Molecular motor proteins. Medical search

Proteins that are involved in or cause CELL MOVEMENT such as the rotary structures (flagellar motor) or the structures whose movement is directed along cytoskeletal filaments (MYOSIN; KINESIN; and DYNEIN motor families).

A microtubule-associated mechanical adenosine triphosphatase, that uses the energy of ATP hydrolysis to move organelles along microtubules toward the plus end of the microtubule. The protein is found in squid axoplasm, optic lobes, and in bovine brain. Bovine kinesin is a heterotetramer composed of two heavy (120 kDa) and two light (62 kDa) chains. EC 3.6.1.-.

A subclass of myosin involved in organelle transport and membrane targeting. It is abundantly found in nervous tissue and neurosecretory cells. The heavy chains of myosin V contain unusually long neck domains that are believed to aid in translocating molecules over large distances.

A family of multisubunit cytoskeletal motor proteins that use the energy of ATP hydrolysis to power a variety of cellular functions. Dyneins fall into two major classes based upon structural and functional criteria.

Slender, cylindrical filaments found in the cytoskeleton of plant and animal cells. They are composed of the protein TUBULIN and are influenced by TUBULIN MODULATORS.

Neurons which activate MUSCLE CELLS.

A diverse superfamily of proteins that function as translocating proteins. They share the common characteristics of being able to bind ACTINS and hydrolyze MgATP. Myosins generally consist of heavy chains which are involved in locomotion, and light chains which are involved in regulation. Within the structure of myosin heavy chain are three domains: the head, the neck and the tail. The head region of the heavy chain contains the actin binding domain and MgATPase domain which provides energy for locomotion. The neck region is involved in binding the light-chains. The tail region provides the anchoring point that maintains the position of the heavy chain. The superfamily of myosins is organized into structural classes based upon the type and arrangement of the subunits they contain.

The electrical response evoked in a muscle or motor nerve by electrical or magnetic stimulation. Common methods of stimulation are by transcranial electrical and TRANSCRANIAL MAGNETIC STIMULATION. It is often used for monitoring during neurosurgery.

Area of the FRONTAL LOBE concerned with primary motor control located in the dorsal PRECENTRAL GYRUS immediately anterior to the central sulcus. It is comprised of three areas: the primary motor cortex located on the anterior paracentral lobule on the medial surface of the brain; the premotor cortex located anterior to the primary motor cortex; and the supplementary motor area located on the midline surface of the hemisphere anterior to the primary motor cortex.

A technique that uses LASERS to trap, image, and manipulate small objects (biomolecules, supramolecular assembles, DENDRIMERS) in three dimensional space. (From Glossary of Biotechnology and Nanobiotechnology Terms, 4th ed.)

A subclass of myosins found generally associated with actin-rich membrane structures such as filopodia. Members of the myosin type I family are ubiquitously expressed in eukaryotes. The heavy chains of myosin type I lack coiled-coil forming sequences in their tails and therefore do not dimerize.

High molecular weight proteins found in the MICROTUBULES of the cytoskeletal system. Under certain conditions they are required for TUBULIN assembly into the microtubules and stabilize the assembled microtubules.

The larger subunits of MYOSINS. The heavy chains have a molecular weight of about 230 kDa and each heavy chain is usually associated with a dissimilar pair of MYOSIN LIGHT CHAINS. The heavy chains possess actin-binding and ATPase activity.

The act, process, or result of passing from one place or position to another. It differs from LOCOMOTION in that locomotion is restricted to the passing of the whole body from one place to another, while movement encompasses both locomotion but also a change of the position of the whole body or any of its parts. Movement may be used with reference to humans, vertebrate and invertebrate animals, and microorganisms. Differentiate also from MOTOR ACTIVITY, movement associated with behavior.

Dyneins that are responsible for intracellular transport, MITOSIS, cell polarization, and movement within the cell.

The physical activity of a human or an animal as a behavioral phenomenon.

Sensory cells of organ of Corti. In mammals, they are usually arranged in three or four rows, and away from the core of spongy bone (the modiolus), lateral to the INNER AUDITORY HAIR CELLS and other supporting structures. Their cell bodies and STEREOCILIA increase in length from the cochlear base toward the apex and laterally across the rows, allowing differential responses to various frequencies of sound.

An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.

Physical motion, i.e., a change in position of a body or subject as a result of an external force. It is distinguished from MOVEMENT, a process resulting from biological activity.

Filamentous proteins that are the main constituent of the thin filaments of muscle fibers. The filaments (known also as filamentous or F-actin) can be dissociated into their globular subunits; each subunit is composed of a single polypeptide 375 amino acids long. This is known as globular or G-actin. In conjunction with MYOSINS, actin is responsible for the contraction and relaxation of muscle.

Proteins found in the microtubules.

The subfamily of myosin proteins that are commonly found in muscle fibers. Myosin II is also involved a diverse array of cellular functions including cell division, transport within the GOLGI APPARATUS, and maintaining MICROVILLI structure.

Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.

The directed transport of ORGANELLES and molecules along nerve cell AXONS. Transport can be anterograde (from the cell body) or retrograde (toward the cell body). (Alberts et al., Molecular Biology of the Cell, 3d ed, pG3)

A microtubule structure that forms during CELL DIVISION. It consists of two SPINDLE POLES, and sets of MICROTUBULES that may include the astral microtubules, the polar microtubules, and the kinetochore microtubules.

The process of moving proteins from one cellular compartment (including extracellular) to another by various sorting and transport mechanisms such as gated transport, protein translocation, and vesicular transport.

A group of enzymes which catalyze the hydrolysis of ATP. The hydrolysis reaction is usually coupled with another function such as transporting Ca(2+) across a membrane. These enzymes may be dependent on Ca(2+), Mg(2+), anions, H+, or DNA.

Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.

A processive single-headed motor: kinesin superfamily protein KIF1A. (1/1515)

A single kinesin molecule can move "processively" along a microtubule for more than 1 micrometer before detaching from it. The prevailing explanation for this processive movement is the "walking model," which envisions that each of two motor domains (heads) of the kinesin molecule binds coordinately to the microtubule. This implies that each kinesin molecule must have two heads to "walk" and that a single-headed kinesin could not move processively. Here, a motor-domain construct of KIF1A, a single-headed kinesin superfamily protein, was shown to move processively along the microtubule for more than 1 micrometer. The movement along the microtubules was stochastic and fitted a biased Brownian-movement model. (+info)

Microtubule-dependent plus- and minus end-directed motilities are competing processes for nuclear targeting of adenovirus. (2/1515)

Adenovirus (Ad) enters target cells by receptor-mediated endocytosis, escapes to the cytosol, and then delivers its DNA genome into the nucleus. Here we analyzed the trafficking of fluorophore-tagged viruses in HeLa and TC7 cells by time-lapse microscopy. Our results show that native or taxol-stabilized microtubules (MTs) support alternating minus- and plus end-directed movements of cytosolic virus with elementary speeds up to 2.6 micrometer/s. No directed movement was observed in nocodazole-treated cells. Switching between plus- and minus end-directed elementary speeds at frequencies up to 1 Hz was observed in the periphery and near the MT organizing center (MTOC) after recovery from nocodazole treatment. MT-dependent motilities allowed virus accumulation near the MTOC at population speeds of 1-10 micrometer/min, depending on the cell type. Overexpression of p50/dynamitin, which is known to affect dynein-dependent minus end-directed vesicular transport, significantly reduced the extent and the frequency of minus end-directed migration of cytosolic virus, and increased the frequency, but not the extent of plus end-directed motility. The data imply that a single cytosolic Ad particle engages with two types of MT-dependent motor activities, the minus end- directed cytoplasmic dynein and an unknown plus end- directed activity. (+info)

The polar flagellar motor of Vibrio cholerae is driven by an Na+ motive force. (3/1515)

Vibrio cholerae is a highly motile bacterium which possesses a single polar flagellum as a locomotion organelle. Motility is thought to be an important factor for the virulence of V. cholerae. The genome sequencing project of this organism is in progress, and the genes that are highly homologous to the essential genes of the Na+-driven polar flagellar motor of Vibrio alginolyticus were found in the genome database of V. cholerae. The energy source of its flagellar motor was investigated. We examined the Na+ dependence and the sensitivity to the Na+ motor-specific inhibitor of the motility of the V. cholerae strains and present the evidence that the polar flagellar motor of V. cholerae is driven by an Na+ motive force. (+info)

p53 and p16INK4A mutations during the progression of glomus tumor. (4/1515)

Glomus tumors are significantly rare tumors of carotid body. The great majority of these tumors are benign in character. Here we present two brothers with hereditary glomus jugulare tumor who had consanguineous parents. Radiotherapy was applied approximately 8 and 10 years ago for treatment in both cases. Eight years later, one of these cases came to our notice due to relapse. The mutation pattern of p53, p57KIP2, p16INK4A and p15NK4B genes which have roles in the cell cycle, was analyzed in tumor samples obtained from the two affected cases in the initial phase and from one of these cases at relapse. The DNA sample obtained from the case in initial diagnosis phase revealed no p53, p57KIP2, p16INK4A or p15INK4B mutation. He is still in remission phase. Despite the lack of p53, p57KIP2, p16INK4A and p15INK4B mutation at initial diagnosis the tumor DNA of the other case in relapse revealed p53 codon 243 (ATG-->ATC; met-->ile) and p16 codon 97 (GAC-->AAC; asp-->asn) missense point mutations. No loss of heterozygosity in p53 and p16INK4A was observed by microsatellite analysis of tumoral tissues in these cases. P53 and p16INK4A mutations observed in relapse phase were in conserved regions of both genes. No previous reports have been published with these mutations in glomus tumor during progression. The mutation observed in this case may due to radiotherapy. In spite of this possibility, the missense point mutations in conserved region of p53 and p16INK4A genes may indicate the role of p53 and p16INK4A in tumor progression of glomus tumors. (+info)

The meningococcal PilT protein is required for induction of intimate attachment to epithelial cells following pilus-mediated adhesion. (5/1515)

The ability of Neisseria meningitidis (MC) to interact with cellular barriers is essential to its pathogenesis. With epithelial cells, this process has been modeled in two steps. The initial stage of localized adherence is mediated by bacterial pili. After this phase, MC disperse and lose piliation, thus leading to a diffuse adherence. At this stage, microvilli have disappeared, and MC interact intimately with cells and are, in places, located on pedestals of actin, thus realizing attaching and effacing (AE) lesions. The bacterial attributes responsible for these latter phenotypes remain unidentified. Considering that bacteria are nonpiliated at this stage, pili cannot be directly responsible for this effect. However, the initial phase of pilus-mediated localized adherence is required for the occurrence of diffuse adherence, loss of microvilli, and intimate attachment, because nonpiliated bacteria are not capable of such a cellular interaction. In this work, we engineered a mutation in the cytoplasmic nucleotide-binding protein PilT and showed that this mutation increased piliation and abolished the dispersal phase of bacterial clumps as well as the loss of piliation. Furthermore, no intimate attachment nor AE lesions were observed. On the other hand, PilT- MC remained adherent as piliated clumps at all times. Taken together these data demonstrate that the induction of diffuse adherence, intimate attachment, and AE lesions after pilus-mediated adhesion requires the cytoplasmic PilT protein. (+info)

Differences in the ionic interaction of actin with the motor domains of nonmuscle and muscle myosin II. (6/1515)

Changes in the actin-myosin interface are thought to play an important role in microfilament-linked cellular movements. In this study, we compared the actin binding properties of the motor domain of Dictyostelium discoideum (M765) and rabbit skeletal muscle myosin subfragment-1 (S1). The Dictyostelium motor domain resembles S1(A2) (S1 carrying the A2 light chain) in its interaction with G-actin. Similar to S1(A2), none of the Dictyostelium motor domain constructs induced G-actin polymerization. The affinity of monomeric actin (G-actin) was 20-fold lower for M765 than for S1(A2) but increasing the number of positive charges in the loop 2 region of the D. discoideum motor domain (residues 613-623) resulted in equivalent affinities of G-actin for M765 and for S1. Proteolytic cleavage and cross-linking approaches were used to show that M765, like S1, interacts via the loop 2 region with filamentous actin (F-actin). For both types of myosin, F-actin prevents trypsin cleavage in the loop 2 region and F-actin segment 1-28 can be cross-linked to loop 2 residues by a carbodiimide-induced reaction. In contrast with the S1, loop residues 559-565 of D. discoideum myosin was not cross-linked to F-actin, probably due to the lower number of positive charges. These results confirm the importance of the loop 2 region of myosin for the interaction with both G-actin and F-actin, regardless of the source of myosin. The differences observed in the way in which M765 and S1 interact with actin may be linked to more general differences in the structure of the actomyosin interface of muscle and nonmuscle myosins. (+info)

GMAP-210, A cis-Golgi network-associated protein, is a minus end microtubule-binding protein. (7/1515)

We report that a peripheral Golgi protein with a molecular mass of 210 kD localized at the cis-Golgi network (Rios, R.M., A.M. Tassin, C. Celati, C. Antony, M.C. Boissier, J.C. Homberg, and M. Bornens. 1994. J. Cell Biol. 125:997-1013) is a microtubule-binding protein that associates in situ with a subpopulation of stable microtubules. Interaction of this protein, now called GMAP-210, for Golgi microtubule-associated protein 210, with microtubules in vitro is direct, tight and nucleotide-independent. Biochemical analysis further suggests that GMAP-210 specifically binds to microtubule ends. The full-length cDNA encoding GMAP-210 predicts a protein of 1, 979 amino acids with a very long central coiled-coil domain. Deletion analyses in vitro show that the COOH terminus of GMAP-210 binds to microtubules whereas the NH2 terminus binds to Golgi membranes. Overexpression of GMAP-210-encoding cDNA induced a dramatic enlargement of the Golgi apparatus and perturbations in the microtubule network. These effects did not occur when a mutant lacking the COOH-terminal domain was expressed. When transfected in fusion with the green fluorescent protein, the NH2-terminal domain associated with the cis-Golgi network whereas the COOH-terminal microtubule-binding domain localized at the centrosome. Altogether these data support the view that GMAP-210 serves to link the cis-Golgi network to the minus ends of centrosome-nucleated microtubules. In addition, this interaction appears essential for ensuring the proper morphology and size of the Golgi apparatus. (+info)

