Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.Mortality: All deaths reported in a given population.Hospital Mortality: A vital statistic measuring or recording the rate of death from any cause in hospitalized populations.Infant Mortality: Postnatal deaths from BIRTH to 365 days after birth in a given population. Postneonatal mortality represents deaths between 28 days and 365 days after birth (as defined by National Center for Health Statistics). Neonatal mortality represents deaths from birth to 27 days after birth.Cause of Death: Factors which produce cessation of all vital bodily functions. They can be analyzed from an epidemiologic viewpoint.Child Mortality: Number of deaths of children between one year of age to 12 years of age in a given population.Maternal Mortality: Maternal deaths resulting from complications of pregnancy and childbirth in a given population.Cohort Studies: Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Shock, Septic: Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include, but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Infant, Newborn: An infant during the first month after birth.Survival Analysis: A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Survival Rate: The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.Proportional Hazards Models: Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.United StatesMultiple Organ Failure: A progressive condition usually characterized by combined failure of several organs such as the lungs, liver, kidney, along with some clotting mechanisms, usually postinjury or postoperative.Systemic Inflammatory Response Syndrome: A systemic inflammatory response to a variety of clinical insults, characterized by two or more of the following conditions: (1) fever >38 degrees C or HYPOTHERMIA 90 beat/minute; (3) tachypnea >24 breaths/minute; (4) LEUKOCYTOSIS >12,000 cells/cubic mm or 10% immature forms. While usually related to infection, SIRS can also be associated with noninfectious insults such as TRAUMA; BURNS; or PANCREATITIS. If infection is involved, a patient with SIRS is said to have SEPSIS.Risk Assessment: The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Incidence: The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.Intensive Care Units: Hospital units providing continuous surveillance and care to acutely ill patients.Age Factors: Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.Cardiovascular Diseases: Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.Mortality, Premature: Deaths that occur before LIFE EXPECTANCY is reached within a given population.Cecum: The blind sac or outpouching area of the LARGE INTESTINE that is below the entrance of the SMALL INTESTINE. It has a worm-like extension, the vermiform APPENDIX.Punctures: Incision of tissues for injection of medication or for other diagnostic or therapeutic procedures. Punctures of the skin, for example may be used for diagnostic drainage; of blood vessels for diagnostic imaging procedures.Perinatal Mortality: Deaths occurring from the 28th week of GESTATION to the 28th day after birth in a given population.Critical Illness: A disease or state in which death is possible or imminent.Severity of Illness Index: Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.APACHE: An acronym for Acute Physiology and Chronic Health Evaluation, a scoring system using routinely collected data and providing an accurate, objective description for a broad range of intensive care unit admissions, measuring severity of illness in critically ill patients.Postoperative Complications: Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Predictive Value of Tests: In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.Age Distribution: The frequency of different ages or age groups in a given population. The distribution may refer to either how many or what proportion of the group. The population is usually patients with a specific disease but the concept is not restricted to humans and is not restricted to medicine.Sex Factors: Maleness or femaleness as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or effect of a circumstance. It is used with human or animal concepts but should be differentiated from SEX CHARACTERISTICS, anatomical or physiological manifestations of sex, and from SEX DISTRIBUTION, the number of males and females in given circumstances.Death Certificates: Official records of individual deaths including the cause of death certified by a physician, and any other required identifying information.Fetal Mortality: Number of fetal deaths with stated or presumed gestation of 20 weeks or more in a given population. Late fetal mortality is death after of 28 weeks or more.Morbidity: The proportion of patients with a particular disease during a given year per given unit of population.Registries: The systems and processes involved in the establishment, support, management, and operation of registers, e.g., disease registers.Multivariate Analysis: A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.Sex Distribution: The number of males and females in a given population. The distribution may refer to how many men or women or what proportion of either in the group. The population is usually patients with a specific disease but the concept is not restricted to humans and is not restricted to medicine.Length of Stay: The period of confinement of a patient to a hospital or other health facility.Biological Markers: Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.Kaplan-Meier Estimate: A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)Risk: The probability that an event will occur. It encompasses a variety of measures of the probability of a generally unfavorable outcome.Logistic Models: Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.Life Expectancy: Based on known statistical data, the number of years which any person of a given age may reasonably expected to live.Poisson Distribution: A distribution function used to describe the occurrence of rare events or to describe the sampling distribution of isolated counts in a continuum of time or space.Myocardial Infarction: NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).Regression Analysis: Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.Infant, Newborn, Diseases: Diseases of newborn infants present at birth (congenital) or developing within the first month of birth. It does not include hereditary diseases not manifesting at birth or within the first 30 days of life nor does it include inborn errors of metabolism. Both HEREDITARY DISEASES and METABOLISM, INBORN ERRORS are available as general concepts.Bacteremia: The presence of viable bacteria circulating in the blood. Fever, chills, tachycardia, and tachypnea are common acute manifestations of bacteremia. The majority of cases are seen in already hospitalized patients, most of whom have underlying diseases or procedures which render their bloodstreams susceptible to invasion.Comorbidity: The presence of co-existing or additional diseases with reference to an initial diagnosis or with reference to the index condition that is the subject of study. Comorbidity may affect the ability of affected individuals to function and also their survival; it may be used as a prognostic indicator for length of hospital stay, cost factors, and outcome or survival.Ligation: Application of a ligature to tie a vessel or strangulate a part.Intensive Care: Advanced and highly specialized care provided to medical or surgical patients whose conditions are life-threatening and require comprehensive care and constant monitoring. It is usually administered in specially equipped units of a health care facility.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Endotoxemia: A condition characterized by the presence of ENDOTOXINS in the blood. On lysis, the outer cell wall of gram-negative bacteria enters the systemic circulation and initiates a pathophysiologic cascade of pro-inflammatory mediators.Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.Anti-Bacterial Agents: Substances that reduce the growth or reproduction of BACTERIA.Peritonitis: INFLAMMATION of the PERITONEUM lining the ABDOMINAL CAVITY as the result of infectious, autoimmune, or chemical processes. Primary peritonitis is due to infection of the PERITONEAL CAVITY via hematogenous or lymphatic spread and without intra-abdominal source. Secondary peritonitis arises from the ABDOMINAL CAVITY itself through RUPTURE or ABSCESS of intra-abdominal organs.Epidemiologic Methods: Research techniques that focus on study designs and data gathering methods in human and animal populations.Bacterial Infections: Infections by bacteria, general or unspecified.Renal Dialysis: Therapy for the insufficient cleansing of the BLOOD by the kidneys based on dialysis and including hemodialysis, PERITONEAL DIALYSIS, and HEMODIAFILTRATION.Pneumonia: Infection of the lung often accompanied by inflammation.Burns: Injuries to tissues caused by contact with heat, steam, chemicals (BURNS, CHEMICAL), electricity (BURNS, ELECTRIC), or the like.Acute Disease: Disease having a short and relatively severe course.Acute Kidney Injury: Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.Odds Ratio: The ratio of two odds. The exposure-odds ratio for case control data is the ratio of the odds in favor of exposure among cases to the odds in favor of exposure among noncases. The disease-odds ratio for a cohort or cross section is the ratio of the odds in favor of disease among the exposed to the odds in favor of disease among the unexposed. The prevalence-odds ratio refers to an odds ratio derived cross-sectionally from studies of prevalent cases.Critical Care: Health care provided to a critically ill patient during a medical emergency or crisis.Gram-Negative Bacterial Infections: Infections caused by bacteria that show up as pink (negative) when treated by the gram-staining method.EnglandKidney Failure, Chronic: The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.Confidence Intervals: A range of values for a variable of interest, e.g., a rate, constructed so that this range has a specified probability of including the true value of the variable.Lipopolysaccharides: Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed)Calcitonin: A peptide hormone that lowers calcium concentration in the blood. In humans, it is released by thyroid cells and acts to decrease the formation and absorptive activity of osteoclasts. Its role in regulating plasma calcium is much greater in children and in certain diseases than in normal adults.Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.Occupational Diseases: Diseases caused by factors involved in one's employment.Chi-Square Distribution: A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.WalesPopulation Surveillance: Ongoing scrutiny of a population (general population, study population, target population, etc.), generally using methods distinguished by their practicability, uniformity, and frequently their rapidity, rather than by complete accuracy.Longitudinal Studies: Studies in which variables relating to an individual or group of individuals are assessed over a period of time.Prevalence: The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.JapanInfection: Invasion of the host organism by microorganisms that can cause pathological conditions or diseases.Randomized Controlled Trials as Topic: Works about clinical trials that involve at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table.Smoking: Inhaling and exhaling the smoke of burning TOBACCO.Coronary Disease: An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.SwedenMice, Inbred C57BLDeveloping Countries: Countries in the process of change with economic growth, that is, an increase in production, per capita consumption, and income. The process of economic growth involves better utilization of natural and human resources, which results in a change in the social, political, and economic structures.Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.European Continental Ancestry Group: Individuals whose ancestral origins are in the continent of Europe.Stroke: A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)Spain: Parliamentary democracy located between France on the northeast and Portugual on the west and bordered by the Atlantic Ocean and the Mediterranean Sea.Intensive Care Units, Neonatal: Hospital units providing continuing surveillance and care to acutely ill newborn infants.Respiratory Tract DiseasesEuropeProtein C: A vitamin-K dependent zymogen present in the blood, which, upon activation by thrombin and thrombomodulin exerts anticoagulant properties by inactivating factors Va and VIIIa at the rate-limiting steps of thrombin formation.Cytokines: Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.Great BritainOutcome Assessment (Health Care): Research aimed at assessing the quality and effectiveness of health care as measured by the attainment of a specified end result or outcome. Measures include parameters such as improved health, lowered morbidity or mortality, and improvement of abnormal states (such as elevated blood pressure).Infant, Premature, DiseasesPuerperal Infection: An infection occurring in PUERPERIUM, the period of 6-8 weeks after giving birth.Case-Control Studies: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.BrazilItalyPatient Admission: The process of accepting patients. The concept includes patients accepted for medical and nursing care in a hospital or other health care institution.Fluid Therapy: Therapy whose basic objective is to restore the volume and composition of the body fluids to normal with respect to WATER-ELECTROLYTE BALANCE. Fluids may be administered intravenously, orally, by intermittent gavage, or by HYPODERMOCLYSIS.Seasons: Divisions of the year according to some regularly recurrent phenomena usually astronomical or climatic. