Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.Fermentation: Anaerobic degradation of GLUCOSE or other organic nutrients to gain energy in the form of ATP. End products vary depending on organisms, substrates, and enzymatic pathways. Common fermentation products include ETHANOL and LACTIC ACID.Streptomyces: A genus of bacteria that form a nonfragmented aerial mycelium. Many species have been identified with some being pathogenic. This genus is responsible for producing a majority of the ANTI-BACTERIAL AGENTS of practical value.Chemistry: A basic science concerned with the composition, structure, and properties of matter; and the reactions that occur between substances and the associated energy exchange.Chemical Phenomena: The composition, conformation, and properties of atoms and molecules, and their reaction and interaction processes.Physicochemical Phenomena: The physical phenomena describing the structure and properties of atoms and molecules, and their reaction and interaction processes.Chemistry, Physical: The study of CHEMICAL PHENOMENA and processes in terms of the underlying PHYSICAL PHENOMENA and processes.Streptomycetaceae: A family of soil bacteria. It also includes some parasitic forms.Infant Formula: Liquid formulations for the nutrition of infants that can substitute for BREAST MILK.Spectrophotometry, Infrared: Spectrophotometry in the infrared region, usually for the purpose of chemical analysis through measurement of absorption spectra associated with rotational and vibrational energy levels of molecules. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Magnetic Resonance Spectroscopy: Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).Anti-Bacterial Agents: Substances that reduce the growth or reproduction of BACTERIA.Mass Spectrometry: An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.Antibiotics, Antineoplastic: Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms.Mitosporic Fungi: A large and heterogenous group of fungi whose common characteristic is the absence of a sexual state. Many of the pathogenic fungi in humans belong to this group.Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Fungi: A kingdom of eukaryotic, heterotrophic organisms that live parasitically as saprobes, including MUSHROOMS; YEASTS; smuts, molds, etc. They reproduce either sexually or asexually, and have life cycles that range from simple to complex. Filamentous fungi, commonly known as molds, refer to those that grow as multicellular colonies.Gram-Positive Bacteria: Bacteria which retain the crystal violet stain when treated by Gram's method.Spectrometry, Mass, Fast Atom Bombardment: A mass spectrometric technique that is used for the analysis of a wide range of biomolecules, such as glycoalkaloids, glycoproteins, polysaccharides, and peptides. Positive and negative fast atom bombardment spectra are recorded on a mass spectrometer fitted with an atom gun with xenon as the customary beam. The mass spectra obtained contain molecular weight recognition as well as sequence information.Leukemia P388: An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.Lethal Dose 50: The dose amount of poisonous or toxic substance or dose of ionizing radiation required to kill 50% of the tested population.Spectrophotometry, Ultraviolet: Determination of the spectra of ultraviolet absorption by specific molecules in gases or liquids, for example Cl2, SO2, NO2, CS2, ozone, mercury vapor, and various unsaturated compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Bacteria: One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.Actinomycetales: An order of gram-positive, primarily aerobic BACTERIA that tend to form branching filaments.Chromatography, High Pressure Liquid: Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.Infant Food: Food processed and manufactured for the nutritional health of children in their first year of life.Antifungal Agents: Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.Chromatography, Thin Layer: Chromatography on thin layers of adsorbents rather than in columns. The adsorbent can be alumina, silica gel, silicates, charcoals, or cellulose. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Microbial Sensitivity Tests: Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).Purinergic P2 Receptor Antagonists: Compounds that bind to and block the stimulation of PURINERGIC P2 RECEPTORS.Receptors, Purinergic P2: A class of cell surface receptors for PURINES that prefer ATP or ADP over ADENOSINE. P2 purinergic receptors are widespread in the periphery and in the central and peripheral nervous system.Infant Nutritional Physiological Phenomena: Nutritional physiology of children from birth to 2 years of age.Pyridoxal Phosphate: This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE).Milk, HumanUridine Triphosphate: Uridine 5'-(tetrahydrogen triphosphate). A uracil nucleotide containing three phosphate groups esterified to the sugar moiety.Adenosine Triphosphate: An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.Receptors, Purinergic: Cell surface proteins that bind PURINES with high affinity and trigger intracellular changes which influence the behavior of cells. The best characterized classes of purinergic receptors in mammals are the P1 receptors, which prefer ADENOSINE, and the P2 receptors, which prefer ATP or ADP.Purinergic Antagonists: Drugs that bind to and block the activation of PURINERGIC RECEPTORS.Purinergic P2 Receptor Agonists: Compounds that bind to and stimulate PURINERGIC P2 RECEPTORS.Bottle Feeding: Use of nursing bottles for feeding. Applies to humans and animals.Receptors, Purinergic P2X: A subclass of purinergic P2 receptors that signal by means of a ligand-gated ion channel. They are comprised of three P2X subunits which can be identical (homotrimeric form) or dissimilar (heterotrimeric form).Protein HydrolysatesPurinergic P2X Receptor Antagonists: Compounds that bind to and block the stimulation of PURINERGIC P2X RECEPTORS. Included under this heading are antagonists for specific P2X receptor subtypes.Breast Feeding: The nursing of an infant at the breast.Milk: The white liquid secreted by the mammary glands. It contains proteins, sugar, lipids, vitamins, and minerals.Drugs, Chinese Herbal: Chinese herbal or plant extracts which are used as drugs to treat diseases or promote general well-being. The concept does not include synthesized compounds manufactured in China.Soy Milk: A beverage prepared from SOYBEANS.Milk Hypersensitivity: Allergic reaction to milk (usually cow's milk) or milk products. MILK HYPERSENSITIVITY should be differentiated from LACTOSE INTOLERANCE, an intolerance to milk as a result of congenital deficiency of lactase.Infant, Newborn: An infant during the first month after birth.Enteral Nutrition: Nutritional support given via the alimentary canal or any route connected to the gastrointestinal system (i.e., the enteral route). This includes oral feeding, sip feeding, and tube feeding using nasogastric, gastrostomy, and jejunostomy tubes.Biological Science Disciplines: All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.Salts: Substances produced from the reaction between acids and bases; compounds consisting of a metal (positive) and nonmetal (negative) radical. (Grant & Hackh's Chemical Dictionary, 5th ed)Sodium: A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.Death Certificates: Official records of individual deaths including the cause of death certified by a physician, and any other required identifying information.Sodium Chloride: A ubiquitous sodium salt that is commonly used to season food.Birth Certificates: Official certifications by a physician recording the individual's birth date, place of birth, parentage and other required identifying data which are filed with the local registrar of vital statistics.
... is not extensively metabolized and about 80% is eliminated via the kidneys. The molecular formula of suramin is ... The formula of suramin was kept secret by Bayer for commercial reasons, however, it was elucidated and published in 1924 by ... Suramin was studied as a possible treatment for prostate cancer in a clinical trial. Suramin has been studied in a mouse model ... Suramin can also cause loss of appetite and irritability. Suramin causes non-harmful changes in urine during use, specifically ...
The Journal of Steroid Biochemistry and Molecular Biology. 78 (3): 231-9. doi:10.1016/S0960-0760(01)00098-X. PMID 11595503.. ... Chemical formula. C15H10O4 Molar mass 7002254241000000000♠254.241 g·mol−1 ...
"Molecular Genetics and Genomics. 267 (5): 636-646. doi:10.1007/s00438-002-0697-y. ISSN 1617-4615.. ... Formula. C23H34O5. Molar mass. 390.52 g·mol−1. ... "Crystal and molecular structure of compactin, a new antifungal ... "Molecular cloning and characterization of an ML-236B (compactin) biosynthetic gene cluster in Penicillium citrinum" ...
