Molecular biology. Medical search

A discipline concerned with studying biological phenomena in terms of the chemical and physical interactions of molecules.

One of the BIOLOGICAL SCIENCE DISCIPLINES concerned with the origin, structure, development, growth, function, genetics, and reproduction of animals, plants, and microorganisms.

Comprehensive, methodical analysis of complex biological systems by monitoring responses to perturbations of biological processes. Large scale, computerized collection and analysis of the data are used to develop and test models of biological systems.

The field of biology which deals with the process of the growth and differentiation of an organism.

A field of biology concerned with the development of techniques for the collection and manipulation of biological data, and the use of such data to make biological discoveries or predictions. This field encompasses all computational methods and theories for solving biological problems including manipulation of models and datasets.

Time period from 1901 through 2000 of the common era.

Time period from 2001 through 2100 of the common era.

A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.

Sequential operating programs and data which instruct the functioning of a digital computer.

A field of biological research combining engineering in the formulation, design, and building (synthesis) of novel biological structures, functions, and systems.

Body of knowledge related to the use of organisms, cells or cell-derived constituents for the purpose of developing products which are technically, scientifically and clinically useful. Alteration of biologic function at the molecular level (i.e., GENETIC ENGINEERING) is a central focus; laboratory methods used include TRANSFECTION and CLONING technologies, sequence and structure analysis algorithms, computer databases, and gene and protein structure function analysis and prediction.

Lists of persons or organizations, systematically arranged, usually in alphabetic or classed order, giving address, affiliations, etc., for individuals, and giving address, officers, functions, and similar data for organizations. (ALA Glossary of Library and Information Science, 1983)

The systematic study of the complete DNA sequences (GENOME) of organisms.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.

A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.

Databases devoted to knowledge about specific genes and gene products.

The branch of science concerned with the means and consequences of transmission and generation of the components of biological inheritance. (Stedman, 26th ed)

Extensive collections, reputedly complete, of facts and data garnered from material of a specialized subject area and made available for analysis and application. The collection can be automated by various contemporary methods for retrieval. The concept should be differentiated from DATABASES, BIBLIOGRAPHIC which is restricted to collections of bibliographic references.

A coordinated effort of researchers to map (CHROMOSOME MAPPING) and sequence (SEQUENCE ANALYSIS, DNA) the human GENOME.

The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.

Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)

The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.

A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.

Organized activities related to the storage, location, search, and retrieval of information.

The study of the composition, chemical structures, and chemical reactions of living things.

Time period from 1801 through 1900 of the common era.

In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.

Disciplines that apply sciences to law. Forensic sciences include a wide range of disciplines, such as FORENSIC TOXICOLOGY; FORENSIC ANTHROPOLOGY; FORENSIC MEDICINE; FORENSIC DENTISTRY; and others.

Chromosomal, biochemical, intracellular, and other methods used in the study of genetics.

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.

The portion of an interactive computer program that issues messages to and receives commands from a user.

New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.

Software designed to store, manipulate, manage, and control data for specific uses.

Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.

The relationships of groups of organisms as reflected by their genetic makeup.

Cellular processes, properties, and characteristics.

A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).

Societies whose membership is limited to scientists.

The process of cumulative change over successive generations through which organisms acquire their distinguishing morphological and physiological characteristics.

Computer-based representation of physical systems and phenomena such as chemical processes.

The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.

The genetic complement of an organism, including all of its GENES, as represented in its DNA, or in some cases, its RNA.

Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.

Specific languages used to prepare computer programs.

The chemical processes, enzymatic activities, and pathways of living things and related temporal, dimensional, qualitative, and quantitative concepts.

Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.

Directed modification of the gene complement of a living organism by such techniques as altering the DNA, substituting genetic material by means of a virus, transplanting whole nuclei, transplanting cell hybrids, etc.

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.

The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.

Databases containing information about NUCLEIC ACIDS such as BASE SEQUENCE; SNPS; NUCLEIC ACID CONFORMATION; and other properties. Information about the DNA fragments kept in a GENE LIBRARY or GENOMIC LIBRARY is often maintained in DNA databases.

Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.

The systematic study of the complete complement of proteins (PROTEOME) of organisms.

Facilities equipped to carry out investigative procedures.

The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.

The application of scientific knowledge to practical purposes in any field. It includes methods, techniques, and instrumentation.

The study of natural phenomena by observation, measurement, and experimentation.

The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.

Treatments with drugs which interact with or block synthesis of specific cellular components characteristic of the individual's disease in order to stop or interrupt the specific biochemical dysfunction involved in progression of the disease.

The process of pictorial communication, between human and computers, in which the computer input and output have the form of charts, drawings, or other appropriate pictorial representation.

Theoretical representations that simulate the behavior or activity of genetic processes or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.

A medical specialty concerned with the hypersensitivity of the individual to foreign substances and protection from the resultant infection or disorder.

The study of the structure, behavior, growth, reproduction, and pathology of cells; and the function and chemistry of cellular components.

Multicellular, eukaryotic life forms of kingdom Plantae (sensu lato), comprising the VIRIDIPLANTAE; RHODOPHYTA; and GLAUCOPHYTA; all of which acquired chloroplasts by direct endosymbiosis of CYANOBACTERIA. They are characterized by a mainly photosynthetic mode of nutrition; essentially unlimited growth at localized regions of cell divisions (MERISTEMS); cellulose within cells providing rigidity; the absence of organs of locomotion; absence of nervous and sensory systems; and an alternation of haploid and diploid generations.

Databases containing information about PROTEINS such as AMINO ACID SEQUENCE; PROTEIN CONFORMATION; and other properties.

The biological science concerned with the life-supporting properties, functions, and processes of living organisms or their parts.

Exclusive legal rights or privileges applied to inventions, plants, etc.

The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.

A polynucleotide consisting essentially of chains with a repeating backbone of phosphate and ribose units to which nitrogenous bases are attached. RNA is unique among biological macromolecules in that it can encode genetic information, serve as an abundant structural component of cells, and also possesses catalytic activity. (Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)

The process of cumulative change at the level of DNA; RNA; and PROTEINS, over successive generations.

That branch of learning which brings together theories and studies on communication and control in living organisms and machines.

The study of microorganisms such as fungi, bacteria, algae, archaea, and viruses.

Interacting DNA-encoded regulatory subsystems in the GENOME that coordinate input from activator and repressor TRANSCRIPTION FACTORS during development, cell differentiation, or in response to environmental cues. The networks function to ultimately specify expression of particular sets of GENES for specific conditions, times, or locations.

Therapeutic approach tailoring therapy for genetically defined subgroups of patients.

A multistage process that includes the determination of a sequence (protein, carbohydrate, etc.), its fragmentation and analysis, and the interpretation of the resulting sequence information.

RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.

Time period from 1701 through 1800 of the common era.

Biological molecules that possess catalytic activity. They may occur naturally or be synthetically created. Enzymes are usually proteins, however CATALYTIC RNA and CATALYTIC DNA molecules have also been identified.

Luciferases from BACTERIA such as PHOTOBACTERIUM; VIBRIO; and PHOTORHABDUS.

The fundamental, structural, and functional units or subunits of living organisms. They are composed of CYTOPLASM containing various ORGANELLES and a CELL MEMBRANE boundary.

Complex sets of enzymatic reactions connected to each other via their product and substrate metabolites.

Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase. cDNA (i.e., complementary DNA, not circular DNA, not C-DNA) is used in a variety of molecular cloning experiments as well as serving as a specific hybridization probe.

Research that involves the application of the natural sciences, especially biology and physiology, to medicine.

The complete genetic complement contained in a DNA or RNA molecule in a virus.

Computer processing of a language with rules that reflect and describe current usage rather than prescribed usage.

A publication issued at stated, more or less regular, intervals.

The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.

Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.

The educational process of instructing.

One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.

A process that includes the determination of AMINO ACID SEQUENCE of a protein (or peptide, oligopeptide or peptide fragment) and the information analysis of the sequence.

Theory and development of COMPUTER SYSTEMS which perform tasks that normally require human intelligence. Such tasks may include speech recognition, LEARNING; VISUAL PERCEPTION; MATHEMATICAL COMPUTING; reasoning, PROBLEM SOLVING, DECISION-MAKING, and translation of language.

The scientific disciplines concerned with the embryology, anatomy, physiology, biochemistry, pharmacology, etc., of the nervous system.

Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.

The molecular designing of drugs for specific purposes (such as DNA-binding, enzyme inhibition, anti-cancer efficacy, etc.) based on knowledge of molecular properties such as activity of functional groups, molecular geometry, and electronic structure, and also on information cataloged on analogous molecules. Drug design is generally computer-assisted molecular modeling and does not include pharmacokinetics, dosage analysis, or drug administration analysis.

The use of devices which use detector molecules to detect, investigate, or analyze other molecules, macromolecules, molecular aggregates, or organisms.

The pattern of GENE EXPRESSION at the level of genetic transcription in a specific organism or under specific circumstances in specific cells.

High molecular weight polymers containing a mixture of purine and pyrimidine nucleotides chained together by ribose or deoxyribose linkages.

The application of discoveries generated by laboratory research and preclinical studies to the development of clinical trials and studies in humans. A second area of translational research concerns enhancing the adoption of best practices.

Individuals enrolled in a school or formal educational program.

Specifications and instructions applied to the software.

Genotypic differences observed among individuals in a population.

Procedures by which protein structure and function are changed or created in vitro by altering existing or synthesizing new structural genes that direct the synthesis of proteins with sought-after properties. Such procedures may include the design of MOLECULAR MODELS of proteins using COMPUTER GRAPHICS or other molecular modeling techniques; site-specific mutagenesis (MUTAGENESIS, SITE-SPECIFIC) of existing genes; and DIRECTED MOLECULAR EVOLUTION techniques to create new genes.

Integrated set of files, procedures, and equipment for the storage, manipulation, and retrieval of information.

A course of study offered by an educational institution.

