Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Depressive states usually of moderate intensity in contrast with major depression present in neurotic and psychotic disorders.
Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems.
Marked depression appearing in the involution period and characterized by hallucinations, delusions, paranoia, and agitation.
An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent.
The unsuccessful attempt to kill oneself.
The act of killing oneself.
A publication issued at stated, more or less regular, intervals.
The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)
Individual's rights to obtain and use information collected or generated by others.
A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
The evaluation by experts of the quality and pertinence of research or research proposals of other experts in the same field. Peer review is used by editors in deciding which submissions warrant publication, by granting agencies to determine which proposals should be funded, and by academic institutions in tenure decisions.
The collection, writing, and editing of current interest material on topics related to biomedicine for presentation through the mass media, including newspapers, magazines, radio, or television, usually for a public audience such as health care consumers.
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
The process of cumulative change over successive generations through which organisms acquire their distinguishing morphological and physiological characteristics.
Principles, models, and laws that apply to complex interrelationships and interdependencies of sets of linked components which form a functioning whole, a system. Any system may be composed of components which are systems in their own right (sub-systems), such as several organs within an individual organism.
Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
A subnormal level of BLOOD PLATELETS.
ANIMALS whose GENOME has been altered by GENETIC ENGINEERING, or their offspring.
Exclusive legal rights or privileges applied to inventions, plants, etc.
The number of PLATELETS per unit volume in a sample of venous BLOOD.
A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
A group of disorders characterized by physiological and psychological disturbances in appetite or food intake.
A plant species of the family POACEAE that is widely cultivated for its edible seeds.
A branch of embryology for the study of congenital malformations and developmental abnormalities.
An eating disorder that is characterized by a cycle of binge eating (BULIMIA or bingeing) followed by inappropriate acts (purging) to avert weight gain. Purging methods often include self-induced VOMITING, use of LAXATIVES or DIURETICS, excessive exercise, and FASTING.
A disorder associated with three or more of the following: eating until feeling uncomfortably full; eating large amounts of food when not physically hungry; eating much more rapidly than normal; eating alone due to embarrassment; feeling of disgust, DEPRESSION, or guilt after overeating. Criteria includes occurrence on average, at least 2 days a week for 6 months. The binge eating is not associated with the regular use of inappropriate compensatory behavior (i.e. purging, excessive exercise, etc.) and does not co-occur exclusively with BULIMIA NERVOSA or ANOREXIA NERVOSA. (From DSM-IV, 1994)
An eating disorder that is characterized by the lack or loss of APPETITE, known as ANOREXIA. Other features include excess fear of becoming OVERWEIGHT; BODY IMAGE disturbance; significant WEIGHT LOSS; refusal to maintain minimal normal weight; and AMENORRHEA. This disorder occurs most frequently in adolescent females. (APA, Thesaurus of Psychological Index Terms, 1994)
Eating an excess amount of food in a short period of time, as seen in the disorder of BULIMIA NERVOSA. It is caused by an abnormal craving for food, or insatiable hunger also known as "ox hunger".
Research carried out by nurses in the clinical setting and designed to provide information that will help improve patient care. Other professional staff may also participate in the research.
The use of animals as investigational subjects.
The observable response an animal makes to any situation.
The protection of animals in laboratories or other specific environments by promoting their health through better nutrition, housing, and care.
The moral and ethical bases of the protection of animals from cruelty and abuse. The rights are extended to domestic animals, laboratory animals, and wild animals.
Institutional committees established to protect the welfare of animals used in research and education. The 1971 NIH Guide for the Care and Use of Laboratory Animals introduced the policy that institutions using warm-blooded animals in projects supported by NIH grants either be accredited by a recognized professional laboratory animal accrediting body or establish its own committee to evaluate animal care; the Public Health Service adopted a policy in 1979 requiring such committees; and the 1985 amendments to the Animal Welfare Act mandate review and approval of federally funded research with animals by a formally designated Institutional Animal Care and Use Committee (IACUC).
A sulfonic acid-based naphthylazo dye used as a coloring agent for foodstuffs and medicines and as a dye and chemical indicator. It was banned by the FDA in 1976 for use in foods, drugs, and cosmetics. (From Merck Index, 11th ed)
A surgical specialty concerned with the study, diagnosis, and treatment of diseases of the urinary tract in both sexes, and the genital tract in the male. Common urological problems include urinary obstruction, URINARY INCONTINENCE, infections, and UROGENITAL NEOPLASMS.
Electrophoresis in which a pH gradient is established in a gel medium and proteins migrate until they reach the site (or focus) at which the pH is equal to their isoelectric point.
Time period from 1901 through 2000 of the common era.
Time period from 2001 through 2100 of the common era.
A vertical distance measured from a known level on the surface of a planet or other celestial body.
A plant genus of the family VIOLACEAE. Some species in this genus are called bouncing bet which is a common name more often used with SAPONARIA OFFICINALIS. Members contain macrocyclic peptides.
A genus of silkworm MOTHS in the family Bombycidae of the order LEPIDOPTERA. The family contains a single species, Bombyx mori from the Greek for silkworm + mulberry tree (on which it feeds). A native of Asia, it is sometimes reared in this country. It has long been raised for its SILK and after centuries of domestication it probably does not exist in nature. It is used extensively in experimental GENETICS. (From Borror et al., An Introduction to the Study of Insects, 4th ed, p519)
A malignant neoplasm of the ADRENAL CORTEX. Adrenocortical carcinomas are unencapsulated anaplastic (ANAPLASIA) masses sometimes exceeding 20 cm or 200 g. They are more likely to be functional than nonfunctional, and produce ADRENAL CORTEX HORMONES that may result in hypercortisolism (CUSHING SYNDROME); HYPERALDOSTERONISM; and/or VIRILISM.
A condition characterized by mucosal tears at the ESOPHAGOGASTRIC JUNCTION, sometimes with HEMATEMESIS. Typically it is caused by forceful bouts of retching or VOMITING.
Structures within the CELL NUCLEUS of insect cells containing DNA.

Efficacy of herpes simplex virus thymidine kinase in combination with cytokine gene therapy in an experimental metastatic breast cancer model. (1/9364)

Immunotherapy in combination with suicide gene therapy for breast cancer was tested using a metastatic animal model. Subcutaneous injection of the nonimmunogenic breast cancer cell line 4T1 in BALB/C mice gave rise to tumors in 100% of mice with both micrometastases and macrometastases in the lung. We used the herpes simplex virus thymidine kinase (HSV-TK) gene along with the cytokine genes granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-2 (IL-2) to determine their effect on tumor regression and inhibition of lung metastasis. Adenoviral (AV) vectors carrying these transgenes, in separate constructs, were used in this study. Intratumoral administration of AV-TK followed by 10 days of ganciclovir treatment resulted in a delay in tumor growth and, in some cases, in a low to moderate reduction in tumor volume. Inclusion of either GM-CSF or IL-2 gene with HSV-TK resulted in a slightly greater reduction in tumor volume, although these data were not significantly different from those obtained for TK treatment alone. However, when both cytokine genes were combined with TK, a substantial reduction in tumor growth was observed compared with HSV-TK alone (P < .02). Tumor weight data also exhibited superior efficacy of TK/GM-CSF/IL-2 treatment when compared with animals treated with TK gene only (P < .01). More importantly, TK/GM-CSF/IL-2 combination gene therapy induced a significant reduction in lung metastasis compared with any other treatment groups in the 4T1 model (P < .001 between TK GM-CSF/IL-2 versus TK only). Surgical excision of primary tumors after TK/GM-CSF/IL-2 plus ganciclovir treatment resulted in anti-metastatic activity that was similar to that observed for animals in which no surgery was performed. Survival analysis showed a significant difference between animals treated with AV-TK/GM-CSF/IL-2 and animals treated with TK only at 35 days after virus injection (P < .01). Immunophenotypic data suggest infiltration of lymphocytes within the tumor microenvironment in TK- and cytokine gene-treated animals. Thus, the overall data presented here demonstrate that TK gene therapy in combination with GM-CSF and IL-2 gene-mediated immunotherapy strategies have important implications in the treatment of breast cancer.  (+info)

Primary cultured hepatocytes of the bony fish, Oreochromis mossambicus, the tilapia: a valid tool for physiological studies on IGF-I expression in liver. (2/9364)

In spite of the importance of IGF-I for growth and development, knowledge about regulation of its production in submammalian species is rather limited. In order to create a tool for investigation of direct regulatory effects on the expression of IGF-I in bony fish liver, a primary cell culture of hepatocytes from Oreochromis mossambicus, the tilapia, was established. The cells were viable for up to 3 days and IGF-I mRNA synthesis was detected by northern blot and semiquantitative reverse transcriptase (RT)-PCR. Northern blot analysis of the primary cultured hepatocytes revealed four different IGF-I transcripts, 0.5, 1.9, 3.9 and 6.0 kb in size, which were identical to those in liver tissue. However, the expression rate was weaker than that in liver. The direct effects of recombinant tilapia (rt) growth hormone (GH) and salmon (s) IGF-I on the expression of IGF-I in primary cultured hepatocytes were investigated in time-course and dose-response experiments. In untreated cultures, IGF-I mRNA decreased with time. Hepatocytes treated with 100 nM rtGH resulted in a pronounced stimulation of IGF-I mRNA expression throughout the experiment. Treatment with rtGH in concentrations ranging from 0.1 nM to 1 microM caused a clear dose-dependent increase in the amount of IGF-I mRNA. Significant stimulation was obtained even with 0.1 nM, reaching a plateau with 10 nM. Neither significant inhibitory nor stimulatory effects were detected by adding sIGF-I from 0.1 nM to 1 microM to the hepataocytes. Our results indicate that the established primary cell culture of tilapia hepatocytes is a useful system in which to study direct effects of potential regulators of bony fish liver cell function.  (+info)

Exclusive androgenic effect of dehydroepiandrosterone in sebaceous glands of rat skin. (3/9364)

In order to analyze the hormonal effects of dehydroepiandrosterone (DHEA) in skin sebaceous glands, the precursor steroid was administered to ovariectomized (OVX) female Sprague-Dawley rats at a dose of 30 mg applied on the dorsal skin, twice daily, for 3, 6 and 12 months. In a parallel experiment, female OVX rats were treated with DHEA at the same daily percutaneous dose of 30 mg, alone or in combination with the antiandrogen Flutamide or the pure antiestrogen EM-800, for 12 months, in order to determine the androgenic and/or estrogenic components of DHEA action. Treatment of female OVX rats with DHEA resulted in a similar mild to moderate hyperplasia of the sebaceous glands of both dorsal (site of application) and ventral skin, as illustrated by an increase in the number and size of the acini. The above-indicated effects were observed at all time intervals studied, beginning at 3 months of treatment, and they were not further increased after longer term administration of DHEA (for 6 and 12 months). The addition of Flutamide to DHEA treatment completely prevented the DHEA-induced changes in the sebaceous glands, whereas the antiestrogen EM-800 had no effect. The present data indicate an exclusive androgenic stimulatory action of DHEA on the sebaceous glands, thus pointing out the importance of local intracrine DHEA transformation into androgens for skin anatomical integrity and function, while showing that estrogens, if active in rat skin, do not originate from DHEA.  (+info)

Electrophysiological and cardiohemodynamic effects of AH-1058, a new type calcium channel blocker, assessed by the in vivo canine model. (4/9364)

AH-1058 (4-(5H-dibenzo[a, d]cyclohepten-5-ylidene)- 1-[(E)-3-(3-methoxy-2-nitro)phenyl-2-propenyl]piperidine hydrochloride) is a novel calcium channel blocker whose chemical structure is quite different from those of typical calcium channel blockers. In this study, electrophysiological and hemodynamic effects of AH-1058 were assessed in the halothane-anesthetized, closed-chest canine model. Intravenous administration of a canine antiarrhythmic dose of 100 microg/kg of AH-1058 (n = 6) did not affect the cardiovascular variables, except that the cardiac output was decreased at 30 min after the drug administration. Additional administration of 200 microg/kg of AH-1058 (n = 6) suppressed the sinus nodal automaticity, AV nodal conduction and ventricular contraction and decreased the mean blood pressure, cardiac output and double product. The effects gradually appeared, while no change was detected in the intraventricular conduction, ventricular repolarization period, ventricular effective refractory period, preload to the left ventricle and total peripheral vascular resistance during the observation period of 30 min. The cardiosuppressive effects of AH-1058 can be explained by its calcium channel blocking action demonstrated in a previous in vitro experiment, while the lack of the effect on the vascular resistance would suggest that AH-1058 may become a slow-acting cardioselective calcium channel blocker.  (+info)

The effect of the prostaglandin I2 analogue OP-2507 on adrenaline-induced pulmonary edema in rabbits and analysis of hemodynamic changes. (5/9364)

This study was carried out to understand the onset mechanism of adrenaline (ADR)-induced pulmonary edema (PE) and the effect of drugs related to the arachidonate cascade in a rabbit model. ADR was administered intravenously by a bolus injection to the rabbits at 50, 75 and 100 microg/kg. To evaluate the severity of PE, the lung-water ratio (LWR) was calculated as a ratio of the difference between wet and dry lung weight to dry lung weight. The PE incidence and LWR exhibited a dose-dependent increase, and LWR correlated with the left atrial pressure (LAP). The involvement of the arachidonate cascade was evaluated by the co-administration of flurbiprofen, a cyclooxygenase inhibitor; ozagrel, a thromboxane synthase inhibitor; and OP-2507 (15-cis-(4-n-propylcyclohexyl)-6,17,18, 19,20-pentanor-9-deoxy-6,9-alpha-nitriloprostaglandin F1 methyl ester), a prostaglandin I2 analogue. Co-treatment of the rabbits with ADR and flurbiprofen resulted in an increase in LAP and the incidence of PE, whereas co-administration of ozagrel did not exhibit any significant changes in the measured parameters. Conversely, OP-2507 reduced the LAP, PE incidence and LWR when co-administered with ADR. Rabbits co-treated with OP-2507 displayed an improved cardiac function. The results of these studies demonstrated the effectiveness of OP-2507 in protecting the lung and cardiac function from the ADR-induced PE.  (+info)

Standardized ejection fraction as a parameter of overall ventricular pump function. (6/9364)

To evaluate the pump function of the ventricle, a parameter which (i) incorporates systolic and diastolic function and (ii) separates the heart from preload and afterload is needed. This study utilized ejection fraction (EF), calculated from the end-systolic (ES) and end-diastolic (ED) pressure-volume relationship (PVR) using an arbitrary set of loading conditions. Ten isolated canine hearts with a balloon placed inside the left ventricle were used to determine the ESPVR and EDPVR. An end-diastolic volume (EDV) at a pressure of 15 mmHg and an end-systolic volume (ESV) at 70 mmHg were obtained from the EDPVR and ESPVR, respectively. EF was calculated as (EDV-ESV)/EDV. With low-dose (8 microg/min) and high-dose (40 microg/min) dobutamine infusion, the EF increased from 0.25+/-0.16 to 0.33+/-0.13 and 0.57+/-0.08 (p<0.01), respectively, in conjunction with increases in end-systolic elastance from 3.11+/-0.83 to 3.48+/-1.08 and 5.38+/-1.91 mmHg/ml (p<0.01). It was thus concluded that because the estimation of EF separates the heart from preload and afterload, this method may facilitate comparing overall pump function of hearts beating under different loading conditions.  (+info)

Carnosine as a potential anti-senescence drug. (7/9364)

The naturally occurring dipeptide carnosine (beta-alanyl-L-histidine) has been found to exert an anti-senescence effect when used as a dietary supplement. Carnosine clearly improved the external appearance of experimental animals and provided beneficial physiological effects, thus maintaining the animals in better condition than control animals receiving no carnosine or a mixture of beta-alanine and L-histidine.  (+info)

DNA vaccines. (8/9364)

