Access to Information
Journal Impact Factor
Peer Review, Research
The evaluation by experts of the quality and pertinence of research or research proposals of other experts in the same field. Peer review is used by editors in deciding which submissions warrant publication, by granting agencies to determine which proposals should be funded, and by academic institutions in tenure decisions.
Blood Flow Velocity
A fat-soluble riminophenazine dye used for the treatment of leprosy. It has been used investigationally in combination with other antimycobacterial drugs to treat Mycobacterium avium infections in AIDS patients. Clofazimine also has a marked anti-inflammatory effect and is given to control the leprosy reaction, erythema nodosum leprosum. (From AMA Drug Evaluations Annual, 1993, p1619)
The transmission and reproduction of transient images of fixed or moving objects. An electronic system of transmitting such images together with sound over a wire or through space by apparatus that converts light and sound into electrical waves and reconverts them into visible light rays and audible sound. (From Webster, 3rd ed)
The process of generating three-dimensional images by electronic, photographic, or other methods. For example, three-dimensional images can be generated by assembling multiple tomographic images with the aid of a computer, while photographic 3-D images (HOLOGRAPHY) can be made by exposing film to the interference pattern created when two laser light sources shine on an object.
Predictive Value of Tests
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Cardiac Imaging Techniques
Extensive collections, reputedly complete, of facts and data garnered from material of a specialized subject area and made available for analysis and application. The collection can be automated by various contemporary methods for retrieval. The concept should be differentiated from DATABASES, BIBLIOGRAPHIC which is restricted to collections of bibliographic references.
Clinical Laboratory Information Systems
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
Ischemic Attack, Transient
Brief reversible episodes of focal, nonconvulsive ischemic dysfunction of the brain having a duration of less than 24 hours, and usually less than one hour, caused by transient thrombotic or embolic blood vessel occlusion or stenosis. Events may be classified by arterial distribution, temporal pattern, or etiology (e.g., embolic vs. thrombotic). (From Adams et al., Principles of Neurology, 6th ed, pp814-6)
Clinical Chemistry Tests
A method of comparing the cost of a program with its expected benefits in dollars (or other currency). The benefit-to-cost ratio is a measure of total return expected per unit of money spent. This analysis generally excludes consideration of factors that are not measured ultimately in economic terms. Cost effectiveness compares alternative ways to achieve a specific set of results.
Fractional Flow Reserve, Myocardial
Pulmonary Disease, Chronic Obstructive
National Heart, Lung, and Blood Institute (U.S.)
Component of the NATIONAL INSTITUTES OF HEALTH. It conducts and supports research program related to diseases of the heart, blood vessels, lung, and blood; blood resources; and SLEEP WAKE DISORDERS. From 1948 until October 10, 1969, it was known as the National Heart Institute. From June 25, 1976, it was the National Heart and Lung Institute. Since October 1997, the NHLBI has also had administrative responsibility for the NIH Woman's Health Initiative.
Angiogenesis: a new theory for endometriosis. (1/3898)Excessive endometrial angiogenesis is proposed as an important mechanism in the pathogenesis of endometriosis. Evidence is reviewed for the hypothesis that the endometrium of women with endometriosis has an increased capacity to proliferate, implant and grow in the peritoneal cavity. Data is summarized indicating that the endometrium of patients with endometriosis shows enhanced endothelial cell proliferation. Results are also reviewed indicating that the cell adhesion molecule integrin alphavbeta3 is expressed in more blood vessels in the endometrium of women with endometriosis when compared with normal women. Taken together, these results provide evidence for increased endometrial angiogenesis in women with endometriosis when compared with normal subjects. Endometriosis is one of the family of angiogenic diseases. Other angiogenic diseases include solid tumours, rheumatoid arthritis, psoriasis and diabetic retanopathy. Excessive endometrial angiogenesis suggests novel new medical treatments for endometriosis aimed at the inhibition of angiogenesis. (+info)
Dual allosteric modulation of pacemaker (f) channels by cAMP and voltage in rabbit SA node. (2/3898)1. A Monod-Whyman-Changeux (MWC) allosteric reaction model was used in the attempt to describe the dual activation of 'pacemaker' f-channel gating subunits by voltage hyperpolarization and cyclic nucleotides. Whole-channel kinetics were described by assuming that channels are composed of two identical subunits gated independently according to the Hodgkin-Huxley (HH) equations. 2. The simple assumption that cAMP binding favours open channels was found to readily explain induction of depolarizing voltage shifts of open probability with a sigmoidal dependence on agonist concentration. 3. Voltage shifts of open probability were measured against cAMP concentration in macropatches of sino-atrial (SA) node cells; model fitting of dose-response relations yielded dissociation constants of 0.0732 and 0.4192 microM for cAMP binding to open and closed channels, respectively. The allosteric model correctly predicted the modification of the pacemaker current (If) time constant curve induced by 10 microM cAMP (13.7 mV depolarizing shift). 4. cAMP shifted deactivation more than activation rate constant curves, according to sigmoidal dose-response relations (maximal shifts of +22.3 and +13.4 mV at 10 microM cAMP, respectively); this feature was fully accounted for by allosteric interactions, and indicated that cAMP acts primarily by 'locking' f-channels in the open configuration. 5. These results provide an interpretation of the dual voltage- and cyclic nucleotide- dependence of f-channel activation. (+info)
Nonlinear indicial response of complex nonstationary oscillations as pulmonary hypertension responding to step hypoxia. (3/3898)This paper is devoted to the quantization of the degree of nonlinearity of the relationship between two biological variables when one of the variables is a complex nonstationary oscillatory signal. An example of the situation is the indicial responses of pulmonary blood pressure (P) to step changes of oxygen tension (DeltapO2) in the breathing gas. For a step change of DeltapO2 beginning at time t1, the pulmonary blood pressure is a nonlinear function of time and DeltapO2, which can be written as P(t-t1 | DeltapO2). An effective method does not exist to examine the nonlinear function P(t-t1 | DeltapO2). A systematic approach is proposed here. The definitions of mean trends and oscillations about the means are the keys. With these keys a practical method of calculation is devised. We fit the mean trends of blood pressure with analytic functions of time, whose nonlinearity with respect to the oxygen level is clarified here. The associated oscillations about the mean can be transformed into Hilbert spectrum. An integration of the square of the Hilbert spectrum over frequency yields a measure of oscillatory energy, which is also a function of time, whose mean trends can be expressed by analytic functions. The degree of nonlinearity of the oscillatory energy with respect to the oxygen level also is clarified here. Theoretical extension of the experimental nonlinear indicial functions to arbitrary history of hypoxia is proposed. Application of the results to tissue remodeling and tissue engineering of blood vessels is discussed. (+info)
Regulation of energy consumption in cardiac muscle: analysis of isometric contractions. (4/3898)The well-known linear relationship between oxygen consumption and force-length area or the force-time integral is analyzed here for isometric contractions. The analysis, which is based on a biochemical model that couples calcium kinetics with cross-bridge cycling, indicates that the change in the number of force-generating cross bridges with the change in the sarcomere length depends on the force generated by the cross bridges. This positive-feedback phenomenon is consistent with our reported cooperativity mechanism, whereby the affinity of the troponin for calcium and, hence, cross-bridge recruitment depends on the number of force-generating cross bridges. Moreover, it is demonstrated that a model that does not include a feedback mechanism cannot describe the dependence of energy consumption on the loading conditions. The cooperativity mechanism, which has been shown to determine the force-length relationship and the related Frank-Starling law, is shown here to provide the basis for the regulation of energy consumption in the cardiac muscle. (+info)
System identification of closed-loop cardiovascular control mechanisms: diabetic autonomic neuropathy. (5/3898)We applied cardiovascular system identification (CSI) to characterize closed-loop cardiovascular regulation in patients with diabetic autonomic neuropathy (DAN). The CSI method quantitatively analyzes beat-to-beat fluctuations in noninvasively measured heart rate, arterial blood pressure (ABP), and instantaneous lung volume (ILV) to characterize four physiological coupling mechanisms, two of which are autonomically mediated (the heart rate baroreflex and the coupling of respiration, measured in terms of ILV, to heart rate) and two of which are mechanically mediated (the coupling of ventricular contraction to the generation of the ABP wavelet and the coupling of respiration to ABP). We studied 37 control and 60 diabetic subjects who were classified as having minimal, moderate, or severe DAN on the basis of standard autonomic tests. The autonomically mediated couplings progressively decreased with increasing severity of DAN, whereas the mechanically mediated couplings were essentially unchanged. CSI identified differences between the minimal DAN and control groups, which were indistinguishable based on the standard autonomic tests. CSI may provide a powerful tool for assessing DAN. (+info)
Experimental assessment of proximal stent-graft (InterVascular) fixation in human cadaveric infrarenal aortas. (6/3898)OBJECTIVES: This paper investigates the radial deformation load of an aortic endoluminal prosthesis and determines the longitudinal load required to cause migration in a human cadaveric aorta of the endoprosthesis. DESIGN AND METHODS: The endovascular prosthesis under investigation was a 24 mm diameter, nitinol, self-expanding aortoaortic device (InterVascular, Clearwater, Florida, U.S.A.). Initially, a motorised digital force gauge developed an incremental load which was applied to the ends of five stent-grafts, to a maximum of 10 mm (42%) compression. Secondly, using a simple bench model, each ends of four stent-grafts were deployed into 10 cadaveric experimental aneurysm necks and a longitudinal load applied to effect distraction. RESULTS: Increasing load produced increasing percentage deformation of the stent-grafts. The mean longitudinal distraction load for an aneurysm neck of 20 mm was 409 g (200-480 g), for 15 mm was 277 g (130-410 g) and for 10 mm was 218 g (130-340 g). The aneurysm diameter and aortic calcification had p values of 0.002 and 0.047, respectively, while the p value for aneurysm neck length was less than 0.00001. CONCLUSIONS: These results suggest that there is a theoretical advantage of oversizing an aortic prosthesis and that sufficient anchorage is achieved in an aortic neck of 10 mm to prevent migration when fully deployed. (+info)
Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure, II: model studies. (7/3898)Ca2+ transients measured in failing human ventricular myocytes exhibit reduced amplitude, slowed relaxation, and blunted frequency dependence. In the companion article (O'Rourke B, Kass DA, Tomaselli GF, Kaab S, Tunin R, Marban E. Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart, I: experimental studies. Circ Res. 1999;84:562-570), O'Rourke et al show that Ca2+ transients recorded in myocytes isolated from canine hearts subjected to the tachycardia pacing protocol exhibit similar responses. Analyses of protein levels in these failing hearts reveal that both SR Ca2+ ATPase and phospholamban are decreased on average by 28% and that Na+/Ca2+ exchanger (NCX) protein is increased on average by 104%. In this article, we present a model of the canine midmyocardial ventricular action potential and Ca2+ transient. The model is used to estimate the degree of functional upregulation and downregulation of NCX and SR Ca2+ ATPase in heart failure using data obtained from 2 different experimental protocols. Model estimates of average SR Ca2+ ATPase functional downregulation obtained using these experimental protocols are 49% and 62%. Model estimates of average NCX functional upregulation range are 38% and 75%. Simulation of voltage-clamp Ca2+ transients indicates that such changes are sufficient to account for the reduced amplitude, altered shape, and slowed relaxation of Ca2+ transients in the failing canine heart. Model analyses also suggest that altered expression of Ca2+ handling proteins plays a significant role in prolongation of action potential duration in failing canine myocytes. (+info)
Cardiac sodium channel Markov model with temperature dependence and recovery from inactivation. (8/3898)A Markov model of the cardiac sodium channel is presented. The model is similar to the CA1 hippocampal neuron sodium channel model developed by Kuo and Bean (1994. Neuron. 12:819-829) with the following modifications: 1) an additional open state is added; 2) open-inactivated transitions are made voltage-dependent; and 3) channel rate constants are exponential functions of enthalpy, entropy, and voltage and have explicit temperature dependence. Model parameters are determined using a simulated annealing algorithm to minimize the error between model responses and various experimental data sets. The model reproduces a wide range of experimental data including ionic currents, gating currents, tail currents, steady-state inactivation, recovery from inactivation, and open time distributions over a temperature range of 10 degrees C to 25 degrees C. The model also predicts measures of single channel activity such as first latency, probability of a null sweep, and probability of reopening. (+info)
Retinal vascular geometry predicts incident renal dysfunction in young people with type 1 diabetes<...
TY - JOUR. T1 - Retinal vascular geometry predicts incident renal dysfunction in young people with type 1 diabetes. AU - Benitez-Aguirre, P.Z.. AU - Craig, M.E.. AU - Cusumano, J.. AU - Jenkins, A.J.. AU - Donaghue, K.C.. AU - Sasongko, M.B.. AU - Cheung, N.. AU - Wong, T.Y.. PY - 2012/3/1. Y1 - 2012/3/1. N2 - OBJECTIVE - To examine the relationship between retinal vascular geometry parameters and development of incident renal dysfunction in young people with type 1 diabetes. RESEARCH DESIGN AND METHODS - This was a prospective cohort study of 511 adolescents with type 1 diabetes of at least 2 years duration, with normal albumin excretion rate (AER) and no retinopathy at baseline while attending an Australian tertiary-care hospital. AER was quantified using three overnight, timed urine specimen collections and early renal dysfunction was defined as AER ,7.5 µg/min. Retinal vascular geometry (including length-to-diameter ratio [LDR] and simple tortuosity [ST]) was quantified from baseline ...
A bilayer small diameter in vitro vascular model for evaluation of drug induced vascular injury. - Semantic Scholar
In pre-clinical safety studies, drug-induced vascular injury (DIVI) is defined as an adverse response to a drug characterized by degenerative and hyperplastic changes of endothelial cells and vascular smooth muscle cells. Inflammation may also be seen, along with extravasation of red blood cells into the smooth muscle layer (i.e., hemorrhage). Drugs that cause DIVI are often discontinued from development after considerable cost has occurred. An in vitro vascular model has been developed using endothelial and smooth muscle cells in co-culture across a porous membrane mimicking the internal elastic lamina. Arterial flow rates of perfusion media within the endothelial chamber of the model induce physiologic endothelial cell alignment. Pilot testing with a drug known to cause DIVI induced extravasation of red blood cells into the smooth muscle layer in all devices with no extravasation seen in control devices. This engineered vascular model offers the potential to evaluate candidate drugs for DIVI early in
The Adolescent Cardio-Renal Intervention Trial (AdDIT): retinal vascular geometry and renal function in adolescents with type 1...
Benitez-Aguirre PZ, Wong TY, Craig ME, Davis EA, Cotterill A, Couper JJ, Cameron FJ, Mahmud FH, Jones TW, Hodgson LAB, Dalton RN, Dunger DB, Donaghue KC, Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial (AdDIT). The Adolescent Cardio-Renal Intervention Trial (AdDIT): retinal vascular geometry and renal function in adolescents with type 1 diabetes. Diabetologia 61 (4) : 968 - 976(2018) PubMed (Grant IDs: 632521 ...
Prediction of the mechanical response of cardiac alternans by using an electromechanical model of human ventricular myocytes |...
Although the quantitative analysis of electromechanical alternans is important, previous studies have focused on electrical alternans, and there is a lack quantitative analysis of mechanical alternans at the subcellular level according to various basic cycle lengths (BCLs). Therefore, we used the excitation-contraction (E-C) coupling model of human ventricular cells to quantitatively analyze the mechanical alternans of ventricular cells according to various BCLs. To implement E-C coupling, we used calcium transient data, which is the output data of electrical simulation using the electrophysiological model of human ventricular myocytes, as the input data of mechanical simulation using the contractile myofilament dynamics model. Moreover, we applied various loads on ventricular cells for implementation of isotonic and isometric contraction. As the BCL was reduced from 1000 to 200 ms at 30 ms increments, mechanical alternans, as well as electrical alternans, were observed. At this time, the myocardial
Aorta zero-stress state modeling with T-spline discretization
The image-based arterial geometries used in patient-specific arterial fluid-structure interaction (FSI) computations, such as aorta FSI computations, do not come from the zero-stress state (ZSS) of the artery. We propose a method for estimating the ZSS required in the computations. Our estimate is based on T-spline discretization of the arterial wall and is in the form of integration-point-based ZSS (IPBZSS). The method has two main components. (1) An iterative method, which starts with a calculated initial guess, is used for computing the IPBZSS such that when a given pressure load is applied, the image-based target shape is matched. (2) A method, which is based on the shell model of the artery, is used for calculating the initial guess. The T-spline discretization enables dealing with complex arterial geometries, such as an aorta model with branches, while retaining the desirable features of isogeometric discretization. With higher-order basis functions of the isogeometric discretization, we ...
Národní úložiště šedé literatury
2017 - English 1 Abstract: Time-dependent and three-dimensional flow of Newtonian fluid is studied in context of two biomechanical applications, flow in cerebral aneurysms and flow in stenotic valves. In the first part of the thesis, the computational meshes obtained from the medical imaging techniques are used for the computation of hemodynamic parameters associated with the rupture potency of the cerebral aneurysms. The main result is the computation within twenty geometries of aneurysms. It is shown that the aneurysm size has more important role in wall shear stress distribution than the fact whether the aneurysm is ruptured or unruptured. The second part of the thesis is addressed to the flow in stenotic valves. It is shown that the method cur- rently used in medical practice is based on assumptions which are too restrictive to be apply to blood flow in the real case. The full continuum mechanics model is presented with physiologically relevant boundary conditions and it is shown that ...
Vascular model specialist- Trandomed
Buy and wholesale the high-tech and quality anatomy models, medical simulation, standard medical accessories for sale online with Trandomed which is one of the leading manufacturers and suppliers in China. Sample is available for quality checking and professional training is also available.
