarcinoma, a leading source of cancer-related mortality worldwide ( 1 ), harbors recurrent genomic abnormalities that provide a framework for the selection of targeted therapeutic agents ( 2-4 ). (
  • SPC-c-Raf-1-BxB transgenic mice develop genetically induced disseminated lung adenocarcinoma allowing examination of carcinogenesis and evaluation of novel treatment strategies. (
  • The presented region-growing segmentation algorithm allows in-vivo quantification of multifocal lung adenocarcinoma in SPC-raf transgenic mice. (
  • This animal model allows probing for mechanisms of carcinogenesis based on a genetic cascade that also plays a crucial role in the development of adenocarcinoma of the lungs in humans. (
  • In this study, the effects of Cornus Mas L (C. mas L) in different dosages on the biochemical values of mice organs were investigated in the Ehrlich Ascites tumor model, which originated from mice breast adenocarcinoma and developed in Balb/C mice. (
  • In this study, we investigated the recruitment of exogenous EPCs in human lung adenocarcinoma model of nude mice . (
  • EPCs labeled with green fluorescence protein (GFP) were transplanted into nude mice bearing human lung adenocarcinoma . (
  • Metastatic mammary tumor nodules in lung were usually separated from lung tissue by a thickened basement membrane and loose connective tissue. (
  • A narrow, compact zone of lung tissue surrounded the metastatic nodules. (
  • Metastatic mammary tumor cells grew in multiple layers within lung. (
  • Similarly, when Mvt1 cells were injected intravenously, hyperinsulinemic mice demonstrated a significantly higher metastatic burden in the lung than controls after a three-week period (hyperinsulinemic, 6.0 ± 1.63 vs. control, 1.5 ± 0.68). (
  • Furthermore, insulin-lowering therapy using the beta-adrenergic receptor agonist CL-316243 reduced metastatic burden in hyperinsulinemic mice to control levels. (
  • The effects of lovastatin, a potent inhibitor of hydroxymethylglutaryl-coenzyme A reductase, were studied in a mouse model of metastatic mammary cancer carrying a p53 mutation. (
  • The tumor cells of the primary and metastatic tumors were collected by laser microdissection, and oligonucleotide microarray analysis of the irradiated primary tumors and the metastatic tumors were all performed in comparison to the non-irradiated primary tumor by two-color methods. (
  • Importantly, complete loss of CDKN2AB strikingly accelerated mutant Kras -driven lung tumorigenesis, leading to loss of differentiation, increased metastatic disease, and decreased overall survival. (
  • Thus, the loss of CDKN2AB is of biologic significance in mutant KRAS lung tumorigenesis by fostering cellular proliferation, cancer cell differentiation, and metastatic behavior. (
  • Small cell lung cancer (SCLC) is an aggressive and highly metastatic lung cancer subtype. (
  • Small cell lung cancer (SCLC) is an aggressive, highly metastatic lung cancer subtype, and represents 13% of all newly diagnosed cases of lung cancer ( 1 ). (
  • Is the Subject Area "Metastatic tumors" applicable to this article? (
  • Two separate genetic signatures associated with the presence of CTC clusters and with lung metastatic potential were computed by using the expression arrays of primary tumors from different PDX lines and subsequently overlapped to identify common genes. (
  • Overlapping of the two genetic signatures of the primary PDX tumors associated with the presence of CTC clusters and with lung metastatic potential identified four genes ( HLA-DP1A , GJA1 , PEG3 , and XIST ). (
  • Light emitted as part of traditional cancer -imaging techniques, to locate metastatic tumors, also can trigger light-sensitive drugs, according to the new study. (
  • The researchers showed that the technique worked effectively in mice with multiple myeloma, a cancer of white blood cells , and aggressive metastatic breast cancer . (
  • This specificity in treatment fits with an emerging approach in cancer treatment nationwide, known as personalized medicine, in which the therapies for each patient are selected based on the genes altered in their tumors. (
  • These targets included the tumor-suppressive genes large tumor suppressor 2 (LATS2) and PP2A regulatory subunit B alpha isoform (PPP2R2A), and expression of each was augmented by miR-31 knockdown. (
  • NNK also induced βTrCP translocation to the cytoplasm via the heterogeneous nuclear ribonucleoprotein U (hnRNP-U) shuttling protein, resulting in DNMT1 nuclear accumulation and hypermethylation of the promoters of tumor suppressor genes. (
  • We believe that the NNK-induced DNMT1 accumulation and subsequent hypermethylation of the promoter of tumor suppressor genes may lead to tumorigenesis and poor prognosis and provide an important link between tobacco smoking and lung cancer. (
  • Candidate lung tumor susceptibility genes identified through whole-genome association analyses in inbred mice. (
  • It has been established that lung cancer arises as a consequence of the accumulation of multiple genetic changes involving critical genes that control cell motility, proliferation, differentiation, and apoptosis ( 2 ). (
  • COPS3 encodes the third subunit of the COP9 signalosome and its aberrant expression is associated with many RITE ("Region of Increased Tumor Expression") genes in lung cancer tissues. (
  • Therefore, miRNAs and their target genes are promising biomarkers for the diagnosis of lung cancer and efficacy of chemopreventive/chemotherapeutic agents. (
  • Lung cancer commonly displays a number of recurrent genetic abnormalities, and about 30% of lung adenocarcinomas carry activating mutations in the Kras gene, often concomitantly with inactivation of tumor suppressor genes p16 INK4A and p14 ARF of the CDKN2AB locus. (
  • Thus, the relevance of overexpressed protooncogenes or disabled tumour suppressor genes can be studied. (
  • Tumors initiate as lesions within the appropriate tissue microenvironment from single cells due to induced activation of latent oncogenes and/or deletion of key tumor suppressor genes. (
  • The major emphasis of our laboratory is to uncover the pathways that are disabled by mutational inactivation of tumor-suppressor genes as well as those pathways stimulated by aberrant oncogene activation. (
  • When Mvt1-mediated mammary tumors were allowed to develop and metastasize for approximately two weeks and were then surgically removed, hyperinsulinemic mice demonstrated a significantly higher number of lung metastases after a four-week period (hyperinsulinemic, 25.1 ± 4.6 vs. control, 7.4 ± 0.42). (
  • Furthermore, and most importantly, individual MMP-1 overexpression in HOS cells enabled the formation of osteolytic primary tumors and lung metastasis while the HOS control cells did not develop any tumors or metastases after intratibial injection. (
  • Depletion of CD8 + T cells as well as targeting T-bet abrogated the protective effects of EBI-3 deficiency on lung melanoma metastases. (
  • Moreover, the CRF2R agonist significantly reduced both the number of metastases and their mass (at day 19 after tumor inoculation: 66% and 61%, respectively). (
  • In vivo, Mono-7D6-Fab induced T cell antigen-dependent therapeutic responses against melanoma lung metastases, an effect that synergized with other anti-melanoma immunotherapies to significantly improve outcome and survival. (
  • The rate of lung metastases (LM) was previously reported in these lines. (
  • This study suggests that CTCs and BM-DTCs detected in BC PDX-bearing mice may represent a valuable and unique preclinical model for investigating the role of these rare cells in tumor metastases. (
  • The expression of COPS3 protein was positively correlated with the level of Ki-67 cell proliferation index (p=0.001) and negatively related to the degree of tumor differentiation (p=0.012). (
  • Knockdown of COPS3 significantly inhibits tumor cell proliferation in this in vitro model. (
  • Although we did not observe any in vitro changes in cell proliferation or cell cycle, ectopic Parkin expression had the ability to reduce in vivo tumorigenicity in nude mice. (
  • The chemicals are activated to reactive intermediates, leading to local cytotoxicity or mitogenicity resulting in increased cell proliferation and tumors. (
  • Furthermore, administration of fluensulfone to mice led to an early increase in Clara cell proliferation. (
  • Here, we sought to comprehensively identify the miRNAs that are overexpressed in lung cancer by conducting miRNA microarray expression profiling on normal lung versus adjacent lung cancers from transgenic mice. (
  • We found that miR-136, miR-376a, and miR-31 were each prominently overexpressed in murine lung cancers. (
  • Notably, miR-31 and these target mRNAs were inversely expressed in mouse and human lung cancers, underscoring their biologic relevance. (
  • Aberrant Ras pathway functions contribute to the malignant phenotype of lung cancers. (
  • In preclinical animal studies, β-carotene had been effective against some chemically induced cancers, but not against tumors in the respiratory tract. (