A family of North American freshwater CATFISHES. It consists of four genera (Ameiurus, Ictalurus, Noturus, Pylodictis,) comprising several species, two of which are eyeless.

Use of sophisticated analysis tools to sort through, organize, examine, and combine large sets of information.

The protein complement of an organism coded for by its genome.

Systems where the input data enter the computer directly from the point of origin (usually a terminal or workstation) and/or in which output data are transmitted directly to that terminal point of origin. (Sippl, Computer Dictionary, 4th ed)

The use of instrumentation and techniques for visualizing material and details that cannot be seen by the unaided eye. It is usually done by enlarging images, transmitted by light or electron beams, with optical or magnetic lenses that magnify the entire image field. With scanning microscopy, images are generated by collecting output from the specimen in a point-by-point fashion, on a magnified scale, as it is scanned by a narrow beam of light or electrons, a laser, a conductive probe, or a topographical probe.

Any method used for determining the location of and relative distances between genes on a chromosome.

Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.

The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.

Genes whose gain-of-function alterations lead to NEOPLASTIC CELL TRANSFORMATION. They include, for example, genes for activators or stimulators of CELL PROLIFERATION such as growth factors, growth factor receptors, protein kinases, signal transducers, nuclear phosphoproteins, and transcription factors. A prefix of "v-" before oncogene symbols indicates oncogenes captured and transmitted by RETROVIRUSES; the prefix "c-" before the gene symbol of an oncogene indicates it is the cellular homolog (PROTO-ONCOGENES) of a v-oncogene.

Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.

Partial cDNA (DNA, COMPLEMENTARY) sequences that are unique to the cDNAs from which they were derived.

The science concerned with the detection, chemical composition, and biological action of toxic substances or poisons and the treatment and prevention of toxic manifestations.

The use of molecularly targeted imaging probes to localize and/or monitor biochemical and cellular processes via various imaging modalities that include RADIONUCLIDE IMAGING; ULTRASONOGRAPHY; MAGNETIC RESONANCE IMAGING; FLUORESCENCE IMAGING; and MICROSCOPY.

Methods for determining interaction between PROTEINS.

An interdisciplinary study dealing with the transmission of messages or signals, or the communication of information. Information theory does not directly deal with meaning or content, but with physical representations that have meaning or content. It overlaps considerably with communication theory and CYBERNETICS.

Educational institutions providing facilities for teaching and research and authorized to grant academic degrees.

A multistage process that includes cloning, physical mapping, subcloning, sequencing, and information analysis of an RNA SEQUENCE.

A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.

Techniques and strategies which include the use of coding sequences and other conventional or radical means to transform or modify cells for the purpose of treating or reversing disease conditions.

A phenotypically recognizable genetic trait which can be used to identify a genetic locus, a linkage group, or a recombination event.

The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.

DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.

Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.

The addition of descriptive information about the function or structure of a molecular sequence to its MOLECULAR SEQUENCE DATA record.

A genetic process by which the adult organism is realized via mechanisms that lead to the restriction in the possible fates of cells, eventually leading to their differentiated state. Mechanisms involved cause heritable changes to cells without changes to DNA sequence such as DNA METHYLATION; HISTONE modification; DNA REPLICATION TIMING; NUCLEOSOME positioning; and heterochromatization which result in selective gene expression or repression.

Substances that inhibit or prevent the proliferation of NEOPLASMS.

Widely used technique which exploits the ability of complementary sequences in single-stranded DNAs or RNAs to pair with each other to form a double helix. Hybridization can take place between two complimentary DNA sequences, between a single-stranded DNA and a complementary RNA, or between two RNA sequences. The technique is used to detect and isolate specific sequences, measure homology, or define other characteristics of one or both strands. (Kendrew, Encyclopedia of Molecular Biology, 1994, p503)

The procedures involved in combining separately developed modules, components, or subsystems so that they work together as a complete system. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)

The prediction or projection of the nature of future problems or existing conditions based upon the extrapolation or interpretation of existing scientific data or by the application of scientific methodology.

Elements of limited time intervals, contributing to particular results or situations.

The total process by which organisms produce offspring. (Stedman, 25th ed)

A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.

Organized collections of computer records, standardized in format and content, that are stored in any of a variety of computer-readable modes. They are the basic sets of data from which computer-readable files are created. (from ALA Glossary of Library and Information Science, 1983)

The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.

A large collection of DNA fragments cloned (CLONING, MOLECULAR) from a given organism, tissue, organ, or cell type. It may contain complete genomic sequences (GENOMIC LIBRARY) or complementary DNA sequences, the latter being formed from messenger RNA and lacking intron sequences.

Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.

A set of statistical methods used to group variables or observations into strongly inter-related subgroups. In epidemiology, it may be used to analyze a closely grouped series of events or cases of disease or other health-related phenomenon with well-defined distribution patterns in relation to time or place or both.

Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing.

The study of the structure, growth, function, genetics, and reproduction of viruses, and VIRUS DISEASES.

Warm-blooded vertebrate animals belonging to the class Mammalia, including all that possess hair and suckle their young.

The assessing of academic or educational achievement. It includes all aspects of testing and test construction.

Physiological processes and properties of BACTERIA.

Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.

Conferences, conventions or formal meetings usually attended by delegates representing a special field of interest.

The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).

The chemical reactions that occur within the cells, tissues, or an organism. These processes include both the biosynthesis (ANABOLISM) and the breakdown (CATABOLISM) of organic materials utilized by the living organism.

Relatively permanent change in behavior that is the result of past experience or practice. The concept includes the acquisition of knowledge.

The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle.

Techniques used to carry out clinical investigative procedures in the diagnosis and therapy of disease.

Small double-stranded, non-protein coding RNAs, 21-25 nucleotides in length generated from single-stranded microRNA gene transcripts by the same RIBONUCLEASE III, Dicer, that produces small interfering RNAs (RNA, SMALL INTERFERING). They become part of the RNA-INDUCED SILENCING COMPLEX and repress the translation (TRANSLATION, GENETIC) of target RNA by binding to homologous 3'UTR region as an imperfect match. The small temporal RNAs (stRNAs), let-7 and lin-4, from C. elegans, are the first 2 miRNAs discovered, and are from a class of miRNAs involved in developmental timing.

Deoxyribonucleic acid that makes up the genetic material of bacteria.

Proteins found in any species of virus.

Methods utilizing the principles of MICROFLUIDICS for sample handling, reagent mixing, and separation and detection of specific components in fluids.

The complete genetic complement contained in the DNA of a set of CHROMOSOMES in a HUMAN. The length of the human genome is about 3 billion base pairs.

Extensive collections, reputedly complete, of references and citations to books, articles, publications, etc., generally on a single subject or specialized subject area. Databases can operate through automated files, libraries, or computer disks. The concept should be differentiated from DATABASES, FACTUAL which is used for collections of data and facts apart from bibliographic references to them.

The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.

The systematic identification and quantitation of all the metabolic products of a cell, tissue, organ, or organism under varying conditions. The METABOLOME of a cell or organism is a dynamic collection of metabolites which represent its net response to current conditions.

A branch of genetics which deals with the genetic variability in individual responses to drugs and drug metabolism (BIOTRANSFORMATION).

MOLECULAR BIOLOGY techniques used in the diagnosis of disease.

Biologically active DNA which has been formed by the in vitro joining of segments of DNA from different sources. It includes the recombination joint or edge of a heteroduplex region where two recombining DNA molecules are connected.

Histochemical localization of immunoreactive substances using labeled antibodies as reagents.

A general term for single-celled rounded fungi that reproduce by budding. Brewers' and bakers' yeasts are SACCHAROMYCES CEREVISIAE; therapeutic dried yeast is YEAST, DRIED.

The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.

Short tracts of DNA sequence that are used as landmarks in GENOME mapping. In most instances, 200 to 500 base pairs of sequence define a Sequence Tagged Site (STS) that is operationally unique in the human genome (i.e., can be specifically detected by the polymerase chain reaction in the presence of all other genomic sequences). The overwhelming advantage of STSs over mapping landmarks defined in other ways is that the means of testing for the presence of a particular STS can be completely described as information in a database.

Diseases that are caused by genetic mutations present during embryo or fetal development, although they may be observed later in life. The mutations may be inherited from a parent's genome or they may be acquired in utero.

A specified list of terms with a fixed and unalterable meaning, and from which a selection is made when CATALOGING; ABSTRACTING AND INDEXING; or searching BOOKS; JOURNALS AS TOPIC; and other documents. The control is intended to avoid the scattering of related subjects under different headings (SUBJECT HEADINGS). The list may be altered or extended only by the publisher or issuing agency. (From Harrod's Librarians' Glossary, 7th ed, p163)

Techniques of nucleotide sequence analysis that increase the range, complexity, sensitivity, and accuracy of results by greatly increasing the scale of operations and thus the number of nucleotides, and the number of copies of each nucleotide sequenced. The sequencing may be done by analysis of the synthesis or ligation products, hybridization to preexisting sequences, etc.

Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.

Chemical substances that are foreign to the biological system. They include naturally occurring compounds, drugs, environmental agents, carcinogens, insecticides, etc.

The development and use of techniques to study physical phenomena and construct structures in the nanoscale size range or smaller.

A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.

The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.

Specific, characterizable, poisonous chemicals, often PROTEINS, with specific biological properties, including immunogenicity, produced by microbes, higher plants (PLANTS, TOXIC), or ANIMALS.

The interactions between a host and a pathogen, usually resulting in disease.

Production of new arrangements of DNA by various mechanisms such as assortment and segregation, CROSSING OVER; GENE CONVERSION; GENETIC TRANSFORMATION; GENETIC CONJUGATION; GENETIC TRANSDUCTION; or mixed infection of viruses.

A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms.

The complete gene complement contained in a set of chromosomes in a fungus.

Established cell cultures that have the potential to propagate indefinitely.