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Risk Adjustment: The use of severity-of-illness measures, such as age, to estimate the risk (measurable or predictable chance of loss, injury or death) to which a patient is subject before receiving some health care intervention. This adjustment allows comparison of performance and quality across organizations, practitioners, and communities. (from JCAHO, Lexikon, 1994)Resuscitation: The restoration to life or consciousness of one apparently dead. (Dorland, 27th ed)Shock: A pathological condition manifested by failure to perfuse or oxygenate vital organs.DenmarkRespiratory Distress Syndrome, Adult: A syndrome characterized by progressive life-threatening RESPIRATORY INSUFFICIENCY in the absence of known LUNG DISEASES, usually following a systemic insult such as surgery or major TRAUMA.Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)Models, Statistical: Statistical formulations or analyses which, when applied to data and found to fit the data, are then used to verify the assumptions and parameters used in the analysis. Examples of statistical models are the linear model, binomial model, polynomial model, two-parameter model, etc.Social Class: A stratum of people with similar position and prestige; includes social stratification. Social class is measured by criteria such as education, occupation, and income.Databases, Factual: Extensive collections, reputedly complete, of facts and data garnered from material of a specialized subject area and made available for analysis and application. The collection can be automated by various contemporary methods for retrieval. The concept should be differentiated from DATABASES, BIBLIOGRAPHIC which is restricted to collections of bibliographic references.Respiration, Artificial: Any method of artificial breathing that employs mechanical or non-mechanical means to force the air into and out of the lungs. Artificial respiration or ventilation is used in individuals who have stopped breathing or have RESPIRATORY INSUFFICIENCY to increase their intake of oxygen (O2) and excretion of carbon dioxide (CO2).Infant, Premature: A human infant born before 37 weeks of GESTATION.ROC Curve: A graphic means for assessing the ability of a screening test to discriminate between healthy and diseased persons; may also be used in other studies, e.g., distinguishing stimuli responses as to a faint stimuli or nonstimuli.Wounds and Injuries: Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural continuity.Interleukin-6: A cytokine that stimulates the growth and differentiation of B-LYMPHOCYTES and is also a growth factor for HYBRIDOMAS and plasmacytomas. It is produced by many different cells including T-LYMPHOCYTES; MONOCYTES; and FIBROBLASTS.FinlandEndotoxins: Toxins closely associated with the living cytoplasm or cell wall of certain microorganisms, which do not readily diffuse into the culture medium, but are released upon lysis of the cells.Tumor Necrosis Factor-alpha: Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.Netherlands: Country located in EUROPE. It is bordered by the NORTH SEA, BELGIUM, and GERMANY. Constituent areas are Aruba, Curacao, Sint Maarten, formerly included in the NETHERLANDS ANTILLES.Lung: Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.Cerebrovascular Disorders: A spectrum of pathological conditions of impaired blood flow in the brain. They can involve vessels (ARTERIES or VEINS) in the CEREBRUM, the CEREBELLUM, and the BRAIN STEM. Major categories include INTRACRANIAL ARTERIOVENOUS MALFORMATIONS; BRAIN ISCHEMIA; CEREBRAL HEMORRHAGE; and others.Diabetes Mellitus: A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.HMGB1 Protein: A 24-kDa HMGB protein that binds to and distorts the minor grove of DNA.Streptococcal Infections: Infections with bacteria of the genus STREPTOCOCCUS.Surgical Procedures, Operative: Operations carried out for the correction of deformities and defects, repair of injuries, and diagnosis and cure of certain diseases. (Taber, 18th ed.)Cross Infection: Any infection which a patient contracts in a health-care institution.Heart Diseases: Pathological conditions involving the HEART including its structural and functional abnormalities.AccidentsFetal Death: Death of the developing young in utero. BIRTH of a dead FETUS is STILLBIRTH.Pneumonia, Bacterial: Inflammation of the lung parenchyma that is caused by bacterial infections.France: A country in western Europe bordered by the Atlantic Ocean, the English Channel, the Mediterranean Sea, and the countries of Belgium, Germany, Italy, Spain, Switzerland, the principalities of Andorra and Monaco, and by the duchy of Luxembourg. Its capital is Paris.Staphylococcal Infections: Infections with bacteria of the genus STAPHYLOCOCCUS.Recurrence: The return of a sign, symptom, or disease after a remission.Chemical Industry: The aggregate enterprise of manufacturing and technically producing chemicals. (From Random House Unabridged Dictionary, 2d ed)Acute Lung Injury: A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).Coronary Artery Bypass: Surgical therapy of ischemic coronary artery disease achieved by grafting a section of saphenous vein, internal mammary artery, or other substitute between the aorta and the obstructed coronary artery distal to the obstructive lesion.Disseminated Intravascular Coagulation: A disorder characterized by procoagulant substances entering the general circulation causing a systemic thrombotic process. The activation of the clotting mechanism may arise from any of a number of disorders. A majority of the patients manifest skin lesions, sometimes leading to PURPURA FULMINANS.Air Pollution: The presence of contaminants or pollutant substances in the air (AIR POLLUTANTS) that interfere with human health or welfare, or produce other harmful environmental effects. The substances may include GASES; PARTICULATE MATTER; or volatile ORGANIC CHEMICALS.Life Tables: Summarizing techniques used to describe the pattern of mortality and survival in populations. These methods can be applied to the study not only of death, but also of any defined endpoint such as the onset of disease or the occurrence of disease complications.Surgical Procedures, Elective: Surgery which could be postponed or not done at all without danger to the patient. Elective surgery includes procedures to correct non-life-threatening medical problems as well as to alleviate conditions causing psychological stress or other potential risk to patients, e.g., cosmetic or contraceptive surgery.Urban Health: The status of health in urban populations.C-Reactive Protein: A plasma protein that circulates in increased amounts during inflammation and after tissue damage.Hemorrhage: Bleeding or escape of blood from a vessel.Censuses: Enumerations of populations usually recording identities of all persons in every place of residence with age or date of birth, sex, occupation, national origin, language, marital status, income, relation to head of household, information on the dwelling place, education, literacy, health-related data (e.g., permanent disability), etc. The census or "numbering of the people" is mentioned several times in the Old Testament. Among the Romans, censuses were intimately connected with the enumeration of troops before and after battle and probably a military necessity. (From Last, A Dictionary of Epidemiology, 3d ed; Garrison, An Introduction to the History of Medicine, 4th ed, p66, p119)Kidney Diseases: Pathological processes of the KIDNEY or its component tissues.Streptococcus agalactiae: A bacterium which causes mastitis in cattle and occasionally in man.Lung Diseases: Pathological processes involving any part of the LUNG.Aortic Aneurysm, Abdominal: An abnormal balloon- or sac-like dilatation in the wall of the ABDOMINAL AORTA which gives rise to the visceral, the parietal, and the terminal (iliac) branches below the aortic hiatus at the diaphragm.Demography: Statistical interpretation and description of a population with reference to distribution, composition, or structure.Neutrophils: Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.Hospitals: Institutions with an organized medical staff which provide medical care to patients.Reoperation: A repeat operation for the same condition in the same patient due to disease progression or recurrence, or as followup to failed previous surgery.Health Status Disparities: Variation in rates of disease occurrence and disabilities between population groups defined by socioeconomic characteristics such as age, ethnicity, economic resources, or gender and populations identified geographically or similar measures.Vascular Surgical Procedures: Operative procedures for the treatment of vascular disorders.African Continental Ancestry Group: Individuals whose ancestral origins are in the continent of Africa.ScotlandRural Population: The inhabitants of rural areas or of small towns classified as rural.Occupational Exposure: The exposure to potentially harmful chemical, physical, or biological agents that occurs as a result of one's occupation.GermanyEscherichia coli Infections: Infections with bacteria of the species ESCHERICHIA COLI.CaliforniaChina: A country spanning from central Asia to the Pacific Ocean.Forecasting: The prediction or projection of the nature of future problems or existing conditions based upon the extrapolation or interpretation of existing scientific data or by the application of scientific methodology.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Confounding Factors (Epidemiology): Factors that can cause or prevent the outcome of interest, are not intermediate variables, and are not associated with the factor(s) under investigation. They give rise to situations in which the effects of two processes are not separated, or the contribution of causal factors cannot be separated, or the measure of the effect of exposure or risk is distorted because of its association with other factors influencing the outcome of the study.Canada: The largest country in North America, comprising 10 provinces and three territories. Its capital is Ottawa.Infant, Very Low Birth Weight: An infant whose weight at birth is less than 1500 grams (3.3 lbs), regardless of gestational age.Cardiac Surgical Procedures: Surgery performed on the heart.Longevity: The normal length of time of an organism's life.TaiwanIndiaSuicide: The act of killing oneself.Guinea-Bissau: A republic in western Africa, south of SENEGAL and west of GUINEA. Its capital is Bissau.Mice, Knockout: Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.Blood Pressure: PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.Educational Status: Educational attainment or level of education of individuals.Residence Characteristics: Elements of residence that characterize a population. They are applicable in determining need for and utilization of health services.Lung Neoplasms: Tumors or cancer of the LUNG.Health Surveys: A systematic collection of factual data pertaining to health and disease in a human population within a given geographic area.Health Status Indicators: The measurement of the health status for a given population using a variety of indices, including morbidity, mortality, and available health resources.Body Mass Index: An indicator of body density as determined by the relationship of BODY WEIGHT to BODY HEIGHT. BMI=weight (kg)/height squared (m2). BMI correlates with body fat (ADIPOSE TISSUE). Their relationship varies with age and gender. For adults, BMI falls into these categories: below 18.5 (underweight); 18.5-24.9 (normal); 25.0-29.9 (overweight); 30.0 and above (obese). (National Center for Health Statistics, Centers for Disease Control and Prevention)Air Pollutants: Any substance in the air which could, if present in high enough concentration, harm humans, animals, vegetation or material. Substances include GASES; PARTICULATE MATTER; and volatile ORGANIC CHEMICALS.Vital Statistics: Used for general articles concerning statistics of births, deaths, marriages, etc.Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).Analysis of Variance: A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.Gestational Age: The age of the conceptus, beginning from the time of FERTILIZATION. In clinical obstetrics, the gestational age is often estimated as the time from the last day of the last MENSTRUATION which is about 2 weeks before OVULATION and fertilization.Surgical Wound Infection: Infection occurring at the site of a surgical incision.Trauma Severity Indices: Systems for assessing, classifying, and coding injuries. These systems are used in medical records, surveillance systems, and state and national registries to aid in the collection and reporting of trauma.
