Directories as Topic
Molecular Sequence Data
Human Genome Project
Gene Expression Profiling
Sequence Analysis, DNA
Information Storage and Retrieval
Polymerase Chain Reaction
Amino Acid Sequence
Database Management Systems
Oligonucleotide Array Sequence Analysis
Gene Expression Regulation
Terminology as Topic
Databases, Nucleic Acid
Molecular Targeted Therapy
Allergy and Immunology
Gene Regulatory Networks
Metabolic Networks and Pathways
Natural Language Processing
Clinical Trials as Topic
Sequence Analysis, Protein
Molecular Probe Techniques
Translational Medical Research
Reproducibility of Results
Disease Models, Animal
Expressed Sequence Tags
Sequence Analysis, RNA
Reverse Transcriptase Polymerase Chain Reaction
Molecular Sequence Annotation
Nucleic Acid Hybridization
Sensitivity and Specificity
Databases as Topic
Cell Transformation, Neoplastic
Congresses as Topic
Clinical Laboratory Techniques
Microfluidic Analytical Techniques
Protein Structure, Tertiary
Sequence Tagged Sites
Genetic Diseases, Inborn
High-Throughput Nucleotide Sequencing
Tumor Markers, Biological
Pattern Recognition, Automated
Genes, Tumor Suppressor
Gene Expression Regulation, Neoplastic
Genetic Predisposition to Disease
Animals, Genetically Modified
National Institutes of Health (U.S.)
Transplacement mutagenesis: a novel in situ mutagenesis system using phage-plasmid recombination. (1/1999)Site-specific mutagenesis provides the ability to alter DNA with precision so that the function of any given gene can be more fully understood. Several methods of in vitro mutagenesis are time-consuming and imprecise, requiring the subcloning and sequencing of products. Here we describe a rapid, high fidelity method of in situ mutagenesis in bacteriophage lambda using transplacement. Using this method, mutations are transferred from oligonucleotides to target phages using a plasmid interface. A small (50 bp) homology region bearing a centred point mutation is generated from oligonucleotides and subcloned into a transplacement plasmid bearing positive and negative phage selectable markers. Following a positive/negative selection cycle of integrative recombination and excision, the point mutation is transferred precisely from plasmid to phage in a subset ( approximately 25-50%) of recombinants. As the fidelity of both oligonucleotide synthesis and phage-plasmid recombination is great, this approach is extremely reliable. Using transplacement, point mutations can be accurately deposited within large phage clones and we demonstrate the utility of this technique in the construction of gene targeting vectors in bacteriophages. (+info)
Conversion of lacZ enhancer trap lines to GAL4 lines using targeted transposition in Drosophila melanogaster. (2/1999)Since the development of the enhancer trap technique, many large libraries of nuclear localized lacZ P-element stocks have been generated. These lines can lend themselves to the molecular and biological characterization of new genes. However they are not as useful for the study of development of cellular morphologies. With the advent of the GAL4 expression system, enhancer traps have a far greater potential for utility in biological studies. Yet generation of GAL4 lines by standard random mobilization has been reported to have a low efficiency. To avoid this problem we have employed targeted transposition to generate glial-specific GAL4 lines for the study of glial cellular development. Targeted transposition is the precise exchange of one P element for another. We report the successful and complete replacement of two glial enhancer trap P[lacZ, ry+] elements with the P[GAL4, w+] element. The frequencies of transposition to the target loci were 1.3% and 0.4%. We have thus found it more efficient to generate GAL4 lines from preexisting P-element lines than to obtain tissue-specific expression of GAL4 by random P-element mobilization. It is likely that similar screens can be performed to convert many other P-element lines to the GAL4 system. (+info)
Mutations in the S4 region isolate the final voltage-dependent cooperative step in potassium channel activation. (3/1999)Charged residues in the S4 transmembrane segment play a key role in determining the sensitivity of voltage-gated ion channels to changes in voltage across the cell membrane. However, cooperative interactions between subunits also affect the voltage dependence of channel opening, and these interactions can be altered by making substitutions at uncharged residues in the S4 region. We have studied the activation of two mutant Shaker channels that have different S4 amino acid sequences, ILT (V369I, I372L, and S376T) and Shaw S4 (the S4 of Drosophila Shaw substituted into Shaker), and yet have very similar ionic current properties. Both mutations affect cooperativity, making a cooperative transition in the activation pathway rate limiting and shifting it to very positive voltages, but analysis of gating and ionic current recordings reveals that the ILT and Shaw S4 mutant channels have different activation pathways. Analysis of gating currents suggests that the dominant effect of the ILT mutation is to make the final cooperative transition to the open state of the channel rate limiting in an activation pathway that otherwise resembles