The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex. (8/1515)

Bcl-2 family members that have only a single Bcl-2 homology domain, BH3, are potent inducers of apoptosis, and some appear to play a critical role in developmentally programmed cell death. We examined the regulation of the proapoptotic activity of the BH3-only protein Bim. In healthy cells, most Bim molecules were bound to LC8 cytoplasmic dynein light chain and thereby sequestered to the microtubule-associated dynein motor complex. Certain apoptotic stimuli disrupted the interaction between LC8 and the dynein motor complex. This freed Bim to translocate together with LC8 to Bcl-2 and to neutralize its antiapoptotic activity. This process did not require caspase activity and therefore constitutes an initiating event in apoptosis signaling. (+info)

Transport by molecular motor proteins (Kinesin, Dynein and unconventional Myosin) is essential for cell functioning and ... Studies of multiple motors are inspired by the fact that multiple motors are involved in many biological processes such as ... Klumpp S, Lipowsky R (November 2005). "Cooperative cargo transport by several molecular motors". Proceedings of the National ... This increasing interest in modeling multiple motor transport is particularly due to improved understanding of single motor ...

https://en.wikipedia.org/wiki/Transport_by_multiple-motor_proteins

... and proteins), enzymes, and molecular motors. When a microscopic machine (e.g. a MEM) performs useful work it generates heat ... For example, biomolecules within cells are coupled with an active bath due to the presence of molecular motors within the ... Seifert, Udo (2012). "Stochastic thermodynamics, fluctuation theorems and molecular machines". Reports on Progress in Physics. ... protein folding might be facilitated by the presence of active fluctuations (Harder et al., 2014b) and active matter dynamics ...

https://en.wikipedia.org/wiki/Stochastic_thermodynamics

... is a molecular motor protein that is essential in mitosis. In humans it is coded for by the gene ... Vale RD (1996). "Switches, latches, and amplifiers: common themes of G proteins and molecular motors". J Cell Biol. 135 (2): ... The motor domain or motor head is at the N-terminus and performs ATP hydrolysis and binds to microtubules. Kinesin-5 motors ... Ferhat L, Cook C, Chauviere M, Harper M, Kress M, Lyons GE, Baas PW (October 1998). "Expression of the mitotic motor protein ...

https://en.wikipedia.org/wiki/Kinesin-like_protein_KIF11

Helicases are proteins that are a type of molecular motor. They use the chemical energy in nucleoside triphosphates, ... All the functions of DNA depend on interactions with proteins. These protein interactions can be non-specific, or the protein ... Martinez E (December 2002). "Multi-protein complexes in eukaryotic gene transcription". Plant Molecular Biology. 50 (6): 925-47 ... ISBN 978-0-521-58519-4. Sjölander K (January 2004). "Phylogenomic inference of protein molecular function: advances and ...

https://en.wikipedia.org/wiki/DNA

Lodish, H; Berk, A; Zipursky, SL (2000). "Microtubule dynamics and motor proteins during mitosis". Molecular Cell Biology (4th ... Tubulin protein polymers are the major component of microtubules. During mitosis, microtubules form the organizing structure ...

https://en.wikipedia.org/wiki/Moroidin

"Motor Proteins and Molecular Motors," (A.B. Kolomeisky), CRC Press, Taylor and Francis, 2015. "APS Fellow Archive". American ... In 2015 he wrote a book "Motor Proteins in Molecular Motors." He is currently the editor of the Biophysical Journal. He also ... developed a first theoretical description of the force generation mechanisms by motor proteins and biological molecular motors ... Kolomeisky, Anatoly B.; Fisher, Michael E. (2007). "Molecular Motors: A Theorist's Perspective". Annual Review of Physical ...

https://en.wikipedia.org/wiki/Anatoly_B._Kolomeisky

In molecular biology, the flagellar motor switch protein (Flig) is one of three proteins in certain bacteria coded for by the ... "fliN - Flagellar motor switch protein FliN - Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) - fliN gene & protein ... The other two proteins are FliN coded for by fliN, and FliM coded for by fliM. The protein complex regulates the direction of ... CheY, the chemotaxis response regulator, is believed to act directly on the switch to induce a switch in the flagellar motor ...

https://en.wikipedia.org/wiki/Flagellar_motor_switch_protein

2007). "Differential expression of molecular motors in the motor cortex of sporadic ALS". Neurobiol. Dis. 26 (3): 577-89. doi: ... This motor consists of two kinesin-related subunits (called KIF3A and KIF3B or 3C in vertebrates) and an associated protein ( ... Work done in a broad range of eukaryotic cells has revealed that heterotrimeric kinesin-2 is the primary motor protein driving ... KIF3A is one subunit of the heterotrimeric motor protein, kinesin-2, that was initially isolated from sea urchin egg/embryo ...

https://en.wikipedia.org/wiki/Kinesin-like_protein_KIF3A

A number of theoretical models of the molecular motor protein kinesin have been proposed. Many challenges are encountered in ... Vale RD, Milligan RA (April 2000). "The way things move: looking under the hood of molecular motor proteins". Science. 288 ( ... Motor proteins fulfill the role of transporting large cargo about the cell to their required destinations. Kinesins are motor ... A kinesin is a protein belonging to a class of motor proteins found in eukaryotic cells. Kinesins move along microtubule (MT) ...

https://en.wikipedia.org/wiki/Kinesin

Vale, R. D.; Milligan, R. A. (2000). "The Way Things Move: Looking Under the Hood of Molecular Motor Proteins". Science. 288 ( ... These proteins were attached to one micron microspheres tagged with a synthetic peptide. Consequently, they accomplished the ... One of the more well-known living microsystems are swimming bacteria, but directed motion occurs even at the molecular scale, ... Inspired by the composition of adhesive proteins in mussels, dopamine self-polymerization into polydopamine is currently the ...

https://en.wikipedia.org/wiki/Biohybrid_microswimmer

Energy Coupling and Molecular Motors. The Enzymes. Energy Coupling and Molecular Motors. Vol. 23. Academic Press. pp. 277-302. ... This highly processive DNA polymerase was composed of an 84-kDa T7 gene 5 protein and 12-kDa E. coli thioredoxin at a one-to- ... 1986-1995 American Society for Biochemistry and Molecular Biology-Merck Award in Biochemistry and Molecular Biology, 1996 ... Richardson used the T7 RNA polymerase/promoter system to control the expression of a phage T7 gene 5 protein (gp5), which is a ...

https://en.wikipedia.org/wiki/Charles_C._Richardson

Myosin filaments act as molecular motors and by binding to actin enables filament sliding. Furthermore, members of the skeletal ... complex Protein domain dynamics Protein flexibility Protein structure Protein-protein interaction prediction Protein-protein ... Protein-Protein Interaction Databases Library of Modulators of Protein-Protein Interactions (PPI) Proteins and Enzymes at ... Visualization and integration of protein-protein interactions. In: Golemis, E. (ed.) Protein-Protein Interactions - A Molecular ...

https://en.wikipedia.org/wiki/Protein–protein_interaction

In networks-based biocomputation, self-propelled biological agents, such as molecular motor proteins or bacteria, explore a ... For instance, in the system described by Nicolau et al., mobile molecular motor filaments are detected at the "exits" of a ... "Parallel computation with molecular-motor-propelled agents in nanofabricated networks". Proceedings of the National Academy of ... The chemical nature of a protein is dictated by its sequence of amino acids-the chemical building blocks of proteins. This ...

https://en.wikipedia.org/wiki/Biological_computing

The Kinesin 8 Family are a subfamily of the molecular motor proteins known as kinesins. Most kinesins transport materials or ... Video Illustrations of Kinesin 8 depletion (Use dmy dates from April 2022, Motor proteins). ... Kinesin 8 is thought to play some role in this process, as knockdown of this protein via siRNA produces a phenotype of sister ... Stumpff J, von Dassow G, Wagenbach M, Asbury C, Wordeman L (February 2008). "The kinesin-8 motor Kif18A suppresses kinetochore ...

https://en.wikipedia.org/wiki/Kinesin_8

The molecular motor Myosin Va interacts with the cilia-centrosomal protein RPGRIP1L. Sci. Rep. 7, 43692; doi: 10.1038/srep43692 ... Unconventional myosin-Va is a motor protein in charge of the intracellular transport of vesicles, organelles and protein ... "A Role for Myosin V Motor Proteins in the Selective Delivery of Kv Channel Isoforms to the Membrane Surface of Cardiac Myocytes ... "Molecular cloning and characterization of neural activity-related RING finger protein (NARF): a new member of the RBCC family ...

https://en.wikipedia.org/wiki/Unconventional_myosin-Va

Molecular machines Molecular mechanics Molecular propeller Motor proteins Nanomotor Protein dynamics Synthetic molecular motors ... One important difference between molecular motors and macroscopic motors is that molecular motors operate in the thermal bath, ... A database for cytoskeletal and motor protein sequence information Jonathan Howard (2001), Mechanics of motor proteins and the ... Because the motor events are stochastic, molecular motors are often modeled with the Fokker-Planck equation or with Monte Carlo ...

https://en.wikipedia.org/wiki/Molecular_motor

MBInfo - What are Motor Proteins? Ron Vale's Seminar: "Molecular Motor Proteins" Biology of Motor Proteins Institute for ... Motor proteins are a class of molecular motors that can move along the cytoplasm of animal cells. They convert chemical energy ... The building of cell plate and ultimately the new cell wall requires kinesin-like motor proteins. Another motor protein ... The best prominent example of a motor protein is the muscle protein myosin which "motors" the contraction of muscle fibers in ...

https://en.wikipedia.org/wiki/Motor_protein

... protein and a specific subset of spliceosomal Sm proteins". Human Molecular Genetics. 9 (13): 1977-86. doi:10.1093/hmg/9.13. ... survival of motor neuron protein, includes at least six other proteins (gem-associated protein 2, 3, 4, 5, 6 and 7. SMN has ... Survival of motor neuron or survival motor neuron (SMN) is a protein that in humans is encoded by the SMN1 and SMN2 genes. SMN ... "Neuronal-specific roles of the survival motor neuron protein: evidence from survival motor neuron expression patterns in the ...

https://en.wikipedia.org/wiki/Survival_of_motor_neuron

2017). "The molecular motor Myosin Va interacts with the cilia-centrosomal protein RPGRIP1L". Sci. Rep. 7: 43692. Bibcode: ... The protein encoded by this gene is localized to primary cilia and centrosomes in ciliated human epithelial kidney cells and ... The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 6 (1): 63-70. ... v t e (Articles with short description, Short description matches Wikidata, Protein pages needing a picture, Genes on human ...

https://en.wikipedia.org/wiki/RPGRIP1L

Motor proteins are a class of molecular motors that can move along the cytoplasm of animal cells. They convert chemical energy ... A good example is the muscle protein myosin which "motors" the contraction of muscle fibers in animals. Motor proteins are the ... These molecular motors are the essential agents of movement in living organisms. In general terms, a motor is a device that ... many protein-based molecular motors harness the chemical free energy released by the hydrolysis of ATP in order to perform ...

https://en.wikipedia.org/wiki/Molecular_biophysics

This gene encodes a member of the unconventional myosin protein family, which are actin-based molecular motors. The protein is ... 2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi: ... The mouse ortholog of this protein also functions in intracellular vesicle transport to the plasma membrane. Multiple ... Myosin-Ic is a protein that in humans is encoded by the MYO1C gene. ...

https://en.wikipedia.org/wiki/MYO1C

Through a mechanism not yet fully understood, cAMP influences other proteins such as protein kinase A to drive molecular motors ... forms complexes with molecular motors on organelles". Current Biology. 14 (20): 1877-81. doi:10.1016/j.cub.2004.10.003. PMID ... When this protein is defective, no melanin can be generated resulting in certain types of albinism. In some amphibian species ... If these proteins are defective, chromatophores may be regionally or entirely absent, resulting in a leucistic disorder. ...

https://en.wikipedia.org/wiki/Chromatophore

2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. ... Myosin VI, being a motor protein, focuses its interactions by moving along actin filaments. This however does not limit its ... Unconventional myosin-VI, is a protein that in humans is coded for by MYO6. Unconventional myosin-VI is a myosin molecular ... ". "Protein: MYO6_HUMAN (Q9UM54)". Pfam. European Molecular Biology Laboratory. Zakrzewski P, Lenartowska M, Buss F (March 2021 ...

https://en.wikipedia.org/wiki/Unconventional_myosin-VI

DNA motor proteins often experience roadblocks, including binding proteins that can interfere with essential biological ... Her research considers biological molecular motors, including RNA polymerase molecules which move along the DNA template during ... Wang has pioneered several structural probes to better understand molecular motors, including angular optical trapping, DNA ... Her research considers biomolecular motors and single molecule optical trapping techniques. She was appointed Fellow of the ...

https://en.wikipedia.org/wiki/Michelle_Wang

Accessory proteins including motor proteins regulate and link the filaments to other cell compounds and each other and are ... Also, the dynein arms attached to the microtubules function as the molecular motors. The motion of the cilia and flagella is ... During contraction of a muscle, within each muscle cell, myosin molecular motors collectively exert forces on parallel actin ... Actin-like proteins are actin in eukaryotes and MreB, FtsA in prokaryotes. An example of a WACA-proteins, which are mostly ...