When Cardiac Biophysics Meets Data Science | Fields Institute for Research in Mathematical Sciences
Personalised cardiac models have attracted increasing interest from the clinical community over the past decade, however clinical validation is often restricted to few cases. This is due to the computational complexity of the models and of their personalisation, but also to the difficulty of acquiring the extensive datasets required for such personalised models. In this talk, I will present exemples of clinical applications where we leveraged on data science in order to increase the applicability and robustness of such personalised cardiac models. Machine learning methods have been developed in order to benefit from both the physiological constraints of the model and the efficiency of the learning.. ...
Why does algae keep coming back on walls?
Since switching to BBB method last summer I am having a recurrent problem with algae just on the pool walls. It poofs up when brushed and is bright green. I will go through the shock process despite water being clear and cc 0 with no overnight fC loss. The chlorine did not go below 8-10 last 2 weeks (I have SWG by the way) and I kept it there and I still saw algae reappearing on walls. We brush once a week (I have a bad back). Filter pressure good at 10. From opening until a couple of weeks ago
Stocks open higher on Wall Street as Big Tech regains ground | ArkLaTexHomepage
Stocks are opening higher on Wall Street following three days of losses and the biggest one-day drop in the S&P 500 since February. Big Tech companies like Apple and Microsoft, which had posted some of the bigger losses this week, were rising in the early going Thursday. the S&P 500 added 0.8% in the first […]
Why did infinite scroll fail at Etsy? - danwin.com
Assumption #2 was tested by artificially slowing down search for a cohort of users. These users did not necessarily react positively to slower results. But their engagement level was not statistically significantly lessened.). The point of McKinleys talk was that instead of having the goal of test infinite scroll, Etsy realized it needed to test each assumption separately, and this going forward is their game plan (the success case McKinley gives is the revamp of Etsys search box).. As I said, a great talk worth checking out. However, McKinley didnt have an answer for this:. Even if user engagement isnt positively influenced by more results per page or by faster results, why does the combination of both have a decidedly negative impact?. The decision to try infinite scroll was partially influenced by Google apparent success with instant search results, according to McKinley. And its a feature that is prominent among popular Tumblr themes, Pinterest, and of course, at Facebook and ...
Scroll Table Lamp | Kirklands
In a dark study sits the Scroll Table Lamp, softly glowing in the room. Create that feel in your space with the lamps scroll design and brown brush finish.
Idiot President Who Has No Border Policy Lectures Trump On Wall
DNA Force Plus is the most powerful Infowars Life formula yet! Try it today and see why so many listeners have made it an essential part of their daily routine ...
Simple Responsive Scroll Snap Point Demo
Demoing how to use scroll snap points to make a many page gallery or scrolling site. Im using a polyfill here for full support, but if you want to se...
Nevro posts Street-beating Q4 results - MassDevice
Nevro posted Q4 results that beat the consensus forecast on Wall Street as it issued 2021 guidance that was slightly below expectations.
Adding Multiple Panels and Single Scroll bar on the JFrame
I need to add multiple panels on the Jframe one after another(Vertically). To visualize the Problem let us take an example. In the website, there are
scroll | The Jewish Press - JewishPress.com
Printed from: http://www.jewishpress.com/news/breaking-news/ein-gedi-scroll-target-of-hi-tec-recovery-mission/2016/09/22/. Scan this QR code to visit this page online ...
Quark model study of the semileptonic B -| pi decay - ePrints Soton
The semileptonic decay B→π is studied starting from a simple quark model and taking into account the effect of the B* resonance. A novel, multiply subtracted, Omnès dispersion relation has been implemented to extend the predictions of the quark model to all physical q2 values. We find ,Vub, = 0.0034 ± 0.0003(exp.) ± 0.0007(theory), in good agreement with experiment.. Full text not available from this repository.. ...
Blender.org - Search
If you dont have the time for it, I would be happy to take a look at that on an evening this week, should take me no more than 15 minutes so its no problem at all. I would be really thankful - I just dont want to scroll a page for 15 minutes just because some people think the best way of doing l ...
Paste in page view jumps to top of page | MuseScore
Create a score with enough staves that you can scroll the top staff off the top of the screen in page view. Copy notes from somewhere, possibly another score…
Retinal Vascular Geometry Predicts Incident Renal Dysfunction in Young People With Type 1 Diabetes | Diabetes Care
RESEARCH DESIGN AND METHODS A prospective cohort study of 511 adolescents with type 1 diabetes of at least 2 years duration, with normal albumin excretion rate (AER) and no retinopathy at baseline while attending an Australian tertiary-care hospital. AER was quantified using three overnight, timed urine specimen collections and early renal dysfunction was defined as AER ,7.5 μg/min. Retinal vascular geometry (including length-to-diameter ratio [LDR] and simple tortuosity [ST]) was quantified from baseline retinal photographs. Generalized estimating equations were used to examine the relationship between incident renal dysfunction and baseline venular LDR and ST, adjusting for age, diabetes duration, glycated hemoglobin (A1C), blood pressure (BP), BMI, and cholesterol. ...
SOLIDWORKS Flow Simulation | Đại Lý Ủy Quyền SOLIDWORKS |PCB GraphTech
The calculation of temperature change in the products solid geometry is an option selection. Conjugate heat transfer through convection, conduction, and radiation can be created. Calculations can include thermal contact resistance.. SOLIDWORKS Flow Simulation: Calculate pure heat conduction in solids to identify problems where no fluid exists for fast solutions.. SOLIDWORKS Flow Simulation and HVAC Module: Include materials that are semitransparent to radiation, for accurate solutions where the products thermal load is influenced by transparent materials.. SOLIDWORKS Flow Simulation and Electrical Cooling Module: Simulate specific electronics device effects. ...
State observers of a vascular fluid-structure interaction model through measurements in the solid
We analyze the performances of two types of Luenberger observers -- namely, the so-called Direct Velocity Feedback and Schur Displacement Feedback procedures, originally devised for elasto-dynamics -- to estimate the state of a fluid-structure interaction model for hemodynamics, when the measurements are assumed to be restricted to displacements or velocities in the solid. We first assess the observers using hemodynamics-inspired test problems with the complete model, including the Navier-Stokes equations in Arbitrary Lagrangian-Eulerian formulation, in particular. Then, in order to obtain more detailed insight we consider several well-chosen simplified models, each of which allowing a thorough analysis -- emphasizing spectral considerations -- while illustrating a major phenomenon of interest for the observer performance, namely, the added mass effect for the structure, the coupling with a lumped-parameter boundary condition model for the fluid flow, and the fluid dynamics effect per se. Whereas
Alterations in regional vascular geometry produced by theoretical stent implantation influence distributions of wall shear...
The success of stent implantation in the restoration of blood flow through areas of vascular narrowing is limited by restenosis. Several recent studies have suggested that the local geometric environment created by a deployed stent may influence regional blood flow characteristics and alter distributions of wall shear stress (WSS) after implantation, thereby rendering specific areas of the vessel wall more susceptible to neointimal hyperplasia and restenosis. Stents are most frequently implanted in curved vessels such as the coronary arteries, but most computational studies examining blood flow patterns through stented vessels conducted to date use linear, cylindrical geometric models. It appears highly probable that restenosis occurring after stent implantation in curved arteries also occurs as a consequence of changes in fluid dynamics that are established immediately after stent implantation. In the current investigation, we tested the hypothesis that acute changes in stent-induced regional geometry
Similar papers for Spiral Wave Dynamics in Neocortex - Semantic Scholar
Although spiral waves are ubiquitous features of nature and have been observed in many biological systems, their existence and potential function in mammalian cerebral cortex remain uncertain. Using voltage-sensitive dye imaging, we found that spiral waves occur frequently in the neocortex in vivo, both during pharmacologically induced oscillations and during sleep-like states. While their life span is limited, spiral waves can modify ongoing cortical activity by influencing oscillation frequencies and spatial coherence and by reducing amplitude in the area surrounding the spiral phase singularity. During sleep-like states, the rate of occurrence of spiral waves varies greatly depending on brain states. These results support the hypothesis that spiral waves, as an emergent activity pattern, can organize and modulate cortical population activity on the mesoscopic scale and may contribute to both normal cortical processing and to pathological patterns of activity such as those found in epilepsy.
Fluid-Structure Interactions in Low-Reynolds-Number Flows » GFXHome | Best CG / VFX Resources for Artists!
Fluid-Structure Interactions in Low-Reynolds-Number Flows (RSC Soft Matter Series, Book 4) by Camille Duprat and Howard A Stone English | 2015 | ISBN: 1849738130 | 483 pages | PDF | 160 MB
Uncertainty Quantification and Sensitivity Analysis for Cardiovascular Models | Simula Research Laboratory
The major challenge for applying cardiovascular models in personalized medicine is as follows: How certain are the predictions of a cardiovascular model, taking the natural variations and measurement uncertainty of model inputs into account?. To address this challenge, we combined methodologies for uncertainty quantification (UQ) and sensitivity analysis (SA) with cardiovascular models. In a comprehensive guide to UQ and SA, we showed how to quantify the uncertainties of model predictions and the sensitivity of model predictions with respect to model inputs. The approach is exemplified for two clinically relevant models, predicting the following: i.) the severity of coronary artery stenosis, which is a predisposition to stroke and transient ischaemic attack, and ii.) the total arterial compliance, which is considered to be a cardiovascular risk factor, indicating the development of hypertension and atherosclerosis. Furthermore, we developed a framework for UQ and SA in a one-dimensional blood ...
Remodeling of blood vessels: Responses of diameter and wall thickness to hemodynamic and metabolic stimuli<...
TY - JOUR. T1 - Remodeling of blood vessels. T2 - Responses of diameter and wall thickness to hemodynamic and metabolic stimuli. AU - Pries, Axel R.. AU - Reglin, Bettina. AU - Secomb, Timothy W.. PY - 2005/10. Y1 - 2005/10. N2 - Vascular functions, including tissue perfusion and peripheral resistance, reflect continuous structural adaptation (remodeling) of blood vessels in response to several stimuli. Here, a theoretical model is presented that relates the structural and functional properties of microvascular networks to the adaptive responses of individual segments to hemodynamic and metabolic stimuli. All vessels are assumed to respond, according to a common set of adaptation rules, to changes in wall shear stress, circumferential wall stress, and tissue metabolic status (indicated by partial pressure of oxygen). An increase in vessel diameter with increasing wall shear stress and an increase in wall mass with increased circumferential stress are needed to ensure stable vascular adaptation. ...
Simulation of blood flow and vessel deformation in three-dimensional, patient-specific models of the cardiovascular system...
Simulation of blood flow and vessel deformation in three-dimensional, patient-specific models of the cardiovascular system using a novel method for fluid-solid interactions Conference Proceeding ...
At Scroll Suppliers, all Quality At Scroll Suppliers on Alibaba.com
At Scroll, At Scroll Suppliers Directory - Find variety At Scroll Suppliers, Manufacturers, Companies from around the World at scroll wedding invitations ,scroll bending machine ,atlas copco scroll compressor, Artificial Crafts
Differences in Aortic Arch Geometry, Hemodynamics, and Plaque Patterns Between C57BL/6 and 129/SvEv Mice | Journal of...
Atherosclerotic plaques are distributed differently in the aortic arches of C57BL/6 (B6) and 129/SvEv (129) apolipoprotein E (apoE)-deficient mice. It is now recognized that hemodynamic wall shear stress (WSS) plays an important role in the localization of atherosclerotic development. Since the blood flow field in the vessel is modulated by the vascular geometry, we quantitatively examined the difference in the aortic arch geometry and hemodynamic WSS between the two corresponding wild-type mouse strains. The three-dimensional (3D) geometry of 14 murine aortic arches, seven from each strain, was characterized using casts and stereo microscopic imaging. Based on the geometry of each cast, an average 3D geometry of the aortic arch for each mouse strain was obtained, and computational fluid dynamic calculations were performed in the two average aortic arches. Many geometric features, including aortic arch shape, vessel diameter, and branch locations, were significantly different at ...
Patent USD285112 - Physiological pressure monitoring instrument - Google Patents
FIG. 1 is a front perspective view of physiological pressure monitoring instrument embodying our design;. FIG. 2 is a front elevational view thereof;. FIG. 3 is a left side elevational view thereof;. FIG. 4 is a right side elevational view thereof;. FIG. 5 is a back elevational view of the instrument case, showing the side opposite that shown in FIG. 1;. FIG. 6 is a top plan view thereof.. FIG. 7 is a bottom plan view thereof.. ...
Relationship Between the Dynamic Geometry and Wall Thickness of a Human Coronary Artery | Arteriosclerosis, Thrombosis, and...
The results in this study indicate significant relationships between dynamic geometry and vessel wall thickness. The R2 values of the univariate regressions indicate that no single geometric factor has a dominant role in determining vessel wall thickness. On the other hand, the probability values of the multivariate regressions are all highly significant, and the correlation coefficients are substantially higher as well. Thus, thickening seems to be influenced by multiple aspects of the dynamic vascular geometry. This is to be expected; the geometric factors are postulated to act through their influence on the fluid dynamic and mechanical stresses experienced by the wall, and it is reasonable that each of these stresses would be influenced by multiple dynamic and geometric parameters. It is noteworthy in this respect that the signs of the regression coefficients in the univariate and multivariate regressions in Tables 2 and 3⇑ are consistent.. According to the signs of the regression ...
ModelDB: Human seizures couple across spatial scales through travelling wave dynamics (Martinet et al 2017)
We show that during seizure large-scale neural populations spanning centimetres of cortex coordinate with small neural groups spanning cortical columns, and provide evidence that rapidly propagating waves of activity underlie this increased inter-scale coupling. We develop a corresponding computational model to propose specific mechanisms-namely, the effects of an increased extracellular potassium concentration diffusing in space-that support the observed spatiotemporal dynamics. Understanding the multi-scale, spatiotemporal dynamics of human seizures-and connecting these dynamics to specific biological mechanisms-promises new insights to treat this devastating disease ...
Advances in Computational Fluid-Structure Interaction and Flow | Yuri Bazilevs | Springer
A tribute to the life and work of Tayfun E. Tezduyar on the occasion of his 60th Birthday Chapters discuss recent trends and new directions in
SOLIDWORKS 2015 Whats New - Flow Simulation Rotating Mesh #SW2015 - Computer Aided Technology
Rotating Regions can be used in analysis of fluid flow where components are rotating over different axes and/or at different speeds or if the computational domain is non-axisymmetric with respect to rotating component. Each rotating region is surronded by axisymmetric rotating region which has its own coordinate system rotating together with the component. Influence of rotation is taken into account in each of the rotating coordinate systems. To connect solutions within rotating regions and in the non-rotating part of computational domain, special internal boundary conditions are set automatically at fluid boundaries of the rotating regions. The values of flow parameters transferred as boundary conditions from adjacent fluid regions are averaged circumferentially over each rotating region. Image below shows how the averaging across the boundary affects the solution. ...
What Are the Causes of Thermal Tracking on Walls? | eHow
Thermal tracking on walls appears as dark soot stains. The air in the house must be full of moisture and warmer than the wall to produce the stains. Once the warm, damp air touches a cooler spot on the wall, some of the airs moisture coats the walls surface with condensation.
paizo.com - Forums: Rules Questions: This is a Scroll of X
Deciphering a scroll isnt figuring out what it is. Its figuring our what all the damn squiggles are. As a real-world example, consider the simple ampersand (&). Do you have any idea how many different ways scribes have drawn a symbol that means and? Theres a surprising amount of variation, and if youre not prepared for it, this can make it hard to read. Medieval scribes were often called upon to make long documents, and the list of random squiggles they used to simplify their job was immense. Even names got abbreviated, and you were just supposed to know that Dy meant Dorothy, not Dylan or Dyvas. Good Lord, we do that today in text messaging and text channels.. As per rules, if the person who wrote the scroll is there, you can ask him What the hell does qq. mean? Just knowing that this is a scroll of fireball doesnt tell you how to activate the scroll. To actually activate it, you need to pronounce qq. correctly.. ...
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Department of Computer Science, University of Oxford: Publication - Comparison of Rule−Based and DTMRI−Derived Fibre...
The anisotropic electrical conduction within myocardial tissue due to preferential cardiac myocyte orientation (fibre orientation) is known to impact strongly in electrical wavefront dynamics, particularly during arrhythmogenesis. Faithful representation of cardiac fibre architecture within computational cardiac models which seek to investigate such phenomena is thus imperative. Drawbacks in derivation of fibre structure from imaging modalities often render rule-based representations based on a priori knowledge pr
Hopp til første side 3D Flow Simulation By Sigve Hovda, Ph.D student Three Dimentional Computational Fluid Dynamic Model of the...
Hopp til første side Spline Representation n Spline representation of the first and last volume n Interpolation in time between these volumes n Animation of the mesh
SOLIDWORKS Plastics: Reject Risk in Mold Injection | Videos | SOLIDWORKS
Learn how SOLIDWORKS Flow Simulation enables you to quickly and easily simulate liquid and gas flows through and around your designs to calculate product performance and capabilities.. Go Further: Explore the Benefits of SOLIDWORKS Flow Simulation and Concurrent Engineering. Learn more about SOLIDWORKS Plastics by visiting solidworks.com/flow. ...
how to add scroll bar to #content? [Archive] - CodingForums
Dear all, My webpage is divided into - #header - #nav (which is a toolbar on the left) - #content - #footer How can I add a scroll bar to my #content (so that only my content scrolls up and down, with my navigation, header and footer all remaining not moving). This is an example (although I prefer to have a different scroll bar): http://www.zhangxiaogang.org/Enworks.aspx?type=year
Electrical turbulence in three-dimensional heart muscle | Science
Rotors or vortex action potentials with a diameter of about 1 centimeter and a rotation period of about 0.1 second occur in normal myocardium just before transition to fibrillation, a disorderly pattern of action potential propagation. Numerical models and corresponding mathematical analysis have recently suggested candidate mechanisms, all two-dimensional, for this transition from periodic electrical activity to something resembling turbulence. However, comparably recent experiments unanimously show that rotors, and the spiral waves they radiate, remain stably periodic in two-dimensional myocardium. This seeming paradox suggests a transition mediated through disorderly dynamics of the electrical vortex in three dimensions, as a vortex filament. ...