Overwhelming post-splenectomy infection
Schwartz PE, Sterioff S, Mucha P, Melton LJ, Offord KP (November 1982). "Postsplenectomy sepsis and mortality in adults". ... An overwhelming post-splenectomy infection (OPSI) or Overwhelming post-splenectomy sepsis (OPSS) is a rare but rapidly fatal ... OPSI is almost always fatal without treatment, and modern treatment has decreased the mortality to approximately 40-70 percent ... The infections are typically characterized by either meningitis or sepsis, and are caused by encapsulated organisms including ...
Heart rate variability
HRV is decreased in patients with sepsis. Loss of HRV has both diagnostic and prognostic value in neonates with sepsis. The ... Reduced HRV has been shown to be a predictor of mortality after myocardial infarction although others have shown that the ... Griffin, MP; Moorman, JR (January 2001). "Toward the early diagnosis of neonatal sepsis and sepsis-like illness using novel ... Decreased HRV in patients with cirrhosis has a prognostic value and predicts mortality. Loss of HRV is also associated with ...
Sri Siddhartha Medical College
Healthcare in Russia
Countries such as Spain, have shown a rise in mortality risk, due to a large elderly population there. However, there are tools ... Bouza C, López-Cuadrado T, Saz-Parkinson Z, Blanco J (2014). "Epidemiology and recent trends of severe sepsis in Spain: a ... Multiple organ failure can be associated with sepsis and is often fatal. ...
Methicillin-resistant Staphylococcus aureus
... mortality rate. MRSA sepsis that occurs within one year following a surgical infection has a mortality rate of around 55%. ... Bacterial sepsis occurs with most (75%) of cases of invasive MRSA infection. In 2009, there were an estimated 463,017 ... Surgical site infections (SSI) occur on the skin surface but can spread to internal organs and blood to cause sepsis. ... It has been argued that the observed increased mortality among MRSA-infected people may be the result of the increased ...
... hydroxyethyl starch 130/0.4 with balanced crystalloid solution on mortality and kidney failure in patients with severe sepsis ( ... The Surviving Sepsis Campaign decided to ban HES from treatment in sepsis patients. On June 14, 2013, PRAC, which is the safety ... "Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock: 2012". Critical Care ... The study was performed in patients that were less sick than in 6s; however, the increase in mortality was similar to 6s. There ...
... does not improve mortality in severe sepsis or septic shock but does increase bleeding risks. Therefore, a ... Drotrecogin alfa has not been found to improve outcomes in people with severe sepsis. The manufacturer's aggressive strategies ... withdrew Xigris from the market after a major study showed no efficacy for the treatment of sepsis. ... except for acute coagulopathy related to sepsis Chronic severe hepatic disease HIV infection in association with a last known ...
Acute liver failure
... substantially increases risk of sepsis. Bacterial sepsis mostly due to gram positive organisms and fungal sepsis are observed ... Historically mortality has been high, being in excess of 80%. In recent years the advent of liver transplantation and ... Severe lung injury and hypoxemia result in high mortality. Most cases of severe lung injury are due to ARDS, with or without ... sepsis, cardiac arrhythmia or arrest and respiratory failure. The median time to death after admission was 5 days. Intravenous ...
Molecular epidemiology was successful in tracing 13 cases of sepsis in neonates to a single clone of SHN during a two-year ... SHN infections were high in morbidity, but had a low rate of mortality. More undocumented instances of SHN infections may not ... novobiosepticus Strain causing Sepsis in a Neonatal Intensive Care Unit.Abstract Journal of Clinical Microbiology, 43, 4877- ... Thirteen of these cases were confirmed as sepsis in neonates resulting from SHN infection. These were the first clinical ...
There is an increased risk of mortality and length of stay in the intensive-care unit in these patients. In severe ... Troponins are increased in around 40% of patients with critical illnesses such as sepsis. ... Zethelius B, Johnston N, Venge P (February 2006). "Troponin I as a predictor of coronary heart disease and mortality in 70-year ... Henry CR, Satran D, Lindgren B, Adkinson C, Nicholson CI, Henry TD (January 2006). "Myocardial injury and long-term mortality ...
... levels have long been noted to predict mortality in patients with sepsis. Because of this, and its pleiotropic ... In October 2011 Xigris was withdrawn from the market by Eli Lilly due to a higher mortality in a trial among adults. Protein ... In October 2011 rhAPC (Xigris®) was withdrawn from the market by Eli Lilly due to a higher mortality in a trial among adults. ... Beginning with the PROWESS clinical trial of 2001, it was recognised that many of the symptoms of sepsis may be ameliorated by ...
The mortality rate from sepsis is approximately 40% in adults and 25% in children. It is significantly greater when sepsis is ... In rough order of increasing severity these are, bacteremia or fungemia; sepsis, severe sepsis or sepsis syndrome; septic shock ... Sepsis has a worldwide incidence of more than 20 million cases a year, with mortality due to septic shock reaching up to 50 ... Levinson, A.T.; Casserly, B.P.; Levy, M.M. (April 2011). "Reducing mortality in severe sepsis and septic shock". Seminars in ...
"Neurotensin increases mortality and mast cells reduce neurotensin levels in a mouse model of sepsis". Nature Medicine. 14 (4): ... Neurolysin has also been implicated in pain control, blood pressure regulation, sepsis, reproduction, cancer biology ... Neurolysin has also been implicated in pain control, blood pressure regulation, sepsis, reproduction, cancer biology, ...
Mir-193 microRNA precursor family
... sepsis, haematological malignancies, sepsis, and ventilated patients. Human Neutrophil Antigen (HNA) has been associated with ... Mortality rate is high, with 89.7% of the patients died after 24 days. Immunosuppressive treatment is the most common way of ... It occurs in 15% of the transfused patient with mortality rate of 5 to 10%. Recipient risk factors includes: end-stage liver ...
Detrick, MD in the last 1980s which has shown to be safe, well tolerated and effective in reducing mortality and morbidity due ... petechia and occasionally sepsis. The symptoms of the disease can be confusing; the condition can be mistaken for a different ... neurological and immune systems and has a mortality rate between 20 and 30%. Symptoms of the disease are conjunctivitis, ...
The immune response to the bacteria can cause sepsis and septic shock, which has a high mortality rate. Bacteria can also ... This is because there are high mortality rates from progression to sepsis if antibiotics are delayed. The treatment of ... "The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)". JAMA. 315 (8): 801-810. doi:10.1001/jama ... It is distinct from sepsis, which is the host response to the bacteria. Bacteria can enter the bloodstream as a severe ...