  • We found significant upregulation of Dkk2 expression in APC -mutated lung cancers. (
  • The researchers say the versatile probiotic platform could be used to deliver multiple immunotherapies simultaneously, enabling the release of effective therapeutic combinations within the tumor for hard-to-treat cancers. (
  • This is the second time we've shown how to engineer an effective decoy protein and used it to inhibit tumor growth in animals," said Cochran, the Shriram Chair of the Department of Bioengineering at Stanford, whose group initially developed this strategy in earlier experiments aimed at ovarian and breast cancers . (
  • These observations suggest that chromosome 6q25-q27 harbors a tumor suppressor gene (TSG) involved in a wide variety of human cancers. (
  • These data add to the growing evidence supporting the use of liquid biopsies, particularly when tissue samples are nonexistent or hard to obtain, as is often the case with lung cancer and other cancers that have metastasized throughout the body. (
  • Moreover, p15INK4B loss occurs in the presence of biallelic inactivation of p16 INK4A and p14 ARF , suggesting that p15INK4B loss confers a selective advantage to mutant KRAS lung cancers that are p16 INK4A and p14 ARF deficient. (
  • Aberrant expression of nestin is linked to poor prognosis in different cancers, including non-small cell lung cancer. (
  • Sulindac sulfide, a COX inhibitor, inhibited the growth of non-small-cell lung cancers (NSCLC) both in soft agar and as xenografts in nude mice. (
  • Lung cancer screening refers to cancer screening strategies used to identify early lung cancers before they cause symptoms, at a point where they are more likely to be curable. (
  • RGS17 is overexpressed in lung and prostate cancers, induces cAMP production, CREB phosphorylation and CREB responsive gene expression[2]. (
  • The findings may give hope to the nearly 30 percent of patients with non-small cell lung cancer (NSCLC) whose tumors lack LKB1 (also called STK11). (
  • Based on their findings, the researchers say that phenformin would be most useful in treating early-stage LKB1-mutant NSCLC, as an adjuvant therapy following surgical removal of a tumor, or in combination with other therapeutics for advanced tumors. (
  • Lung cancer exhibits the following two predominant pathological types: non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). (
  • In this report, we describe the LOH analysis of the Parkin/FRA6E locus at 6q25-q27 and the status of the Parkin coding sequence and its expression in 20 matched normal and non-small cell lung cancer (NSCLC) samples in gene sequence screening. (
  • Tumor (NSCLC) and normal tissue were snap-frozen. (
  • In patients with advanced non-small cell lung cancer (NSCLC) treated at Penn's ACC, mutations detected from liquid biopsies (cell-free circulating tumor DNA (ctDNA) captured from blood) closely paralleled the mutations from tissue biopsies identified in next generation sequencing tests: EGRF, TP53, and ALK, to name a few. (
  • For these reasons, intense research efforts are under way to characterize the biologic and therapeutic significance of recurrent genomic abnormalities in non-small cell lung cancer (NSCLC). (
  • The purpose of this study was to evaluate the anti- tumor effect of 131Ⅰ-Tyr- octreotide in nude mice bearing human non-small cell lung cancer (NSCLC). (
  • The nude mice models bearing human NSCLC were studied and divided into four groups group A injected 131Ⅰ-Tyr- octreotide through tail vein , group B injected normal saline , group C injected 131Ⅰ-Tyroctreotide through stroma and group D injected 131Ⅰ through stroma. (
  • Conclusions 131Ⅰ-Tyr- octreotide was easily labeled by Ch-T. 131Ⅰ-Tyr- octreotide could induce tumor cell apoptosis and inhibit the tumor cell of NSCLC. (
  • The use of small-molecule tyrosine kinase inhibitors and immunotherapy have led to large survival benefits in patients with advanced non-small lung cancer (NSCLC) over the past 2 decades ( 2 ). (
  • This study was designed to clarify whether shikonin causes necroptosis in non-small cell lung cancer (NSCLC) cells and to investigate the mechanism of action. (
  • Furthermore, we tested whether shikonin can induce necroptosis and autophagy in non-small cell lung cancer (NSCLC) cells and whether the inhibition of autophagy can drive lung cancer cells to necroptosis. (
  • In the study, multiple lung tumours were induced in the mouse (up to 200 tumours in each individual) and Myc inhibition episodes were achieved by activating Omomyc expression for 4-weeks, followed by 4-week rest periods. (
  • All mice became tumour free after the first inhibition period, but 63% of cases then relapsed. (
  • Finally, only two remaining tumours were found after more than one year of treatment among the mice that received eight inhibition and rest cycles. (
  • Previous studies conducted by Dr Soucek had already shown that Myc inhibition could halt tumour processes, making it an interesting therapeutic target for new drug development. (
  • Moreover, BRaf(VE)-induced lung tumors were prevented by pharmacological inhibition of MEK1/2. (
  • Peloruside caused tumor growth inhibition (%TGI) of 84% and 95%, respectively, whereas standard treatments with paclitaxel (8 mg/kg, QD×5) and docetaxel (6.3 mg/kg, Q2D×3) were much less effective (%TGI of 50% and 18%, respectively). (
  • These findings suggest that silibinin inhibits in vivo lung tumor growth and reduces systemic toxicity of doxorubicin with an enhanced therapeutic efficacy most likely via an inhibition of doxorubicin-induced chemoresistance involving NFκB signaling. (
  • We showed that tumors arising in hypoxic animals have increased sensitivity to VEGFR-2/EGFR inhibition, as chemoprevention with vandetanib showed markedly increased activity in hypoxic mice. (
  • Furthermore, the differential sensitivity of tumors arising in hypoxia to VEGFR-2/EGFR inhibition suggests that the altered signaling present in tumors arising in hypoxic lung might be therapeutically exploited in patients with underlying COPD. (
  • We propose that PPARγ serves as a target for NSAIDs that accounts for COX-independent inhibition of lung cancer cell growth. (
  • We conclude that peloruside is highly effective in preventing the growth of lung and P-glycoprotein-overexpressing breast tumors in vivo and that further therapeutic development is warranted. (
  • In this study we evaluate a microCT imaging algorithm to assess in-vivo tumour load and quantification of tumour growth in a transgenic disease model of lung adenocarcinomas. (
  • The imaging algorithm allows in vivo quantification of lung tumor load and tumor growth in transgenic mice with an acceptable intra- and interobserver variability. (
  • In the present study, the biological relevance of MMP-1 in osteosarcoma (OS) tumor growth and metastasis was investigated in vitro and in vivo. (
  • Effect of silibinin, doxorubicin, and their combination on in vivo lung tumor growth in athymic nude mice. (
  • In lipoprotein receptor-related protein 6-null homozygous mice, which lack a Wnt coreceptor, BAT-gal staining is absent in mutant tissues, indicating that BAT-gal mice are bona fide in vivo indicators of Wnt/β-catenin signaling. (
  • We investigated the in vivo role of CD69 by analyzing the susceptibility of CD69−/− mice to tumors. (
  • Moreover, the in vivo blockade of TGF-β in WT mice resulted in enhanced anti-tumor response. (
  • In addition, we show the in vivo reduction of tumorigenicity in the lung-tumor-derived cell line H460 lentivirally transduced with recombinant Parkin . (
  • This study uses microarray analysis to examine the fate of multiple C-ion-irradiated tumors in vivo to gain a comprehensive overview of the changes in gene expression induced by C-ion irradiation. (
  • Four murine tumors were irradiated in vivo with C-ions at a single dose, and gamma-rays were used as a reference beam. (
  • Docetaxel (5-20 mg/kg) treatment alone had only a minimal effect on growth of established 3LL tumors in vivo, although docetaxel was cytotoxic to 3LL cells in vitro. (
  • To determine the significance of CDKN2AB loss in vivo , genetically engineered lung cancer mouse models that express mutant Kras in the respiratory epithelium were utilized. (
  • Several studies established that p16 INK4A and p14 ARF are bona fide tumor suppressors in vivo , including in mutant KRAS lung adenocarcinomas ( 6 , 9 , 15-17 ). (
  • We here report on longitudinal in-vivo micro-CT measurements of lung tumour in a transgenic mouse model of lung cancer. (
  • Tumor incidence and multiplicity in the lung were measured following 16-week aspiration of Licofelone and compared with B[a] P only group. (
  • After 6 months of exposure, 6 h a day, followed by 4 months of recovery in filtered air, both lung tumor incidence and multiplicity were significantly increased as compared to sham-exposed mice (77.8% vs. 22.2%, and 1.11±0.26 vs. 0.22±0.15, means ± SE). (
  • The notion that Ras signaling contributes to the maintenance of the transformed phenotype of lung cancer cells ( 7 - 9 ) is supported by the high incidence of growth factor receptor (e.g., epidermal growth factor receptor) expression and, as mentioned above, the significant incidence of Ras mutations and up-regulated cyclin D1 in these tumor cells. (