https://en.wikipedia.org/wiki/Cytoskeleton

The protein encoded by this gene belongs to the myosin superfamily. Myosins are molecular motors that, upon interaction with ... 1990). "Immunochemical evidence that myosin I heavy chain-like protein is identical to the 110-kilodalton brush-border protein ... Following the motor domain is a light-chain-binding 'neck' region containing 1-6 copies of a repeat element, the IQ motif, that ... The myosin-Ia protein is expressed by enterocytes, the epithelial cells that line the luminal surface of the small intestine. ...

https://en.wikipedia.org/wiki/Unconventional_myosin-Ia

"The Ewing's sarcoma protein interacts with the Tudor domain of the survival motor neuron protein". Molecular Brain Research. ... and FUS proteins are members of the FET protein family of RNA binding proteins. They are partners in various fusion proteins ... Molecular and Cellular Changes in the Cancer Cell. Progress in Molecular Biology and Translational Science. Vol. 144. 2016. doi ... "Molecular Pathology of Bone and Soft Tissue Tumors". Cell and Tissue Based Molecular Pathology. Elsevier. pp. 325-359. doi: ...

https://en.wikipedia.org/wiki/Extraskeletal_myxoid_chondrosarcoma

For example, rotary molecular motors attached to protein-based tails called flagella can propel bacteria. In a similar way, the ... Molecular modelling Molecular motor Nanocar Nanotechnology J. Vacek and J. Michl, A molecular "Tinkertoy" construction kit: ... Molecular propellers can be rotated by molecular motors that can be driven by chemical, biological, optical and electrical ... assembly of a molecular propeller and a molecular motor can form a nanoscale machine that can pump fluids or perform locomotion ...

https://en.wikipedia.org/wiki/Molecular_propeller

This family of proteins are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes ... Kinesin-like protein KIF22 is a protein that in humans is encoded by the KIF22 gene. The protein encoded by this gene is a ... The C-terminal half of this protein has been shown to bind DNA. Studies with the Xenopus homolog suggests an essential role in ... Miki H, Setou M, Kaneshiro K, Hirokawa N (June 2001). "All kinesin superfamily protein, KIF, genes in mouse and human". Proc ...

https://en.wikipedia.org/wiki/KIF22

... endocytosis and molecular motors". The Journal of Experimental Biology. 206 (Pt 12): 2073-2082. doi:10.1242/jeb.00298. PMID ... August 2016). "GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling". Cell. 166 (4): 907-919. doi: ... July 2013). "Light-regulated stapled peptides to inhibit protein-protein interactions involved in clathrin-mediated endocytosis ... The development of photoswitchable peptide inhibitors of protein-protein interactions involved in clathrin-mediated endocytosis ...

https://en.wikipedia.org/wiki/Receptor-mediated_endocytosis

Ten-m3 protein is expressed in the Purkinje's cell zone, molecular and granular layers and the white matter of the cerebellum. ... Furthermore, the null mutant mice display delayed motor skill acquisition in the accelerating rotorod task. In in vivo ... "Teneurin proteins possess a carboxy terminal sequence with neuromodulatory activity". Molecular Brain Research. 133 (2): 253-65 ... The proteins were called Ten-ms in zebrafish, teneurins in chicken, Ten-m1-4, Odz1-4, Ten-m/Odz1-4, DOC4 in mouse, neurestin in ...

https://en.wikipedia.org/wiki/TENM3

Burn DJ, Jaros E (December 2001). "Multiple system atrophy: cellular and molecular pathology". Molecular Pathology. 54 (6): 419 ... Tau proteins have been found in some glial cytoplasmic inclusion bodies. Clinical diagnostic criteria were defined in 1998 and ... Approximately 60% of patients require a wheelchair within five years of onset of the motor symptoms, and few patients survive ... Burn DJ, Jaros E (December 2001). "Multiple system atrophy: cellular and molecular pathology". Molecular Pathology. 54 (6): 419 ...

https://en.wikipedia.org/wiki/Multiple_system_atrophy

Cell and Molecular Biology of Catalytic Proteins. Oxford University Press. ISBN 0-19-850229-X. Berg J, Tymoczko J, Stryer L ( ... Capaldi RA, Aggeler R (March 2002). "Mechanism of the F(1)F(0)-type ATP synthase, a biological rotary motor". Trends in ... Proteins are made of amino acids arranged in a linear chain joined by peptide bonds. Many proteins are enzymes that catalyze ... In prokaryotes, these proteins are found in the cell's inner membrane. These proteins use the energy from reduced molecules ...

https://en.wikipedia.org/wiki/Metabolism

To recognize protein as designated substrate, 19S complex has subunits that are capable to recognize proteins with a special ... Gridley T, Gray DA, Orr-Weaver T, Soriano P, Barton DE, Francke U, Jaenisch R (May 1990). "Molecular analysis of the Mov 34 ... Ikeda, K; Akiyama, H; Arai, T; Ueno, H; Tsuchiya, K; Kosaka, K (July 2002). "Morphometrical reappraisal of motor neuron system ... Accordingly, misfolded proteins and damaged protein need to be continuously removed to recycle amino acids for new synthesis; ...

https://en.wikipedia.org/wiki/PSMD7

... a mechanism of regulation of the motor protein cytoplasmic dynein by attachment to its anchor protein in fission yeast and most ... Tolić completed her Diploma in Molecular Biology from the University of Zagreb, Croatia in 1996 and her Graduate Studies in ... known for her work on the microtubule cytoskeleton and associated motor proteins. She is currently Senior Research Group Leader ... out pioneering research in the field of cell biology pertaining to the microtubule cytoskeleton and associated motor proteins, ...

https://en.wikipedia.org/wiki/Iva_Tolić

The Φ29 packaging motor is structurally composed of the procapsid and the connector proteins, which interact with the pRNA, the ... Due to its small size and complex morphology, it has become an ideal model for the study of many processes in molecular biology ... The structure of Φ29 is composed of seven main proteins: the terminal protein (p3), the head or capsid protein (p8), the head ... the portal or connector protein (p10), the tail tube or lower collar proteins (p11), and the tail fibers or appendage proteins ...

https://en.wikipedia.org/wiki/Bacillus_virus_phi29

There is also a group of tracers that consist of protein products that can be taken up by the cell and transported across the ... Those can also be genetic or molecular tracers. Recently manganese-enhanced magnetic resonance imaging (MEMRI) has been used to ... a subunit of the conventional kinesin microtubule-based motor". NeuroImage. 145 (Pt A): 44-57. doi:10.1016/j.neuroimage.2016.09 ... virus or protein can be locally injected, after which it is allowed to be transported anterogradely. Viral tracers can cross ...

https://en.wikipedia.org/wiki/Anterograde_tracing

mtDNA is packaged with proteins which appear to be as protective as proteins of the nuclear chromatin. Moreover, mitochondria ... Thus oxidative damage to mtDNA of motor neurons may be a significant factor in the etiology of ALS. Over the past decade, an ... Xu, X.; Arnason, U. (1 May 1996). "A complete sequence of the mitochondrial genome of the western lowland gorilla". Molecular ... InterMitoBase: an annotated database and analysis platform of protein-protein interactions for human mitochondria. (apparently ...

https://en.wikipedia.org/wiki/Mitochondrial_DNA

Ford Motor Company has announced a battery center of excellence, meant to centralize a cross-functional team to accelerate the ... ARC Centre of Excellence in Advanced Molecular Imaging ARC Centre of Excellence for Children and Families over the Life Course ... Excellence for Enabling Eco-Efficient Beneficiation of Minerals ARC Centre of Excellence for Innovations in Peptide and Protein ...

https://en.wikipedia.org/wiki/Center_of_excellence

... combining molecular, morphological and behavioural data, gives the following cladogram: On this hypothesis, the molecular data ... To develop, the larvae must be fed both nectar for carbohydrates and pollen for protein. Bumblebees feed nectar to the larvae ... Further, it is necessary, since insect motor nerves generally cannot fire 200 times per second. These types of muscles are ... Molecular Biology and Evolution. 33 (3): 670-678. doi:10.1093/molbev/msv258. PMID 26576851. "†Oligobombus Antropov 2014 (bee ...

https://en.wikipedia.org/wiki/Bumblebee

The SON protein is mainly localised to nuclear speckles and involved in a variety of cellular processes such as transcription, ... The development of gross and fine motor skills, as well as fluent and receptive language skills are shown to be delayed in ... Molecular Cell. 42 (2): 185-198. doi:10.1016/j.molcel.2011.03.014. ISSN 1097-2765. PMC 3137374. PMID 21504830. Khan, I. M.; ... The majority of SON variants found in ZTTK syndrome individuals are localised to exon 3. The SON gene encodes the SON protein, ...

https://en.wikipedia.org/wiki/ZTTK_syndrome

In 2013, the De Koninck team reported the identification of a compound that restored the function of a protein called KCC2, and ... Molecular Pain Award, Association for the Study of Neurons and Diseases 2013: Researcher of the Month, Canadians for Medical ... motor spasticity, stress, anxiety, schizophrenia, and morphine-induced hyperalgesia. Marc Bergeron received a CIHR Brain Star ... Another study, published in the journal Brain in 2013 further highlighted the importance of the KCC2 protein in neuropathic ...

https://en.wikipedia.org/wiki/Yves_De_Koninck

These structural abnormalities in the motor cortex might explain why the hands, requiring great motor dexterity and therefore ... recombination protein A). DCC encodes a receptor for NTN1 (netrin-1), a protein thought to be responsible for axon guidance and ... Currently, clinical diagnosis of CMM disorder has been based on clinical findings or molecular genetic testing. Clinical ... and thereby omission of 28 amino acids from DNAL4 protein. This mutant DNAL4 protein, in turn, could lead to faulty cross- ...

https://en.wikipedia.org/wiki/Congenital_mirror_movement_disorder

March 1999). "A Molecular Study of Euglenoid Phylogeny using Small Subunit rDNA". Journal of Eukaryotic Microbiology. 46 (2): ... However, while Peranema lack a localized photoreceptor, they do possess the light-sensitive protein rhodopsin, and respond to ... "Photo-dynamic Action in the Flagellate Peranema Trichophorum with Special Reference to Motor Response to Light". Chicago ... In 1997, a combined morphological and molecular analysis of certain Euglenoids identified Peranama trichophorum, Euglena ...

https://en.wikipedia.org/wiki/Peranema

Well-known examples of polymers include plastics, DNA and proteins. According to the abstract released by the U.S. Patent & ... The mechanical power is converted into a controlled-cycle hydraulic power to activate a hydraulic motor, which in turn ... other maladies of the eye Gualberto Ruaño is a pioneer in the field of personalized medicine and the inventor of molecular ... "Limited proteolysis of gap junction protein is intrinsic in mammalian lens fiber-cell plasma membranes". Biochemical and ...

https://en.wikipedia.org/wiki/List_of_Puerto_Rican_scientists_and_inventors

... "hnRNP-G promotes exon 7 inclusion of survival motor neuron (SMN) via direct interaction with Htra2-beta1". Human Molecular ... a novel relative of SAM68 that interacts with an RNA-binding protein implicated in spermatogenesis". Human Molecular Genetics. ... and other hnRNP G proteins interact with Tra2beta and affect splicing". Human Molecular Genetics. 9 (5): 685-94. doi:10.1093/ ... "Regulation of alternative splicing by SRrp86 and its interacting proteins". Molecular and Cellular Biology. 23 (21): 7437-47. ...

https://en.wikipedia.org/wiki/RBMX

The sigma-1 receptor (σ1R), one of two sigma receptor subtypes, is a chaperone protein at the endoplasmic reticulum (ER) that ... Su TP, Hayashi T (October 2003). "Understanding the molecular mechanism of sigma-1 receptors: towards a hypothesis that sigma-1 ... June 2015). "A SIGMAR1 splice-site mutation causes distal hereditary motor neuropathy". Neurology. 84 (24): 2430-2437. doi: ... σ1R is targeted by the nsp6 protein of SARS-CoV-2 to inhibit autophagosome formation as a process competing with the ...

https://en.wikipedia.org/wiki/Sigma-1_receptor

MHC-β is a 223 kDa protein composed of 1935 amino acids. MHC-β is a hexameric, asymmetric motor forming the bulk of the thick ... Alpert NR, Brosseau C, Federico A, Krenz M, Robbins J, Warshaw DM (October 2002). "Molecular mechanics of mouse cardiac myosin ... Harris SP, Lyons RG, Bezold KL (March 2011). "In the thick of it: HCM-causing mutations in myosin binding proteins of the thick ... MHC-β is the major protein comprising the thick filament in cardiac muscle and plays a major role in cardiac muscle contraction ...

https://en.wikipedia.org/wiki/MYH7

The production of this reaction might be due to a form of molecular mimicry, where Borrelia avoids being killed by the immune ... Within the tick midgut, the Borrelia's outer surface protein A (OspA) binds to the tick receptor for OspA, known as TROSPA. ... In extreme cases, permanent impairment of motor or sensory function of the lower limbs may occur. In European children, the ... After the bacteria migrate from the midgut to the salivary glands, OspC binds to Salp15, a tick salivary protein that appears ...

https://en.wikipedia.org/wiki/Lyme_disease

The MeCP2 protein plays a pivotal role in regulating brain function. Increased levels of MECP2 protein results in abnormal ... MECP2 duplication syndrome (M2DS) is a rare disease that is characterized by severe intellectual disability and impaired motor ... Van Esch, H. (2011). "MECP2 Duplication Syndrome". Molecular Syndromology. 2 (3-5): 128-136. doi:10.1159/000329580. ISSN 1661- ... The cause of M2DS is a duplication of the MECP2 or Methyl CpG binding protein 2 gene located on the X chromosome (Xq28). ...