"Journal of Molecular Biology. 354 (4): 789-800. doi:10.1016/j.jmb.2005.09.095. PMC 1403828. PMID 16277992.. ... Formula. C36H47N5O4. Molar mass. 613.803 g·mol−1. ... Suramin. *Tacrolimus. *Tenylidone. *Terconazole. *Testosterone ...
"A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene ... Formula. C7H8N4O2. Molar mass. 180.164 g/mol g·mol−1. ... Suramin. *TC-P 262. *Tetramethylpyrazine (ligustrazine) ( ...
Molecular Pharmacology. 74 (4): 980-9. doi:10.1124/mol.108.048207. PMID 18621927.. ... Chemical formula. C7H8N4O2 Molar mass 180.167 g·mol−1 ... Suramin. *TC-P 262. *Tetramethylpyrazine (ligustrazine) ( ...
... the molecular weight) and on the amount of dye bound to the protein. ... Chemical formula. C45H44N3NaO7S2 (Sodium salt) ... Suramin. *TC-P 262. *Tetramethylpyrazine (ligustrazine) ( ...
... "molecular unit of currency", ATP is continually being reformed from lower-energy species ADP and AMP. The biosynthesis of ATP ... Chemical formula. C10H15N5O10P2. ... Suramin. *TC-P 262. *Tetramethylpyrazine (ligustrazine) ( ...
"Molecular Pharmacology. 40 (3): 333-6. PMID 1654510.. *^ Irwin RP, Maragakis NJ, Rogawski MA, Purdy RH, Farb DH, Paul SM (July ... Chemical formula. C21H32O2 Molar mass 316.485 g/mol ... Suramin. *Tacrolimus. *Tenylidone. *Terconazole. *Testosterone ...
The Journal of Steroid Biochemistry and Molecular Biology. 46 (5): 597-603. doi:10.1016/0960-0760(93)90187-2. ISSN 0960-0760.. ... Formula. C19H30O2. Molar mass. 290.44 g/mol. ... Suramin. *Tacrolimus. *Tenylidone. *Terconazole. *Testosterone ...
Daly JW (August 2007). "Caffeine analogs: biomedical impact". Cellular and Molecular Life Sciences : CMLS. 64 (16): 2153-69. ... Chemical formula. C5H4N4O2 Molar mass 152.11 g/mol ... Suramin. *TC-P 262. *Tetramethylpyrazine (ligustrazine) ( ...
"Molecular Psychiatry. 15 (3): 237-49. doi:10.1038/mp.2009.80. PMC 2902200. PMID 19704408.. ... Formula. C21H25ClN2O4S. Molar mass. 436.953 g/mol. ... McEwen, BS; Chattarji, S (December 2004). "Molecular mechanisms ... Molecular Psychiatry. 10 (6): 525-37. doi:10.1038/sj.mp.4001648. PMID 15753957.. ...
"Medicinal chemistry and molecular pharmacology of GABA(C) receptors" (PDF). Curr Top Med Chem. 2 (8): 903-13. doi:10.2174/ ... Chemical formula. C21H32O2. Molar mass. 316.48 g/mol. ... Suramin. *Tacrolimus. *Tenylidone. *Terconazole. *Testosterone ...
The formula of suramin was kept secret by Bayer for commercial reasons, but it was elucidated and published in 1924 by Ernest ... Methods in Molecular Biology™. 460. pp. 221-238. doi:10.1007/978-1-60327-048-9_11. ISBN 978-1-58829-638-2. . PMID 18449490.. ... In 1916 Bayer scientists discovered suramin, an anti-parasite drug that is still sold by Bayer under the brand name Germanin. ...
Suramin is not extensively metabolized and about 80% is eliminated via the kidneys. The molecular formula of suramin is ... The formula of suramin was kept secret by Bayer for commercial reasons, however, it was elucidated and published in 1924 by ... Suramin was studied as a possible treatment for prostate cancer in a clinical trial. Suramin has been studied in a mouse model ... Suramin can also cause loss of appetite and irritability. Suramin causes non-harmful changes in urine during use, specifically ...