DERs Restoration Potential Model Tool | Mass.gov
DERs Restoration Potential Model (RPM) Tool displays information that can be used to evaluate the relative ecological benefit of removing any known dam in the Commonwealth.
Fluid Structure Interaction II | SpringerLink
Fluid-structure interactions (FSI), i.e., the interplay of some moveable or deformable structure with an internal or surrounding fluid, are among the most widespread and most challenging coupled or mu
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Scroll Text Software Downloads, Reviews: DS Blinds, DS Blobs, BookReader and More Scroll Text Programs
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Effect of Fiber Geometry on Pulsatile Pumping and Energy Expenditure | SpringerLink
Myocardial fiber orientation is a topic that has recently received much attention in connection with cardiac pumping function. The twisting motion of the cardiac base to apex can be a direct result of
Walking On Walls
this is the best way to learn back flips well its one way of learning them. have a nice soft mat and a wall and just keep running.
Overnight on Wall Street: Wednesday 13 May 2020
Global stocks rallied in the European and US session on Monday and experienced their best days in weeks. The markets also took note of the Feds comments that the US economy is expected to recover steadily towards the second half of the year but the recovery could drag through 2021.
Subsurface, Pore-Scale, and Forcheimer Flow Models
Discover how to analyze geophysical phenomena using the Subsurface Flow Module by downloading our subsurface flow tutorial models.
virtualbox.org • View topic - Problems With Mouse Scroll Wheel When Using Guest Additions
Here is some backgroud -- skip to the next paragraph for the meat of the problem. I have been fighting an issue with the mouse scroll wheel in (KDE based) Linux guests for quite some time now. It seemed to surface for me with the Fedora 22 release (possibly due to the KDE version included there). This issue does not occur in prior versions of the OS (such as Fedora 21), but does occur consistently in every version since (up through the current, Fedora 24). I had written this off to be solely an OS or desktop (KDE) issue, which is why I had not brought it here for help yet. However, I did some additional testing recently which has convinced me that this at least partially lies on the VirtualBox side. I took some time recently to to install a VirtualBox guest OpenSUSE KDE system and it encountered the exact same symptoms as the Fedora system. Then I took the (extensive) time to setup and configure an ArchLinux KDE system, and it too experienced the same symptoms. The final test that led me to post ...
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Elder Scrolls IV: Oblivion (Xbox 360) Reviews - alaTest.com
Read 5 reviews and find the lowest price for the Elder Scrolls IV: Oblivion (Xbox 360). Overall, this Xbox 360 Game is rated 78/100 Good.
Cardiotherapeutical Results From The Coupled Biomed And Guyton Models
The GUYTON model is still the most comprehensive cardiovascular model with a solid physiological background. However, it does not account for short...
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Is AbbVie Inc (ABBV) Wasting Your Money? - Insider Monkey
Stock buybacks are generally considered a bullish signal on Wall Street. They return capital to shareholders, while declaring managements belief that...
From Lehmans Wreckage, New Lives - WSJ
Richard Fuld is having a hard time putting the past behind him. As former Lehman employees have moved on, their former boss meets a rare degree of skepticism as he seeks to rebuild his presence on Wall Street.
Pagination: Infinite Scroll (First load via click) - Viral kahani| Best Viral Stories around the world
This demo site is only for demonstration purposes. All images are copyrighted to their respective owners. All content cited is derived from their respective sources.. ...
OFFICIAL - Elder Scrolls V : Skyrim (Discussion) | Page 232 | TechPowerUp Forums
Oh neat, hadnt heard of that. And dam 8GB?? I barely scratch 2GB. I jut cant find other textures mods worth adding myself. I thought Skyrim 2K HD would...
Where do I save Windows 7 themes?
You can see how to activated downloaded Windows 7 themes in recent MakeUseOf article, Top 5 Windows 7 Themes You Might Want To Try. Scroll towards the end of the article.. ...
GtkViewport: GTK+ 2 Reference Manual
The GtkViewport widget acts as an adaptor class, implementing scrollability for child widgets that lack their own scrolling capabilities. Use GtkViewport to scroll child widgets such as GtkTable, GtkBox, and so on.. If a widget has native scrolling abilities, such as GtkTextView, GtkTreeView or GtkIconview, it can be added to a GtkScrolledWindow with ...
Scroll: Jean-Claude Claeys, Christine Clavel, Ladronn, Nathalie Lial, Stephan Martiniere, Jean-Pierre Normand. Anne-Claire Payet, Jean-Michel Ponzio, Adam Tredowski, Yoz ...
Gross DR (2009). Animal models in cardiovascular research (3rd ed.). Dordrecht: Springer. p. 5. ISBN 9780387959627. . OCLC ... Haemodynamic and model analysis". Journal of Vascular Research. 29 (4): 293-312. doi:10.1159/000158945. ISSN 1018-1172. PMID ... The risk of cardiovascular disease increases progressively above 115/75 mmHg, below this level there is limited evidence. ... H.), Schmidt, T. F. H. (Thomas F. (1992). Temporal Variations of the Cardiovascular System. Engel, Bernard T., Blümchen, ...
Dupuy DE, Aswad B, Ng T (April 2011). "Irreversible electroporation in a Swine lung model". Cardiovascular and Interventional ... preliminary results in a porcine model". Cardiovascular and Interventional Radiology. 34 (6): 1278-87. doi:10.1007/s00270-011- ... IRE has also been investigated in ex-vivo human eye models for treatment of uveal melanoma and in thyroid cancer. Successful ... Cardiovascular and Interventional Radiology. 41 (3): 466-476. doi:10.1007/s00270-017-1795-x. PMID 28929209. S2CID 5024881. ...
Myosin binding protein C, cardiac
Jung G, Bernstein D (Jul 2014). "hiPSC Modeling of Inherited Cardiomyopathies". Current Treatment Options in Cardiovascular ... naturally-occurring or transgenic animal models and more recently disease modeling using induced pluripotent stem cells (iPSC)- ... Duncker DJ, Bakkers J, Brundel BJ, Robbins J, Tardiff JC, Carrier L (Apr 2015). "Animal and in silico models for the study of ... Duncker DJ, Bakkers J, Brundel BJ, Robbins J, Tardiff JC, Carrier L (Apr 2015). "Animal and in silico models for the study of ...
Spontaneously hypertensive rat
... used to study cardiovascular disease. It is the most studied model of hypertension measured as number of publications. The SHR ... "Lessons from rat models of hypertension: from Goldblatt to genetic engineering". Cardiovascular Research. 39 (1): 77-88. doi: ... The Spontaneous Hypertensive Rat is also a model for anxiety. Animal models of ischemic stroke Pinto YM, Paul ... If the animal is to be used as a model of ADHD, it is generally advised to start testing when the animals are around four weeks ...
Gross DR (2009). Animal Models in Cardiovascular Research (3rd ed.). Dordrecht: Springer. p. 5. ISBN 9780387959627. OCLC ... The risk of cardiovascular disease increases progressively above 115/75 mmHg, below this level there is limited evidence. ... Loss of the normal fall in blood pressure at night is associated with a greater future risk of cardiovascular disease and there ... Haemodynamic and model analysis". Journal of Vascular Research. 29 (4): 293-312. doi:10.1159/000158945. ISSN 1018-1172. PMID ...
"Human-induced pluripotent stem cells in modeling inherited cardiomyopathies". Journal of the Practice of Cardiovascular ... He is a member of the executive council of the Proteomic Society, India and is known for his studies of cardiovascular diseases ... Journal of the Practice of Cardiovascular Sciences. 2 (3): 151. doi:10.4103/jpcs.jpcs_62_16. Sengupta, Shantanu; Ghose, ... Journal of the Practice of Cardiovascular Sciences. 1 (1): 45. doi:10.4103/2395-5414.157568. Mendelian randomization ...
"Diastolic dysfunction in familial hypertrophic cardiomyopathy transgenic model mice". Cardiovascular Research. 82 (1): 84-92. ... In agreement with these findings, a second in vivo model, cardiac myosin light chain kinase (MYLK3) knockout (cMLCK neo/neo), ... The role of Myl2 mutations in pathogenesis has been determined through the generation of a number of mouse models. Transgenic ... In a novel MLC2v Ser14Ala/Ser15Ala knockin mouse model, complete loss of MLC2v (Ser14/Ser15) phosphorylation led to a worsened ...
Human Engineered Cardiac Tissues (hECTs)
Tulloch NL, Murry CE (Nov 2013). "Trends in cardiovascular engineering: organizing the human heart". Trends in Cardiovascular ... important advances have led to the generation of hECT patches for myocardial repair in animal models and use in in vitro models ... In animal models of myocardial infarction (MI), hECT injection into the hearts of rats and mice reduces infarct size and ... These tissues provide a unique in vitro model to study cardiac physiology with a species-specific advantage over cultured ...
WHO Model List of Essential Medicines
Cardiovascular medicines. Antianginal medicines. *Bisoprolol[note 68]. *Glyceryl trinitrate. *Isosorbide dinitrate ... Twentieth report of the WHO Expert Committee 2015 (including 19th WHO Model List of Essential Medicines and 5th WHO Model List ... including the 21st WHO Model List of Essential Medicines and the 7th WHO Model List of Essential Medicines for Children). ... including the 20th WHO Model List of Essential Medicines and the 6th Model List of Essential Medicines for Children). Geneva. ...
Deaths in February 2020
June Dally-Watkins, 92, Australian model and businesswoman. Kiki Dimoula, 88, Greek poet. Binoy Dutta, 75, Indian politician, ... Wichie Torres, 67, Puerto Rican painter, cardiovascular disease. Grazia Volpi, 78, Italian film producer (Caesar Must Die, ... Model, author, restaurateur B. Smith dies of early onset Alzheimer's disease at 70 HT Thích Quảng Độ 'hiến dâng cả đời đấu ... South Korean actress and model. Harold Strachan, 94, South African writer and anti-apartheid activist. Ann E. Todd, 88, ...
Models and Methods in Computational Vascular and Cardiovascular Mechanics. 198 (45): 3613-3621. Bibcode:2009CMAME.198.3613T. ... FSI models contain an overall lower WSS compared to non-compliant models. This is significant because incorrect modeling of ... Non-compliant models have a computational time of a few hours, while FSI models could take up to 7 days to finish running. This ... The interface quasi-Newton method with approximation for the inverse of the Jacobian from a least-squares model couples a black ...
"Pathological Effects of Pulmonary Vein beta-Radiation in a Swine Model". Journal of Cardiovascular Electrophysiology. 17 (6): ...
Occupational health psychology
An alternative model, the job demands-resources (JD-R) model, grew out of the DCS model. In the JD-R model, the category of ... Belkic, K.L., Landsbergis, P.A., Schnall, P.L., & Baker, D. (2004). Is job strain a source of major cardiovascular risk? ... After the DCS model, the second most influential model in OHP research has been the effort-reward imbalance (ERI) model. It ... The most influential model in OHP research has been the original demand-control model. According to the model, the combination ...
Hasenfuss G (1998). "Animal models of human cardiovascular disease, heart failure and hypertrophy". Cardiovasc. Res. 39 (1): 60 ... Sheep are generally too large and reproduce too slowly to make ideal research subjects, and thus are not a common model ... Pregnant sheep are also a useful model for human pregnancy, and have been used to investigate the effects on fetal development ... Barry JS; Anthony RV (2008). "The pregnant sheep as a model for human pregnancy". Theriogenology. 69 (1): 55-67. doi:10.1016/j. ...
Abdominal aortic aneurysm
These rubber models can also be used in a variety of experimental situations, from stress analysis using the photoelastic ... Hirose Y, Takamiya M (February 1998). "Growth curve of ruptured aortic aneurysm". The Journal of Cardiovascular Surgery. 39 (1 ... Numerical modeling is a valuable tool to researchers allowing approximate wall stresses to be calculated, thus revealing the ... Experimental models are required to validate these numerical results and provide a further insight into the biomechanical ...
Cardiovascular system. Women suffer less from heart disease due to vasculo-protective action of estrogen which helps in ... Baum MJ (November 2006). "Mammalian animal models of psychosexual differentiation: when is 'translation' to the human situation ... in a study using an estrogen-dependent breast cancer cell line as model, 89 such genes were identified). Since estrogen ... the utility of rodent models for studying human psychosexual differentiation has been questioned. ...
Rat Genome Database
... about disease models that gives detailed information about which rat strains have been used as models for human cardiovascular ... RGD's Phenotypes and Models portal focuses on strains, phenotypes and the rat as a model organism for physiology and disease. ... The Phenotypes and Models portal has five sections: "Phenotypes", "Strains & Models", "Meet Joe Rat", "PhenoMiner" and "Strain ... "2015 Guidelines for Establishing Genetically Modified Rat Models for Cardiovascular Research". J Cardiovasc Transl Res. 8 (4): ...
"WHO Model List of Essential Medicines" (PDF). World Health Organization. October 2013. Retrieved 24 September 2015. Noori S, ... While some effects result from stimulation of dopamine receptors, the prominent cardiovascular effects result from dopamine ... A neuropsychological model which distinguishes these two components of an intrinsically rewarding stimulus is the incentive ... In the model organism, nematode Caenorhabditis elegans, it reduces locomotion and increases food-exploratory movements; in ...
"Sodium current deficit and arrhythmogenesis in a murine model of plakophilin-2 haploinsufficiency". Cardiovascular Research. 95 ... These studies were further supported by an investigation in a mouse model harboring a PKP2-heterozygous null mutation, which ... Cardiovascular Research. 100 (2): 231-40. doi:10.1093/cvr/cvt191. PMC 3797628. PMID 23929525. Bonné S, van Hengel J, van Roy F ... Trends in Cardiovascular Medicine. 24 (5): 184-90. doi:10.1016/j.tcm.2014.02.001. PMC 4099253. PMID 24656989. Rickelt S, Rizzo ...
Peart JN, Gross ER, Gross GJ (March 2004). "Effect of exogenous kappa-opioid receptor activation in rat model of myocardial ... infarction". Journal of Cardiovascular Pharmacology. 43 (3): 410-5. doi:10.1097/00005344-200403000-00012. PMID 15076225. S2CID ...
McNeill E, Channon KM, Greaves DR (March 2010). "Inflammatory cell recruitment in cardiovascular disease: murine models and ... A subtype is implicated in Alzheimer's disease and cardiovascular disease. APOE belongs to a family of fat-binding proteins ... Cardiovascular & Haematological Disorders. 1 (2): 93-106. doi:10.2174/1568006013337944. PMID 12769659. Mahley RW, Rall SC (2002 ... APOE was initially recognized for its importance in lipoprotein metabolism and cardiovascular disease. Defects in APOE result ...
Insulin-like growth factor 1
IGF-1 may have a beneficial effect on atherosclerosis and cardiovascular disease. IGF-1 has also been shown to have an ... antidepressant effect in mouse models. Several companies have evaluated administering recombinant IGF-1 in clinical trials for ... Higashi Y, Gautam S, Delafontaine P, Sukhanov S (April 2019). "IGF-1 and cardiovascular disease". Growth Hormone & IGF Research ...
P. Jin; E. Haneda; K. D. Sauer; C. A. Bouman (June 2012). "A model-based 3D multi-slice helical CT reconstruction algorithm for ... Cardiovascular Imaging. 9 (11): 1349-1352. doi:10.1016/j.jcmg.2016.01.017. PMC 5106323. PMID 27209112. Archived from the ... ISBN 978-3-319-53496-1. Van de Casteele E, Van Dyck D, Sijbers J, Raman E (2004). "A model-based correction method for beam ... The epitomes of volume rendering models feature a mix of for example coloring and shading in order to create realistic and ...
Cardiovascular Imaging. 10 (2): 171-184. doi:10.1016/j.jcmg.2016.12.001. ISSN 1876-7591. PMC 5664227. PMID 28183437.. ... Leif Kobbelt (2006). Vision, Modeling, and Visualization 2006: Proceedings, November 22-24. IOS Press. ISBN 9783898380812.. ... Cardiovascular Imaging. 9 (11): 1349-1352. doi:10.1016/j.jcmg.2016.01.017. ISSN 1876-7591. PMC 5106323. PMID 27209112.. ... Still, the epitomes of volume rendering models feature a mix of for example coloring and shading in order to create ...
Dieta paleolítica - Viquipèdia, l'enciclopèdia lliure
Ungar, Peter S.; Grine, Frederick E.; & Teaford, Mark F. «Diet in Early Homo: A Review of the Evidence and a New Model of ... Expert Review of Cardiovascular Therapy, 5, 4, juliol 2007, pàg. 681-691. DOI: 10.1586/14779072.5.4.681. PMID: 17605647. ... di Costanzo, Jacques «Paleolithic nutrition: a model for the future?». Current Opinion in Clinical Nutrition & Metabolic Care, ...