DNA vaccination or genetic immunization is a rapidly developing technology that offers new approaches for the prevention and therapy of disease. Regarding the inoculation method of DNA vaccine, we recommend the gene gun delivery system, which is a highly reliable method compared to intramuscular inoculation. DNA vaccines could have potential advantages over other types of vaccines in that these vaccines can induce strong cellular immune responses, cytotoxic T lymphocytes and type 1 helper T cells, without resorting to live organisms or complicated protein formulation. The cellular immune responses are especially required for the protection against infections with intracellular pathogens such as viruses and Mycobacterium tuberculosis and protection against cancers, suggesting that they seem to be suitable targets of DNA vaccines. We describe here that their application to bacterial infections requires optimization of codon usage in the DNA vaccines to the host animal to improve translational efficiencies of the bacteria genes. DNA vaccines for a variety of pathogens and cancers have now entered phase I/II human clinical trials.  (+info)

Cross of two models from QPS: (1) APP751SL, which overexpresses mutant human APP (isoform 751) with the Swedish (K670N/M671L) and London (V717I) mutations under the control of the brain-specific Thy1 promoter, and (2) THMT, which overexpresses human MAPT (441) with the V337M and R406W mutations under the control of Thy1 ...
Animal models are organisms, often mice or rats, that have been engineered to reproduce the physical or molecular changes that occur during the course of a disease in humans. These models are used to study the biology of the disease, including the genetics and the cellular or molecular pathways involved in the disease. Animal models also have a critical role in developing and testing new therapies before they are tested in humans.. ...
We have gathered information about all of the relevant Charles River research models and associated services available to The University of Glasgow, along with pricing, special offers, resources, and contact details. We also provide expedited access to JAX™ Mice strains in Europe.
Charles River is committed to providing you with high-quality genetically standardized models such as VAF/Plus® (SPF) and VAF/Elite® (SOPF) animals which are free of select infectious agents and parasites. We understand that selecting the appropriate animal model for your studies is critical to your research success. To assist you, we offer an evaluation program that allows you to assess the quality and compatibility of our animal models before making a purchase.. ...
The influence of DHA/EPA enrichment of dairy products on visual/ brain development in infants and children (or the appropriate animal models ...
Greenmedinfo.com - Natural Health Resource - The worlds most widely referenced, open access, natural medicine database, with 30,000+ study abstracts and growing daily
Risk factors are things that can be causes. Like smoking is a risk factor and can cause heart disease. I dont think marmalade can cause CCSVI, but Id bet CCSVI, the risk factor (not the movie of the same name), ...
Large animal models have been widely used to facilitate the translation of mesenchymal stem cells (MSC) from the laboratory to patient. MSC, with their multi-po...
We welcome your input and comments. Please use this form to recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly ...
Greek & Greek1 claim that because animals and humans are different, Animal models are inaccurate, superfluous, and create risk to humans.
We are looking to buy a new thermocycler. I need it to run RAPDs. I would like high capacity, with heated lids and quick enough to run 2 or 3 reactions a day (including overnight). It will be for a university lab, so funds are limited. Does anybody know of a good reliable machine like, or close to this? I have heard good things about Perkin-Elmer models, bad things about Techne models, and both good and bad things about MJ research models ...
Coderre, T.J.; Xanthos, D.N.; Francis, L.; Bennett, G.J., 2004: Chronic post-ischemia pain (CPIP): a novel animal model of complex regional pain syndrome-type I (CRPS-I; reflex sympathetic dystrophy) produced by prolonged hindpaw ischemia and reperfusion in the rat
Animal models are an important means of studying diseases as well as normal functions. The animal model must closely mimic the situation we wish to study in humans. Humans are used as subjects in about 30 percent of all biomedical research, but they are not the best research subject when certain problems are studied.. Animal models can be categorized as natural or induced. Natural models are those in which a condition occurs spontaneously, such as atherosclerosis in the squirrel monkey. Atherosclerosis is a prevalent human disease in which fatty deposits occur along the inner walls of the arteries. By studying the natural disease in these monkeys, it is possible to learn facts about the disease that are also true in humans. Other examples of natural animal models are epilepsy in Mongolian gerbils and diabetes in some strains of mice.. Induced animal models are those in which a disease or condition must be artificially produced. Tumor cells, for example, can be injected into animals as a means of ...
DESCRIPTION (provided by applicant): Potassium (K+) channels serve diverse and critical roles in neuronal signaling and mutations in K+ channel genes have been linked to human neurological diseases such as epilepsy. Nevertheless, significant gaps still exist in our understanding of how K+ channels control neuronal excitability. For example, the Kv12 gene family is among the oldest and most highly conserved K+ channel families, yet the physiological function of these channels has not previously been examined in vivo due to a lack of genetic and pharmacologic tools. To address this knowledge gap, we have generated a mouse knockout of the voltage-gated K+ channel Kv12.2. The knockout mice have spontaneous epilepsy and a pronounced sensitivity to the chemoconvulsant pentylenetetrazol, suggesting a key role for Kv12.2 in the regulation of neuronal excitability. We find that hippocampal pyramidal neurons cultured from Kv12.2 knockout mice have significantly depolarized resting potentials, high input ...
Robet Koch formulated in 1890 the Koch´s postulates as general guidelines that should be followed to identify pathogens causing diseases. One century later, Stanley Falkow established the molecular version of Kochs postulates to guide, this time, the identification of microbial genes encoding virulence factors. A key point of the molecular postulates is to test the virulence of the microorganism with the inactivated candidate virulence gene in an appropriate animal model. However, this is not always possible. Suitable animals models are lacking for many diseases such as brucellosis, typhoid and leprosy. And the models for tuberculosis and cholera do not reflect the biology of human infections. In addition, large scale analysis of virulence are costs prohibited due to the high number of animals that should be infected to get statistically significant results. And, last but not least, there are important ethical concerns on the use of vertebrate animals models (including mice and rats) for ...
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Pre-Clinical Animal Network. Drug development is long and costly. To protect our investments, we need to be able to efficiently predict the safety and efficacy of drug candidates for PWS prior to sending them into clinical trials. The pre-clinical animal network, composed of expert model laboratories, will improve the predictive value of our PWS models and improve our ability to accurately predict drug safety and efficacy.. New Animal Models. Disease models are critical for therapeutic development in order to test the safety and efficacy of candidate drugs. Based on the input of experts, we will develop the new animal models of PWS needed to advance therapeutic development.. PWS cellular network. Modeling PWS in a cell is critical for screening drugs in a highthroughput fashion. We will develop a network of investigators to develop assays and cellular models of PWS for identifying new drugs, reposition existing drugs or discover new targets and pathways that can be used for investigating disease ...
Recently, a great number of theoretical frameworks have been proposed to develop the linkages between knowledge management (KM) and organizational strategy. While there has been much theorizing and case study in the area, validated research models integrating KM strategy and information technology (IT) strategy for empirical testing of these theories have been scarce. It is though that the rapid progress of IT has been provided a good solution to support KM practices. Choosing the proper ITs to fit with different KM strategies is critical for organizations. Effective KM activities require employing KM strategies, as well as IT, appropriately. That is, as long as the KM strategy has been determined within an organization, the IT strategy must be followed. In this present research, we try to develop and examine a research model for explaining the relationships between KM strategy, IT strategy, and their effects on performance. Empirical data for hypotheses testing are collected from top-ranked companies
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Neurological disease is a large and growing problem - despite billions of research dollars, the causes of most neurological disease are still not fully understood. For the most part treatments only help to alleviate symptoms and standard animal models are often quite limited, with many replicating only one aspect of the disease process as identified in a small minority of patients. Successful drug development programs require animal models that more faithfully replicate the human disease condition. CNS,CRO is pleased to offer these highly predictive models.. In addition, CNS,CRO offers a variety of behavioural tests for animal model assessment. Each test is adaptable, and our experienced team will work with you to design a testing regime tailored to suit your specific needs. ...
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an animal with a disease either the same as or like a disease in humans. Animal models are used to study the development and progression of diseases and to test new treatments before they are given to humans. Animals with transplanted human cancers or other tissues are called xenograft models.
Secreted proteins are important targets and biomarkers. Humanization of e.g. Immunoglobulin, transport proteins, Interleukins, and hormones provide very valuable research models.
Taconic Biosciences has remained one of the worlds leading providers of research models and services for over 60 years through our commitment to anticipating clients needs and industry trends.
Taconic Biosciences has remained one of the worlds leading providers of research models and services for over 60 years through our commitment to anticipating clients needs and industry trends.
We welcome your input and comments. Please use this form to recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly ...
Fetal Alcohol Spectrum Disorder (FASD) is a prevalent developmental disease that is caused by excess in utero exposure to ethanol. The importance of timing and dosage of ethanol has been elucidated by previous investigations conducted with humans, rodents, and other model organisms, but challenges associated with determining functional deficiencies have necessitated the introduction of a novel animal model for investigating the dynamics of FASD. In this thesis, we propose that the freshwater flatworm planarian species, Schmidtea mediterranea, has the capability to fulfill this need. Planaria have the ability to completely regenerate fragments into intact, functional animals, and in these studies, we exploited this property to characterize nervous system development in the presence of ethanol. Functional testing of head-regenerating planaria included planarian locomotor velocity testing to assess locomotor capabilities and light avoidance testing to assess development of innate negative phototaxic
TY - JOUR. T1 - A trial to find appropriate animal models of dichloropropane-induced cholangiocarcinoma based on the hepatic distribution of glutathione S-transferases. AU - Zhang, Lingyi. AU - Zong, Cai. AU - Ichihara, Sahoko. AU - Naito, Hisao. AU - Toyokuni, Shinya. AU - Kumagai, Shinji. AU - Ichihara, Gaku. PY - 2015. Y1 - 2015. N2 - Determinants of workplace violence against clinical physicians in hospitals: Jeng-Cheng WU, et al. Department of Urology, Taipei Medical University Hospital, Taiwan-Objectives: Workplace violence in the health sector is a worldwide concern. Physicians play an essential role in health-care teamwork; thus, understanding how organizational factors influence workplace violence against physicians is critical. Methods: A total of 189 physicians from three public hospitals and one private hospital in Northern Taiwan completed a survey, and the response rate was 47.1%. This study was approved by the institutional review board of each participating hospital. The 189 ...
Comparative Biosciences, Inc. provides expert scientific resources and quality service to all sectors of the biomedical and biopharmaceutical community. We offer extensive experience in GLP and non-GLP preclinical toxicology, efficacy, pharmacology, pharmacokinetics-pharmacodynamics, histopathology and safety studies on all laboratory species.
Neuroscience research in the Department aims to improve our understanding of the central nervous system and its involvement in the pathogenesis of disease. Areas of expertise and emphasis include regulation of feeding behavior and metabolism, sleep regulation, stress, neurodevelopment, and behavioral epigenetics. The generation and use of novel animal models of disease provides valuable tools and aids in the development of new drug targets and therapies in disease prevention and treatment.. To bridge basic research with clinical areas of expertise in neurology and behavior, the SOVM Neuroscience Center interacts with other Centers and Institutes at Penn, including:. ...
Cachexia, recognized by progressive loss of skeletal muscle and adipose tissue, contributes directly to morbidity and mortality in diseases as diverse as organ failure, AIDS, burn, trauma and cancer. Indeed, cachexia itself and not other effects of the tumor is thought to be the cause of up to 1/3 of all cancer deaths. Relatively little is understood regarding the molecular and cellular pathways leading to weight loss and dysmetabolism in cachexia and currently there are no approved, effective therapies. My group, working with a large and diverse group of collaborators, seeks to fill that knowledge gap by using novel animal models and correlative phenotypic and molecular data from patients to identify molecular, cellular and organ system mechanisms leading to cachexia. In this fashion we have:. 1. Identified a key role for IL-6/GP80/GP130/STAT3 in muscle and fat wasting in cancer and burns.. 2. Identified a causal role for Activins in burn-induced muscle wasting and shown efficacy in targeting ...
The Department of Defense (DoD) Ovarian Cancer Research Program (OCRP) supports high-impact, cutting-edge research that fills unmet needs. The OCRP establishes priorities to target the most critical needs along the pipeline from basic to translational to clinical research and to push the field of ovarian cancer forward in our vision to eliminate this disease.. The OCRP Pilot Award supports conceptually innovative, high-risk/high-reward research that could ultimately lead to critical discoveries or major advancements that will drive the field of ovarian cancer research forward. The proposed research must demonstrate a clear focus on ovarian cancer (e.g., using tissues, cell lines, datasets, or appropriate animal models, etc.). The proposed research should include a testable hypothesis based on strong scientific rationale and serve as a catalyst to expand or modify current thinking about and/or approaches in ovarian cancer. Preliminary data are not required, but are allowed, since the goal of this ...
Creative Animodel provides custom preclinical animal services for human hematopoiesis from model development, lead drug candidate efficacy studies, to toxicology testing.
A new investigational therapy has been detected for the treatment of bladder cancer. This discovery was made by a team of researchers led by the Columbia
On July 10, L-Nutra became the first company to market a product granted a patent by the US Patent & Trademark Office for optimizing human healthspan.
Buy your Healthspan Elite Levagen Plus Sport (60 Capsules) - Supplements from Wiggle. Our price $40.00. Free worldwide delivery available.
Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain. ...
Free Online Library: An SVAR model of fluctuations in U.S. migration flows and state labor market dynamics. by Southern Economic Journal; Business Economics Economic research Models United States economic conditions Research
The conscious sheep is an important large animal model for the study of human cardiovascular and cardiopulmonary system. In this study we develop a closed-loop mathematical model of its cardiovascular system. A distributed ...
Previously, the word healthspan has been used in many scientific contexts, but the definition has been ambiguous at best. Therefore, in this study, we focused on providing a conceptual framework of healthspan that can be easily verified in a laboratory setting using C. elegans. The current study makes no claim that the healthspan parameters tested cover all aspects of healthspan, nor does it make any assumptions that antiaging therapies that extend lifespan cannot coincide with an increase in healthspan. Rather, we highlight limitations of aging studies focused solely on lifespan extension.. Here we defined healthspan broadly by testing multiple assays as the animals aged. We tested wild type as our benchmark and then compared data from four long-lived mutants with wild-type health. From these data, we calculated and compared both the chronological number of days an animal is healthy vs. frail and the percent of the physiological lifespan the animal spends in each state (healthspan:gerospan ...
Joint Press Release: UNESCO-SAARC Alliance, HEC, SAIRI Initiative Pakistan). Pakistan has earned an upright and historic laurel of note to its credit through the bounteous magnanimity marked by the bench-mark IRT Model at the fore-fronts of the global academia. IRT is the first ever scientific research model on the phenomenon of teratogenesis in the broad-spectrum multi-causality perspectives of disability prevention.. The research-treatise, that is going to change the way-the world looks at the phenomenon of disability, is an outcome of nearly 1.5 decades inquiry-probings on the subject-matter by the fabled methodological analyst and the legendary adversarial multidisciplinary arch-researcher, Prof. Aurangzeb Al Hafi, whose name is no stranger to any state of affairs, when it comes to moral or humanistic convictions.. The revolutionary-edged research document that is primed for over 1900 universities of the globe, international hierarchies including the UN, the legislation ivories, ...
A new animal model for AIDS research has been developed by strengthening the HIV-1 virus and weakening the immune response of the pigtail macaque monkey. As it turns out, antiviral proteins in infected cells are key to the immune response in the animal.