In a trial, it was found to decrease the mortality of Gram-negative bacterial-induced sepsis. Studies suggest that its binding ... in baboon sepsis is related to its antibacterial, not antiendotoxin, properties". Annals of Surgery. US: Lippincott Williams & ... as adjunctive treatment for children with severe meningococcal sepsis: a randomised trial". Lancet. England: Lancet Publishing ...
Mortality decreases with age until late adulthood, with the elderly at risk for CAP and its associated mortality. More CAP ... Patients with sepsis require intensive care, with blood-pressure monitoring and support against hypotension. Sepsis can cause ... Major complications of CAP include: Sepsis, when microorganisms enter the bloodstream and the immune system responds. Sepsis ... Factors increasing mortality are identical to those indicating hospitalization. Unresponsive CAP may be due to a complication, ...
Rondon, E.; Venkataraman, R. (2005). "Afelimomab led to a modest mortality benefit in patients with severe sepsis and elevated ... Administration of afelimomab reduces the concentration of interleukin-6 in patients with sepsis, but reduces mortality only ... a Randomized Controlled Sepsis Study Investigators (2004). "Efficacy and safety of the monoclonal anti-tumor necrosis factor ... antibody F(ab')2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levels". Critical Care Medicine ...
The mortality rate is 4.3%. Jugular vein thrombosis is a condition that may occur due to infection, intravenous drug use or ... Jugular vein thrombosis can have a varying list of complications, including: systemic sepsis, pulmonary embolism, and ... which stratifies risk of mortality due to pulmonary embolism in patients with cancer, who typically have higher rates of ...
Non-specific effect of vaccines
... are less likely to develop sepsis and exhibit an overall reduction in child mortality of around 50%. In a recent WHO- ... "estimated effects are in the region of a halving of mortality risk" and "any effect of BCG vaccine on all-cause mortality is ... BCG protected against sepsis as well as respiratory infections. Among BCG vaccinated children, those who develop a BCG scar or ... However it should be noted that no randomized trials testing the effect of smallpox vaccine on overall mortality and morbidity ...
Mortality increases during cancer treatments if neutropenia is also present. Congenital neutropenia is determined by blood ... Sometimes overlooked is the presence of hypothermia, which can be present in sepsis. Physical examination and accessing the ... Congenital neutropenia is related to alloimmunization, sepsis, maternal hypertension, twin-to-twin transfusion syndrome, and Rh ... These are: Bacterial or fungal sepsis Necrotizing enterocolitis, circulating neutrophil population depleted ...
"Morbidity and Mortality Weekly Report. 44 (19): 381-2. PMID 7739512. Archived from the original on 25 June 2017.. ... sepsis, borreliosis, EHEC enteritis, leptospirosis, scrub typhus, plague, Q fever, candidiasis, histoplasmosis, trypanosomiasis ... 25-90% mortality. The virus spreads through direct contact with body fluids, such as blood from infected humans or other ... Ebola has a high mortality rate among primates. Frequent outbreaks of Ebola may have resulted in the deaths of 5,000 ...
HIV-related mortality (affected by the recent introduction of antiretrovirals) accounted for 20% of the effect. Mortality ... sepsis; congestive heart failure; chronic obstructive pulmonary disease; and complications of devices, implants and grafts. ... A 2018 study in the Journal of Political Economy found that upon its introduction, Medicaid reduced infant and child mortality ... A 2018 study in the American Journal of Public Health found that the infant mortality rate declined in states that had Medicaid ...
Hematopoietic stem cell transplantation
Mortality for allogeneic stem cell transplantation can be estimated using the prediction model created by Sorror et al., ... This puts a patient at high risk of infections, sepsis and septic shock, despite prophylactic antibiotics. However, antiviral ... HSCT is associated with a high treatment-related mortality in the recipient (38 percent or higher), which limits its use to ... However, for other cancers such as acute myeloid leukemia, the reduced mortality of the autogenous relative to allogeneic HSCT ...
Surviving Sepsis Campaign
Mortality associated with severe sepsis remains high at 30-50%. When shock is present, mortality is reported to be even higher ... Sepsis. Severe sepsis. Septic shock. Multiple organ dysfunction syndrome. Other shock. Cardiogenic shock. Distributive shock. ... The Surviving Sepsis Campaign (SSC) is a global initiative to bring together professional organizations in reducing mortality ... "Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016". Intensive Care Medicine. ...
History of England
Urinary tract infection
a b Jorge Gutierrez-Aceves, "Preoperative Antibiotics and Prevention of Sepsis in Genitourinary Surgery" in Smith's Textbook of ... GBD 2015 Mortality and Causes of Death, Collaborators. (8 October 2016). "Global, regional, and national life expectancy, all- ... cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden ... Urine may contain pus (a condition known as pyuria) as seen from a person with sepsis due to a urinary tract infection. ...
Despite a significant mortality risk, long-term prognosis for infants undergoing NEC surgery is improving, with survival rates ... Sepsis, anal fissure, infectious enterocolitis, Hirschsprung disease. Prevention. Breast milk, probiotics.. ... "prevents severe NEC as well as all-cause mortality in preterm infants." ...
Morbidity and Mortality Weekly Report. 55 (2): 44-46. PMID 16424859. Archived (PDF) from the original on 29 June 2011.. ... Sometimes, influenza may have abnormal presentations, like confusion in the elderly and a sepsis-like syndrome in the young.[34 ... "Mortality due to influenza in the United States-an annualized regression approach using multiple-cause mortality data". ... Although mortality is usually low, the virus can produce weight loss and poor growth, causing economic loss to farmers. ...
Mortality of meningitis-related infections is much lower than mortality associated with septicemia. Because C. canimorsus ... To control DIC, a condition often associated with sepsis, plasmaphoresis (separation and removal of blood plasma from blood ... The mortality rate in individuals with asplenia is much higher than any other at risk-category for C. canimorsus infections. ...
Individuals with Addison's disease have more than a doubled mortality rate. Furthermore, individuals with Addison's disease ... sepsis, and bleeding into both adrenal glands. Secondary adrenal insufficiency is caused by not enough ... Bergthorsdottir, Ragnhildur; Leonsson-Zachrisson, Maria; Odén, Anders; Johannsson, Gudmundur (2006-12-01). "Premature Mortality ... and diabetes mellitus have an almost 4 time increase in mortality compared to individuals with only diabetes. ...
Gugur kandungan bahasa Indonesia, ensiklopedia bebas
Sepsis dapat terjadi akibat penggunaan alat yang tidak steril atau kuman berasal dari vagina dan kulit. Bahaya yang lebih ... Unsafe Abortion: Global and Regional Estimates of Incidence of and Mortality due to Unsafe Abortion with a Listing of Available ... Raymond, EG; Grossman, D; Weaver, MA; Toti, S; Winikoff, B (November 2014). "Mortality of induced abortion, other outpatient ...
سرطان پروستات - ویکیپدیا، دانشنامهٔ آزاد
Antibiotics should be used to prevent complications like fever, urinary tract infections, and sepsis. Fifty-five percent of ... Hsing AW, Tsao L, Devesa SS (January 2000). "International trends and patterns of prostate cancer incidence and mortality". Int ... Dec 15, 2012). "Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic ... Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ (April 2003). "Overweight, obesity, and mortality from cancer in a ...
... sepsis, and respiratory failure to the mortality independently of the stress ulceration cannot be ignored. Risk factors for ... People with stress ulcers have a longer ICU length of stay (up to 8 days) and a higher mortality (up to 4 fold) than patients ... While the bleeding and transfusions associated with the stress ulcerations contribute to the increased mortality, the ... Dec 2001). "The attributable mortality and length of intensive care unit stay of clinically important gastrointestinal bleeding ...
... with ensuing high mortality rates. The clinical presentation is dominated by severe sepsis and the formation of microabscesses ... Furthermore, it has been implicated in neonatal mortality among puppies. Recently, SDSD has been described as an emerging ... "Neonatal mortality in puppies due to bacteremia by Streptococcus dysgalactiae subsp. dysgalactiae". Journal of Clinical ...
Sepsis also increases the risk of developing new-onset atrial fibrillation. Disorders of breathing during sleep, such ... GBD 2013 Mortality and Causes of Death, Collaborators (17 December 2014). "Global, regional, and national age-sex specific all- ... GBD 2015 Mortality and Causes of Death, Collaborators. (8 October 2016). "Global, regional, and national life expectancy, all- ... cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden ...
Intensive care medicine
... higher ICU volume was significantly associated with lower ICU and hospital mortality rates. For example, adjusted ICU mortality ... including sepsis status), renal (and metabolic), and respiratory system. ... In this fashion, mortality declined from 90% to around 25%. Patients were managed in three special 35-bed areas, which aided ... Because of the lack of critical care and the high rate of infection, there was a high mortality rate of hospitalised soldiers, ...
敗血症 - 维基百科，自由的百科全书
The mortality rate was 90% prior to antibiotic therapy, but is now generally quoted as 15% once this illness is correctly ... Sepsis following a throat infection was described by Schottmuller in 1918. However, it was André Lemierre, in 1936, who ... Sepsis following from a throat infection was described by Scottmuller in 1918. However, it was Andre Lemierre, in 1936, who ... When properly diagnosed, the mortality of Lemierre's syndrome is about 4.6%. Since this disease is not well known and often ...