  • After 9 months, lung tumor multiplicities and incidence were determined. (
  • Although much effort has been made and the overall cancer incidence rate has decreased in the most recent time period, a total of more than 1.5 million new cancer cases and more than half million deaths from cancer are projected to have occurred in the United States in 2010, of which lung cancer is the leading cause of cancer death in both men and women [ 5 ]. (
  • At 48 weeks, carcinogenic metal-containing GMA-SS fume caused the greatest increase in tumor multiplicity and incidence, but this was not different from sham. (
  • By 78 weeks, tumor incidence in the GMA-SS group versus sham approached significance (p = 0.057). (
  • Animals were killed 9 months after localized irradiation, their lungs were cleared, and the tumors were counted to determine both percentage incidence and tumors/mouse. (
  • Fluensulfone has shown an increased incidence of lung adenomas in mice, but not in rats, at high doses. (
  • Dogs have an overall reported incidence of mammary tumors of 3.4 percent. (
  • Tumors in the chimeric animals develop from engineered cells in the context of normal tissue. (
  • Through constructing a transcriptome map of human lung tissue, Zhou and colleagues have discovered the amplification of 17p11 in lung cancer [ 11 ], suggesting that COPS3 might contribute to the development of lung cancer. (
  • To study these crucial aspects of tumor growth, we are using genetically-engineered mouse models, complemented by in vitro and bioinformatics approaches, as well as human tumor tissue analyses. (
  • lung tissue. (
  • Among the 50 patients, 41 mutations were detected by both methods, while 24 therapeutically targetable driver EGFR mutations (a known driver of lung disease) were detected in tissue samples and 19 in ctDNA samples. (
  • At 2 weeks after the irradiation, the lung tissue was sampled. (
  • Here, male and female B6C3F1 mice were given single or fractionated whole-body exposure(s) to a monoenergetic carbon ion radiotherapy beam at the Heavy Ion Medical Accelerator in Chiba, Japan, matching the radiation quality delivered to the normal tissue ahead of the tumour volume. (
  • Tissue hypoxia within tumors has been shown to influence prognosis, by increasing angiogenesis and resistance to apoptosis, but we are not aware of studies of the effects of alveolar hypoxia on the development of lung cancer. (
  • Injection of microscopic particles of a plastic-like material protects mice from cardiac tissue damage following heart attack. (
  • 990-fold higher in tumor compared to normal tissue following FdCyd plus H 4 Urd administration. (
  • DNA-level antimetabolites (FdCyd, 5-fluorodeoxycytidylate, FdUrd, and FdUMP) were from 2- to 6-fold higher in tumor compared to normal tissue. (
  • In tumor tissue, optimal doses of FUra or FdUrd resulted in lower (a) FdUMP levels (5- to 2-fold), (b) RNA-level antimetabolites (6- to 3-fold), and (c) DNA-level antimetabolites (10- to 4-fold) compared to an optimal dosage of FdCyd plus H 4 Urd. (
  • H 4 Urd treatment of 25 mg/kg did not affect the elevated levels of deoxycytidine kinase or deoxycytidylate deaminase in LLC tumor tissue or the low levels found in normal tissue. (
  • The radioactivity ratio of tumor to normal tissue (T/NT) was calculated over region of interest (ROI). (
  • Real-time RT-PCR and in situ hybridization (ISH) assays confirmed these miRNA expression profiles in paired normal-malignant lung tissues from mice and humans. (
  • The clinical relevance of miR-31 expression was further independently and comprehensively validated using an array containing normal and malignant human lung tissues. (
  • To elucidate the specific role of COPS3 in lung cancer, we examined its expression in lung cancer tissues by immunohistochemical staining. (
  • In the present study, we examined if the chemopreventive agent indole-3-carbinol (I3C) reversed vinyl carbamate (VC)-induced deregulation of miRNA levels in lung tissues of female A/J mice. (
  • Lung tissues were obtained from a previous chemoprevention study, in which mice were treated with VC and given I3C in the diet for 15 weeks. (
  • In contrast to lung cancer, the growth of tumor from HCT116 human colon cancer cells (colon cancer tumor) was a) significantly enhanced in the same hypoxia conditions, accompanied by b) no significant change in expression of Na + -K + ATPase α1, c) increased HIF1α expression (no HIF2α was detected) and d) increased microvessel density in the tumor tissues. (
  • Domains of Wnt expression have been extensively investigated in the mouse, but the tissues receiving the signal remain largely unidentified. (
  • Tumor samples and corresponding noncancerous tissues were obtained from patients undergoing cancer surgery at the Hospital of University of Pennsylvania. (
  • The majority of tumors arise in soft tissues derived from the first branchial arch. (
  • 5400-fold higher levels of the potent thymidylate synthetase inhibitor, 5-fluoro-2'-deoxyuridylate (FdUMP), were formed in tumor than in any of the normal tissues analyzed. (
  • The formation of di- and triphosphate antimetabolite pools and the incorporation of antimetabolites into the RNA and DNA of normal and tumor tissues demonstrated trends similar to those mentioned above with nucleoside, mononucleotide, and free base pools. (
  • 93%. Although [ 3 H]FdCyd was utilized far more by cytidine deaminase (2.8- to 7.8-fold), deoxycytidylate deaminase (3.3- to 13.7-fold), and deoxycytidine kinase (1.6- to 6.7-fold) than [ 3 H]deoxycytidine in various normal and tumor tissues, H 4 Urd administration resulted in similar inhibitory effects. (
  • 0.05) modulated the lung, brain, kidney, liver and testis tissues antioxidant parameters as compared to the control. (
  • After the mice were killed, GFP-EPCs in different tissues were examined by fluorescence . (
  • The tumor tissues were stained for CD133, hypoxia -inducible factor-1alpha (HIF-1α), stromal cell -derived factor-1α (SDF-1α), and vascular endothelial growth factor receptor (KDR). (
  • Shikonin also increased RIP1 protein expression in tumor tissues. (
  • MicroCT was carried out with n=10 SPC-raf transgenic mice without gating in spontaneously breathing and isoflurane anaesthetised animals. (
  • To explore the potential of ASH1 to promote NE differentiation and tumorigenesis in the lung, we constitutively expressed the factor in nonendocrine airway epithelial cells using transgenic mice. (
  • These doubly transgenic animals developed massive NE lung tumors, implying that ASH1 may cooperate with defects in p53, pRb, or related pathways in promoting NE lung carcinogenesis. (
  • To define which cells respond to activated β-catenin during mammalian development, we generated the β-catenin-activated transgene driving expression of nuclear β-galactosidase reporter (BAT-gal) transgenic mice, expressing the lacZ gene under the control of β-catenin/T cell factor responsive elements. (
  • 6 ] demonstrated the activation of immature antigen presenting cells through TLR4 signaling correlated with increased serum interferon-gamma (IFN- γ ), interleukin-10 (IL-10), and anti-double-stranded deoxyribonucleic acid (anti-dsDNA) production in anti-dsDNA transgenic mice. (
  • 156 non contrast-enhanced respiratory gated micro-CT of the lungs were obtained in 12 SPC-raf transgenic (n = 9) and normal (n = 3) mice at different time points. (
  • In the SPC-c-Raf-1-BB (referred to as SPC-raf) transgenic mouse model overexpression of the serine-threonine-kinase c-raf to alveolar epithelium is achieved by use of the surfactant protein C (SPC) promoter. (
  • Essentially, the targeted overexpression in SPC-raf transgenic animals results in adenocarcinomas of the lung, with multifocal adenomatous hyperplasia being defined as the earliest proliferative lesion of dysplastic cells. (
  • Development of hypoxia in human solid tumors is due to rapid proliferation of tumor cells and the relative deficiency of blood distribution in the tumor mass [ 15 , 20 ], resulting in low oxygen levels in tumor cells, so-called hypoxic cells, located at a distance from the blood vessels [ 20 ]. (
  • Engineered knockdown of miR-31, but not other highlighted miRNAs, substantially repressed lung cancer cell growth and tumorigenicity in a dose-dependent manner. (
  • The findings of the present study reveal an important role of MMP-1 in OS primary tumor and metastasis formation to the lung, the major organ of OS metastasis. (
  • During this period, local gamma-irradiation of primary tumor (two or five fractions, each fraction of 10 Gy) has induced the retardation of tumor growth, and leucocytosis in tumor-bearing mice was diminished. (
  • Together, these findings revealed that miR-31 acts as an oncogenic miRNA (oncomir) in lung cancer by targeting specific tumor suppressors for repression. (
  • MicroRNAs ( miRNAs ) are small, non-protein-coding RNAs that can function as tumor suppressors or oncogenes. (
