AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesHealth Care
MitomycinMitomycinsAntibiotics, AntineoplasticNucleic Acid Synthesis InhibitorsPorfiromycinDicumarolAlkylating AgentsPterygiumTrabeculectomyFanconi AnemiaNAD(P)H Dehydrogenase (Quinone)AziridinesCisplatinConjunctivaVindesineAdministration, IntravesicalFluorouracilUltraviolet RaysFiltering SurgeryDNA DamageLysogenyBacteriophagesMutagensIntraoperative CareFanconi Anemia Complementation Group C ProteinFanconi Anemia Complementation Group ProteinsSister Chromatid ExchangeAntineoplastic Combined Chemotherapy ProtocolsAntimutagenic AgentsGlaucomaFanconi Anemia Complementation Group G ProteinOphthalmic SolutionsSOS Response (Genetics)BiotransformationPeplomycin
Mitomycin
An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
Mitomycins
A group of methylazirinopyrroloindolediones obtained from certain Streptomyces strains. They are very toxic antibiotics used as ANTINEOPLASTIC AGENTS in some solid tumors. PORFIROMYCIN and MITOMYCIN are the most useful members of the group.
Antibiotics, Antineoplastic
Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms.
Nucleic Acid Synthesis Inhibitors
Compounds that inhibit cell production of DNA or RNA.
Porfiromycin
Toxic antibiotic of the mitomycin group, obtained from MITOMYCIN and also from Streptomyces ardus and other species. It is proposed as an antineoplastic agent, with some antibiotic properties.
Dicumarol
An oral anticoagulant that interferes with the metabolism of vitamin K. It is also used in biochemical experiments as an inhibitor of reductases.
Alkylating Agents
Highly reactive chemicals that introduce alkyl radicals into biologically active molecules and thereby prevent their proper functioning. Many are used as antineoplastic agents, but most are very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. They have also been used as components in poison gases.
Pterygium
An abnormal triangular fold of membrane in the interpalpebral fissure, extending from the conjunctiva to the cornea, being immovably united to the cornea at its apex, firmly attached to the sclera throughout its middle portion, and merged with the conjunctiva at its base. (Dorland, 27th ed)
Trabeculectomy
Any surgical procedure for treatment of glaucoma by means of puncture or reshaping of the trabecular meshwork. It includes goniotomy, trabeculectomy, and laser perforation.
Fanconi Anemia
Congenital disorder affecting all bone marrow elements, resulting in ANEMIA; LEUKOPENIA; and THROMBOPENIA, and associated with cardiac, renal, and limb malformations as well as dermal pigmentary changes. Spontaneous CHROMOSOME BREAKAGE is a feature of this disease along with predisposition to LEUKEMIA. There are at least 7 complementation groups in Fanconi anemia: FANCA, FANCB, FANCC, FANCD1, FANCD2, FANCE, FANCF, FANCG, and FANCL. (from Online Mendelian Inheritance in Man, http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=227650, August 20, 2004)
NAD(P)H Dehydrogenase (Quinone)
A flavoprotein that reversibly catalyzes the oxidation of NADH or NADPH by various quinones and oxidation-reduction dyes. The enzyme is inhibited by dicoumarol, capsaicin, and caffeine.
Aziridines
Saturated azacyclopropane compounds. They include compounds with substitutions on CARBON or NITROGEN atoms.
Cisplatin
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
Conjunctiva
The mucous membrane that covers the posterior surface of the eyelids and the anterior pericorneal surface of the eyeball.
Vindesine
Vinblastine derivative with antineoplastic activity against CANCER. Major side effects are myelosuppression and neurotoxicity. Vindesine is used extensively in chemotherapy protocols (ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS).
Administration, Intravesical
The instillation or other administration of drugs into the bladder, usually to treat local disease, including neoplasms.
Fluorouracil
A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
Ultraviolet Rays
That portion of the electromagnetic spectrum immediately below the visible range and extending into the x-ray frequencies. The longer wavelengths (near-UV or biotic or vital rays) are necessary for the endogenous synthesis of vitamin D and are also called antirachitic rays; the shorter, ionizing wavelengths (far-UV or abiotic or extravital rays) are viricidal, bactericidal, mutagenic, and carcinogenic and are used as disinfectants.
Filtering Surgery
A surgical procedure used in treatment of glaucoma in which an opening is created through which aqueous fluid may pass from the anterior chamber into a sac created beneath the conjunctiva, thus lowering the pressure within the eye. (Hoffman, Pocket Glossary of Ophthalmologic Terminology, 1989)
DNA Damage
Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.
Lysogeny
The phenomenon by which a temperate phage incorporates itself into the DNA of a bacterial host, establishing a kind of symbiotic relation between PROPHAGE and bacterium which results in the perpetuation of the prophage in all the descendants of the bacterium. Upon induction (VIRUS ACTIVATION) by various agents, such as ultraviolet radiation, the phage is released, which then becomes virulent and lyses the bacterium.
Bacteriophages
Viruses whose hosts are bacterial cells.
Mutagens
Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes.
Intraoperative Care
Patient care procedures performed during the operation that are ancillary to the actual surgery. It includes monitoring, fluid therapy, medication, transfusion, anesthesia, radiography, and laboratory tests.
Fanconi Anemia Complementation Group C Protein
A Fanconi anemia complementation group protein that regulates the activities of CYTOCHROME P450 REDUCTASE and GLUTATHIONE S-TRANSFERASE. It is found predominately in the CYTOPLASM, but moves to the CELL NUCLEUS in response to FANCE PROTEIN.
Fanconi Anemia Complementation Group Proteins
A diverse group of proteins whose genetic MUTATIONS have been associated with the chromosomal instability syndrome FANCONI ANEMIA. Many of these proteins play important roles in protecting CELLS against OXIDATIVE STRESS.
Sister Chromatid Exchange
An exchange of segments between the sister chromatids of a chromosome, either between the sister chromatids of a meiotic tetrad or between the sister chromatids of a duplicated somatic chromosome. Its frequency is increased by ultraviolet and ionizing radiation and other mutagenic agents and is particularly high in BLOOM SYNDROME.
Antineoplastic Combined Chemotherapy Protocols
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
Antimutagenic Agents
Agents that reduce the frequency or rate of spontaneous or induced mutations independently of the mechanism involved.
Glaucoma
An ocular disease, occurring in many forms, having as its primary characteristics an unstable or a sustained increase in the intraocular pressure which the eye cannot withstand without damage to its structure or impairment of its function. The consequences of the increased pressure may be manifested in a variety of symptoms, depending upon type and severity, such as excavation of the optic disk, hardness of the eyeball, corneal anesthesia, reduced visual acuity, seeing of colored halos around lights, disturbed dark adaptation, visual field defects, and headaches. (Dictionary of Visual Science, 4th ed)
Fanconi Anemia Complementation Group G Protein
A Fanconi anemia complementation group protein that undergoes PHOSPHORYLATION by CDC2 PROTEIN KINASE during MITOSIS. It forms a complex with other FANCONI ANEMIA PROTEINS and helps protect CELLS from DNA DAMAGE by genotoxic agents.
Ophthalmic Solutions
Sterile solutions that are intended for instillation into the eye. It does not include solutions for cleaning eyeglasses or CONTACT LENS SOLUTIONS.
SOS Response (Genetics)
An error-prone mechanism or set of functions for repairing damaged microbial DNA. SOS functions (a concept reputedly derived from the SOS of the international distress signal) are involved in DNA repair and mutagenesis, in cell division inhibition, in recovery of normal physiological conditions after DNA repair, and possibly in cell death when DNA damage is extensive.
Biotransformation
The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
Peplomycin
An antineoplastic agent derived from BLEOMYCIN.

Nuclear foci of mammalian recombination proteins are located at single-stranded DNA regions formed after DNA damage. (1/1595)

A sensitive and rapid in situ method was developed to visualize sites of single-stranded (ss) DNA in cultured cells and in experimental test animals. Anti-bromodeoxyuridine antibody recognizes the halogenated base analog incorporated into chromosomal DNA only when substituted DNA is in the single strand form. After treatment of cells with DNA-damaging agents or gamma irradiation, ssDNA molecules form nuclear foci in a dose-dependent manner within 60 min. The mammalian recombination protein Rad51 and the replication protein A then accumulate at sites of ssDNA and form foci, suggesting that these are sites of recombinational DNA repair.  (+info)

Potentiation of anti-cancer drug activity at low intratumoral pH induced by the mitochondrial inhibitor m-iodobenzylguanidine (MIBG) and its analogue benzylguanidine (BG). (2/1595)