that of Shaker. The charge movement associated with the final gating transition in ILT activation can be measured as an isolated component of charge movement in the voltage range of channel opening and accounts for 13% ( approximately 1.8 e0) of the total charge moved in the ILT activation pathway. The remainder of the ILT gating charge (87%) moves at negative voltages, where channels do not open, and confirms the presence of Shaker-like conformational changes between closed states in the activation pathway. In contrast to ILT, the activation pathway of Shaw S4 seems to involve a single cooperative charge-moving step between a closed and an open state. We cannot detect any voltage-dependent transitions between closed states for Shaw S4. Restoring basic residues that are missing in Shaw S4 (R1, R2, and K7) rescues charge movement between closed states in the activation pathway, but does not alter the voltage dependence of the rate-limiting transition in activation. (+info)
Probing enzyme quaternary structure by combinatorial mutagenesis and selection. (4/1999)Genetic selection provides an effective way to obtain active catalysts from a diverse population of protein variants. We have used this tool to investigate the role of loop sequences in determining the quaternary structure of a domain-swapped enzyme. By inserting random loops of four to seven residues into a dimeric chorismate mutase and selecting for functional variants by genetic complementation, we have obtained and characterized both monomeric and hexameric enzymes that retain considerable catalytic activity. The low percentage of active proteins recovered from these selection experiments indicates that relatively few loop sequences permit a change in quaternary structure without affecting active site structure. The results of our experiments suggest further that protein stability can be an important driving force in the evolution of oligomeric proteins. (+info)
Overexpression of recombinant proteins with a C-terminal thiocarboxylate: implications for protein semisynthesis and thiamin biosynthesis. (5/1999)A facile and rapid method for the production of protein C-terminal thiocarboxylates on DNA-encoded polypeptides is described. This method, which relies on the mechanism of the cleavage reaction of intein-containing fusion proteins, can produce multi-milligram quantities of protein C-terminal thiocarboxylate quickly and inexpensively. The utility of this method for protein semisynthesis and implications for studies on the biosynthesis of thiamin are discussed. (+info)
DnaSP version 3: an integrated program for molecular population genetics and molecular evolution analysis. (6/1999)DnaSP is a Windows integrated software package for the analysis of the DNA polymorphism from nucleotide sequence data. DnaSP version 3 incorporates several methods for estimating the amount and pattern of DNA polymorphism and divergence, and for conducting neutrality tests. AVAILABILITY: For academic uses, DnaSP is available free of charge from: http://www.bio.ub.es/julio/DnaSP.html CONTACT: [email protected] (+info)
The molecular genetics of European ancestry. (7/1999)In an earlier paper we proposed, on the basis of mitochondrial control region variation, that the bulk of modern European mitochondrial DNA(mtDNA) diversity had its roots in the European Upper Palaeolithic. Refining the mtDNA phylogeny and enlarging the sample size both within Europe and the Middle East still support this interpretation and indicate three separate phases of colonization: (i) the Early Upper Palaeolithic about 50,000 BP; (ii) the Late Upper Palaeolithic 11,000-14,000 BP; and (iii) the Neolithic from 8500 BP. (+info)
Molecular genetic evidence for the human settlement of the Pacific: analysis of mitochondrial DNA, Y chromosome and HLA markers. (8/1999)Present-day Pacific islanders are thought to be the descendants of Neolithic agriculturalists who expanded from island South-east Asia several thousand years ago. They speak languages belonging to the Austronesian language family, spoken today in an area spanning half of the circumference of the world, from Madagascar to Easter Island, and from Taiwan to New Zealand. To investigate the genetic affinities of the Austronesian-speaking peoples, we analysed mitochondrial DNA, HLA and Y-chromosome polymorphisms in individuals from eight geographical locations in Asia and the Pacific (China, Taiwan, Java, New Guinea highlands, New Guinea coast, Trobriand Islands, New Britain and Western Samoa). Our results show that the demographic expansion of the Austronesians has left a genetic footprint. However, there is no simple correlation between languages and genes in the Pacific. (+info)
Neoplasm refers to an abnormal growth of cells that can be benign (non-cancerous) or malignant (cancerous). Neoplasms can occur in any part of the body and can affect various organs and tissues. The term "neoplasm" is often used interchangeably with "tumor," but while all tumors are neoplasms, not all neoplasms are tumors.
Types of Neoplasms
There are many different types of neoplasms, including:
1. Carcinomas: These are malignant tumors that arise in the epithelial cells lining organs and glands. Examples include breast cancer, lung cancer, and colon cancer.