The molecular formula of suramin is C51H40N6O23S6. It is a symmetric molecule in the center of which lies a urea (NH-CO-NH) ... The formula of suramin was kept secret by Bayer for commercial reasons, however, it was elucidated and published in 1924 by ... It is common for patients to get a tingling or crawling sensation of the skin with suramin. Suramin will cause clouding of the ... Suramin is also used in research as a broad-spectrum antagonist of P2 receptors[11][12] and agonist of Ryanodine receptors.[13] ...
Min Assay Active Pharmaceutical Ingredient Suramin Sodium API Powder CAS 129-46-4 from China manufacturer. ... Molecular Formula. C51H34N6O23S6•6Na. Molecular Weight. 1429.17 g·mol−1. Chemical Names. Suramin hexasodium salt; Suramin ... Suramin Hexasodium Salt; Suramin Hexasodium; Suramin Sodium Salt. Formula:. C51H34N6O23S6•6Na. Formula Weight:. 1429.17 G·mol−1 ... Suramin Sodium is actually a sodium salt type of suramin, a polysulphonated naphthylurea with prospective antineoplastic ...
Suramin has online i directions that limit its moet in the tablets breast of ordering fractional less bad and subsequent ... Molecular product reveals redkinmy variables of encouraging balanced antibiotics.. Doxycycline binds less partially to crush ... We did again recognize that doxycycline loss formula.. Unitwithin three voice inhaler alkaline doxycycline brand keep all ...
Molecular Formula. C₇H₆N₄. Molecular Weight. 146.15. Purity. ≥98%. Solubility. >50 mg/ml in DMSO. ... Molecular Biology Tools NEW!. Product Catalog. Protease & Phosphatase Inhibitor Cocktails. Protein Extraction. Stem Cell ...
... and having a molecular weight of at most 1,000,000 (n≦1544). ... of a polysaccharide having repeating units of the formula: ## ... n in the formula (1) being at most 1544), preferably at most 5×105 (n in the formula (1) being at most 772). If the molecular ... However, substances such as azidothymidine (AZT), dideoxycytidine, dideoxyadenosine, suramin, ribavirin, HPA-23 and interferon ... TABLE 7______________________________________Acute toxicity test of schizophyllan sulfates Molecular weight Molecular weight of ...
View our Suramin sodium salt specific physical and chemical properties, and analytical data. ... COA of Suramin sodium salt contains the actual results obtained from testing performed as part of quality control. ... Formula:. C51H34N6Na6O23S6. ... Molecular Weight:. 1429.17. Solubility:. 100 mg/mL in water. ... Suramin sodium salt is a polysulfonated naphthylurea that inhibits the binding of calmodulin to recognition sites on the ...
The polyorthoester described by formula (V) can have molecular weight within a range of between about 20,000 and about 200,000 ... suramin, serotonin blockers, steroids, thioprotease inhibitors, triazolopyrimidine (a PDGF antagonist), and nitric oxide. An ... If both R and R1 in formula (I) are methyl groups, formula (I) describes the molecule of DETOSU. For DPTOSH, both R and R1 in ... The molecular weight of the PEG units can be about 300 Daltons. The overall weight-averaged molecular weight (Mw) of POLYACTIVE ...
0092] In formulae 4 X may be SO3Na or H. [0093] Examples of glycan mimetics include low-molecular weight anionic glycan mimetic ... suramin and suramin analogues. [0088] The sulfated polysaccharide is selected from the group comprising heparin, λ-carrageenan ... 0090] In formulae 1 and 3 X may be SO3Na or H. [0091] An Example of a phosphosulfomannan heparan sulfate mimetic is formulae 4 ... Low Molecular Weight Heparin Derivatives: [0204] Low molecular weight heparin (sodium salt) from porcine intestinal mucosa, ...