Tumour-selective acidification is of potential interest for enhanced therapeutic gain of pH sensitive drugs. In this study, we investigated the feasibility of a tumour-selective reduction of the extracellular and intracellular pH and their effect on the tumour response of selected anti-cancer drugs. In an in vitro L1210 leukaemic cell model, we confirmed enhanced cytotoxicity of chlorambucil at low extracellular pH conditions. In contrast, the alkylating drugs melphalan and cisplatin, and bioreductive agents mitomycin C and its derivative EO9, required low intracellular pH conditions for enhanced activation. Furthermore, a strong and pH-independent synergism was observed between the pH-equilibrating drug nigericin and melphalan, of which the mechanism is unclear. In radiation-induced fibrosarcoma (RIF-1) tumour-bearing mice, the extracellular pH was reduced by the mitochondrial inhibitor m-iodobenzylguanidine (MIBG) or its analogue benzylguanidine (BG) plus glucose. To simultaneously reduce the intracellular pH, MIBG plus glucose were combined with the ionophore nigericin or the Na+/H+ exchanger inhibitor amiloride and the Na+-dependent HCO3-/Cl- exchanger inhibitor 4,4'-diisothiocyanostilbene-2,2'-disulphonic acid (DIDS). Biochemical studies confirmed an effective reduction of the extracellular pH to approximately 6.2, and anti-tumour responses to the interventions indicated a simultaneous reduction of the intracellular pH below 6.6 for at least 3 h. Combined reduction of extra- and intracellular tumour pH with melphalan increased the tumour regrowth time to 200% of the pretreatment volume from 5.7 +/- 0.6 days for melphalan alone to 8.1 +/- 0.7 days with pH manipulation (P < 0.05). Mitomycin C related tumour growth delay was enhanced by the combined interventions from 3.8 +/- 0.5 to 5.2 +/- 0.5 days (P < 0.05), but only in tumours of relatively large sizes. The interventions were non-toxic alone or in combination with the anti-cancer drugs and did not affect melphalan biodistribution. In conclusion, we have developed non-toxic interventions for sustained and selective reduction of extra- and intracellular tumour pH which potentiated the tumour responses to selected anti-cancer drugs.  (+info)

Adjuvant therapy with oral fluoropyrimidines as main chemotherapeutic agents after curative resection for colorectal cancer: individual patient data meta-analysis of randomized trials. (3/1595)

BACKGROUND: Oral 5-fluorouracil and its prodrugs (tegafur, carmofur) is now being studied for adjuvant chemotherapy of curatively resected colorectal cancers. To evaluate the effect of these oral fluoropyrimidines (o-FPs), an individual patient data (IPD) meta-analysis of randomized clinical trials was performed in Japan as an inter-trialist group study. METHODS: Data from the three clinical trials in which postoperative adjuvant therapy with o-FPs was compared with surgery alone in patients with colorectal cancer were sought. IPD from a total of 4960 patients with follow-up periods of at least 5 years were analyzed. RESULTS: The results of the meta-analysis on an 'intention to treat' basis demonstrated a significant benefit of o-FPs in terms of the disease-free survival (DFS) of the total patients [risk ratio (RR) 0.830, 95% confidence interval (CI) 0.742-0.929, P = 0.001]. o-FPs were also demonstrated to be effective for survival in rectal cancer (RR 0.857, 95% CI 0.734-0.999, P = 0.049) and in Dukes'C colorectal cancer (RR 0.828, 95% CI 0.711-0.965, P = 0.016). CONCLUSION: The results suggest the advantage of long term o-FPs, possibly with the injection of mitomycin C, for prognosis for curatively resected colorectal cancer patients.  (+info)

Genetic localization and molecular characterization of two key genes (mitAB) required for biosynthesis of the antitumor antibiotic mitomycin C. (4/1595)

Mitomycin C (MC) is an antitumor antibiotic derived biosynthetically from 3-amino-5-hydroxybenzoic acid (AHBA), D-glucosamine, and carbamoyl phosphate. A gene (mitA) involved in synthesis of AHBA has been identified and found to be linked to the MC resistance locus, mrd, in Streptomyces lavendulae. Nucleotide sequence analysis showed that mitA encodes a 388-amino-acid protein that has 71% identity (80% similarity) with the rifamycin AHBA synthase from Amycolatopsis mediterranei, as well as with two additional AHBA synthases from related ansamycin antibiotic-producing microorganisms. Gene disruption and site-directed mutagenesis of the S. lavendulae chromosomal copy of mitA completely blocked the production of MC. The function of mitA was confirmed by complementation of an S. lavendulae strain containing a K191A mutation in MitA with AHBA. A second gene (mitB) encoding a 272-amino-acid protein (related to a group of glycosyltransferases) was identified immediately downstream of mitA that upon disruption resulted in abrogation of MC synthesis. This work has localized a cluster of key genes that mediate assembly of the unique mitosane class of natural products.  (+info)

Phthalascidin, a synthetic antitumor agent with potency and mode of action comparable to ecteinascidin 743. (5/1595)

A series of totally synthetic molecules that are structurally related to the marine natural product ecteinascidin 743 (Et 743) has been prepared and evaluated as antitumor agents. The most active of these, phthalascidin, is very similar to Et 743 with regard to in vitro potency and mode of action across a variety of cell types. The antiproliferative activity of phthalascidin (IC50 = 0.1-1 nM) is greater than that of the agents Taxol, camptothecin, adriamycin, mitomycin C, cisplatin, bleomycin, and etoposide by 1-3 orders of magnitude, and the mechanism of action is clearly different from these currently used drugs. Phthalascidin and Et 743 induce DNA-protein cross-linking and, although they seem to interact with topoisomerase (topo) I (but not topo II), topo I may not be the primary protein target of these agents. Phthalascidin and Et 743 show undiminished potency in camptothecin- and etoposide-resistant cells. Phthalascidin is more readily synthesized and more stable than Et 743, which is currently undergoing clinical trials. The relationship of chemical structure and antitumor activity for this class of molecules has been clarified by this study.  (+info)

Molecular characterization and analysis of the biosynthetic gene cluster for the antitumor antibiotic mitomycin C from Streptomyces lavendulae NRRL 2564. (6/1595)

BACKGROUND: The mitomycins are natural products that contain a variety of functional groups, including aminobenzoquinone- and aziridine-ring systems. Mitomycin C (MC) was the first recognized bioreductive alkylating agent, and has been widely used clinically for antitumor therapy. Precursor-feeding studies showed that MC is derived from 3-amino-5-hydroxybenzoic acid (AHBA), D-glucosamine, L-methionine and carbamoyl phosphate. A genetically linked AHBA biosynthetic gene and MC resistance genes were identified previously in the MC producer Streptomyces lavendulae NRRL 2564. We set out to identify other genes involved in MC biosynthesis. RESULTS: A cluster of 47 genes spanning 55 kilobases of S. lavendulae DNA governs MC biosynthesis. Fourteen of 22 disruption mutants did not express or overexpressed MC. Seven gene products probably assemble the AHBA intermediate through a variant of the shikimate pathway. The gene encoding the first presumed enzyme in AHBA biosynthesis is not, however, linked within the MC cluster. Candidate genes for mitosane nucleus formation and functionalization were identified. A putative MC translocase was identified that comprises a novel drug-binding and export system, which confers cellular self-protection on S. lavendulae. Two regulatory genes were also identified. CONCLUSIONS: The overall architecture of the MC biosynthetic gene cluster in S. lavendulae has been determined. Targeted manipulation of a putative MC pathway regulator led to a substantial increase in drug production. The cloned genes should help elucidate the molecular basis for creation of the mitosane ring system, as well efforts to engineer the biosynthesis of novel natural products.  (+info)

Pre-operative chemotherapy in early stage resectable non-small-cell lung cancer: a randomized feasibility study justifying a multicentre phase III trial. (7/1595)

Surgical resection offers the best chance for cure for early stage non-small-cell lung cancer (NSCLC, stage I, II, IIIA), but the 5-year survival rates are only moderate, with systemic relapse being the major cause of death. Pre-operative (neo-adjuvant) chemotherapy has shown promise in small trials restricted to stage IIIA patients. We believe similar trials are now appropriate in all stages of operable lung cancer. A feasibility study was performed in 22 patients with early stage (IB, II, IIIA) resectable NSCLC; randomized to either three cycles of chemotherapy [mitomycin-C 8 mg m(-2), vinblastine 6 mg m(-2) and cisplatin 50 mg m(-2) (MVP)] followed by surgery (n = 11), or to surgery alone. Of 40 eligible patients, 22 agreed to participate (feasibility 55%) and all complied with the full treatment schedule. All symptomatic patients achieved either complete (50%) or partial (50%) relief of tumour-related symptoms with pre-operative chemotherapy. Fifty-five per cent achieved objective tumour response, and a further 27% minor tumour shrinkage; none had progressive disease. Partial pathological response was seen in 50%. No severe (WHO grade III-IV) toxicities occurred. No significant deterioration in quality of life was detected during chemotherapy. Pre-operative MVP chemotherapy is feasible in early stage NSCLC, and this study has now been initiated as a UK-wide Medical Research Council phase III trial.  (+info)

Stimulation of adult human bone marrow by factors secreted by fetal liver hematopoietic cells: in vitro evaluation using semisolid clonal assay system. (8/1595)

Fetal liver infusion (FLI) therapy has been used in various disorders, such as aplastic anemia, leukemia, metabolic disorders, etc., and has been shown to result in stimulation of autologous hematopoiesis in many cases. The aim of the present study was to elucidate the mechanism of stimulation of adult hematopoiesis by fetal liver hematopoietic cells (FLHC) and to identify the factors involved in the process using a clonal assay system in vitro. The effect of FLHC on the clonal growth of bone marrow cells was studied using a co-culture system consisting of mitomycin C-treated FLHC with 2 x 10(5) bone marrow (BM) mononuclear cells. It was observed that FLHC induced a two- to four-fold increase in the BM colony formation. A further increase in the number of FLHC did not, however, result in an equivalent fold increase in the colony formation, indicating that the number of cells in the BM population responsive to FLHC was perhaps the limiting factor. When the effect of fetal liver cell conditioned medium (FLCM) was examined in a similar fashion, it was observed that the FLCM showed a 1.5- to 4-fold increase in the colony formation when used at 1%-5% along with limiting amounts of growth factors. Higher concentrations of conditioned medium resulted in inhibitory responses. One of the principal factors responsible for the stimulatory activity of FLCM was shown to be transforming growth factor-beta1 (TGF-beta1), by a variety of experiments such as its quantitation in FLCM by enzyme-linked immunosorbent assay, antibody neutralization, and reconstruction experiments using purified TGF-beta1 and normal medium. In these reconstitution experiments, TGF-beta1 stimulated the colony formation when it was applied at 1-50 pg/ml, but at higher concentration it induced an inhibitory effect, mimicking the behavior earlier seen with FLCM. Our data strongly suggest that one of the mechanisms in stimulation of a recipient's hematopoiesis could be mediated by the action of TGF-beta1 secreted by infused FLHC and could provide a rational framework on which FLI therapy can be further evaluated.  (+info)