  • In the absence of Wnt stimulation, free β-catenin levels are kept low by a β-catenin degrading complex that includes the adenomatous polyposis coli (APC) and Axin tumor suppressors ( 1 , 5 ). (
  • Both p16 INK4A and p15 INK4B promote G 1 cell-cycle arrest by inhibiting the CDK4/CDK6 retinoblastoma family of tumor suppressors, whereas p14 ARF upregulates TP53 by inactivating its negative regulator MDM2 ( 10, 11 ). (
  • Transcriptome and immunohistochemical analyses reveal that PI3K pathway activation is unique to ERBB family tumors whereas KRAS-driven tumors show activation of the JNK/SAP pathway, suggesting points of therapeutic intervention for this difficult-to-treat tumor category. (
  • The results suggest that oral compounds may have therapeutic value for treating lung cancer in humans. (
  • Despite advances in therapeutic methods, the survival rates of lung cancer remain low. (
  • Therefore, identification of novel molecular abnormalities that contribute to lung cancer pathogenesis, patient outcome and therapeutic targets, is urgently needed to improve individualized treatment. (
  • Because bacteria are both inherently present and selectively grow within tumors, they provide a natural platform for the development of programmable therapeutic delivery vehicles. (
  • For their newly reported study, led by PhD student Candice Gurbatri, the investigators looked to engineer a translational therapeutic platform that improved upon a previous lysis circuit, and which would produce and release anti-PD-L1 and anti-CTLA-4 nanobodies directly in tumors. (
  • To test the protein's therapeutic potential, they treated mice with KRAS-driven lung cancer with amlexanox, a drug approved by the Food and Drug Administration as a paste to treat certain oral ulcers. (
  • TLR4 signal will be a therapeutic target in atherosclerosis and immune-mediated lung injury. (
  • and critically evaluate novel targets for imaging or therapeutic intervention that would be of use to the tumor microenvironment community and pharmaceutical industry. (
  • Commercial Biomedical Test Module - 2 (CBTM-2) uses a validated mouse model to examine the effectiveness of an experimental therapeutic as a possible countermeasure for muscle atrophy. (
  • Mice will be flown in space where half will be treated with the muscle therapeutic and half given a placebo. (
  • However, the increasing information on molecular pathways involved in the carcinogenesis of this canine tumor has potential to complement and refine the current diagnostic and therapeutic approach to this tumor type. (
  • Generation of a relevant mouse model is essential not only for the investigation of mechanism but also for testing potential therapeutic approaches. (
  • Thus, we studied "whole-life" inorganic arsenic carcinogenesis in mice at levels more relevant to humans. (
  • Point mutations of the K-ras gene and overexpression of cyclin D1 are thought to be early events during carcinogenesis of some types of lung cancer ( 3 , 4 ). (
  • Animal studies in a model of tobacco smoke carcinogenesis would thus have predicted the absence of any beneficial effects of β-carotene supplementation in current or former smokers, but would have failed to anticipate the increase in lung cancer risk. (
  • In this investigation, we used lung tumor susceptible A/J mice, a common animal model for lung carcinogenesis studies. (
  • We hypothesized that the hypoxic pulmonary microenvironment present in COPD would augment lung carcinogenesis. (
  • Mice were subjected to chemical carcinogenesis protocols and placed in either hypoxia or normoxia. (
  • We have evaluated the effects of hypobaric hypoxia on mouse lung carcinogenesis in response to 2 distinct chemical carcinogenesis models, both of which produce multiple primary lung tumors that do not commonly metastasize. (
  • This enables the assessment of tumour load and progress for the study of carcinogenesis and the evaluation of novel treatment strategies. (
  • The molecular carcinogenesis of canine mammary tumors are not completely understand. (
  • These data suggest that Parkin is a tumor suppressor gene whose inactivation may play an important role in non-small cell lung cancer tumorigenesis. (
  • Our findings constitute persuasive genetic evidence that Snf5, a core member of the Swi/Snf chromatin-remodeling complex, functions as a tumor suppressor gene, and, moreover, Snf5 heterozygotes provide a murine model of this lethal pediatric cancer. (
  • Experiments with HIF-2α deletion unexpectedly showed an increase in tumor burden, associated with a decrease in the candidate tumor suppressor gene Scgb3a1 , revealing the complexity of the relationship between HIF-2α expression and tumorigenesis, in which either up- or downregulation from basal expression can have similar effects ( 10 ). (
  • To overcome this issue, MIT scientists managed to encapsulate within special pods interleukins, drugs that promote proliferation of new T-cells, and attach these vehicles onto the backs of tumor hunting T-cells. (
  • Here, we show that the Ras inhibitor farnesylthiosalicylic acid (salirasib) inhibits proliferation of human lung cancer cells harboring a mutated K-ras gene (A549, H23, or HTB54) or overexpressing a growth factor receptor (H1299 or HTB58) and enhances the cytotoxic effect of the chemotherapeutic drug gemcitabine. (
  • Both lungs and tumors from hypoxic mice showed a preferential stabilization of HIF-2α and increased expression of VEGF-A, FGF2, and their receptors as well as other survival, proliferation, and angiogenic signaling pathways regulated by HIF-2α. (
  • The researchers found that, under these conditions, CD8+ T cells isolated from the prostate tumors no longer suppressed the proliferation of other T cells. (
  • Expression of RGS17 is required for maintenance of proliferation in lung tumor cell lines. (
  • Administration of DKK2 antibody inhibited cancer growth via modulating tumor immune microenvironment in lung cancer mouse models. (
  • This potent anti-tumor response was dependent on the tumor-host microenvironment, correlating with a diminished TGF-β production and an increase in inflammatory cytokines and MCP-1, and was associated with increased recruitment of lymphoid effector cells and diminished apoptosis. (
  • These studies showed that lung tumors arising in a hypoxic microenvironment express increased growth, angiogenic, and survival signaling that could contribute to the increased lung cancer risk in COPD. (
  • This volume covers the topics presented at the 3rd International Conference on Tumor Microenvironment and Cellular Stress by an international community of researchers. (
  • In the new research, Hurwitz's team found that CD8+ T cells acquire immune suppressive functions after they enter the mouse tumor microenvironment, which encompasses nearby noncancerous cells and immune cells in addition to tumor cells. (
  • Future work by this team will focus on defining the mechanisms by which tumor-specific CD8+ T cells gain their suppressive functions upon entering the mouse tumor microenvironment. (
  • Taken together, we showed here that miRNAs are deregulated during VC-induced mouse lung tumorigenesis and their levels are modulated by I3C. (
  • The increased persistence of GMA-SS fume in combination with its metal composition may trigger a chronic, but mild, inflammatory state in the lung possibly enhancing tumorigenesis in this susceptible mouse strain. (
  • Working in mouse models of lung cancer, the team found TANK-binding kinase 1 (TBK1) and its adaptor protein TBK-binding protein 1 (TBKBP1) contribute to tumorigenesis when they are activated by growth factors rather than by innate immune mechanisms. (
  • The identification of a common region of deletion in combination with the absence of or down-regulated expression in these tumors indicates that Parkin is targeted by LOH in lung tumorigenesis. (
  • Interestingly, however, owing to a sporadic ectopic Cre recombinase expression in the skin and lung of these mice, Fgfr3 mutation caused papilloma and promoted lung tumorigenesis in cooperation with K-Ras and β-catenin activation, respectively. (
  • Multiple i.p. injections of butylated hydroxytoluene did not significantly enhance the tumor yield. (
  • A compound that mimics the main protein in high-density lipoprotein (HDL, or "good") cholesterol significantly reduced the number of tumors in the lungs of mice, reports a team of UCLA researchers. (
  • After four weeks of treatment, the number of tumor nodules was significantly lower in the lungs of Tg6F-fed mice - on average, 75 percent lower than controls. (
  • We found that orthotopically injected Mvt1 cells gave rise to larger mammary tumors and to a significantly higher mean number of pulmonary macrometastases in hyperinsulinemic mice over a period of six weeks (hyperinsulinemic, 19.4 ± 2.7 vs. control, 4.0 ± 1.3). (
  • Upon intratibial injection into SCID mice, 143-B cells with shRNA-downregulated MMP-1 expression formed smaller primary tumors and significantly lower numbers of lung micro- and macrometastases than control cells. (
  • Tumor volumes were significantly reduced in a dose-dependent manner throughout the 6 week study and were associated with both a decrease in DNA synthesis and an increase in apoptosis. (