Artificial heart valve
Tissue engineered heart valves can be person-specific and 3D modeled to fit an individual recipient 3D printing is used because ... "Surgical Valves , Trifecta GT Valve and Epic Mitral Valve". www.cardiovascular.abbott. Retrieved 2019-07-29. "LivaNova". www. ... Francis model) Artificial heart Mitral valve replacement Aortic valve replacement Kostrzewa B, Rybak Z (2013). "[History, ... "A randomized assessment of an advanced tissue preservation technology in the juvenile sheep model". The Journal of Thoracic and ...
Mitral valve replacement
They come in various sizes (commonly starting from an external diameter of 19 mm and increasing by 2 mm per model). Mechanical ... van der Merwe, J (2017). "Mitral Valve Replacement-Current and Future Perspectives". Open Journal of Cardiovascular Surgery. 9 ... ISBN 978-0-7817-7153-5. Chapter 1: Diseases of the Cardiovascular system > Section: Valvular Heart Disease Greenberg BH, Massie ... Methodist DeBakey Cardiovascular Journal. 12 (1): 20-26. doi:10.14797/mdcj-12-1-20. ISSN 1947-6094. PMC 4847963. PMID 27127558 ...
It also has anticancer effects in a variety of in vitro models. NK1 receptor antagonists Aprepitant Casopitant Fosaprepitant ... December 1996). "L-733,060, a novel tachykinin NK1 receptor antagonist; effects in [Ca2+]i mobilisation, cardiovascular and ... released substance P and calcitonin gene-related peptide in mediating mechanical hyperalgesia in a traumatic neuropathy model ...
Fluoxetine is on the WHO Model List of Essential Medicines. He later worked on cardiovascular disease and cardiac arrhythmia, ...
Azeez Pasha, a cardiovascular surgeon. Upon Dr.Pasha's insistence she embraced Islam and adopted the name Mahira. After ... When she was doing her PUC, she received her first modelling offer. She continued her studies while working as a part-time ... model. She appeared in over 60 television advertisements, the most notable being a Fastrack advertisement with John Abraham. ...
Type 2 diabetes
... cardiovascular outcomes and adverse events in patients with diabetes and cardiovascular disease or risk: A systematic review ... "Projections of type 1 and type 2 diabetes burden in the U.S. population aged ,20 years through 2050: dynamic modeling of ... The use of aspirin to prevent cardiovascular disease in diabetes is controversial. Aspirin is recommended in people at ... Chen X, Yang L, Zhai SD (December 2012). "Risk of cardiovascular disease and all-cause mortality among diabetic patients ...
LMNA - 维基百科，自由的百科全书
Molecular ageing in progeroid syndromes: Hutchinson-Gilford progeria syndrome as a model. Immun Ageing. 2009, 6: 4. PMC 2674425 ... The nuclear envelope in muscular dystrophy and cardiovascular diseases. Traffic. 2002, 2 (10): 675-83. PMID 11576443. doi: ... The A-type lamins: nuclear structural proteins as a focus for muscular dystrophy and cardiovascular diseases. Trends Cardiovasc ...
... and an incorrect model of the anatomy and physiology of internal organs. ... "Intercessory Prayer and Cardiovascular Disease Progression in a Coronary Care Unit Population: A Randomized Controlled Trial". ... Snyderman and Weil remarked that by the early twentieth century the Flexner model had helped to create the 20th-century ...
Brioche T, Pagano AF, Py G, Chopard A (April 2016). "Muscle wasting and aging: Experimental models, fatty infiltrations, and ... and decrease cardiovascular risks (Nissen et al., 2000). For all these reasons, HMB should be routinely used in muscle-wasting ... Brioche T, Pagano AF, Py G, Chopard A (April 2016). "Muscle wasting and aging: Experimental models, fatty infiltrations, and ... and decrease cardiovascular risks (Nissen et al., 2000). For all these reasons, HMB should be routinely used in muscle-wasting ...
Hematopoietic stem cell transplantation
... and found a serious cardiovascular adverse reaction rate of about 1 in 1500. This study reported a cardiovascular-related ... Mortality for allogeneic stem cell transplantation can be estimated using the prediction model created by Sorror et al., ... For this same group, severe cardiovascular events were observed with a rate of about 1 in 1500. The most common severe adverse ...
Surgery has many sub-specialties, including general surgery, ophthalmic surgery, cardiovascular surgery, colorectal surgery, ... Nosokinetics is the science/subject of measuring and modelling the process of care in health and social care systems. ... Medical nutrition therapy is done by dietitians and is prescribed for diabetes, cardiovascular diseases, weight and eating ...
These days, with the aid of CAD or modelling platforms, the work is now much faster, and this can act also as a tool for ... Of the 113 devices recalled, 35 were for cardiovascular issues. This may lead to a reevaluation of FDA procedures and ... For example, initial models of the artificial cardiac pacemaker were external support devices that transmits pulses of ...
Unit cell ball-and-stick model of lithium nitride. On the basis of size a tetrahedral structure would be expected, but ... ingestion of large amounts of potassium compounds can lead to hyperkalemia strongly influencing the cardiovascular system. ...
A colorful model for genetics, biochemistry, cell biology, and biotechnology". Plant Physiology. 126 (2): 485-93. doi:10.1104/ ... "cardiovascular system" (ID 1844), "mental state and performance" (ID 1845), and "liver, kidneys" (ID 1846) pursuant to Article ...
The inbreeding guarantees a consistent and uniform animal model for experimental purposes and enables genetic studies in ... Fareed M, Afzal M (April 2016). "Increased cardiovascular risks associated with familial inbreeding: a population-based study ... allowing for these offspring to serve as animal models for genetic studies. The use of inbred strains is also important for ... genetic studies in animal models, for example to distinguish genetic from environmental effects. The mice that are inbred ...
Models for the origin. One basic model of pleiotropy's origin describes a single gene locus to the expression of a ... cardiovascular, and nervous system, as well as the eyes and lungs. ... Other more complex models compensate for some of the basic model's oversights, such as multiple traits or assumptions about how ... was first implied by Ronald Fisher's Geometric Model in 1930. This mathematical model illustrates how evolutionary fitness ...
Alibardi, Lorenzo (2010). Morphological and cellular aspects of tail and limb regeneration in lizards a model system with ... "Reptilian cardiovascular anatomy and physiology: evaluation and monitoring (Proceedings)". dvm360.com. Retrieved 2017-04-22.. ... Paladino, F.V.; Spotila, J.R & Dodson, P. (1999): A blueprint for giants: modeling the physiology of large dinosaurs. The ... Hicks, James (2002). "The Physiological and Evolutionary Significance of Cardiovascular Shunting Patterns in Reptiles". News in ...
Some groups are modelled on twelve-step programs, while others are quite informal. Some groups advocate certain prepared foods ... 2006). "Effects of low-carbohydrate vs low-fat diets on weight loss and cardiovascular risk factors: a meta-analysis of ... Banting's pamphlet was popular for years to come, and would be used as a model for modern diets. The pamphlet's popularity ... "Comparison of 4 Diets of Varying Glycemic Load on Weight Loss and Cardiovascular Risk Reduction in Overweight and Obese Young ...
No evidence for a possible hepatic or cardiovascular toxicity was found.. History. Irreversible MAOI antidepressants were ... "Potential of moclobemide to improve cerebral insufficiency identified using a scopolamine model of aging and dementia". Acta ... Tikal K, Hrabánková M (June 1993). "[Indications for antidepressive agents in relation to diseases of the cardiovascular system ... when cardiovascular toxicity is a concern, SSRIs or the reversible MAOIs such as moclobemide are an option as they lack or have ...
Breathing - Simple English Wikipedia, the free encyclopedia
"A mathematical model of pH(i) regulation in central CO2 chemoreception". Advances in Experimental Medicine and Biology 605: 306 ... "Introduction to Respiratory & Cardiovascular Physiology. University of the West of England, Bristol. 2016. Retrieved January 29 ...
... is called the glycocalyx model, or the Michel-Weinbaum model in honour of two scientists who independently described the ... Levick, J (2010). Introduction to Cardiovascular Physiology. 5th edition. London: Hodder Arnold. p. 190. ISBN 978 0340 942 048. ... Diagram of the classic Starling model. Note that the concentration of interstitial solutes (orange) increases proportionally to ... glycocalyx model. Briefly, the interstitial fluid colloid osmotic pressure πi has been found to have no effect on Jv and the ...
Though animal models allow for more control of experimental manipulation, the effects of early life stress on HPA axis function ... cardiovascular system, immune system, reproductive system and central nervous system. The HPA axis integrates physical and ... The role of early life stress in programming the HPA Axis has been well-studied in animal models. Exposure to mild or moderate ... Several mechanisms have been proposed to explain these findings in rat models of early-life stress exposure. There may be a ...
肥胖症 - 维基百科，自由的百科全书
Expert review of cardiovascular therapy (Review). 2011-03, 9 (3): 265-77. PMID 21438803. doi:10.1586/erc.10.22.. ... Rubinstein S, Caballero B. Is Miss America an undernourished role model?. JAMA (Letter). 2000, 283 (12): 1569. PMID 10735392. ... Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss. Arterioscler. Thromb. Vasc. Biol. ( ... Obesity, metabolic syndrome, and cardiovascular disease. J. Clin. Endocrinol. Metab. 2004, 89 (6): 2595-600. PMID 15181029. doi ...
... oat fiber β-glucan decreases blood levels of LDL cholesterol and so may reduce the risk of cardiovascular diseases. β- ... 3-glucans enhance the tumoricidal activity of antitumor monoclonal antibodies in murine tumor models". Journal of Immunology. ...
A. M. Lands (1952). "The cardiovascular actions of 1-(3-aminophenyl)-2-aminoethanol and related compounds." J. Pharmacol. Exp. ... "two-compartment model", with T1/2(α) ≃ 9.7 minutes and T1/2(β) ≃ 56.4 minutes; the "plasma half-life" of N- ...
更年期 - 维基百科，自由的百科全书
Autonomic Cardiovascular Damage during Post-menopause: the Role of Physical Training. Aging and Disease. 2013, 4 (6): 320-28. ... Hormone therapy for preventing cardiovascular disease in post-menopausal women. The Cochrane Database of Systematic Reviews. ... Association of Age at Onset of Menopause and Time Since Onset of Menopause With Cardiovascular Outcomes, Intermediate Vascular ...
a b c Interpretation model - compendium at Uppsala Academic Hospital. By H. Hedenström. 2009-02-04 ... Unstable cardiovascular status (angina, recent myocardial infarction, etc.). *Thoracic, abdominal, or cerebral aneurysms ...
කොලෙස්ටරෝල් - විකිපීඩියා, නිදහස් විශ්වකෝෂය
Still, because cardiovascular disease is relatively rare in the younger population, the impact of high cholesterol on health is ... Grundy SM (2007). "Should women be offered cholesterol lowering drugs to prevent cardiovascular disease? Yes". BMJ 334 (7601): ... Kendrick M (2007). "Should women be offered cholesterol lowering drugs to prevent cardiovascular disease? No". BMJ 334 (7601): ... Given the well-recognized role of cholesterol in cardiovascular disease, it is surprising that some studies have shown an ...
Healthcare in Cuba
Cuba : A model for alternative healthcare National Foundation for Alternative medicine *^ "Cuba". World Health Organization. ... cardiovascular disease and all-cause mortality have been related to sustained population-wide weight loss as a result of ... a b Cuban Healthcare: An analysis of a Community-based model Essam Farag online ... An Enduring Model; Health, Politics, and Revolution in Cuba Since 1898; Primary Health Care in Cuba: The Other Revolution; ...
High-altitude cerebral edema
Animal models of HACE have not been developed. Several genes are being examined for the role they may play in the ... Progress in Cardiovascular Diseases. 52 (6): 467-484. doi:10.1016/j.pcad.2010.02.003. PMID 20417340.. ...
Fruit and vegetables for kids
Be a strong role model and have lots of vegetables on your plate at meal times. Involve children in meal preparation so they ... gastrointestinal and cardiovascular systems (Deen & Hark, 2007) Assist in the release of energy from foods through the ...
فهرست یهودیان برنده جایزه نوبل - ویکیپدیا، دانشنامهٔ آزاد
"for the creation of econometric models and the application to the analysis of economic fluctuations and economic policies" ... "for their discoveries concerning نیتریک اکسید as a signalling molecule in the cardiovascular system" ... which have been of essential importance for the development of the quark model in particle physics" ...
For athletes and sports enthusiasts, this eccentric model can help with explosive force training in order to ... Cardiovascular changes. Several recent studies have indicated that eccentric exercise as in walking down hill has greater ... One study used stairs and elevators  and the other a mountain and a cable car. In both cases the cardiovascular ...
Chronic obstructive pulmonary disease
Churg A, Wright JL (2007). "Animal models of cigarette smoke-induced chronic obstructive lung disease". Models of Exacerbations ... "Morbidity & Mortality: 2009 Chart Book on Cardiovascular, Lung, and Blood Diseases" (PDF). National Heart, Lung, and Blood ... Wright JL, Churg A (December 2002). "Animal models of cigarette smoke-induced COPD". Chest. 122 (6 Suppl): 301S-306S. doi: ... Singh S, Loke YK, Furberg CD (September 2008). "Inhaled anticholinergics and risk of major adverse cardiovascular events in ...
Animal Models of Cardiovascular Diseases
Mouse Models. The mouse has become the preferred model for cardiovascular research for several reasons, including the ease of ... Animal models of cardiovascular disease yield important insights into the genetic basis of human cardiovascular diseases and ... This new model is yielding promising results .. 4.3. Large Animal Models of Heart Failure. Small animal models have ... Here we will describe models of atherothrombotic diseases, including expanding and occlusive animal models, as well as models ...
3D Cardiovascular Models | TurboSquid
3D cardiovascular models for download, files in 3ds, max, c4d, maya, blend, obj, fbx with low poly, animated, rigged, game, and ... Free 3D Models 3ds Max Models Maya Models Cinema 4D Models Blender Models ... Top 3D Model Categories. Airplane Anatomy Animal Architecture Car Characters Food & Drink Furnishings Industrial Interior ...
Webinar: Mouse Models of Cardiovascular Disease
Our mouse model repository maintains hundreds of mouse models to accelerate research in coronary heart disease (including, ... Cardiovascular disease is the leading cause of morbidity and mortality worldwide. ... Webinar: Mouse Models of Cardiovascular Disease Cardiovascular disease is the leading cause of morbidity and mortality ... Published data characterizing key mouse models of cardiovascular disease. *Strain-specific details about disease onset, ...
Cardiovascular Flow Modeling Laboratory - Purdue University
Welcome to the Cardiovascular Flow Modeling Laboratory. The mission of the Cardiovascular Flow Modeling Laboratory (CFM Lab) is ... Nazanin Maanis paper on modeling Chemofilter device is published in Biomechanics and Modeling in Mechanobiology ... These models provide clinicians with valuable quantitative data not available from medical imaging alone. While the main focus ... In our studies, image-based computational fluid dynamics (CFD) models are used to determine hemodynamic variables related to ...
medical cardiovascular stent 3d model
... the worlds leading provider of digital 3D models for visualization, films, television, and games. ... Cardiovascular stent 3D Model available on Turbo Squid, ... Medical models of cardiovascular stent inside blood vessel. ... cardiovascular cardio stent blood heart cell vessel fat medical equipment procedure cross section anatomy ... High resolution model created in 3ds max 2014 rendered with vray materials and particle flow simulation of the blood cells. ...
Prediction models for cardiovascular disease risk in the general population: systematic review | The BMJ
We found much variability in geographical location of both model development and model validation, but the majority of models ... of the developed models, the modelling method was not described, for 13% the time horizon (eg, 10 years) for which the model ... models; however, 250 (69%) models were explicitly developed only for men or only for women. Most of the models (n=239, 66%) ... and the models performance before and (if conducted) after model recalibration. If an article described multiple models, we ...
Developing cardiovascular risk prediction models for Australia | The Medical Journal of Australia
Ideally, a CVD risk score model for patients in Australia should be based upon a large Australian cohort study including ... An absolute risk approach to managing cardiovascular disease (CVD) risk factors is superior to managing individual risk factors ... Risk stratification is the best strategy for deciding who needs medication for primary prevention of cardiovascular events ...
A coupled hydrodynamic model of the cardiovascular and cerebrospinal fluid system. - PubMed - NCBI
... cardiovascular tree model was constructed including a simplified SC arterial network. Connection between the cardiovascular and ... A coupled hydrodynamic model of the cardiovascular and cerebrospinal fluid system.. Martin BA1, Reymond P, Novy J, Balédent O, ... A coupled cardiovascular and CSF system model was designed to examine the relation of spinal cord (SC) blood flow (SCBF) and ... The 1-D tube model of the SSS resulted in a distribution of CSF pressure and flow and a wave speed that were similar to those ...
Assessment of Cardiovascular Disease Risk Models Using Primary Care Data - UEA
Assessment of Cardiovascular Disease Risk Models Using Primary Care Data/. Assessment of Cardiovascular Disease Risk Models ... the standard Framingham model, and the more recent ASSIGN and QRISK models. The latest model, QRISK, was developed using a ... In this project such data was used to assess cardiovascular disease risk models. ... Many of the risk factors predisposing people to CVD are known, and there are a number of survival models to identify those who ...
Uncertainty Quantification and Sensitivity Analysis for Cardiovascular Models | Simula Research Laboratory
... with cardiovascular models. In a comprehensive guide to UQ and SA, we showed how to quantify the uncertainties of model ... How certain are the predictions of a cardiovascular model, taking the natural variations and measurement uncertainty of model ... The major challenge for applying cardiovascular models in personalized medicine is as follows: ... Furthermore, we developed a framework for UQ and SA in a one-dimensional blood flow model, which can be applied for patient- ...