2. Sarcomas: These are malignant tumors that arise in connective tissue, such as bone, cartilage, and fat. Examples include osteosarcoma (bone cancer) and soft tissue sarcoma.
3. Lymphomas: These are cancers of the immune system, specifically affecting the lymph nodes and other lymphoid tissues. Examples include Hodgkin lymphoma and non-Hodgkin lymphoma.
4. Leukemias: These are cancers of the blood and bone marrow that affect the white blood cells. Examples include acute myeloid leukemia (AML) and chronic lymphocytic leukemia (CLL).
5. Melanomas: These are malignant tumors that arise in the pigment-producing cells called melanocytes. Examples include skin melanoma and eye melanoma.
Causes and Risk Factors of Neoplasms
The exact causes of neoplasms are not fully understood, but there are several known risk factors that can increase the likelihood of developing a neoplasm. These include:
1. Genetic predisposition: Some people may be born with genetic mutations that increase their risk of developing certain types of neoplasms.
2. Environmental factors: Exposure to certain environmental toxins, such as radiation and certain chemicals, can increase the risk of developing a neoplasm.
3. Infection: Some neoplasms are caused by viruses or bacteria. For example, human papillomavirus (HPV) is a common cause of cervical cancer.
4. Lifestyle factors: Factors such as smoking, excessive alcohol consumption, and a poor diet can increase the risk of developing certain types of neoplasms.
5. Family history: A person's risk of developing a neoplasm may be higher if they have a family history of the condition.
Signs and Symptoms of Neoplasms
The signs and symptoms of neoplasms can vary depending on the type of cancer and where it is located in the body. Some common signs and symptoms include:
1. Unusual lumps or swelling
4. Weight loss
5. Change in bowel or bladder habits
6. Unexplained bleeding
7. Coughing up blood
8. Hoarseness or a persistent cough
9. Changes in appetite or digestion
10. Skin changes, such as a new mole or a change in the size or color of an existing mole.
Diagnosis and Treatment of Neoplasms
The diagnosis of a neoplasm usually involves a combination of physical examination, imaging tests (such as X-rays, CT scans, or MRI scans), and biopsy. A biopsy involves removing a small sample of tissue from the suspected tumor and examining it under a microscope for cancer cells.
The treatment of neoplasms depends on the type, size, location, and stage of the cancer, as well as the patient's overall health. Some common treatments include:
1. Surgery: Removing the tumor and surrounding tissue can be an effective way to treat many types of cancer.
2. Chemotherapy: Using drugs to kill cancer cells can be effective for some types of cancer, especially if the cancer has spread to other parts of the body.
3. Radiation therapy: Using high-energy radiation to kill cancer cells can be effective for some types of cancer, especially if the cancer is located in a specific area of the body.
4. Immunotherapy: Boosting the body's immune system to fight cancer can be an effective treatment for some types of cancer.
5. Targeted therapy: Using drugs or other substances to target specific molecules on cancer cells can be an effective treatment for some types of cancer.
Prevention of Neoplasms
While it is not always possible to prevent neoplasms, there are several steps that can reduce the risk of developing cancer. These include:
1. Avoiding exposure to known carcinogens (such as tobacco smoke and radiation)
2. Maintaining a healthy diet and lifestyle
3. Getting regular exercise
4. Not smoking or using tobacco products
5. Limiting alcohol consumption
6. Getting vaccinated against certain viruses that are associated with cancer (such as human papillomavirus, or HPV)
7. Participating in screening programs for early detection of cancer (such as mammograms for breast cancer and colonoscopies for colon cancer)
8. Avoiding excessive exposure to sunlight and using protective measures such as sunscreen and hats to prevent skin cancer.
It's important to note that not all cancers can be prevented, and some may be caused by factors that are not yet understood or cannot be controlled. However, by taking these steps, individuals can reduce their risk of developing cancer and improve their overall health and well-being.
1) They share similarities with humans: Many animal species share similar biological and physiological characteristics with humans, making them useful for studying human diseases. For example, mice and rats are often used to study diseases such as diabetes, heart disease, and cancer because they have similar metabolic and cardiovascular systems to humans.
2) They can be genetically manipulated: Animal disease models can be genetically engineered to develop specific diseases or to model human genetic disorders. This allows researchers to study the progression of the disease and test potential treatments in a controlled environment.
3) They can be used to test drugs and therapies: Before new drugs or therapies are tested in humans, they are often first tested in animal models of disease. This allows researchers to assess the safety and efficacy of the treatment before moving on to human clinical trials.
4) They can provide insights into disease mechanisms: Studying disease models in animals can provide valuable insights into the underlying mechanisms of a particular disease. This information can then be used to develop new treatments or improve existing ones.