  • These studies also showed that exposure to hypoxia significantly increased the number of positive lymph nodes in mice, but not in lung metastasis nodule [ 27 , 28 ]. (
  • The heightened myeloid response was significantly correlated with tumor's volume increasing rate at the second week after tumor cells inoculation. (
  • Immunohistochemical analysis revealed that lung tumors from mice exposed to β-escin showed significantly reduced aldehyde dehydrogenase (ALDH)1A1 and phospho-Akt (p-Akt) expression when compared with those in mice fed control diet. (
  • Aldefluor assay for ALDH revealed that among H460 lung cancer cells treated with different concentrations of β-escin (0-40 μmol/L), the subpopulation of cells with elevated ALDH activity was inhibited significantly. (
  • In the weeks following, the treated mice had significantly smaller tumors and survived longer than the control mice. (
  • Using 34,774 joint profiles from mouse skin, we develop a computational strategy to identify cis-regulatory interactions and define domains of regulatory chromatin (DORCs) that significantly overlap with super-enhancers. (
  • However, when evaluating the expression of markers associated with classically activated (M1) macrophages, namely inducible nitric oxide synthase and IL‑12, it was observed that levels of M1 markers in the interstitial macrophages from asthmatic mice did not differ significantly to those in controls. (
  • Tumor growth was significantly lower in animals treated with shikonin than in the control group. (
  • Melanoma is a malignant skin tumor of melanocytic origin that can metastasize to any organ, including the brain and the lung ( 1 ). (
  • Malignant rhabdoid tumor (MRT) is an aggressive, highly lethal cancer of young children. (
  • Objective Radionuclide -labeled low molecular weight polypeptide is reeently advocated for the diagnosis and treatment of malignant tumor . (
  • Radiotherapy is used for the treatment of malignant tumors (cancer), and may be used as the primary therapy. (
  • The radiation fields may also include the draining lymph nodes if they are clinically or radiologically involved with tumour, or if there is thought to be a risk of subclinical malignant spread. (
  • Historically, about 50 percent of mammary tumors in dogs were found to be malignant, [9] although taking into account tumor behavior, one study has estimated true malignancy in mammary tumors to be 21 to 22 percent. (
  • Malignant mammary tumors are divided into sarcomas , carcinosarcomas , inflammatory carcinomas (usually anaplastic carcinomas ), and carcinomas (including adenocarcinomas ), which are the most common. (
  • They are the most malignant type of canine mammary tumor. (
  • Malignant tumors are also subdivided histopathologically into those showing blood vessel wall invasion and those that do not. (
  • [9] Metastasis for any malignant mammary tumor is usually to the regional lymph nodes and lungs . (
  • The tumor growth and metastasis were evaluated. (
  • Cytokines play an important role in controlling tumor growth and metastasis. (
  • Even if we clearly identify a mechanism behind tumour development, it is still extremely complex to pinpoint how to intervene in cells' internal machinery or modify genetic processes," explained Dr Soucek. (
  • Where mammary tumor cells were seen within alveolar air spaces, the tumor cells shared the same basement membrane with extant alveolar lining cells. (
  • Type A alveolar cells could not be identified within tumor cell-filled alveoli, but surviving type B alveolar cells were observed, although most appeared to be degenerating. (
  • To recapitulate the stochastic nature of human cancer development, we have devised a strategy for generating mouse tumor models that involves stepwise genetic manipulation of embryonic stem (ES) cells and chimera generation. (
  • Immune-cell therapy relies on modifying a patient's own T-cells to attack a specific tumor. (
  • The team used a mouse model of lung cancer, injecting cancer cells into the tail veins of mice. (
  • The cancerous cells migrate to the lungs, where they grow into tumors. (
  • The team also looked at how the compound was exerting its anti-cancer effects, and found that Tg6F altered lipid metabolism in the small intestine, which in turn altered gene expression and the type of immune cells present in both the intestine and the lung. (
  • Whether FTS can inhibit growth of lung cancer cells and tumor growth was not known. (
  • Mice bearing mammary tumors, induced by inoculation of syngeneic BALB/c mice with BJMC3879 cells, were treated with lovastatin at 0, 25 and 50 mg/kg three times a week. (
  • Rats bearing transplanted tumors consisting of A549 human lung cancer cells (lung cancer tumor) were exposed to hypoxia for different durations and different levels of oxygen. (
  • We also treated A549 lung cancer cells (A549 cells) with chronic hypoxia and then implanted the hypoxia-pretreated cancer cells into mice. (
  • A significant increase in perivascular/peribronchial lymphoid infiltrates for the GMA-SS group versus sham and an increased persistence of this fume in lung cells compared to the other welding fumes was found. (
  • The immunological finding accompanying this effect was the expansion of a newly described cell subset called IFN-γ producing killer dendritic cells associated with CD8 + T cell responses in the lung of EBI-3 −/− mice including IFN-γ release and TNF-α-induced programmed tumor cell death. (
  • Finally, adoptive transfer of EBI-3 −/− CD8 + T cells into tumor bearing wild-type mice inhibited lung metastasis in recipient mice. (
  • CLCF1 binds to and activates three proteins found on the surface of tumor cells, and together they work to promote the growth of lung cancer," said Sweet-Cordero, who sought out Cochran in 2013 to propose that they work together to thwart this process. (
  • The cancer begins in the lung's epithelial cells, which line the surface of the lungs. (
  • There are more than 7,000 compounds in tobacco smoke, many of which are carcinogens, or cancer-causing substances, that damage the cells lining the lungs upon inhalation. (
  • Furthermore, nicotine increases the production of α7-nAChR, and the more of these receptors there are for nicotine to bind to, the stronger the signaling cascade that encourages the growth of lung cancer cells among smokers. (
  • However, Wang and colleagues believe that BCX could be effective for reducing the amount of α7-nAChR receptors on the lungs, which could decrease the growth of lung cancer cells. (
  • Next, the researchers tested BCX on human lung cancer cells with and without α7-nAChR. (
  • They found that lung cancer cells with α7-nAChR were less likely to spread with BCX exposure, compared with lung cancer cells without the receptors. (
  • lung Clara cells and nasal olfactory cells (Cruzan et al . (
  • Moreover, CD69 is expressed by activated T, B, and NK cells and monocytes in LPS-treated mice ( 8 ). (
  • CD69−/− mice showed an enhanced NK cell-dependent response that leads to a higher protection and rejection of MHC class I − tumor cells compared with wild-type (WT) mice. (
  • Our work also provides the first evidence that TBK1 functions in cancer cells to mediate immunosuppression, suggesting that targeting TBK1 will both inhibit tumor growth and promote antitumor immunity," says senior author Shao-Cong Sun , Ph.D., professor of Immunology . (
  • KRAS-driven cancer is resistant to immune response, but the researchers found amlexanox sensitized tumors to blockade of the CTLA-4 checkpoint on immune T cells. (
  • Knocking down TBK1 in the KRAS-driven mouse model increased the frequency of effector CD4 helper T cells and CD8 cell-killing T cells in the lungs of the mice. (
  • A similar experiment in another mouse model also reduced the frequency of immune-suppressing myeloid-derived suppressor cells. (
  • Additional experiments implicated TBK1 in promotion of glycolysis - a sugar-burning metabolic process that also suppresses the immune system - and the increased presence of PD-L1, a protein on tumor cells that turns off attacking T cells by connecting with the PD-1 protein on their cell surface. (
  • 60% tumor cells were used. (
  • 3 ] indicated the pathogenesis of AH was implicated in B cells as evidenced by reduced AH prevalence in Rag1 −/− or Igmu −/− mice following pristane injection. (
  • Female C57BL/6 mice were obtained at 6-8 weeks of age and were implanted with 5×10 5 LN7 tumor cells by dorsal subcutaneous injection in the upper back. (
  • When mice bearing established 3LL tumors were pretreated with docetaxel followed by vaccination with irradiated GM-CSF- transduced 3LL tumor cells, significant tumor regression and prolonged survival were observed compared with chemotherapy alone. (
  • Mice that survived treatment were able to resist a lethal rechallenge of 3LL tumor cells. (
  • Thus, augmentation of vaccine induced antitumor immunity in docetaxel-treated mice primarily due to the enhanced survival of antigen-experienced T cells. (