https://en.wikipedia.org/wiki/MECP2_duplication_syndrome

... especially the role of abnormal protein aggregates (misfolded proteins) in these diseases. The major goal of his research was ... motor neuron disease, dementia with Lewy bodies (DLB), frontotemporal lobar degeneration (FTLD) and other aging related nervous ... Molecular Basis of Neurological Disorders, the Robarts Institute, London, Ontario, Canada, 2014 Award for Meritorious ... He and his partner, Virginia Man-Yee Lee, MBA, Ph.D., are noted for identifying the roles of three proteins in ...

https://en.wikipedia.org/wiki/John_Q._Trojanowski

Presentation of motor symptoms is variable, but they are usually symmetric, presenting on both sides of the body. Only one of ... Also, DLB is a synucleinopathy, meaning that it is characterized by abnormal deposits of alpha-synuclein protein in the brain. ... Goedert M, Spillantini MG (May 2017). "Propagation of Tau aggregates". Molecular Brain. 10 (1): 18. doi:10.1186/s13041-017-0298 ... Motor symptoms in DLB appear to respond somewhat less to medications used to treat Parkinson's disease, like levodopa, and ...

https://en.wikipedia.org/wiki/Dementia_with_Lewy_bodies

Li MC, Brady JE, DiMaggio CJ, Lusardi AR, Tzong KY, Li G (2012). "Marijuana use and motor vehicle crashes". Epidemiologic ... Rubino T, Parolaro D (April 2008). "Long lasting consequences of cannabis exposure in adolescence". Molecular and Cellular ... changed blood proteins associated with heart disease and stroke. A 2000 study by researchers at Boston's Beth Israel Deaconess ... Cannabinoids produce a "marked depression of motor activity" via activation of neuronal cannabinoid receptors belonging to the ...

https://en.wikipedia.org/wiki/Effects_of_cannabis

Bernstein H, Hopf FA, Michod RE (1987). "The molecular basis of the evolution of sex". Molecular Genetics of Development. Adv. ... Earthworms use, in addition to the digestive proteins, a class of surface active compounds called drilodefensins, which help ... connected to a nerve running along its length to motor neurons and sensory cells in each segment. Large numbers of ... The intestine secretes pepsin to digest proteins, amylase to digest polysaccharides, cellulase to digest cellulose, and lipase ...

https://en.wikipedia.org/wiki/Earthworm

The eukaryotic proteasome recognizes degradable proteins, including damaged proteins for protein quality control purpose or key ... Ikeda K, Akiyama H, Arai T, Ueno H, Tsuchiya K, Kosaka K (Jul 2002). "Morphometrical reappraisal of motor neuron system of ... Gaddis NC, Chertova E, Sheehy AM, Henderson LE, Malim MH (May 2003). "Comprehensive investigation of the molecular defect in ... "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes". ...

https://en.wikipedia.org/wiki/PSMB3

... (GEMIN2), also called survival of motor neuron protein-interacting protein 1 (SIP1), is a protein that ... protein and a specific subset of spliceosomal Sm proteins". Human Molecular Genetics. 9 (13): 1977-1986. doi:10.1093/hmg/9.13. ... "Entrez Gene: SIP1 survival of motor neuron protein interacting protein 1". Mourelatos Z, Dostie J, Paushkin S, Sharma A, ... protein and a specific subset of spliceosomal Sm proteins". Human Molecular Genetics. 9 (13): 1977-1986. doi:10.1093/hmg/9.13. ...

https://en.wikipedia.org/wiki/Gem-associated_protein_2

During transport, translation of oskar is repressed by the RNA-binding protein Bruno, which is in turn released by the binding ... Since 1992, Anne Ephrussi has been a group leader at the European Molecular Biology Laboratory (EMBL). She became the head of ... cytoskeletal polarization and cytoskeletal motors play in RNA localization. Further, the roles of non-canonical RNA binding ... After proper localization, oskar RNA is translated and organizes germ plasm by recruiting other proteins such as Vasa. Her ...

https://en.wikipedia.org/wiki/Anne_Ephrussi

Cross RL (2004). "Molecular motors: turning the ATP motor". Nature. 427 (6973): 407-8. Bibcode:2004Natur.427..407C. doi:10.1038 ... Oster G, Wang H (2003). "Rotary protein motors". Trends Cell Biol. 13 (3): 114-21. doi:10.1016/S0962-8924(03)00004-7. PMID ... Wang H, Oster G (1998). "Energy transduction in the F1 motor of ATP synthase". Nature. 396 (6708): 279-82. Bibcode:1998Natur. ...

https://en.wikipedia.org/wiki/ATP5S

Near weaning, the protein level continues to increase; this may be due to the need for keratin synthesis for hair and spines, ... Over a decade-long period, around one-third of echidna deaths reported to wildlife authorities in Victoria were due to motor ... A, Molecular & Integrative Physiology. 136 (4): 851-865. doi:10.1016/s1095-6433(03)00225-3. PMID 14667849. Augee, Gooden and ... At the moment of birth, the solution is dilute and contains 1.25% fat, 7.85% protein, and 2.85% carbohydrates and minerals. ...

https://en.wikipedia.org/wiki/Short-beaked_echidna

"Kinesin superfamily motor proteins and intracellular transport". Nature Reviews. Molecular Cell Biology. 10 (10): 682-96. doi: ... This allows the movement of the motor proteins along the microtubule or the microtubule moving across the motor proteins. ... including the motor proteins dynein and kinesin, microtubule-severing proteins like katanin, and other proteins important for ... Unlike other microtubule-associated proteins, motor proteins utilize the energy from ATP hydrolysis to generate mechanical work ...

https://en.wikipedia.org/wiki/Microtubule

... Journal ... Molecular basis for RNA polymerase-dependent transcription complex recycling by the helicase-like motor protein HelD. Nature ... Molecular basis for RNA polymerase-dependent transcription complex recycling by the helicase-like motor protein HelD. Nature ...

https://scholars.uow.edu.au/display/publicationse136869

Engineered pendrin protein, an anion transporter and molecular motor. Jie Tang, Jason L. Pecka, Xiaodong Tan, Kirk W. Beisel, ... Engineered pendrin protein, an anion transporter and molecular motor. / Tang, Jie; Pecka, Jason L.; Tan, Xiaodong et al. ... Tang, J, Pecka, JL, Tan, X, Beisel, KW & He, DZZ 2011, Engineered pendrin protein, an anion transporter and molecular motor, ... Engineered pendrin protein, an anion transporter and molecular motor. In: Journal of Biological Chemistry. 2011 ; Vol. 286, No ...

https://creighton.pure.elsevier.com/en/publications/engineered-pendrin-protein-an-anion-transporter-and-molecular-mot

We tethered a 3.4 kDa polyethylene glycol chain at a defined site within the lumen of the transmembrane protein pore formed by ... Accordingly, the modified pore allows detection of a protein analyte at the single-molecule level, facilitating both ... Here we describe a new type of biosensor element for detecting proteins in solution at nanomolar concentrations. ... Davis, A.P. Synthetic molecular motors. Nature 401, 120-121 (1999).. Article CAS PubMed Google Scholar ...

https://www.nature.com/articles/nbt1000_1091?error=cookies_not_supported&code=e34eb59e-6473-4817-97cd-d3c6b4c48cdb

All the latest science news about molecular motor from Phys.org ... Visualisation reveals how a protein hunkers down to conserve ... A new molecular nano-patterning technique reveals that some molecular motors coordinate differently. Jan 22, 2020 ... Research breaks new ground in understanding how a molecular motor generates force. Jan 14, 2021 ...

https://phys.org/tags/molecular+motor/page2.html?deviceType=mobile

Molecular Motors. Molecular Motor Proteins. D06 - Hormones, Hormone Substitutes, and Hormone Antagonists. ...

https://decs.bvs.br/I/rep_i2007.htm

A computer-generated visualization of a kinesin protein has been circulating on the internet for years affixed with ... Vale, Ronald, D. and Milligan, Ronald A. "The Way Things Move: Looking Under the Hood of Molecular Motor Proteins." The Art of ... "Kinesin superfamily motor proteins and intracellular transport." Nature Reviews Molecular Cell Biology . October 2009. ... The kinesin motor protein was a real scene stealer in Inner Life, although it wasnt even in the original treatment for the ...

https://www.snopes.com/fact-check/what-happiness-looks-like/

... and regulate nuclear positioning during their differentiation through recruitment of molecular motor-associated proteins to the ... They interact with the dynein/dynactin complex and multiple kinesin motors, which engage in a "tug-of-war." Adaptor proteins ... One of the initial observations made about satellites was their molecular motor-dependent retrograde and anterograde motility ... They have extensive interactions with centrosome proteins, microtubule-associated proteins, and enzymes such as kinases and ...

https://www.molbiolcell.org/doi/10.1091/mbc.E19-07-0402

A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components. Gorbea C, et al ... General protein information Go to the top of the page Help Preferred Names. zinc finger protein 483. Names. zinc finger protein ... mRNA and Protein(s) * NM_001007169.6 → NP_001007170.1 zinc finger protein 483 isoform b ... mRNA and Protein(s) * XM_047422864.1 → XP_047278820.1 zinc finger protein 483 isoform X2 ...

https://www.ncbi.nlm.nih.gov/gene/158399

... many protein-based molecular motors harness the chemical free energy released by the hydrolysis of ATP in order to perform ... Molecular motor * abstract: Molecular motors are biological molecular machines that are the essential agents of movement in ... In this paper, we study coupled diffusion processes with smooth coefficients, which model the system of the molecular motor. ... Through the analytical calculation and numerical simulation, additive white noise cant induce molecular motor to produce ...

http://dict.youdao.com/w/molecular_motor/

Proteins function by folding into myriad, precise 3D structures. Image: Mohammed AlQuraishi ... efforts to illuminate protein structures are central to all of molecular biology-and in particular, therapeutic science and the ... act as molecular factories, transporters and motors; serve as both signal and receiver for cellular communications; and much ... "A protein starts off as an unstructured string that has to take on a 3D shape, and the possible sets of shapes that a string ...

https://hms.harvard.edu/news/folding-revolution

Example ranges from the vehicular traffic on highways to the transport at the molecular scale by motor proteins. One common ...

https://www.imsc.res.in/cgi-bin/CalciumShyam/Calcium40.pl?CalendarName=MathematicsEvents&Source=IMScWebinar&Date=2021%2F4%2F26&Op=PopupWindow&ID=229&DoneURL=Calcium40.pl%3FCalendarName%3DMathematicsEvents%26Op%3DShowIt%26Amount%3DMonth%26NavType%3DAbsolute%26Type%3DBlock%26Date%3D2021%252F4%252F1&Amount=Month&NavType=Absolute&Type=Block

In networks-based biocomputation,[6] self-propelled biological agents, such as molecular motor proteins or bacteria, explore a ... For instance, in the system described by Nicolau et al.,[6] mobile molecular motor filaments are detected at the "exits" of a ... A ribosome is a biological machine that uses protein dynamics on nanoscales to translate RNA into proteins ... "Parallel computation with molecular-motor-propelled agents in nanofabricated networks". Proceedings of the National Academy of ...

https://en.wikipedia.org/wiki/Biological_computing

2020). Unidirectional Rotating Molecular Motors Dynamically Interact with Adsorbed Proteins to Direct the Fate of Mesenchymal ... Kesarwani, P., Murali, A. K., Al-Khami, A. A., and Mehrotra, S. (2013). Redox Regulation of T-Cell Function: From Molecular ... They can activate nuclear factor κB (NFκB) and p38 mitogen-activated protein kinase (MAPK) signaling pathways and promote the ... For instance, a nanocomposite loaded with chlorin e6 (as a sonosensitizer) induced ICD via receptor-interacting protein kinase ...

https://www.frontiersin.org/articles/10.3389/fbioe.2021.784612/full

... now he is tackling one of his most ambitious subjects to date representing the varied and complex behavior of the motor protein ... For almost 40 years, he has been creating dynamic computer models of proteins, nucleic acids and other macromolecules and ... representing the varied and complex behavior of the motor protein, myosin. This protein drives a number of critical cell ... Coming to a screen later this century: Molecular portrait of motor movement. ...

https://news.stanford.edu/news/2006/march15/med-myosin-031506.html

Molecular Motor Proteins Medicine & Life Sciences 68% * In Vitro Techniques Medicine & Life Sciences 37% ... protein synthesis, motility, etc.). Here, we describe methods to evaluate spatial and temporal protein production in neural ... protein synthesis, motility, etc.). Here, we describe methods to evaluate spatial and temporal protein production in neural ... protein synthesis, motility, etc.). Here, we describe methods to evaluate spatial and temporal protein production in neural ...

https://asu.pure.elsevier.com/en/publications/evaluating-the-spatial-and-temporal-protein-production-in-neural--2

3D printed protein-based robotic structures actuated by molecular motor assemblies. Nature Materials 21 (6), S. 703 - 709 (2022 ... Jia, H.; Kai, L.; Heymann, M.; Garcia-Soriano, D.; Härtel, T.; Schwille, P.: Light-Induced Printing of Protein Structures on ... Jia, H.; Heymann, M.; Härtel, T.; Kai, L.; Schwille, P.: Temperature-sensitive protein expression in protocells. Chemical ... Litschel, T.; Ramm, B.; Maas, R.; Heymann, M.; Schwille, P.: Beating vesicles: Encapsulated protein oscillations cause dynamic ...

https://www.biochem.mpg.de/publication-search/2247?person=%2Fpersons%2Fresource%2Fpersons197087

The Yerbury lab is dedicated to understanding the molecular mechanisms underpinning Motor Neurone Disease (MND), with a ... Protein-aggregation related diseases. In a healthy cell, the production and degradation of protein are integrated with ... Work currently being undertaken in this laboratory extends from molecular biology-based techniques to recombinant protein ... Parkinsons disease and Motor Neurone Disease (MND). Research in the Ecroyd lab focuses on the role of molecular chaperone ...