In INFORMATION RETRIEVAL, machine-sensing or identification of visible patterns (shapes, forms, and configurations). (Harrod's Librarians' Glossary, 7th ed)

Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor genes are inactivated or lost, a barrier to normal proliferation is removed and unregulated growth is possible.

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.

Proteins found in any species of bacterium.

The reproductive organs of plants.

Theoretical representations that simulate the behavior or activity of systems, processes, or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.

Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.

A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.

A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.

ANIMALS whose GENOME has been altered by GENETIC ENGINEERING, or their offspring.

The degree of similarity between sequences. Studies of AMINO ACID SEQUENCE HOMOLOGY and NUCLEIC ACID SEQUENCE HOMOLOGY provide useful information about the genetic relatedness of genes, gene products, and species.

An operating division of the US Department of Health and Human Services. It is concerned with the overall planning, promoting, and administering of programs pertaining to health and medical research. Until 1995, it was an agency of the United States PUBLIC HEALTH SERVICE.

The parts of a macromolecule that directly participate in its specific combination with another molecule.

Ribonucleic acid that makes up the genetic material of viruses.

A species of nematode that is widely used in biological, biochemical, and genetic studies.

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.

Transplacement mutagenesis: a novel in situ mutagenesis system using phage-plasmid recombination. (1/1999)

Site-specific mutagenesis provides the ability to alter DNA with precision so that the function of any given gene can be more fully understood. Several methods of in vitro mutagenesis are time-consuming and imprecise, requiring the subcloning and sequencing of products. Here we describe a rapid, high fidelity method of in situ mutagenesis in bacteriophage lambda using transplacement. Using this method, mutations are transferred from oligonucleotides to target phages using a plasmid interface. A small (50 bp) homology region bearing a centred point mutation is generated from oligonucleotides and subcloned into a transplacement plasmid bearing positive and negative phage selectable markers. Following a positive/negative selection cycle of integrative recombination and excision, the point mutation is transferred precisely from plasmid to phage in a subset ( approximately 25-50%) of recombinants. As the fidelity of both oligonucleotide synthesis and phage-plasmid recombination is great, this approach is extremely reliable. Using transplacement, point mutations can be accurately deposited within large phage clones and we demonstrate the utility of this technique in the construction of gene targeting vectors in bacteriophages. (+info)

Conversion of lacZ enhancer trap lines to GAL4 lines using targeted transposition in Drosophila melanogaster. (2/1999)

Since the development of the enhancer trap technique, many large libraries of nuclear localized lacZ P-element stocks have been generated. These lines can lend themselves to the molecular and biological characterization of new genes. However they are not as useful for the study of development of cellular morphologies. With the advent of the GAL4 expression system, enhancer traps have a far greater potential for utility in biological studies. Yet generation of GAL4 lines by standard random mobilization has been reported to have a low efficiency. To avoid this problem we have employed targeted transposition to generate glial-specific GAL4 lines for the study of glial cellular development. Targeted transposition is the precise exchange of one P element for another. We report the successful and complete replacement of two glial enhancer trap P[lacZ, ry+] elements with the P[GAL4, w+] element. The frequencies of transposition to the target loci were 1.3% and 0.4%. We have thus found it more efficient to generate GAL4 lines from preexisting P-element lines than to obtain tissue-specific expression of GAL4 by random P-element mobilization. It is likely that similar screens can be performed to convert many other P-element lines to the GAL4 system. (+info)

Mutations in the S4 region isolate the final voltage-dependent cooperative step in potassium channel activation. (3/1999)

Charged residues in the S4 transmembrane segment play a key role in determining the sensitivity of voltage-gated ion channels to changes in voltage across the cell membrane. However, cooperative interactions between subunits also affect the voltage dependence of channel opening, and these interactions can be altered by making substitutions at uncharged residues in the S4 region. We have studied the activation of two mutant Shaker channels that have different S4 amino acid sequences, ILT (V369I, I372L, and S376T) and Shaw S4 (the S4 of Drosophila Shaw substituted into Shaker), and yet have very similar ionic current properties. Both mutations affect cooperativity, making a cooperative transition in the activation pathway rate limiting and shifting it to very positive voltages, but analysis of gating and ionic current recordings reveals that the ILT and Shaw S4 mutant channels have different activation pathways. Analysis of gating currents suggests that the dominant effect of the ILT mutation is to make the final cooperative transition to the open state of the channel rate limiting in an activation pathway that otherwise resembles that of Shaker. The charge movement associated with the final gating transition in ILT activation can be measured as an isolated component of charge movement in the voltage range of channel opening and accounts for 13% ( approximately 1.8 e0) of the total charge moved in the ILT activation pathway. The remainder of the ILT gating charge (87%) moves at negative voltages, where channels do not open, and confirms the presence of Shaker-like conformational changes between closed states in the activation pathway. In contrast to ILT, the activation pathway of Shaw S4 seems to involve a single cooperative charge-moving step between a closed and an open state. We cannot detect any voltage-dependent transitions between closed states for Shaw S4. Restoring basic residues that are missing in Shaw S4 (R1, R2, and K7) rescues charge movement between closed states in the activation pathway, but does not alter the voltage dependence of the rate-limiting transition in activation. (+info)

Probing enzyme quaternary structure by combinatorial mutagenesis and selection. (4/1999)

Genetic selection provides an effective way to obtain active catalysts from a diverse population of protein variants. We have used this tool to investigate the role of loop sequences in determining the quaternary structure of a domain-swapped enzyme. By inserting random loops of four to seven residues into a dimeric chorismate mutase and selecting for functional variants by genetic complementation, we have obtained and characterized both monomeric and hexameric enzymes that retain considerable catalytic activity. The low percentage of active proteins recovered from these selection experiments indicates that relatively few loop sequences permit a change in quaternary structure without affecting active site structure. The results of our experiments suggest further that protein stability can be an important driving force in the evolution of oligomeric proteins. (+info)

Overexpression of recombinant proteins with a C-terminal thiocarboxylate: implications for protein semisynthesis and thiamin biosynthesis. (5/1999)

A facile and rapid method for the production of protein C-terminal thiocarboxylates on DNA-encoded polypeptides is described. This method, which relies on the mechanism of the cleavage reaction of intein-containing fusion proteins, can produce multi-milligram quantities of protein C-terminal thiocarboxylate quickly and inexpensively. The utility of this method for protein semisynthesis and implications for studies on the biosynthesis of thiamin are discussed. (+info)

DnaSP version 3: an integrated program for molecular population genetics and molecular evolution analysis. (6/1999)

DnaSP is a Windows integrated software package for the analysis of the DNA polymorphism from nucleotide sequence data. DnaSP version 3 incorporates several methods for estimating the amount and pattern of DNA polymorphism and divergence, and for conducting neutrality tests. AVAILABILITY: For academic uses, DnaSP is available free of charge from: http://www.bio.ub.es/julio/DnaSP.html CONTACT: [email protected] (+info)

The molecular genetics of European ancestry. (7/1999)

In an earlier paper we proposed, on the basis of mitochondrial control region variation, that the bulk of modern European mitochondrial DNA(mtDNA) diversity had its roots in the European Upper Palaeolithic. Refining the mtDNA phylogeny and enlarging the sample size both within Europe and the Middle East still support this interpretation and indicate three separate phases of colonization: (i) the Early Upper Palaeolithic about 50,000 BP; (ii) the Late Upper Palaeolithic 11,000-14,000 BP; and (iii) the Neolithic from 8500 BP. (+info)

Molecular genetic evidence for the human settlement of the Pacific: analysis of mitochondrial DNA, Y chromosome and HLA markers. (8/1999)

Present-day Pacific islanders are thought to be the descendants of Neolithic agriculturalists who expanded from island South-east Asia several thousand years ago. They speak languages belonging to the Austronesian language family, spoken today in an area spanning half of the circumference of the world, from Madagascar to Easter Island, and from Taiwan to New Zealand. To investigate the genetic affinities of the Austronesian-speaking peoples, we analysed mitochondrial DNA, HLA and Y-chromosome polymorphisms in individuals from eight geographical locations in Asia and the Pacific (China, Taiwan, Java, New Guinea highlands, New Guinea coast, Trobriand Islands, New Britain and Western Samoa). Our results show that the demographic expansion of the Austronesians has left a genetic footprint. However, there is no simple correlation between languages and genes in the Pacific. (+info)

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As comparative molecular biology has become more common, some researchers have sought model organisms from a wider assortment ... Methods in Molecular Biology. 1462. pp. 481-519. doi:10.1007/978-1-4939-3816-2_27. ISBN 978-1-4939-3814-8. ISSN 1940-6029. PMC ... One of the first model systems for molecular biology was the bacterium Escherichia coli, a common constituent of the human ... Dictyostelium discoideum is used in molecular biology and genetics, and is studied as an example of cell communication, ...

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Molecular Biology. 39 (2): 244-252. doi:10.1007/s11008-005-0035-7. ISSN 0026-8933. S2CID 39459723. Vakhitova IuV, Iamidanov RS ... The precise direct molecular mechanism of action by which bromantane ultimately acts as a dopamine synthesis enhancer is ... doi:10.4155/bio.11.308. ISSN 1757-6180. PMID 22250799. Lionel Mandell; Mark Woodhead; Santiago Ewig; Antoni Torres (27 October ... A microdialysis study". Bulletin of Experimental Biology and Medicine. 119 (3): 294-296. doi:10.1007/BF02445840. ISSN 0007-4888 ...

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Molecular Biology. 46 (5): 639-50. doi:10.1134/S0026893312050032. PMID 23156670. S2CID 3716727. For the original version in ... Klehr - Institute for Immunology and Cell Biology] (in German). Europe Health GmbH. Archived from the original on 15 July 2015 ... However, according to Quackwatch: "The Quantum Xrroid device is claimed to balance 'bio-energetic' forces that the scientific ...