Critical evaluation of radiolabeled lymphocytes to detect acute renal transplant rejection in a large animal model. - Get your full text copy in PDF #4818
Principal Investigator:NATA Koji, Project Period (FY):1996 - 1997, Research Category:Grant-in-Aid for Scientific Research (A), Section:展開研究, Research Field:Functional biochemistry
This organization was created during the 27th ESCPB (European Society for Comparative Physiology and Biochemistry) meeting in 2010 in Alessandria, Italy. A group of researchers interested in the use of bivalves as a research
Experimental animal models of muscle wasting in intensive care unit patients.: The muscle wasting and loss of muscle function associated with critical illness a
If you could buy a few more years of life by sacrificing some of your health, would you? When would the trade stop being worth it to you-when you lost your independence? Your eyesight? Your memories?. Scientists hunting for ways to extend lifespan often assume that the fruits of their labors will postpone frailty as well as death. But you dont need to look farther than humans to see that some things decrease the risk of death while increasing disease burden, like having the (mis-)fortune of being female. Thats why many believe the concept of healthspan is just as important to the success of longevity interventions as lifespan.. By and large, evidence has favored the intuitive conclusion that lifespan increases also benefit health. Long-lived model organisms tend to hold up better under duress and dont get age-related diseases as early as their control counterparts. But opposing evidence is trickling in as well: a 2015 study challenged the apparent success of past results, which had ...
Tracy Lee, Sandra Babich, Kasia Konopacki, John Chen, Jenna Moccia, and Bert Wognum STEMCELL Technologies Inc., Vancouver, BC, Canada STEMCELL
The zebrafish has become one of the most important model organisms to study biological processes within a living body. As a vertebrate that has many of the strengths of invertebrate model systems, it offers numerous advantages to researchers interested in many aspects of embryonic development, physiology and disease. This book not only provides a complete set of instructions that will allow researchers to establish the zebrafish in their laboratory.
The zebrafish has become one of the most important model organisms to study biological processes within a living body. As a vertebrate that has many of the strengths of invertebrate model systems, it offers numerous advantages to researchers interested in many aspects of embryonic development, physiology and disease. This book not only provides a complete set of instructions that will allow researchers to establish the zebrafish in their laboratory.
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Curationis provides a forum for cutting-edge theories and research models related to the exploration of issues experienced and the best practices of nurses and midwives so as to improve nursing education, nursing administration and community nursing within Africa.
The Eliopoulos lab in collaboration with the Liloglou team at the University of Liverpool uncovered a novel function of the TPL2 kinase as suppressor of lung carcinogenesis. By combining genomic analyses of human tumors with cell and animal model systems,Gkirtzimanaki, Gkouskou et al report the operation of multiple genetic and epigenetic mechanisms which lead to loss of TPL2 expression in lung tumors and link TPL2 to key pathways regulating the apoptosis barrier to cancer.. ...
The Eliopoulos lab in collaboration with the Liloglou team at the University of Liverpool uncovered a novel function of the TPL2 kinase as suppressor of lung carcinogenesis. By combining genomic analyses of human tumors with cell and animal model systems,Gkirtzimanaki, Gkouskou et al report the operation of multiple genetic and epigenetic mechanisms which lead to loss of TPL2 expression in lung tumors and link TPL2 to key pathways regulating the apoptosis barrier to cancer.. ...
La investigació semmarca en làmbit de lEnginyeria Biomèdica. Sadreça al disseny i desenvolupament de tècniques avançades de processament de senyals biomèdics multimodals per a la monitorització no invasiva, diagnòstic, prevenció i tractament de malalties. Explorem nous mètodes per a la interpretació dinformació clínicament rellevant dels senyals biomèdics. Lobjectiu és millorar el diagnòstic a través de la caracterització dels fenòmens fisiològics, aplicat a les principals malalties cardíacs, respiratories, neurològiques i trastorns del son. També desenvolupem bases de dades de biosenyals, realitzades conjuntament amb els hospitals per avaluar el rendiment dels algoritmes desenvolupats. I estudiem els algorismes proposats en models animals. El grup compta amb múltiples col·laboracions internacionals, incloent empreses i hospitals, dEuropa, Canadà i Estats Units. Actualment, els nostres prototipus sutilitzen als hospitals per recerca i per a un futur ...
Immunogen was an epitope corresponding to amino acids 181-236 mapping at the C-terminus of ASCL1 of human origin. (ZFIN Staff ...
Drug discovery screening, preclinical animal studies, cell line irradiation, cAMP Assays, Electrophysiology, MEA analysis Patch clamp recording, and more.
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: TECHNOLOGIES TO IMPROVE THE UTILITY OF ANIMAL MODELS PA-99-048. NCRR
Animal models[edit]. The phenomenon of infantile amnesia is not specific to humans. This initially was researched in rat models ... Of course, a main criticism of animal models is that development and cognition in animals and humans are starkly different. ... Research into the neural substrates of infantile amnesia using animal models has found that the major inhibitory ... research on animal models seems to indicate that childhood amnesia is not only due to the development of language or any other ...
Animal models[edit]. Several scientists have developed murine models of SSADH (Aldh5a1-/-) by typical gene methodology to ... This stress is believed to contribute to the formation of free radicals in the brain tissue of animal models induced with SSADH ... While this model is considered to be more severe than the phenotypes seen in humans, currently, it is the most highly regarded ... of GHB have been shown to induce spike and wave activity similar to that seen in generalized absence epilepsy in animal models ...
Animal models. PD is not known to occur naturally in any species other than humans, although animal models which show some ... what have we learned from pesticide-induced animal models?". Trends in Pharmacological Sciences. 30 (9): 475-83. doi:10.1016/j. ... Currently active research directions include the search for new animal models of the disease and studies of the potential ... Models based on toxins are most commonly used in primates. Transgenic rodent models that replicate various aspects of PD have ...
Premature aging also develops on some animal models which have genetic alterations.[86][87] Although the patients with these ... syndromes and the animal models with premature aging symptoms have different genetic backgrounds, they all have abnormal ...
Animal models[edit]. Studies of human diseases have benefited from the availability of small laboratory animal models. However ... "DEVELOPMENT OF ROBUST ANIMAL MODELS FOR VITAMIN C FUNCTION". Open Access Dissertations and Theses. McMaster University Library ... the tissues of animal models with a GULO gene generally have high levels of ascorbic acid and so are often only slightly ... Plant models[edit]. In plants, the importance of Vitamin C in regulating whole plant morphology, cell structure, and plant ...
Animal models[edit]. Mice genetically engineered to lack glutathione peroxidase 1 (Gpx1−/− mice) are grossly phenotypically ...
Animal models of depression. Models of depression in animals for the purpose of study include iatrogenic depression models ( ... Krishnan V, Nestler EJ (2011). "Animal Models of Depression: Molecular Perspectives". Molecular and Functional Models in ... Animals models. Further information: Animal psychopathology § Depression. Further information: ... The first model proposed is the "Limbic Cortical Model", which involves hyperactivity of the ventral paralimbic regions and ...
Animal Models[edit]. During the discovery of Myc gene, it was realized that chromosomes that reciprocally translocate to ... In all these mouse models overexpression of Myc causes tumorigenesis, illustrating the potency of Myc oncogene. In a study with ... transgenic mouse models were developed. Myc gene placed under the control of IgM heavy chain enhancer in transgenic mice gives ... The phenotypes seen oppose the effects of normal aging and are shared with many other long-lived mouse models such as CR ( ...
Animal models[edit]. There are vast ethical limitations in drug addiction research because humans cannot be allowed to self- ... Animal studies suggest that there exists a difference in D2 receptor availability between dominant and subordinate animals ... The validity of the model can be examined in three ways: formal equivalence, correlational models, and functional equivalence. ... This schedule is maintained until the animals learn the task.[14] Extinction[edit]. Extinction in non-human primates is ...
Animal-based fibers such as wool and leather also have quite the impact on the environment, being responsible for 14.5% of ... "Results , Global Livestock Environmental Assessment Model (GLEAM) , Food and Agriculture Organization of the United Nations". ... CO2 and N2O are released into the atmosphere as byproducts of raising the animals. In total, 44% of emissions caused by ... Animal Frontiers. 9 (1): 69-76. doi:10.1093/af/vfy034. ISSN 2160-6056. PMC 7015462. PMID 32071797. " ...
... animal tamer; market woman, town crier, barker; performing artist (vaudeville, acrobat, circus performer), orator; model; ... Sadistic jobs type are truck driver, farm servant, animal tamer, veterinary, manicure, pedicure, animal slaughter, surgical ... In contrast to Freud's work, Szondi's approach is based on a systematic drive theory and a dimensional model of personality. ... The work objects of the sadistic professions are animals, stone, iron, metal, machinery, soil, wood; the work circumstances are ...
Simmons, L.W. (1991). "On the post-copulatory guarding behaviour of male field crickets". Animal Behaviour. 42 (3): 504-505. ... Ecological Modelling. 65 (3-4): 265-280. doi:10.1016/0304-3800(93)90083-5. Tinghitella, Robin M.; Zuk, Marlene (2009). " ... Animal Behaviour. 76 (3): 1065-1071. doi:10.1016/j.anbehav.2008.02.018. Simmons, L. W.; Thomas, M. L.; Simmons, F. W.; Zuk, M ... Animal Behaviour. 72 (4): 809-818. doi:10.1016/j.anbehav.2006.01.019. Thomas, M. L.; Simmons, L. W. (2011). "Crickets detect ...
"Stanija Dobrojević gola za Playboy". Big Animal. Retrieved July 22, 2018. "Ko je bio otac Stanije Dobrojević?". Alo. July 7, ... "MAXIM Serbia: November 2011". Fashion Model Directory. Retrieved July 22, 2018. "Stanija Dobrojevic: Serbian Sensation". ... is a Serbian television personality and glamour model. She rose to prominence as a contestant on Survivor Srbija VIP: Costa ... second runner-up List of glamour models Gasic, Djordje (July 13, 2011). "Worldwide Wednesday: The 10 Hottest Serbian Women". ...
Dawkins, Richard (1969). "A threshold model of choice behaviour". Animal Behaviour. 17 (1): 120-133. doi:10.1016/0003-3472(69) ... Dawkins's research in this period concerned models of animal decision-making. From 1967 to 1969, Dawkins was an assistant ... Tinbergen was a pioneer in the study of animal behaviour, particularly in the areas of instinct, learning, and choice; ... Similarly, Robert Trivers, thinking in terms of the gene-centred model, developed the theory of reciprocal altruism, whereby ...
These models are most often applied to sexually selected signalling in diploid animals, but they rarely incorporate a fact ... Given that animals cannot synthesize carotenoids de novo, these must be obtained from food. The hypothesis states that animals ... Other models incorporate both costly signalling and Fisherian runaway. These models show that if fitness depends on both ... The game theoretical model of the war of attrition similarly suggests that threat displays ought not to convey any reliable ...
Although commonly used in the context of food or shelter, the resource competition model can be applied to other limited ... Animal Behaviour. 62 (5): 905-915. doi:10.1006/anbe.2001.1835. Hestermann, M.; Ziegler, T.; van Schaik, C. P.; Launhardt, K.; ... Harcourt, A.H.; Greenberg, J. (November 2001). "Do gorilla females join males to avoid infanticide? A quantitative model". ... Most callitrichids have restrictive breeding patterns, which would be compatible with the model, but this infanticide behavior ...
"Diabetic Animal Models". In Hau J, Van Hoosier Jr GL (eds.). Handbook of Laboratory Animal Science. Animal Models. II (Second ... Merkel cell polyomavirus closely related to SV40 and mouse polyomaviruses that have been used as animal models for cancer ... The viruses that infect plants are harmless to animals, and most viruses that infect other animals are harmless to humans. The ... Viral infections in animals provoke an immune response that usually eliminates the infecting virus. Immune responses can also ...
... such as Animal Behaviour, Animal Welfare, Applied Animal Behaviour Science, Animal Cognition, Behaviour, Behavioral Ecology and ... Hoppitt, W.; Laland, K. N. (2013). Social Learning: An Introduction to Mechanisms, Methods, and Models. Princeton University ... in animals Animal communication Anthrozoology Behavioral ecology Cognitive ethology Deception in animals Emotion in animals ... Habituation is a simple form of learning and occurs in many animal taxa. It is the process whereby an animal ceases responding ...
Kinematic Models for Design Digital Library (KMODDL), featuring movies and photos of hundreds of working models of mechanical ... ISBN 978-1-4020-5441-9.. A. Biewener (2003). Animal Locomotion. Oxford University Press. ISBN 019850022X. J. M. McCarthy and G ... ISBN 978-0-521-54411-5. P. P. Teodorescu (2007). "Kinematics". Mechanical Systems, Classical Models: Particle Mechanics. ...
Animal models in neuroscience '. i J Hau & SJ Schapiro (red), Handbook of Laboratory Animal Science: Vol. II. Animal Models. 3 ... model that deals with the seeming contradiction between the localization and post-traumatic recovery of various functions in ...
In 1986, the Arabian oryx was classified as endangered on the IUCN Red List, and in 2011, it was the first animal to revert to ... Ecological Modelling. 210 (1-2): 169. doi:10.1016/j.ecolmodel.2007.07.015. Platt, John (17 June 2011). "Arabian Oryx Makes ... It is the national animal of Oman. The taxonomic name Oryx leucoryx is from the Greek orux (gazelle or antelope) and leukos ( ... The Arabian oryx is the national animal of Jordan, Oman, the United Arab Emirates, Bahrain, and Qatar. The Arabian oryx is also ...
All models are simplified abstractions of the real-life situation. There exists a basic tradeoff between model precision and ... Jeanson, R (2012). "Long-term dynamics in proximity networks in ants". Animal Behaviour. 83 (4): 915-923. doi:10.1016/j.anbehav ... Stephen P. Ellner & John Guckenheimer (2006). "Building dynamic models". Dynamic Models in Biology. Princeton University Press ... such models should generally be kept simple. Therefore, we generally should not expect models for social insect task allocation ...
... s can sometimes be modeled to form shapes of animals. Table decorations normally appear with three or five balloons on ... Modelling and use in art. Balloon artists are entertainers who twist and tie inflated tubular balloons into sculptures such as ... animals (see balloon modelling). The balloons used for sculpture are made of extra-stretchy rubber so that they can be twisted ... When that happens, it can lead to negative effects for the animals. For example, a bird will use a deflated balloon as a ...
"Research Animal Models". CRiver.com. Charles River Laboratories. Archived from the original on 24 May 2013. Retrieved 5 August ... While less commonly used for research than mice, rats have served as an important animal model for research in psychology and ... Like NOD mice, Biobreeding rats are used as an animal model for Type 1 diabetes. The strain re-capitulates many of the features ... Krinke GJ, Bullock GR, Krinke G (June 15, 2000). "History, Strains and Models". The Laboratory Rat (Handbook of Experimental ...
"Research Animal Models". CRiver.com. Charles River Laboratories. Archived from the original on 24 May 2013. Retrieved 5 August ... Like NOD mice, biobreeding rats are used as an animal model for Type 1 diabetes. The strain re-capitulates many of the features ... While less commonly used for research than mice, rats have served as an important animal model for research in psychology and ... The Zucker rat was bred to be a genetic model for research on obesity and hypertension. They are named after Lois M. Zucker and ...
Animal model - frog. Tivimiton - The vice-commander of the Animal forces belongs to the cohorts of Androids, good robots that ... Animal model - a BIG mouse. Branny - A skinny scientist who realises that he's been doing the wrong thing all his life, and ... Animal model - lion. Primatron - No prizes for guessing who this character is inspired from. This is the overlord of all robot ... Animal model - dog. Randy - Plays the role of anti-Effdee: Cantankerous, wise-cracking and clumsy. As a mercenary, Randy is ...
... modelling animal systems; physiology and endocrinology; ruminant nutrition; non-ruminant nutrition; and welfare, behaviour, and ... contains research on animal agriculture and animal products, including breeding and genetics; cellular and molecular biology; ... Biochemistry and Cell Biology Botany Canadian Geotechnical Journal Canadian Journal of Animal Science: ...
Crain, D. A.; Guillette Jr, L. J. (1998). "Reptiles as models of contaminant-induced endocrine disruption". Animal Reproduction ... Animals including humans may be poisoned by pesticide residues that remain on food, for example when wild animals enter sprayed ... Pesticides can eliminate some animals' essential food sources, causing the animals to relocate, change their diet or starve. ... Animal studies mostly focus on fish, insects, birds, amphibians and arachnids. Since 1993, the United States and the European ...
Crossland, J.; Lewandowski, A. (2006). "Peromyscus - A fascinating laboratory animal model" (PDF). Techtalk. 11: 1-2. Archived ... While most rodents are polygamous, the California mouse is monogamous and forms pair bonds, making it a model organism for ... Animal Behaviour. 54 (2): 377-386. doi:10.1006/anbe.1996.0583. PMID 9268470. S2CID 7797715. ...
"Defensive posture and eyespots deter avian predators from attacking caterpillar models". Animal Behaviour. 86 (2): 383-389. doi ...
Advances in the fields of molecular biology and genetics, as well as the use of animal models have been of great importance in ... Research in animal models has led to the idea that the dura mater plays an important role in determining closure or patency of ...
... but do not offer advantages compared with diets which allow moderate amounts of animal products.[100] There is not enough ... "Projections of type 1 and type 2 diabetes burden in the U.S. population aged ,20 years through 2050: dynamic modeling of ...