  • Primary mutant Kras lung epithelial cells lacking Cdkn2ab had increased clonogenic potential. (
  • Furthermore, comparative analysis of mutant Kras;Cdkn2a null with Kras;Cdkn2ab null mice and experiments with mutant KRAS;CDKN2AB -deficient human lung cancer cells indicated that p15INK4B is a critical tumor suppressor. (
  • The underlying cause appears to be a high metabolic activity of mouse lung, due to relatively high abundance of Clara cells in mice compared with humans and the mouse-specific cytochrome P450 isoform 2f2 in the Clara cells. (
  • Ehrlich Ascites Tumor (EAT) cells (1x106 EAT cell) from the stock animal were injected into all the mice in an intraperitoneal way. (
  • Our study showed the anti-tumor effect of C. mas L. in assisted tumor development with EAT cells, conceivably moderated by the enhancement of oxidative stress due to numerous mechanisms. (
  • Endothelial progenitor cells (EPCs) play an important role in hypoxia -triggered tumor vasculogenesis. (
  • Further investigation revealed a critical role of tumor-derived TGF-β in converting CD4 + CD25 − T cells into T reg cells because a neutralizing Ab against TGF-β, 1D11, completely abrogated the induction of T reg cells. (
  • CM from a nontumorigenic cell line, NRP-152, or irradiated tumor cells did not convert CD4 + CD25 − T cells to T reg cells because they produce low levels of TGF-β in CM. Finally, we observed a reduced tumor burden in animals receiving 1D11. (
  • In summary, we have demonstrated that tumor cells directly convert CD4 + CD25 − T cells to T reg cells through production of high levels of TGF-β, suggesting a possible mechanism through which tumor cells evade the immune system. (
  • Tumor-infiltrating lymphocytes (TILs) 2 were identified in both human and murine tumors and were shown to recognize and reject tumor cells in immunotherapy ( 4 , 6 ). (
  • Medical Xpress)-French researchers have developed a new radiation technique that appears to target tumour cells while leaving healthy cells unharmed, according to a new study in mice. (
  • Our findings suggest that β-escin inhibits tobacco carcinogen-induced lung tumor formation by modulating ALDH1A1-positive cells and RhoA/Rock signaling. (
  • Cancer stem cells have been isolated from human lung cancer and cancer cell lines. (
  • Real-time monitoring of biologic changes in tumors may be possible by investigating the transitional cells such as circulating tumor cells (CTCs) and disseminated tumor cells in bone marrow (BM-DTCs). (
  • Researchers have discovered that prostate tumors in mice can cause immune cells known as CD8+ T cells to change their function from cells that have antitumor activity to cells that suppress immune responses. (
  • The conversion of CD8+ T cells into suppressor cells may be one of the mechanisms by which tumors restrict the immune system's ability to control tumor growth," said Arthur A. Hurwitz, Ph.D., head of the Tumor Immunity and Tolerance Group at NCI's Center for Cancer Research. (
  • CD8+ T cells also play a role in immune responses against tumor cells. (
  • Moreover, research in mice has shown that blocking the immune suppressive activity of these regulatory T cells enhances the body's immunity against tumors, causing tumor growth to slow and improving the antitumor immune responses elicited by cancer vaccines. (
  • Recent evidence in mice has suggested that CD8+ T cells can develop suppressive activities similar to those of CD4+ T regulatory cells. (
  • The presence of these suppressor cells could explain earlier findings by Hurwitz's team that prostate tumor-specific CD8+ T cells injected into prostate tumor-bearing mice migrate to the tumors but then become unresponsive, or tolerized, to the tumor cells. (
  • It remained unclear, however, whether the suppressive CD8+ T cells have suppressor activity before they reach the tumor or whether they are converted into suppressor cells by the tumor. (
  • The researchers found that tumor-specific CD8+ T cells isolated from the tumors were able to suppress the proliferative capacity of nonspecific T cells, whereas tumor-specific CD8+ T cells isolated from lymph nodes of the mice were unable to do so. (
  • Next, the team investigated whether the conversion of tumor-specific CD8+ T cells to suppressor cells could be prevented. (
  • To do this, they administered tumor-specific CD4+ and CD8+ T cells to prostate tumor-bearing mice. (
  • The researchers propose that activated CD4+ T cells that enter tumors may secrete factors that support the CD8+ T cell antitumor functions, or may help other immune cells located in the tumor block the processes by which CD8+ T cells acquire their suppressive activity. (
  • In addition, the research shows that when such drugs are packaged into nanoparticles that target lit-up cancer cells , the light-sensitive drug produces toxic free radicals that kill the tumor cells . (
  • Energy-hungry cancer cells take up the FDG at high rates, causing tumors to glow in a positron emission tomography (PET) scan. (
  • Despite the fact that SCLC cell lines expressed little or no cytosolic phospholipase A 2 , COX-1, or COX-2, sulindac sulfide and PPARγ agonists also inhibited the transformed growth of these lung cancer cells. (
  • Serum autoantibody of antinuclear antibody (ANA), anti-double-stranded DNA (anti-dsDNA), and cytokines of interferon-gamma (IFN- γ ), tumor necrosis factor (TNF- α ), and interleukin-1 (IL-1 β ) were assessed by ELISA. (
  • We propose that the proinflammatory cytokines tumor necrosis factor-alpha (TNFα) and interferon-gamma (IFNγ) contribute to the WA1-associated disease. (
  • Hemmer, RM, Ferrick, DA & Conrad, PA 2000, ' Up-regulation of tumor necrosis factor-alpha and interferon-gamma expression in the spleen and lungs of mice infected with the human Babesia isolate WA1 ', Parasitology Research , vol. 86, no. 2, pp. 121-128. (
  • Microarray analysis revealed significant induction of tumor necrosis factor ( TNF )-α-induced protein 6 ( TNFAIP6/ TSG-6) expression by hMSCs 12 h after OA delivery to LPS-exposed lungs. (
  • Tumor growth in A549 and HTB58 cell nude mouse models was inhibited by i.p. administration of salirasib. (
  • P.o. formulated salirasib also inhibited A549 cell tumor growth. (
  • FTS (salirasib) inhibited A549 lung cancer cell tumor growth. (
  • In previous research, Wang and team observed a link between the consumption of BCX-rich foods and a lower risk of lung cancer in humans. (
  • While further research is required to gain a better understanding of how BCX might impact lung cancer development in humans, Wang and colleagues believe that individuals exposed to tobacco smoke might benefit from consuming foods rich in BCX. (
  • Rats have lower metabolic activity than mice (already below the threshold needed to cause lung tumors upon lifetime exposure) and activity in humans is lower than in rats. (
  • In mice and humans, when the immune system encounters a pathogen or other foreign invader, it responds by mounting an immune response. (
  • For mammary tumors in humans, see breast cancer . (
  • There are many differences between mammary tumors in animals and breast cancer in humans, including tumor type, malignancy , and treatment options. (
  • RGS17 is a putative lung cancer susceptibility gene in the lung cancer associated locus on chromosome 6q in humans. (
  • Adenomatous polyposis coli ( APC ) and KRAS proto-oncogene ( KRAS ) mutations frequently co-occur in non-small cell lung cancer. (
  • However, it remains undetermined whether such approaches are also applicable to non-small cell lung cancer patients harboring similar mutations of APC . (
  • This study aimed to investigate the potential of applying anti-DKK2 antibody to non-small cell lung cancer with APC mutations. (
  • Our study provided strong evidence supporting APC mutations-directed applications of anti-DKK2 targeted therapy in a wide range of cancer types, including lung cancer. (
  • A new paper in PNAS reports that three common chemotherapy drugs destabilize DNA in mice enough to trigger new mutations long after exposure to the drugs has ceased-mutations which are then passed down to their untreated offspring. (
  • DNA mutations tend to accumulate in the genomes of offspring mice more than in their parents. (
  • They first found that knocking out TBK1 in a mouse model designed to spontaneously develop lung cancer driven by KRAS mutations sharply reduced the number and size of tumors. (
  • The majority of MRT samples and cell lines have sustained biallelic inactivating mutations of the hSNF5 (integrase interactor 1) gene, suggesting that hSNF5 may act as a tumor suppressor. (
  • Activating mutations of KRAS occur in approximately 30% of lung adenocarcinomas. (
  • however, it is not sufficient for the induction of high-grade lung adenocarcinomas in the absence of cooperating mutations that often involve the CDKN2AB locus ( 6-9 ). (
  • We will also discuss the possible implications of diverse IL-33 mutations and isoforms in the anti-tumor activity of the cytokine and as possible clinical biomarkers. (
  • The exact causes for the development of canine mammary tumors are not fully understood. (