Computational fluid dynamics modelling in cardiovascular medicine | Heart
... in silico models) of the cardiovascular system in health and disease. CFD modelling is a new field within cardiovascular ... Benefits of cardiovascular CFD modelling. CFD modelling enables investigation of pressure and flow fields at a temporal and ... Patient-specific modeling of cardiovascular mechanics. Annu Rev Biomed Eng 2009;11:109-34. doi:10.1146/annurev.bioeng.10.061807 ... Review of zero-D and 1-D models of blood flow in the cardiovascular system. Biomed Eng Online 2011;10:33. doi:10.1186/1475-925X ...
Clinical Prediction Models for Cardiovascular Disease: Tufts Predictive Analytics and Comparative Effectiveness Clinical...
Clinical Prediction Models for Cardiovascular Disease: The Tufts PACE CPM Database. Circ Cardiovasc Qual Outcomes. ;8(4):368- ... Clinical Prediction Models for Cardiovascular Disease: The Tufts PACE CPM Database. Circ Cardiovasc Qual Outcomes. ;8(4):368- ... Clinical Prediction Models for Cardiovascular Disease: The Tufts PACE CPM Database. Circ Cardiovasc Qual Outcomes. ;8(4):368- ... Clinical Prediction Models for Cardiovascular Disease: Tufts Predictive Analytics and Comparative Effectiveness Clinical ...
Cardiovascular Disease in COPD: Evidences from Epidemiology, Genetics, Bio-Markers, Animal Models, Clinical Studies &...
Cardiovascular Disease in COPD: Evidences from Epidemiology, Genetics, Bio-Markers, Animal Models, Clinical Studies & ... Cardiovascular Disease in COPD: Evidences from Epidemiology, Genetics, Bio-Markers, Animal Models, Clinical Studies & ... Large cardiovascular and COPD trials of agents that might plausibly affect both conditions and that include co-morbid subjects ... Experts in cardiovascular disease and COPD were brought together for this working group. It was acknowledged that ...
Measurement Error Case Series Models With Application to Infection-Cardiovascular Risk in Older Patients on Dialysis
However, a major challenge in modeling/assessing the infection-cardiovascular risk hypothesis is that the exact time of ... Our recent work found an increase in the relative incidence of cardiovascular outcomes during the ∼ 30 days after infection- ... related hospitalizations using the case series model, which adjusts for measured and unmeasured baseline confounders. ... Infection and cardiovascular disease are leading causes of hospitalization and death in older patients on dialysis. ...
Beating Heart Surgery Systems (Cardiovascular) - Global Market Analysis and Forecast Model (COVID-19 market impact)
Global Market Analysis and Forecast Model (COVID-19 market impact) is built to visualize quantitative market trends within ... Cardiovascular Devices therapeutic area.New York, July 31, 2020 (GLOBE NEWSWIRE) -- Reportlinker.com announces the release ... This Market Model gives important, expert insight you wont find in any other source. The model illustrates qualitative and ... Summary Beating Heart Surgery Systems (Cardiovascular) - Global Market Analysis and Forecast Model (COVID-19 market impact) is ...
Effectiveness and cost effectiveness of cardiovascular disease prevention in whole populations: modelling study | The BMJ
Modelling the UK burden of cardiovascular disease to 2020: a research report for the Cardio & Vascular Coalition and the ... Model Spreadsheet model to quantify the reduction in cardiovascular disease over a decade, assuming the benefits apply ... Our spreadsheet model allows a relative risk to be applied to each years risk of primary cardiovascular disease in the ... The model focuses on primary prevention of cardiovascular disease. All population-wide risk factor reduction programmes ...
Apolipoproteins in Animal Models of Cardiovascular Disease | Taconic Biosciences
... and therefore targets of interest in preclinical cardiovascular disease drug discovery. ... Mouse Model. Taconic Model #. Roles in Cardiovascular Disease. Apoe mouse. APOE. Lacks the ApoE protein, results in five times ... Apolipoproteins in Animal Models of Cardiovas.... Apolipoproteins in Animal Models of Cardiovascular Disease. Caroline Horizny ... Animal Models of Cardiovascular Disease. Many research needs can be addressed by animal models that either over- or under- ...
Cardiovascular Adaptations Induced by Resistance Training in Animal Models
... Author. Target tissue. Duration. Intensity. Model. ... are RT models most commonly used in animals to study the cardiovascular system after the model by Tamaki et al. . ... Cardiovascular adaptations in rats submitted to a resistance-training model. Clin Exp Pharmacol Physiol. 2005;32:249-54 ... Cardiovascular Adaptations Induced by Resistance Training in Animal Models S.F.S. Melo1,2, N.D. da Silva Júnior2, V.G. Barauna1 ...
Risk models for cardiovascular disease could be misleading, finds study | News Article | Pulse Today
Current risk prediction models for cardiovascular disease may be misleading at the individual level because of large variations ... Current risk prediction models for cardiovascular disease may be misleading at the individual level because of large variations ... The model gives you an estimate but our findings suggest you need to take that with a pinch of salt because there could be wide ... in the incidence of cardiovascular disease and when we looked further that wasnt taken into account by the QRISK model. ...
New Cardiovascular Risk Prediction Models Developed for Women ( Researchers have developed a more accur...)
Cardiovascular,Risk,Prediction,Models,Developed,for,Women,medicine,medical news today,latest medical news,medical newsletters, ... New Cardiovascular Risk Prediction Models Developed for Women. Researchers have developed a more accurate way to predict the ... New Guidelines Found To Benefit Cardiovascular Treatment. 6. Women With A High-Risk Of Cardiovascular Disease Under treated 7. ... High iron levels may cause Cardiovascular Disease in women. 2. Air Pollution said To Increase Risk of Cardiovascular Disease. 3 ...
Animal Models: Dosimetry, and Pulmonary and Cardiovascular Events | Research Project Database | Grantee Research Project...
Animal Models: Dosimetry, and Pulmonary and Cardiovascular Events. EPA Grant Number: R827354C004. Subproject: this is ... animal model, dosimetry, pulmonary, cardiovascular, ultrafine carbon particle, UFP, particulate matter, PM, electrocardiogram, ... Title: Animal Models: Dosimetry, and Pulmonary and Cardiovascular Events. Investigators: Oberdörster, Günter , Couderc, Jean- ... R827354C004 Animal Models: Dosimetry, and Pulmonary and Cardiovascular Events. R827354C005 Ultrafine Particle Cell Interactions ...
Replacing Vascular Corrosion Casting by In Vivo Micro-CT Imaging for Building 3D Cardiovascular Models in Mice | SpringerLink
Replacing Vascular Corrosion Casting by In Vivo Micro-CT Imaging for Building 3D Cardiovascular Models in Mice. ... Reardon CA, Getz GS (2001) Mouse models of atherosclerosis. Curr Opin Lipidol 12:167-173CrossRefPubMedGoogle Scholar ... Casteleyn C, Trachet B, Van Loo D et al (2010) Validation of the murine aortic arch as a model to study human vascular diseases ... Fenestra In vivo Micro-CT Mice Vascular corrosion casting 3D model Wall shear stress ...
New model for predicting cardiovascular disease risk worldwide | News | Harvard T.H. Chan School of Public Health
New model for predicting cardiovascular disease risk worldwide. For immediate release: March 25, 2015 ... To develop the model, which will be available later this year at www.globorisk.org, the researchers analyzed data from more ... This finding comes from a research team that developed the first global model for predicting CVD risk at a nation-by-nation ... The risk of developing fatal cardiovascular disease over a 10-year period is highest in countries including China, Mexico, and ...
Genetically modified animal models in cardiovascular research | Revista Española de Cardiología
Genetically modified animal models in cardiovascular research. Florence Dalloz a, Hanna Osinka a, Jeffrey Robbins a. a ... To understand these relationships, and to establish models in which the pathogenic processes can be studied longitudinally, it ... Department of Pediatrics, Division of Molecular Cardiovascular Biology, Children´s Hospital Research Foundation, Cincinnati OH ...
Mathematical Modeling of Cardiovascular Systems: From Physiology to the Clinic | Frontiers Research Topic
Physics-based mathematical modeling is well tailored for the task when the number of variables is so great that it eludes ... Most FE models concerned with heart disease include only the left ventricular (LV) heart chamber because it is under the ... Applications of mathematical models have ranged from understanding basic biological system to generate new hypotheses to ... Here, we focus on the cardiovascular system which includes the heart and blood vessels as this discipline has been at the ...
CI2BM09 - MICCAI Workshop on Cardiovascular Interventional Imaging and Biophysical Modelling - Home
Lecturer in Cardiovascular Modelling. Division of Imaging Sciences. Kings College London. St Thomas Hospital. London Pr. ... Recent advances in the development of biophysical modelling have lead to one of the most advanced examples of organ modelling ... and clinicians to discuss and challenge the frontiers of cardiovascular interventional imaging and biophysical modelling. The ... Multi-scale models of coronary perfusion *Ergin Atalar, Bilkent University, Ankara, Turkey: Catheters for stem cell delivery * ...
Homeostasis Model Assessment of Insulin Resistance in Relation to the Incidence of Cardiovascular Disease | Diabetes Care
Homeostasis Model Assessment of Insulin Resistance in Relation to the Incidence of Cardiovascular Disease. The San Antonio ... Homeostasis Model Assessment of Insulin Resistance in Relation to the Incidence of Cardiovascular Disease ... Homeostasis Model Assessment of Insulin Resistance in Relation to the Incidence of Cardiovascular Disease ... Homeostasis Model Assessment of Insulin Resistance in Relation to the Incidence of Cardiovascular Disease ...
Abstract 2273: Cardiovascular Changes after Exposure to Hydrogen Sulfide in a Murine Model | Circulation
Abstract 2273: Cardiovascular Changes after Exposure to Hydrogen Sulfide in a Murine Model. Gian Paolo Volpato, Robert J ... Abstract 2273: Cardiovascular Changes after Exposure to Hydrogen Sulfide in a Murine Model ... Abstract 2273: Cardiovascular Changes after Exposure to Hydrogen Sulfide in a Murine Model ... Abstract 2273: Cardiovascular Changes after Exposure to Hydrogen Sulfide in a Murine Model ...
Improving access and equity in reducing cardiovascular risk: the Queensland Health model | The Medical Journal of Australia
Improving access and equity in reducing cardiovascular risk: the Queensland Health model. ... We analysed cardiovascular risk factor data collected prospectively as part of TCP. The audit data included: blood test results ... 2 Comparison of cardiovascular risk factors from entry to completion of The COACH Program in participants with coronary heart ... 3 Comparison of cardiovascular risk factors from entry to completion of The COACH Program in participants with type 2 diabetes ...
Projected Impact of Mexico's Sugar-Sweetened Beverage Tax Policy on Diabetes and Cardiovascular Disease: A Modeling Study
Studied cardiovascular diseaseDiseasesMortalityImagingCardiacMathematicalPredictiveSystemConclusionsMethodsClinicalChronic ObstrucCoronary heart disease andPrediction Models for Cardiovascular DiseaseStudyAtherosclerosisSimulationPreventionCirculationStentAorticMagnetic resonanceOutcomesPhysiologicalComputational fluid dyDeath from cardiovascular diseaseDeathsMechanismsTreatment of cardiovascular diseaseAssessmentPopulationsEpidemiologyRisk factorsExperimentalIncidenceEpidemiologicalAutonomicOutcomePredictVisualize quantitative market trendsHeart failureLaboratoryPatients with cardiovascularStrokeVascularBlood flowField of cardiovascularDevelopment of cardiovascularPredictorsArterialPulmonary2016MyocardialPredictsBiomarkers
Studied cardiovascular disease1
- He began in the Laboratory of Dr. Beverly Paigen, where he studied cardiovascular disease. (jax.org)
- Cardiovascular diseases are the first leading cause of death and morbidity in developed countries. (hindawi.com)
- Several models have been developed to address cardiovascular complications, including atherothrombotic and cardiac diseases, and the same pathology have been successfully recreated in different species, including small and big animal models of disease. (hindawi.com)
- Here we will describe models of atherothrombotic diseases, including expanding and occlusive animal models, as well as models of heart failure. (hindawi.com)
- Given the wide range of models available, today it is possible to devise the best strategy, which may help us to find more efficient and reliable solutions against human cardiovascular diseases. (hindawi.com)
- The development of animal models of cardiovascular disease (CVD), including cardiac and atherothrombotic diseases, has provided us today with important insights into the pathophysiology, and they were found to be essential tools to evaluate new therapeutic strategies to predict and to prevent these complications. (hindawi.com)
- Here, we will summarize the most common models of cardiovascular diseases, including those implemented in both large and small animals, designed for helping to cover with more precision and to better understand every single aspect related to these human pathologies. (hindawi.com)
- In particular, we will describe models of atherothrombotic diseases, including expanding abdominal aortic aneurysms (AAA), thoracic aneurysms, and occlusive atherosclerotic diseases, as well as models of heart failure. (hindawi.com)
- CFD models are now being translated into clinical tools for physicians to use across the spectrum of coronary, valvular, congenital, myocardial and peripheral vascular diseases. (bmj.com)
- Cardiovascular diseases (principally coronary heart disease and stroke) together account for more than 150 000 deaths a year in the United Kingdom. (bmj.com)
- In 2005 our group were the first to use the same apparatus to examine the cardiovascular system and after that the number of studies using this model have grown to investigate the effects of the RT as non-pharmacological therapy for the treatment or prevention of the many different cardiovascular diseases [ 8 - 10 ]. (medsci.org)
- This would allow one to study the early development of cardiovascular diseases. (springer.com)
- Our mission is to build healthier lives, free of cardiovascular diseases and stroke. (ahajournals.org)
- In 2009, Queensland Health introduced The COACH (Coaching Patients On Achieving Cardiovascular Health) Program (TCP) to assist people diagnosed with chronic diseases and to reduce the risk of future complications. (mja.com.au)
- Is the Subject Area "Cardiovascular diseases" applicable to this article? (plos.org)
- Cardiovascular diseases are the leading cause of human death and disability in the world, responsible for an estimated of 17.5 million deaths in 2012, which accounted for 31% of the total global human mortality [ 8 , 9 ]. (omicsonline.org)
- Decision Support Systems for Cardiovascular Diseases Based on Data Mining and Fuzzy Modelling. (igi-global.com)
- This article addresses the decision support regarding cardiovascular diseases, using computer-based methods, focusing on the coronary artery disease (CAD) diagnosis and on the prediction of clinical restenosis in patients undergoing angioplasty. (igi-global.com)
- In this vein, iPSCs have been used to model an array of cardiovascular diseases, including cardiomyopathies, rhythmic disorders, vascular disease, and metabolic factors associated with heart disease. (heart.org)
- The objective of this study is to estimate the number of deaths attributable to cardiovascular diseases and diet-related cancers that could be prevented or delayed in the Nordic countries, i.e. (mdpi.com)
- Data included in the model are a baseline scenario (actual dietary intake), a counterfactual scenario (recommended intake), and age-and sex-specific mortality for cardiovascular and diet-related cancer diseases, together with the total population risk of a specific year. (mdpi.com)
- Moreover, recent advances in 3D histotypic and organotypic cultures have escalated the impact and scope in the studies of cardiovascular development, diseases, and therapies. (frontiersin.org)
- Although treatment options are constantly improving, cardiovascular diseases are still one of the most frequent causes of death in Europe. (medica-tradefair.com)
- Cardiovascular diseases (CVDs) are the leading cause of death and disability both in the United States and worldwide. (jhu.edu)
- The Chronic Care Model (CCM) achieved widespread acceptance and reflects the core elements of patient-centred care in chronic diseases such as CVD and COPD. (biomedcentral.com)
- The model provides a multidisciplinary approach to care for patients with chronic diseases, which involves the community and healthcare system and fosters communication between clinicians and well-informed patients. (biomedcentral.com)
- Can radiation increase the risk of cardiovascular diseases? (nii.ac.jp)
- The known health-related properties of onion have revealed its promising value in the prevention of risk factors and reduction of symptoms associated to several diseases, including cardiovascular disease (CVD) and liver disease. (ucm.es)
- These models provide valuable tools in examining and understanding cardiovascular diseases. (koreascience.or.kr)
- Cardiovascular disease (CVD) is a class of diseases that involve the heart or blood vessels. (wikipedia.org)
- Cardiovascular diseases are the leading cause of death worldwide except Africa. (wikipedia.org)
- There are many cardiovascular diseases involving the blood vessels. (wikipedia.org)
- Coronary artery disease (also known as coronary heart disease and ischemic heart disease) Peripheral arterial disease - disease of blood vessels that supply blood to the arms and legs Cerebrovascular disease - disease of blood vessels that supply blood to the brain (includes stroke) Renal artery stenosis Aortic aneurysm There are also many cardiovascular diseases that involve the heart. (wikipedia.org)
- Cardiovascular disease is the leading cause of morbidity and mortality worldwide. (jax.org)
- Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide, 1 accounting for approximately one third of all deaths. (bmj.com)
- Medical imaging has a front-line role for the diagnosis and treatment of cardiovascular disease (CVD), one of the leading worldwide causes of morbidity and mortality and a significant healthcare burden. (inria.fr)
- Cardiovascular disease (CVD) accounts for half of the total mortality among individuals with type 2 diabetes ( 1 ), and the risk of a first myocardial infarction (MI) among subjects with diabetes approximates that for reinfarction among nondiabetic patients with a previous MI ( 2 ). (diabetesjournals.org)
- Meta-analyses of BP trials using high doses of diuretics showed the epidemiologically predicted reduction of stroke but a less than expected effect on cardiovascular mortality ( 6, 7 ). (aacrjournals.org)
- Only when the dose was lowered (e.g., 12.5-25 mg of chlorthalidone) was the full epidemiologically predicted benefit of BP control on cardiovascular mortality seen ( 8 ). (aacrjournals.org)
- Traditional risk factors, burden of disease, lack of treatment, and geographic location all are related to an increased risk of subsequent cardiovascular morbidity and cardiovascular mortality. (acc.org)
- Cardiovascular calcification is prevalent in the aging population and in patients with chronic kidney disease (CKD) and diabetes mellitus, giving rise to substantial morbidity and mortality. (mdpi.com)
- Despite high morbidity, mortality, and cost in the US and global healthcare systems, cardiovascular care has been under-studied in the healthcare operations management literature. (jhu.edu)
- A joint model analysis was used to investigate the association between each longitudinal lipid markers and CVD mortality in men, women and pooled sample. (magiran.com)
- Setting The model combined publicly available data on F&V trade, published estimates of UK-specific price elasticities, national survey data on F&V intake, estimates on the relationship between F&V intake and CVD from published meta-analyses and CVD mortality projections for 2021-2030. (bmj.com)