Districts started embracing the magnet school models in the hope that their geographically open admissions would end racial ... Other schools are built around elite-sporting programs or teach agricultural skills such as farming or animal breeding. ... Magnet schools still continue to be models for school improvement plans and provide students with opportunities to succeed in a ...
Elton CS (1927) Animal Ecology. Republished 2001. University of Chicago Press. *^ Allee, W. C. (1932). Animal life and social ... Ecologists use simplified one trophic position food chain models (producer, carnivore, decomposer). Using these models, ... Journal of Animal Ecology. 78: 253-269. doi:10.1111/j.1365-2656.2008.01460.x. Archived from the original (PDF) on 2011-09-16.. ... Ecological Modelling. 220 (11): 1376-1382. doi:10.1016/j.ecolmodel.2009.03.005. Archived from the original (PDF) on 2011-10-07. ...
They started to test L-735,524 on animals a couple months later and found that it was safe for animals. Consequently, the ... 3D model (JSmol). *Interactive image. SMILES. *. CC(C)(C)NC(=O)[[email protected]@H]1CN(CCN1C[[email protected]](C[[email protected]@H](Cc2ccccc2)C(=O)N[[email protected]]3c4ccccc4C[[email protected] ...
Ayurveda stresses the use of plant-based medicines and treatments, with some animal products, and added minerals, including ... and an incorrect model of the anatomy and physiology of internal organs.[8][59][60][61][62][63] ... Substance based practices use substances found in nature such as herbs, foods, non-vitamin supplements and megavitamins, animal ... but may also include the use of animal and mineral products.[74] It is among the most commercially successful branches of ...
The plants and animals of the Miocene were recognizably modern. Mammals and birds were well-established. Whales, pinnipeds, and ... and thus modern cycads are not a good model for a "living fossil".[17] ...
One possible way to achieve this, which has been successful in mouse models, is to use inhibitors of Ras activation in order to ... Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells. The first two ...
... was used to shelter animals in bad weather. A raba was a higher-status dwelling, distinguished by a north-facing entrance, ... any of the boatmen would have made an excellent model for an Hercules; and one in particular, with uncombed hair and shaggy ...
Text is available under the Creative Commons Attribution-ShareAlike License; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc., a non-profit organization ...
B. J. Braakhuis u. a.: The potential of the nude mouse xenograft model for the study of head and neck cancer. In: Archives of ... Laboratory Animals: Origin of Nude Mouse. In: Nature 224/1969, S. 114-5. ... S. Loisel u. a.: Establishment of a novel human B-CLL-like xenograft model in nude mouse. In: Leukemia Research 29/2005, S. ... combretastatin A4 phosphate and paclitaxel is effective against anaplastic thyroid cancer in a nude mouse xenograft model. In: ...
talk , contribs)‎ (→‎Modeling: Started new section.). *(diff , hist) . . m Ugly law‎; 09:36 . . (+19)‎ . . ‎. Rodw. (talk , ... Animal testing‎; 16:22 . . (-90)‎ . . ‎. Dawnseeker2000. (talk , contribs)‎ (Typo fixing, refine ref details, typo(s) fixed: a ...
Small animal imagingEdit. PET technology for small animal imaging: A miniature PE tomograph has been constructed that is small ... since more sophisticated models of the scanner Physics can be incorporated into the likelihood model than those used by ... animal diagnosis. Because of cost as well as the marginal utility of detecting cancer metastases in companion animals (the ... Vardi, Y.; L. A. Shepp; L. Kaufman (1985). "A statistical model for positron emission tomography". Journal of the American ...
Research from animals has consistently shown that when a trial is repeatedly exposed to a painful stimulus, the animal's pain ... Volkow ND, Koob GF, McLellan AT (January 2016). "Neurobiologic Advances from the Brain Disease Model of Addiction". N. Engl. J ... In animals, cross-sensitization has been established between the consumption of many different types of drugs of abuse - in ... Thus, kindling has been suggested as a model for temporal lobe epilepsy in humans, where stimulation of a repetitive type ( ...
In studies of rats, animals fed a diet of 50% sweet pea seeds developed enlarged adrenals relative to control animals fed on ... The sweet pea is thus a model organism being used in early experimentations in genetics, particularly by the pioneer geneticist ...
Feugier, François (14 December 2006). Models of Vascular Pattern Formation in Leaves (PhD Thesis). University of Paris VI.. ... Animals that are specialized to eat leaves are known as folivores. Some species have cryptic adaptations by which they use ... Read and Stokes (2006) consider two basic models, the "hydrostatic" and "I-beam leaf" form (see Fig 1).[40] Hydrostatic leaves ... The leaf is a vital source of energy production for the plant, and plants have evolved protection against animals that consume ...
Disease models. Animal models and in particular non-human primates are being used to study different aspects of Ebola virus ... Other animals. Wild animals. Ebola has a high mortality rate among primates.[241] Frequent outbreaks of Ebola may have resulted ... Animals may become infected when they eat fruit partially eaten by bats carrying the virus.[82] Fruit production, animal ... Blood samples were taken from 178 animal handlers during the incident.[249] Of those, six animal handlers eventually ...
For this reason, it has been used as a model to study pathological conditions such as apnea of prematurity and sudden infant ... Their actions are diverse and dependent upon the activity level and species of the animal. Serotonin plays a critical role in ... The pre-BötC complex operates in animals as part of a larger network that receives critical information and signaling inputs ... Rubin JE, Shevtsova NA, Ermentrout GB, Smith JC, Rybak IA (April 2009). "Multiple Rhythmic States in a Model of the Respiratory ...
Miniature Votive Images or Toy Models from Harappa, ca. 2500. Hand-modeled terra-cotta figurines with polychromy. ... and a number of animals, including the humped bull, were domesticated,"[11] as well as "fowl for fighting".[12] Wheel-made ... seals engraved with human or animal motifs. A large number of seals have been found at such sites as Mohenjo-Daro and Harappa. ... pottery-some of it adorned with animal and geometric motifs-has been found in profusion at all the major Indus sites. A ...
The third chimpanzee: the evolution and future of the human animal.. *^ a b Sharman Apt Russell (2006). Hunger an unnatural ... According to current archaeological and genetic models, there were at least two notable expansion events subsequent to peopling ... and women may have procured small game animals for consumption and assisted men in driving herds of large game animals (such as ... may have had their origins in these hypothetical Middle Paleolithic animal cults.[90] Animal worship during the Upper ...
"A Small Animal Model of ETEC-Mediated Diarrhea - Grand Challenges". gcgh.grandchallenges.org.. ... "A Small Animal Model of ETEC-Mediated Diarrhea".[7][8] ...
In recognition of the basic concepts he has contributed to the study of animal ecology which, with his foundation of the Bureau ... developing models for the evolution of genetic systems, including sex and recombination, inbreeding and outbreeding, separate ... for his outstanding work on the diversity of animal societies and demonstration of their effects on the evolution of ... For his work on extended oceanographical expeditions; and for his genetic studies in animals and plants. ...
Other animal species. See also: Tool use by animals, Structures built by animals, and Ecosystem engineer ... though most analysts resist the model that technology simply is a result of scientific research.[19][20] ... The use of basic technology is also a feature of other animal species apart from humans. These include primates such as ... evidence of burnt animal bones at the Cradle of Humankind suggests that the domestication of fire occurred before 1 Ma;[26] ...
Abortion may also be induced in animals, in the context of animal husbandry. For example, abortion may be induced in mares that ... but the parallelism between the DMBA-induced rat mammary carcinoma model and the human situation is striking. …Abortion would ... "Animal Behaviour 59: 689-694. http://af.czu.cz/~bartos/publications/pdf/Pluhacek_Bartos_2000_AB.pdf. ...
World Animal Foundation. Retrieved 12 April 2017.. *^ Simon, Matt (16 January 2015). "Absurd Creature of the Week: The ... Yekutieli, Y.; Sagiv-Zohar, R.; Aharonov, R.; Engel, Y.; Hochner, B.; Flash, T. (2005). "Dynamic model of the octopus arm. I. ... Journal of Applied Animal Welfare Science. Lawrence Erlbaum Associates. 7 (2): 95-106. doi:10.1207/s15327604jaws0702_2. PMID ... Captive animals have been found to be more susceptible to pathogens than wild ones.[106] A gram-negative bacterium, Vibrio ...
Hart BL (1988). "Biological basis of the behavior of sick animals". Neurosci Biobehav Rev. 12 (2): 123-37. doi:10.1016/S0149- ... "Tramadol has a better potency ratio relative to morphine in neuropathic than in nociceptive pain models". Drugs in R&D. 8 (1): ... receptor antagonist neramexane in a human surrogate model of neurogenic Hyperalgesia". Eur J Pain. 12 (1): 17-29. doi:10.1016/j ... Various studies of humans and animals have demonstrated that primary or secondary hyperalgesia can develop in response to both ...
For example, Agrobacterium tumefaciens is a plant pathogen, Brucella abortus is an animal pathogen, and Sinorhizobium meliloti ... In this model TipN specifies the site of the most recent division by identifying the new pole. The cell uses this positional ... Its name derives from its crescent shape caused by the protein crescentin.[2] Its use as a model originated with developmental ... Caulobacter is an important model organism for studying the regulation of the cell cycle, asymmetric cell division, and ...
A model attribution edit summary (using German): Content in this edit is translated from the existing German Wikipedia article ... The number and ratio of rods to cones varies among species, dependent on whether an animal is primarily diurnal or nocturnal. ... This is the mechanism that allows trichromatic color vision in humans and some other animals. ...
Nosokinetics is the science/subject of measuring and modelling the process of care in health and social care systems. ... Throughout history and in Europe right until the late 18th century, not only animal and plant products were used as medicine, ... Conservation medicine studies the relationship between human and animal health, and environmental conditions. Also known as ... Before this, medical doctors treated both humans and other animals. Modern scientific biomedical research (where results are ...
... front-heavy beaked quadrupedal animals) such as Ischigualastia and traversodontid cynodonts (somewhat similar in overall form ... Model depicted with prey. The holotype of Herrerasaurus (PVL 2566) was discovered in the Cancha de Bochas Member of the ... dinosaurs were becoming the dominant large land animals, and the other archosaurs and synapsids declined in variety and number. ... although the relationships of these animals are not fully understood, and not all paleontologists agree. Other possible basal ...
Animal testing Institutional Animal Care and Use Committees Pit of despair, an apparatus used for animal models of clinical ... Therefore, animal models of depression often display altered anxiety-related behavior. An appropriate animal model of human ... model is probably the most valid animal model of depression. It aims to model a chronic depressive-like state that develops ... It is difficult to develop an animal model that perfectly reproduces the symptoms of depression in patients. Many animals lack ...
All MeSH CategoriesDiseases CategoryAnimal DiseasesDisease Models, Animal. All MeSH CategoriesAnalytical, Diagnostic and ... Disease Models, Animal. Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to ... Therapeutic Techniques and Equipment CategoryInvestigative TechniquesModels, AnimalDisease Models, AnimalArthritis, ... All MeSH CategoriesAnalytical, Diagnostic and Therapeutic Techniques and Equipment CategoryInvestigative TechniquesModels, ...
Van den Berg WB (2001) Lessons from animal models of osteoarthritis. Curr Opin Rheumatol 13:452-456.PubMedCrossRefGoogle ... Bendele AM (2002) Animal models of osteoarthritis in an era of molecular biology. J Musculoskel Neuron Interact 2(6) 501-503. ... Brandt KD (2002) Animal models of osteoarthritis. Biorheology 39:221-235.PubMedGoogle Scholar ... Bendele AM (2001) Animal models of osteoarthritis. J Musculoskel Neuron Interact 1(4):363-376.Google Scholar ...
Limitations and utility of current models, issues regarding translatability, and future directions for developing animal models ... and future directions for developing animal models of these human disorders. The authors review the current state of rodent ... of mechanistically designed therapeutics can still benefit from more rigorous use of the models and from generation of animals ... Here we review the current state of rodent models for Alzheimers disease, Parkinsons disease, frontotemporal dementia, and ...
In Animal Models for Retinal Diseases, recognized experts in the field highlight valuable techniques as well as animal models ... and appropriate study models, especially animal models, are essential to furthering our understanding of the etiology, ... Animal Models for Retinal Degeneration Marijana Samardzija, Stephan C. F. Neuhauss, Sandrine Joly, Malaika Kurz-Levin, ... Vital and easy to use, Animal Models for Retinal Diseases serves to support the important future research of ocular ...
Our core develops genetic technologies and model systems aimed at investigating genes and pathways to yield insight into how ... Genetic Animal Models Core. Develops novel genetic technologies and model systems aimed at investigating genes and pathways to ... The Genetic Animal Models Core provides emerging genetic technology and model systems that enable transformative investigation ... Models of host defense. *Access to a bank of genotyped mouse- and human-derived intestinal organoids as well as tools, ...
... Guest Edited by Dr Kirsten Lauber.. Radiotherapy is a central element of multimodal ... A new tissue segmentation method to calculate 3D dose in small animal radiation therapy In pre-clinical animal experiments, ... These small animal radioth... Authors: Mihaela Ghita, Stephen J. McMahon, Hannah F. Thompson, Conor K. McGarry, Raymond King, ... A dosimetric model for the heterogeneous delivery of radioactive nanoparticles In vivo: a feasibility study Accurate and ...
This new model is yielding promising results [109].. 4.3. Large Animal Models of Heart Failure. Small animal models have ... 4. Animal Models of Heart Failure. Models of heart disease in small animals, particularly rats, have been very useful for the ... 3. Animal Models of Abdominal Aortic Aneurysms (AAAs). Animal models of atherothrombotic AAA are essential tools for the ... Here we will describe models of atherothrombotic diseases, including expanding and occlusive animal models, as well as models ...
Animal models in oral cancer research.. Mognetti B1, Di Carlo F, Berta GN. ... Biologically and clinically relevant animal models are essential in investigation of the progression of diseases and the ... The several rodent models used for in vivo evaluation for oral cancer employ chemical, transplantation and genetic (knockout ... These models are described together with their advantages and disadvantages. Their optimization and application in future ...
"Most animals, whether its a bird or something else, when theyre presented with a lot of loud noise they just leave," Luther ... All model organisms share a few common traits: theyre inexpensive, easy to care for, grow quickly and are relatively simple ... "But there are some animals that persist. If we find out how and why theyre able to persist, we could apply this to other ... "Model organisms are vital for biological research," says Robert Miller, a deputy division director in the National Science ...
The reasons animal models cannot predict human response to drugs and disease are to be found in a study of evolutionary biology ... The reasons animal models cannot predict human response to drugs and disease are to be found in a study of evo... ... This illustrates another problem with using animal models. Not only are animal models misleading for human response to drugs ... No doubt the drugs were tested, and will be tested again, in animals but this begs the question whether animal models can ...
... George L. Wolff GWOLFF at NCTR.FDA.GOV Thu Feb 22 14:36:13 EST 1996 *Previous message: Pyrethrum ... Instead of determining toxicity of xenobiotics in test animals by using the dose response approach, I would like to bring up ... This concept proposes that an array of genotypes, conferring different degrees of susceptibility of the animals to the toxic ... without increasing the total number of animals in the bioassay - to mimic some of the diversity of genotypes and sensitivities ...
Animal model for benign prostatic disease. US5175384 *. Dec 5, 1988. Dec 29, 1992. Genpharm International. Transgenic mice ... there is a need in the art for suitable animals that provide in vivo model systems for studying the diseases and compounds that ... Transgenic model for heart failure. US6392118 *. May 23, 1995. May 21, 2002. Neurotech S.A.. Mx-1 conditionally immortalized ... Transgenic animals, cells and cell lines therefrom, and their use. WO1992006190A1 *. Oct 1, 1991. Apr 16, 1992. Massachusetts ...
... and the development of new animal models that can be used to study these disorders continues to stimulate new research. Animal ... Models of Eating Disorders serves as a collection of detailed techniques ... Authoritative and practical, Animal Models of Eating Disorders aims to aid researchers in the use of animal models to assist in ... Animal Models of Eating Disorders. Editors. * Nicole M. Avena Series Title. Neuromethods. Series Volume. 74. Copyright. 2013. ...
... we summarize and critically appraise current small and large animal models of CAVD, discuss the utility of animal models for ... Animal models are emerging as vital tools to this end, facilitated by the advent of new models and improved understanding of ... Animal Models of Calcific Aortic Valve Disease. Krista L. Sider,1 Mark C. Blaser,1 and Craig A. Simmons1,2,3 ... and provide recommendations for future animal model studies of CAVD. ...
KO animal portfolio, one that allows Taconic to promote and sell FRG™ primary cell xenograft animal models and HepaCur™ human ... KO animal portfolio, one that allows Taconic to promote and sell FRG™ primary cell xenograft animal models and HepaCur™ human ... Humanized animal models have been developed through genetic modification to provide specific attributes that are genetically ... that replaces the native animal organ systems. The modified animals have a range of human attributes passed on from the human ...