Mitomycin instillation medac - Slimming tea mustika ratu
The Dangers of Using Mitomycin-C The potent agent that has the power to banish haze may be able to make endothelial cells disappear, as well.. Mitomycin is FDA approved for the...Mitomycin C: mechanism of action, usefulness and limitations.. Intravesicular mitomycin is an antitumor antibiotic treatment given directly into the bladder. However, it can occur with any instillation.The purpose of this study is to compare the bladder cancer treatments, Mitomycin C (MMC) and Bacillus Calmette Guerin (BCG), to find out which is better.Mitomycin - Drug Info, Side Effects, Research, Clinical Trials. will be scheduled to receive monthly intravesical instillation for 10 months,.Mitomycin C is given as a chemotherapy,. mitomycin c intravesical Instillation. here in video we have instilled 40 mg of Mitomycin,.Mitomycin C is a mitomycin that is used as a chemotherapeutic agent by virtue of its antitumour. as well as by bladder instillation for superficial bladder tumours.. EAUN15 Guideline Intravesical ...
http://e-jual.tk/kogyp/mitomycin-instillation-medac-438.php
Mitomycin C - WikipediaMitomycin C - Wikipedia
Mitomycin C is a mitomycin that is used as a chemotherapeutic agent by virtue of its antitumour activity. It is given intravenously to treat upper gastro-intestinal cancers (e.g. esophageal carcinoma), anal cancers, and breast cancers, as well as by bladder instillation for superficial bladder tumours. It causes delayed bone marrow toxicity and therefore it is usually administered at 6-weekly intervals. Prolonged use may result in permanent bone-marrow damage. It may also cause lung fibrosis and renal damage. Mitomycin C has also been used topically rather than intravenously in several areas. The first is cancers, particularly bladder cancers and intraperitoneal tumours. It is now well known that a single instillation of this agent within 6 hours of bladder tumor resection can prevent recurrence. The second is in eye surgery where mitomycin C 0.02% is applied topically to prevent scarring during glaucoma filtering surgery and to prevent haze after PRK or LASIK; mitomycin C has also been shown to ...
https://en.wikipedia.org/wiki/Mitomycin_C
Differential effects of mitomycin C on constitutive and inducible gene expression in the chick embryo liver in vivo:...Differential effects of mitomycin C on constitutive and inducible gene expression in the chick embryo liver in vivo:...
Differential Effects of Mitomycin C on Constitutive and Inducible Gene Expression in the Chicken Embryo Liver In Vivo: Correlation with Developmental Age and Chromatin Structure A Thesis Submitted to the Faculty in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Pharmacology and Toxicology by Rosemary M. Caron DARTMOUTH COLLEGE Hanover, New Hampshire October 13, 1995 ...
http://libarchive.dartmouth.edu/cdm/compoundobject/collection/dcdis/id/209896/rec/40
Mitomycin Injection USP 2 & 10 mg - 3S CorporationMitomycin Injection USP 2 & 10 mg - 3S Corporation
Mitomycin was first investigated as an antibiotic in Japan. It was then found to be active as an antineoplastic agent. It selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The exact point of mitomycin attachment to DNA remains unknown. There is a correlation between the guanine and cytosine content of DNA and the degree of mitomycin-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed.Mitomycin Injection USP 2 & 10 mg is indicated as topical therapy for superficial (no invasion beyond the lamina propria) transitional cell carcinoma of the urinary bladder. Efficacy has been demonstrated both in patients who have had no prior intravesical chemotherapy and in those who have failed such therapy with thiotepa or other antineoplastic agents.. 3s corporation is Supplier,Exporter ,Wholesaler for Mitomycin Injection USP 2 & 10 mg in India.. India has many manufacturers who manufacture Mitomycin Injection USP 2 & 10 mg .To know ...
https://www.3scorporation.com/products/mitomycin-injection-usp-2-10-mg/
Kenneth B. Roberts, MD > Yale Cancer Center | Yale School of...Kenneth B. Roberts, MD > Yale Cancer Center | Yale School of...
During my first ten years on the Yale faculty, I participated in clinical trials evaluating the efficacy of bioreductive alkylating agents as an adjunct to radiotherapy in cervix cancer. A Phase III study comparing radiotherapy alone with radiotherapy plus Mitomycin C for cervix cancer has been completed in Venezuela with results showing a significant improvement in disease-free survival with the addition of Mitomycin C, which is a hypoxic cell cytotoxin. For several years, I had been collaborating with Interventional Cardiology and Medical Physics in a clinical program utilizing coronary brachytherapy to manage in-stent restenosis. Some current or upcoming clinical research projects include: 1) modifying radiation dose and volume in advanced stage Hodgkins disease based on response to initial chemotherapy (a cooperative group trial); 2) the effects of prostate edema during brachytherapy on modulating radiation dose delivery; 3) the changes in second malignancies seen after Hodgkins Lymphoma ...
http://yalecancercenter.org/research/people/kenneth_roberts-2.profile
Comparative analysis of individual chromosome involvement in micronuclei induced by mitomycin C and bleomycin in human...Comparative analysis of individual chromosome involvement in micronuclei induced by mitomycin C and bleomycin in human...
Micronucleus (MN) assay is a well standardized approach for evaluation of clastogenic/aneugenic effects of mutagens. Fluorescence in situ hybridization (FISH) is successfully used to characterize the chromosomal content of MN. However, the relationships between nuclear positioning, length, and gene density of individual chromosomes and their involvement in MN induced by different mutagens have not been clearly defined. Chromosomal content of MN was characterized in human leukocytes treated with mitomycin C (MMC) and bleomycin (BLM) by FISH using centromeric (cep) and whole-chromosome painting (wcp) probes. Involvement of chromosomes 8, 15 and 20 in MMC-induced and chromosomes 1, 9 and 16 in BLM-induced MN was studied, and correlated with chromosome size, gene density and interphase position. The results obtained were analyzed together with previous own data on the frequencies of inclusion of chromosomes 3, 4, 6, 7, 9, 16, 17, 18, and X in MMC-induced MN. It could be shown that MMC- and BLM-induced MN
https://molecularcytogenetics.biomedcentral.com/articles/10.1186/s13039-016-0258-4/tables/2
The effect of mitomycin C as fibrosis preventive agent during craniectomies | AVESİSThe effect of mitomycin C as fibrosis preventive agent during craniectomies | AVESİS
Object. The authors conducted a study to determine the effectiveness of mitomycin C (MMC) in preventing epidural fibrosis in rats which underwent craniectomy. Methods. Craniectomies were performed in the right frontoparietal region; after the procedure the animals had been divided in 2 groups of 10 each. Cotton pads soaked with 0.1mg/ml MMC or saline (control) were applied to the operative sites. Four weeks after craniectomy the rats were sacrificed, and epidural fibrosis was evaluated histologically. The dura mater thickness, the density of epidural fibrosis, arachnoidal involvement, and bone regeneration were determined. Results. No obvious adhesion formed in the rats in the MMC group, but severe epidural adhesions were found in control group. The duramater thickness, the density of epidural fibrosis, and arachnoidal involved rat number in the MMC group were significantly lower than in control groups. Conclusions. Epidural fibrosis can be a devastating condition that forms after craniectomy. ...
https://avesis.metu.edu.tr/yayin/dcf93443-7078-432b-99e2-af3ae0d2661e/the-effect-of-mitomycin-c-as-fibrosis-preventive-agent-during-craniectomies
Veliparib With or Without Mitomycin C in Treating Patients With Metastatic, Unresectable, or Recurrent Solid Tumors - Full Text...Veliparib With or Without Mitomycin C in Treating Patients With Metastatic, Unresectable, or Recurrent Solid Tumors - Full Text...
PRIMARY OBJECTIVES:. I. To screen cancer patients across different histological sites to identify those with functional defects in the Fanconi anemia (FA) pathway in their tumors.. II. To establish the safety and practicality of treating patients with FA deficient tumors with the poly (adenosine diphosphate [ADP]-ribose) polymerase (PARP) inhibitor ABT-888 (veliparib) as protracted monotherapy.. III. To establish the safety and practicality of treating patients with FA deficient tumors with the combination of mitomycin C (MMC) and ABT-888.. IV. To select a dose of ABT-888 protracted monotherapy and a dose-schedule of the combination of mitomycin C and ABT-888 in patients with FA deficient tumors for phase 2 trials.. SECONDARY OBJECTIVES:. I. To evaluate for germ-line FA repair deficiency and BRCA mutations in peripheral blood mononuclear (PBMC) in patients receiving ABT-888 treatment.. II. To evaluate in PBMC samples for foci produced by the histone variant gamma-H2A histone family, member X ...
https://clinicaltrials.gov/ct2/show/NCT01017640?term=Fanconi+anemia&recr=Open&fund=01&rank=4
Veliparib With or Without Mitomycin C in Treating Patients With Metastatic, Unresectable, or Recurrent Solid Tumors - Full Text...Veliparib With or Without Mitomycin C in Treating Patients With Metastatic, Unresectable, or Recurrent Solid Tumors - Full Text...