5) Reduces the need for human testing: Using animal disease models reduces the need for human testing, which can be time-consuming, expensive, and ethically challenging. However, it is important to note that animal models are not perfect substitutes for human subjects, and results obtained from animal studies may not always translate to humans.
6) They can be used to study infectious diseases: Animal disease models can be used to study infectious diseases such as HIV, TB, and malaria. These models allow researchers to understand how the disease is transmitted, how it progresses, and how it responds to treatment.
7) They can be used to study complex diseases: Animal disease models can be used to study complex diseases such as cancer, diabetes, and heart disease. These models allow researchers to understand the underlying mechanisms of the disease and test potential treatments.
8) They are cost-effective: Animal disease models are often less expensive than human clinical trials, making them a cost-effective way to conduct research.
9) They can be used to study drug delivery: Animal disease models can be used to study drug delivery and pharmacokinetics, which is important for developing new drugs and drug delivery systems.
10) They can be used to study aging: Animal disease models can be used to study the aging process and age-related diseases such as Alzheimer's and Parkinson's. This allows researchers to understand how aging contributes to disease and develop potential treatments.
Explanation: Neoplastic cell transformation is a complex process that involves multiple steps and can occur as a result of genetic mutations, environmental factors, or a combination of both. The process typically begins with a series of subtle changes in the DNA of individual cells, which can lead to the loss of normal cellular functions and the acquisition of abnormal growth and reproduction patterns.
Over time, these transformed cells can accumulate further mutations that allow them to survive and proliferate despite adverse conditions. As the transformed cells continue to divide and grow, they can eventually form a tumor, which is a mass of abnormal cells that can invade and damage surrounding tissues.
In some cases, cancer cells can also break away from the primary tumor and travel through the bloodstream or lymphatic system to other parts of the body, where they can establish new tumors. This process, known as metastasis, is a major cause of death in many types of cancer.
It's worth noting that not all transformed cells will become cancerous. Some forms of cellular transformation, such as those that occur during embryonic development or tissue regeneration, are normal and necessary for the proper functioning of the body. However, when these transformations occur in adult tissues, they can be a sign of cancer.
See also: Cancer, Tumor
Word count: 190
These disorders are caused by changes in specific genes that fail to function properly, leading to a cascade of effects that can damage cells and tissues throughout the body. Some inherited diseases are the result of single gene mutations, while others are caused by multiple genetic changes.
Inherited diseases can be diagnosed through various methods, including:
1. Genetic testing: This involves analyzing a person's DNA to identify specific genetic changes that may be causing the disease.
2. Blood tests: These can help identify certain inherited diseases by measuring enzyme levels or identifying specific proteins in the blood.
3. Imaging studies: X-rays, CT scans, and MRI scans can help identify structural changes in the body that may be indicative of an inherited disease.
4. Physical examination: A healthcare provider may perform a physical examination to look for signs of an inherited disease, such as unusual physical features or abnormalities.
Inherited diseases can be treated in various ways, depending on the specific condition and its causes. Some treatments include:
1. Medications: These can help manage symptoms and slow the progression of the disease.
2. Surgery: In some cases, surgery may be necessary to correct physical abnormalities or repair damaged tissues.
3. Gene therapy: This involves using genes to treat or prevent inherited diseases.
4. Rehabilitation: Physical therapy, occupational therapy, and other forms of rehabilitation can help individuals with inherited diseases manage their symptoms and improve their quality of life.
Inherited diseases are a significant public health concern, as they affect millions of people worldwide. However, advances in genetic research and medical technology have led to the development of new treatments and management strategies for these conditions. By working with healthcare providers and advocacy groups, individuals with inherited diseases can access the resources and support they need to manage their conditions and improve their quality of life.
Explanation: Genetic predisposition to disease is influenced by multiple factors, including the presence of inherited genetic mutations or variations, environmental factors, and lifestyle choices. The likelihood of developing a particular disease can be increased by inherited genetic mutations that affect the functioning of specific genes or biological pathways. For example, inherited mutations in the BRCA1 and BRCA2 genes increase the risk of developing breast and ovarian cancer.
The expression of genetic predisposition to disease can vary widely, and not all individuals with a genetic predisposition will develop the disease. Additionally, many factors can influence the likelihood of developing a particular disease, such as environmental exposures, lifestyle choices, and other health conditions.
Inheritance patterns: Genetic predisposition to disease can be inherited in an autosomal dominant, autosomal recessive, or multifactorial pattern, depending on the specific disease and the genetic mutations involved. Autosomal dominant inheritance means that a single copy of the mutated gene is enough to cause the disease, while autosomal recessive inheritance requires two copies of the mutated gene. Multifactorial inheritance involves multiple genes and environmental factors contributing to the development of the disease.