View detailed Topo II Inhibitor specifications, including Topo II Inhibitor CAS number, molecular weight, molecular formula and ... Suramin sodium A G protein uncoupler and inhibitor of PDGF, EGF, TGFb, SIRT1 and SIRT5 129-46-4. sc-200833 sc-200833A sc- ...
... having the formula H-CO-N(CH3)2, tethrahydrofurane (THF) having the formula C4H8O, dimethylsulphoxide (DMSO) having the formula ... SP-A is a glycoprotein with a molecular weight of about 30,000 Daltons. The human SP-A peptide comprises a sequence of 248 ... suramin, serotonin blockers, steroids, thioprotease inhibitors, triazolopyrimidine (a PDGF antagonist), and nitric oxide. An ... PEG has the formula H[O-CH2-CH2-O-CH2-CH2-O]nH. PEG, a biologically compatible product, can be in an oligomeric or polymeric ...
... especially a phosphorodiamidate mustard of the formula -OP(═O)(NHCH2CH2X)2 or -OP(═O)(N(CH2CH2X)2, particularly of the formula ... 3. The method of claim 1 where the another anticancer therapy is selected from one or more of chemotherapy, molecular targeted ... mitotane, octreotide, procarbazine, suramin, thalidomide, lenalidomide, photodynamic compounds such as methoxsalen and sodium ... Glutathione (GSH), in its reduced form, is a tripeptide of the formula: γ-L-Glu-L-Cys-Gly. Reduced glutathione has a central ...
UC San Diego researchers developed a formula to more accurately compare dog age to human age - a tool that could also help them ... By mapping molecular changes in the genome over time, ... By mapping molecular changes in the genome over time, UC San ... Instead, they created a formula that more accurately compares the ages of humans and dogs. The formula is based on the changing ... The formula provides a new "epigenetic clock," a method for determining the age of a cell, tissue or organism based on a ...
Suramin (14 μmol/L) is used as a positive control. C, quantitation of results shown in B. 4HPR concentration was 5 μmol/L. ... at regular intervals by measuring two tumor diameters with calipers and calculating the tumor volumes with the formula length ... may be interacting with an entire network of molecular and cellular targets, rather than at a single molecular locus or in a ... Several known individual molecular targets of CDDO-Me and related triterpenoids that are relevant to all of these findings ...
Formerly, the treatment was with diethyl carbamazine for the microfilaria and suramin for the adult worm. These drugs are now ... Rapid molecular assays for specific detection and quantitation of Loa loa microfilaremia. ... be considered in all patients who come from or have stayed in endemic areas or who present alterations in the leukocyte formula ... These filarial species-specific molecular protocols were evaluated in forty blood samples from African adult immigrants ...
Compounds with a wide range of molecular weight can be encapsulated, for example, between 100 and 500,000 grams or more per ... wherein the block copolymer has a formula comprising three blocks, the middle block having repeating units of the following ... suramin, serotonin blockers, steroids, thioprotease inhibitors, triazolopyrimidine (a PDGF antagonist), and nitric oxide. An ... These include hydrophobic, hydrophilic, and high molecular weight macromolecules such as proteins. The bioactive compound can ...
The diol that can be used to make diol-diamines having formula (III) has the formula HO-(CH2)x-OH, where x is defined above. ... High molecular weight linear polyester-amides. US3773737. 9 Jun 1971. 20 Nov 1973. Sutures Inc. Hydrolyzable polymers of amino ... suramin, serotonin blockers, steroids, thioprotease inhibitors, triazolopyrimidine (a PDGF antagonist), and nitric oxide. An ... The amino acid that can be used to prepare diol-diamines having formula (III) has the formula H2N-CHR-COOH, where R is defined ...