  • Female dogs who are not spayed or who are spayed later than the first heat cycle are more likely to develop mammary tumors. (
  • The average age of dogs with mammary tumors is ten to eleven years old. (
  • [8] There are several hypotheses on the molecular mechanisms involved in the development of canine mammary tumors but a specific genetic mutation has not been identified. (
  • Now, in a new study in the journal Cancer Cell , Shaw and a team of scientists at the Salk Institute for Biological Studies found that phenformin, a derivative of the widely-used diabetes drug metformin, decreased the size of lung tumors in mice and increased the animals' survival. (
  • Mice injected with amlexanox had a steep reduction in the number and size of lung tumors. (
  • The mice with breast cancer also showed an anti-tumor effect when treated using this strategy, though less pronounced than in those with multiple myeloma, likely due to the extreme aggressiveness of the breast cancer cell line, according to the researchers. (
  • In the new study, the researchers set out to determine whether and how the compound, called Tg6F, might alter the immune system both in the intestine and in a distant organ (in this case, the lung). (
  • We focus on immune and metabolic aspects of tumors, whose alterations could influence tumor development profoundly. (
  • Multi-parameter flow cytometry combined with unbiased analyses enabled to identify immune signatures clustering tumors in function of their aggressiveness, immunogenicity or prior chemotherapy treatment. (
  • Additionally, our results highlighted neutrophils as an important immune cell type in lung tumors. (
  • Researchers at Columbia University Department of Biomedical Engineering have engineered a novel probiotic strain of bacteria that can safely deliver immune checkpoint inhibiting nanobodies directly to tumors. (
  • When tested in cancer-bearing mice, a single dose of the bacteria continuously produced and released the anti-PD-L1 and anti-CTLA-4 nanobodies, triggering an immune response that led to tumor regression. (
  • For instance, IFN-γ is a pleiotropic cytokine whose production relates to Th1 immune responses against pathogens and tumors. (
  • The immune response against tumors involves the combined action of humoral and cellular mechanisms, in which macrophages, cytotoxic T, and NK lymphocytes play a central role. (
  • Tumor models have provided useful tools to dissect complex anti-tumor immune responses ( 21 , 22 ). (
  • Treatment with amlexanox and anti-CTLA-4 immunotherapy stimulated immune response and reduced tumor size and frequency in the mouse models. (
  • A key aspect of tumor immunology is immune surveillance in the tumor-bearing host. (
  • Studying this process in mice may help explain why some cancer patients have an initial response from their immune-based therapy, but this response fails with time. (
  • Sixteen days after mice with lung and bone marrow tumors were subjected to the treatment their tumors disappeared entirely. (
  • Nevertheless, CD69 does not appear to be required for the development of any bone marrow cell lineage because nearly normal hematopoietic cell development and T cell maturation occur in CD69−/− mice. (
  • Only minor alterations are observed in B cell development in these mice, with the B220 hi IgM neg bone marrow pre-B cell compartment slightly augmented ( 4 ). (
  • To better understand how human MSCs (hMSCs) may act in ALI, the lungs of immunocompetent mice were exposed to lipopolysaccharide (LPS) and four hours later bone marrow derived hMSCs were delivered by oropharyngeal aspiration (OA). (
  • Under fluorescence microscope, GFP-EPCs were strongly expressed in both tumor and bone marrow . (
  • Except tumor , bone marrow can also recruit EPCs. (
  • CTCs and BM-DTCs, isolated from BC PDX-bearing mice, were identified by immunostaining for human pan-cytokeratin and nuclear counterstaining of red blood cell-lysed blood and bone marrow fractions, respectively. (
  • Our study shows that this phototherapeutic technology is particularly suited to attacking small tumors that spread to different parts of the body, including deep in the bone marrow. (
  • Gene expression profiles of four murine tumors after carbon-ion (C-ion) or gamma irradiation. (
  • Different imaging modalities have been reported and their advantages and disadvantages have been evaluated for imaging of murine lung pathology. (
  • Chimeric mouse tumor models reveal differences in pathway activation between ERBB family- and KRAS-dependent lung adenocarcinomas. (
  • Adenocarcinomas arising in an allelic series of lung cancer models containing HER2 (also known as ERBB2), KRAS or EGFR oncogenes exhibit features of advanced malignancies. (
  • Chimeric mouse models for lung adenocarcinomas. (
  • Further, the lung tumors in the A/J mouse display many morphological, histopathological, and molecular similarities to human pulmonary adenocarcinomas, which makes them a relevant model for lung cancer research [ 12 , 13 ]. (
  • The high dose of lovastatin also inhibited lung metastasis. (
  • Lung adenomas were induced in 8-wk old female strain A/J mice by three oral gavages of B[a]P (2 mg /0.2 ml cotton seed oil). (
  • Fluorescence immunohistochemistry (IHC) of lung adenomas from NNK-treated mice and tumors from lung cancer patients that were smokers were characterized by disruption of the DNMT1/βTrCP interaction and DNMT1 nuclear accumulation. (
  • Budesonide decreased the proliferating cell nuclear antigen labeling in lung adenomas, carcinomas, parenchyma and bronchial airways by 87.6, 59.0, 41.1 and 25.4%, respectively. (
  • A daily dose of 870 micrograms of BCX - the equivalent to the human consumption of around one sweet pepper or two tangerines - was found to be the most effective in reducing lung tumor growth, the team reports. (
  • These results are hugely positive for us, because one year of life in a mouse is equivalent to almost 40 human years. (
  • Thus, in CD1 mice whole-life arsenic exposure induced lung tumors at human-relevant doses (i.e., 50 and 500 ppb). (
  • Using a bioinformatics approach, we identified miR-31 target mRNAs and independently confirmed them as direct targets in human and mouse lung cancer cell lines. (
  • Mice are one of the most extensively used animal models for studying human disease because they represent a highly controllable experimental model system. (
  • Here we used human and mouse lung cancer samples and cell lines to determine a mechanism whereby NNK induced DNMT1 expression and activity. (
  • We determined that in a human lung cell line, glycogen synthase kinase 3β (GSK3β) phosphorylated DNMT1 to recruit β-transducin repeat-containing protein (βTrCP), resulting in DNMT1 degradation, and that NNK activated AKT, inhibiting GSK3β function and thereby attenuating DNMT1 degradation. (
  • We demonstrate relevance to human lung cancer of the protein signatures identified on the basis of mouse models. (
  • In human clinical trials it was found that the putative chemopreventive agent β-carotene not only failed to protect active smokers against the carcinogenic action of tobacco smoke, but actually increased their risk of developing lung cancer. (
  • Differential transcriptomic analysis of spontaneous lung tumors in B6C3F1 mice: comparison to human non-small cell lung cancer. (
  • Study co-author Xiang-Dong Wang, of the Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University in Boston, MA, and colleagues say that their results indicate that eating fruits and vegetables high in BCX might reduce the risk of lung cancer caused by smoking. (
  • icologic and metabolic data that explain the nasal and major differences are 4- to 10-fold more ring-oxidation lung differences and their relevance for human risk and phenylacetaldehyde pathways in mice compared assessment. (
  • The genetic and biochemical characteristics of mouse CD69 are very similar to its human homologue. (
  • Knockdown in a human lung cancer line promoted programmed cell death and suppressed tumor growth. (
  • This preclinical mouse model, therefore, recapitulates the molecular changes responsible for resistance to TKIs in human tumors and holds promise for the discovery of additional mechanisms of drug resistance in lung cancer. (
  • These similarities between the animal models and the human disease prompted us to test whether long-term erlotinib treatment of mutant EGFR -driven lung tumors in mice would lead to the emergence of drug-resistant tumors that could then provide further insight into the molecular basis of TKI resistance in human patients. (
  • To determine the frequency of CDKN2AB loss in human mutant KRAS lung cancer, The Cancer Genome Atlas (TCGA) database was interrogated. (
  • The carcinogenic risk for human lung is low for this mode of action (MOA). (
  • Fluensulfone is extensively metabolized by mouse lung microsomes, whereas no metabolic activity is seen with human lung microsomes. (
  • We concluded that fluensulfone leads to species-specific mouse lung tumors and that these tumors are likely not relevant to human hazard or risk. (