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1942-, Weaver, Robert Franklin (2012-01-01). Molecular biology. McGraw-Hill. ISBN 9780073525327. OCLC 789601172.CS1 maint: ... Molecular and Cellular Biology. 11 (9): 4669-78. doi:10.1128/mcb.11.9.4669. PMC 361357. PMID 1715023. Kaplan CD, Jin H, Zhang ... Molecular and Cellular Biology. 18 (4): 1935-45. doi:10.1128/mcb.18.4.1935. PMC 121423. PMID 9528765. "Entrez Gene: POLR2E ... Molecular Biology. 18 (12): 1394-1399. doi:10.1038/nsmb.2164. ISSN 1545-9985. PMC 3279329. PMID 22081017. Kaplan CD, Larsson KM ...

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Cell and Molecular Biology; Clinical Psychology; Genetics, Development, and Disease; Immunology; Integrative Biology; Molecular ... Researchers in developmental biology, cancer biology, and stem cell biology work on how developmental processes contribute to ... Joseph L. Goldstein, (M.D. 1966) currently Chairman of the Department of Molecular Genetics at UTSW. Malcolm Perry, (M.D. 1955 ... Goldstein is Chairman of Molecular Genetics at UT Southwestern, and Brown directs the Erik Jonsson Center for Research in ...

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Ebola and Marburg Viruses-Molecular and Cellular Biology. Wymondham Norfolciae: Horizon Bioscience. ISBN 978-0-9545232-3-7. ...

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N-myristoyltransferase 2 Molecular and Cellular Biology portal. ...

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The ketone carbon is often described as "sp2 hybridized", a description that includes both their electronic and molecular ... Many ketones are known and many are of great importance in industry and in biology. Examples include many sugars (ketoses) and ... and are more volatile than alcohols and carboxylic acids of comparable molecular weights. These factors relate to the ...

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https://en.wikipedia.org/wiki/Indinavir

... is that part of medical science that applies principles of biology, physiology, molecular biology, biophysics, and other ... Note that as used here, "biology" does not refer to the science of biology, but is a usage newly coined by NCCIH in the primary ... "Biology-based" as coined by NCCIH may refer to chemicals from a nonbiological source, such as use of the poison lead in ... "Biology"-based practices: Use substances found in nature such as herbs, foods, vitamins, and other natural substances. ( ...

https://en.wikipedia.org/wiki/Integrative_medicine

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Methods in Molecular Biology, Springer US, pp. 15-25, doi:10.1007/978-1-4939-9865-4_3, ISBN 9781493998654. , PMID 31541435. ... Methods in Molecular Biology, Springer US, 2072, pp. 15-25, doi:10.1007/978-1-4939-9865-4_3, ISBN 9781493998654. , PMID ... QTLs are mapped by identifying which molecular markers (such as SNPs or AFLPs) correlate with an observed trait. This is often ...

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Chemtracts - Biochemistry and Molecular Biology. 11:933-943 *^ a b c Svedberg, T. (1927). The Ultracentrifuge Nobel Lecture ... it had exactly the same molecular weight.[11][12] How something of such a large molecular mass could be consistently found, ... Current Opinion in Chemical Biology, Vol. 10, 2006. pp. 430-436.. *Dam, J., Velikovsky, C.A., Mariuzza R.A., et al. ... hemoglobin has a molecular weight of 68,000 Da, suggesting that there are four iron atoms present rather than one, and that no ...

https://en.m.wikipedia.org/wiki/Centrifugation

Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley- ... Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins ( ... Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). ...

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Molecular and therapeutic aspects of redox biochemistry (2004). *An illustrated guide to the flora of Mauritius and the Indian ... Gurib-Fakim, A.; Sewraj, M.; J., Gueho; Dulloo, E.. «Medicinal Plants of Rodrigues». Pharmaceutical Biology. doi:10.1076/phbi. ... Gurib-Fakim, A.; Gueho, J.; Sewraj-Bissoondoyal, M.. «The Medicinal Plants of Mauritius - Part 1». Pharmaceutical Biology. doi: ... Pharmaceutical Biology. doi:10.1076/phbi.36.3.153.6345. ... Pharmaceutical Biology. doi:10.1076/phbi.37.3.202.6300. ...

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... where he is a full professor of cell and molecular biology and head of the Center for Protein Chemistry of Hemocentro de ... Greene received a BA in liberal arts from Amherst College in 1955 and a PhD in biochemistry and cell biology at Rockefeller ... After his doctorate, he went to work for 12 years as a tenured researcher in the Department of Biology at Brookhaven National ...

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The software has been cited in thousands of scientific molecular biology publications and is one of several tools for systems ... and is purchased by QIAGEN in May of the same year Systems biology Bioinformatics Computational genomics Computational biology ... "Best of Show: Life Science Software & Informatics". Bio-IT World. June 13, 2007. Retrieved April 7, 2012. "Ingenuity Systems ... "Best of Show Award Winners Named at the Fifteenth International Molecular Medicine Tri-Conference" (Press release). Cambridge ...

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Molecular cell biology. 4th ed, New York: Scientific American Books. ISBN 0716731363 ... Kimball's biology pages, Cell membranes *↑ Singleton P, (1999). Bacteria in biology, biotechnology and medicine (5th ed.). New ...

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"PLoS Biology. 6 (8): e202. doi:10.1371/journal.pbio.0060202. PMC 2517622. PMID 18715117.. ... Molecular Phylogenetics and Evolution. 65 (2): 562-572. doi:10.1016/j.ympev.2012.07.011. PMID 22842292.. ... Molecular Phylogenetics and Evolution. 29 (2): 250-257. doi:10.1016/S1055-7903(03)00096-4. PMID 13678680.. ... Journal of Avian Biology. 49 (2): 1-14. doi:10.1111/jav.01612.. ...

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Molecular Biology and Evolution". 22 (9), s. 1869-86, 09-2005. DOI: 10.1093/molbev/msi180. PMID: 15930153 (ang.). ... Molecular Phylogenetics and Evolution". 1 (2), s. 148-146, 1992. DOI: 10.1016/1055-7903(92)90026-D. PMID: 1342928 (ang.). ... A molecular phylogeny for bats illuminates biogeography and the fossil record. „Science". 307 (5709), s. 580-4, 01-2005. DOI: ... Integrated fossil and molecular data reconstruct bat echolocation. „Proceedings of the National Academy of Sciences of the ...

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PubMed Identifier,PMID]] 16712999] Molecular and Cellular Biology portal. ... Microbial degradation of styrene: biochemistry, molecular genetics, and perspectives for biotechnological applications. Appl. ...

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Avery's work marked the birth of the molecular era of genetics.[14] ... advances in next-generation sequencing and comparative genomics have enabled the development of robust and reliable molecular ...

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PET and SPECT are capable of detecting areas of molecular biology detail (even prior to anatomic change). PET scanning does ... "Magnetic Resonance Materials in Physics, Biology and Medicine. 26 (1): 99-113. doi:10.1007/s10334-012-0353-4. ISSN 0968-5243. ... 2003). "11C-metomidate PET imaging of adrenocortical cancer". European Journal of Nuclear Medicine and Molecular Imaging. 30 (3 ... Crump Institute for Molecular Imaging. Archived from the original (PDF) on May 18, 2015.. ...

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"School of Biology, Georgia Institute of Technology. Retrieved 12 March 2017.. *. Geneve, Robert. "Leaf" (PDF). PLS 220: ... On the basis of molecular genetics, Eckardt and Baum (2010) concluded that "it is now generally accepted that compound leaves ... "PLoS Computational Biology. 4 (4): e1000055. arXiv:0705.0902. Bibcode:2008PLSCB...4E0055L. doi:10.1371/journal.pcbi.1000055. ... "Basic Biology. Adam Purcell. Retrieved 17 February 2017.. *. Simpson, Michael G. "Plants of San Diego County, California". ...

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Klenk, Hans-Dieter; Feldmann, Heinz (2004). Ebola and Marburg viruses: molecular and cellular biology (Limited preview). ... The Biology, Circumstances and Consequences of Cross-Species Transmission. Current Topics in Microbiology and Immunology. ... Trends in Molecular Medicine. 12 (5): 206-15. doi:10.1016/j.molmed.2006.03.006. PMID 16616875.. ...

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Karaoglu D, Kelleher DJ, Gilmore R (October 2001). "Allosteric regulation provides a molecular mechanism for preferential ... Marquardt T, Denecke J (June 2003). "Congenital disorders of glycosylation: review of their molecular bases, clinical ...

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By Ben Bradbury-Koster May 26th, 2021 in Student News Four BMB undergraduates were inducted into the Tri-Alpha Honor Society this year. Tri-Alpha honors first-gen students who have achieved high GPAs of… More. ...

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Biology presents original research contributions on the utilization of molecular imaging in problems of relevance in biology ... Molecular Imaging and Biology is the official journal of the World Molecular Imaging Society and the European Society for ... Molecular Imaging and Biology presents original research contributions on the utilization of molecular imaging in problems of ... Molecular Imaging and Biology is ranked #15 in the Google Scholar H-5 Index of Nuclear Medicine and Radiotherapy, with a 2019 H ...