https://www.uow.edu.au/research-and-innovation/our-research/research-institutes-and-facilities/molecular-horizons/themes-disciplines/protein-aggregation-related-diseases/

Molecular distributions, reaction kinetics, enzyme kinetics. Bioenergetics, energy transduction, and motor proteins. ... Experimental techniques in mammalian molecular biology and cellular immunology. Molecular techniques covered include PCR and ... MCB 153: Molecular Therapeutics (4 units; Syllabus). Prerequisites: Biology 1A, MCB 102 or MCB C100A. The overarching goal of ... MCB 170L: Molecular and Cell Biology Laboratory (4 units; Syllabus) Prerequisites: MCB 102 or c100A. This laboratory class is ...

http://mcb.berkeley.edu/undergrad/courses/courses/ud-courses

... or metabolic proteins). These proteins will provide the framework for discussion of such concepts as domains, motifs, molecular ... How has the basic understanding of the smallest molecular motor in the world, ATP synthase, changed our understanding of ... If the basic tenants of eukaryotic molecular biology have followed the prokaryotic paradigm-- DNA makes RNA makes protein-- ... 251 Molecular Genetics. (Offered as BIOL 251 and BCBP 281) A study of the molecular mechanisms underlying the transmission and ...

https://www.amherst.edu/academiclife/departments/biology/courses/1415F?display=curriculum

Human eggs are missing an important protein, which acts as a molecular motor, as researchers have found out. Their findings ... As response to a heat-shock, for instance, cells start the production of new proteins to help damaged proteins. But at the same ... But the scientists wondered how the protein complex comes into action. The team found that proteins produced at the time of the ... "Here it binds to genes in the same location as the NELF protein complex does. Therefore, p38α is the messenger that relays the ...

https://www.mpg.de/12701881/slow-down-of-gene-transcription

I teach an undergraduate course on Molecular Motors in Biology. This course grew out of an interest of mine in the dynamics of ... proteins. Check out the course web page which has interactive applets showing how polymers grow and molecular motors move.. I ... and molecular sensing, as for identifying molecular species from a single molecule. ... Ramasamy, Uma Shantini; Lichter, Seth H; Martini, Ashlie, Effect of Molecular-Scale Features on the Polymer Coil Size of Model ...

https://www.mccormick.northwestern.edu/research-faculty/directory/profiles/lichter-seth.html

... he is focusing on the de novo design of protein rotary motors, in which symmetric energy minima along an interface between ... design rules to rationally install biochemical energy driven dynamic and mechanical behavior within de novo protein ... These transmembrane motors represent one of the more accessible possibilities for a useful application of molecular machines. ... Lessons can be learned from the already existing examples of protein motors - one such example is the flagellum, which uses ...

https://foresight.org/summary/alexis-courbet-towards-computational-design-of-self-assembling-genetically-encodable-nanomachines/

Intracellular transport is an essential process for cellular functions and is driven by molecular motors. ... What is the difference between an intracellular and extracellular protein?. Intracellular proteins: Some proteins in the ... HSC70 helps these proteins to enter the lysosome and be degraded by proteolytic enzymes. Extracellular protein: enters cells ... How do coiled-coil proteins support intra-Golgi transport?. *What is the role of Ceramide transport protein in lipid transport? ...

https://www.evanewyork.net/what-are-the-three-mechanisms-of-protein-transport/

We will then consider how polymerisation of protein filaments and action of molecular motors can generate forces in biological ... We will introduce essential biopolymers including DNA and proteins. We will provide an introduction to systems of interest, for ... Using these physical principles we will explore molecules essential to life, such as proteins and DNA, and materials key to ... Statistical mechanics models will enable us to predict bulk properties from molecular parameters. We will introduce ...

https://www.sheffield.ac.uk/undergraduate/courses/2023/physics-mphys

One can study the denaturation of DNA or protein folding and RNA within this framework. For the latter, the classification of ... of proteins; we have performed a statistical study of known RNA structures in data bases and have concluded that RNA strands ... Amyloid fibrils are misfolded aggregates of proteins that are responsible of major diseases including diabetes, Alzheimer and ... formulation of this dynamics was found and applied to sampling the paths between folded and unfolded states of a protein. It ...

https://ipht.cea.fr/Phocea/Vie_des_labos/Ast/ast_visu.php?id_ast=873

Roche Molecular Biochemicals PCR reagents were used. The cortTA.su primer was used as the sense upper primer to amplify both ... Protein Interaction Mapping. A glutathione S-transferase (GST) fusion protein of the SH3 domain of cortactin was isolated as ... Proteins that bound were fractionated by SDS-PAGE and were analyzed by immunoblotting. A GST fusion protein containing the SH3 ... 1994). Further, a recent study has suggested that the actin-binding protein, profilin, interacts with a host of protein ...

https://rupress.org/jcb/article/151/1/187/54251/Regulated-Interactions-between-Dynamin-and-the

Mutations in the microtubule (MT)-binding protein doublecortin (DCX) or in the MT-based molecular motor dynein result in ... Such polarity domains can be cortical enrichment of molecular motors such as Dynein (Grill et al., 2001; Kotak and Gönczy, 2013 ... et al.[…] Such polarity domains can be cortical enrichment of molecular motors such as Dynein (Grill et al., 2001; Kotak and ... Previous work showed an increased binding of the adaptor protein C-Jun-amino-terminal kinase-interacting protein 3 (JIP3) to ...

https://elifesciences.org/articles/75639

Ann Gauger discusses a central argument used by evolutionary biologists to say its simple to get new proteins. ... where her work was on the molecular motor kinesin.. Follow Ann. Profile. Tags. Topics. __edited __repeat Intelligent Design ... Gauger: Is It Easy to Get A New Protein? Ann Gauger. March 13, 2017. Episode. 995. Guest. Ann Gauger. Duration. 00:15:23. ... Dover Michael Behe Molecular Machines Naturalism Science and faith Jerry Coyne human exceptionalism philosophy of science ...

https://idthefuture.com/995/

Protein crystallography, molecular motors, cellular transport mechanisms, enzyme mechanisms Google:. "Rukman De Silva". Mean ... Molecular Microbiology. 83: 457-70. De Silva RS, Kovacikova G, Lin W, et al. (2007) Crystal structure of the Vibrio cholerae ... quorum-sensing regulatory protein HapR. Journal of Bacteriology. 189: 5683-91. De Silva RS, Kovacikova G, Lin W, et al. (2005) ...

https://academictree.org/chemistry/peopleinfo.php?pid=146590

Molecular characterization of an extended binding site for coagulation factor Va in the positive exosite of activated protein C ... n = 5. (B) SOD1G93A and mSOD1 protein levels, determined by immunoblot analysis of motor neuron cell lysates from SOD1G93A mice ... Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia ... of mSOD1 protein, in laser-captured motor neurons from EPCRδ/δ and EPCR+/+ mice treated with saline or 100 μg/kg/d 5A-APC i.p. ...

https://www.jci.org/articles/view/38476

We then describe the progress in the identification of the satellite interactome, which have paved the way to a molecular understanding of their mechanism of action and assembly mechanisms. (molbiolcell.org)
Given the nature of these biochemical systems to be regulated through many different mechanisms, one can engineer a chemical pathway comprising a set of molecular components that react to produce one particular product under one set of specific chemical conditions and another particular product under another set of conditions. (wikipedia.org)
Our researchers investigate the molecule mechanisms of protein aggregation and work on the next generation of therapies against these diseases. (edu.au)
The Yerbury lab is dedicated to understanding the molecular mechanisms underpinning Motor Neurone Disease (MND), with a particular focus on protein misfolding and protein aggregation. (edu.au)
What are the three mechanisms of protein transport? (evanewyork.net)
Some of these transport mechanisms require the input of energy and use of a transmembrane protein, whereas other mechanisms do not incorporate secondary molecules. (evanewyork.net)
While UCDs are a widespread phenomenon in metazoan embryogenesis, the molecular and cellular mechanisms underlying UCD are still being debated. (elifesciences.org)
Focusing on motor learning in the rat, J. Francis and W. Song discuss plasticity mechanisms on the behavioral, neurophysiological, and synaptic levels. (hindawi.com)
Relating molecular plasticity with behavioral changes, these results shed new light on circuit mechanisms of motor learning. (hindawi.com)
Cells normally strive to ensure that proteins are correctly folded by using powerful and sophisticated mechanisms to maintain protein homeostasis under adverse conditions. (cam.ac.uk)
Munich-based scientists have now investigated the molecular mechanisms in the cytoskeleton necessary for this and revealed potential evolutionary pa. (lmu.de)
That is why the research team used zebrafish and clawed frogs for experimental investigations in Ökten's laboratory to examine the origin and the molecular mechanisms of interaction between the microtubule network and the actin network. (lmu.de)
Here the motor proteins which move the pigments organelles are subject to different regulatory mechanisms, and there is no interaction between the different cytoskeleton networks", says Ökten. (lmu.de)
Drew AP, Blair IP, Nicholson GA. Molecular genetics and mechanisms of disease in distal hereditary motor neuropathies: insights directing future genetic studies. (medlineplus.gov)
The molecular and neural mechanisms underpinning eccentric contractions differ from those of concentric and isometric contractions and remain less understood. (nih.gov)
Postulated mechanisms include a strain-induced modulation of actin-myosin interactions at the level of the cross-bridge, the activation of the structural protein titin, and the winding of titin on actin. (nih.gov)
The molecular mechanisms of motor neuron death and nerve degeneration arelargely unknown and there are no effective therapies to increase the functional recovery after BRPA.Aim: To detect the early pathway changes in spinal cord tissues after brachial plexus root avulsion.Methods A mouse brachial plexus avulsion and re-implantation model was constructed, and the C5-C7segments of the spinal cords were dissected three days after the surgery. (who.int)
Taurursodiol recovers mitochondrial bioenergetics deficits through several mechanisms, including by preventing translocation of the Bax protein into the mitochondrial membrane, thus reducing mitochondrial permeability and increasing the cell's apoptotic threshold. (medscape.com)
I lead the Chris Miller lab, where our research aims to better understad the molecular mechanisms that underlie neuronal cell death in neurodegenerative diseases. (kcl.ac.uk)
Intervertebral Disc Aging, Degeneration, and Associated Potential Molecular Mechanisms. (juniperpublishers.com)

Because a protein's shape determines its function and the extent of its dysfunction in disease, efforts to illuminate protein structures are central to all of molecular biology-and in particular, therapeutic science and the development of lifesaving and life-altering medicines. (harvard.edu)
For almost 40 years, Levitt, professor of structural biology, has been merging the worlds of biology and computers to create dynamic models of proteins, nucleic acids and other macromolecules. (stanford.edu)
Work currently being undertaken in this laboratory extends from molecular biology-based techniques to recombinant protein expression and purification, in vitro biochemical assays of chaperone protein activity, to mammalian cell culture and the study of protein expression and modification in animal tissues. (edu.au)
Utilising a broad array of methods ranging from the fields of biophysics, biochemistry, and cell and molecular biology, we study the basic biological processes that lead to protein aggregation, with the aim of identifying and developing novel therapeutic strategies for the treatment of MND. (edu.au)
The course is designed for majors in the biochemistry and molecular biology, genetics and development, or immunology emphases. (berkeley.edu)
Prerequisite courses will have introduced students to the concepts of cells, the central dogma of molecular biology, and gene regulation. (berkeley.edu)
Molecular biology and biochemical processes of prokaryotic and eukaryotic cells and their viruses. (berkeley.edu)
Experimental techniques of biochemistry and molecular biology, designed to accompany the lectures in 100B and 110. (berkeley.edu)
I teach an undergraduate course on Molecular Motors in Biology. (northwestern.edu)
By Hannah Waters Andrew Carter: Dynein Trailblazer Nick Morrish Group Leader, Laboratory of Molecular Biology, Medical Research Council. (the-scientist.com)
Group Leader, Laboratory of Molecular Biology, Medical Research Council. (the-scientist.com)
Dr. Chen was able to do this, thereby connecting the disease pathology with the molecular biology," says Schubert. (salk.edu)
After a series of renovations and modifications, the fall semester of introductory biology (Biol18b) is now an 11 week project-based lab course focused on Molecular and Structural Biology. (brandeis.edu)
Coleen Murphy from the Dept of Molecular Biology at Princeton will tell us about " Slowing the Ticking Clock: What we can learn about aging and memory from C. elegans " at the first Ruth Ann and Nathan Perlmutter Science Forum on Wednesday, March 9 at 4:00 pm in Gerstenzang 121. (brandeis.edu)
The biological sciences, or the life sciences, encompass a broad spectrum of subjects from molecular biology to ecology as well as such disciplines as biochemistry, biophysics, genetics and physiology. (brocku.ca)
We develop new tools in structural biology, namely MicroED as a new method for cryo EM, to facilitate the study of such membrane proteins to atomic resolution from vanishingly small crystals. (janelia.org)
Currently, with the application of molecular biology resources in human identification, it became possible to identify a person even without physical ante-mortem data or with deteriorated biological material in negligible amounts, which are actually relatively common conditions in forensic analyses 7,12,16,19 . (bvsalud.org)

The group are also developing new single-molecule approaches so that, for the first time, we can see and characterise the interactions between heat-shock proteins and aggregation-prone proteins. (edu.au)
Heat shock proteins block signals that lead to programmed cell death. (medlineplus.gov)
Heat shock proteins also appear to play a role in the tensing of muscle fibers (muscle contraction). (medlineplus.gov)
Mutations of small heat shock proteins and human congenital diseases. (medlineplus.gov)
Dierick I, Irobi J, De Jonghe P, Timmerman V. Small heat shock proteins in inherited peripheral neuropathies. (medlineplus.gov)
Sodium phenylbutyrate is a histone deacetylase inhibitor shown to upregulate heat-shock proteins and act as a small molecular chaperone, thereby ameliorating toxicity from endoplasmic reticulum stress. (medscape.com)
Our previous studies suggested that mammalian heat shock proteins might be able to play similar roles in both diseases. (bmj.com)