PRIMARY OBJECTIVES:. I. To screen cancer patients across different histological sites to identify those with functional defects in the Fanconi anemia (FA) pathway in their tumors.. II. To establish the safety and practicality of treating patients with FA deficient tumors with the poly (adenosine diphosphate [ADP]-ribose) polymerase (PARP) inhibitor ABT-888 (veliparib) as protracted monotherapy.. III. To establish the safety and practicality of treating patients with FA deficient tumors with the combination of mitomycin C (MMC) and ABT-888.. IV. To select a dose of ABT-888 protracted monotherapy and a dose-schedule of the combination of mitomycin C and ABT-888 in patients with FA deficient tumors for phase 2 trials.. SECONDARY OBJECTIVES:. I. To evaluate for germ-line FA repair deficiency and BRCA mutations in peripheral blood mononuclear (PBMC) in patients receiving ABT-888 treatment.. II. To evaluate in PBMC samples for foci produced by the histone variant gamma-H2A histone family, member X ...
https://clinicaltrials.gov/ct/show/NCT01017640
Mitomycin C is among the most reliable chemotherapeutic real estate agents - DNA Damage Signalling and Repair InhibitorsMitomycin C is among the most reliable chemotherapeutic real estate agents - DNA Damage Signalling and Repair Inhibitors
Mitomycin C is among the most reliable chemotherapeutic real estate agents for a broad spectrum of malignancies but its medical use continues to be hindered from the mitomycin C (MMC) delivery systems. higher anticancer impact set alongside the PLA NPs/MMC or free MMC injection and for several decades. SPC had always been regarded as a promising candidate for drug preparations due to the biocompatibility biodegradability metabolic activity and low toxicity and cytotoxicity compared to synthetic alternatives [31 33 34 Most significantly of all some advantages of the drug-phospholipid complex on the basis of the PLA NPs were as follows. Firstly the MMC-SPC complex was used as a structural element which could integrate the best of both polymer and lipid worlds and offer the integrity of the hybrid polymer-lipid nanoscaled drug delivery system. Secondly the MMC-SPC complex was served as a drug preparation to link the conventional and novel drug formulation which could increase the lipophilicity ...
http://ranscombehouseglynde.com/mitomycin-c-is-among-the-most-reliable-chemotherapeutic-real-estate-agents/
CRSToday | My Experience With a Gel StentCRSToday | My Experience With a Gel Stent
I have been working with the Xen45 gel stent (AqueSys; not FDA approved) for approximately 18 months and prior to that with its predecessor, the Xen 63. I have implanted more than 60 Xen45 devices. Unexpectedly, I have found it particularly beneficial in younger patients (25-60 years old) with marked IOP elevation who do not have significant optic nerve damage. From my perspective, the Xen comes closer to competing with trabeculectomy than other devices that I have used in the microinvasive glaucoma surgery category, though unlike the others, adjunctive mitomycin C is also required. I have seen IOPs of more than 50 mm Hg reduced to the low teens with this device. Trabeculectomy still remains a more effective option for low-failure-risk patients with advanced glaucoma requiring low target pressures. I also use the Xen in cataract patients who have advanced glaucoma controlled by multiple medications. With the Xen, postoperative IOP spikes and hypotony are avoided, and the procedure is ...
https://crstoday.com/articles/2015-oct/my-experience-with-a-gel-stent/
Mitomycin for injection by Hospira - Uses, Side Effects, Interactions - MedBroadcast.comMitomycin for injection by Hospira - Uses, Side Effects, Interactions - MedBroadcast.com
Mitomycin for injection by Hospira: Mitomycin belongs to the group of cancer-fighting medications known as antineoplastics, and specifically to the group of antineoplastics called actinomycins. Another actinomycin is dactinomycin.
http://www.medbroadcast.com/drug/getdrug/mitomycin-for-injection-by-hospira
Mitomycin (Mutamycin) | Daviss Drug GuideMitomycin (Mutamycin) | Daviss Drug Guide
Find information on Mitomycin (Mutamycin) in Daviss Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Davis Drug Guide PDF.
https://anesth.unboundmedicine.com/anesthesia/view/Davis-Drug-Guide/51510/all/mitoMYcin?q=zidovudine
Primary Dermal Fibroblast; Normal, Human, Neonatal, Mitomycin C TreatePrimary Dermal Fibroblast; Normal, Human, Neonatal, Mitomycin C Treate
ATCC ® Mitomycin C Treated Normal Human Neonatal Dermal Fibroblasts, when recovered in complete fibroblast growth media, provide an ideal cell system to establish serum-free (or low serum) human feeder layers for the culture of embryonic stem cells or other cell types requiring a feeder layer for optimal proliferation. The cells are cryopreserved in the second passage to ensure the highest viability and plating efficiency. ATCC ® Primary Cell Solutions cells, media, supplements and reagents are quality tested together to guarantee optimum performance and reliability.
https://www.atcc.org/Products/Cells_and_Microorganisms/Human_Primary_Cells/Alphanumeric/PCS-201-011.aspx
Mitomycin C Supplier | CAS 50-07-7 | Ametycine | Tocris BioscienceMitomycin C Supplier | CAS 50-07-7 | Ametycine | Tocris Bioscience
View and buy high purity Mitomycin C from Tocris Bioscience, the leading worldwide supplier of high performance life science reagents.
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Mitomycin C | CAS 50-07-7 | SCBT - Santa Cruz BiotechnologyMitomycin C | CAS 50-07-7 | SCBT - Santa Cruz Biotechnology
Buy this product (CAS 50-07-7), a DNA crosslinking agent that inhibits DNA synthesis, induces apoptosis in a variety of cells, and activates caspase, from Santa Cruz. Purity: ≥99%
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Mitomycin Intravenous Advanced Patient Information - Drugs.comMitomycin Intravenous Advanced Patient Information - Drugs.com
Detailed drug Information for mitomycin Intravenous. Includes common brand names, drug descriptions, warnings, side effects and dosing information.
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Mitomycin tx | allnursesMitomycin tx | allnurses
When adminstering mitomycin intravesically to patients; I draw it up in a 60-cc syringe and then I have someone else assist to pour the solution into a catheter syringe after I catheterize the
http://allnurses.com/dialysis-renal-urology/mitomycin-tx-60633.html
Download Ivor Hortons Beginning Visual C Plus PlusDownload Ivor Hortons Beginning Visual C Plus Plus
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Inaccessibility of medications to poorly vascularized strata of tumor is among the limiting elements in tumor therapy. RT-PCR for FasL mRNA. THP-1 M had been treated with indicated concentrations of MMC, and prepared for RT-PCR. in the rules of FasL manifestation. (i) Traditional western blot evaluation of PPARin MMC-treated cells. HeLa, SiHa and THP-1 M […]. ...
http://labsmart.net/tag/176708-42-2-manufacture/
SpringerExemplar - mitomycin - Scientific Language Search
Evaluation of selected antitumor agents as subversive substrate and potential inhibitor of trypanothione reductase: an alternative approach for chemotherapy of ...
http://springerexemplar.com/search.aspx?q=mitomycin&val=subject%3ALife+Sciences
Search Results - mitomycinSearch Results - mitomycin
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SpringerExemplar - mitomycin - Scientific Language Search
Dorp, F.; Eisenhardt, A.; Goebell, P.-J.; Gschwend, J.; Jakse, G.; Jäger, T.; Jocham, D.; Karl, A.; Knüchel Clarke, R.; Krege, S.; Lümmen, G.; Ohlmann, C.; Olbricht, T.; Otto, T.; Rettenmeier, A.; Rübben, H.; Schenck, M.; Schmid, K.W.; Stief, C.; Stöckle, M.; Tritschler, S ...
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Whats all the C Plus Fuss? Bjarne Stroustrup warns of dangerous future plans for his C++ • The Register ForumsWhats all the C Plus Fuss? Bjarne Stroustrup warns of dangerous future plans for his C++ • The Register Forums
I have to say, just that simple for-loop is a prime example of why I dont like C++.. I can memorise the entire standard library of C, and every command in it, and every operator, and every syntax. Nobody can then run up a piece of code which cant be deciphered (sure, I may have to play pre-processor games, but everything will come down to obvious code).. When there are a dozen ways to iterate over a simple group of objects, and half-a-dozen different groups of objects, and obscure syntactic sugar the people use because it saves them a fraction of a second, it quickly becomes a pain to understand. Which means its a pain to verify. Which means its a pain to secure. Which is not what you want in something like C/C++.. The hidden effects of such code, where things are iterated upon, objects are instantiated, etc. behind your back is a real pain to me. Its like every simple line becoming a dozen subroutines, overrode and silently inserted, and no obvious way to tell thats whats happening ...
https://forums.theregister.com/forum/all/2018/06/18/bjarne_stroustrup_c_plus_plus/
Ester C Plus 1000mgEster C Plus 1000mg
Ester C is a form of vitamin C which gets into the bloodstream faster and in larger amounts with less waste. It also allows the vitamin C to penetrate the white blood cells more efficiently.Vitamin C acts as an antioxidant, it is also important for the ma
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MITC-STO (ATCC 56-X) ATCC® 56-X.2™MITC-STO (ATCC 56-X) ATCC® 56-X.2™
These cells are to be used as feeder cells to support the growth of other cells. They have been treated with Mitomycin C and will not replicate.
https://www.atcc.org/en/Products/Cells_and_Microorganisms/Stem_Cells/Feeder_Cells/56-X.2.aspx?slp=1