Pretreatment with topoisomerase II catalytic inhibitors, ICRF-193 and suramin, reduced both cleavable complex-mediated DNA ... Chemical Formula: C22H20ClNO4 Exact Mass: Molecular Weight: 397.85 Elemental Analysis: C, 66.42; H, 5.07; Cl, 8.91; N, 3.52; O ... Pretreatment with topoisomerase II catalytic inhibitors, ICRF-193 and suramin, reduced both cleavable complex-mediated DNA ...
Leibniz Institute for Molecular Pharmacology) for help in protein modeling; F. Hinterleitner (Leibniz Institute for Molecular ... Hits with differences in fitting scores according to the formula 2×FS(Shp2)−FS(Shp1)−FS(PTP1B) ,20 were regarded as specific. ... suramin, and NSC-87877 in SI Text, Results). These findings show that PHPS1 is a selective inhibitor of Shp2, because it can ... 2002) Molecular modeling of protein tyrosine phosphatase 1B (PTP 1B) inhibitors. Bioorg Med Chem 10:897-906. ...
Compounds with a wide range of molecular weight can be encapsulated, for example, between 100 and 500,000 grams or more per ... wherein the block copolymer has a formula comprising three blocks, the middle block having repeating units of the following ... suramin, serotonin blockers, steroids, thioprotease inhibitors, triazolopyrimidine (a PDGF antagonist), and nitric oxide. An ... In a further embodiment, the block copolymer has a formula of the following structure: ...
Molecular Formula: C9H11FN2O5. Molecular Weight: 246.19 ... Suramin Sodium. Actinoquinol. Chondrocurine. Phosphorus ...
The diol that can be used to make diol-diamines having formula (III) has the formula HO-(CH2)x-OH, where x is defined above. ... Both monomer 1 and monomer 2 can have stoichiometry as close as to 1:1 as possible in order to reach high molecular weights. ... suramin, serotonin blockers, steroids, thioprotease inhibitors, triazolopyrimidine (a PDGF antagonist), and nitric oxide. An ... The amino acid that can be used to prepare diol-diamines having formula (III) has the formula H2N-CHR-COOH, where R is defined ...
... associate professor in the UC San Diego departments of Pediatrics and Cellular and Molecular Medicine. "This affects science in ... or DOE to determine the optimal cell culture formula to grow and produce hPSCs. ... Department of Cellular and Molecular Medicine and UCSD Stem Cell Program. ...
Antiproliferative and cytotoxic effects of geldanamycin, cytochalasin E, suramin and thiacetazone in human prostate xenograft ... Structural formula of geldanamycin. Molecular studies revealed the binding of GA to members of the heat shock protein 90 (Hsp90 ... Chen C-F, Chen Y, Dai K, Chen P-L, Riley DJ, Lee W-H. A new member of the Hsp90 family of molecular chaperones interacts with ... ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo. EMBO J. 1998;17:4829-4836. [ ...
... a low molecular weight hydrocarbon, a ketone, an ester, a halogenated low molecular weight hydrocarbon or a mixture of any of ... Spacers containing biodegradable methylene diester or diamide groups of formula --(Z).sub.m.Y.X.C(R.sup.1R.sup.2).X.Y.(Z).sub.n ... Suramin EC of tumors K Taxol EC of tumors K thalidomide EC of tumors K Thrombospondin EC of tumors K [0140] Vectors Comprising ... 0075] Appropriate molecular weights for PEG spacers used in accordance with the invention may, for example, be between 120 ...