Variolation had a 0.5-2 percent mortality rate, considerably less than the 20-30 percent mortality rate of the disease. Two ... and fulminating sepsis. ... The technique did have a 0.5-2.0% mortality rate, but that was ... By the 16th century, smallpox had become entrenched across most of Europe, where it had a mortality rate as high as 30 ... By the 16th century smallpox had become a predominant cause of morbidity and mortality throughout much of the world. ...
... sepsis, and anthrax. It is given by injection into a vein. ... intravenous administration is associated with lower mortality ... "Prolonged versus short-term intravenous infusion of antipseudomonal β-lactams for patients with sepsis: a systematic review and ... "Meropenem dosing in critically ill patients with sepsis receiving high-volume continuous venovenous hemofiltration" (PDF) ...
Mortality related to sepsis increases with age, from less than 10% in the age group of 3 to 5 years to 60% by sixth decade of ... Severe sepsis is defined as sepsis with sepsis-induced organ dysfunction or tissue hypoperfusion (manifesting as hypotension, ... According to SIRS, there were different levels of sepsis: sepsis, severe sepsis, and septic shock. The definition of SIRS ... MedlinePlus Encyclopedia: Sepsis. Retrieved 29 November 2014. *^ a b c d Munford RS, Suffredini AF (2014). "Ch. 75: Sepsis, ...
Worldwide mortality due to infectious diseases Rank. Cause of death. Deaths 2002. (in millions). Percentage of. all ... and staphylococcus releases toxins that produce shock and sepsis. Not all infectious agents cause disease in all hosts. For ... GBD 2013 Mortality and Causes of Death, Collaborators (17 December 2014). "Global, regional, and national age-sex specific all- ... The first European influenza epidemic occurred between 1556 and 1560, with an estimated mortality rate of 20%. ...
Moore, Sandra D. (1987). "Male-Biased Mortality in the Butterfly Euphydryas editha: a Novel Cost of Mate Acquisition". The ... Another example of this is Sepsis cynipsea, where males of the species mount females to guard them from other males and remain ... female reluctance to mate and sexual selection on body size in the dung fly Sepsis cynipsea". Ethology. 106 (7): 577-593. doi: ...
"Global, regional, national, and selected subnational levels of stillbirths, neonatal, infant, and under-5 mortality, 1980-2015 ... neonatal or perinatal mortality). Therefore, data from these institutions on (still)births can not simply be compared one-on- ... The birth and mortality numbers from the CBS include all liveborn children, regardless of gestational duration and all ... Neonatal sepsis *Group B streptococcal infection. *Neonatal conjunctivitis. Other. *Miscarriage. *Perinatal mortality * ...
Late mortality after sepsis | The BMJ
They identified an additional burden of mortality associated with sepsis that persists into longer term recovery for up to at ... Late mortality after sepsis: propensity matched cohort study. BMJ2016;353:i2375. ... report that patients who survive an episode of sepsis have a significant excess risk of mortality for a prolonged period of ... Late mortality after sepsis. BMJ 2016; 353 doi: https://doi.org/10.1136/bmj.i2735 (Published 17 May 2016) Cite this as: BMJ ...
Prompt UTI Antibiotics Cut Mortality, Sepsis Risk
Cite this: Prompt UTI Antibiotics Cut Mortality, Sepsis Risk in Older Adults - Medscape - Mar 01, 2019. ... These mortality rates were 5.4%, 2.8%, and 1.6%, respectively (P , .001).. The researchers also found a small but significant ... All-cause mortality within 60 days of index UTI diagnosis was 2.18 times higher for the no-antibiotic group and 1.16 times ... Hay notes that the increased risk for sepsis in the no-antibiotic or deferred-antibiotic group might not be a direct result of ...
Late mortality after sepsis: propensity matched cohort study | The BMJ
... in late mortality. The higher mortality in the sepsis cohort persisted for a year (adjusted 181 day-one year mortality was 11.6 ... in late mortality. The higher mortality in the sepsis cohort persisted for at least 180 days. Among patients with sepsis who ... More than one in five patients who survives sepsis experiences a late death related to sepsis. The degree of late mortality ... 1 2 While mortality in hospital is falling,2 3 4 5 longer term mortality after sepsis has remained high as many patients die in ...
Sepsis Mortality Higher in Mid-Atlantic States | Medpage Today
... where infection and sepsis death rates were significantly higher than in surrounding areas, researchers reported. ... Of the 1 million to 3.5 million cases of infection and sepsis each year, Gaieski said, mortality ranges from 33% to 14%. The ... "Infection-related deaths are a leading cause of morbidity and mortality in the U.S., affecting over 1 million people a year, ... Researchers have mapped out two "hot spots" in the U.S., where deaths from infection and sepsis were significantly higher than ...
ASN: Statins Linked to Lower Mortality in Sepsis | Medpage Today
Statin therapy improves the survival odds in critically ill patients with sepsis, but does not reduce the risk of acute kidney ... Sepsis accompanied by acute kidney injury is associated with a 70% mortality, compared with 45% for sepsis alone. Cellular ... "To our knowledge, this study is the first to report on the effects of statins on the incidence of sepsis-related acute kidney ... DENVER -- Statin therapy improves the survival odds in critically ill patients with sepsis, but does not reduce the risk of ...
JCI - Sepsis-induced immune dysfunction: can immune therapies reduce mortality?
... early sepsis mortality has diminished, only to surge later after "recovery" from acute events, prompting a search for sepsis- ... Sepsis is a systemic inflammatory response induced by an infection, leading to organ dysfunction and mortality. Historically, ... Sepsis is well known to alter innate and adaptive immune responses for sustained periods after clinical "recovery," with ... and reversing the persistent immune cell dysfunction that is associated with mortality long after the acute events of sepsis ...
Vitamin C, B1 and Hydrocortisone Can Reduce Mortality From Sepsis
Sepsis is a progressive disease process caused by an aggressive, out-of-control immune response to an infection in the ... Sepsis is a progressive disease process caused by an aggressive, out-of-control immune response to an infection in the ... Research has also shown many patients with sepsis are vitamin deficient, and when thiamine is given, it reduces mortality. ... Other research has also shown thiamine reduces mortality from sepsis and helps protect against renal failure, which is why ...
Role of NFkappaB in the mortality of sepsis
Study Says Resiniferatoxin May Increase Sepsis-related Mortality
New Sepsis Discovery may Help Prevent Heart Failure. Researchers from University of Michigan have found in sepsis patients, the ... Research Find Death Switch in Sepsis also Promotes Survival. A protein that plays a dual role in the liver during sepsis has ... Study Finds Newborns Still at Risk for Sepsis Due to Streptococci and E. Coli. Newborns with bloodstream infections can suffer ... Roundworm To Combat Sepsis. A protein that occurs naturally in a type of roundworm can be used to combat systemic inflammation ...
Liver molecule Ashwell receptor reduces mortality during sepsis | TopNews
Home » Liver molecule Ashwell receptor reduces mortality during sepsis. Liver molecule Ashwell receptor reduces mortality ... The researchers made use of a mouse model of sepsis, and found that the pneumococcal sialidase also removes sialic acid from ... Also, it was found that the death in patients with sepsis is mainly caused by a condition called disseminated intravascular ... "This finding contradicts the prevailing notion that the low platelet count of sepsis is due to the consumption of coagulation ...
Sepsis cost, mortality higher in teaching hospitals
... provided care for children with sepsis at a greater cost without improving mortality rates. Researchers noted that US teaching ... Pediatric patients treated for sepsis at non-teaching hospitals had a mortality rate of 1.63% compared with 4.66% in teaching ... 2,034 in teaching hospitals - they found that patients admitted to non-teaching hospitals for sepsis had a mortality rate of ... Pediatric patients treated for sepsis at non-teaching hospitals had a mortality rate of 1.63% compared with 4.66% in teaching ...
Inflammatory markers at hospital discharge predict subsequent mortality after pneumonia and sepsis. - PubMed - NCBI
Inflammatory markers at hospital discharge predict subsequent mortality after pneumonia and sepsis.. Yende S1, DAngelo G, ... Inflammatory Markers at Hospital Discharge Predict Subsequent Mortality after Pneumonia and Sepsis ... Inflammatory Markers at Hospital Discharge Predict Subsequent Mortality after Pneumonia and Sepsis ... Inflammatory Markers at Hospital Discharge Predict Subsequent Mortality after Pneumonia and Sepsis ...
Ultraviolet air sterilizer reduces sepsis and mortality in cardiac surgery patients | EurekAlert! Science News
An ultraviolet air sterilizer reduces sepsis and mortality in cardiac surgery patients, according to research presented today ... We found lower rates of sepsis and mortality in patients who recovered from cardiac surgery in an ICU fitted with an ... Ultraviolet air sterilizer reduces sepsis and mortality in cardiac surgery patients. European Society of Cardiology ... Lisbon, Portugal - 16 October 2016: An ultraviolet air steriliser reduces sepsis and mortality in cardiac surgery patients, ...