  • In addition, intra-pulmonary delivery of recombinant human TSG-6 reduced LPS-induced inflammation in the lung. (
  • and its possible mode of action was evaluated using the H460 human lung cancer cell line. (
  • This will enhance our ability to generate more effective antitumor T cell responses in mice, which then might be translated to human. (
  • and epidemiological studies indicating that NSAIDs decrease the risk for developing lung cancer ( Schreinemachers and Everson, 1994 ) are consistent with an emerging role for eicosanoid biosynthetic pathways in human cancer development. (
  • Intrapleural ( administration of LC 9018 was effective in inhibiting pulmonary metastasis after s.c. inoculation of 3LL tumors into C57BL/6 mice. (
  • Our objectives were then to examine whether FTS can exert anti-Ras activity in lung cancer cell lines and inhibit their growth in vitro and in animals. (
  • Cox-2 and 5-Lox at 2 weeks, survivin, PCNA and apoptosis at 16 weeks) in lung was evaluated by Western Blot and immunohistochemistry. (
  • The whole-body exposure of C57BL/6 mice to ECS for 6 months failed to induce any lung tumor but caused alopecia, gray hair, and hair bulb cell apoptosis, which were prevented by the oral administration of N-acetylcysteine. (
  • Resistance of CD69−/− mice to MHC class I − tumor growth was also associated with increased production of the chemokine MCP-1, diminished TGF-β production, and decreased lymphocyte apoptosis. (
  • The tumor cell cycle and cell apoptosis were analyzed by flow cytometry (FCM), terminal deoxynucleotidyl transferase mediated dUTP-biotion nick end labeling ( TUNEL ) and histopathological analysis . (
  • Our findings demonstrate the prospects for using dense SNP maps in laboratory mice to refine previous QTL regions and identify genetic determinants of complex traits. (
  • The harmful health effects of welding are well documented and epidemiological evidence generally supports the hypothesis that exposure to welding fume increases lung cancer risk, but confounders such as asbestos exposure and smoking obscure these findings [ 2 - 5 ]. (
  • To reach their findings, the researchers gave two groups of mice a daily injection of a carcinogen derived from nicotine. (
  • However, the divergent findings on this comorbidity of autoimmune disorder, atherosclerosis, and lung inflammation highlight the considerable heterogeneity. (
  • The whole-body exposure of Aroclor-treated A/J mice to ECS resulted in a rapid and potent induction of micronuclei in peripheral blood erythrocytes. (
  • Casc1 knockout mouse tumor bioassays showed that Casc1-deficient mice were susceptible to chemical induction of lung tumors. (
  • The purpose of the present study was to compare the dose-response relationships for the induction of lung tumors in RFM mice after localized thoracic exposures to X rays or fission neutrons. (
  • 0.05) of doxorubicin in athymic BALB/c nu/nu mice together with a strong prevention of doxorubicin-caused adverse health effects. (
  • In our study, 32 Balb/C type male mice were used. (
  • Due to the multiple very small tumor nodules that occur and the low signal-to-noise ratio direct volumetric measurement of solitary tumor nodules is not feasible. (
  • When possible, mice with clearly discernible tumor nodules and/or consolidations involving a whole lung lobe were selected for treatment. (
  • We used these images to measure tumor volume in mice in which dense consolidations and/or tumor nodules could easily be demarcated and distinguished from the heart ( supplementary material Table S1). (
  • Although multiple tumor nodules were generally observed in each mouse at the time of necropsy, only the largest one or two were amenable to tumor volume measurements using MRI. (
  • Increasing evidences indicate that IL-33 may have opposing functions, promoting, or dampening tumor immunity, depending on the tumor type, site of expression, and local concentration. (
  • The whole-body exposure of SKH-1 hairless mice to ECS for 6 months, followed by exposure to halogen light for 8 months, resulted in the formation of multiple skin tumors but failed to produce lung tumors. (
  • These data suggest that COPS3 may promote tumor growth by regulating cell-cycle associated proteins. (
  • In a series of experiments, the researchers showed that TBK1 and TBKBP1 form a growth factor signaling axis that activates mTORC1 to promote tumor development. (
  • We investigated the potential of in-depth quantitative proteomics to reveal plasma protein signatures that reflect lung tumor biology. (
  • We compared plasma protein profiles of four mouse models of lung cancer with profiles of models of pancreatic, ovarian, colon, prostate, and breast cancer and two models of inflammation. (
  • Researchers at Stanford and UCSF slowed the spread of a type of nonsmall cell lung cancer in mice by neutralizing a single protein that would otherwise set off a chain reaction, causing runaway tumor growth. (
  • A paper published online on Nov. 7 in Nature Medicine reports that the researchers slowed the spread of this cancer in mice by neutralizing a single protein that would otherwise set off a chain reaction, causing runaway growth. (
  • In 2012, he published a paper showing how a protein called CLCF1 initiated a chain of events that accelerated growth in one of the three main variants of nonsmall cell lung cancer. (
  • New research from the University of British Columbia suggests that reducing mutated Huntington disease protein in the brain can restore cognitive and psychiatric impairments in mice. (
  • The effect of hMSCs on lung injury was assessed by measuring the lung wet/dry weight ratio and total protein in bronchoalveolar lavage (BAL) fluid 24 or 48 h after LPS. (
  • After three weeks of treatment, Shaw and his team saw a modest reduction in tumor burden in the mice. (
  • The reduction in tumor burden correlated with a decrease in tumor-derived TGF-β. (
  • Treatment of EGFR(L858R) and KRAS(G12V) chimeric models with an EGFR inhibitor resulted in near complete tumor regression and no response to the treatment, respectively, accurately reflecting previous clinical observations. (
  • Mice that conditionally express both a nondegradable variant of HIF-2α and a mutant form of Kras (Kras G12D ) in the lungs developed larger and more invasive tumors had an increased tumor burden and decreased survival compared with mice expressing only Kras G12D ( 9 ). (
  • Loss of Cdkn2ab results in aggressive lung cancer in an oncogenic Kras conditional mouse. (
  • In the study, the researchers tested phenformin as a chemotherapy agent in genetically-engineered mice lacking LKB1 and which had advanced stage lung tumors. (
  • In addition, tumor patients treated with proinflammatory cytokines show increased levels of immunosuppressive cytokines (e.g. (
  • We found that serum autoantibody (ANA and anti-dsDNA), cytokines (IFN- γ , TNF- α , IL-1 β ), lung inflammation, and intima-media thickness in brachiocephalic artery were obviously increased after LPS challenge in both genotypes, but to a lesser extent in wild-type strains. (
  • Immunohistochemical staining confirmed the up-regulation of these proinflammatory cytokines in the lungs. (
  • In this study, we assessed the role of EBI-3 in a model of lung melanoma metastasis. (
  • The current study evaluated the chemopreventive efficacy and mechanism of Licofelone, a dual inhibitor of cyclooxygenase-2 (Cox-2) and 5-lipoxygenase (5-Lox), against the strain A/J mouse lung adenoma induced by benzo[a]pyrene (B[a]P). The Licofelone was administered to the lung via oropharyngeal aspiration. (
  • To investigate the pathologic mechanisms of toll-like receptor 4 (TLR4) in lung injury and atherosclerosis, ApoE −/− or wild-type mice were intraperitoneally administered saline, lipopolysaccharides (LPS), or LPS plus TAK-242 (TLR4 inhibitor), respectively, twice a week for 4 weeks. (
  • We exposed male A/J and C57BL/6J, a lung tumor resistant strain, by pharyngeal aspiration four times (once every 3 days) to 85 μg of gas metal arc-mild steel (GMA-MS), GMA-stainless steel (SS), or manual metal arc-SS (MMA-SS) fume, or to 25.5 μg soluble hexavalent chromium (S-Cr). (
  • Compared to the essentially lung tumor resistant C57BL/6J strain, A/J mice exhibit high susceptibility to spontaneous and chemically induced lung tumors [ 11 ]. (
  • Ever since discovering a decade ago that a gene altered in lung cancer regulated an enzyme used in therapies against diabetes, Reuben Shaw has wondered if drugs originally designed to treat metabolic diseases could also work against cancer. (
  • We induced Omomyc expression in mice through gene therapy and managed to activate and deactivate it by administering an antibiotic to the mice in their drinking water. (
  • We examined 20 paired normal and non-small cell lung cancer samples for the presence of Parkin alterations in the coding sequence and changes in gene expression. (
  • We focus on mouse models in order to employ novel genetic tools to regulate gene function in developing cancerous lesions as well as to track cancer growth and dissemination via bioluminescent and fluorescent techniques. (