... [Internet]. Salt Lake City (UT): Genetic Science Learning Center; 2013 [cited 2018 Dec 7] ... Because animals and humans share the reward pathway-and most of the genes that govern it-animals are also susceptible to drug ... 2013, August 30) Animal Models for Addiction Research. Retrieved December 07, 2018, from https://learn.genetics.utah.edu/ ... Animal Models for Addiction Research. Learn.Genetics. August 30, 2013. Accessed December 7, 2018. https://learn.genetics.utah. ...
The Animal Models Core consists of two subdivisions, the Rodent Genetics Core and the Biobehavioral Research Core. We provide ... comprehensive services for a variety of animal research projects on genetically modified rodents and animal behavior. ...
Animal models of erectile dysfunction. Erectile dysfunction (ED) is a prevalent male sexual dysfunction with profound adverse ... Animal Modelling of Interstitial Cystitis/Bladder Pain Syndrome. The etiology of interstitial cystitis/bladder pain syndrome ( ... and neurophysiological studies using various animal models have provided important insights into human sexual dysfunction. ... Modeling human bladder cancer. Bladder cancer is a major public health concern and the treatment options available are unable ...
Animal models and lncRNA profiling. Animal models generate a variety of tissue and cell types from which to profile lncRNA ... Diversity of animal models. Animal models vary in biological complexity, which can be leveraged depending on the area of ... Here, we highlight the diversity of animal models and their unique advantages, discuss the use of animal models to profile ... This complementary use of animal models to investigate lncRNA function highlights the utility of animal models when exploring ...
Scripps Research Animal Models Core Facility has been established to provide a wide range of in vivo tests to the Scripps ... Assays are designed for mouse phenotyping or for drug intervention in mouse models, and a wide range of behavioral paradigms is ... Included in a service package is experimental design advice, assistance with IACUC animal protocol submission, assistance with ... tests that allow investigators to make transitions from laboratory findings to clinical applications by enabling the modeling ...
Sakima A. Smith, Amy C. Sturm, Jerry Curran, Crystal F. Kline, Sean C. Little, Ingrid M. Bonilla, Victor P. Long, Michael Makara, Iuliia Polina, Langston D. Hughes, Tyler R. Webb, Zhiyi Wei, Patrick Wright, Niels Voigt, Deepak Bhakta, Katherine G. Spoonamore, Chuansheng Zhang, Raul Weiss, Philip F. Binkley, Paul M. Janssen, Ahmet Kilic, Robert S. Higgins, Mingzhai Sun, Jianjie Ma, Dobromir Dobrev, Mingjie Zhang, Cynthia A. Carnes, Matteo Vatta, Matthew N. Rasband, Thomas J. Hund and Peter J. Mohler ...
However better animal models that more accurately recapitulate the natural progression of the disease are needed for the ... However better animal models that more accurately recapitulate the natural progression of the disease are needed for the ... Towards a better understanding of the molecular pathogenesis of human OS several genetically modified OS mouse models have been ... Towards a better understanding of the molecular pathogenesis of human OS several genetically modified OS mouse models have been ...
Based on this experience, we can develop customized animals models with specific isolates or new pathogens for customers. ... We have a broad portfolio of animal models for various pathogens, which can be supported with extensive laboratory analyses. ... Animal models for animal health. We have a broad portfolio of animal models for various pathogens, which can be supported with ... Is your model not listed? If your animal model of interest is not listed, please contact our experts Riks Maas (virological ...
In addition, our animal models can be used for translational clinical and preclinical studies into human diseases. ... We offer more insight into the epidemiology, transmission and pathogenesis of zoonoses in animal and human cases. ... Many animal models developed within Wageningen Bioveterinary Research (WBVR) provide insights into human health issues. ... Animal models for human health. Many animal models developed within Wageningen Bioveterinary Research (WBVR) provide insights ...
... the worlds leading provider of digital 3D models for visualization, films, television, and games. ... Rhino.3ds.zip 3D Model available on Turbo Squid, ... Imagination Works 3D Animal Models, superbly detailed in 3ds or ... All iw43d models built to scale-extremely efficient mesh-fully texture mapped-all materials included-movable parts that can be ...
... animal models of disease, and basic biologic mechanisms related to disease in people and animals. ... A variety of animal species have been used to study both the acute and chronic forms of the disease. Although none of the ... Models using species from mice to nonhuman primates have been used to evaluate and characterize vaccines to protect against the ... information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal ...
... investigators have studied a variety of animal models to gain insights into immunopathogenetic mecha... ... To date, no animal model has been developed that exhibits all of the attributes of PSC. Rodent models instigated by bacteria] ... Future studies in either existing or new animal models should advance our understanding of the pathogenesis of PSC, the major ... investigators have studied a variety of animal models to gain insights into immunopathogenetic mechanisms associated with ...
The study of animal movement has always been a key element in ecological science, because it is inherently linked to critical ... Animal Movement Statistical Models for Telemetry Data By Mevin B. Hooten. , Devin S. Johnson. , Brett T. McClintock. , Juan M. ... and statisticians who seek a deeper understanding of modern animal movement models. A wide variety of modeling approaches are ... including spatial point process models, discrete-time dynamic models, and continuous-time stochastic process models. The book ...
Use of animal models provides important knowledge about pathological conditions… ... Animal Models in Orthopaedic Research is a reference book of the major animal models used in the study of orthopaedic ... Animal Models of Spinal Conditions. Animal Models of Spinal Instability and Spinal Fusion, H.S. Sandhu, L.E.A. Kanim, F. ... Animal Models in Orthopaedic Research is a reference book of the major animal models used in the study of orthopaedic ...
  • As wild-type mice are resistant to lesion development, the current mouse models for atherosclerosis are based on genetic modifications of lipoprotein metabolism with additional dietary changes. (hindawi.com)
  • Taconic, who has been in the mouse model business since 1952 , are also spreading transgenic mice throughout India through a distribution agreement made earlier this month with Vivo Bio Tech, who gained rights to breed and distribute select Taconic mouse and rat models there. (genengnews.com)
  • Researchers soon learned that, by selectively breeding rats or mice with certain addiction traits, they could generate lines of animals with very specific addiction profiles. (utah.edu)
  • Many animals, especially mice, are greatly expanding our understanding of the complex disease of addiction. (utah.edu)
  • Models using species from mice to nonhuman primates have been used to evaluate and characterize vaccines to protect against the disease and may ultimately yield safer, less expensive vaccines. (ingentaconnect.com)
  • Further studies on the mutant mice already prove the model to be very powerful. (news-medical.net)
  • Many studies have reported on the identification of 'essential genes' in mice, but the context of the experimental model, including genetic background and specific molecular details of the allele, may impact the influence of alleles on viability. (nature.com)
  • This time, a research group of immunology Laboratory of the Central Institute for Experimental Animals, Kawasaki City, and Keio University, School of Medicine has successfully developed a humanized mouse model using NOG-IL-2 Tg mice that support to develop and maintain human NK cells suitable for in vivo cell function studies. (prweb.com)
  • Our Genetically Engineered Animals Models and Services team creates the foundation of a successful study by helping you to select, customize and maintain the right mice for your research. (criver.com)
  • For this purpose, we use mice and rats as model organisms. (zi-mannheim.de)
  • Society will need to rethink whether it wants to allow various experiments on animals in light of the fact that the researchers are doing basic, not applied research, and hence the results will not make the drug supply safer and curing cancer in mice will not be synonymous with curing cancer in humans. (opposingviews.com)
  • These interventions have emerged from a sprawling literature of animal experiments-lab tests run on mice that have been injected with a bacterial endotoxin, scalded with hot water, or opened at the abdomen and relieved of a major portion of their blood supply. (slate.com)
  • Yet none of the drugs that seemed so promising in model mice worked out so well in practice. (slate.com)
  • Now, scientists have further characterized a mouse model that provides some insights into biological factors related to social deficits, by comparing mice that had their oxytocin receptor gene made inactive, using a specialized technique called genetic knockout, with unaltered mice. (elsevier.com)
  • Taconic designs, breeds, and validates knock-in mouse models for translational research, enabling researchers to analyze gene expression, identify regulatory elements, and model disease in humanized mice. (taconic.com)
  • Taconic Biosciences was the first vendor to utilize CRISPR in both mice and rats, and is the first commercial custom animal model developer to hold licenses from both the Broad Institute and the UC Berkeley . (taconic.com)
  • There are a wide variety of animal models used in drug discovery including, but not limited to Drosophila, C. elegans , mice, rats, rabbits, dogs, cats and non-human primates. (taconic.com)
  • In this Taconic Insight, the focus will be on mice as a model used in drug discovery, yet many of the statements about mice are applicable to other species. (taconic.com)
  • With the advent of genetically engineered models (GEM) in the latter part of the 20th century, mice and other species were modified to better reflect disease pathways or for use in high throughput screening. (taconic.com)
  • The use of genetically engineered models increased the rate of discovery over the last fifty years as reflected through the number of publications with mice 2 . (taconic.com)
  • Mice have many advantages over other model organisms. (taconic.com)
  • For these reasons and others 95% of all animal studies use mice. (taconic.com)
  • For further information on this subject see Vandamme 3 , which provides a nice overview of why mice are a good model of human disease. (taconic.com)
  • In this animal, the human APP transgene is under the control of the TetO promoter and can be turned off by feeding the mice doxycycline (see description of Tet-Off System ). (alzforum.org)
  • Through project-focused consultations, educational programs including extensive training opportunities, open lab meetings and workshops, and direct experimental support (e.g., providing protocols and novel model systems), the Core serves a key role in facilitating access to state-of-the-art genome editing approaches and experimental systems for research programs that focus on digestive diseases. (massgeneral.org)
  • However, genetic and environmental factors play a significant role in cardiovascular pathophysiology, making difficult to match a particular disease, with a single experimental model. (hindawi.com)
  • Also, in November, the Central Institute for Experimental Animals (CIEA) granted rights for Taconic to produce and distribute the BRG mouse. (genengnews.com)
  • The need for experimental tumor models to efficiently reproduce the pathology of human cancers has prompted researchers to attempt various approaches. (urotoday.com)
  • Here, we highlight the diversity of animal models and their unique advantages, discuss the use of animal models to profile lncRNA expression, evaluate experimental strategies to manipulate lncRNA function in vivo, and review the phenotypes attributable to lncRNAs. (jci.org)
  • Included in a service package is experimental design advice, assistance with IACUC animal protocol submission, assistance with writing descriptions of these tests in grant proposals and manuscripts, data analysis, and results interpretation. (scripps.edu)
  • This review will highlight important features of existing experimental animal models with emphasis on new developments. (cdc.gov)
  • Experimental animal models of diisocyanate occupational asthma have demonstrated an immunological basis for the disease. (cdc.gov)
  • When it comes to discussions of essential genes, the full context of the experimental models are often not adequately defined. (nature.com)
  • Experimental animal models of disease can provide the crucial link from human disease to translational research into new therapies. (frontiersin.org)
  • Scientists have been able to take advantage of these similarities in generating experimental and predictive models of human disease. (wikipedia.org)
  • Animal models can also be more broadly classified into four categories: 1) experimental, 2) spontaneous, 3) negative, 4) orphan. (wikipedia.org)
  • Experimental models are most common. (wikipedia.org)
  • Negative models essentially refer to control animals, which are useful for validating an experimental result. (wikipedia.org)
  • The development of this first mouse model provides chikungunya researchers with an experimental tool that sheds light on the pathophysiology of the infection, paving the way for future treatments and vaccine candidates against this emerging viral disease in vivo. (medindia.net)
  • Arenaviruses are enveloped, bipartite negative single-stranded RNA viruses that can cause a wide spectrum of disease in humans and experimental animals including hemorrhagic fever. (mdpi.com)
  • Conclusion: BBB disruption is greater at 24h than at 48h in an experimental SAH model. (thejns.org)
  • Since most current APP mouse models overexpress the transgene throughout life, they might miss the effects of experimental drugs, she said. (alzforum.org)
  • Animal models of adult-onset neurodegenerative diseases have enhanced the understanding of the molecular pathogenesis of Alzheimer's disease, Parkinson's disease, frontotemporal dementia, and amyotrophic lateral sclerosis. (nature.com)
  • Here we review the current state of rodent models for Alzheimer's disease, Parkinson's disease, frontotemporal dementia, and amyotrophic lateral sclerosis. (nature.com)
  • APP mouse models for Alzheimer's disease preclinical studies. (nature.com)
  • Single App knock-in mouse models of Alzheimer's disease. (nature.com)
  • Another key finding in the study was a decreased Neuroflux signal at a very young age in a rodent model of Alzheimer's disease. (eurekalert.org)
  • Now, animal research suggests long-term exposure to electromagnetic waves associated with cell phone use may actually protect against, and even reverse, Alzheimer's disease. (psychcentral.com)
  • Overall, these findings from Lei Zhang and co-workers from Beijing Tiantan Hospital Affiliated to Capital Medical University in China revealed that 7.0T high-feld nuclear magnetic resonance spectroscopy detected the lesions and functional changes in hippocampal neurons of Alzheimer's disease rats in vivo, allowing the possibility for assessing the success rate and grading of the animal model of Alzheimer's disease. (medindia.net)
  • Animal models of Alzheimer's disease have provided key insights into the disorder, but researchers agree they have limitations for studying human disease. (alzforum.org)
  • An ideal animal model offers an opportunity to understand molecular, genetic, and epigenetic factors that may lead to depression. (wikipedia.org)
  • By using animal models, the underlying molecular alterations and the causal relationship between genetic or environmental alterations and depression can be examined, which would afford a better insight into pathology of depression. (wikipedia.org)
  • Antidepressant screening tests, not like the models which can be defined as an [organism] or a particular state of an organism that reproduces aspects of human pathology, provide only an end-point behavioral or physiological measure designed to assess the effect of the genetic, pharmacological, or environmental manipulation. (wikipedia.org)
  • Develops novel genetic technologies and model systems aimed at investigating genes and pathways to yield insight into how human genomic variants affect the pathogenesis of IBD. (massgeneral.org)
  • The Genetic Animal Models Core provides emerging genetic technology and model systems that enable transformative investigation into the impact of human genetic variants associated with IBD, including infantile and early-onset IBD. (massgeneral.org)
  • The several rodent models used for in vivo evaluation for oral cancer employ chemical, transplantation and genetic (knockout and transgenic) induction methods. (nih.gov)
  • Humanized animal models have been developed through genetic modification to provide specific attributes that are genetically human. (genengnews.com)
  • Our global network of commercial breeding facilities, rigorous genetic standards, and core values of animal welfare, biosecurity, and the 3Rs uniquely position us to be an integral part of your biomedical research programs. (criver.com)
  • An animal model (short for animal disease model) is a living, non-human, often genetic-engineered animal used during the research and investigation of human disease, for the purpose of better understanding the disease process without the added risk of harming an actual human. (wikipedia.org)
  • Although scientific study of animals predates Charles Darwin by several hundred years, the primary justification for the use of animals in research is based on the evolutionary principle that all organisms share some degree of relatedness and genetic similarity due to common ancestry. (wikipedia.org)
  • We will present the success rate derived from the analysis and of over 100 independent genetic humanization projects using the two most common approaches, namely gene replacement and minigene insertion, and provide specific guidelines for generation of these preclinical models. (taconic.com)
  • In quantitative genetics, the term animal model is used to refer to statistical models in which phenotypic variance is compartmentalised into environmental, genetic and sometimes maternal effects. (phys.org)
  • Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. (nih.gov)
  • Affecting over a hundred million individuals worldwide, retinal diseases are among the leading causes of irreversible visual impairment and blindness, and appropriate study models, especially animal models, are essential to furthering our understanding of the etiology, pathology, and progression of these endemic diseases. (springer.com)
  • In Animal Models for Retinal Diseases , recognized experts in the field highlight valuable techniques as well as animal models for the prominent retinal diseases in order to aid in the evaluation, development, and improvement of therapeutic strategies. (springer.com)
  • Vital and easy to use, Animal Models for Retinal Diseases serves to support the important future research of ocular investigators, ophthalmologists, and neuroscientists currently delving into this fascinating field of study. (springer.com)