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MMC TV LAŠKO - ŠMOCLMMC TV LAŠKO - ŠMOCL
MMC TV LAŠKO. MMC TV Laško je spletna televizija, ki v lokalnem okolju deluje od leta 2011. V letu 2015 smo posodobili našo spletno stran, ki ponuja večjo preglednost in dostopnost medijskih vsebin. Priprava prispevkov in oddaj na lokalni ravni oziroma o lokalnem dogajanju je pomembna za raznolikost medijskih vsebin v Sloveniji in predvsem za enakopravno uresničevanje pravice tudi lokalnega in regionalnega prebivalstva do javnega obveščanja ter objektivne obveščenosti.. Občina Laško je ena največjih občin v Sloveniji, kar pomeni veliko število dogodkov, dejavnosti in tudi problematike v mestu in okoliških krajih. Dogajanje v občini je večkrat povezano tudi z ohranjanjem tradicij in slovenske kulture, pri čemer ste najbolj dejavni predvsem lokalna društva in organizacije, v občini se večkrat pojavlja problematika varstva pred naravnimi nesrečami, mnogo je gospodarskih subjektov, navsezadnje pa se v naši občini skriva veliko posameznikov z zgodbami, izkušnjami in predlogi, ...
http://smocl.com/tv-lasko-in-studio/
Pre- and intraoperative mitomycin C for recurrent pterygium associated | OPTHPre- and intraoperative mitomycin C for recurrent pterygium associated | OPTH
Pre- and intraoperative mitomycin C for recurrent pterygium associated with symblepharon Isyaku MohammedDepartment of Ophthalmology, Aminu Kano Teaching Hospital, Kano, NigeriaBackground: Treatment of recurrent pterygium associated with symblepharon usually involves the use of tissue grafting and/or the intraoperative application of mitomycin C (MMC). For the graft, a conjunctival/limbal autograft and/or amniotic membrane may be used. This generally requires extra technical skills and assistance, an increase in the cost and duration of surgery, and a more extensive anesthesia (a complete eye block or general anesthesia). Although widely used, safety concerns have been raised over MMC in the treatment of pterygia.Objective: The objective of this case report is to report the successful use of preoperative subconjunctival injection of low-dose (0.02%) MMC one month before bare sclera excision of a multirecurrent pterygium, as well as the concomitant intraoperative application of MMC to the conjunctival
https://www.dovepress.com/pre--and-intraoperative-mitomycin-c-for-recurrent-pterygium-associated-peer-reviewed-article-OPTH
Injected Versus Sponge-Applied Mitomycin C (MMC) During Modified Trabeculectomy in New Zealand White Rabbit Model | TVST | ARVO...Injected Versus Sponge-Applied Mitomycin C (MMC) During Modified Trabeculectomy in New Zealand White Rabbit Model | TVST | ARVO...
Goblet cell counts were greater in the injected MMC group compared the sponge-applied MMC group. Both MMC groups demonstrated lower goblet cell counts compared to the non-injured control group. The underlying cause for the difference in the MMC groups could be due to the concentrated, focal application in the sponge-applied MMC group versus the broader and less concentrated application of MMC in the injected group. This is important, as ocular surface disease (OSD) is a significant source of the morbidity in patients following glaucoma filtration surgery. Goblet cells play a crucial role in tear film stability and in the maintenance of a healthy ocular surface. Patients with low goblet cell counts have been reported to have reduced tear breakup times.11 Interestingly, the BSS control eyes demonstrated a lower number of goblet cells compared to the injected MMC group. Although this result was not statistically significant, it highlights the interplay of goblet cells and medication-induced ...
https://tvst.arvojournals.org/article.aspx?articleid=2770936
Abnormal sequence distribution in DNA synthesized by isolated nuclei from normal or mitomycin C-treated HeLa cells. - Semantic...Abnormal sequence distribution in DNA synthesized by isolated nuclei from normal or mitomycin C-treated HeLa cells. - Semantic...
Semantic Scholar extracted view of Abnormal sequence distribution in DNA synthesized by isolated nuclei from normal or mitomycin C-treated HeLa cells. by Masamichi Yamada et al.
https://www.semanticscholar.org/paper/Abnormal-sequence-distribution-in-DNA-synthesized-Yamada-Weissbach/a57f0dc07b8d4b0ecd4fed7575318a02d6f485d7
Plus itPlus it
Solid neoplasms may contain deficient or poorly functional vascular beds, a property that leads to the formation of hypoxic tumor cells, which form a therapeutically resistant cell population within the tumor that is difficult to eradicate by ionizing irradiation and most existing chemotherapeutic agents. As an approach to the therapeutic attack of hypoxic cells, we have measured the cytotoxicity and DNA lesions produced by the bioreductive alkylating agents mitomycin C and porfiromycin, two structurally similar antibiotics, in oxygen-deficient and aerobic cells. Mitomycin C and porfiromycin were preferentially cytotoxic to hypoxic EMT6 cells in culture, with porfiromycin producing a greater differential kill of hypoxic EMT6 cells relative to their oxygenated counterparts than did mitomycin C. Chinese hamster ovary cells were more resistant to these quinone antibiotics; although in this cell line, porfiromycin was significantly more cytotoxic to hypoxic cells than to aerobic cells, and the ...
http://cancerres.aacrjournals.org/content/46/8/3939
Successful treatment of tracheal stenosis by rigid bronchoscopy and topical mitomycin C: a case report | Cases Journal | Full...Successful treatment of tracheal stenosis by rigid bronchoscopy and topical mitomycin C: a case report | Cases Journal | Full...
The optimal treatment of tracheal stenosis remains undefined. Traditionally, tracheal stenosis has been managed by thoracic and othorhinolaryngology surgeons. Endoscopic procedures are usually performed as a bridge to definitive surgical intervention. With the development of interventional pulmonology field in the last 20 years, definitive management of tracheal stenosis using minimally invasive endoscopic methods became a possibility. Collaboration between pulmonologists and surgeons has become increasingly important to help define the best method of management for these patients.. Endoscopic treatment had been shown to be useful, especially in patients who are deemed high risk and too unwell for reconstructive surgery. One of the main drawbacks of endoscopic treatment and surgery is the risk of recurrence of trachea stenosis due to granulation and fibrotic tissue. Studies have shown that most of the recurrence of tracheal stenosis occurs within one to three months after the procedure [12, 14], ...
https://casesjournal.biomedcentral.com/articles/10.1186/1757-1626-3-2
Conjunctival Short-term Evolution after Pterygium ExcisionConjunctival Short-term Evolution after Pterygium Excision
Purpose To analyze conjunctival cytological features 1 month after pterygium excision using limbo-conjunctival autograft (LCA) with and without intraoperative mitomycin C and to assess tissue short-term evolution in both situations.; Methods Fifty-nine primary nasal pterygia from 59 patients were excised with LCA. Twenty-nine were treated with intraoperative mitomycin C 0.02% (MMC+) and 30 were treated without it (MMC-). Impression cytology was performed in nasal and temporal conjunctiva before and 1 month after the excision. Goblet cell density (GCD) and nucleus-to-cytoplasm nongoblet epithelial cell ratio were quantified.; Results Surgical strategy comparisons (intergroup comparisons): All the preoperative data were, in mean, within the reference range, except for a slight goblet cell hyperplasia in the area of the lesion in MMC+ but no significant differences were found between the groups (p = 0.079 for GCD and p = 0.245 for nucleus-to-cytoplasm ratio; analysis of variance). Clinically ...
http://upcommons.upc.edu/handle/2117/79559
Mitomycin and Interstitial Pneumonitis | Annals of Internal Medicine | American College of PhysiciansMitomycin and Interstitial Pneumonitis | Annals of Internal Medicine | American College of Physicians
To the editor: Orwoll and others (1) have reported in the September issue on the association of mitomycin with interstitial pneumonia. In the past 2 years we have seen two patients who died with unexplained severe interstitial pneumonitis after receiving mitomycin chemotherapy.. The first case was that of a 53-year-old man with adenocarcinoma of the pancreas who received weekly mitomycin, 5-fluorouracil, and cytosine arabinoside during an 18-week period for a total mitomycin dose of 50 mg. He developed progressive dyspnea leading to death within 3 weeks after a short preterminal period of progressive dyspnea. At autopsy, alveolar septal thickening and ...
http://annals.org/aim/article-abstract/692691/mitomycin-interstitial-pneumonitis
Bleb needling with mitomycin C as adjunctive therapy in failing blebs: A retrospective study<...
TY - JOUR. T1 - Bleb needling with mitomycin C as adjunctive therapy in failing blebs. T2 - A retrospective study. AU - Del Noce, Chiara. AU - Vagge, Aldo. AU - Traverso, Carlo Enrico. PY - 2019/6/1. Y1 - 2019/6/1. N2 - Purpose: To evaluate the effects and complications related to use of mitomycin C (MMC) as an adjunctive therapy in bleb needling. Methods: Retrospective review of the records of patients affected by open-angle glaucoma who underwent a bleb revision as a treatment for failed trabeculectomy. All subjects underwent surgery with a fornix-based approach to incision. Full baseline data for each patient included a comprehensive ocular and medical history, the patients Snellen visual acuity test results, and Goldmann applanation tonometry test results. Data were reported following observations occurring at 6, 12, 18, 24, and 30 months. In addition, the number and timing of needling with or without MMC subconjunctival injections and any short- and long-term complications were observed. ...