Varying Estimates of Sepsis Mortality Using Death Certificates and Administrative Codes - United States, 1999-2014 | MMWR
CDC report looks at differences between sepsis-related mortality estimates reported using death certificates and administrative ... CDC report looks at differences between sepsis-related mortality estimates reported using death certificates and administrative ... estimates of sepsis-related mortality based on death certificates using the CDC WONDER database with published sepsis mortality ... compared national estimates of sepsis-related mortality based on death certificates with previously published sepsis mortality ...
Methods for Reducing Sepsis Mortality in Emergency Departments and Inpatient Units
Severe Sepsis Bundles The Severe Sepsis Bundles include the Severe Sepsis 3-Hour Rescuscitation Bundle and the 6-Hour Septic ... Home / Resources / Publications / Methods for Reducing Sepsis Mortality in Emergency Departments and Inpatient Units ... Methods for reducing sepsis mortality in emergency departments and inpatient units. Joint Commission Journal on Quality and ... The health system reduced overall sepsis mortality by approximately 50 percent in a six-year period (2008-2013; sustained ...
Hospital leans on machine learning to reduce sepsis-related mortality rate | Healthcare IT News
Cabell Huntington Hospital also diminished the average sepsis-related hospital length of stay with machine learning-generated ... This time factor is important since early antibiotic administration is key to reducing sepsis mortality. ... sepsis-related in-hospital mortality rate was 33.5 percent lower during the post-implementation period and the average sepsis- ... Machine learning also has allowed for improved predictive power in sepsis detection by warning Cabell clinicians of sepsis ...
Reducing Sepsis Mortality
The Centers Sepsis Project aims to reduce sepsis mortality. ... Sepsis is the leading cause of death in hospitals with a ... mortality rate between 25-50% and $17 billion in annual costs. ... Reducing Sepsis Mortality. Sepsis is the bodys life- ... Sepsis Mortality. At the Joint Commission Center for Transforming Healthcare, we know that sepsis mortality can be reduced, ... The following additional resources are available for the Reducing Sepsis Mortality project:. *Reducing Sepsis Mortality Fact ...
Long-term mortality and quality of life in sepsis: a systematic review
The use of 28-day mortality as an end point for clinical studies may lead to inaccurate inferences. Both observational and ... Patients with sepsis have ongoing mortality beyond short-term end points, and survivors consistently demonstrate impaired ... Long-term mortality and quality of life in sepsis: a systematic review Crit Care Med. 2010 May;38(5):1276-83. doi: 10.1097/CCM. ... Patients with sepsis showed ongoing mortality up to 2 yrs and beyond after the standard 28-day inhospital mortality end point. ...
Neurotensin increases mortality and mast cells reduce neurotensin levels in a mouse model of sepsis. - PubMed - NCBI
Neurotensin increases mortality and mast cells reduce neurotensin levels in a mouse model of sepsis.. Piliponsky AM1, Chen CC, ... These findings show that NT contributes to sepsis-related mortality in mice during severe CLP and that mast cells can lower NT ... Neurotensin increases mortality and mast cells reduce neurotensin levels in a mouse model of sepsis ... Neurotensin increases mortality and mast cells reduce neurotensin levels in a mouse model of sepsis ...
ATS 2017 Wrap-up: Rapid sepsis treatment, predicting mortality after the ICU and more | EurekAlert! Science News
ATS 2017 Wrap-up: Rapid sepsis treatment, predicting mortality after the ICU and more The annual American Thoracic Society ... ATS 2017 Wrap-up: Rapid sepsis treatment, predicting mortality after the ICU and more. Michigan Medicine - University of ... ats-2017-wrap-up-rapid-sepsis-treatment-predicting-mortality-after-icu-and-more ... The value of rapid sepsis treatment. Published in The New England Journal of Medicine this week, the study looks at the ...
Sepsis-Related Mortality of Very Low Birth Weight Brazilian Infants: The Role of Pseudomonas aeruginosa
Table 4: Risk factors associated with sepsis-related mortality and sepsis relate survival of 71 VLBW infants with sepsis, ... Sepsis-Related Mortality. Overall 21 of the 71 VLBW infants with sepsis (29.6%) died, being 2/10 (20%) from EOS, and 19/61 ( ... Table 2: Risk factors for sepsis-related mortality in 71 VLBW infants with sepsis, Servidores EstadoHospital, April 2001/ ... Overall 21 of 71 infants with sepsis (29.6%) died. Risk factors for sepsis-related mortality were gestational age ≤28 weeks, ...
Growth Differentiation Factor-15 Is a Predictor of Mortality in Critically Ill Patients with Sepsis
... Lukas Buendgens,1 Eray ... We measured GDF-15 levels in 219 critically ill patients (146 with sepsis, 73 without sepsis) upon admission to the intensive ... and overall mortality (HR 2.02, 95% CI 1.02-3.88) in all ICU critically ill patients as well as in a large subgroup of sepsis ... Serum concentrations of GDF-15 can predict poor survival in chronic diseases, but its role in sepsis is obscure. Therefore, we ...
Doctor accountability helps trust bring down sepsis mortality | HSJ Local | Health Service Journal
One of Englands largest teaching hospitals has achieved a dramatic turnaround in the care and survival of patients with sepsis ... Doctor accountability helps trust bring down sepsis mortality. By Shaun Lintern2015-04-10T12:10:00 ... One of Englands largest teaching hospitals has achieved a dramatic turnaround in the care and survival of patients with sepsis ...
Hospital System Reduces Sepsis Mortality by 33 Percent in Three Years
CHW launched the three-year initiative in July 2007 with the goal of reducing its inpatient severe sepsis mortality rate byÂ 5 ... Hospital System Reduces Sepsis Mortality by 33 Percent in Three Years. September 9, 2010 ... According to the national Surviving Sepsis Campaign, there are more than 750,000 cases of severe sepsis annually in North ... that its severe sepsis prevention initiative has saved an additional 991 lives and reduced severe sepsis inpatient mortality ...
In the news - Reducing sepsis mortality | Main Line Health | Philadelphia, Pennsylvania
... by integrating clinical sepsis bundles - a grouping of evidence-based measures proven to ensure best outcomes - with reliably ... MLH was able to reduce the number of deaths from severe sepsis by more than 50 percent at four acute care hospitals. ... by integrating clinical sepsis bundles - a grouping of evidence-based measures proven to ensure best outcomes - with reliably ...
Immunocompromised Patients with Sepsis May Face Higher Mortality at Hospitals Treating Small Numbers of Such Patients
Immunosuppressed patients with sepsis appear more likely to die if they are treated in a hospital caring for a relatively small ... In "Hospital Volume of Immunosuppressed Sepsis Patients and Sepsis Mortality," Jared A. Greenberg, MD, MSc, and coauthors ... Immunocompromised Patients with Sepsis May Face Higher Mortality at Hospitals Treating Small Numbers of Such Patients. ... which many studies have shown reduce sepsis mortality, according to the authors. ...
Sepsis survivors' persistent immunosuppression raises mortality risk | The Hospitalist
Inflammation and immunosuppression could persist for some patients up to a year after a hospitalization for sepsis, and these ... Inflammation and immunosuppression could persist for some patients up to a year after a hospitalization for sepsis, and these ... Yende and colleagues performed a multicenter, prospective cohort study of 483 patients who were hospitalized for sepsis at 12 ... Patients with this phenotype of hyperinflammation and immunosuppression had more than eight times the risk of 1-year mortality ...
Sepsis And Shock Response Team In The ED Reduces Mortality | Science 2.0
... formed a multidisciplinary sepsis and shock response team (SSRT) to help alert emergency department providers when these ... Results showed that the observed/expected sepsis mortality index improved from 1.38 pre-SSRT to 0.68 post-SSRT implementation. ... An automated electronic sepsis alarm for early recognition, followed by standardized multidisciplinary management of patients ... with suspected sepsis or shock with SSRT, improved the compliance with standard care measures and overall mortality. ...
Easing ICU Admission Criteria Improves Mortality in Patients with Sepsis, Reduces Costs
conducted a study of patients with sepsis admitted in the ICU and found that a significant decrease in mortality, ICU length of ... conducted a study of patients with sepsis admitted in the ICU and found that a significant decrease in mortality, ICU length of ... conducted a study of patients with sepsis admitted in the ICU and found that a significant decrease in mortality, ICU length of ... This retrospective study focused on 886 medical records from patients with sepsis and compared mortality and length of stay ...
Is Sepsis-Associated Mortality Preventable? | Clinician Reviews
Most sepsis-associated deaths in US acute care hospitals are unlikely to be preventable through better hospital-based care, a ... Is Sepsis-Associated Mortality Preventable?. JAMA Netw Open; 2019 Feb 15; Rhee, et al. Publish date:. March 5, 2019. Week ... Is Sepsis-Associated Mortality Preventable?, JAMA Netw Open; 2019 Feb 15; Rhee, et al ... Prevalence, underlying causes, and preventability of sepsis-associated mortality in US acute care hospitals. JAMA Netw Open. ...