Examples of diseases with a known genetic predisposition:
1. Huntington's disease: An autosomal dominant disorder caused by an expansion of a CAG repeat in the Huntingtin gene, leading to progressive neurodegeneration and cognitive decline.
2. Cystic fibrosis: An autosomal recessive disorder caused by mutations in the CFTR gene, leading to respiratory and digestive problems.
3. BRCA1/2-related breast and ovarian cancer: An inherited increased risk of developing breast and ovarian cancer due to mutations in the BRCA1 or BRCA2 genes.
4. Sickle cell anemia: An autosomal recessive disorder caused by a point mutation in the HBB gene, leading to defective hemoglobin production and red blood cell sickling.
5. Type 1 diabetes: An autoimmune disease caused by a combination of genetic and environmental factors, including multiple genes in the HLA complex.
Understanding the genetic basis of disease can help with early detection, prevention, and treatment. For example, genetic testing can identify individuals who are at risk for certain diseases, allowing for earlier intervention and preventive measures. Additionally, understanding the genetic basis of a disease can inform the development of targeted therapies and personalized medicine."
Disease progression can be classified into several types based on the pattern of worsening:
1. Chronic progressive disease: In this type, the disease worsens steadily over time, with a gradual increase in symptoms and decline in function. Examples include rheumatoid arthritis, osteoarthritis, and Parkinson's disease.
2. Acute progressive disease: This type of disease worsens rapidly over a short period, often followed by periods of stability. Examples include sepsis, acute myocardial infarction (heart attack), and stroke.
3. Cyclical disease: In this type, the disease follows a cycle of worsening and improvement, with periodic exacerbations and remissions. Examples include multiple sclerosis, lupus, and rheumatoid arthritis.
4. Recurrent disease: This type is characterized by episodes of worsening followed by periods of recovery. Examples include migraine headaches, asthma, and appendicitis.
5. Catastrophic disease: In this type, the disease progresses rapidly and unpredictably, with a poor prognosis. Examples include cancer, AIDS, and organ failure.
Disease progression can be influenced by various factors, including:
1. Genetics: Some diseases are inherited and may have a predetermined course of progression.
2. Lifestyle: Factors such as smoking, lack of exercise, and poor diet can contribute to disease progression.
3. Environmental factors: Exposure to toxins, allergens, and other environmental stressors can influence disease progression.
4. Medical treatment: The effectiveness of medical treatment can impact disease progression, either by slowing or halting the disease process or by causing unintended side effects.
5. Co-morbidities: The presence of multiple diseases or conditions can interact and affect each other's progression.
Understanding the type and factors influencing disease progression is essential for developing effective treatment plans and improving patient outcomes.
There are several types of chromosome aberrations, including:
1. Chromosomal deletions: Loss of a portion of a chromosome.
2. Chromosomal duplications: Extra copies of a chromosome or a portion of a chromosome.
3. Chromosomal translocations: A change in the position of a chromosome or a portion of a chromosome.
4. Chromosomal inversions: A reversal of a segment of a chromosome.
5. Chromosomal amplifications: An increase in the number of copies of a particular chromosome or gene.
Chromosome aberrations can be detected through various techniques, such as karyotyping, fluorescence in situ hybridization (FISH), or array comparative genomic hybridization (aCGH). These tests can help identify changes in the chromosomal makeup of cells and provide information about the underlying genetic causes of disease.
Chromosome aberrations are associated with a wide range of diseases, including:
1. Cancer: Chromosome abnormalities are common in cancer cells and can contribute to the development and progression of cancer.
2. Birth defects: Many birth defects are caused by chromosome abnormalities, such as Down syndrome (trisomy 21), which is caused by an extra copy of chromosome 21.
3. Neurological disorders: Chromosome aberrations have been linked to various neurological disorders, including autism and intellectual disability.
4. Immunodeficiency diseases: Some immunodeficiency diseases, such as X-linked severe combined immunodeficiency (SCID), are caused by chromosome abnormalities.
5. Infectious diseases: Chromosome aberrations can increase the risk of infection with certain viruses, such as human immunodeficiency virus (HIV).
6. Ageing: Chromosome aberrations have been linked to the ageing process and may contribute to the development of age-related diseases.
7. Radiation exposure: Exposure to radiation can cause chromosome abnormalities, which can increase the risk of cancer and other diseases.
8. Genetic disorders: Many genetic disorders are caused by chromosome aberrations, such as Turner syndrome (45,X), which is caused by a missing X chromosome.
9. Rare diseases: Chromosome aberrations can cause rare diseases, such as Klinefelter syndrome (47,XXY), which is caused by an extra copy of the X chromosome.