  • Several models have been developed to address cardiovascular complications, including atherothrombotic and cardiac diseases, and the same pathology have been successfully recreated in different species, including small and big animal models of disease. (hindawi.com)
  • Here we will describe models of atherothrombotic diseases, including expanding and occlusive animal models, as well as models of heart failure. (hindawi.com)
  • Given the wide range of models available, today it is possible to devise the best strategy, which may help us to find more efficient and reliable solutions against human cardiovascular diseases. (hindawi.com)
  • The development of animal models of cardiovascular disease (CVD), including cardiac and atherothrombotic diseases, has provided us today with important insights into the pathophysiology, and they were found to be essential tools to evaluate new therapeutic strategies to predict and to prevent these complications. (hindawi.com)
  • Here, we will summarize the most common models of cardiovascular diseases, including those implemented in both large and small animals, designed for helping to cover with more precision and to better understand every single aspect related to these human pathologies. (hindawi.com)
  • In particular, we will describe models of atherothrombotic diseases, including expanding abdominal aortic aneurysms (AAA), thoracic aneurysms, and occlusive atherosclerotic diseases, as well as models of heart failure. (hindawi.com)
  • Biologically and clinically relevant animal models are essential in investigation of the progression of diseases and the elaboration of diagnostic or therapeutic protocols. (nih.gov)
  • A primary focus of this core is to provide tests that allow investigators to make transitions from laboratory findings to clinical applications by enabling the modeling of human diseases and the development of medications and other treatment strategies. (scripps.edu)
  • In addition, our animal models can be used for translational clinical and preclinical studies into human diseases. (wur.nl)
  • To improve preparedness for emerging and re-emerging zoonoses, we have developed techniques for rapid detection of new and emerging pathogens in animals to prevent their spread to the public as well as rapid risk assessment of potential microbiological hazards to adequately control new and emerging diseases. (wur.nl)
  • The success of drug development for human diseases heavily depends on the suitability of the animal models applied. (wur.nl)
  • Finally, models of extra-hepatic biliary obstruction continue to provide important information about the pathogenesis of portal fibrosis and secondary biliary cirrhosis that occurs in PSC and other diseases with obstruction of bile flow. (mendeley.com)
  • Use of animal models provides important knowledge about pathological conditions that can eventually lead to the development of more effective clinical treatment of diseases in both humans and animals. (routledge.com)
  • Before we can study any treatments or vaccines or even just the disease itself, we have to establish that we have an animal model that exhibits the same type of diseases as it occurs in humans. (wired.com)
  • Although biological activity in an animal model does not ensure an effect in humans, many drugs, treatments and cures for human diseases are developed in part with the guidance of animal models. (wikipedia.org)
  • Orphan models refer to diseases for which there is no human analog and occur exclusively in the species studied. (wikipedia.org)
  • The increase in knowledge of the genomes of non-human primates and other mammals that are genetically close to humans is allowing the production of genetically engineered animal tissues, organs and even animal species which express human diseases, providing a more robust model of human diseases in an animal model. (wikipedia.org)
  • Purpose: To develop an automated pulmonary image analysis framework for infectious lung diseases in small animal models. (osti.gov)
  • The results of projects supported under this PA are expected to be improvement of laboratory animal welfare, improved long-term maintenance and preservation of laboratory animal models, and improved technologies for generation of animal models of human diseases. (nih.gov)
  • Reagents to diagnose and control laboratory animal diseases, including those of aquatic animals, are needed. (nih.gov)
  • Furthermore, as new animal models are developed for the study of human diseases, long-term culture methods and/or germ-line preservation of these models becomes critical. (nih.gov)
  • The use of animal models in research resulted in the advancement of knowledge for how diseases affect animals and humans. (taconic.com)
  • For the last 10years he has been directly involved in the development of several in vivo models that have included GI- and respiratory-associated infectious diseases, device-associated (biofilm) infections, and pharmacokinetic studies within multiple animal species. (smi-online.co.uk)
  • BOSTON (Feb. 1, 2017)--Oral administration of a cocktail of three viruses, all of which specifically kill cholera bacteria, prevents infection and cholera-like symptoms in animal model experiments, report scientists from Tufts University School of Medicine (TUSM) and the Sackler School of Graduate Biomedical Sciences at Tufts in Nature Communications on Feb. 1. (eurekalert.org)
  • In order to evaluate the potential for clinical translation of these advancements, careful preclinical testing in appropriate models is absolutely indispensable. (biomedcentral.com)
  • In pre-clinical animal experiments, radiation delivery is usually delivered with kV photon beams, in contrast to the MV beams used in clinical irradiation, because of the small size of the animals. (biomedcentral.com)
  • Current strategies rely on cell- and animal-based assays during preclinical and clinical stages of drug development. (opposingviews.com)
  • During the experiment, data from animals such as body temperature, clinical signs, behaviour or feed intake are captured using our validated electronic data capture system. (wur.nl)
  • Our model in calves shows age-dependent clinical symptoms similar to the ones observed in humans after hRSV infection. (wur.nl)
  • Due to the close resemblance of the clinical and histological picture of human psoriasis, the new disease-model is ideally suited to study in detail all aspects of pathogenesis. (news-medical.net)
  • We strongly believe that this model will be highly suitable for future pre-clinical studies ultimately aimed at understanding and curing this widespread disease. (news-medical.net)
  • The Trouble With Animal Models Why did human trials fail By Andrea Gawrylewski Related Articles Why sex matters in mouse models Trials and error On October 26, 2006, at the opening day of the Joint World Congress for Stroke in Cape Town, South Africa, disappointing news spread quickly among the attendees: The second Phase III clinical trial for NXY-059 had failed. (the-scientist.com)
  • All had reached Phase III clinical trials and failed miserably at doing what their animal model tests had suggested they would: stop the cascade of necrosis in the event of stroke, and protect the remaining viable brain cells. (the-scientist.com)
  • In 1998, Fisher flew from Boston to Germany to help a drug company, along with academics specializing in animal modeling, to examine two sets of clinical trial results for a new stroke treatment that had failed. (the-scientist.com)
  • Animal models allow for controlled environments in which disease mechanisms can be defined, without the clinical confounders of environmental and lifestyle factors. (frontiersin.org)
  • The researchers are already studying CLR01 in a mouse model of Parkinson's and say they hope this will lead to human clinical trials. (scienceblog.com)
  • The protocols established by the animal study, published January 16 in Science Translational Medicine (STM), set the stage for a first-in-human clinical trial testing the therapy in people with geographic atrophy, for which there is currently no treatment. (newswise.com)
  • The animal studies inform the processes for conducting a first-in-human clinical trial testing the treatment. (newswise.com)
  • Therefore, our goal is to develop specific therapeutic models for these constellations, initially in animal models, and later on the clinical level. (zi-mannheim.de)
  • The team analyzed three sets of regulatory guidance documents published by the U.S. Food and Drug Administration, the European Medicines Agency, and the American Society for Testing and Materials, which provide recommendations on how large animal studies should be performed and reported in order to streamline translation to clinical trials. (medicalnewstoday.com)
  • Studies were scored based on adherence to 24 categories extracted from the guidance documents, relating to set up and description of the model - such as animal age, gender, and weight, as well as study duration and lesion size - and to the methods used for determining successful outcomes - including tissue and immune response, and whether a follow-up MRI or clinical evaluation were performed. (medicalnewstoday.com)
  • http://www.ncrr.nih.gov The National Cancer Institute (NCI) is particularly interested in technologies that support the development of pre-clinical models for cancer-related research. (nih.gov)
  • Here we demonstrate that NCCM is capable of regenerating the degenerative disc in a pre-clinical animal model of DDD. (thejns.org)
  • Materials/Methods: We used a 26-gauge needle and image guidance to develop DDD in a pre-clinical rodent model and characterized the degenerative cascade from healthy through 10-weeks by analyzing the IVD NPs until 6-weeks post injury. (thejns.org)
  • Preclinical safety testing in a large brain, animal model is now complete, and a clinical trial is being designed to assess the feasibility in patients with movement disorders. (thejns.org)
  • This meant we could detect rabies infection in living animals before clinical signs of rabies were detected. (cdc.gov)
  • Early identification of drugs that will fail testing in higher level animal models or clinical trials, lowers the over-all cost of drug development. (taconic.com)
  • We will focus on the transition from in vitro activity to in vivo efficacy, the choice of the right animal model for proof of concept studies, provide examples of relevant animal models with supportive data and interpretation of results as it relates to the clinical condition. (smi-online.co.uk)
  • Mark holds a Masters of Science degree in molecular microbiology and immunology, and his research at the University of North Texas Health Science Center has primarily been focused on bacterial pathogenesis and pre-clinical drug evaluation within in vivo models. (smi-online.co.uk)
  • The Pre-Clinical Services group at the University of North Texas Health Science Center conducts studies utilizing established models of both acute and chronic bacterial infections in several different animal species. (smi-online.co.uk)
  • UNTHSC Pre-clinical Services together has over 33 years of pharmaceutical and specialized biotech experience in the performance of therapeutic efficacy models and drug discovery / development. (smi-online.co.uk)
  • Prior to this, he was Director of Drug Evaluation at Cumbre Pharmaceuticals Inc. His responsibilities included animal efficacy models, pharmacology and all pre-clinical microbiology research and development efforts focused on the discovery and development of new antimicrobial agents. (smi-online.co.uk)
  • Mark Pulse has primarily been focused on bacterial pathogenesis and pre-clinical drug evaluation within in vivo models. (smi-online.co.uk)
  • Animal models of depression are research tools used to investigate depression and action of antidepressants as a simulation to investigate the symptomatology and pathophysiology of depressive illness or used to screen novel antidepressants. (wikipedia.org)
  • Animal models in oral cancer research. (nih.gov)
  • Model organisms are vital for biological research," says Robert Miller, a deputy division director in the National Science Foundation's (NSF) Biological Sciences Directorate. (nsf.gov)
  • White-crowned sparrows work particularly well for such research because different subspecies produce distinctly different songs, making them ideal for research on animal communication. (nsf.gov)
  • Not only are animal models misleading for human response to drugs and disease, not only has society lost cures because of animal models, but the continued use robs more modern and fruitful methods of research of money that could be used for worthwhile research. (opposingviews.com)
  • The growth of the field of eating disorder research has led to a vast array of empirical articles, and the development of new animal models that can be used to study these disorders continues to stimulate new research. (springer.com)
  • This book details advances in animal models of eating disorders research of interests to psychiatrists and mental health professionals. (springer.com)
  • Taconic and Yecuris are coming together to provide the knowledge and materials necessary for scientists to increase human relevance in their drug and vaccine research by using models that contain human primary cells," said John Bial, president and CEO of Yecuris. (genengnews.com)
  • Animals are particularly valuable research tools because they allow scientists to conduct experiments that they could never perform on humans. (utah.edu)
  • To the right are several model organisms that have been used in addiction research. (utah.edu)
  • The Animal Models Core consists of two subdivisions, the Rodent Genetics Core and the Biobehavioral Research Core . (cedars-sinai.edu)
  • We provide comprehensive services for a variety of animal research projects on genetically modified rodents and animal behavior. (cedars-sinai.edu)
  • Scripps Research Animal Models Core Facility has been established to provide a wide range of in vivo tests to the Scripps Research community as well as to the greater San Diego research community and beyond. (scripps.edu)
  • We invest in research into the use of innovative sensor technology to allow real time monitoring of animal health and welfare like telemetric devices or video monitoring. (wur.nl)
  • Due to a strong collaboration within Wageningen University & Research, experts on animal nutrition, animal welfare and animal husbandry are available for consultancy. (wur.nl)
  • Please feel free to contact the experts of our contract research organization (CRO) if you have a question concerning animal models for animal health. (wur.nl)
  • Many animal models developed within Wageningen Bioveterinary Research (WBVR) provide insights into human health issues. (wur.nl)
  • Animal Models in Orthopaedic Research is a reference book of the major animal models used in the study of orthopaedic conditions and in the in vivo study of biomaterials. (routledge.com)
  • This book is the result of the editors' own quest for information about research methodology and the use of animal models in orthopaedic and biomaterial research. (routledge.com)
  • Modeling Neuropsychiatric Disorders in Laboratory Animals serves as a guide for students and basic investigators in the fields of behavioral sciences, psychology, neuroscience, psychiatry, and other professionals interested in the use of animal models in preclinical research related to human neuropsychiatric disorders. (elsevier.com)
  • Final sections discuss the future for the development, validation, and use of animal models in basic and preclinical research. (elsevier.com)
  • This book is aimed mainly at students (including young investigators beginning a career in preclinical research involving animal models). (elsevier.com)
  • Scientists at the Research Institute of Molecular Pathology in Vienna have developed the first true animal model for psoriasis and have been able to address the initial steps and possible causes of the disease. (news-medical.net)
  • Studying animals, though controversial, is highly convenient for infectious disease research. (wired.com)
  • Without an animal model that closely replicates what goes on in humans, there's potential for harm in a fast-moving pandemic response like the one mobilizing now, warns Jay Rappaport, the director of Tulane National Primate Research Center. (wired.com)
  • Research presented by Dr. Lynn Raymond, from the University of British Columbia, shows that blocking a specific class of glutamate receptors, called extrasynaptic NMDA receptors, can improve motor learning and coordination, and prevent cell death in animal models of Huntington disease. (medicalnewstoday.com)
  • Charles River is committed to providing you with high quality research animal models. (criver.com)
  • From genetically standard and disease specific models to surgically altered animals, you can trust us to be an integral part of your biomedical research programs. (criver.com)
  • Selecting the appropriate animal models for your studies is critical to the success of your research. (criver.com)
  • Learn how our animal model evaluation program can help you determine if one of our models is right for your research. (criver.com)
  • Who do I call if I have a technical question regarding research animal models? (criver.com)
  • Animal models representing specific taxonomic groups in the research and study of developmental processes are also referred to as model organisms. (wikipedia.org)
  • citation needed] Animal models serving in research may have an existing, inbred or induced disease or injury that is similar to a human condition. (wikipedia.org)
  • The zebrafish is a popular animal for research because it is easily manipulated genetically, develops rapidly and is transparent, making the measurement of biological processes easier. (scienceblog.com)
  • While creating various mouse strains for generating humanized mouse models, the research team developed a new NOG mouse sub-strain, NOG-hIL-2 expressing the human cytokine IL-2, which supports the proliferation of T-cells. (prweb.com)
  • Despite continuing debate over the ethics of using animal models in research, progress in the field has been phenomenal in recent times, and a whole host of models, particularly mouse models, have been developed. (brightkite.com)
  • Understanding the body's functions requires scientific discoveries from animal research, and because humans and animals share more than 250 common illnesses, testing on animals is extremely beneficial to humans. (brightkite.com)
  • For years, our customers have entrusted us with the breeding and housing of their priceless animal research models, because they know relying on us to manage and maintain their outsourced colonies allows them to focus on their research. (criver.com)
  • The model developed in this research provides a fine-scale picture of the dynamics of AAT risk in sub-humid areas of West Africa. (plos.org)
  • A major problem in gerontological research is finding appropriate vertebrate models for examining aging processes, both normal and disease states, as well as testing potential drugs and life-style changes that might beneficially alter these processes. (nova.edu)
  • The Research Group „Animal Models in Psychiatry" develops and establishes models for psychiatric disorders with translational research approaches, especially for affective disorders such as depression and anxiety, but also for schizophrenia and cognitive disorders. (zi-mannheim.de)