The motions of muscles as well as much smaller intracellular cargoes are driven by molecular motors that move unidirectionally along protein polymers (actin or microtubules). (snopes.com)
Of the 13 known types of myosin, Levitt is focusing on myosin II or conventional myosin, which possesses an arm-like ability to reach out and pull itself forward along filaments of actin, a major protein component of the cell cytoskeleton. (stanford.edu)
Biomolecular engineering techniques enabled demonstration of enhanced stability of actin filaments in the presence of tropomyosin, a family of muscle proteins that regulates the interaction between actin and myosin. (europa.eu)
All cells of higher organisms are permeated by a cytoskeleton that essentially consists of actin filaments and small protein tubes called microtubules. (lmu.de)
For this purpose they are actively transported by molecular motors on the microtubules and actin filaments. (lmu.de)
Myosin transports its freight via the actin network, but the adapter protein also interacts with the microtubules and can redirect the transport on this network. (lmu.de)
The scientists found out that the mouse adapter protein as well as the clawed frog adapter protein has a specific domain which enables the switching between the transport of actin and microtubules. (lmu.de)
Moreover, the experimental results showed that the environmental signals which bring about the redistribution of pigment organelles in the organism of clawed frogs are associated with a change of probability with which the individual motor proteins from the actin filaments switch to the microtubule filaments. (lmu.de)
The myosin S1 heads (two per myosin protein) include binding sites for ATP and for the thin filament protein actin. (biologists.com)
MYOVA encodes myosin Va, an actin-based motor protein important for the intracellular transport of organelles in melanocyte and neuronal cells. (cdc.gov)

It does this by releasing the chemical energy stored in adenosine triphosphate (ATP), the molecular fuel for most cellular reactions, and converting it into mechanical energy. (stanford.edu)
However, moving into a 3-D system presents complications of assessing spatial and temporal alterations in cellular behavior (e.g., protein synthesis, motility, etc. (elsevier.com)
This course for upper division and graduate students will explore the molecular and cellular basis of microbial pathogenesis. (berkeley.edu)
Notably, the research group found that key features of SITA such as protein ubiquitination and gene shutdown also occur in a cellular model of Huntington disease. (mpg.de)
Intracellular transport is an essential process for cellular functions and is driven by molecular motors. (evanewyork.net)
Scientists are developing diagnostic devices based on miniature cellular motors. (europa.eu)
Scientists working on the EU-funded project 'Molecular motor-based nanodevices' (MONAD) are exploiting these ubiquitous cellular nanomachines in systems for diagnostics, drug discovery and basic biomedical research. (europa.eu)
A large body of research over the last decades has drastically increased our understanding of the molecular and cellular processes underlying learning, most notably through a detailed investigation of synaptic plasticity. (hindawi.com)
However, with age, the cellular defence systems against misfolded proteins seem to gradually fail, leading to the accumulation of misfolded proteins, with devastating consequences for cells and organisms. (cam.ac.uk)
Research led by Anne Bertolotti, in the LMB's Neurobiology Division, has identified a novel, selective and safe pharmacological approach to boost a natural cellular defense against misfolded proteins and thus safely preventing protein misfolding diseases in mice. (cam.ac.uk)
This small molecule boosts the natural cellular defence systems against damaged proteins and prevents them from accumulating and becoming harmful. (cam.ac.uk)
Specialized cellular fonctions of human ribosomal proteins beyond the ribosome. (usherbrooke.ca)
Ackerley S, James PA, Kalli A, French S, Davies KE, Talbot K. A mutation in the small heat-shock protein HSPB1 leading to distal hereditary motor neuronopathy disrupts neurofilament assembly and the axonal transport of specific cellular cargoes. (medlineplus.gov)
Ischemic stroke is followed by a series of events, such as inflammation, increased oxidative stress, and the spread of damage, that can lead to mitochondrial damage, protein degradation, and cellular apoptosis. (shefayekhatam.ir)
The similarity of carbon nanotubes to microtubules suggests a potential to interact with cellular biomolecules, such as the mitotic spindle, as well as the motor proteins that separate the chromosomes during cell division. (cdc.gov)

Molecular motors are biological molecular machines that are the essential agents of movement in living organisms. (youdao.com)
Nearly every fundamental biological process necessary for life is carried out by proteins. (harvard.edu)
Biological computers use biologically derived molecules - such as DNA and proteins - to perform digital or real computations . (wikipedia.org)
In networks-based biocomputation, [6] self-propelled biological agents, such as molecular motor proteins or bacteria, explore a microscopic network that encodes a mathematical problem of interest. (wikipedia.org)
A comprehensive survey of the fundamentals of biological chemistry, including the properties of intermediary metabolites, the structure and function of biological macromolecules, the logic of metabolic pathways (both degradative and biosynthetic) and the molecular basis of genetics and gene expression. (berkeley.edu)
Nanostructures are present everywhere in biological systems, from proteins to cytoskeletons and from molecular motors to nanopatterned leaves, and have specific structural or more complex functions. (wur.nl)
One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health. (cam.ac.uk)
Dr. Zeynep Ökten from the Chair of Molecular Biophysics at the Technical University of Munich (TUM)and Erwin Frey, Professor of Statistical and Biological Physics at the Ludwig-Maximilian-University of Munich - with their teams - have now for the first time identified a molecular mechanism by the example of change of color among animals which explains the communication between both network systems, and revealed potential evolutionary paths. (lmu.de)
Biological systems, from proteins to living cells and organisms, obey physical principles. (tum.de)
A recent study of a protein called MOCA (Modifier of Cell Adhesion), carried out at the Salk Institute for Biological Studies, provides new clues to the answers of these fundamental questions. (salk.edu)
It is an absolutely vital component of the selenium-dependent proteins that have several biological functions in human health, including an antioxidant function. (pharmanord.com)
8] Polymers range from familiar synthetic plastics such as polystyrene to natural biopolymers such as DNA and proteins that are fundamental to biological structure and function. (name.tr)

Dynein transports a wide variety of molecules along microtubules within the cell, is involved in mitosis, and seems to function differently than the well-studied molecular motor proteins kinesin and myosin. (the-scientist.com)

We questioned whether it was possible to create a chimeric pendrin protein with motor capability by integrating this motility motif from prestin. (elsevier.com)
Non-linear capacitance and somatic motility, two hallmarks representing prestin function, were measured from chimeric pendrin-transfected human embryonic kidney 293 cells using the voltage clamp technique and photodiode-based displacement measurement system.Weshowed that this 14-amino acid substitution from prestin was able to confer pendrin with voltage-dependent motor capability despite the amino acid sequence disparity between pendrin and prestin. (elsevier.com)
Studies of nanostructures with embedded molecular motors facilitated optimisation of control of motility on active surfaces. (europa.eu)
Focusing on applications to high-throughput drug screening of molecular activity, the team continued to identify motor binding sites that could be potent activators of motor proteins and have delivered several versions of a motility assay-based drug discovery device (based on activation leading to motion). (europa.eu)
Thus, we propose that dynein is largely inactive in the cytoplasm and that a variety of adapter proteins activate processive motility by linking dynactin to dynein only when the motor is bound to its proper cargo. (harvard.edu)
In addition, they appear to be involved in activities such as cell movement (motility), stabilizing the cell's structural framework (the cytoskeleton), folding and stabilizing newly produced proteins, and repairing damaged proteins. (medlineplus.gov)

Soft Matter and Biophysics: cytoskeleton, protein-membrane interactions, molecular motors, aggregation processes in disordered and out-of-equilibrium systems. (u-psud.fr)

The molecular mechanism that facilitates motor function appeared to be the same as prestin because the motor activity depended on the concentration of intracellular chloride and was blocked by salicylate treatment. (elsevier.com)
Do intracellular membranes contain transport proteins? (evanewyork.net)
Intracellular membrane traffic depends on transport vesicles and tubules, which shuttle proteins and lipids between compartments. (evanewyork.net)
What is an intracellular protein? (evanewyork.net)
Intracellular proteins are synthesized on cytoplasmic free ribosomes and do not need to be transported outside the cell membrane to function in cells. (evanewyork.net)
What is the difference between an intracellular and extracellular protein? (evanewyork.net)
Intracellular proteins: Some proteins in the cytosol contain a KFERQ signal at the N-terminus, which can be recognized by HSC70. (evanewyork.net)
What is the general protein apparatus used for intracellular transport? (evanewyork.net)
Recent advances have uncovered the general protein apparatus used by all eukaryotes for intracellular transport, including secretion and endocytosis, and for triggered exocytosis of hormones and neurotransmitters. (evanewyork.net)
Cytoplasmic dynein is a molecular motor that transports a large variety of cargoes (e.g., organelles, messenger RNAs, and viruses) along microtubules over long intracellular distances. (harvard.edu)
Individually, neurodegeneration in ALS might result from a complex interaction of glutamate excitotoxicity, the genesis of free radicals, SOD1 enzymes, disruption of axonal transport processes through aggregation of neurofilament intracellular accumulates, cytoplasmic protein accumulates, combined with mitochondrial dysfunction. (medacess.com)
The formation of intracellular amyloid-like inclusions by mutant proteins is a feature of two groups of codon reiteration diseases, for which there are currently no treatments. (bmj.com)
Intracellular amyloid-like inclusions formed by mutant proteins result from polyglutamine expansions in Huntington's disease (HD) and polyalanine expansions in polyadenine binding protein 2 (PABP2) in oculopharyngeal muscular dystrophy (OPMD). (bmj.com)

This is what happiness really looks like: Molecules of the protein myosin drag a ball of endorphins along an active filament into the inner part of the brain's parietal cortex, which produces feelings of happiness. (snopes.com)
Composed of long chains of amino acids, proteins perform these myriad tasks by folding themselves into precise 3D structures that govern how they interact with other molecules. (harvard.edu)
Time-reversible processes include the dynamics of clusters of interacting particles, conformal changes in molecules, and protein folding, while time-irreversible ones are exemplified e.g. by walks of molecular motors. (warwick.ac.uk)
Molecular profiling is the detection of specific genes, proteins, or other molecules in a tumor. (abta.org)

They interact with the dynein/dynactin complex and multiple kinesin motors, which engage in a "tug-of-war. (molbiolcell.org)
The dynactin protein complex is important for dynein activity in vivo, but its precise role has been unclear. (harvard.edu)
However, when dynein formed a complex with dynactin and one of four different cargo-specific adapter proteins, the motor became ultraprocessive, moving for distances similar to those of native cargoes in living cells. (harvard.edu)
dMiro T25N accumulated mitochondria in the soma of larval motor and sensory neurons, and prevented their kinesin-dependent and dynein-dependent distribution into axons and dendrites, respectively. (sdbonline.org)
In polarized cells, such as neurons, mitochondrial mobility and transport require the regulation of kinesin and dynein by two adaptor proteins, Milton and Miro . (sdbonline.org)
Recent, studies have found that Dynein heavy chain 64C (Dhc64C) is the primary motor protein for both anterograde and retrograde transport of mitochondria in the Drosophila bristle. (sdbonline.org)
This study revealed that a molecular lesion in the Dhc64C allele that reduced bristle mitochondrial velocity generated a variant that acts as a "slow" dynein in a MT gliding assay, indicative of dynein directly regulating mitochondrial transport. (sdbonline.org)
After a "fateful beer" with Vale in 2003, Carter headed to his UCSF lab to study the motor protein dynein, which comprises around a whopping 13,500 amino acids in yeast and had yet to be crystallized. (the-scientist.com)
Dynein is a lovely motor," says Carter. (the-scientist.com)
But to study this massive protein, he had to develop a way to systematically cleave off nonessential parts, leaving a smaller molecule to manipulate, and a new way to crystallize large quantities of the protein, growing 75 liters of dynein-producing yeast at a time. (the-scientist.com)
Since developing the new methods, he's solved the structures of two domains of dynein: the microtubule binding domain, 2 which determines the molecule's directionality, and the motor domain, 3 which converts ATP into mechanical energy for directional movement. (the-scientist.com)
and DYNEIN motor families). (bvsalud.org)

BACKGROUND: Data on combining molecular therapies that increase survival motor neuron protein for spinal muscular atrophy type 1 (SMA1) is lacking. (luriechildrens.org)

Here it binds to genes in the same location as the NELF protein complex does. (mpg.de)
Using cultured cells and mice as a model organism, Anne's group have found a small molecule, named Sephin1 (a selective inhibitor of a holophosphatase) which selectively binds and inhibits PPP1R15A, a regulatory subunit of the protein phosphatase PP1, to safely prolong the benefit of a phospho-signaling pathway and prevent the motor, histological and molecular defects of two, otherwise unrelated diseases in mice, Charcot-Marie-Tooth 1B and amyotrophic lateral sclerosis. (cam.ac.uk)
In higher eukaryotes, the mitochondrial GTPase Miro binds Milton /TRAK adaptor proteins linking microtubule motors to mitochondria. (sdbonline.org)
MOCA was initially identified as a protein that binds to presenilin, a molecule that when mutated causes familial Alzheimer's disease. (salk.edu)

In mice, for example, scientists found an adapter protein that regulates this redirection. (lmu.de)
Which network is preferred is controlled by a chemical modification to a specific binding site of the adapter protein. (lmu.de)
Fish and amphibians also have a protein corresponding to the mammalian adapter. (lmu.de)