10. Infertility: Chromosome abnormalities can contribute to infertility in both men and women.
Understanding the causes and consequences of chromosome aberrations is important for developing effective treatments and improving human health.
SPINE (molecular biology)
Vector (molecular biology)
Plant Molecular Biology
Chimera (molecular biology)
Complementarity (molecular biology)
Molecular Membrane Biology
Molecular Systems Biology
NASBA (molecular biology)
Molecular Biology Reports
Primer (molecular biology)
Sense (molecular biology)
Ligation (molecular biology)
Insert (molecular biology)
Directionality (molecular biology)
Molecular Biology (journal)
TILLING (molecular biology)
Methods in Molecular Biology
European Molecular Biology Laboratory
Molecular and Cellular Biology
Institute of Molecular Biology
Molecular Biology and Evolution
Molecular Imaging and Biology
European Molecular Biology Organization
Nature Structural & Molecular Biology
Mutagenesis (molecular biology technique)
History of molecular biology
Journal of Molecular Biology
Cell and molecular biology
MRC Laboratory of Molecular Biology
Uridine monophosphate synthase
Prostaglandin-endoperoxide synthase 2
Ian A. Graham
New Delhi metallo-beta-lactamase 1
Methionine synthase) reductase
List of restriction enzyme cutting sites: Bst-Bv
Proto-oncogene tyrosine-protein kinase Src
Rhomboid-related protein 2
Newborn Screening and Molecular Biology Branch | CDC
Molecular & Structural Biology
CSIBD Annual Molecular Biology Course
Binita Basukala | Molecular Biology, Cell Biology & Biochemistry Program
p53 in health and disease | Nature Reviews Molecular Cell Biology
Dr. Jasmin Lalonde | Molecular and Cellular Biology
Molecular Marine Biology
Directory Detail | Molecular and Cell Biology
William Hsiao - Department of Molecular Biology and Biochemistry - Simon Fraser University
Study Molecular Biology and Biotechnology (Bachelor) ✔ TU Dresden
Syllabus for Trends in Molecular Biology and Biotechnology - Uppsala University, Sweden
Victor Busov | Biochemistry and Molecular Biology-PhD | Michigan Tech
Nature Reviews Molecular Cell Biology - Wikipedia bahasa Indonesia, ensiklopedia bebas
Molecular, Cell and Developmental Biology | indivfaculty
Ammonium acetate BioUltra, for molecular biology, 5M water 631-61-8
Honors and Distinctions: Molecular and Cell Biology and Genetics - Drexel University College of Medicine
Meet Ora Rosen, Who Solved Insulin's Secrets and Galvanized Molecular Biology | Sloan Kettering Institute
Cold Spring Harbor Lab Press Molecular Biology
Cold Spring Harbor Lab Press Molecular Biology
Proposing 5-Steps Rule Is a Notable Milestone for Studying Molecular Biology
Coronaviruses: Molecular and Cellular Biology - Volume 14, Number 4-April 2008 - Emerging Infectious Diseases journal - CDC
Research Focus: Max Planck Institute of Molecular Cell Biology and Genetics
SciELO - Genetics and Molecular Biology, Volume: 32, Issue: 1, Published: 2009
Molecular and cellular biology | Stanford Libraries
MRC Laboratory of Molecular Biology - UKRI
Mathivanan - Exosomes, secretome and systems biology, La Trobe Institute for Molecular Science (LIMS), La Trobe University
- Each summer, the Center for the Study of Inflammatory Bowel Disease offers a Current Techniques in Molecular Genetics course for CSIBD members as well as their staff and trainees. (massgeneral.org)
- This course focuses on the use of molecular markers based on mitochondrial and nuclear DNA to highlight the importance of conservation genetics and the implications on a global scale to manage marine species in danger of extinction. (studiesabroad.com)
- During the first three semesters, the programme consists of modules primarily dedicated to the basics of biology such as botany, zoology, microbiology, genetics, and ecology as well as science including chemistry, mathematics, physics, or computer science, and a foreign language course. (tu-dresden.de)
- In my laboratory we use methods of molecular genetics and genomics to understand how trees grow, develop and interact with their environment. (mtu.edu)
- A Genetics and Molecular Biology é a nova revista publicada quadrimestralmente pela Sociedade Brasileira de Genética (Brazilian Genetics Society), em substituição ao Brazilian Journal of Genetics. (bvsalud.org)
Biochemistry and Molecular Biology1
- Critical Reviews in Biochemistry and Molecular Biology. (cdc.gov)
- Nature Reviews Molecular Cell Biology adalah jurnal tinjauan bulanan terdepan yang diterbitkan oleh Nature Publishing Group . (wikipedia.org)
- DNA molecule within each human cell is constantly exposed to an array of damaging agents from environmental sources and recent molecular studies have identified sophisticated mechanisms by which cells efficiently repair DNA breaks. (who.int)
- The present investigations were focused on understanding the cellular and molecular mechanisms induced by raw SWCNT (SWCNT) in human bronchial-epithelial cells (BEAS-2B). (cdc.gov)