  • A key aspect of this endeavor is the scientific evaluation of stressors implemented in these animal models, which we analyze within the DFG-funded national Research Group FOR 2591 ( www.severity-assessment.de ). (zi-mannheim.de)
  • So-called model organisms have long been at the core of biomedical research, allowing scientists to study the ins and outs of human disorders in non-human subjects. (opposingviews.com)
  • Sive sees the need to adopt a new term to expand the language of biological research to encompass systems that, although not technically models, can still offer tremendous utility in studying the etiology of human disorders. (opposingviews.com)
  • Sive, an advocate of using animals in research, outlines this idea in an editorial in Disease Models & Mechanisms . (opposingviews.com)
  • Greek and Greek 2010) This is how animal-based research has historically been sold to society and, as I have often said, such claims are simply not true. (opposingviews.com)
  • But in the past two decades there has been little to no adherence to the recommendations published by U.S. and European regulatory agencies on the manner in which translational research is conducted and reported in large animal models used to study cartilage repair. (medicalnewstoday.com)
  • Research has been stymied by imperfect animal models of the disease, which are costly, take considerable time to develop, and fail to mimic the most lethal aspects of the illness. (scienceblog.com)
  • Design precise, translatable, genetically-engineered animal models for preclinical research and drug discovery. (taconic.com)
  • Use the latest CRISPR/Cas9 gene editing technology to generate precise, translatable research models with a 100% success rate. (taconic.com)
  • RESEARCH OBJECTIVES A large variety of animal models, both mammalian and nonmammalian, is currently used in research to improve human health. (nih.gov)
  • Cost-effective methods, reagents and equipment to improve animal health and to characterize, culture and preserve biomedically important organisms are critical needs for biomedical research. (nih.gov)
  • The National Center for Research Resources (NCRR) supports model systems that are important to a broad base of research areas that include the research interests of more than one NIH categorical or disease-based Institute or Center. (nih.gov)
  • I had come to graduate school with very little experience working with research animals. (fbresearch.org)
  • Research on MCMs can include using animal models to test their effectiveness. (cdc.gov)
  • The Foundation for Biomedical Research website has a table listing the animals behind top drugs and a comprehensive summary of how animal testing and research has advanced human health. (taconic.com)
  • The use of animals in biomedical research dates back to approximately the 6th-5th century BC with more prominent references in the writings of Aristotle, Diocles, Praxagoras in the 4th century BC and Erasistratus and Herophilus in the 4th-3rd century BC 1 . (taconic.com)
  • He uses his 33 years of experience and expertise in infectious disease research to direct the evaluations of antibacterial agents, including established models of both acute and chronic bacterial infections in several different animal species as well as pharmacokinetic studies and HPLC or LCMS analysis in collaboration with large pharmaceutical companies, the biotech industry as well as academia. (smi-online.co.uk)
  • Again, depression is a heterogeneous disorder and its many symptoms are hard to be produced in laboratory animals. (wikipedia.org)
  • Preclinical radiation biology has become increasingly sophisticated due to the implementation of advanced small animal image guided radiation platforms into laboratory investigation. (biomedcentral.com)
  • We have a broad portfolio of animal models for various pathogens, which can be supported with extensive laboratory analyses. (wur.nl)
  • The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals. (ingentaconnect.com)
  • The highest-profile vaccine and treatment trials done on animals (including tests of the antiviral drug remdesivir) have been conducted only in Rhesus macaques, one of the most plentiful species of laboratory monkeys. (wired.com)
  • It's illegal to deliberately infect human volunteers ( though this may change if health authorities allow challenge trials ), but laboratory animals are easy to isolate and observe, and they can be subjected to invasive procedures and tissue sampling. (wired.com)
  • These refer to models of disease that resemble human conditions in phenotype or response to treatment but are induced artificially in the laboratory. (wikipedia.org)
  • For instance, behavioral analogues of anxiety or pain in laboratory animals can be used to screen and test new drugs for the treatment of these conditions in humans. (wikipedia.org)
  • Now, Cold Spring Harbor Laboratory (CSHL) scientists have developed a new method to rapidly create much better mouse models for metastatic prostate cancer. (scienceblog.com)
  • Equipment and techniques for cost-effective husbandry of animal models in controlled environments are needed for a variety of aquatic and non-aquatic laboratory animals. (nih.gov)
  • All model organisms share a few common traits: they're inexpensive, easy to care for, grow quickly and are relatively simple creatures. (nsf.gov)
  • Beyond developing a more comprehensive understanding of Dravet syndrome and epilepsy as a whole, the mouse models developed by Kalume and his collaborators have the potential to serve as model organisms for studying epilepsy co-morbidities such as sleep disorders and cognitive dysfunction. (seattlechildrens.org)
  • Many scientists who work on model organisms, including both of us, have been known to contrive a connection to human disease to boost a grant or paper. (opposingviews.com)
  • This new journal is aimed at people who set out with an explicit goal to investigate human disease using model organisms. (opposingviews.com)
  • Few new drugs have made it to the clinic during the past 50 years, with many that perform well in preclinical animal models of asthma, failing in humans owing to lack of safety and efficacy. (opposingviews.com)
  • In the current study, a team comprised of Camilli, Minmin Yen, Ph.D., recent graduate of the Molecular Microbiology Program at the Sackler School, and postdoctoral fellow Lynne Cairns, Ph.D., carried out a series of experiments in small animal models of cholera to test the efficacy of these phages as a preventative treatment. (eurekalert.org)
  • Therefore, efficacy testing of novel therapeutic and prophylactic strategies in relevant animal models is necessary. (mdpi.com)
  • Orthotopic tumour models are considered more clinically relevant and better predictive models of drug efficacy than standard subcutaneous models. (ugent.be)
  • Standard models for efficacy testing and the standard toxicology battery often fail to predict the value of inhalation therapy. (fraunhofer.de)
  • The FDA relies on data generated from animal models to assess efficacy and safety of new drug entities. (taconic.com)
  • Therefore, animal models of depression often display altered anxiety-related behavior. (wikipedia.org)
  • The text focuses on the rationale and theory of using animal behavior, both pathological and normal, as a tool for understanding the neural underpinnings of neuropsychiatric disorders. (elsevier.com)
  • This animal model also may be useful in evaluating the effectiveness of drugs, including vasopressin agonists, that may help improve social behavior in autism, schizophrenia, and other disorders," said Dr. John Krystal, Editor of Biological Psychiatry , the journal publishing these results. (elsevier.com)
  • Animal models observed in the sciences of psychology and sociology are often termed animal models of behavior . (phys.org)
  • In this chapter, we describe some of the most commonly used rodent models of alcohol intake and seeking as well as the methods used to identify the neural structures and circuits involved in alcohol-mediated behavior. (intechopen.com)
  • The corpus cavernosum after treatment with dutasteride or finasteride: A histomorphometric study in a benign prostatic hyperplasia rodent model. (urotoday.com)
  • The objective of this study was to investigate the structural changes in the penis using a benign prostatic hyperplasia (BPH) rodent model treated with dutasteride or finasteride. (urotoday.com)
  • For the JCI study, the team applied the radiotracer to monitor olfactory sensory neuron population dynamics in a rodent model, using PET to measure its uptake across the animals' lifespan, including during age-related neurodegeneration. (eurekalert.org)
  • Taconic is the most experienced rodent model design company in the industry, with a sixty-five year record of consistent quality and innovation. (taconic.com)
  • Although none of the models perfectly mimics the disease process in humans, each opens a window onto an important aspect of the pathology of the disease. (ingentaconnect.com)
  • Numerous routinely assessed multifactor characters in domestic animals rely on metabolic pathways likely to be implied in human multifactor pathology determinism. (innovations-report.com)
  • The study offered new insights into how form drives function in animal limbs, and shed slight on both the fossil record and prehistoric life on Earth. (nsf.gov)
  • The expanded use of various types of rodent models has produced some advances in the study of ED, and neurophysiological studies using various animal models have provided important insights into human sexual dysfunction. (urotoday.com)
  • Animal models can contribute insights into the pathogenesis, shedding and spreading of zoonotic agents. (wur.nl)
  • Since the aetiopathogenesis of primary sclerosing cholangitis (PSC) in humans remains undefined, investigators have studied a variety of animal models to gain insights into immunopathogenetic mechanisms associated with obliterative fibrous cholangitis of intra- and extrahepatic bile ducts. (mendeley.com)
  • Thus, understanding how neural circuitries are altered in animal models of ASDs may provide insights into the etiology of this disorder. (autismspeaks.org)
  • This study may provide insights into the neurobiology of autism, as well as help to develop a general and efficient strategy for relating genes to neurological dysfunction in rodent models of autism. (autismspeaks.org)
  • Andrew Wilson The suitability of the use of animal models and SiRNA Technologies in autosomal dominantly inherited neurodegenerative disease Dr P Martin Biomedical Science Abstract: The treatment of dominantly inherited neurodegenerative disease has been not feasible until recent discovers of gene therapy. (bartleby.com)
  • And when researchers step outside the traditional model organism box, they often seek new approaches and ask new questions. (nsf.gov)
  • Authoritative and practical, Animal Models of Eating Disorders aims to aid researchers in the use of animal models to assist in their investigation and characterization of the behaviors and neurochemical alterations associated with these devastating disorders. (springer.com)
  • Today, researchers are still studying some of these animal lines and strains. (utah.edu)
  • This similarity makes animals a convenient tool for researchers who study addiction. (utah.edu)
  • So when researchers discover a gene in a model organism that plays a role in addiction, they can then identify the counterpart gene in humans by searching a DNA database for similar sequences. (utah.edu)
  • The use of animal models allows researchers to investigate disease states in ways which would be inaccessible in a human patient, performing procedures on the non-human animal that imply a level of harm that would not be considered ethical to inflict on a human. (wikipedia.org)
  • The researchers next tried their tweezers in a living animal, the zebrafish, a tropical freshwater fish commonly found in aquariums. (scienceblog.com)
  • Using a transgenic zebrafish model for Parkinson's disease, the researchers added CLR01 and used fluorescent proteins to track the tweezer's effect on the aggregations. (scienceblog.com)
  • Genome Editing and Animal Models Core (GEAM), formerly Transgenic Animal Facility, was established in 1988 and has a long history of providing UW Madison researchers access to the latest technology for generating transgenic and gene targeted animals at a reasonable cost. (wisc.edu)
  • Researchers affiliated with the Kawasaki INnovation Gateway at SKYFRONT, have successfully developed a humanized mouse model showing that so-called NK cells that directly attacking tumors, can survive and maintain function in vivo. (prweb.com)
  • To overcome the difficulty of organising and accessing the large amounts of information on the various models, a large consortium of researchers set up a searchable database - the MUGEN Mouse Database (MMdb) (Aidinis et al. (brightkite.com)
  • The first animal model of the chikungunya virus (CHIKV), linked with large-scale epidemics that spread to Italy and India in 2007 has been developed by Researchers at the Institut Pasteur and INSERM. (medindia.net)
  • With this model, the researchers show how after an initial phase of viral replication in the liver, the infection extends to the joints, muscles and skin where the symptoms materialize in humans. (medindia.net)
  • Newswise - Using a novel patient-specific stem cell-based therapy, researchers at the National Eye Institute (NEI) prevented blindness in animal models of geographic atrophy, the advanced "dry" form of age-related macular degeneration (AMD), which is a leading cause of vision loss among people age 65 and older. (newswise.com)
  • The team evaluated 114 large animal studies - specifically cartilage repair in horses, sheep, pigs, dogs, and goats - published over the past two decades to determine whether researchers were conducting and reporting on all of the data points recommended in these guidelines. (medicalnewstoday.com)
  • instead, it serves as a model organism of powerhouse proportions. (nsf.gov)
  • A further feature of Kalume's mouse model that makes it ideal as a model organism for Dravet syndrome is that seizures are reliably triggered following acute increases in body temperature. (seattlechildrens.org)
  • The model predicts that water loss scales to gas exchange with an exponent of 1 and that the amount of water lost per unit of gas exchanged depends on several factors: the surface temperature of the respiratory system near the outside of the organism, the gas consumed (oxygen or carbon dioxide), the steepness of the gradients for gas and vapor, and the transport mode (convective or diffusive). (pnas.org)
  • Typically, all factors that limit an organism are not measured and included in statistical models used to investigate relationships with their environment. (usgs.gov)
  • Toward a better understanding of the molecular pathogenesis of human OS, several genetically modified OS mouse models have been developed and will be reviewed here. (frontiersin.org)
  • We offer more insight into the epidemiology, transmission and pathogenesis of zoonoses in animal and human cases. (wur.nl)
  • Future studies in either existing or new animal models should advance our understanding of the pathogenesis of PSC, the major prerequisite for the development of effective therapies. (mendeley.com)
  • In recent years a variety of in vivo models have been developed to elucidate the function of specific podocyte proteins and their role in the pathogenesis of proteinuria and glomerulosclerosis. (nih.gov)
  • Recent progress using animal models has been instrumental in furthering current understanding of the involvement of the immune system in disease pathogenesis. (cdc.gov)
  • This review will summarize our understanding of AAV pathogenesis as has been gleaned from currently available animal models, as well as address their strengths and limitations. (frontiersin.org)
  • An appropriate animal model of human depression should fulfill the following criteria as much as possible: strong phenomenological similarities and similar pathophysiology (face validity), comparable etiology (construct validity), and common treatment (predictive validity). (wikipedia.org)
  • The best models of disease are similar in etiology (mechanism of cause) and phenotype (signs and symptoms) to the human equivalent. (wikipedia.org)
  • In order to serve as a useful model, a modeled disease must be similar in etiology (mechanism of cause) and function to the human equivalent. (phys.org)
  • The use of animal models have contributed to increase our knowledge, providing new approaches focused to improve the diagnostic and the treatment of these pathologies. (hindawi.com)
  • These approaches perfectly fit our mission to contribute to welfare and prosperity by safeguarding animal and public health. (wur.nl)
  • A wide variety of modeling approaches are reconciled in the book using a consistent notation. (routledge.com)
  • Connections among approaches are highlighted to allow the reader to form a broader view of animal movement analysis and its associations with traditional spatial and temporal statistical modeling. (routledge.com)
  • In addition to thorough descriptions of animal movement models, differences and connections are also emphasized to provide a broader perspective of approaches. (routledge.com)
  • So there's hope that our model provides a fast and faithful test-bed for developing new approaches to cure the type of prostate cancer that today is incurable. (scienceblog.com)
  • Mouse models have proved to be useful to study development and progression of atherosclerotic lesion, and several reviews have extensively discussed the different available models [ 1 - 3 ]. (hindawi.com)
  • The reasons animal models cannot predict human response to drugs and disease are to be found in a study of evolutionary biology and complex systems. (opposingviews.com)
  • So scientists commonly study a variety of animals to learn about different aspects of human biology, including the reward pathway and addiction. (utah.edu)
  • This model is very suitable to study the effects of microbiota management to control C. difficile infections. (wur.nl)
  • A variety of animal species have been used to study both the acute and chronic forms of the disease. (ingentaconnect.com)
  • The study of animal movement has always been a key element in ecological science, because it is inherently linked to critical processes that scale from individuals to populations and communities to ecosystems. (routledge.com)
  • The book serves as a comprehensive reference for the types of statistical models used to study individual-based animal movement. (routledge.com)
  • It's an initial study, a few animals. (wired.com)
  • This study aimed to characterise two animal models of knee OA with particular respect to osteochondral and synovial angiogenesis. (nih.gov)
  • Full text of the study, "Cannabidiol exerts anti-convulsant effects in animal models of temporal lobe and partial seizures," appears online in Seizure: The Journal of the British Epilepsy Association. (norml.org)
  • In the present study, Dr. Xiong will examine neural connectivity in a mouse model of autism. (autismspeaks.org)
  • Comprehensive study of these models has yielded vital evidence for the concept that autoimmunity to joint-specific antigens can lead to arthritis.The. (brightkite.com)