- Our model suggests that a no-deal Brexit scenario would be the most harmful, generating approximately 12 400 (6690 to 23 390) extra CVD deaths between 2021 and 2030, whereas establishing a free trading agreement with the EU would have a lower impact on mortality, contributing approximately 5740 (2860 to 11 910) extra CVD deaths. (bmj.com)
- Conclusions Trade policy under all modelled Brexit scenarios could increase price and decrease intake of F&V, generating substantial additional CVD mortality in England. (bmj.com)
- Several studies have shown an association between each of these models and mortality. (biomedcentral.com)
- The purpose of the present study was to study the relation between socioeconomic position (SEP) and mortality using different conceptual models in the whole population of Scania. (biomedcentral.com)
- Focusing on three specific life periods (i.e., ages 10-15, 30-35 and 40-45), we examined the association between SEP and the 12-year risk of premature cardiovascular mortality and all-cause mortality. (biomedcentral.com)
- There was a strong relation between SEP and mortality among those inside the workforce, irrespective of the conceptual model used. (biomedcentral.com)
- 0.001 for both cardiovascular and all-cause mortality) and women (p for trend = 0.01 for cardiovascular mortality) and (p for trend = 0.003 for all-cause mortality). (biomedcentral.com)
- When applying similar conceptual models based on workforce participation, it was shown that mortality was affected by the accumulated exposure to being outside the workforce. (biomedcentral.com)
- That is, one model could not be pointed out as "the best" model and even in this large unselected sample it was not possible to adjudicate which theories best describe the links between life course SEP and mortality risk. (biomedcentral.com)
- Modelling the impact of alcohol consumption on cardiovascular disease mortality for comparative risk assessments: an overview. (drugsandalcohol.ie)
- Methods: Risk assessment modelling with alcohol-attributable CVD mortality as primary outcome. (drugsandalcohol.ie)
- Objectives We sought to develop and evaluate a risk adjustment model for in-hospital mortality following percutaneous coronary intervention (PCI) procedures using data from a large, multi-center registry. (onlinejacc.org)
- Conclusions A risk adjustment model for in-hospital mortality after PCI was successfully developed using a contemporary multi-center registry. (onlinejacc.org)
- This model is an important tool for valid comparison of in-hospital mortality after PCI. (onlinejacc.org)
- Cardiac surgeons addressed the problems associated with the publication in the late 1980s of unadjusted surgical mortality results in New York and other states by forming the Society of Thoracic Surgeons National Database and developing risk adjustment models for coronary artery bypass graft (CABG) surgical mortality (1-4) . (onlinejacc.org)
- In this research, computational and experimental modeling is combined with medical imaging in order to provide patient-specific flow analysis. (purdue.edu)
- These models provide clinicians with valuable quantitative data not available from medical imaging alone. (purdue.edu)
- Combined with cardiovascular imaging, CFD simulation enables detailed characterisation of complex physiological pressure and flow fields and the computation of metrics which cannot be directly measured, for example, wall shear stress. (bmj.com)
- The coupling of imaging and biophysical modelling is opening up new avenues for the validation, testing, and clinical application of biophysical models for the planning and delivery of treatments for CVD. (inria.fr)
- This workshop will bring together a multi-disciplinary group consisting of engineers, computer scientists, mathematicians, and clinicians to discuss and challenge the frontiers of cardiovascular interventional imaging and biophysical modelling. (inria.fr)
- The Role of Computer Modeling, Optical Imaging and. (sunnybrook.ca)
- The computer model is parametrized with anatomical information and fibre directions obtained via MR imaging. (sunnybrook.ca)
- Biomechanical modeling of bifurcation stenting involves computational simulations and in vitro bench testing using subject-specific arterial geometries obtained from in vivo imaging. (onlinejacc.org)
- Methods and Results- The feasibility of cardiovascular magnetic resonance (CMR) imaging with magneto-fluorescent nanoparticles (MNPs) for detection of myocarditis and its effectiveness in discriminating inflammation grades were assessed in experimental autoimmune myocarditis (EAM) (n=65) and control (n=10) rats. (ahajournals.org)
- It can hardly be argued that cardiac imaging methodologies targeting small-animal models have been crucial for rapidly transitioning therapies from bench to bedside. (onlinejacc.org)
- The adaptation of ultrasound for imaging murine hearts, for example, has allowed characterization of the developing and adult rodent heart, making it an essential tool for the study of developmental biology and cardiovascular disease. (onlinejacc.org)
- Hence, we present the first study aimed to directly compare this novel imaging modality with both conventional echocardiography and conductance catheter (CC) measurement techniques using an established murine model of ischemic heart disease. (onlinejacc.org)
- In this study, we present a novel model-based imaging method to enable high-resolution real-time PC-CMR with sparse sampling. (harvard.edu)
- We further integrate this formulation with the SENSE-based parallel imaging model to handle multichannel acquisitions. (harvard.edu)
- In: van Assen H., Bovendeerd P., Delhaas T. (eds) Functional Imaging and Modeling of the Heart. (springer.com)
- Whereas many of the relevant fluid dynamic quantities are difficult, if not impossible, to measure clinically, recent advances in computational modelling, medical imaging, physical modelling techniques and laboratory instrumentation afford researchers and clinicians the means to model the cardiovascular system with greater fidelity than ever before. (strath.ac.uk)
- Large cardiovascular and COPD trials of agents that might plausibly affect both conditions and that include co-morbid subjects should routinely include both cardiac and pulmonary endpoints (such as cardiac events and COPD exacerbation rate) as outcome variables. (nih.gov)
- In the subsequent sections we will review the information regarding cardiac morphological adaptations, signaling pathway of the cardiac cell, cardiac function and the vascular adaptation induced by RT using this animal model developed by Tamaki et al. (medsci.org)
- The number of vascular beds with clinical disease, diabetes, smoking, low body mass index, history of atrial fibrillation, cardiac failure, and history of cardiovascular event(s) 1 year before baseline examination increased risk of a subsequent cardiovascular event. (acc.org)
- For example, the engineered heart tissue/muscle and cardiovascular spheroids have shown great promises in the in vitro modelling of familial cardiomyopathies, cardiovascular toxicity assessment, drug discovery, and in vivo cardiac regeneration (i.e., cardiac patch). (frontiersin.org)
- This often results in lower acquisition efficiency, and limited utility in the presence of cardiovascular pathology (e.g., cardiac arrhythmia). (harvard.edu)
- The SIMULIA Living Heart Human Model provides a unique testing environment where a stent can be deployed virtually in coronary arteries and deformed mechanically during the cardiac cycle. (drugdiscoveryonline.com)
- Cardiac repair in a porcine model of acute myocardial infarction with human induced pluripotent stem cell-derived cardiovascular cells. (biomedsearch.com)
- These findings in a large animal MI model highlight the potential of utilizing hiPSC-derived cells for cardiac repair. (biomedsearch.com)
- In this model CMS proposes to add cardiac care as an extension of the existing bundled payment program for hip replacements. (scct.org)
- The model would also include a program to increase cardiac rehabilitation utilization. (scct.org)
- Computational techniques, including spectral analysis of HRV and a model which characterizes the dynamics of baroreflex and respiratory-cardiac coupling, were used to assess cardiovascular autonomic control in SCD patients and normal control (CTL) subjects. (usc.edu)
- In addition to the HRV analysis, model-based assessment also revealed the absence of both arterial baroreflex and respiratory-cardiac coupling augmentations in SCD patients during the cold face stimulus, while in CTL subjects both mechanisms showed tendencies to increase during the test. (usc.edu)
- Stress equilibrium is imposed in weak form and the resulting force balance equations are coupled to a lumped-parameter model of the circulation, leading to a system of differential-algebraic equations, whose numerical solution yields predictions of LV pressure and volume, together with spatial distributions of stresses and strains throughout the cardiac cycle. (deepdyve.com)
- Physics-based mathematical modeling is well tailored for the task when the number of variables is so great that it eludes intuition. (frontiersin.org)
- The past several decades have enjoyed enormous advancements in mathematical modeling as computational capabilities have advanced substantially and experimental databases to inform and calibrate the computational models have become available to reduce ad hoc assumptions. (frontiersin.org)
- Applications of mathematical models have ranged from understanding basic biological system to generate new hypotheses to patient-specific computational models that can aid medical diagnosis and help design optimal treatments. (frontiersin.org)
- Furthermore, the progress of mathematical models remains largely unrecognized in the clinic. (frontiersin.org)
- The objective of this Research Topic is to place the spotlight on integration with emphasis on clinical translation of mathematical models. (frontiersin.org)
- Since regional heart wall stress cannot be measured reliably, mathematical modeling based on the conservation laws of continuum mechanics is needed. (frontiersin.org)
- SIMCARD is an interdisciplinary project that develops, analyzes, and simulates mathematical models of the cardiovascular system. (utaustinportugal.org)
- Mathematical models have helped greatly in the understanding of the causes of recurrent apnoeas. (nih.gov)
- Mathematical models show that periodic breathing is a 'systems disorder' produced by the interplay of multiple factors. (nih.gov)
- Yet, automated critical care systems developed by researchers are ad-hoc, because they determine the control law, i.e., drug infusion rate, using input-output observations rather than the insights on the patient's physiological states gained from rigorous data-based analysis of mathematical models. (umd.edu)
- This necessitates dose-response mathematical models capable of reproducing realistic physiological and dose-mediated states with reasonable computational load. (umd.edu)
- To address these challenges, we believe that a hybrid physiologic-phenomenological modeling paradigm is effective in developing mathematical models for automated systems: low-order phenomenological models with adaptive personalization capability are suited to develop control algorithms, while physiological models can provide high-fidelity patterns with physiological transparency suited to interpret the underlying physiological states. (umd.edu)
- A new mathematical model of pumping heart coupled to lumped compartments of blood circulation is presented. (koreascience.or.kr)
- The Guyton model of fluid, electrolyte, and circulatory regulation is an extensive mathematical model of human circulatory physiology, capable of simulating a variety of experimental conditions, and contains a number of linked subsystems relating to circulation and its neuroendocrine control. (cellml.org)
- Clinical Prediction Models for Cardiovascular Disease: Tufts Predictive Analytics and Comparative Effectiveness Clinical Prediction Model Database. (nih.gov)
- The authors note that although understanding of cardiovascular disease has changed dramatically in the past half-century, the algorithms (predictive models) for women are largely unchanged from those recommended 40 years ago. (bio-medicine.org)
- The widespread availability of new computational methods and tools for data analysis and predictive modelling requires medical informatics researchers and practitioners to systematically select the most appropriate strategy to cope with clinical prediction problems. (igi-global.com)
- Many individual biomarkers have been shown to be predictive of cardiovascular outcomes in patients with stable and unstable vascular disease. (acc.org)
- We have reviewed the historical development and principles of prediction research, including their statistical underpinning, as well as implications for routine practice, with a focus on predictive modelling for CVD and diabetes. (elsevier.com)
- Predictive modelling for CVD risk, which has developed over the last five decades, has been largely influenced by the Framingham Heart Study investigators, while it is only ∼20 years ago that similar efforts were started in the field of diabetes. (elsevier.com)
- Identification of predictive factors is an important preliminary step which provides the knowledge base on potential predictors to be tested for inclusion during the statistical derivation of the final model. (elsevier.com)
- Patient factors were more predictive in the MI model, while lesion and procedural factors were more predictive in the analysis of non-MI patients. (onlinejacc.org)
- These models were then discovered to also have effects on the cardiovascular system, some of them unanticipated. (springer.com)
- Arias-Loza PA, Jazbutyte V, Pelzer T. Genetic and pharmacologic strategies to determine the function of estrogen receptor alpha and estrogen receptor beta in cardiovascular system. (springer.com)
- A coupled hydrodynamic model of the cardiovascular and cerebrospinal fluid system. (nih.gov)
- Coupling of the cardiovascular and cerebrospinal fluid (CSF) system is considered to be important to understand the pathophysiology of cerebrovascular and craniospinal disease and intrathecal drug delivery. (nih.gov)
- A coupled cardiovascular and CSF system model was designed to examine the relation of spinal cord (SC) blood flow (SCBF) and CSF pulsations along the spinal subarachnoid space (SSS). (nih.gov)
- Connection between the cardiovascular and CSF system was accomplished by a transfer function based on in vivo measurements of CSF and cerebral blood flow. (nih.gov)
- Pressure and flow throughout the cardiovascular and CSF system were determined for different values of craniospinal compliance. (nih.gov)
- Furthermore, we developed a framework for UQ and SA in a one-dimensional blood flow model, which can be applied for patient-specific simulations of the cardiovascular system under healthy and diseased conditions. (simula.no)
- CFD, a specialist area of mathematics and a branch of fluid mechanics, is used routinely in a diverse range of safety-critical engineering systems, which increasingly is being applied to the cardiovascular system. (bmj.com)
- 2 , 3 CFD-based techniques are being used to build complex computer representations (in silico models) of the cardiovascular system in health and disease. (bmj.com)
- In the last 10 years the number of studies showing the benefits of resistance training (RT) to the cardiovascular system, have grown. (medsci.org)
- In comparison to aerobic training, RT-induced favorable adaptations to the cardiovascular system have been ignored for many years, thus the mechanisms of the RT-induced cardiovascular adaptations are still uncovered. (medsci.org)
- In this context, our group began to investigate the effects of RT on the cardiovascular system in rats. (medsci.org)
- Here, we focus on the cardiovascular system which includes the heart and blood vessels as this discipline has been at the frontier of computational modeling both for understanding physiology and disease. (frontiersin.org)
- However, the impact of H 2 S on the cardiovascular system is unknown. (ahajournals.org)
- Incorporate viscoelastic vessel wall models into models of blood flow and pressure in the cardiovascular system and investigate the impact of wall viscoelasticity in blood flow simulations. (simtk.org)
- This project is developing a system for modeling blood flow in arteries incorporating viscoelastic wall models. (simtk.org)
- With this model we try to simulate real life cases and try to obtain results that could bring to better understanding of the circulatory system, while also covering the basis of solid mechanics, fluid mechanics and Partial differential equations solving methods necessary to fully understand the purpose of this project. (upc.edu)
- Similarities in the major organ systems, the vascular system, gastrointestinal tract morphology, as well as similarities in pharmacokinetics make the swine a better model system for studying cardiovascular disease. (mpiresearch.com)
- The model discusses in detail the impact of COVID-19 on Intravascular Ultrasound System (IVUS) Catheters market for the year 2020 and beyond. (yahoo.com)
- This model is required reading for - - CMO executives who must have deep understanding of the Intravascular Ultrasound System (IVUS) Catheters marketplace to make strategic planning and investment decisions. (yahoo.com)
- We provide strong evidence for implication of the redox system in the pathophysiology of the cardiovascular disease in a mouse model of WBS. (biomedsearch.com)
- Palau-Caballero G., Walmsley J., Rudenick P., Evangelista A., Lumens J., Delhaas T. (2015) Hemodynamics in Aortic Regurgitation Simulated Using a Computational Cardiovascular System Model. (springer.com)
- This system is used as a model for the cardiorespiratory interaction in wakefulness and anaesthesia. (lancs.ac.uk)
- We show that long-range correlated noise produces transitions between epochs with different n:m synchronisation ratios, as observed in the cardiovascular system. (lancs.ac.uk)
- Modeling resonance effects of the electromagnetic radiations on the cardiovascular system. (emf-portal.org)
- In the Netherlands, DMPs are often based on the Chronic Care Model (CCM), which clusters six interrelated components of health care systems: health care organization, community linkages, self-management support, delivery system design, decision support, clinical information systems, and last, integration of the first five components. (biomedcentral.com)
- This thesis provides a detailed overview of a system dynamics model that focuses on the accident and emergency department and the clinical pathways of cardiovascular patients at Haukeland University hospital. (uib.no)
- The simulation model illustrates accident and emergency processes and patient attributes in a disaggregated system. (uib.no)
- In addition to System Dynamics, other modeling concepts facilitated the modeling process. (uib.no)
- The use of objects to represent attributes and AED processes make this model a unique take on System Dynamics. (uib.no)
- The four exemplar cases predict varied pathological responses of the cardiovascular system, which are also supported by clinical observations. (gla.ac.uk)
- A model of the arterial system was created using a saphenous vein cardiopulmonary bypass system. (journals.co.za)
- This study presents a minimal cardiovascular system model that includes variations in pulmonary vascular resistance during mechanical ventilation. (canterbury.ac.nz)
- This is a CellML translation of the Guyton model of the regulation of the circulatory system. (cellml.org)
- The other modules characterise the dynamics of the kidney, electrolytes and cell water, thirst and drinking, hormone regulation, autonomic regulation, cardiovascular system etc, and these feedback on the central circulation model. (cellml.org)
- Conclusions There is an excess of models predicting incident CVD in the general population. (bmj.com)
- Conclusions Any intervention that achieved even a modest population-wide reduction in any major cardiovascular risk factor would produce a net cost saving to the NHS, as well as improving health. (bmj.com)
- Conclusions- Magneto-fluorescent nanoparticle CMR permitted effective visualization of myocardial inflammatory cellular infiltrates and distinction of the extent of inflammation compared with conventional CMR in a preclinical model of EAM. (ahajournals.org)