- Positions are available for passionate students who wish to pursue intensive training and research in molecular and cellular neuroscience. (uoguelph.ca)
- At the end of my graduate studies, I received a CIHR Postdoctoral Fellowship to continue my training in molecular and cellular neuroscience in the laboratory of Dr. Grace Gill at Tufts University School of Medicine. (uoguelph.ca)
- During the summer of 2017, I became a faculty member of the College of Biological Science at the University of Guelph where I lead the Laboratory of Molecular and Cellular Neuroscience. (uoguelph.ca)
- The 2018 Gordon Research Conference on Cellular and Molecular Fungal Biology will focus on the incredible diversity of fungal form and lifestyle. (grc.org)
- This GRC will be held in conjunction with the "Cellular and Molecular Fungal Biology" Gordon Research Seminar (GRS). (grc.org)
- In the Farmer lab, we integrate multiple animal models (i.e. mice and zebrafish) with cutting edge genomic, genetic and imaging technologies to decipher the molecular and cellular basis of calvaria development. (ucla.edu)
- We use a range of techniques to understand the chemical and physical processes which drive molecular organization in lipids, polymers and proteins to rationally control self-assembly for the construction of novel proto-cellular platforms. (mpi-cbg.de)
- Report of an Informal Consultation on the Role of Molecular Biology and Genetic Engineering in the Development of Biocontrol of Disease Vectors, Geneva. (who.int)
- The CDC-authored Genomics and Precision Health Publications Database (GPHPD) has more than 3,600 publications, most of which are in pathogen genomics and advanced molecular detection. (cdc.gov)
- Chou, K.C. (2020) Proposing 5-Steps Rule Is a Notable Milestone for Studying Molecular Biology. (scirp.org)
- The Newborn Screening and Molecular Biology Branch (NSMBB) has the only laboratory in the world devoted to ensuring the accuracy of newborn screening tests in every state and more than 80 countries. (cdc.gov)
- NSQAP works with other programs in the NSMBB: the Biochemical Mass Spectrometry Laboratory, the Newborn Screening Translation Research Laboratory, and the Molecular Quality Improvement Program. (cdc.gov)
- This includes program-tailored guidance for laboratory-specific needs and help in evaluating ongoing and future molecular testing procedures. (cdc.gov)
- CDC's Newborn Screening and Molecular Biology Branch (NSMBB) has been granted ISO/IEC 17043 accreditation by the American Association for Laboratory Accreditation (A2LA) External external icon . (cdc.gov)
- Application to molecular biology research and Good Laboratory Practice (GLP). (uu.se)
- Jasmine has been conducting her doctoral dissertation research in the laboratory of Dr. Eishi Noguchi (Department of Biochemistry & Molecular Biology). (drexel.edu)
- At the molecular level, MWCNT exposure significantly increased the expression of the cell proliferation markers Ki-67 and PCNA and a panel of cell cycle-controlling genes in the lungs in a TIMP1- dependent manner. (cdc.gov)
- Course description The use of biological-molecular tools has revolutionized research in marine sciences in recent decades. (studiesabroad.com)
- Ammonium acetate solution can be used to study molecular biology, biological buffers, reagents and DNA and RNA purification. (sigmaaldrich.com)
- Considering the role of airway epithelium as a critical barrier for normal pulmonary function and focal point for tumor development, this study demonstrates that raw SWCNT activate molecular events which may be linked to adverse biological responses implicated in pulmonary diseases. (cdc.gov)
- There, I gained unique research experience in neuropharmacology, translational neuroscience, stem cell biology, mass spectrometry, and the development of assays adapted for image-based, high-throughput phenotypic screening with primary neuronal cells. (uoguelph.ca)
- Through his leadership, his team developed molecular assays to detect, differentiate and identify picornaviruses. (cdc.gov)
- IEEE/ACM Transactions on Computational Biology and Bioinformatics. (scirp.org)
- Working between biophysics, materials science and synthetic biology we reimagine and translate the physical phenemona which drive out of equilibrium processes in cells into novel, robust and dynamic systems for synthetic biology applications. (mpi-cbg.de)
- The present study aims to update the dentist clinician, approaching new concepts and techniques in molecular biology, in dentistry and in the prevention of dental caries. (bvsalud.org)
- The results of this study show that the molecular mechanism for raw SWCNT-mediated toxicity in BEAS-2B cells is through the activation of caspase-3, caspase-7, and PARP-1. (cdc.gov)