Adaptor proteins mediate the interaction between motors and satellites. (molbiolcell.org)
Intrinsic cell microtubule (MT) polarity, together with molecular motors and adaptor proteins, determines mitochondrial polarized targeting and MT-dependent transport. (sdbonline.org)
Neuroinflammatory markers, such as ionized calcium binding adaptor molecule 1 (Iba-1), glial fibrillary acidic protein (GFAP), gp91phox and inducible nitric oxide synthase (iNOS), were measured in the nigrostriatal system. (springer.com)

In mammalian cell based models of both polyglutamine and polyalanine diseases, the mutant proteins are much more prone to aggregate formation than their wild-type counterparts and cause significantly more cell death. (bmj.com)

and protein synthesis by ribosomes. (ucsc.edu)
Ribosomes are molecular machines that synthesize proteins. (khanacademy.org)
Proteins Proteins Linear polypeptides that are synthesized on ribosomes and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. (lecturio.com)

They have extensive interactions with centrosome proteins, microtubule-associated proteins, and enzymes such as kinases and ubiquitin ligases. (molbiolcell.org)
HSC70 helps these proteins to enter the lysosome and be degraded by proteolytic enzymes. (evanewyork.net)
Enzymes are proteins that help chemical reactions occur at a faster rate by lowering the energy needed for the reactions. (web.app)
Restriction enzymes are special proteins produced by bacteria to prevent or restrict invasion by foreign dna such as from viruses. (web.app)
One of the most important functions of proteins in living cells is to act as enzymes. (web.app)
Liver function enzymes, aspartate aminotransferase, and alanine aminotransferase activities including total cholesterol, total protein, albumin, and globulin were not changed by BV supplementation. (blogspot.com)

An efficient strategy for small-scale screening and production of archaeal membrane transport proteins in Escherichia coli. (ibs.fr)

Variants of the elongator protein 3 (ELP3) gene are associated with motor neuron degeneration. (cdc.gov)
The axonal degeneration was caused by the accumulation of protein aggregates. (salk.edu)
After documenting the sequence of physiological and behavioral events that characterize the axon degeneration, Chen then sought to piece together the molecular pathway behind it, starting with MOCA and connecting findings from disparate studies that previously had identified parts of the pathway. (salk.edu)
Background Brachial plexus root avulsion (BPRA) can cause motor neuron death, nerve degeneration andupper limb motor dysfunction. (who.int)
This disorder is portrayed by the degeneration of motor neurons that take place in the spinal cord and brain, resulting in the muscle motor paralysis in the next stages of the condition. (medacess.com)
Oral BCAAs have been examined as a treatment for neurological diseases such as mania, motor malfunction, lateral sclerosis, and spinocerebral degeneration. (pursuitofresearch.org)

The Ecroyd research focus is in the field of protein homeostasis (proteostasis), an important area of research as disturbances in proteostasis can lead to protein aggregation (i.e. the clumping of proteins into large deposits), a pathological hallmark of many human diseases, including Alzheimer's disease, Parkinson's disease and Motor Neurone Disease (MND). (edu.au)
Our laboratory studies the structures of membrane proteins important in homeostasis and signaling. (janelia.org)

Accordingly, the modified pore allows detection of a protein analyte at the single-molecule level, facilitating both quantification and identification through a distinctive current signature. (nature.com)
The original plan was to omit the motor protein in the vesicle shots, but when I saw [another researcher's animation of the molecule] I secretly went ahead and modeled one of my own, animated a walk cycle for it, and added it into the vesicle shot. (snopes.com)
By representing the behavior of a single molecule, Levitt's model will offer an up-close view of the force-generating agent underlying all motor movement. (stanford.edu)
Our patent has applications to chemical separation, such as desalination, molecular-scale deposition, such as for quantum dots, and molecular sensing, as for identifying molecular species from a single molecule. (northwestern.edu)
Alexis's research proposes to investigate computational design rules to rationally install biochemical energy driven dynamic and mechanical behavior within de novo protein nanostructures, by tailoring the energy landscape to capture favorable thermal fluctuations allowing to perform work (i.e. rationally designing a Brownian ratchet mechanism using energy from the catalysis of a biologically orthogonal small molecule to break symmetry). (foresight.org)
As a proof of concept, he is focusing on the de novo design of protein rotary motors, in which symmetric energy minima along an interface between multiple components couples rotation to a catalytic event, thereby converting the biochemical energy of a fuel molecule into work. (foresight.org)
With each step, the motor molecule releases one portion of the microtubule and grips a second site farther long the filament. (fsu.edu)
Innovative and flexible tools for protein purification and molecule binding studies. (usherbrooke.ca)
Ensemble and single-molecule spectroscopy demonstrates that both emission and absorption of peridinin-chlorophyll-protein photosynthetic antennae can be largely enhanced through plasmonic interactions. (cipsm.de)

Cytoskeleton offers several reagents for live-cell research including fluorescent proteins, cell permeable protein activators and inhibitors, as well as our recent addition of live cell imaging probes. (cytoskeleton.com)

The most advanced algorithms calculate protein structure by running on supercomputers-or crowd-sourced computing power in the case of projects such as [email protected] and [email protected] simulate the complex physics of amino acid interactions through brute force. (harvard.edu)
Tudor domains are found in many organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. (biologists.com)

This organization gives the structure polarity , with only the alpha -tubulin proteins exposed at one end and only beta -tubulin proteins at the other. (fsu.edu)

Alexis is working on designing atomically precise machines using proteins as structural and mechanical elements. (foresight.org)
Coiled-coil proteins of the golgin family have been implicated in intra-Golgi transport through tethering events in membrane fusion and as structural supports for the Golgi complex. (evanewyork.net)
In addition to their structural support role, microtubules also serve as a highway system along which organelles can be transported with the aid of motor proteins. (fsu.edu)

Because this picture shows an artist's visualization of a kinesin protein in a white blood cell and not a myosin protein in a neuron, and it is not an actual video but a representation, we rate the claim that this picture is a visual representation of "happiness" as false. (snopes.com)
Molecular motor plays an important role in material transporting and energy converting in cell. (youdao.com)
Reporting online in Cell Systems on April 17, systems biologist Mohammed AlQuraishi details a new approach for computationally determining protein structure-achieving accuracy comparable to current state-of-the-art methods but at speeds upward of a million times faster. (harvard.edu)
This protein drives a number of critical cell processes including muscle contraction, cell division and the movement of materials within cells. (stanford.edu)
In a healthy cell, the production and degradation of protein are integrated with processes that ensure the proper folding of these proteins and the prevention of unfolded proteins aggregating. (edu.au)
We think, by binding to amyloid fibrils, these molecular chaperones protect the cell from their toxic effects. (edu.au)
We have developed a theoretical model that correlates the switching probability of an individual motor protein with the cell-wide redistribution of pigment organelles", says Frey. (lmu.de)
Topics span scales from the workings of proteins, such as a molecular motor, via cell function, looking at nerves, to full organism morphogenesis. (tum.de)
This family of proteins are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. (abnova.com)
Noirclerc-Savoye M, Lantez V, Signor L, Philippe J, Vernet T and Zapun A Reconstitution of membrane protein complexes involved in pneumococcal septal cell wall assembly. (ibs.fr)
Researchers develop a protein called NAP which protects and restores nerve cell communication in some neurodegenerative diseases. (neurosciencenews.com)
It has been shown that the circadian rhythmic potassium flux from/into motor cells triggers cell shrinking/swelling to cause nyctinastic leaf-folding/opening movement in S. saman . (nature.com)
Furthermore, we show that SPORK2 is indispensable for the JAG-triggered shrinkage of the motor cell. (nature.com)
Gene ontology (GO) enrichment analysis showed thatdifferentially expressed genes were most enriched in immune system process, regulation of immune systemprocess, defense response, plasma membrane part, extracellular region part, cell surface, protein binding,receptor binding, glycosaminoglycan binding. (who.int)
Stem cell Therapy For ALS opens wholly new probabilities in the disorder treatment, resulting in the compelling progress of patient's motor action with emotional and mental status. (medacess.com)
Most bacteria are, however, surrounded by a rigid cell wall made out of peptidoglycan , a polymer composed of linked carbohydrates and small proteins. (khanacademy.org)
For instance, although archaea also have a cell wall, it's not made out of peptidoglycan-although it does contain carbohydrates and proteins. (khanacademy.org)
Stem cell-derived cranial and spinal motor neurons reveal proteostatic differences between ALS resistant and sensitive motor neurons. (nyu.edu)
1 Nevertheless, strategies that target protein misfolding frequently reduce aggregate formation and cell death in parallel. (bmj.com)
11, 14 Rouleau and colleagues found that oligomerisation of PABP2 is mediated by two potential oligomerisation domains (ODs)-deletions in either of these domains inactivated oligomerisation of mutant PABP2 and also reduced the cell death caused by this protein. (bmj.com)

But since we describe a molecular pathway by which gene shutdown occurs during stress, these findings may pave the way for new approaches of therapeutic intervention in neurodegenerative diseases in the future," says Ritwick Sawarkar. (mpg.de)
The protein encoded by this gene is a member of kinesin-like protein family. (abnova.com)
The HSPB1 gene provides instructions for making a protein called heat shock protein beta-1 (also called heat shock protein 27). (medlineplus.gov)
Researchers have identified at least 14 HSPB1 gene mutations that cause a condition called distal hereditary motor neuropathy, type II, which is characterized by progressive weakness, primarily in the feet and legs. (medlineplus.gov)
HSPB1 gene mutations that cause distal hereditary motor neuropathy, type II change single protein building blocks (amino acids) in heat shock protein beta-1. (medlineplus.gov)
Elivaldogene autotemcel is a one-time gene therapy designed to add functional copies of the ABCD1 gene into a patient's own hematopoietic stem cells, resulting in the production of the adrenoleukodystrophy protein (ALDP). (medscape.com)
Based on phenotypic characterization, expression analysis and ChIP-seq of Hox genes during in vitro MN differentiation, we plan to identify the enhancer structure at Hox binding sites and to establish the minimal set of cofactors and molecular logic required for Hox gene activity in MNs. (nyu.edu)

Human molecular genetics 2009 Feb 18 (3): 472-81. (cdc.gov)

Amyloid fibrils are misfolded aggregates of proteins that are responsible of major diseases including diabetes, Alzheimer and Parkinson. (cea.fr)
Studies suggest that the altered protein may be more likely to form clusters (aggregates) and block the transport of substances that are essential for the proper function of nerve axons, leading to the signs and symptoms of distal hereditary motor neuropathy, type II. (medlineplus.gov)
Over time, protein aggregates (shown in green) accumulate in the axons of MOCA-deficient mice. (salk.edu)
The animal model used in the study also will allow scientists to better understand the processes behind the formation of the protein aggregates that are common to most neurodegenerative diseases. (salk.edu)
Protein aggregates are common features of most age-related neurological diseases," says Chen, the first author of the study. (salk.edu)
Motor problems such as ataxia may be the most obvious manifestation because the aggregates appear in the long axons of the spinal cord. (salk.edu)

A protein complex, namely NELF, is responsible for stopping transcription at a vast number of genes by physically binding to them," says Fernando Aprile-Garcia, the first author of the publication. (mpg.de)

During in vivo and in vitro differentiation, members of the Hox family of transcription factors impose subtype identity and control motor neuron (MN) connectivity. (nyu.edu)

Satellites are an array of membraneless structures that localize and move around centrosomes and cilia in a microtubule and molecular motor-dependent manner. (molbiolcell.org)
Proteins function by folding into myriad, precise 3D structures. (harvard.edu)
While highly successful, processes that use physical tools to identify protein structures are expensive and time consuming, even with modern techniques such as cryo-electron microscopy. (harvard.edu)
As such, the vast majority of protein structures-and the effects of disease-causing mutations on these structures-are still largely unknown. (harvard.edu)
3D printed protein-based robotic structures actuated by molecular motor assemblies. (mpg.de)
For instance, flagella are whip-like structures that act as rotary motors to help bacteria move. (khanacademy.org)

Overall, this analysis indicates that dMiro's N-terminal GTPase domain is critically required for viability, mitochondrial size, and the distribution of mitochondria out of the neuronal soma regardless of the employed motor, likely by promoting the transition from a stationary to a motile state. (sdbonline.org)

Variations in the arrangement of myosin proteins in the sarcomere or in the myosin protein sequence can lead to changes in myosin activity, thus affecting interfilament sliding velocity and muscle performance. (biologists.com)

Molecular motors are protein machines in cells that move along cytoskeletal filaments (filaments that act like the cell's skeleton, giving it support and shape) using chemical energy from the hydrolysis of adenosine triphosphate (ATP). (europa.eu)
Composed of two heavy chains and four light chains, muscle myosin-II is a hexameric protein that composes the thick filaments in muscle sarcomeres. (biologists.com)

This course will explore the molecular bases for physiological and biochemical diversity among members of the two major domains, Bacteria and Archaea. (berkeley.edu)

However, the molecular mechanism linking JAG and SPORK2 remains elusive. (nature.com)

By identifying innovative approaches to activate molecular chaperones, the group aims to develop new drugs to treat, and ultimately prevent, neurodegenerative diseases such as MND. (edu.au)
The deposition of misfolded proteins is a defining feature of many age-dependent human diseases, including the increasingly prevalent neurodegenerative diseases. (cam.ac.uk)
Therefore, improving the cells' ability to deal with misfolded proteins could be useful to reduce and prevent neurodegenerative diseases. (cam.ac.uk)
This demonstrates that selective inhibition of PPP1R15A can safely prevent two neurodegenerative diseases caused by the misfolding of proteins in mice. (cam.ac.uk)
Parkinson's disease (PD) is a devastating neurodegenerative disorder characterized by progressive motor debilitation, which affects several million people worldwide. (springer.com)