https://moh-it.pure.elsevier.com/en/publications/bleb-needling-with-mitomycin-c-as-adjunctive-therapy-in-failing-b-2
Prophage Induction and Differential RecA and UmuDAb Transcriptome Regu by Janelle M. Hare, Joshua C. Ferrell et al.Prophage Induction and Differential RecA and UmuDAb Transcriptome Regu by Janelle M. Hare, Joshua C. Ferrell et al.
The SOS response to DNA damage that induces up to 10% of the prokaryotic genome requires RecA action to relieve LexA transcriptional repression. In Acinetobacter species, which lack LexA, the error-prone polymerase accessory UmuDAb is instead required for ddrR induction after DNA damage, suggesting it might be a LexA analog. RNA-Seq experiments defined the DNA damage transcriptome (mitomycin C-induced) of wild type, recA and umuDAb mutant strains of both A. baylyi ADP1 and A. baumannii ATCC 17978. Of the typical SOS response genes, few were differentially regulated in these species; many were repressed or absent. A striking 38.4% of all ADP1 genes, and 11.4% of all 17978 genes, were repressed under these conditions. In A. baylyi ADP1, 66 genes (2.0% of the genome), including a CRISPR/Cas system, were DNA damageinduced, and belonged to four regulons defined by differential use of recA and umuDAb. In A. baumannii ATCC 17978, however, induction of 99% of the 152 mitomycin C-induced genes depended on recA,
https://scholarworks.moreheadstate.edu/msu_faculty_research/272/
Mitomycin C 10Mg Injection - Uses, Side Effects, Substitutes, Composition And More | LybrateMitomycin C 10Mg Injection - Uses, Side Effects, Substitutes, Composition And More | Lybrate
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Mitomycin C (MMC), a known cytotoxic agent, requires cellular enzyme-mediated activation for effective antitumor activity. To study the bioreductive enzymes responsible for MMC activation in tumor cells, we examined the enzyme activities of DT-diaphorase (DTD) and NADPH: cytochrome P-450 reductase in 13 colon and gastric carcinoma cell lines and then compared these activities to the respective cellular MMC sensitivity. We found that cell lines with nonexistent or marginal DTD activity, such as St-4 and MKN7, showed resistance to MMC, in comparison to cell lines with DTD activity ranging from 210 to 1420 nmol/min/mg protein. No correlation was found between NADPH:cytochrome P-450 reductase activity and MMC sensitivity in these cell lines. To confirm the role of DTD in cellular MMC sensitivity, we constructed an expression vector containing NQO1, a gene that codes for DTD, and transfected the vector into St-4 cells expressing no DTD activity. Several transfectant clones with DTD activity from 144 ...
http://cancerres.aacrjournals.org/content/56/12/2823
Identification and Characterization of Novel Genotoxic Stress-Inducible Nuclear Long Noncoding RNAs in Mammalian CellsIdentification and Characterization of Novel Genotoxic Stress-Inducible Nuclear Long Noncoding RNAs in Mammalian Cells
Whole transcriptome analyses have revealed a large number of novel transcripts including long and short noncoding RNAs (ncRNAs). Currently, there is great interest in characterizing the functions of the different classes of ncRNAs and their relevance to cellular processes. In particular, nuclear long ncRNAs may be involved in controlling various aspects of biological regulation, such as stress responses. By a combination of bioinformatic and experimental approaches, we identified 25 novel nuclear long ncRNAs from 6,088,565 full-length human cDNA sequences. Some nuclear long ncRNAs were conserved among vertebrates, whereas others were found only among primates. Expression profiling of the nuclear long ncRNAs in human tissues revealed that most were expressed ubiquitously. A subset of the identified nuclear long ncRNAs was induced by the genotoxic agents mitomycin C or doxorubicin, in HeLa Tet-off cells. There were no commonly altered nuclear long ncRNAs between mitomycin C- and doxorubicin-treated cells.
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0034949
Regulation of Responsiveness of Cultured Adrenal Cells to Adrenocorticotropin and Prostaglandin E<sub>1</sub>: Cell Density,...Regulation of Responsiveness of Cultured Adrenal Cells to Adrenocorticotropin and Prostaglandin E<sub>1</sub>: Cell Density,...
TY - JOUR. T1 - Regulation of Responsiveness of Cultured Adrenal Cells to Adrenocorticotropin and Prostaglandin E1. T2 - Cell Density, Cell Division, and Inhibitors of Protein Synthesis. AU - Hornsby, Peter J.. AU - Gill, Gordon N.. PY - 1981/1. Y1 - 1981/1. N2 - In cultured bovine adrenocortical cells, responsiveness to ACTH, as assessed by the maximal rate of ACTHstimulated cAMP production, has been found to depend on cell density and cell proliferation, while the maximal rate of prostaglandin E1, (PGE1)-stimulated cAMP production was constant.The combination of low cell density and normal cell proliferation caused a specific decline in responsiveness to ACTH. Responsiveness did not decline at any density when proliferation was inhibited by mitomycin C treatment. Specific declines in responsiveness to ACTH were also seen when cultures were treated with cycloheximide or sodium butyrate. When protein synthesis was completely inhibited by cycloheximide treatment, responsiveness to ACTH declined ...
https://scholars.uthscsa.edu/en/publications/regulation-of-responsiveness-of-cultured-adrenal-cells-to-adrenoc
Mitomycin-C - UNM Comprehensive Cancer CenterMitomycin-C - UNM Comprehensive Cancer Center
Trade Name: Mutamycin®. How is this drug used? Mitomycin is FDA approved for the treatment of advanced stomach and pancreatic cancer in combination with other agents. It is important for patients to remember that physicians have the ability to prescribe medication for conditions other than those for which the drug has been approved by the FDA. Patients who have received a prescription of this drug for a condition other than which it is approved may wish to discuss this issue with their physician.. What is the mechanism of action? Mitomycin belongs to a class of agents called antitumor antibiotics. An antitumor antibiotic produces its anti-cancer effects by binding to DNA and inhibiting the production of proteins necessary for sustaining the life of a cell.. How is mitomycin given (administered)? Mitomycin may be administered into a vein (intravenous) and the dose depends on several factors, including the condition being treated, the size of the patient, the particular treatment regimen being ...
http://cancer.unm.edu/2009/04/28/mitomycin-c-2/
Wu HI~Brown JM, 2004 / Papers / YeastPhenome.org
Cisplatin is a crucial agent in the treatment of many solid tumors, yet many tumors have either acquired or intrinsic resistance to the drug. We have used the homozygous diploid deletion pool of Saccharomyces cerevisiae, containing 4728 strains with individual deletion of all nonessential genes, to systematically identify genes that when deleted confer sensitivity to the anticancer agents cisplatin, oxaliplatin, and mitomycin C. We found that deletions of genes involved in nucleotide excision repair, recombinational repair, postreplication repair including translesional synthesis, and DNA interstrand cross-link repair resulted in sensitivity to all three of the agents, although with some differences between the platinum drugs and mitomycin C in the spectrum of required translesional polymerases. Putative defective repair of oxidative damage (imp2Delta strain) also resulted in sensitivity to platinum and oxaliplatin, but not to mitomycin C. Surprisingly in light of their different profiles of ...
http://yeastphenome.org/papers/186/
北京大学医学部机构知识库([email protected]): Non-caspase-mediated apoptosis contributes to the potent cytotoxicity of the enediyne antibiotic...
Enediyne antibiotics have been reported to be the most potent cytotoxic antitumor agents. The pathway by which these compounds cleave DNA and induce apoptosis of tumor cells may be different from the caspase-mediated pathways that initiate typical apoptosis. In this report, we studied the apoptosis induced by lidamycin (LDM), a member of the enediyne antibiotic family, and compared the characteristics of LDM-induced apoptosis with those of typical apoptosis induced by mitomycin C or etoposide. Chromatin condensation occurred very rapidly and appeared as speckles in human hepatoma BEL-7402 and breast carcinoma MCF-7 cells after treatment with I muM LDM. In addition, co-staining the cells with the mitochondria-specific dye Mitosensor(TM) and the DNA-specific dye Hoechst 33342 enabled the visualization of mitochondria in normal control and LDM-treated cells but not in mitomycin C-treated cells. Neither the caspase inhibitor VAD-fmk nor the caspase-3 inhibitor DEVD-fmk was able to inhibit the DNA ...
http://ir.bjmu.edu.cn/handle/400002259/50543
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Randomized trial of 5-fluorouracil and mitomycin-C with or without streptozotocin for advanced pancreatic cancer