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I've always been fascinated by molecular mechanisms of biological processes, and this is the best place to learn more about that. (asbmb.org)
Molecular biology / m ə ˈ l ɛ k j ʊ l ər / is the branch of biology that concerns the molecular basis of biological activity in and between cells , including molecular synthesis, modification, mechanisms and interactions. (wikipedia.org)
Molecular biology arose as an attempt to answer the questions regarding the mechanisms of genetic inheritance and the structure of a gene . (wikipedia.org)
The primary objective of the journal is to provide a forum for the discovery of molecular mechanisms of health and disease through the use of imaging techniques. (springer.com)
The Unit of Molecular Biology of Diseases is seeking a talented and highly motivated post-doctoral candidate in order to explore the molecular and cellular mechanisms underlying tumor development and progression. (nature.com)
This course is designed to give students an opportunity learn on the some of the many molecular mechanisms of diseases caused by novel alleles, while not losing sight of other causes, in particular emergent infectious agents. (columbia.edu)
Offered as BIOL 251 and BCBP 281) A study of the molecular mechanisms underlying the transmission and expression of genes. (amherst.edu)
An analysis of the molecules and molecular mechanisms underlying nervous system function, development, and disease. (amherst.edu)
We will also study the molecular mechanisms that control brain development, from neurogenesis, neurite growth and synaptogenesis to cell death and degeneration. (amherst.edu)
In addition to analyzing neural function, throughout the course we will also study nervous system dysfunction resulting when such molecular mechanisms fail, leading to neurodevelopmental and neurodegenerative disease. (amherst.edu)
The Developmental Oncogene Laboratory seeks to characterize the molecular mechanisms and normal or oncogenic functions of genes that play important roles during development but also contribute to cancer in the adult. (csun.edu)
You will learn about the relationships between the structure and function of proteins and nucleic acids, and the molecular mechanisms behind immunology, genetic engineering and Cancer. (york.ac.uk)
Researchers in computational biology and bioinformatics develop algorithms that can predict the behavior of a biological system and explore the molecular mechanisms of function of nucleic acids and/or proteins. (umassmed.edu)
The Schiffer group uses molecular dynamics, detailed structural analysis, sequence analysis and structure based drug design to elucidate the molecular mechanisms by which mutations confer drug resistance and to develop strategies for avoiding drug resistance. (umassmed.edu)
The Kelch lab uses molecular dynamics simulations and molecular modeling approaches to determine the structures and mechanisms of large complicated macromolecular machines. (umassmed.edu)
The Weng lab is a leading analytical member of the ENCODE and psychENCODE consortia and has determined molecular mechanisms of gene regulation as well as how genetic variations in the human population affect gene regulation and susceptibility for diseases. (umassmed.edu)
Specific research interests of the independent groups are interconnected by a common interest in fundamental and translational research concerning the molecular mechanisms of both bacterial and eukaryotic systems. (umu.se)
Describe the molecular mechanisms that regulate gene expression, including epigenetics. (unibo.it)
Describe the molecular mechanisms of cell fate determination and differentiation. (unibo.it)
The broad goals of this research is to understand the cellular, molecular and genetic mechanisms that drive immunologically-mediated disorders. (cincinnatichildrens.org)
This research increases our general knowledge of these processes and their molecular mechanisms, which is also of major importance for our understanding of a number of diseases. (ruc.dk)
Students successfully completing this module should have developed a conceptual understanding of several aspects of Molecular Biology and Biochemistry, relevant for molecular mechanisms of disease. (bangor.ac.uk)
A study of the molecular mechanisms by which cellular processes are controlled in prokaryotic and eukaryotic cells. (western.edu)
Molecular biology is the study of the molecular underpinnings of the biological phenomena, focusing on molecular synthesis, modification, mechanisms and interactions. (wikipedia.org)

In order to better understand and assess the quality of ground and spring water, state-of-the-art methods from the fields of molecular biology and microbiology, as well as chemical high-performance analytics are now developed. (news-medical.net)
This incubator supports a wide diversity of tissue, cell, and microbiological cultures and experiment methods to meet any spaceflight research experiment goals and objectives, including cell biology, microbiology, discovery biology, and drug-testing studies to be conducted on the ISS. (nasa.gov)
This degree will give you a broad ranging knowledge of the molecular biosciences by allowing you to combine elements from our biochemistry, genetics and microbiology courses. (sheffield.ac.uk)
At Saint Mary's this discipline is covered in several upper division laboratory courses including Molecular Biology, Genetics, Microbiology, Immunology and Cell Biology after a firm introduction in our introductory course, Biology 1. (stmarys-ca.edu)
You will acquire a solid understanding of all the key theories of biochemistry, cell biology, genetics and microbiology. (ruc.dk)
Umeå University hosts many prominent research groups conducting strategic molecular research of international significance within areas of microbiology, cell biology, chemical biology, genetic model organisms, immunology, systems biology, sensory systems, cancer biology, developmental biology, medical biology and immunology. (umu.se)
Specific entry requirements are: a) 60 ECTS in the Bioscience area (including genetics, microbiology, cell biology, molecular biology, zoo physiology and plant biology) and also including a minimum of 7.5 ECTS in each of Genetics and Microbiology. (umu.se)
Our fascinating BSc courses and accredited MBiolSci degrees span the bioscience subjects of biochemistry, genetics, microbiology and molecular biology. (sheffield.ac.uk)

JBC publishes high-quality science that seeks to elucidate the molecular and cellular basis of biological processes. (asbmb.org)
The overall goal is to translate basic science discoveries into molecular imaging of disease in patients, both to investigate the biological nature of disease in actual patients and to establish new molecular imaging diagnostic procedures. (springer.com)
Molecular analysis of virus genomes can be separated into two types of approach: physical analysis of structure and nucleotide sequence performed in vitro , and a more biological method to examine the structure-function relationships of intact virus genomes and individual genetic elements, generally involving analysis of the virus phenotype in vivo . (news-medical.net)
Announcing a Workshop on Methods in Molecular Biology at Oregon State University 1996 Offered by the Molecular and Cellular Biology Program Oregon State University Corvallis, Oregon (541) 737-3799 An intensive training course for graduate students, faculty and researchers in the biological and medical sciences The methods of molecular biology, in particular recombinant DNA work, have transformed research in the biological and medical sciences. (bio.net)
This course provides a hands-on introduction to molecular biological methods. (bio.net)
Molecular Biological Investigations of Pheromone Desaturases, PBAN regulation of pheromone biosynthesis in female moths. (elsevier.com)
This course is ideal for students who have an interest in studying biological systems at the molecular and cellular levels, encompassing areas that are at the forefront of biomedicine and biotechnology today. (york.ac.uk)
The goal of computational biology and bioinformatics is to understand biology through the development of mathematical models, the use of computer simulation techniques and statistical analysis of large biological data-sets. (umassmed.edu)
One of the current grand challenges in biology is bridging the gap between detailed gene/interaction lists and phenotypic, systems-level behaviors of biological networks. (ucl.ac.uk)
Molecular Environmental Biology is the first book to illustrate molecular biological approaches to major issues in environmental biology. (routledge.com)
Specific topics discussed include the use of molecular techniques in the population biology of wild animals and in the management of fisheries, bioremediation, cloning and characterization of the genes responsible for degradation of PCBs and related environmental pollutants, molecular analysis of aromatic hydrocarbon degradation by soil bacteria, and molecular biological techniques in assessing environmental damage to natural habitats. (routledge.com)
Topics discussed in this area include an introduction to molecular epidemiology, the uses of molecular biological markers in cancer risk assessment, specific environmental carcinogens found in foods, measuring DNA adducts and mutation frequencies to assess environmental toxic exposures and effect, and using the extent of gene inducibility as a dosimeter of toxic exposure. (routledge.com)
While this material may be omitted from a basic cell biology course, serving as optimal or supplementary reading, it represents an essential part of our knowledge about cells and should be especially useful to those who decide to continue with biological or medical studies. (nih.gov)
The broad coverage expresses our conviction that cell biology should be at the center of a modern biological education. (nih.gov)
The Center for Computational Molecular Biology (CCMB) promotes the development, implementation and application of analytical and computational methods to foundational questions in the biological and medical sciences. (brown.edu)
ASBMB publishes three journals: the Journal of Biological Chemistry, Journal of Lipid Research and Molecular and Cellular Proteomics. (asbmb.org)
Since its origin in 1972, the department of Molecular Biology has made major contributions to the development of molecular biological technology for fundamental and applied research. (wur.nl)
In the Master's programme in Molecular Biology you acquire an extensive toolbox for investigating all kinds of biological problems with advanced molecular methods. (umu.se)
Molecular systems biology aims at understanding of biological phenomena based on the quantitative analysis of chemical and physical processes at the molecular level. (deds.nl)
By its very nature, systems biology is a highly interdisciplinary approach towards understanding complex biological processes. (deds.nl)
Molecular biology / m ə ˈ l ɛ k j ʊ l ər / is a branch of biology that concerns the molecular basis of biological activity between biomolecules in the various systems of a cell , including the interactions between DNA , RNA , proteins and their biosynthesis , as well as the regulation of these interactions. (wikipedia.org)
Today the logical approach and tools of biochemical science are being expanded to new areas in neuroscience, developmental biology, immunology, pharmacology and synthetic biology (the design of analogs of biological systems). (brown.edu)
Demonstrate a competence in performing common molecular biological techniques (pipetting, dilution, setting up enzymatic reactions, polymerase chain reaction, gel electrophoresis, data recording and analysis) Demonstrate appropriate numerical and descriptive data analysis skills. (bangor.ac.uk)
Knowledge of theoretical and practical molecular biology is necessary to understand and create new knowledge in biotechnology and biological and medical science. (uib.no)
Molecular biology is also important for developing good data tools for the analysis of biological data. (uib.no)
Molecular Biology belongs to the Department of Biological Sciences (BIO), which is situated on the Marineholmen campus close to the city centre. (uib.no)
The focus of the Chemical Biology specialty section is on molecules and methods used to identify, visualize, probe or validate the biological functions of small molecules or biomolecules and their biological pathways. (frontiersin.org)
Chemical Biology covers advances in a wide range of topics in the field, from new molecular tools and techniques, to their applications to address biological questions at the molecular or cellular level. (frontiersin.org)