- The team's machine learning model was designed to use all available information, including the patient's coronary artery calcium (CAC) score and non-contrast CT findings, to reach its conclusions. (cardiovascularbusiness.com)
- CONCLUSIONS: Optimal resolution of anatomical details and immediate comprehension of the most important technical aspects were reported by examining the models. (minervamedica.it)
- CONCLUSIONS: Preliminary data suggest that the use of 3D-printed aortic models as a teaching tool was feasible and improved the understanding of aortic disease among surgical trainees. (minervamedica.it)
- Conclusions- Aging and population growth will increase cardiovascular disease by more than a half over the coming 20 years, and projected unfavorable trends in blood pressure, total cholesterol, diabetes, and body mass index may accelerate the epidemic. (scialert.net)
- This paper reviews the methods, benefits and challenges associated with the adoption and translation of computational fluid dynamics (CFD) modelling within cardiovascular medicine. (bmj.com)
- 1 There is increasing interest in applying these methods in cardiovascular medicine. (bmj.com)
- Methods: The proposed method captures spatiotemporal correlation among flow-compensated and flow-encoded image sequences with a novel low-rank model. (harvard.edu)
- METHODS: For each patient, we have 3D printed a preoperative life-sized model of the vascular aortic lumen, deciding and planning the most suitable procedure by its direct examination. (minervamedica.it)
- METHODS: Anonymized CT-angiography images of six different patients were selected as didactic cases of aortic disease and made into 3D models of transparent rigid resin with the Vat-photopolymerization technique. (minervamedica.it)
- Accounting for heterogeneity drives different statistical methods for summarizing data and, if heterogeneity is anticipated, a random-effects model will be preferred to the fixed-effects model. (deepdyve.com)
- Substantial heterogeneity in predictor and outcome definitions was observed between models, and important clinical and methodological information were often missing. (bmj.com)
- When combined with population-scale numerical models, these models have the potential to reduce the cost, time and risk associated with clinical trials. (bmj.com)
- CFD modelling is a new field within cardiovascular medicine, enhancing diagnostic assessment, device design and clinical trials. (bmj.com)
- 4 As CFD modelling continues to translate into clinical tools, it is important that clinicians understand the principles, benefits and limitations of these techniques. (bmj.com)
- Clinical prediction models (CPMs) estimate the probability of clinical outcomes and hold the potential to improve decision making and individualize care. (nih.gov)
- The comparative performance of these models, the consistency of effects and risk estimates across models and the actual and potential clinical impact of this body of literature is poorly understood. (nih.gov)
- Realizing the Potential of Clinical Risk Prediction Models: Where Are We Now and What Needs to Change to Better Personalize Delivery of Care? (nih.gov)
- The general consensus was that the mechanisms behind the association of cardiovascular disease and COPD need to be further investigated at the epidemiological, patho-biological, and clinical levels. (nih.gov)
- We developed, validated and demonstrated highly improved accuracy of two clinical algorithms for global cardiovascular risk prediction that reclassified 40 percent to 50 percent of women at intermediate risk into higher- or lower-risk categories," the authors write. (bio-medicine.org)
- In many other cardiovascular areas, expected outcome benefits of biomarker modulation and even symptomatic clinical modification were not found. (aacrjournals.org)
- Modelling and simulation (M&S) techniques are now commonly used to analyse clinical PKPD data as part of a model-based drug development framework, however, their use in the pre-clinical stages is limited and within the safety sciences is virtually non-existent. (bl.uk)
- Noise and flow artifacts in the medical images and clinical measurements lead to geometric models that contain some uncertainty. (utaustinportugal.org)
- Incorporating these larger animal models earlier into preclinical development plans can contribute to better translation and clinical outcomes. (mpiresearch.com)
- This customized model ultimately provides a wealth of information that helps to understand the individual clinical picture and to run through various therapeutic scenarios. (medica-tradefair.com)
- Our findings suggest that future risk prediction models based on all available information can achieve a more accurate and precise model to identify risk that could be implemented clinically to improve the clinical use of CAC scanning in risk assessment and guiding management decisions," wrote lead author Rine Nakanishi, Toho University Graduate School of Medicine in Tokyo, and colleagues. (cardiovascularbusiness.com)
- Clinical trials generally provide strong evidence of the efficacy of cardiovascular preventive strategies, but poor evidence of their 'real-life' utility, in terms of effectiveness and cost-effectiveness. (ovid.com)
- The Cardiovascular Disease Prevention Model is presented, which represents a means of extrapolating the results of clinical trials to a broader, more relevant context. (ovid.com)
- The Cardiovascular Disease Prevention Model offers a means to translate the results of trials of cardiovascular preventive interventions, in order to inform clinical and public health practice, as well as health policy. (ovid.com)
- Objectives This study sought to develop a model that predicts bleeding complications using an expanded bleeding definition among patients undergoing percutaneous coronary intervention (PCI) in contemporary clinical practice. (onlinejacc.org)
- Risk models that use this expanded definition provide accurate estimates of post-PCI bleeding risk, thereby better informing clinical decision making and facilitating risk-adjusted provider feedback to support quality improvement. (onlinejacc.org)
- To this end, a successful simulation model has been created that permits a detailed observation of clinical pathways for cardiovascular patients. (uib.no)
- The new model can be used to gain insight into cardio-arterial interactions across a range of clinical applications. (gla.ac.uk)
- Absolute risk models or clinical prediction models have been incorporated in guidelines, and are increasingly advocated as tools to assist risk stratification and guide prevention and treatments decisions relating to common health conditions such as cardiovascular disease (CVD) and diabetes mellitus. (elsevier.com)
- The National Heart, Lung, and Blood Institute convened a meeting of investigators on September 21-22, 2006, in Bethesda, Maryland, to evaluate evidence for a pathogenetic link between COPD (Chronic Obstructive Pulmonary Disease) and cardiovascular disease and to recommend future research that may be needed to clarify this relationship and to translate this understanding into better approaches for the prevention and treatment of cardiopulmonary disease. (nih.gov)
Coronary heart disease and2
- Outcome measures Cumulative coronary heart disease and stroke deaths attributed to the different Brexit scenarios modelled between 2021 and 2030. (bmj.com)
- Cardiovascular disease (coronary heart disease and stroke) in adults ages 35 to 84 years was projected from 2010 to 2030 using the Coronary Heart Disease Policy Model-China, a Markov computer simulation model. (scialert.net)
Prediction Models for Cardiovascular Disease1
- Current risk prediction models for cardiovascular disease may be misleading at the individual level because of large variations in practice data, a study has found. (pulsetoday.co.uk)
- Mouse models have proved to be useful to study development and progression of atherosclerotic lesion, and several reviews have extensively discussed the different available models [ 1 - 3 ]. (hindawi.com)
- Eligibility criteria for study selection Studies describing the development or external validation of a multivariable model for predicting CVD risk in the general population. (bmj.com)
- Ideally, a CVD risk score model for patients in Australia should be based upon a large Australian cohort study including information on all relevant risk factors and a sufficient number of CVD outcomes. (mja.com.au)
- Previous chapters have described a large number of transgenic animal models used to study specific cardiovascular syndromes. (springer.com)
- The study involved the application of current CVD risk models to the THIN dataset. (uea.ac.uk)
- These models provide an excellent means to study both acute and chronic responses of RT in the muscles. (medsci.org)
- Study leader Professor Tjeerd van Staa said: 'We looked at a large number of general practices and we say a large variation in the incidence of cardiovascular disease and when we looked further that wasn't taken into account by the QRISK model. (pulsetoday.co.uk)
- Researchers have developed a more accurate way to predict the risk of developing cardiovascular disease among women, according// to a study in the issue of JAMA. (bio-medicine.org)
- The researchers assessed 35 risk factors among 24,558 initially healthy women (free of cardiovascular disease and cancer at the beginning of the study) 45 years or older from the Women's Health Study who were followed up for a median of 10.2 years for incident (new) cardiovascular events, such as myocardial infarction (heart attack), ischemic stroke, coronary revascularization, and cardiovascular deaths. (bio-medicine.org)
- Sawchuk AP, Unthank JL, Davis TE, Dalsing MCA (1994) Prospective, in vivo study of the relationship between blood flow hemodynamics and atherosclerosis in a hyperlipidemic swine model. (springer.com)
- The objective of the present study was to investigate the relationship of the homeostasis model assessment of insulin resistance (HOMA-IR), as well as insulin levels, with risk of nonfatal and fatal CVD over the 8-year follow-up of the San Antonio Heart Study. (diabetesjournals.org)
- Heart Rate Variability, Orthostatic Intolerance, Pulse Wave Velocity, Orthostatic Blood Pressure Responses, accelerometry, cerebral perfusion) which will help provide a better understanding of the mechanisms underlying the association between autonomic function and disease processes and provide an opportunity to study disability associated with global cardiovascular risk. (hrb.ie)
- The cardiovascular experience will therefore not reveal shortcuts to success, but it can suggest how success might be achieved through selection of appropriate high-risk patients, study of sample populations of seemingly daunting size, perhaps with simplified protocols, and carrying out studies long enough to evaluate convincing endpoints. (aacrjournals.org)
- This study establishes and validates a risk model to predict secondary cardiovascular events and cardiovascular death in outpatients with established atherothrombotic disease. (acc.org)
- This is a well-designed contemporary investigator-initiated population study that assessed risk of future cardiovascular events among patients with one or more vascular disease event types. (acc.org)
- It was theorised that more complex models containing the CV feedback mechanisms may be required for some of the unsuccessful predictions.Overall PKPD modelling can be used to describe CV safety pharmacology data in different species and if study design and modelling issues were addressed, greater accuracy could be obtained. (bl.uk)
- The aim of this study was to evaluate the impact of high-dose menaquinone-7 (MK-7) supplementation (100 µg/g diet) on the development of extraosseous calcification in a murine model. (mdpi.com)
- Over the past decade, the zebrafish has become an increasingly popular animal model for the study of human cardiovascular disease. (biologists.org)
- The zebrafish has emerged as an important vertebrate model for the study of cardiovascular disease. (biologists.org)
- This review summarizes the current evidence regarding application and use of biomechanical modeling in the study of stent properties, local flow dynamics, and outcomes after percutaneous coronary interventions in bifurcation lesions. (onlinejacc.org)
- The aim of this study was to assess whether STK25 is also one of the mediators in the complex molecular network controlling the cardiovascular disease risk. (ovid.com)
- This study provides the first evidence that STK25 plays a critical role in regulation of cardiovascular disease risk and suggests that pharmacological inhibition of STK25 function may provide new possibilities for prevention/treatment of atherosclerosis. (ovid.com)
- Thus the current study was performed using an animal model of myocarditis. (sigmaaldrich.com)
- The purpose of this study was to evaluate the effects of avocado oil administration on biochemical markers of cardiovascular risk profile in rats with metabolic changes induced by sucrose ingestion. (nih.gov)
- In the present study we investigated the effects of administration of the plant's leaves extract on some cardiovascular disease (CVD) risk factors in galactose model of experimental cataract. (academicjournals.org)
- Design Economic and epidemiological modelling study with probabilistic sensitivity analysis. (bmj.com)
- In this study, hybrid physiologic-phenomenological models of blood volume and cardiovascular responses to fluid and vasopressor infusion are successfully developed and validated using experimental data. (umd.edu)
- Chen, W.W. , Gao, H. , Luo, X.Y. and Hill, N.A. (2016) Study of cardiovascular function using a coupled left ventricle and systemic circulation model. (gla.ac.uk)
- First steps towards modelling myocardial infarction (a computed MI Physiome): A case-control study of novel biomechanical parameters in acute MI survivors with left ventricular dysfunction. (gla.ac.uk)
- In this study, we intend to assess the relationship between CDs and radiation exposure by animal model studies and to obtain information about biological mechanisms. (nii.ac.jp)
- In epidemiological studies different types of models are used to estimate exposure of study participants. (trb.org)
- Furthermore a comparison of dispersion modeling (DM) and land use regression (LUR) was done in several study areas and a hybrid model based on DM and LUR was developed for Stockholm. (trb.org)
- In particular, knockout and transgenic mouse models for atherosclerosis have been instrumental in understanding the molecular and cellular mechanisms involved in atherogenesis, and in evaluating the effectiveness of new and existing atherosclerotic drugs [ 4 ]. (hindawi.com)
- As wild-type mice are resistant to lesion development, the current mouse models for atherosclerosis are based on genetic modifications of lipoprotein metabolism with additional dietary changes. (hindawi.com)
- Our mouse model repository maintains hundreds of mouse models to accelerate research in coronary heart disease (including, atherosclerosis, ischemic/reperfusion injury and myocardial infarction), hypertension, hypertrophy and heart failure, and other heart abnormalities. (jax.org)
- Seli E, Guzeloglu-Kayisli O, Kayisli UA, Kizilay G, Arici A. Estrogen increases apoptosis in the arterial wall in a murine atherosclerosis model. (springer.com)
- the total arterial compliance, which is considered to be a cardiovascular risk factor, indicating the development of hypertension and atherosclerosis. (simula.no)
- Reardon CA, Getz GS (2001) Mouse models of atherosclerosis. (springer.com)
- We anticipate our work to be a starting point for a more sophisticated multi-scale model, which combines experimental findings and computational modelling to characterize arterial segments affected by atherosclerosis. (omicsonline.org)
- However, porcine models of atherosclerosis/ischemia or ischemia reperfusion allow examination of interventions on neovascularisation, functional recovery, biomarker changes, vascular remodeling, and infarct size, providing insight into the therapeutic potential of the therapy. (mpiresearch.com)
- Recent cohort studies have shown that nonalcoholic fatty liver disease (NAFLD), and especially nonalcoholic steatohepatitis (NASH), associate with atherosclerosis and cardiovascular disease, independently of conventional cardiometabolic risk factors. (ovid.com)
- High resolution model created in 3ds max 2014 rendered with vray materials and particle flow simulation of the blood cells. (turbosquid.com)
- A sex- and age-group specific epidemiological macro-simulation model was used to estimate the preventable deaths due to the differences between country specific actual intake and recommended intake of changes in food components. (mdpi.com)
- DESIGN: A cohort simulation model developed as part of the economic evaluation conducted alongside the Healthlines randomised controlled trial. (whiterose.ac.uk)
- The UK government strategy for the primary prevention of cardiovascular disease therefore focuses on a dual approach. (bmj.com)
- The effectiveness and cost effectiveness of population based dietary approaches to prevention of cardiovascular disease in the UK are less clear. (bmj.com)
- As 8 to 10 million U.S. women have an ATP-III estimated 10-year risk between 5 percent and 20 percent, application of these data could have an immediate effect on cardiovascular prevention," the authors conclude. (bio-medicine.org)
- Despite the strong history of cardiovascular health research in Ireland and policy implementation, the area of policy and implementation especially in secondary prevention and health promotion i.e. the structured and efficient translation of research evidence into policy and practice remains an under-researched field. (hrb.ie)
- To estimate the effects of achieving China's national goals for dietary salt (NaCl) reduction or implementing culturally-tailored dietary salt restriction strategies on cardiovascular disease (CVD) prevention. (columbia.edu)
- This lumped pulsatile cardiovascular model consists of eight compartments of the body that include pumping heart, the systemic circulation, and the pulmonary circulation. (koreascience.or.kr)
- We extend the developed lumped model of circulation in normal case into a specific model for arrhythmia. (koreascience.or.kr)
- A systems analysis diagram for the full Guyton model describing circulation regulation. (cellml.org)
- Derived from workspace Guyton, Full cardiovascular circulation model at changeset 289ac0cbccb2 . (cellml.org)
- Medical models of cardiovascular stent inside blood vessel. (turbosquid.com)
- Habashi JP, Judge DP, Holm TM et al (2006) Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome. (springer.com)
- Feintuch A, Ruengsakulrach P, Lin A et al (2007) Hemodynamics in the mouse aortic arch as assessed by MRI, ultrasound and numerical modeling. (springer.com)
- MK-7 supplementation inhibited cardiovascular calcification and decreased aortic alkaline phosphatase tissue concentrations. (mdpi.com)
- The 3D aortic models, which could be disassembled and reassembled, were displayed to 37 surgical trainees, immediately after a seminar on aortic disease. (minervamedica.it)
- The coupling of the LV model and the SA model is achieved by matching the pressure and the flow rate at the aortic root, i.e. the SA model feeds back the pressure as a boundary condition to the LV model, and the aortic flow rate from the LV model is used as the input for the SA model. (gla.ac.uk)
- Accuracy of cardiovascular magnetic resonance in myocarditis: comparison of MR and histological findings in an animal model. (sigmaaldrich.com)
- Because endomyocardial biopsy has low sensitivity of about 20%, it can be performed near to myocardium that presented as late gadolinium enhancement (LGE) in cardiovascular magnetic resonance (CMR). (sigmaaldrich.com)
- Journal of Cardiovascular Magnetic Resonance 19 (1): 19. (harvard.edu)
- Background: Conventional phase-contrast cardiovascular magnetic resonance (PC-CMR) employs cine-based acquisitions to assess blood flow condition, in which electro-cardiogram (ECG) gating and respiration control are generally required. (harvard.edu)
- Our recent work found an increase in the relative incidence of cardiovascular outcomes during the ∼ 30 days after infection-related hospitalizations using the case series model, which adjusts for measured and unmeasured baseline confounders. (repec.org)