- While at MGH, I was also an affiliated member of the Stanley Center for Psychiatric Research at the Broad Institute of MIT and Harvard where I collaborated on projects investigating the molecular underpinnings of neuropsychiatric disorders, in particular, bipolar disorder and schizophrenia, with the help of patient-derived induced pluripotent stem cells (iPSCs). (uoguelph.ca)
- Accumulating evidence strongly suggests that perturbation of the molecular interactions responsible for the growth of neurons, or the capacity of these cells to adequately respond to activity-dependent signals, contributes to the pathophysiology of different brain disorders such as schizophrenia, intellectual disability, and autism spectrum disorders. (uoguelph.ca)
- Capacity to analyze the role of the use of molecular markers in marine sciences. (studiesabroad.com)
- Capacity to recognize the main tools used in molecular biology. (studiesabroad.com)
- After completing my B.A., I joined the Department of Psychology at McGill University where I did an M.A. in the area of visual psychophysics followed by a Ph.D. focusing on the molecular basis of activity-dependent visual cortex plasticity. (uoguelph.ca)
- Emily Esquea received the 2022 Award for Excellence in Research (MS degree) given by the Division of Biomedical Science Graduate Programs and the 2022 Jane Clifford Best MS Thesis Award given by the Department of Biochemistry & Molecular Biology. (drexel.edu)
- Michelle Swift received the 2022 Jane Clifford Best PhD Dissertation Award given by the Department of Biochemistry & Molecular Biology and the 2022 Amedio Bondi Endowed Graduate Award for Excellence in Research Performance, the highest recognition given to students at Graduate School of Biomedical Sciences and Professional Studies. (drexel.edu)
- Dr. Rosen had been chairperson of the Department of Molecular Pharmacology at Albert Einstein College of Medicine. (mskcc.org)
- Research Associate, Molecular and protein engineering. (assignmentexpert.com)
- The Molecular Quality Improvement Program oversees the cystic fibrosis DNA PT program and helps newborn screening laboratories with molecular testing. (cdc.gov)
- It also offers the molecular assessment program, which conducts site visits to U.S. newborn screening laboratories that carry out molecular testing. (cdc.gov)
- Ora Rosen, an expert in insulin signaling, co-founded the Molecular Biology Program at the Sloan Kettering Institute. (mskcc.org)
- One of those scientists was molecular biologist Ora Mendelsohn Rosen, who, along with Jerard Hurwitz , co-founded SKI's Molecular Biology Program. (mskcc.org)
- She played a role in the recruitment of Joan Massagué , currently SKI's Director, to chair the institute's newly formed Cell Biology Program in 1989. (mskcc.org)
- Biology is well equipped in exploiting a large number of out of equilibrium processes to support life. (mpi-cbg.de)
- How to apply molecular biology techniques in addressing problems regarding the conservation biology of endangered marine species in Costa Rica? (studiesabroad.com)
- We will explore environmental sensing, signaling, morphology and molecular motors, as well as the synthetic design and commercial exploitation of fungal systems. (grc.org)
- Dr. Rosen's area of expertise was the biology of insulin, the hormone that stimulates cells to take up glucose. (mskcc.org)
- However, which basic molecular building blocks they use to assemble target molecules is often unknown and difficult to measure. (news-medical.net)
- Fungal diversity presents rich opportunities to discover and characterize divergent mechanistic solutions to evolutionary pressures and environmental challenges, advancing our understanding of biology as a whole. (grc.org)
- For pharmaceuticals, knowing the chemical composition is not enough-;molecular geometry and crystal structure also play an important role in a drug's activity. (news-medical.net)
- The "5-steps rule" has played substantial roles in stimulating in-depth studies of molecular biology, both theoretical and experimental. (scirp.org)
- I consider myself extremely fortunate to live in a time when genome revolution in many areas of biology is enabling unprecedented depth into our understanding of life. (mtu.edu)
- He has over 21 years of experience in molecular biology and biochemistry of enteroviruses. (cdc.gov)
- The advances in the knowledge of molecular biology and the human genome provide evidence that the majority of the human diseases are influenced by alterations in genetic structures. (bvsalud.org)
- It is instructive to point out that in the systems of molecular biology there exist many multi-label ones where each of the individual constituents or samples considered may need two or more labels for distinction. (scirp.org)
- The molecular biology and therapeutic potential of Nrf2 in leukemia. (bvsalud.org)
- These visits assess all components of molecular testing. (cdc.gov)