Molecular genetics and recombinant DNA technology for the manipulation of genes. (edu.au)
Reiter JF, Leroux MR. Genes and molecular pathways underpinning ciliopathies. (sfu.ca)
This course builds on MOL221 , Experimental molecular biology I. In MOL222 students will follow laboratory protocols to perform molecular cloning of two protein-coding genes followed by their mammalian cell expression and analysis using immuno-detection and microscopy techniques. (uib.no)
Even though Molecular Biology is an elusive term and therefore a difficult field of study to define, here at Saint Mary's, we enjoy simplicity, and choose to define it classically, as the study of the structure and activity of genes at the molecular level. (stmarys-ca.edu)
Molecular Biology is the part of biology that concerns itself with macromolecules' properties and interactions, and examines the function of genes and the function of the proteins that are formed. (ruc.dk)
In molecular and cellular biology, traditional research is dedicated to unravel acute functional relevance of proteins and genes, as well as mechanistic insights into their long-term role in signal transduction. (umcutrecht.nl)
Topics include the biochemistry of macromolecular processes, the structure of genes and chromosomes, the genetic and molecular techniques used to study gene expression, and the transcriptional and translational control of gene expression. (western.edu)
Genetics attempts to predict how mutations, individual genes and genetic interactions can affect the expression of a phenotype While researchers practice techniques specific to molecular biology, it is common to combine these with methods from genetics and biochemistry. (wikipedia.org)

Plant Molecular Biology is an international journal dedicated to rapid publication of original research in all areas of plant biology. (springer.com)
The Laboratory of Molecular Biology has several research groups that are active at different areas of plant molecular biology. (wur.nl)
For example, you can take courses in Biochemistry, Infection Biology or Plant Molecular Biology. (umu.se)

Honours qualifies a person for normal membership of professional bodies such as Australian Society for Medical Research , Australasian Society for Immunology and The Australian Society for Biochemistry and Molecular Biology . (edu.au)

The American Society for Biochemistry and Molecular Biology helps you excel at all stages of your scientific career through networking, professional development, meetings, journals and leadership opportunities. (asbmb.org)
The Biology and Biochemistry and Molecular Biology Chairs (or faculty designate) will inform the MCB Graduate Program Director of the 'target' number of Program students expected to be funded by Biology and BMB TAs. (umass.edu)
Insect Pheromone Biochemistry and Molecular Biology covers how insects produce pheromones and how they detect pheromones and plant volatiles. (elsevier.com)
In MOL222 , the students will get theoretical and practical introduction to important methods and techniques in biochemistry and molecular biology. (uib.no)
Centre's program in biochemistry and molecular biology (BMB) is designed to provide a solid introduction to the cellular and molecular fundamentals of life. (centre.edu)
he Department of Biochemistry and Molecular Biology offers a program of study leading to the Ph.D. degree. (gradschools.com)
This question is at the core of the concentration program Biochemistry and Molecular Biology. (brown.edu)

Molecular Imaging and Biology is ranked #15 in the Google Scholar H-5 Index of Nuclear Medicine and Radiotherapy, with a 2019 H-5 Index of 31. (springer.com)

When you become an ASBMB member, you join more than 11,000 scientists worldwide working to advance scientific discovery in the molecular life sciences. (asbmb.org)
Founded in 1974, EMBL is Europe's flagship laboratory for the life sciences - an intergovernmental organisation with more than 80 independent research groups covering the spectrum of molecular biology. (embl.de)
Sidney Frank Hall of Life Sciences is a five-story, 169,000-square-foot glass and brick structure devoted to the study of human biology and the Laboratory of Molecular Medicine that houses laboratories of faculty drawn from five basic science departments of the Brown Medical School, and two cutting edge research centers. (brown.edu)

Newly revised and updated, the Fourth Edition is a comprehensive guide through the basic molecular processes and genetic phenomena of both prokaryotic and eukaryotic cells. (google.com)
The Use of Molecular Genetic Techniques to Address Conservation Questions (M.W. Bruford and R.K. Wayne). (routledge.com)
The central dogma of molecular biology where genetic material is transcribed into RNA and then translated into protein , despite being oversimplified, still provides a good starting point for understanding the field. (wikipedia.org)

Molecular biology is the study of the molecular underpinnings of the processes of replication , transcription , translation , and cell function. (wikipedia.org)
Based on the results of these selection processes, the Biology and BMB Chairs (or faculty designate) match the wishes of the instructors and TAs as far as possible and circulate tentative assignments. (umass.edu)
BMC Biochemistry is an open access, peer-reviewed journal that considers articles on all aspects of biochemical processes, including the structure, function and dynamics of metabolic pathways, supramolecular complexes, enzymes, proteins, nucleic acids and small molecular components of organelles, cells and tissues. (biomedcentral.com)
We will explore the proteins that contribute to the unique structure and function of neurons, including an in-depth analysis of synaptic communication and the molecular processes that modify synapses. (amherst.edu)
Oncogenic animal viruses harness the network through diverse molecular processes that promote ErbB signalling or prevent it from being switched off. (nature.com)
Their research programs aim to understand fundamental processes of plant biology and to use this fundamental knowledge in applied projects. (wur.nl)
Systems biology analyses and integrates complex molecular processes. (deds.nl)

Much of molecular biology is quantitative, and recently a significant amount of work has been done using computer science techniques such as bioinformatics and computational biology . (wikipedia.org)
What is Computational Biology and Bioinformatics ? (umassmed.edu)
The BMP department has expertise in many different areas, and computational biology and bioinformatics are key or central components for many of our studies. (umassmed.edu)
Furthermore, students will get hands-on experience in the usage of bioinformatics tools for molecular cloning and will learn the physical and chemical basis of the related analytical methods. (uib.no)
Much of molecular biology is quantitative, and recently much work has been done at its interface with computer science in bioinformatics and computational biology . (wikipedia.org)

This book offers an introduction to mathematical concepts and techniques needed for the construction and interpretation of models in molecular systems biology. (mit.edu)
We are delighted to announce that Molecular Systems Biology continues its progression, with an Impact Factor 2008 of 12.243. (nature.com)
The RECOMB Satellite on Regulatory Genomics, RECOMB Satellite on Systems Biology, and DREAM reverse engineering conferences are currently held jointly at the MIT, in Boston. (nature.com)
Systems biology approaches involve quantitative modeling of molecular systems. (deds.nl)
This iterative approach combining modeling and wet lab experiments is typical for systems biology. (deds.nl)
Professor Henry Heng's team, from the medical school at Wayne State University, has published a perspective article titled A Systems Biology Perspective on Molecular Cytogenetics to address the issue. (eurekalert.org)
In this article, they applied the genome theory to explain why cytogenetics/cytogenomics needs a systems biology perspective, while systems biology itself needs a cytogenetic/cytogenomic based platform, since genome context (karyotype) represents a new type of genomic coding. (eurekalert.org)
Thus, systems biology should not exclusively focus on parts collection, but study how to predict system behavior at the proper genomic levels: the understanding of lower-level parts has very limited power to understand the emergence at higher system levels when the entire system is highly complex. (eurekalert.org)
The integration of cytogenetics/cytogenomics with systems biology will mutually benefit both fields. (eurekalert.org)

This course is one of a range of courses in the molecular biosciences offered by the Department of Molecular Biology and Biotechnology. (sheffield.ac.uk)
With a Master of Science Degree in Molecular Biology you are attractive for employers at, for example, pharmaceutical and biotechnology companies, usually within research, development or marketing. (umu.se)
The Department of Biochemistry & Molecular Biology offers programs leading to MS, PhD, and MD/PhD degrees, preparing students for successful careers as independent investigators in academia, government, biotechnology, and in teaching in academia, govern. (gradschools.com)
A background in cell and molecular biology will prepare you for a variety of careers in the growing field of biotechnology, where you can help develop new medications, treatments and breakthrough research. (western.edu)
Through this dynamic blend of coursework, you'll gain the foundation you need to pursue a career in biotechnology and advanced degrees in laboratory biology, medicine, veterinary medicine, dentistry, pharmacy and physician assistantships. (western.edu)