  • The model also allowed the investigators to study the mother-to-child transmission of the virus. (medindia.net)
  • Bharti was the lead investigator for the animal-model study published in STM. (newswise.com)
  • Given this divergence, you might expect that scientists who study acute inflammation might look at other animals instead. (slate.com)
  • Philadelphia, PA - 5 May 2011 - The use of animal models to study human disease is essential to help advance our understanding of disease and to develop new therapeutic treatments. (elsevier.com)
  • The most widely used mouse models for prostate cancer rarely develop tumors that metastasize, making it almost impossible to study the terminal, lethal events in cancer progression. (scienceblog.com)
  • The animal study endpoint is clearly related to the desired benefit in humans, generally the enhancement of survival or prevention of major morbidity. (taconic.com)
  • A 2000 study found that animal models predicted human toxicity in 71% of cases, with 63% for nonrodents alone and 43% for rodents alone. (phys.org)
  • Use the models as dissection-free explorations, pre-dissection study tools, or summative assessments for comparative anatomy. (carolina.com)
  • Therefore, with our model the severity of the infection can be qualified and quantified by using different read out parameters. (wur.nl)
  • Recently, a Clostridium difficile infection model was developed in pigs that induces a dysbiosis in pigs. (wur.nl)
  • With both versions deleted, and therefore no ability to produce the protein, they constitute a model for the severe forms of the infection. (medindia.net)
  • Animals were given an oral dose of a cocktail containing all three phages, at time points ranging from three to 24 hours before infection with a standardized amount of V. cholerae bacteria. (eurekalert.org)
  • A preventative dose of the phage cocktail eliminated V. cholerae in the small intestines of over half of treated animals when given three hours before infection. (eurekalert.org)
  • In remaining animals, and for those treated up to 24 hours before infection, bacteria numbers were reduced 500-fold or more on average, compared to untreated controls. (eurekalert.org)
  • This article reviews the current arenavirus animal models and prophylactic and therapeutic strategies under development to treat arenavirus infection. (mdpi.com)
  • The tsetse apparent density and their infection rate were separately estimated and subsequently combined to derive the EIR using a "one layer-one model" approach. (plos.org)
  • Some pathogens, like Rabies lyssavirus (RABV), cause few signs of infection before death, which makes it hard to know if test animals survive because of effective MCM treatment, or because they were never infected. (cdc.gov)
  • Infection models or protocols other than those described herein can also be established or adapted as required to meet the more specific needs of interested Sponsors. (smi-online.co.uk)
  • Vivian Siegel, editor of Disease Models & Mechanisms , encouraged Sive to share it with the scientific community at large. (opposingviews.com)
  • Furthermore, relevant disease models like asthma and COPD were shortly introduced. (fraunhofer.de)
  • Handbook: Animal Models of Human Disease. (springer.com)
  • Bendele AM, McComb J, Gould T, et al (1999) Animal models of arthritis: relevance to human disease. (springer.com)
  • Nevertheless, our understanding of these disorders and the development of mechanistically designed therapeutics can still benefit from more rigorous use of the models and from generation of animals that more faithfully recapitulate human disease. (nature.com)
  • An animal model for a human disease can never exactly reproduce the complex disease traits in humans. (wur.nl)
  • We have previously described angiogenesis at the osteochondral junction and in synovium of knees from patients with osteoarthritis (OA), but little is known about how closely animal models of OA resemble human disease with respect to vascular growth. (nih.gov)
  • Predictive models are similar to a particular human disease in only a couple of aspects. (wikipedia.org)
  • The failure to translate promising drug candidates from animal models to humans has led to questions about the utility of in vivo studies and to demand for more predictive models and tools based on the latest technologies. (opposingviews.com)
  • Bendele AM (2001) Animal models of osteoarthritis. (springer.com)
  • Bendele AM (2002) Animal models of osteoarthritis in an era of molecular biology. (springer.com)
  • Brandt KD, Braunstein EM, Visco DM, et al (1991) Anterior (cranial) cruciate ligament transection in the dog: a bona fide model of osteoarthritis, not merely of cartilage injury and repair. (springer.com)
  • Brandt KD (2002) Animal models of osteoarthritis. (springer.com)
  • Brewster M, Lewis EJ, Wilson KL, et al (1998) Ro 32-3555,an orally active collagenase selective inhibitor,prevents structural damage in the STR/ORT mouse model of osteoarthritis. (springer.com)
  • Caterson B, Hughes C, Johnstone B, et al (1992) Immunological markers of cartilage proteoglycan metabolism in animal and human osteoarthritis. (springer.com)
  • Colombo C, Butler M, O'Byrne E, et al (1983) A new model of osteoarthritis in rabbits. (springer.com)
  • Connor JR, LePage C, Swift BA, et al (2005) Effects of an orally administered cathepsin K inhibitor (SB-553484) on the beagle dog medial meniscectomy model of osteoarthritis. (springer.com)
  • Animal models have proved to be of considerable importance in elucidating mechanisms underlying joint damage in osteoarthritis (OA) and providing proof of concept in the development of pharmacologic and biologic agents that may modify structural damage in the OA joint. (iospress.com)
  • You can think of animals as the product of a long history of experiments in nature," says Sandy Kawano, a postdoctoral researcher at the NSF-funded National Institute for Mathematical and Biological Synthesis (NIMBIoS). (nsf.gov)
  • Animal models of disease can be spontaneous (naturally occurring in animals), or be induced by physical, chemical or biological means. (phys.org)
  • The battles within each species have been unique, and every animal has a different arsenal of defenses. (wired.com)
  • Model predictions were largely confirmed by data on 202 species in five taxa-insects, birds, bird eggs, mammals, and plants-spanning nine orders of magnitude in rate of gas exchange. (pnas.org)
  • The effect is demonstrated in more than one animal species expected to react with a response predictive for humans, unless the effect is demonstrated in a single animal species that represents a sufficiently well-characterized animal model for predicting the response in humans. (taconic.com)
  • He also has experience with survival surgery in multiple animal species, including USDA species. (smi-online.co.uk)
  • AbstractAnimal models of autoimmune disease have been of vital importance in the advancement of our understanding of central pathological processes that underlie disease causation. (brightkite.com)
  • Methods: The authors describe a novel pathological lung and airway segmentation method for small animals. (osti.gov)
  • Investigators at the University of Reading, School of Pharmacy, in the United Kingdom assessed the anticonvulsant activity of CBD (administered in 1, 10, and 100mg/kg doses) in two established rodent seizure models, the acute pilocarpine model of temporal lobe seizure and the penicillin model of partial seizure. (norml.org)
  • At Penn Vet ​PSC-CORL, we have extensive experience with in vivo evaluation of biocompatibility and bioperformance of novel materials in acute and chronic animal models. (upenn.edu)
  • Models of toxic, infectious or intra-luminal injury of the biliary tract also exhibit focal biliary sclerosis mediated by inflammation and cytokines. (mendeley.com)
  • His expertise encompasses the development and evaluation of animal models of infectious disease as well as pharmacokinetic and pharmacodynamic analysis. (smi-online.co.uk)
  • Since olfactory sensory neurons regenerate throughout life, even in humans, the investigators were able to measure neuron regeneration in specific animal models. (eurekalert.org)
  • It is difficult to develop an animal model that perfectly reproduces the symptoms of depression in patients. (wikipedia.org)
  • But animals with more severe symptoms make it easier to measure the effect of interventions, like vaccines or antiviral drugs. (wired.com)
  • Dr. Raymond and her team were able, by using a drug that selectively blocks extra-synaptic NMDARs early, before the appearance of any symptoms, to delay the onset of Huntington-like symptoms in a mouse model of the disease. (medicalnewstoday.com)
  • Dr. Kalume's team and University of Washington collaborators have developed a mouse model of Dravet syndrome that closely mirrors the primary symptoms and co-morbidities expressed in human patients. (seattlechildrens.org)
  • Homologous animals have the same causes, symptoms and treatment options as would humans who have the same disease. (wikipedia.org)
  • Isomorphic animals share the same symptoms and treatments, only. (wikipedia.org)
  • While no animal model can be expected to replicate the full complexity of the human behavioral autistic phenotype, the OTR -/- mouse may really help to understand the co-occurrence of these symptoms as a syndrome," explained Dr. Bice Chini, author and senior researcher of CNR - Institute of Neuroscience, Milano. (elsevier.com)
  • To complement in vivo studies, technical support relevant to in vitro techniques such as organoid and primary cell models are available. (massgeneral.org)
  • David Luther studies a more modern phenomenon: how animals adapt to urban environments. (nsf.gov)
  • Never mind that animal studies give results like the above, people with a vested interest will still set up the old false dichotomy of your dog or your child . (opposingviews.com)
  • Promising initial studies using animal models demonstrated that lncRNAs influence a diverse number of phenotypes, ranging from subtle dysmorphia to viability. (jci.org)
  • Despite a limited number of studies leveraging animal models, lncRNAs are already recognized as a notable class of molecules with important implications for health and disease. (jci.org)
  • However, it would also be useful for psychiatrists to better understand and interpret preclinical studies involving animal models. (elsevier.com)
  • These studies really need to be done first in a model that closely resembles what happens in humans," Rappaport says. (wired.com)
  • There's no doubt about the absence of an effect [of NYX-059], and that called into question the many other studies in stroke, and how good are the animal models? (the-scientist.com)
  • Results from animal studies of AAV have played a crucial role in enhancing our understanding of disease mechanisms, and have provided direction toward newer targeted therapies. (frontiersin.org)
  • Studies of global and conditional knock out animals showed that sleep disorders in Dravet correlate with dysfunction of GABAergic interneurons in the reticular nucleus of the thalamus (RNT), whereas seizures are linked to functional impairments of GABAergic interneurons in the hippocampus. (seattlechildrens.org)
  • Additionally, through our collaboration with genOway, we offer knockout mouse models for use in in vivo studies. (criver.com)
  • Ten weeks after the human iPSC-derived RPE patches were implanted in the animals' retinas, imaging studies confirmed that the lab-made cells had integrated within the animal retina. (newswise.com)
  • It is our intention to use the killifish as a model to pursue gerontological studies on learning and memory. (nova.edu)
  • Results showed that there was little to no impact of the publication of the guidance documents on the level of adherence of the large animal studies reviewed. (medicalnewstoday.com)
  • However when we completed our analysis, we were surprised to find that for the large animal studies we examined, most did not follow the guidelines to any great extent. (medicalnewstoday.com)
  • Results: 133 CT scans were collected from four different studies encompassing a wide spectrum of pulmonary abnormalities pertaining to two commonly used small animal models (ferret and rabbit). (osti.gov)
  • While many previous studies report nanobodies active against SARS-CoV-2 in vitro, none have been evaluated via animal models' intranasal administration. (news-medical.net)
  • This guest post was written by Sloka Iyengar, Ph.D., a neuroscientist who studies animal models of epilepsy. (fbresearch.org)
  • Each model offers advantages and disadvantages, making them useful in certain types of studies or phases of drug discovery . (taconic.com)
  • The lower cost of developing, breeding and conducting studies in mouse models facilitates their use in high-throughput screening. (taconic.com)
  • Two of the studies were chosen for discussion at an SfN press conference on AD, while others were part of nanosymposia on animal models and Aβ (see Part 1 of this series for other press conference coverage). (alzforum.org)
  • These test conditions are often termed as animal models of disease. (wikipedia.org)
  • For this reason, the development and characterization of animal models are germane to further understanding of diisocyanate occupational asthma and to identify avenues for therapeutic intervention. (cdc.gov)
  • An animal model is a proxy that scientists find-or create using gene editing-that experiences a particular disease the way humans do. (wired.com)
  • To create the model, called RapidCaP, scientists surgically deliver gene mutations directly into the prostate. (scienceblog.com)
  • The scientists first used the model to test what happened when they shut down APP production late in life, after plaques had formed (see ARF related news story ). (alzforum.org)
  • Therefore, in vivo models showing that NK cells survive and maintain function long-term are eagerly desired. (prweb.com)
  • The US Food and Drug Administration (FDA)[3] and European Innovative Medicines Initiative (IMI)[4] have acknowledged the limitations of animal models as a major bottleneck in the development of efficacious and safe medicines across many therapeutic areas, including asthma. (opposingviews.com)
  • This small animal model offers a quick, inexpensive, and simple method for screening therapeutic agents that alter infarct size. (biomedsearch.com)
  • The demonstration of diisocyanate occupational asthma in a murine model after sub-chronic inhalation exposure at relevant exposure levels should provide opportunities for more accurate risk assessment data. (cdc.gov)
  • This thesis encompasses three independent experiments looking at bystander and bystander-like responses in both plant and animal models. (uleth.ca)
  • Opponents of animal testing advocate alternative means such as using computer models in experiments. (brightkite.com)
  • Rapid improvements in biotelemetry data collection and processing technology have given rise to a variety of statistical methods for characterizing animal movement. (routledge.com)
  • A more efficient conditional mouse model of Dravet syndrome: Implications for epigenetic selection and sex-dependent behaviors J Neurosci Methods . (seattlechildrens.org)
  • Animal Movement is an essential reference for wildlife biologists, quantitative ecologists, and statisticians who seek a deeper understanding of modern animal movement models. (routledge.com)
  • Quantitative and Functional Requirements for Bioluminescent Cancer Models. (ugent.be)
  • A mouse model can predict the outcome of Influenza vaccination in humans. (wur.nl)
  • Kalume F , Oakley JC, Westenbroek RE, Gile J, de la Iglesia HO, Scheuer T, Catterall WA, Sleep impairment and reduced interneuron excitability in a mouse model of Dravet Syndrome , Neurobiol Dis . (seattlechildrens.org)
  • In work published today in Cancer Discovery , a CSHL team led by Associate Professor Lloyd Trotman report that they have developed a new mouse model that does generate metastases from primary prostate tumors. (scienceblog.com)
  • All iw43d models built to scale-extremely efficient mesh-fully texture mapped-all materials included-movable parts that can be articulated-easily adapt to game engines. (turbosquid.com)
  • intervertebral disc (IVD) in animal models induces structural damage and leads to IVD degeneration over time. (thejns.org)
  • Instead of determining toxicity of xenobiotics in test animals by using the 'dose response' approach, I would like to bring up the concept of 'response to dose' for discussion. (bio.net)
  • The modified animals have a range of human attributes passed on from the human cells including human metabolism and toxicity profiles, and the ability to become infected with human pathogens and viruses like malaria and hepatitis. (genengnews.com)
  • To implement this approach Michael Festing has repeatedly proposed the use of multiple inbred strains - without increasing the total number of animals in the bioassay - to mimic some of the diversity of genotypes and sensitivities to induction of toxic endpoints within human populations. (bio.net)
  • Whereas previous models were only able to reproduce the skin lesions, the new strain also develops psoriatic arthritis. (news-medical.net)
  • Each custom model design project develops along an agile framework, letting you reassess and retarget your model fluidly as new data becomes available. (taconic.com)
  • This article discusses risk factors that may play a role in age-related LUT dysfunction and presents available data comparing structural and functional changes that occur with aging in the bladder of humans and animal models. (urotoday.com)
  • In particular, knockout and transgenic mouse models for atherosclerosis have been instrumental in understanding the molecular and cellular mechanisms involved in atherogenesis, and in evaluating the effectiveness of new and existing atherosclerotic drugs [ 4 ]. (hindawi.com)
  • This would be an improvement over the MTD which, in many if not most cases, overwhelms the normal defensive processing mechanisms in both humans and test animals - and would make extrapolation to human populations exposed to far lower dose levels more meaningful. (bio.net)
  • Animal models of proteinuria and nephrotic syndrome are essential tools for studying the mechanisms of action of abnormalities in individual components of the podocyte and glomerular basement membrane. (nih.gov)
  • At the Society for Neuroscience 2012 annual meeting, held 13-17 October in New Orleans, Louisiana, several presentations raised questions about current animal models and their relationships to disease mechanisms. (alzforum.org)
  • Although cultured cells have facilitated investigations of lncRNA function at the molecular level, the use of animal models provides a rich context in which to investigate the phenotypic impact of these molecules. (jci.org)
  • The utility of animal models in predicting the response to an intervention with a drug or biologic agent in humans, however, can be established only after evidence is obtained of a positive effect of the agent in humans. (iospress.com)
  • However, a good animal model for translational medicine can contribute valuable information, like drug discovery or validation. (wur.nl)
  • We offer several models for translational medicine. (wur.nl)

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