A prospective randomized trial comparing streptozotocin, mitomycin C, and 5-FU (SMF) with mitomycin C and 5-FU (MF) in patients with advanced pancreatic cancer was performed. In patients with measurable disease the response rates were 34% (19/56) to SMF, and 8% (5/60) to MF (P = 0.009). Median survivals were similar, however, 18 versus 17 weeks (P = 0.356). Median survival of patients responding to chemotherapy was 33 weeks, and for nonresponders it was 17 weeks (P = 0.002). In patients with nonmeasurable disease, median survivals were 21 weeks (SMF) and 18 weeks (MF) (P = 0.797). Patients surviving greater than or equal to 48 weeks, however, appeared to be increased in the SMF arm (14 patients) compared to the MF (7 patients). Toxicity was moderate for both regimens, with SMF having greater gastrointestinal and renal toxicity. Chemotherapy with SMF appears to produce objective responses in patients with pancreatic cancer, but does not improve survival compared to MF ...
http://www.meb.uni-bonn.de/cgi-bin/mycite?ExtRef=MEDL/84001831/PMID/6225508
Randomized trial of 5-fluorouracil and mitomycin-C with or without streptozotocin for advanced pancreatic cancer
A prospective randomized trial comparing streptozotocin, mitomycin C, and 5-FU (SMF) with mitomycin C and 5-FU (MF) in patients with advanced pancreatic cancer was performed. In patients with measurable disease the response rates were 34% (19/56) to SMF, and 8% (5/60) to MF (P = 0.009). Median survivals were similar, however, 18 versus 17 weeks (P = 0.356). Median survival of patients responding to chemotherapy was 33 weeks, and for nonresponders it was 17 weeks (P = 0.002). In patients with nonmeasurable disease, median survivals were 21 weeks (SMF) and 18 weeks (MF) (P = 0.797). Patients surviving greater than or equal to 48 weeks, however, appeared to be increased in the SMF arm (14 patients) compared to the MF (7 patients). Toxicity was moderate for both regimens, with SMF having greater gastrointestinal and renal toxicity. Chemotherapy with SMF appears to produce objective responses in patients with pancreatic cancer, but does not improve survival compared to MF ...
https://imsdd.meb.uni-bonn.de/cgi-bin/mycite?ExtRef=MEDL/84001831/PMID/6225508
Coregulation of FANCA and BRCA1 in human cells | SpringerPlus | Full TextCoregulation of FANCA and BRCA1 in human cells | SpringerPlus | Full Text
Fanconi anemia (FA) is a rare, recessive, genetically heterogeneous, chromosomal instability disorder, characterized by developmental abnormalities, retarded growth, bone marrow failure, and a high risk for the development of cancer (Auerbach et al. 2001; Alter 2003; Rosenberg et al. 2003; Kutler et al. 2003). Fanconi anemia patient-derived cells are extremely sensitive to bifunctional alkylating or DNA interstrand cross-linking agents, such as mitomycin C and cisplatin (Ishida and Buchwald 1982; Wang 2007).. Currently, sixteen FA genes have been identified, each corresponding to a distinct complementation group: FA-A, -B, -C, -D1, -D2, -E, -F, -G, -I, -J, -L, -M, -N, -O, -P, and -Q (Strathdee et al. 1992; Pronk et al. 1995; Apostolou et al. 1996; Lo Ten Foe et al. 1996; de Winter et al. 1998, 2000a, b; Waisfisz et al. 1999; Timmers et al. 2001; Howlett et al. 2002; Meetei et al. 2003, 2004, 2005; Levitus et al. 2005; Levran et al. 2005a; Dorsman et al. 2007; Xia et al. 2007; Smogorzewska et ...
https://springerplus.springeropen.com/articles/10.1186/2193-1801-3-381
Presenting symptoms predict local staging of anal cancer: a retrospective analysis of 86 patients | BMC Gastroenterology | Full...Presenting symptoms predict local staging of anal cancer: a retrospective analysis of 86 patients | BMC Gastroenterology | Full...
In this study we provide a comprehensive clinical characterization of a cohort of patients with newly diagnosed anal carcinoma. According to our analyses, clinical symptoms have predictive value for local staging of anal carcinoma.. Our study fills a gap in our knowledge since no systematic study regarding physical findings in anal carcinoma has been performed. Furthermore, no contemporary study describing the clinical presentation of anal carcinoma is available and the incidence of anal carcinoma, the prevalence of risk factors and medical practice has tremendously changed since the publication of the last paper characterizing anal carcinoma almost 30 years ago [10-14]. In agreement with previous studies, bleeding, anal pain and sensation of an anal mass remain the most frequent symptoms of anal carcinoma. However, the presence of anal pain including painful defecation and perianal pain (63 vs. 20-35 %) as well as anal bleeding (77 vs. 45 %) were more frequent than in historical studies ...
https://bmcgastroenterol.biomedcentral.com/articles/10.1186/s12876-016-0461-0
A phase III comparison trial of streptozotocin, mitomycin, and 5-fluorouracil with cisplatin, cytosine arabinoside, and...
Conventional chemotherapy for unresectable or metastatic adenocarcinoma of the pancreas has had little effect on palliation or survival. Almost all studies of systemic therapy have involved empiric use of a variety of Phase II or conventional agents alone or in combination. On the basis of recent studies using a human tumor pancreatic cancer (PC) xenograft in nude mice, a Phase I clinical trial of cisplatin, high-dose cytosine arabinoside (Ara-C), and caffeine (CAC) was performed in patients with advanced incurable PC. A tolerable dose and schedule of the three agents were developed. Seven of 18 patients with measurable disease in this Phase I trial had partial responses to CAC. A Phase III comparison of CAC versus standard treatment using streptozotocin, mitomycin, and 5-fluorouracil (SMF) was performed. Eighty-two patients with advanced PC were entered into this random assignment trial. The two treatment arms were well balanced for the usual prognostic factors. Although the acute (e.g., nausea ...
https://imsdd.meb.uni-bonn.de/cgi-bin/mycite?ExtRef=MEDL/92005226/PMID/1833042
p53-dependent and p53-independent activation of apoptosis in mammary epithelial cells reveals a survival function of EGF and...p53-dependent and p53-independent activation of apoptosis in mammary epithelial cells reveals a survival function of EGF and...
The p53 tumor suppressor protein has been implicated as a mediator of programmed cell death (PCD). A series of nontransformed mammary epithelial cell (MEC) lines were used to correlate p53 function with activation of PCD. Treatment of MECs expressing mutant, inactive, or no p53 with DNA-damaging agents did not induce apoptosis. Upon introduction of temperature-sensitive p53 into HC11 cells, which lack wild-type (wt) p53, PCD was observed after mitomycin treatment at 32 degrees, when the ts p53 protein is in wt conformation. Thus, wt p53 mediates activation of PCD in response to mitomycin in HC11 cells. Treatment of the MCF10-A cells, which express wt p53, with various DNA-damaging agents led to nuclear accumulation of p53. Only mitomycin treatment led to an increase in the number of apoptotic nuclei. ErbB-2-transformed MCF10-A cells responded to mitomycin, cisplatin, and 5-Fl-uracil, suggesting that signaling from activated ErbB-2 enhances the cells ability to respond to DNA damage. A ...
http://jcb.rupress.org/content/128/6/1185
Efficacy and Safety of Mitomycin C as an Agent to Treat Corneal Scarri by Dylan G. Buss, Ajay Sharma et al.Efficacy and Safety of Mitomycin C as an Agent to Treat Corneal Scarri by Dylan G. Buss, Ajay Sharma et al.
Objective-Mitomycin C (MMC) is used clinically to treat corneal scarring in human patients. We investigated the safety and efficacy of MMC to treat corneal scarring in horses by examining its effects at the early and late stages of disease using an in-vitro model. Procedure-An in-vitro model of equine corneal fibroblast (ECF) developed was used. The equine corneal fibroblast or myofibroblast cultures were produced by growing primary ECF in the presence or absence of transforming growth factor beta-1 (TGFβ1) under serum-free conditions. The MMC dose for the equine cornea was defined with dose-dependent trypan blue exclusion and MTT [(3-4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assays after applying MMC to the cultures once for 2 minutes. The efficacy of MMC to control corneal scarring in horses was determined by measuring mRNA and protein expression of corneal scarring markers (α-smooth muscle actin and F-actin) with western blotting, immunocytochemistry and/or quantitative realtime
https://digitalcommons.chapman.edu/pharmacy_articles/546/
Porfiromycin | CTDPorfiromycin | CTD
Toxic antibiotic of the mitomycin group, obtained from MITOMYCIN and also from Streptomyces ardus and other species. It is proposed as an antineoplastic agent, with some antibiotic properties ...
http://ctdbase.org/detail.go?type=chem&acc=D011160
Mitomycin C induces bystander killing in homogeneous and heterogeneous hepatoma cellular models | Springer for Research &...Mitomycin C induces bystander killing in homogeneous and heterogeneous hepatoma cellular models | Springer for Research &...
Background Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide that is particularly refractory to chemotherapy. Several studies have proposed combination chemotherapy regimen...
https://rd.springer.com/article/10.1186/1476-4598-8-87
Mitomycin C | Valiant | BiozMitomycin C | Valiant | Bioz
Mmc, supplied by Valiant, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/mitomycin%20c/product/Valiant
Enhancement of antitumor activity of mitomycin C in vitro and in vivo by UCN-01, a selective inhibitor of protein kinase CEnhancement of antitumor activity of mitomycin C in vitro and in vivo by UCN-01, a selective inhibitor of protein kinase C
UCN-01 (7-hydroxy-staurosporine) is a potent and selective inhibitor of protein kinase C (PKC), one of several protein kinases examined. UCN-01 itself was shown to exhibit antitumor activity in vitro and in vivo in oncogene-activated human and murine tumor cell lines. Since the mechanism(s) of actio …