TypicallyIndividualsMorbidity and mortaPneumoniaNeonatal sepsisLate-Onset SepsisComplicationsPolymicrobialIntensive careOnsetObstetricOrgan Failure AssessmentReduce the mortality rateInfluenzaMulticenterMurineSurviving Sepsis CMethodsPredicts mortalityRegarding in-hospital mortality2019HemorrhageAppalling mortality rateARDSInfantSurgicalPreventableHospitalRateSignificantly0.02AcuteAntibioticsLogistic regression0.01Reduction in mortalityAntimicrobialConfidence intervalChild mortalityDiagnosisTherapyRates
- The infections are typically characterized by either meningitis or sepsis, and are caused by encapsulated organisms including Streptococcus pneumoniae. (wikipedia.org)
- These surgical interventions, including resections of the colon, and the removal of the teeth, tonsils, and occasionally stomach, were widely discredited during the 1930s when it was discovered that permanent recovery did not typically occur after such interventions, and the mortality of such colon surgeries was unacceptably high. (wikipedia.org)
- An overwhelming post-splenectomy infection (OPSI) or Overwhelming post-splenectomy sepsis (OPSS) is a rare but rapidly fatal infection occurring in individuals following removal of the spleen. (wikipedia.org)
- Dr. William Hunter CB FRSE (1861-1937) was a British surgeon known primarily for his theories on oral sepsis, one of the inspirations for the Henry Cotton theory of focal sepsis which led to the increased number of tooth extractions and tonsillectomies in the 1910s and 20s (under the presumption that hidden sepsis could lead to a wider health decline in individuals). (wikipedia.org)
Morbidity and morta9
- Background: Sepsis is a leading cause of morbidity and mortality after surgery. (elsevier.com)
- Background: Maternal morbidity and mortality in sub-Saharan Africa remains high despite global efforts to reduce it. (uib.no)
- In order to lower maternal morbidity and mortality in the immediate term, reduction of delay in the provision of quality obstetric care is of prime importance. (uib.no)
- The aim of this study is to assess the occurrence of severe maternal morbidity and mortality in a rural referral hospital in Tanzania as proposed by the WHO near miss approach and to assess implementation levels of key evidence-based interventions in women experiencing severe maternal morbidity and mortality. (uib.no)
- Conclusion: Maternal morbidity and mortality remain challenging problems in a rural referral hospital in Tanzania. (uib.no)
- Key evidence-based interventions are not implemented in women with severe maternal morbidity and mortality. (uib.no)
- the leading causes of morbidity and mortality in critically ill patients and the most expensive condition by healthcare spending. (ieee.org)
- To determine the effectiveness of KMC in reducing morbidity and mortality among preterm neonates on CPAP via RAM nasal cannula. (alliedacademies.org)
- CHW's caregivers have demonstrated the power of a well-organized quality program that both reduces morbidity and mortality while also achieving significant cost savings," he said. (dignityhealth.org)
- Physiologic and immunologic changes predispose pregnant patients to higher risk for complications such as pneumonia, intensive care unit admission, and inpatient mortality," Wen told attendees. (medscape.com)
- Prematurity, pneumonia, complications during labour and delivery, diarrhoea, sepsis and malaria are leading causes of deaths in children under 5 years old. (weforum.org)
- In addition, Medicare has begun using risk-adjusted 30-day mortality rates, including deaths after pneumonia and heart attacks, to penalize hospitals that score poorly and reward those with good outcomes. (advisory.com)
- Based on the history and physical examination, Mr. K appeared to have an acute exacerbation of COPD secondary to pneumonia, which was further complicated by sepsis and impending septic shock. (ukessays.com)
- 1 In low-income countries, mortality in early childhood is dominated by prematurity, sepsis, and pneumonia-diseases that frequently result in hypoxemic respiratory failure. (bmj.com)
- Duke et al 3 conducted the only study that examined the effect of introducing pulse oximetry and oxygen concentrators on pneumonia-related mortality in Papua New Guinea. (bmj.com)
- Floyd et al 6 recently developed a model to evaluate the benefit of pulse oximetry in reducing childhood pneumonia mortality in resource-poor settings. (bmj.com)
- Pneumonia is the single largest cause of infectious disease death for children worldwide and accounts for 15% of U5 mortality. (livinggoods.org)
- Researchers estimated an additional 2.3 million childhood deaths from pneumonia and newborn sepsis would arise due to health system disruptions from COVID-19. (livinggoods.org)
- We aimed to further evaluate the influence of corticosteroids on mortality in adult patients with influenza pneumonia by comparing corticosteroid-treated and placebo-treated patients. (biomedcentral.com)
- In patients with influenza pneumonia, corticosteroid use is associated with higher mortality. (biomedcentral.com)
- Therefore, based on these controversial findings related to corticosteroid use in adult patients with influenza pneumonia, we conducted a systematic review and meta-analysis of all published trials that have compared mortality between influenza pneumonia patients who received corticosteroid therapy and those who did not. (biomedcentral.com)
- The major causes of emergence of multidrug-resistant organisms (MDRO) in neonatal sepsis include empiric antibiotic prescriptions, unregulated use of over-the-counter drugs, high incidence of healthcare associated infections (HAI), lack of awareness about antibiotic stewardship program and under staffing of neonatal intensive care units. (mysciencework.com)
- Interpretation Fosfomycin in combination with other antimicrobial agents offers a safe and potentially affordable regimen with a simple dosing schedule for neonatal sepsis in hospital settings. (ox.ac.uk)
- When looking specifically at rates of shock/sepsis, mechanical ventilation, and acute respiratory distress syndrome, the data revealed similar trends, with substantially higher proportions of patients with influenza experiencing these complications compared to maternal patients without influenza. (medscape.com)
- May 2016 Maternal Mortality in Developing Countries Around the world, 830 women die every day from preventable complications during pregnancy and delivery ("Maternal mortality" 1). (bartleby.com)
- By that time, her complications had worsened and she succumbed to sepsis and multiple-organ failure on Day 31. (advisory.com)
- Some experts argue that using 30-day mortality rates as a metric of surgical success can hinder patient care because doctors are disincentivized to take on high-risk patients or suggest follow-up treatment that could lead to complications. (advisory.com)
- There is strong evidence to suggest that skilled emergency care in response to obstetric complications (hemorrhage, sepsis, hypertensive disorders of pregnancy, prolonged or obstructed labor and uterine rupture) is critical in the reduction of maternal mortality. (limbsandthings.com)
- The incidence and mortality risk in CAP are linked to increasing age and the presence of age-related comorbidities and complications. (biomedcentral.com)
- pregnancy induced hypertension, sepsis and complications of abortion. (advance-africa.com)
- However, the role of IRAK1 in affecting outcome in polymicrobial sepsis is unknown. (elsevier.com)
- The study shows that IRAK1 deficiency impacts multiple TLR-dependent pathways and decreases early cytokine responses following polymicrobial sepsis. (elsevier.com)
- The delayed inflammatory response caused by the lack of IRAK1 expression is beneficial, as it manifests a marked increased chance of survival after polymicrobial sepsis. (elsevier.com)
- In Mairi Noverr's laboratory - from Tulane University, in collaboration with Fidel, vaccination with a live attenuated fungal strain-induced trained innate protection against lethal polymicrobial sepsis. (weeklyvoice.com)
- Methods: To elucidate the mechanism leading to CTL activation we used the Hepa1-6 cell line in vitro and the mouse model of in vivo polymicrobial sepsis, following cecal-ligation and -puncture (CLP) in wildtype, myeloid specific NOX-2, global NOX2 and NOX4 knockout mice, and their survival as a final readout. (uni-frankfurt.de)
- This included a higher mortality risk in postsurgical patients presenting to the intensive care unit from the hospital ward. (elsevier.com)
- This retrospective analysis of a multicenter prospective registry included adult patients with severe sepsis diagnosed outside the intensive care unit (ICU) by conventional criteria proposed in 2003. (elsevier.com)
- The analyzes of intensive care unit mortality in patients with chronic obstructive lung diseases: What are the effect of comorbidities? (ersjournals.com)
- INTRODUCTION: The mortality of patients with an exacer-bation of decompensated liver cirrhosis is high even if treated in the intensive care unit (ICU), and the criteria for referral to ICU are not well defined. (regionh.dk)
- Pediatric patients with severe sepsis were categorized into those who had recent surgery (postsurgical sepsis) versus those that did not (medical sepsis) before sepsis onset. (elsevier.com)
- Early diagnosis and rapid intervention is critical in sepsis treatment, but symptoms aren't always apparent for its early onset stages. (sas.com)
- Research has shown that providing full medical treatment for sepsis in the first 180 minutes of onset can save 80 percent of the lives that would have otherwise been lost. (sas.com)
- They're now better able to determine, for example, the probability of a bloodstream infection, such as the early onset of sepsis. (computerworld.com)
- The major tenet of sepsis care is prompt recognition and initiation of treatment, however, no clinically validated system exists for accurate, real-time prediction of sepsis onset, and considerable controversies remain concerning the effectiveness of various treatment options for septic patients. (ieee.org)
- Widespread health problems include off-the-charts maternal mortality (from obstructive labor, eclampsia, obstetric hemorrhage, and sepsis - 60% of births take place at home) and the largest outbreak of cholera in recent history, which occurred after the devastating 2010 earthquake near the capital of Port-au-Prince. (cleantechnica.com)