The small heat shock protein Hsp27 (HSPB1) bound to the surface of an a-synuclein amyloid fibril. (edu.au)
The effects of insulin and insulin-like growth factor I on amyloid precursor protein phosphorylation in in vitro and in vivo models of Alzheimer's disease. (shefayekhatam.ir)
MOCA is only found in neurons and regulates the expression of the beta amyloid protein responsible for the Alzheimer's plaques that are the hallmark of the disease. (salk.edu)

Misregulation of this balance can lead to diseases such as Parkinson's Disease, Motor Neuron Disease and Alzheimer's. (edu.au)
In the United States, Muscular Dystrophy Association/ALS centers and ALS Association certified centers have been established at several major medical centers, and in the United Kingdom, the Motor Neurone Disease Association has a network of 18 accredited Motor Neuron Disease Care and Research Centres. (medscape.com)
Genotype-phenotype characterisation of long survivors with motor neuron disease in Scotland. (cdc.gov)
Role of MAPT in Pure Motor Neuron Disease: Report of a Recurrent Mutation in Italian Patients. (cdc.gov)
Genetic epidemiology of motor neuron disease-associated variants in the Scottish population. (cdc.gov)

Other types of stochastic processes control the functioning of molecular motors and the folding of proteins. (cea.fr)

Heat shock protein beta-1 is found in cells throughout the body and is particularly abundant in nerve and muscle cells. (medlineplus.gov)
In nerve cells, this protein helps to organize a network of molecular threads called neurofilaments that maintain the diameter of specialized extensions called axons. (medlineplus.gov)

E7 from human papil omavirus type 16 cooperate to cancer: the European prospective investigation into doi:10.1093/carcin/bgp321 PMID:20047954 target the PDZ protein Na/H exchange regulatory cancer and nutrition study. (who.int)

This is because these are the body's front-line defenders against protein aggregation. (edu.au)
Currently, we are developing a powerful high-throughput microscopy method to screen novel and clinically-approved compounds for their protective properties against MND-related protein aggregation in cultured cells. (edu.au)

In recent years, computational methods have made significant strides in predicting how proteins fold based on knowledge of their amino acid sequence. (harvard.edu)
Now, a Harvard Medical School scientist has used a form of artificial intelligence known as deep learning to predict the 3D structure of a protein based on its amino acid sequence. (harvard.edu)

Molecular distributions, reaction kinetics, enzyme kinetics. (berkeley.edu)

Microtubules are biopolymers that are composed of subunits made from an abundant globular cytoplasmic protein known as tubulin , as illustrated in Figure 1. (fsu.edu)

In performing molecular procedures in the laboratory, it is essential that you keep contamination down to a minimum. (cdc.gov)

for example, many protein-based molecular motors harness the chemical free energy released by the hydrolysis of ATP in order to perform mechanical work. (youdao.com)
Considers how assemblies of macromolecules (molecular motors) convert chemical energy into mechanical work on the nanometer-to-Angstrom scale. (ucsc.edu)

The systems underlying neurodegeneration in ALS are multi-fractional and control through inter-related molecular and genetic lays. (medacess.com)
We use molecular genetic techniques to study the function of neural circuits in Drosophila. (janelia.org)
Studying the interface between sensory and motor systems by combining electrophysiology, behavioral experiments and genetic tools. (janelia.org)
Genetic and transgenic studies are consistent with a model where expanded polyglutamines cause disease by conferring a novel toxic function on the disease proteins. (bmj.com)

Molecular medicine approaches that provide thousands to millions of measurements per sample have revolutionised research on human diseases, development of new medicines, and patient care. (wurmlab.com)

By adding or removing globular tubulin proteins, the length of polymeric microtubules can be increased or decreased. (fsu.edu)

After the Freiburg scientists had, so to speak, set fire in the cells, they were able to reveal step by step the molecular pathway that mediates SITA. (mpg.de)

We tethered a 3.4 kDa polyethylene glycol chain at a defined site within the lumen of the transmembrane protein pore formed by staphylococcal α-hemolysin. (nature.com)
These transmembrane motors represent one of the more accessible possibilities for a useful application of molecular machines. (foresight.org)

In their newest study, team at the Max Planck Institute of Immunobiology and Epigenetics exposed human cells to an acute temperature increase and analyzed the samples by a combination of molecular and biochemical tools. (mpg.de)

A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components. (nih.gov)

Also for students from other BSc programmes who are interested in Bionantechnology, like BSc chemistry/chemical technology (other universities), BSc Molecular life sciences (RU) BSc Molecular Science and Technology (Delft/Leiden). (wur.nl)

abstract = "Pendrin and prestin both belong to a distinct anion transporter family called solute carrier protein 26A, or SLC26A. (elsevier.com)

Molecular Horizons is closely affiliated with The Proteostasis & Disease Research Centre (PDRC) which aims to actively promote collaborative projects and provide a supportive environment to cultivate Australian proteostasis research. (edu.au)
We have also developed new fluorescence-based technology platforms, including a high-throughput flow cytometry system currently being applied in a search for novel drugs to treat motor neurone disease. (edu.au)
This protein is a member of the heat shock protein family, which helps protect cells under adverse conditions such as infection, inflammation, exposure to toxins, elevated temperature, injury, and disease. (medlineplus.gov)
Kampinga HH, Garrido C. HSPBs: small proteins with big implications in human disease. (medlineplus.gov)
It is a chronic and progressive disease characterized predominantly by resting tremors, bradykinesia, muscular rigidity and postural instability, along with several non-motor symptoms [ 1 ]. (springer.com)
Thus, disease is associated with expansions of 12 or more uninterrupted alanines in this nuclear protein. (bmj.com)

How do coiled-coil proteins support intra-Golgi transport? (evanewyork.net)
I will briefly introduce coiled coils and coiled-coil design, and then describe the concept of the Bar motor, a two-footed molecular motor. (sfu.ca)
Our current experimental realisation of the Bar motor combines designed coiled-coil peptides with azobenzene, a compound with UV light-induced conformational switching properties. (sfu.ca)

Pendrin (SLC26A4) is a chloride-iodide transporter that is found at the luminal membrane of follicular cells in the thyroid gland as well as in the endolymphatic duct and sac of the inner ear, whereas prestin (SLC26A5) is expressed in the plasma membrane of cochlear outer hair cells and functions as a unique voltage-dependent motor.Werecently identified a motif that is critical for the motor function of prestin. (elsevier.com)
Of late, my group has been involved in developing novel techniques to study heat-shock chaperone function in cells and a flow cytometry-based method to count and physically isolate protein inclusions from cells. (edu.au)
As response to a heat-shock, for instance, cells start the production of new proteins to help damaged proteins. (mpg.de)
Our data suggest that the signal that the cells need to sense the stress is the increase of the ubiquitin mark in proteins being produced during the stress," explains Aprile-Garcia. (mpg.de)
Extracellular protein: enters cells through endocytosis or pinocytosis and degrades in lysosomes. (evanewyork.net)
Although it is thought to play a role in muscle contraction, the specific function of heat shock protein beta-1 in muscle cells is unclear. (medlineplus.gov)
Here, we report that JAG induces leaf-folding through accumulation of reactive oxygen species in the extensor motor cells of S. saman , and this occurs independently of plant hormone signaling. (nature.com)
Unequal volume changes in the motor cells in the adaxial/abaxial side of the pulvinus cause the leaf movement. (nature.com)

One of the interests of our group in Durham is to design peptide systems which could be combined with other molecular components to produce peptide/protein-based synthetic motors. (sfu.ca)
Peter Freddolino: "Re: protein peptide alignment. (uiuc.edu)

Evaluating the spatial and temporal protein production in neural tissue engineering constructs in vitro<... (asu.pure.elsevier.com)

Embryonic development in a Petri dish | Max-Planck-Gesellschaft (mpg.de)

Social Networking at the Cellular Gateway | Max-Planck-Gesellschaft (mpg.de)

How the coronavirus multiplies its genetic material | Max-Planck-Gesellschaft (mpg.de)

Control of microtubule trajectory within an electric field by altering surface charge density | Scientific Reports (nature.com)

Protein aggregation related diseases - University of Wollongong - UOW (uow.edu.au)

Transcriptome Analysis Reveals Distinct Gene Expression Profiles in Eosinophilic and Noneosinophilic Chronic Rhinosinusitis... (nature.com)

Cyanobacteria use micro-optics to sense light direction | eLife (elifesciences.org)

A Hox Regulatory Network Establishes Motor Neuron Pool Identity and Target-Muscle Connectivity: Cell (cell.com)

Molecular basis for RNA polymerase-dependent transcription complex recycling by the helicase-like motor protein HelD (scholars.uow.edu.au)

Activation of cytoplasmic dynein motility by dynactin-cargo adapter complexes - NASA/ADS (ui.adsabs.harvard.edu)

Clinical Guidelines for Diagnosis and Treatment of Botulism, 2021 | MMWR (cdc.gov)

HSPB1 gene: MedlinePlus Genetics (medlineplus.gov)

Combination molecular therapies for type 1 spinal muscular atrophy | Lurie Children's (luriechildrens.org)

Publications of Friedrich Kragler | Max Planck Institute of Molecular Plant Physiology (mpimp-golm.mpg.de)

Spinal muscular atrophy: untangling the knot? | Journal of Medical Genetics (jmg.bmj.com)

Understanding RNA dysfunction using novel RNA-seq technologies | MND Association (mndassociation.org)

The flavonoid kaempferol protects the fruit fly Drosophila melanogaster against the motor impairment produced by exposure to... (journals.biologists.com)

Sleep Medicine Research Program | Icahn School of Medicine (icahn.mssm.edu)

Ching Chieh Chou's Profile | Stanford Profiles (profiles.stanford.edu)

Anatomy5

Chemicals and Drugs14

Analytical, Diagnostic and Therapeutic Techniques and Equipment3

Psychiatry and Psychology1

Phenomena and Processes6

A processive single-headed motor: kinesin superfamily protein KIF1A. (1/1515)

Microtubule-dependent plus- and minus end-directed motilities are competing processes for nuclear targeting of adenovirus. (2/1515)

The polar flagellar motor of Vibrio cholerae is driven by an Na+ motive force. (3/1515)

p53 and p16INK4A mutations during the progression of glomus tumor. (4/1515)

The meningococcal PilT protein is required for induction of intimate attachment to epithelial cells following pilus-mediated adhesion. (5/1515)

Differences in the ionic interaction of actin with the motor domains of nonmuscle and muscle myosin II. (6/1515)

GMAP-210, A cis-Golgi network-associated protein, is a minus end microtubule-binding protein. (7/1515)

The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex. (8/1515)

Molecular Motor Proteins

Kinesin

Myosin Type V

Dyneins

Microtubules

Motor Neurons

Myosins

Evoked Potentials, Motor

Motor Cortex

Optical Tweezers

Myosin Type I

Microtubule-Associated Proteins

Myosin Heavy Chains

Movement

Cytoplasmic Dyneins

Motor Activity

Hair Cells, Auditory, Outer

Adenosine Triphosphate

Motion

Actins

Microtubule Proteins

Myosin Type II

Models, Biological

Axonal Transport

Spindle Apparatus

Protein Transport

Adenosine Triphosphatases

Models, Molecular

A processive single-headed motor: kinesin superfamily protein KIF1A. (1/1515)

Microtubule-dependent plus- and minus end-directed motilities are competing processes for nuclear targeting of adenovirus. (2/1515)

The polar flagellar motor of Vibrio cholerae is driven by an Na+ motive force. (3/1515)

p53 and p16INK4A mutations during the progression of glomus tumor. (4/1515)

The meningococcal PilT protein is required for induction of intimate attachment to epithelial cells following pilus-mediated adhesion. (5/1515)

Differences in the ionic interaction of actin with the motor domains of nonmuscle and muscle myosin II. (6/1515)

GMAP-210, A cis-Golgi network-associated protein, is a minus end microtubule-binding protein. (7/1515)

The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex. (8/1515)

Solution 1 (SFOC on the joints) HALLOW SHAFT MOTOR J1 J2J3 ELBOW HAND ETH IN ETH OUT PS DC MOTORS CAN SKIN2 CAN FTSENSOR ETH IN...

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A chemically powered unidirectional rotary molecular motor based on a palladium redox cycle<...

Motor Proteins as Novel Drug Targets of Disease-modifying Treatments for Parkinson s Disease | Parkinsons Disease

Chemical fuel keeps molecular motor moving - Foresight Institute

Patent US20090131830 - Method and Apparatus for Penetrating tissue - Google Patents

Tug-of-War in Motor Protein Ensembles Revealed with a Programmable DNA Origami Scaffold | Science

Endow, Sharyn Anne | University Program in Genetics & Genomics

February | 2016 | The Hirst Lab

The reciprocal coordination and mechanics of molecular motors in living cells | PNAS

Plus it

Exact dynamic properties of molecular motors. - Surrey Research Insight Open Access

Calendar of Events | News & Events | Amherst College

Courses

Tyska Lab - Labnodes - The Vanderbilt Research Network

Matthew Tyska - Resource Collections - Labnodes - The Vanderbilt Research Network

Difference between revisions of De la Cruz:Research - OpenWetWare

Molecular Motors FAQs | Center for Nanoscale Science

Peering under the hood into the workings of molecular motors | EurekAlert! Science News

Molecular Motor Crossing The Frontier Of Classical To Quantum Tunneling Motion - DPL

DNA origami to scale-up molecular motors | EurekAlert! Science News

RNA polymerases as molecular motors (Book, 2009) [WorldCat.org]

Difference between revisions of De la Cruz:Research - OpenWetWare

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Taylor Motors - Redding, CA 96002 - (530)276-8948 | ShowMeLocal.com

Researchers identify molecular motor that transforms chromosomes

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Chevrolet Camaro Questions - I am looking for a taligate acutuator. - CarGurus

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Kinesin motor protein - Stock Image F009/6428 - Science Photo Library

Axonopathy and Transport Deficits Early in the Pathogenesis of Alzheimers Disease | Science