Some clinical research and medical therapies arising from molecular biology are covered under gene therapy whereas the use of molecular biology or molecular cell biology in medicine is now referred to as molecular medicine . (wikipedia.org)
Molecular biology also plays important role in understanding formations, actions, and regulations of various parts of cells which can be used to efficiently target new drugs , diagnose disease, and understand the physiology of the cell. (wikipedia.org)
Other branches of biology are informed by molecular biology, by either directly studying the interactions of molecules in their own right such as in cell biology and developmental biology , or indirectly, where molecular techniques are used to infer historical attributes of populations or species , as in fields in evolutionary biology such as population genetics and phylogenetics . (wikipedia.org)
Nuclear function, cytoskeleton and cell membrane interactions, transport of cellular products between different organelles fits in the Cellular Biology category. (springer.com)
Molecular Cell 2004). (nature.com)
Systems techniques are integral to current research in molecular cell biology, and system-level investigations are often accompanied by mathematical models. (mit.edu)
This new web focus from Cell Death & Differentiation, Cell Death & Disease and Cell Death Discovery highlights some of the latest research from China in the related fields covered by those journals, including cell death, stem cells, autophagy, and tumor biology. (biomedcentral.com)
Molecular biology chiefly concerns itself with understanding the interactions between the various systems of a cell, including the interactions between DNA, RNA and protein biosynthesis as well as learning how these interactions are regulated. (news-medical.net)
ATCC offers a variety of nucleic acid preparations from our Bacteriology, Mycology, Protistology, Virology, and Cell Biology collections. (atcc.org)
The Bio-Chip Space-Lab provides an accessible platform that enables academic and industry researchers to perform long-term automated cell culturing experiments with live-cell imaging in the unique microgravity environment onboard the International Space Station. (nasa.gov)
With its acclaimed author team, cutting-edge content, and coverage based on landmark experiments, Molecular Cell Biology has earned an impeccable reputation with instructors. (worldcat.org)
Cell and Molecular Space Biology Researchers conduct experiments that help develop an understanding of the ways cells (or parts of cells) function and respond to spaceflight. (nasa.gov)
In a study funded by a NASA Space Biology grant researchers sent cultures of mouse embryonic stem cells into low earth orbit for 15 days on the STS-131 mission to follow the progress of stem cell differentiation, both while in space and then in culture back in normal gravity on earth. (nasa.gov)
Previous research conducted by Space Biology investigators revealed that the stem cell mechanism that controls bone growth is weakened in microgravity. (nasa.gov)
The goal of this site is to develop and maintain an online informational resource for cell and molecular biologists that provides links to resources for research, education and community. (merlot.org)
You just viewed Cell and Molecular Biology Online . (merlot.org)
The project will therefore expose the student to a range of cutting-edge cell biology techniques in labs that are leading in this field. (york.ac.uk)
Our Molecular Cell Biology course focuses on providing a molecular understanding of life. (york.ac.uk)
This course is ideal if you want an interdisciplinary approach to Molecular Cell Biology. (york.ac.uk)
Dr. Shigeo Ohta is a professor from Department of Biochemistry and Cell Biology, Nippon Medical School. (springer.com)
The department of Molecular Cell Biology (MCB) strives to elucidate how the integration of molecular structure, function, and behavior can lead to a functional living cell. (vu.nl)
The central theme of the Department of Molecular Cell Biology is how molecules by dynamical organisation and interaction create life. (vu.nl)
V. V. Artym, A. L. Kindzelskii, W. T. Chen, and H. R. Petty, "Molecular proximity of seprase and the urokinase-type plasminogen activator receptor on malignant melanoma cell membranes: dependence on β 1 integrins and the cytoskeleton," Carcinogenesis , vol. 23, no. 10, pp. 1593-1602, 2002. (hindawi.com)
The presence of cholesterol and glycolipids, which are found in most cell membranes, can also affect molecular dynamics and inhibit phase transitions. (fsu.edu)
The Massi lab has determined the molecular origin of the order/disorder transition in the TIS11 family of RNA-binding proteins and characterized how this structural transition affects the activity of these proteins in the cell. (umassmed.edu)
Our laboratory was established in 2013 to undertake research combining cell biology, optical physics and biochemistry. (ucl.ac.uk)
In cell biology we aim to understand how viruses enter cells, probing and remodelling membranes, and what are the structural changes viruses undergo during cell-entry, uncoating and morphogenesis. (ucl.ac.uk)
To do so, we are developing new classes of fluorescent probes, high-speed cell friendly Super-Resolution (SR) methods and computational modelling approaches that, although designed to answer questions of interest in the lab, will have broad applications in cell biology research. (ucl.ac.uk)
The overarching goal of our lab is to develop technology broadly applicable to research in cell biology. (ucl.ac.uk)
Biology (Sci) : The physical and chemical properties of the cell and its components in relation to their structure and function. (mcgill.ca)
Trends in Cell Biology. (sfu.ca)
Molecular Cell. (sfu.ca)
Read a description of the Laboratory of Cell and Molecular Biology . (nih.gov)
Read a description of the Structural Cell Biology Section . (nih.gov)
for Plant Molecular & Cell. (upv.es)
Seeing (stem) cell biology with the eyes of Physics: perspective for a Regenerative Medicine without the needs for cell or tissue transplantation. (unibo.it)
Molecular Biology of the Cell is chiefly concerned with eucaryotic cells, as opposed to bacteria, and its title reflects the prime importance of the insights that have come from the molecular approach. (nih.gov)
Part I and Part II of the book analyze cells from this perspective and cover the traditional material of cell biology courses. (nih.gov)
Thus developmental biology, histology, immunobiology, and neurobiology are discussed at much greater length than in other cell biology textbooks. (nih.gov)
Before I carry on with a summary of the second part of the Keystone Symposium 'Omics Meets Cell Biology', I should clarify that this post and the previous one dedicated to this conference are not intended to provide an comprehensive account of all the talks but rather to communicate some general (and subjective) impressions of the meeting. (nature.com)
At the Keystone Symposium 'OMICS Meets Cell Biology', held this week in Breckenridge, Colorado, attendees had initially to face two major challenges: the first was to survive the cocktail mixing jet lag and altitude sickness and the second one-oh, it hurts! (nature.com)
Welcome to the Department of Molecular Biology, Cell Biology & Biochemistry (MCB), which is the largest on-campus department in the Division of Biology and Medicine. (brown.edu)
The Department is devoted to cutting-edge research that addresses basic questions in biology, including the control of gene expression, cell fate determination, protein synthesis, the genetics of behavior, control of the cell cycle, and signaling pathways within the cell. (brown.edu)
In this lecture, we're going to talk about molecular biology structures, by which I mean structures in the DNA and other molecules inside the cell that you need to know about to understand the rest of the course. (coursera.org)
So these are mostly terms and, and descriptions of functions that, that go on inside every cell of your body that kind of govern how, how, how you're molecular, how molecular biology works and how genetics works. (coursera.org)
In the junior and senior years, students progress from macromolecules to cellular metabolism to molecular genetics to cell biology. (centre.edu)
Researchers at Lawrence Berkeley National Laboratory and UC Berkeley have combined cutting-edge cryo-electron microscopy (cryo-EM) with computational molecular modeling to produce a near atomic-resolution model of the interaction between microtubules - crucial components of eukaryotic cell ultrastructure - and microtubule-associated proteins called tau. (lbl.gov)
The Department of Cell Biology offers graduate training in cell biology and physiology leading to the Ph.D. degree. (gradschools.com)
The department is closely associated with the interdepartmental Program in Cell and Molecular Biology, and many of the department's gradu. (gradschools.com)
Molecular & Cell Biology incorporates the Comparative Genomics Centre and is one of the most research-active departments at James Cook University. (edu.au)
An active seminar program that brings distinguished scientists from Australia and overseas to JCU is another unique feature of Molecular & Cell Biology, and the Honours and graduate students benefit immensely from this activity. (edu.au)
Molecular & Cell Biology has a very strong commitment to research and the students who have completed Honours have had no difficulty in finding employment or Ph.D. positions at JCU or other campuses. (edu.au)
Candidature for honours in Molecular & Cell Biology requires successful completion of a full major in Molecular & Cell Biology with grades of at least a credit average. (edu.au)
The Cell & Molecular Biology curriculum focuses on courses in advanced cell biology, molecular genetics and biochemistry. (western.edu)
An introduction to experimentation and laboratory techniques used in cell biology,physiology, and genetics, including experimental design, data analysis, and presentation of research results. (western.edu)

To help molecular biologists specifically identify each strand individually, the two strands are usually differentiated as the "sense" strand and the "antisense" strand. (wikipedia.org)
In addition, daily lectures by molecular biologists will provide theoretical background and insight into cutting-edge research developments and techniques. (bio.net)
Medical, pharmaceutical and biotechnological industry and research are also relevant fields of work for molecular biologists. (uib.no)

Laboratories for Molecular Medicine (LMM) houses the other half of MCB labs along with the Genomics Core Facility, Structural Biology Core Facility, & the Transgenic Mouse Facility. (brown.edu)
The Center of Computational Molecular Biology and the Center for Genomics and Proteomics. (brown.edu)
This course introduces you to the basic biology of modern genomics and the experimental tools that we use to measure it. (coursera.org)

The new field of Artificial Chemistries draws from chemistry, biology, computer science, mathematics, and other disciplines to work toward that goal. (mit.edu)
The field overlaps with other areas of biology and chemistry, particularly genetics and biochemistry. (news-medical.net)
Requisite: Biology 19 and Chemistry 12. (amherst.edu)
The BMB major begins in the first-year/sophomore years with a solid foundation in biology, chemistry, mathematics, and physics. (centre.edu)
You can do your project either in a research group at Umeå University, for example in the departments of Molecular Biology, Chemistry or Plant Physiology, but other arrangements with research intense organisations like biotech companies are also possible. (umu.se)
Training in biochemistry begins with a foundation in mathematics, physics, chemistry and biology. (brown.edu)
Faculty sponsors are drawn from both the Chemistry Department and the Division of Biology and Medicine, and include basic science and clinical faculty. (brown.edu)
It is an interdisciplinary section devoted to all aspects of chemical biology, a rapidly growing field at the interface of chemistry and biology as well as related biomedical fields. (frontiersin.org)

NSQAP works with other programs in the NSMBB: the Biochemical Mass Spectrometry Laboratory, the Newborn Screening Translation Research Laboratory, and the Molecular Quality Improvement Program. (cdc.gov)

Staff: Dr. Katharine Field, Coordinator Dr. Walt Ream, co-coordinator Dr. Gary Merrill, co-coordinator Faculty of the Molecular and Cellular Biology Program Housing: Housing in studio 'quad' apartments (single rooms with shared kitchen and bath) is available close to campus at a cost of $185 for two weeks. (bio.net)
The Department of Molecular Biology is unique, being affiliated to both the Faculty of Science and Technology and to the Faculty of Medicine. (umu.se)
The research programs of the Core Faculty in CCMB lie fundamentally at the intersection of computer science, evolutionary biology, mathematics, and molecular and cellular biology. (brown.edu)
Welcome to master's studies in Molecular biology at the Faculty of Mathematics and Natural Sciences. (uib.no)

The Molecular & Developmental Biology Graduate Program at Cincinnati Children's Hospital Medical Center offers a unique opportunity to participate in cutting-edge research while being embedded in one of the top three pediatric hospitals in the nation. (cincinnatichildrens.org)

The Massi group uses computer simulations to understand the fundamental aspects of molecular recognition and binding specificity of RNA binding proteins that regulate the stability of mRNA transcripts encoding key cancer-related proteins. (umassmed.edu)

[1] [2] The central dogma of molecular biology describes the process in which DNA is transcribed into RNA then translated into protein. (wikipedia.org)
We'll introduce the Central Dogma of Molecular Biology and cover how next-generation sequencing can be used to measure DNA, RNA, and epigenetic patterns. (coursera.org)

As a master's student in molecular biology you will spend your first year doing coursework (60 ECTS) and your second year working in the lab, and on writing your master's thesis (60 ECTS). (uib.no)

This collection describes key approaches in sparse modeling, focusing on its applications in fields including neuroscience, computational biology, and computer vision. (mit.edu)
We will study the functional consequences of b1 processing on gene expression using molecular approaches such as chromatin immunoprecipitation (ChIP). (york.ac.uk)
The book also explores how new molecular approaches can be applied to human disease etiology and epidemiology. (routledge.com)
Molecular Epidemiologic Approaches in Environmental Carcinogenesis (R.M. Santella and F.P. Perera). (routledge.com)
Research in our department employs a range of cross-disciplinary approaches, including state of the art optical tools for confocal and electron microscopy, physical technologies such as X-ray diffraction, and innovative techniques in molecular biology. (brown.edu)