- What is the value of a biomarker panel for predicting cardiovascular (CV) outcomes following non-ST-segment elevation acute coronary syndrome (NSTE-ACS)? (acc.org)
- Ultimately, the effect of introducing validated models in routine practice on the process and outcomes of care as well as its cost-effectiveness should be tested in impact studies before wide dissemination of models beyond the research context. (elsevier.com)
- The application of risk adjustment methodology to account for patient differences in these treatment outcomes is imperative for legitimate comparison of institutional results in the modern era of cardiovascular intervention. (onlinejacc.org)
- Model integration is progressively moving towards 'digital patient' or 'virtual physiological human' representations. (bmj.com)
- Human PK and baseline were fixed, pharmacological values were set as the animal values and physiological values were scaled according to body weight using an exponent of -0.25.Adequate fits to PK, baseline and PD data were generally observed, although issues with sampling times and dose ranges restricted the model options in a number of cases. (bl.uk)
- If greater model complexity is restricted to physiological aspects the use of such models in safety pharmacology may also help to give more insight into mechanism of action. (bl.uk)
- Thus, it is worth developing model-based automated systems relating the fluid and vasopressor dose input to the underlying physiological states. (umd.edu)
- However, most of existing models are too simplistic to reflect physiological reality, while others are too complicated with thousands of parameters to tune. (umd.edu)
- It is shown that the models can adequately reproduce the underlying physiological states and endpoints to fluid and vasopressor infusion. (umd.edu)
- A baseline case using physiological measurements of healthy subjects, and four exemplar cases based on different physiological and pathological scenarios are studied using the LV-SA model. (gla.ac.uk)
- The complete model consists of separate modules each of which characterise a separate physiological subsystems. (cellml.org)
Computational fluid dy1
- In our studies, image-based computational fluid dynamics (CFD) models are used to determine hemodynamic variables related to vascular disease progression and predict flow changes that would result form alternative treatment options. (purdue.edu)
Death from cardiovascular disease1
- Lipid abnormalities are major risk factors of death from cardiovascular disease (CVD). (magiran.com)
- Almost one-third of all deaths in the Australian population in 2011 were attributable to cardiovascular disease (CVD), 1 and around 80% of these were preventable. (mja.com.au)
- A developmental prediction model was estimated from 33,419 randomly selected participants (2,394 cardiovascular events with 1,029 cardiovascular deaths) from the pool of 49,689. (acc.org)
- The prediction model was validated in the remaining 16,270 REACH subjects (1,172 cardiovascular events, 494 cardiovascular deaths). (acc.org)
- Overall, the team found that its AI model achieved an area under the curve for predicting CVD deaths (0.845) higher than two other traditional risk scores, the ASCVD risk calculator (0.821) and the CAC score alone (0.781). (cardiovascularbusiness.com)
- Objectives To estimate the potential impacts of different Brexit trade policy scenarios on the price and intake of fruits and vegetables (F&V) and consequent cardiovascular disease (CVD) deaths in England between 2021 and 2030. (bmj.com)
- Projected trends in blood pressure, total cholesterol, diabetes (increases), and active smoking (decline) would increase annual cardiovascular disease events by an additional 23%, an increase of approximately 21.3 million cardiovascular events and 7.7 million cardiovascular deaths over 2010 to 2030. (scialert.net)
- Aggressively reducing active smoking in Chinese men to 20% prevalence in 2020 and 10% prevalence in 2030 or reducing mean systolic blood pressure by 3.8 mm Hg in men and women would counteract adverse trends in other risk factors by preventing cardiovascular events and 2.9 to 5.7 million total deaths over 2 decades. (scialert.net)
- Utilizing genomic approaches to interrogate mechanisms of inherited cardiovascular disorders. (jax.org)
- Studies are needed to assess the common mechanisms by which immune responses and inflammation may contribute to cardiovascular disease and COPD. (nih.gov)
- Cardiovascular disease remains the leading cause of death in the United States and worldwide, indicating the continued need for basic science research into disease mechanisms and the development of therapeutics. (heart.org)
- 1 Cardiovascular disease modeling using iPSCs has thus shed light on a multitude of disease mechanisms, and provided readily translatable insights into therapeutic resolution to disease progression. (heart.org)
- Dog showed the best potential for prediction of CV measures and predictions might be improved with the use of CV models that incorporate accurate feedback mechanisms. (bl.uk)
- Classically, pharma, biotech, and device researchers have relied on rodent models to discover and validate disease targets and mechanisms, as well as for the preclinical development of therapeutics. (mpiresearch.com)
- Thank you for your interest in spreading the word on Disease Models & Mechanisms. (biologists.org)
- Message Body (Your Name) thought you would like to see the Disease Models & Mechanisms web site. (biologists.org)
- However, the mechanisms underlying the pathophysiological link between NAFLD/NASH and cardiovascular disease still remain unclear. (ovid.com)
Treatment of cardiovascular disease1
- The mission of the Cardiovascular Flow Modeling Laboratory (CFM Lab) is to improve diagnostics and treatment of cardiovascular disease by conducting engineering analysis of blood flow dynamics. (purdue.edu)
- The derived models must then be tested both on the development sample (internal validation) and on other populations in different settings (external validation). (elsevier.com)
- The color-coded and fully-sourced models are equipped with epidemiology based indications with procedure volumes.To increase the data transparency, the interactive excel deliverable covers installed base, new sales volumes, product usage, average selling prices, market size and company share analysis. (reportlinker.com)
- The European CVD epidemiology models are likely to have significant impact on the public understanding of CVD, which can be used together with each countries own initiative and strategies for preventing this largely preventable disease. (europa.eu)
- The courses covered key themes including: (i) an introduction to CVD epidemiology, (ii) an introduction to models for CVD in Europe and elsewhere and (iii) practical sessions on these models. (europa.eu)
- All course materials were provided to attendees including information on the epidemiology of CVD, the various epidemiology models described and data sources. (europa.eu)
- The attendees demonstrated a good understanding of CVD epidemiology and the strengths and limitations of relevant policy models. (europa.eu)
- Each of the covered 39 countrys color-coded and fully-sourced market models are equipped with epidemiology based indications with procedure volumes. (aarkstore.com)
- An absolute risk approach to managing cardiovascular disease (CVD) risk factors is superior to managing individual risk factors, and has been endorsed by peak professional bodies and in CVD management guidelines. (mja.com.au)
- Many of the risk factors predisposing people to CVD are known, and there are a number of survival models to identify those who could benefit from preventive treatment. (uea.ac.uk)
- Paul M Ridker, M.D., M.P.H., from Brigham and Women's Hospital, Boston, and colleagues, developed and validated cardiovascular risk algorithms for women based on a large set of traditional and new risk factors. (bio-medicine.org)
- To develop the model, which will be available later this year at www.globorisk.org, the researchers analyzed data from more than 50,000 participants in eight existing long-term studies, which included risk factors such as blood pressure, cholesterol , diabetes , and smoking , as well as gender and age. (harvard.edu)
- To measure changes in cardiovascular risk factors among patients with coronary heart disease (CHD) and/or type 2 diabetes enrolled in a centralised statewide coaching program delivered by telephone and mail-out in the public health sector in Queensland. (mja.com.au)
- Similar differences were found in mean change scores in cardiovascular risk factors between Indigenous and non-Indigenous Queenslanders. (mja.com.au)
- 15 Aboriginal and Torres Strait Islander Australians face an even greater burden of disease because of their increased predisposition for acquiring diabetes (up to 10-fold higher prevalence) 16 , 17 and associated cardiovascular risk factors throughout life and at an earlier age than the non-Indigenous population. (mja.com.au)
- Risk of cardiovascular death was similarly estimated with the same set of risk factors. (acc.org)
- National policy aimed at controlling blood pressure, smoking, and other risk factors would counteract the expected future cardiovascular disease epidemic in China. (scialert.net)
- However, genetic and environmental factors play a significant role in cardiovascular pathophysiology, making difficult to match a particular disease, with a single experimental model. (hindawi.com)
- Experimental models that try to mimic these adaptations in rats, use a model of chronic muscle stretching, compensatory overload and electric stimulation in unconscious animals. (medsci.org)
- The results suggest that the estimate of the relative incidence of cardiovascular events during the 30 days after infections, a period where acute effects of infection on vascular endothelium may be most pronounced, is substantially attenuated in the presence of infection onset measurement error. (repec.org)
- We examined in detail the accuracy of the proposed method to estimate the relative incidence of cardiovascular events. (repec.org)
- Analyses of existing data and new population-based epidemiological data are needed to clarify the relationship between cardiovascular disease and COPD, including the cardiovascular association with pulmonary function measures (e.g. (nih.gov)
- This work may help us untangle the role of cardiovascular disease across all autonomic function measures in future disability, thus providing an opportunity for more healthy-life years in the ageing population. (hrb.ie)
- After the intervention, we have examined the corresponding model printed derived from postoperative CTA to check the outcome and discuss possible further corrections, if needed. (minervamedica.it)
- The aim of this project is to develop PKPD models using safety pharmacology data, which can be used to predict cardiovascular (CV) effects in man.Non-linear mixed effects modelling was used to analyse the PKPD relationships for the haemodynamic effects of NG-nitro-L-arginine methyl ester (L-NAME), milrinone and doxazosin in three species (rat, dog and guinea-pig). (bl.uk)
Visualize quantitative market trends2
- Vascular Grafts - Cardiovascular Market Analysis and Forecast Model is built to better visualize quantitative market trends of Vascular Grafts within the Cardiovascular Devices market. (reportlinker.com)
- Summary Beating Heart Surgery Systems (Cardiovascular) - Global Market Analysis and Forecast Model (COVID-19 market impact) is built to visualize quantitative market trends within Cardiovascular Devices therapeutic area. (yahoo.com)
- This database contains CPMs for 31 index conditions, including 215 CPMs for patients with coronary artery disease, 168 CPMs for population samples, and 79 models for patients with heart failure. (nih.gov)
- In particular, porcine models have been particularly valuable in assessing myocardial infarction and congestive heart failure, as they reflect the human disease state and can be modified to address different research goals. (mpiresearch.com)
- MPI Research has established swine models of myocardial infarction and congestive heart failure, and has used these models to cost-effectively and quickly assess modalities from small-molecule therapeutics to biologics, devices, and stem cell regenerative therapies. (mpiresearch.com)
- Ecole Polytechnique Federale de Lausanne, School of Engineering, Interfaculty Institute of Bioengineering, Laboratory of Hemodynamics and Cardiovascular Technology, Switzerland. (nih.gov)
- The facile and inexpensive clustered regularly interspaced short palindromic repeats (CRISPR) method has now superseded traditional means of genome modification such that virtually any laboratory can quickly assemble reagents for developing new mouse models for cardiovascular research. (ahajournals.org)
Patients with cardiovascular1
- For patients with cardiovascular disease, there are numerous CPMs available although the extent of this literature is not well described. (nih.gov)
- The approach is exemplified for two clinically relevant models, predicting the following: i.) the severity of coronary artery stenosis, which is a predisposition to stroke and transient ischaemic attack, and ii. (simula.no)
- RESULTS -Over the follow-up period, 187 subjects experienced an incident cardiovascular event (heart attack, stroke, heart surgery, angina, or CVD death). (diabetesjournals.org)
- and Council on Cardiovascular and Stroke Nursing. (heart.org)
- From a public health point of view cardiovascular effects of long-term exposure are predominant, primarily coronary events and stroke. (trb.org)
- While the main focus of our studies is on numerical simulations of the flow in cerebral aneurysms, we are also involved in modeling blood flow in other vascular territories as well as in design and optimization of biomedical devices, such as a Chemofilter device removing chemotherapy drugs from blood. (purdue.edu)
- iPSC technology is a valuable platform for modeling cardiovascular disease because the cellular source is human in origin, often reprogrammed directly from the somatic cells of an affected individual, the cells can be differentiated into any somatic cell type following reprogramming, meaning cardiomyocytes, vascular smooth muscle cells, and endothelial cells can each be investigated, and the cellular population can self-renew, allowing for an essentially endless supply of cells. (heart.org)
- As new biomarkers are better characterized and assays are improved, it seems likely that multiple biomarkers reflecting distinct vascular processes may provide a more comprehensive and accurate prediction of both short- and long-term cardiovascular risk. (acc.org)
- In the current literature, models of blood flow applied to the characterization of atherosclerotic plaques consider blood as a Newtonian fluid because of the characteristic length of the domain . (omicsonline.org)
- Such model includes a coupling between the distending arterial wall and the non-Newtonian blood flow. (omicsonline.org)
- Currently the implementation is a one-dimensional model of blood flow and pressure incorporating a linear viscoelastic wall model. (simtk.org)
- Viscoelasticity of the wall is also being implemented in a 3-D FSI computational model of blood flow through the SimVascular project. (simtk.org)
Field of cardiovascular2
- nicely present an overview of induced pluripotent stem cell (iPSC) technology and its current and future application to the field of cardiovascular medicine. (heart.org)
- To date, most in vitro and in vivo studies in the field of cardiovascular tissue research rely on the conventional monolayer (2D) cell cultures. (frontiersin.org)
Development of cardiovascular1
- Our results show that high-dose MK-7 supplementation inhibits the development of cardiovascular calcification. (mdpi.com)
- Rather than developing yet another similar CVD risk prediction model, in this era of large datasets, future research should focus on externally validating and comparing head-to-head promising CVD risk models that already exist, on tailoring or even combining these models to local settings, and investigating whether these models can be extended by addition of new predictors. (bmj.com)
- Over the past two decades, numerous prediction models have been developed, which mathematically combine multiple predictors to estimate the risk of developing CVD-for example, the Framingham, 3 4 5 SCORE, 6 and QRISK 7 8 9 models. (bmj.com)
- Although there is a large literature on measurement error in the predictors in regression modeling, to date, there is no work on measurement error on the timing of a time-varying exposure to our knowledge. (repec.org)
- HDL-cholesterol concentration in blood is inversely associated with risk of coronary heart disease and remains one of the strongest independent predictors of incident cardiovascular events. (onlinejacc.org)
- Multilevel regression models were performed to reveal predictors of high CCM compliance. (biomedcentral.com)
- A one-dimensional (1-D) cardiovascular tree model was constructed including a simplified SC arterial network. (nih.gov)
- Moreover, we demonstrated how UQ and SA can be applied to guide the selection of the most suitable models, exemplified with the choice of arterial wall models when simulating one-dimensional arterial networks. (simula.no)
- To gain insight into cardio-arterial interactions, a coupled left ventricle-systemic artery (LV-SA) model is developed that incorporates a three-dimensional finite-strain left ventricle (LV), and a physiologically-based one-dimensional model for the systemic arteries (SA). (gla.ac.uk)
- We will conduct several animal studies, to continue work on our general hypothesis that pre-existing inflammation and old age are important priming factors to sensitize the host for subsequent pulmonary and cardiovascular effects of inhaled ultrafine particles. (epa.gov)
- Pereira GC, Zoltan K (2016) A Multi-Layer Non-Newtonian Model of Cardiovascular Inflammation. (omicsonline.org)
- On July 25, 2016, the U.S. Department of Health & Human Services (DHHS) proposed a new bundling model as part of its mission to shift Medicare payments from quantity to quality. (scct.org)
- SCCT's Advocacy Committee (consisting of several dedicated volunteers and expert staff) is preparing comments to DHHS on this proposed bundling model by the due date of September 26, 2016. (scct.org)
- The new algorithms are called the Reynolds Risk Score and the clinically simplified model for non-diab etic women includes age, systolic blood pressure, current smoking, total and HDL cholesterol, high sensitivity C-reactive protein (CRP) and parental history of myocardial infarction before age 60. (bio-medicine.org)
- Human induced pluripotent stem cells (hiPSCs) hold promise for myocardial repair following injury, but preclinical studies in large animal models are required to determine optimal cell preparation and delivery strategies to maximize functional benefits and to evaluate safety. (biomedsearch.com)
- Here, we utilized a porcine model of acute myocardial infarction (MI) to investigate the functional impact of intramyocardial transplantation of hiPSC-derived cardiomyocytes, endothelial cells, and smooth muscle cells, in combination with a 3D fibrin patch loaded with insulin growth factor (IGF)-encapsulated microspheres. (biomedsearch.com)
- Model discrimination and calibration were assessed in the overall population and among the following pre-specified patient subgroups: females, those older than 70 years of age, those with diabetes mellitus, those with ST-segment elevation myocardial infarction, and those who did not undergo in-hospital coronary artery bypass grafting. (onlinejacc.org)
- Separate models were developed for presentation with and without acute myocardial infarction (MI) within 24 h. (onlinejacc.org)
- The model predicts that Iceland would benefit the most by adhering to the NNR, followed by Finland. (mdpi.com)
- I have built a 3-D theoretical model that predicts the inducibility of VT based on physical properties of the reentry circuits (i.e. geometry of the scars, tissue electrical conductivity and fibre directions). (sunnybrook.ca)
- A multimarker model consisting of TnT, IL-10, MP, and PlGF predicted 4-year event rates that varied between 6.0% (all markers normal) and 35.8% (three or more biomarkers abnormal). (acc.org)