Organ Failure Assessment2
- Quick sequential organ failure assessment (qSOFA) was proposed in the new sepsis definition (Sepsis-3). (elsevier.com)
- Univariate Cox regression analysis showed that mortality was significantly associated with a low oxygen saturation, low diastolic blood pressure, terlipressin treatment, high Acute Physiology And Chronic Health Evaluation II score, high Simplified Acute Physiology Score II score, high Sepsis-related Organ Failure Assessment (SOFA) score and high Model For End-Stage Liver Disease score, but only a high SOFA score and old age were independently associated with increased mortality. (regionh.dk)
Reduce the mortality rate1
- Results: We observed downregulation of PD-L1 on hepatocytes in the murine sepsis model. (uni-frankfurt.de)
- Therefore, they showed that AOA-2 in combination with sub-optimal dose of colistin reduces the bacterial loads in tissues in murine peritoneal sepsis model with reduction of mice mortality rate. (reipi.org)
Surviving Sepsis C3
- Dr. R. Phillip Dellinger, a leader in the international Surviving Sepsis Campaign and the director for critical care at Cooper University Hospital, called CHW's sepsis prevention program groundbreaking. (dignityhealth.org)
- The initiative included recruitment of general surgery faculty, expansion of its Surviving Sepsis Campaign, implementation of an early warning system, initiation of a 100% mortality review, and six other measures. (ecri.org)
- She serves on the 2012 and 2016 board of the Surviving Sepsis Campaign International Guidelines. (codachange.org)
- Methods: Data were extracted from a secondary analysis of an international point prevalence study of pediatric severe sepsis. (elsevier.com)
- We hypothesized that the reduction in mortality was due to a decrease in septicemia-associated mortality.Methods:This is a secondary analysis of clinical and HRC data from 2,989 VLBW infants enrolled in a randomized clinical trial of HRC monitoring in nine NICUs from 2004 to 2010.Results:LOS was diagnosed 974 times in 700 patients, and the incidence and distribution of organisms were similar in HRC display and nondisplay groups. (elsevier.com)
Regarding in-hospital mortality1
- 2019. https://evidence.unboundmedicine.com/evidence/view/infoPOEMs/1314697/all/Improved_28_day_mortality_with_the_use_of_steroids_in_sepsis. (unboundmedicine.com)
- SPROUT Investigators & Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network 2019, ' Risk Factors for Mortality in Pediatric Postsurgical versus Medical Severe Sepsis ', Journal of Surgical Research , vol. 242, pp. 100-110. (elsevier.com)
- Racial stress has been directly linked to preterm labor and birth, infant mortality, and maternal mortality, she reported during a symposium at the Pediatric Academic Societies 2019 Meeting in Baltimore. (medscape.com)
Appalling mortality rate1
- Serum bilirubin levels on ICU admission are associated with ARDS development and mortality in sepsis. (snpedia.com)
- BVA has been shown in an RCT conducted at a Level-1 (the highest) trauma center, to be of significant benefit to lower mortality by 66% in patients who predominantly suffered from respiratory distress, sepsis, and ARDS. (technologynetworks.com)
- Simple measures are preventing infant mortality in the developing world. (weforum.org)
- The death rates from pretty much every major cause - heart disease, cancer, Alzheimer's, diabetes, suicide, sepsis, guns, infant mortality - remain highest in the South, according to updated data from the Centers for Disease Control and Prevention. (axios.com)
- Is the 30-day mortality rate a good measure of surgical success? (advisory.com)
- Some medical experts say using a hospital's 30-day mortality rate as a measure of surgical success can hamper necessary follow-up care, especially for older patients, Paula Span writes in the New York Times ' "New Old Age" blog. (advisory.com)
- A hospital's 30-day mortality number has long served as a "traditional yardstick for surgical quality," writes Span, and some states even require hospitals to publically report their 30-day mortality after certain procedures. (advisory.com)
- Some experts argue stories like that should push the industry to rethink its reliance on 30-day mortality rates as a measure of surgical success. (advisory.com)
- Abstract Maternal sepsis is preventable, yet remains the leading cause of maternal death worldwide, according to a study published in 2013 (Acosta & Knight, 2013). (bartleby.com)
- Our mission is to end preventable morbidity, mortality and racial disparities in California maternity care. (cmqcc.org)
- Ending preventable maternal and perinatal mortality is a global priority under the Sustainable Development Goals (SDG) agenda. (advance-africa.com)
- In postsurgical sepsis, older age, admission from the hospital ward, multiple organ dysfunction syndrome at sepsis recognition, and cardiovascular and respiratory comorbidities were independent risk factors for death. (elsevier.com)
- One of every three patients who dies in the hospital has sepsis. (wearable-technologies.com)
- We conducted receiver operating characteristic (ROC) analyses to assess the predictive value for in-hospital mortality and compared clinical characteristics between survivors and non-survivors with qSOFA score ≤ 1 point (qSOFA-negative). (elsevier.com)
- Sepsis is the leading cause of death for hospital patients and leading cause of readmissions. (fiercehealthcare.com)
- Here are three key steps to reducing sepsis mortality rates in your hospital. (capsuletech.com)
- Outcome measures included duration of RCPAP, and oxygen support, morbidity, mortality and length of hospital stay. (alliedacademies.org)
- Although the mortality rate and the hospital stay were reduced in the KMC group, these were not statistically significant. (alliedacademies.org)
- Systematic implementation of quality improvement best practices led to significant decreases in risk-adjusted mortality and early death in a general surgery population at a safety-net hospital in Philadelphia, according to a study in the March 2017 issue of Surgery . (ecri.org)
- CONCLUSIONS: In this study we found similar in-hospital and ICU mortality, as well as risk factors for mortality, compared to previous reports. (bvsalud.org)
- Furthermore, mortality rate over time was mainly due to the availability of ICU beds, indirectly suggesting that overcrowding was one of the main factors that contributed to hospital mortality. (bvsalud.org)
- Southern Asia has the second-highest under-five mortality rate in the world - about 1 child in 19 dies before age five. (weforum.org)
- From 2008 to 2015 Rwanda cut its newborn mortality rate by 30%, and it was the result of simple steps. (weforum.org)
- We have to acknowledge tremendous global progress, especially since 2000 when many countries have tripled the rate of reduction of under-five mortality," said the Deputy Executive Director of the UN Children's Fund ( UNICEF ), Geeta Rao Gupta, on the Child Mortality Report. (weforum.org)
- Does aspiration have any influence on the mortality rate of patients in prolonged weaning? (ersjournals.com)
- Every effort was made to safeguard their wellbeing as much as possible: the entire procedure had a zero mortality rate, and the animals displayed the full range of natural behaviors in aquaculture while maintaining their body weight. (eurekalert.org)
- The 28-day mortality rate was 40% in the TPE group versus 65% in the standard care group (p=0.043). (researchsquare.com)
- The leak rate is a marker of the rate at which fluids may be escaping the intravascular space -- high rates of capillary permeability have been shown to be a significant prognostic marker of ICU mortality. (technologynetworks.com)
- Evidence demonstrates that mortality rates can be significantly reduced if septic patients are identified in the early stages of the disease progression. (capsuletech.com)
- After instituting a strict policy of hand-washing with a chlorinated antiseptic solution, mortality rates dropped from 7.8% to 1.8% within 3 months, demonstrating that transfer of disease could be significantly reduced by this simple hygienic practice. (verywellhealth.com)
Reduction in mortality2
- Notably, a portion of the observed reduction in mortality may also be related to the improved overall level of care children receive in a quality improvement initiative. (bmj.com)
- Continuously monitoring an HRC index leads to a reduction in mortality among very low birth weight (VLBW) infants. (elsevier.com)
- 113/603 (18.7%) of patients assigned albumin were treated with renal replacement therapy compared to 112/615 (18.2%) assigned saline (p = 0.98).The unadjusted relative risk of death for albumin versus saline was 0.87 [95% confidence interval (CI) 0.74-1.for patients with severe sepsis and 1.05 (0.94-1.17) for patients without severe sepsis (p = 0.06 for heterogeneity). (edu.au)
- 400 pg/ml) had an increased mortality risk (hazard ratio (HR) 1.690, 95% confidence interval (CI) 1.017-2.809, P = 0.043). (uni-frankfurt.de)
- Every September, the UN announces the number of children under five who died the previous year in its Child Mortality Report . (weforum.org)
- In fact, child mortality rates have more than halved since 1990 . (weforum.org)
- In their latest annual letter to their biggest single contributor, Warren Buffet, they explain how initiatives in Rwanda have contributed to the reduction in child mortality. (weforum.org)
- There were fewer large, abrupt increases in the HRC index in the days leading up to LOS diagnosis in infants whose HRC index was displayed.Conclusion:Continuous HRC monitoring is associated with a lower septicemia-associated mortality in VLBW infants, possibly due to diagnosis earlier in the course of illness. (elsevier.com)
- Mortality rates increase 8 percent for every hour treatment is delayed. (sas.com)
- One study found that high-performing organizations in heart attack care, as measured by improved mortality rates, generally had features such as good communication and coordination, shared values and culture, and experience with problem solving and learning (Curry et al. (nap.edu)
- Sepsis rates have doubled in the past 15 years. (mentalhelp.net)