Consequently all Biology majors gain significant experience in the techniques and practice of hands-on work in molecular biology, or "molecular genetics' as it is often called. (stmarys-ca.edu)
It has been well recognized that the use of basic reagents of highest purity is a definite prerequisite for successful work in molecular biology. (sigmaaldrich.com)

While researchers practice techniques specific to molecular biology, it is common to combine these with methods from genetics and biochemistry . (wikipedia.org)
The Basic Molecular Biology eLearning Series provides online training for public health and clinical laboratory professionals by introducing the scientific background for molecular diagnosis, the principles of molecular biology laboratory practice, and common methods. (cdc.gov)
The introduction of high-throughput methods has transformed biology into a data-rich science. (mit.edu)
Application of modern molecular methods to biomedical and agricultural problems will also be considered. (amherst.edu)
Schedule: MCB 525 - Methods in Molecular Biology Session 1 July 15 - July 27, 1996 Session 2 September 9 - September 21, 1996 This is a highly intensive training course, requiring a full-time committment from the participants. (bio.net)
International experts have contributed representative chapters that cover how molecular methods and concepts apply to wildlife management, ecology, pollution control and remediation, and environmental health. (routledge.com)
Products belonging to the quality grade BioUltra for molecular biology are wellsuited for all commonly used basic experimental methods in the field of molecular cloning. (sigmaaldrich.com)

In the first year, you'll take a broad-based programme that covers a range of areas in the molecular biosciences. (sheffield.ac.uk)

For patterning networks, molecular ensembles must sense and transduce spatial information such as position, direction and distance, which requires integrating information over length scales orders of magnitude larger than the molecules themselves. (ucl.ac.uk)

The Kelch Lab recently used molecular modeling to produce a structural model of an exceptionally powerful DNA motor used in viruses to package their genomes. (umassmed.edu)
Receive email alerts on new books, offers and news in Molecular biology, biochemistry, and structural biology. (cambridge.org)

The following list describes a viewpoint on the interdisciplinary relationships between molecular biology and other related fields. (wikipedia.org)

Our studies examine DNA function and structure, cellular and molecular changes, phenotypic changes to organisms, as well as the ability of eukaryotic cells to generate and maintain their complex internal cyto-architecture integral to the regulation of both growth and form. (nasa.gov)

Recent research in molecular biology has produced a remarkably detailed understanding of how living things operate. (mit.edu)

To meet the increasing demand for such high purity reagents used in gene technology experiments, we introduced a specific BioUltra quality grade: BioUltra for molecular biology. (sigmaaldrich.com)

Molecular Epidemiology of Common Diseases (K. Hemminki). (routledge.com)
Molecular biology has invaluable contributions to the understanding of diseases, including HIV, cancers, diabetes and prionic diseases. (uib.no)

Molecular Biology Reports publishes original research papers and review articles that demonstrate novel molecular and cellular findings in both eukaryotes (animals, plants, algae, funghi) and prokaryotes (bacteria and archaea).The journal publishes results of both fundamental and translational research as well as new techniques that advance experimental progress in the field and presents original research papers, short communications and (mini-) reviews. (springer.com)
The purpose of the course is to provide solid basic knowledge and skills in experimental molecular biology techniques and in scientific communication thus establishing the basis for further studies in molecular biology. (uib.no)
We offer a wide range of undergraduate and graduate courses that form the core of modern experimental biology. (brown.edu)
At the same time, these junior-senior BMB courses introduce the student to most of the major experimental tools that are critical to this molecular understanding of life. (centre.edu)
The laboratory exercises entail modern experimental techniques to solve relevant questions in Molecular Biology. (umu.se)

This volume of Molecular Biology of Hematopoiesis is dedicated to many inter- national scientists and clinicians for their contribution to the field of Hematology/ Oncology presented at the 11th International Symposium on Molecular Biology of Hematopoiesis, which was held in Bormio, Italy, June 25-29, 1998. (springer.com)
Hematopoiesis, molecular biology, and molecular oncology including mouse modeling of hematopoiesis, myelopoiesis and leukemia. (cincinnatichildrens.org)

In this review, we describe the most recent discoveries in the molecular and cellular biology of RMS, including alterations in oncogenic pathways, miRNA (miR), in vivo models, stem cells, and important signal transduction cascades implicated in the development and progression of RMS. (hindawi.com)

BMC Molecular Biology is an open access journal publishing original peer-reviewed research articles in all aspects of DNA and RNA in a cellular context, encompassing investigations of chromatin, replication, recombination, mutation, repair, transcription, translation and RNA processing and function. (biomedcentral.com)
The module also contains 6 practical days on applied molecular methodologies covering a range of key technologies (reverse transcription, PCR, agarose gel electrophoresis, protein expression and SDS-PAGE). (bangor.ac.uk)
and the development of molecular probes to identify and characterize potential therapeutic targets, such as enzymes, receptors, transcription factors, nucleic acids, and others, and their use in drug discovery. (frontiersin.org)

Molecular genetics , the study of gene structure and function, has been among the most prominent sub-fields of molecular biology since the early 2000s. (wikipedia.org)

The Department of Biology will provide you with the opportunity to learn in new, spacious and modern teaching laboratories which provide excellent facilities for practicals and small group project work, alongside our state-of-the-art computing facilities. (york.ac.uk)
The graduate program in the Department of Biology provides students with the training they need to excel in academic or biomedical research careers. (gradschools.com)

All of our undergraduate courses are accredited by the Royal Society of Biology . (york.ac.uk)

The four-year MBiolSci has Advanced Accreditation from the Royal Society of Biology, has more focus on laboratory skills, and includes an extensive research project, which can be based in a university or industrial lab. (sheffield.ac.uk)
The following year he moved to Harvard University, where he became Professor of Biology, a post he held until 1976. (google.com)
Molecular Biology is a subject which you will study as a part of your bachelor programme at Roskilde University. (ruc.dk)
Master's projects in Molecular Biology cover a wide professional range and are carried out in different research groups and departments at the university but also at the University Hospital and Institute of Marine Research. (uib.no)
With a master's degree in molecular biology you can work with research and teaching at universities, university colleges, university hospitals and other major hospitals. (uib.no)

ATCC is a trusted and reliable resource for molecular tools with a variety of vectors, hosts and expression tools for molecular research. (atcc.org)
The BioToolKit, a searchable and browsable database of 400 internet research applications, includes up-to-date links to nucleic acid, genome, and protein databases, online applications for data retrieval and data analysis, and tools for molecular visualization. (bio.net)

In molecular biology and genetics , the sense of a nucleic acid molecule, particularly of a strand of DNA or RNA , refers to the nature of the roles of the strand and its complement in specifying a sequence of amino acids . (wikipedia.org)
The basic Molecular Biology series includes four eLearning courses: Basic Science, Laboratory Practice, Nucleic Acid Extraction, and PCR and Real-Time PCR. (cdc.gov)

The MCB Graduate Program Director informs the Biology and BMB Chairs of the names of students he wishes to have TA support. (umass.edu)

One of the most basic techniques of molecular biology to study protein function is molecular cloning . (wikipedia.org)
This basic-level eLearning course provides information on the fundamental characteristics of DNA and RNA, nucleotide base-pairing rules, and the basic techniques and workflow applied in molecular diagnostics. (cdc.gov)
Readings from primary literature will emphasize current molecular techniques utilized in the study of the nervous system. (amherst.edu)
Readers will find information on new techniques and applications of established molecular methodology that will stimulate new research ideas, collaborations, and progress. (routledge.com)
Researchers in molecular biology use specific techniques native to molecular biology but increasingly combine these with techniques and ideas from genetics and biochemistry . (wikipedia.org)

The Molecular, Cellular & Physiological Biology Area is proud of its many lab classes and the connection to biomedical research. (csun.edu)
Importantly, our biomedical research probes the molecular basis of several human disorders arising from ciliary dysfunction, including Bardet-Biedl Syndrome and Meckel syndrome. (sfu.ca)

Anatomy4

Organisms10

Diseases7

Chemicals and Drugs25

Analytical, Diagnostic and Therapeutic Techniques and Equipment44

Psychiatry and Psychology1

Phenomena and Processes60

Disciplines and Occupations32

Anthropology, Education, Sociology and Social Phenomena9

Technology, Industry, Agriculture4

Humanities5

Information Science37

Named Groups1

Health Care11

Transplacement mutagenesis: a novel in situ mutagenesis system using phage-plasmid recombination. (1/1999)

Conversion of lacZ enhancer trap lines to GAL4 lines using targeted transposition in Drosophila melanogaster. (2/1999)

Mutations in the S4 region isolate the final voltage-dependent cooperative step in potassium channel activation. (3/1999)

Probing enzyme quaternary structure by combinatorial mutagenesis and selection. (4/1999)

Overexpression of recombinant proteins with a C-terminal thiocarboxylate: implications for protein semisynthesis and thiamin biosynthesis. (5/1999)

DnaSP version 3: an integrated program for molecular population genetics and molecular evolution analysis. (6/1999)

The molecular genetics of European ancestry. (7/1999)

Molecular genetic evidence for the human settlement of the Pacific: analysis of mitochondrial DNA, Y chromosome and HLA markers. (8/1999)

Molecular Biology

Biology

Systems Biology

Developmental Biology

Computational Biology

History, 20th Century

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Internet

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Models, Biological

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Databases, Genetic

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Information Storage and Retrieval

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History, 19th Century

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Forensic Sciences

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User-Computer Interface

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Cell Physiological Phenomena

DNA

Societies, Scientific

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Genome

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Genetic Engineering

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Terminology as Topic

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Evolution, Molecular

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