  • Suramin is a medication used to treat African sleeping sickness and river blindness. (wikipedia.org)
  • In a small, randomized Phase I/II clinical trial (SAT1), researchers at University of California San Diego School of Medicine say a 100-year-old drug called suramin, originally developed to treat African sleeping sickness, was safely administered to children with autism spectrum disorder (ASD), who subsequently displayed measurable, but transient, improvement in core symptoms of autism. (gordonmedical.com)
  • An anti-AIDS virus agent comprising a sulfate of a polysaccharide having repeating units of the formula: ##STR1## and having a molecular weight of at most 1,000,000 (n≦1544). (google.com)
  • View detailed Topo II Inhibitor specifications, including Topo II Inhibitor CAS number, molecular weight, molecular formula and chemical structure, by clicking on the product name. (scbt.com)
  • wherein x is an integer representing a number of ethylene oxide fragments, y is an integer representing a number of propylene oxide fragments, and the integers are selected such that the molecular weight of the polyol ranges from about 950 to about 4000 Daltons. (google.com)
  • 9. The method of claim 1 , wherein the first or second drug, therapeutic agent, medicine, compound or active agent comprises a low molecular weight salt of a size that can penetrate cells of tissue at a diseased site. (google.com)
  • We performed a high-throughput in silico screen for small-molecular-weight compounds that bind the catalytic site of Shp2. (pnas.org)
  • He looked different, dressed in regular street clothes, and ate, and left within ten minutes Amazon's Choice for phentermine 37.5 mg Atrafen Elite - Professional Formula Appetite Suppressant Fat Burner Diet Pill and Thermogenic for Fast Weight Loss. (phentermineadipexbuy.com)
  • Terconazole has a melting point of 126.3 °C (259.34 °F). The molecular weight of terconazole is 532.462 g/mol. (rug.nl)
  • The molecular weight of plerixafor is 502.79 g/mol. (blogspot.com)
  • The mechanism of action for suramin is unclear, however, it is thought that parasites are able to selectively uptake suramin via receptor-mediated endocytosis of drug that is bound to low-density lipoproteins and to a lesser extent, other serum proteins. (wikipedia.org)
  • Once inside parasites, suramin combines with proteins, especially trypanosomal glycolytic enzymes to inhibit energy metabolism. (wikipedia.org)
  • In addition, it is desirable to attempt to relate the antitumor activity of a candidate compound with molecular effects on proteins relevant for the pathogenesis of malignant diseases. (pubmedcentralcanada.ca)
  • The molecular functions of this most important class of fungal effectors and the evolutionary mechanisms that generate this tremendous numbers of apparently unrelated proteins are largely unknown. (prolekare.cz)
  • However, the particularly potent antiangiogenic activity seen in vivo in the present experiments suggest that CDDO-Me, as an angioprevention agent, may be interacting with an entire network of molecular and cellular targets, rather than at a single molecular locus or in a single-cell type. (aacrjournals.org)
  • There are several factors that may affect the growth of stem cells based on batch-to-batch media variation," said Alysson Muotri, PhD, associate professor in the UC San Diego departments of Pediatrics and Cellular and Molecular Medicine. (ucsd.edu)
  • Co-authors include Paulo A. Marinho and Thanathom Chailangkarn, UCSD Department of Pediatrics/Rady Children's Hospital-San Diego, Department of Cellular and Molecular Medicine and UCSD Stem Cell Program. (ucsd.edu)
  • At the molecular level, cellular homeostasis or equilibrium is altered, creating an abnormal cellular response that leads to chronic disease. (gordonmedical.com)
  • Suramin works by inhibiting the signaling function of adenosine triphosphate (ATP), a nucleotide or small molecule produced by cellular mitochondria and released from the cell as a danger signal. (gordonmedical.com)
  • Every experienced dermatologist and pathologist is familiar with these melanoma-like lesions, which are When molecular biological methods are used for melanoma staging, detection of tyrosinase activity in the blood is important, as tyrosinase is a precursor enzyme for melanin formation. (flandershealth.us)
  • Suramin contains six aromatic systems - four benzene rings, sandwiched by a pair of naphthalene moieties - plus four amide functional groups (in addition to the urea) and six sulfonic acid groups. (wikipedia.org)
  • Cisplatin resistance is due to a broad panel of molecular and functional alterations, including the reduced intracellular accumulation through the copper transporter 1 (Ctr1) and the increased efflux through the cell membrane ( 2 ). (aacrjournals.org)
  • Suramin contains eight benzene rings , four of which are fused in pairs ( naphthalene ), four amide groups (in addition to the urea) and six sulfonic acid groups. (wikidoc.org)
  • Extensive and partial protein hydrolysate preterm formulas: the effect on growth rate, protein metabolism indices, and plasma amino acid concentrations. (termsreign.ga)
  • The complexes with the formula La(Gly)3(Phen).3H2O (Gly is Glycine amino acid, Phen is 1,10-phenanthroline) were synthesized and characterized by elemental analysis, FTIR spectrum, Raman spectrum and DTA-TG-FTIR spectrum. (saladgaffe.ml)
  • Writing in the May 4 online issue of the journal Scientific Reports , researchers at University of California, San Diego School of Medicine used a powerful statistical tool called "design of experiments" or DOE to determine the optimal cell culture formula to grow and produce hPSCs. (ucsd.edu)
  • Suramin has been applied clinically to HIV/AIDS patients resulting in a significant number of fatal occurrences and as a result the application of this molecule was abandoned for this condition. (wikipedia.org)
  • For the first time, a molecular chaperone was identified as the target molecule of an anticancer drug. (pubmedcentralcanada.ca)
  • Instead, they created a formula that more accurately compares the ages of humans and dogs. (ucsd.edu)
  • Given the importance of molecular recognition in virus replication, such conformational change might also reduce the effectiveness of neuraminidase (N1) for cleaving the sialic groups necessary for virus replication. (blogspot.in)
  • 3. The method of claim 1 where the another anticancer therapy is selected from one or more of chemotherapy, molecular targeted therapy, biologic therapy, and radiotherapy. (freepatentsonline.com)
  • The formula provides a new "epigenetic clock," a method for determining the age of a cell, tissue or organism based on a readout of its epigenetics - chemical modifications like methylation, which influence which genes are "off" or "on" without altering the inherited genetic sequence itself. (ucsd.edu)
  • Side shavehead or airway licensed to doxycycline fast acting prescribe controlled lungs by the response in which the doctor no meridia needed tablets rosacea for molecular method. (upsoft.pl)
  • Readers are advised to check the most current information provided (i) on procedures featured or (ii) by the manufacturer of each product to be administered, to verify the recommended dose or formula, the method and duration of administration, and contraindications. (b-ok.org)
  • however, the pharmacokinetics of suramin can vary substantially between individual patients. (wikipedia.org)
  • Several known individual molecular targets of CDDO-Me and related triterpenoids that are relevant to all of these findings include nuclear factor-κB signaling, signal transducers and activators of transcription signaling, and transforming growth factor-β signaling, as well as Keap1, the endogenous inhibitor of the transcription factor Nrf2. (aacrjournals.org)
  • The new methylation-based formula, published July 2 in Cell Systems , is the first that is transferrable across species. (ucsd.edu)
  • Considerable effort has now been given to the functionalization of coumarin so that metal-coumarin complexes may be synthesized towards the development of artificial photosynthetic systems, chemical sensors, and molecular level devices [ 29 ]. (ijpsonline.com)
  • Suramin blocks the binding of several development components, like insulin-like improvement element I (IGF-I), epidermal improvement element (EGF), platelet-derived improvement aspect (PDGF), and tumor improvement factor-beta (TGF-beta), to their receptors, thereby inhibiting endothelial cell proliferation and migration. (pharmagrade-steroids.com)
  • Ideker and others have previously published epigenetic clocks for humans, but they are limited in that they may only be accurate for the specific individuals on whom the formulas were developed. (ucsd.edu)
  • Suramin is used for treatment of human sleeping sickness caused by trypanosomes. (wikipedia.org)
  • The formula is based on the changing patterns of methyl groups in dog and human genomes - how many of these chemical tags and where they're located - as they age. (ucsd.edu)