https://pubmed.ncbi.nlm.nih.gov/8500222/?dopt=Abstract
adverse reactions to one time mitomycin c - Bladder Cancer Support Forumadverse reactions to one time mitomycin c - Bladder Cancer Support Forum
I have recently been diagnosed with hemoraghic interstitial cystitis, and I only had one treatment right after TURBT in 9/2012. This was done to me without my...
https://www.bladdercancersupport.org/bladder-cancer-forum/3-newly-diagnosed/44830-adverse-reactions-to-one-time-mitomycin-c.html
Mitomycin C in patients with gynecological malignancies. | Sigma-AldrichMitomycin C in patients with gynecological malignancies. | Sigma-Aldrich
Sigma-Aldrich offers abstracts and full-text articles by [Laura Kahmann, Ulrich Beyer, Grit Mehlhorn, Falk C Thiel, Vratislav Strnad, Peter A Fasching, Michael P Lux].
https://www.sigmaaldrich.com/catalog/papers/20926904
mitomycin C (CHEBI:27504)mitomycin C (CHEBI:27504)
Chemical Entities of Biological Interest (ChEBI) is a freely available dictionary of molecular entities focused on small chemical compounds.
http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:27504
Anal Carcinoma: Anatomy
Another name for Anal Carcinoma is Anal Cancer. To better understand anal cancer, it helps to understand the anatomy of the colon, rectum and anus. The ...
http://www.freemd.com/anal-carcinoma/anatomy.htm
Optimum time to assess complete clinical response (CR) following chemoradiation (CRT) using mitomycin (MMC) or cisplatin (CisP)...Optimum time to assess complete clinical response (CR) following chemoradiation (CRT) using mitomycin (MMC) or cisplatin (CisP)...
OncoLink, the Webs first cancer resource,provides comprehensive information on coping with cancer, cancer treatments, cancer research advances, continuing medical education, cancer prevention, and clinical trials
https://www.oncolink.org/conferences/coverage/asco/oncolink-at-asco-2012/oncolink-reports-from-asco-2012/optimum-time-to-assess-complete-clinical-response-cr-following-chemoradiation-crt-using-mitomycin-mmc-or-cisplatin-cisp-with-or-without-maintenance-cisp-5fu-in-squamous-cell-carcinoma-of-the-anus-results-of-act-ii
Differential Diagnosis: mitomycin, Multiple skin lesions
Logical Images, Inc. d/b/a VisualDx (hereinafter VisualDx, we, us, or our) has created this Acceptable Use Policy, Medical Disclaimer, & Copyright Notice (this Notice) to inform you (hereinafter you, your, or yourself) as a purchaser of a license for and/or user of the software hosted by VisualDx known as VisualDx (the Software) of certain important terms and conditions set forth in the VisualDx End User License Agreement that governs your license for and/or use of the Software (the EULA). This Notice is subject to all of the terms and conditions set forth in the EULA and does not replace or limit it in anyway. You should read the EULA in detail prior to purchasing a license for or using the Software to make sure you understand and agree to its terms and conditions. Nothing in this Notice will (a) expand your rights or VisualDx′s obligations under the EULA or (b) modify or otherwise affect any terms and conditions of the EULA or the rights of the parties under the EULA. In ...
https://www.visualdx.com/visualdx/differential/mitomycin/multiple%20skin%20lesions?moduleId=100&findingId=22436,25221&reqFId=22436
K & C plus FOUR!: Team Babies - Happy Birthday - April 9th, 2013
I was hanging out at Jamies house on April 8th - watching the Voice, playing Battleship with the kids like any other night. I left her house late that night knowing I would see her in the morning at our 32 week, 5 day appointment/ultrasound. We were both so excited to see how much these babies weighed and make sure everything was still going great. The next morning I woke up at 4:48am to my phone vibrating. I see a call from Jamie Dabo and my heart started racing. I think I was still somewhere between a dream and reality when I hear, Um...my water just broke. I immediately jumped out of bed, flipped on the lights and said, Ok, Ill meet you at the hospital. Jamie said she was doing fine and she was going to get ready really quick and pack a bag. I told her to text me when she left for the hospital and I would meet her there. As soon as we hung up I called Curtis and woke him up with, Jamies water just broke! I thought for sure they would be able to stop delivery for at least 24 hours so ...
http://kimberlyvball7.blogspot.com/2013/04/team-babies-happy-birthday-april-9th.html?showComment=1365832890125
C+PLUS SERIES Ready To Wear Spring Summer 2019 New York - NOWFASHIONC+PLUS SERIES Ready To Wear Spring Summer 2019 New York - NOWFASHION
Discover NOWFASHION, the first real time fashion photography magazine to publish exclusive live fashion shows. Get to see the latest fashion runways in streaming!
https://nowfashion.com/c-plus-series-ready-to-wear-spring-summer-2019-new-york-25630
Protocols and Video Articles Authored by Xiao Yu WuProtocols and Video Articles Authored by Xiao Yu Wu
Xiao Yu Wu is the author of this article in the Journal of Visualized Experiments: Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice
https://www.jove.com/author/Xiao+Yu_Wu
Anal Cancer Treatment - Forum on AIDS-Related Cancers - TheBody.comAnal Cancer Treatment - Forum on AIDS-Related Cancers - TheBody.com
The standard treatment for anal cancer is a combination of chemotherapy (typically with 5-FU and mitomycin) and radiation. This has been the standard of care for well over a decade. In general,...
http://www.thebody.com/Forums/AIDS/Cancer/Q14173.html
corsair 1gb mmc - USB Flash Drives - Corsair Communitycorsair 1gb mmc - USB Flash Drives - Corsair Community
hey uhmm... i tried to use the corsair 1 gb mmc on my phone, samsung p735, but it doesnt work. my phone reads it but like it cant read the files in it and says theres not enough memory to take a picture ( even though in the memory status it says there is 1 gb of memory). could you help me?
https://forum.corsair.com/forums/topic/23062-corsair-1gb-mmc/
Well May was not my month! - BabyCenterWell May was not my month! - BabyCenter
I really didnt want to be posting this type of post in the group. I know it leads to a lot of worry for you mommas but I also feel like I need to acknowledge it as well. Went in today for my first u/s at 7w5d and she couldnt see anything with the abdominal u/s so she had me empty my bladder and we did the t/v u/s. We could see the sac but only a yolk sac -an oversized one at that and no fetal pole or anything. :( So guess it was a blighted ovum. She didnt actually use that term, she just called it a MMC. She gave me the option of a dnc or waiting it out. Not sure quite yet, I had a dnc in Aug 2009 after a MMC at 10 wk ( baby measured 8.5). This time, no baby! I had symptoms like fatigue and sore breasts but no major nausea and no vomiting. Im so thankful to have my healthy 3 yr old and will give her lots of extra hugs tonight. Best of luck to you ladies. I hope you have a healthy and happy 9 months and wishing you all adorable and gorgeous babies! Hopefully I can get to trying again in just a few
https://community.babycenter.com/post/a45241132/well_may_was_not_my_month
Off the Record w/ Ski Beatz (Video) | 2DOPEBOYZOff the Record w/ Ski Beatz (Video) | 2DOPEBOYZ
Continuing their Off the Record series thats featured the likes of TDEs MixedByAli, DJ Spinz and more, L-R-G catches up with the often over-looked Ski Beatz. In the clip above, Ski speaks on his early days as an emcee with Original Flavor, linking up with Jay-Z and more.. PREVIOUS: C Plus x Ski Beatz - The Extra Sessions (FreEP) , Curren$y Confirms Pilot Talk III with Ski Beatz. ...
https://2dopeboyz.com/2013/06/18/off-the-record-w-ski-beatz-video/
Search results | GTR ForumSearch results | GTR Forum
Short movie I made at Grobnik track (Croatia) on Tuesday. It was an insanely hot day, temp was around 38-40C plus humidity... It was my first time there so Im still learning the track and all my rounds were made in the GT-R as wife wouldnt let her X go (she was having too much fun). I dont ...
https://www.gtr.co.uk/tags/croatia/
Can the uterus still grow in a MMC? - BabyandBumpCan the uterus still grow in a MMC? - BabyandBump
Hi ladies, I just wanted to ask if any of you ladies have experienced a MMC where the uterus continued to grow? And can somebody tell me why this happens??? Is it common etc?? Thanking you in advance
http://babyandbump.momtastic.com/miscarriage-support/320120-can-uterus-still-grow-mmc.html
How to be potatopickle by Max C on PreziHow to be potatopickle by Max C on Prezi
Do you really want to delete this prezi? Neither you, nor the coeditors you shared it with will be able to recover it again. DeleteCancel ...
https://prezi.com/reygvjj7tbwx/how-to-be-potatopickle/
Mitomycin CMitomycin C
... is a mitomycin that is used as a chemotherapeutic agent by virtue of its antitumour activity. It is given ... Mitomycin is also used as a chemotherapeutic agent in glaucoma surgery. Pregnant women should not take mitomycin gel because it ... Subjects received mitomycin gel once a week (mitomycin gel 4 mg per mL instillations via ureteral catheter or nephrostomy tube ... Mitomycin C is a potent DNA crosslinker. A single crosslink per genome has shown to be effective in killing bacteria. This is ...
https://en.wikipedia.org/wiki/Mitomycin_C
MitomycinsMitomycins
They include mitomycin A, mitomycin B, and mitomycin C. When the name mitomycin occurs alone, it usually refers to mitomycin C ... Mitomycin C is used as a medicine for treating various disorders associated with the growth and spread of cells. In general, ... Mitomycin C is used to treat pancreatic and stomach cancer, and is under clinical research for its potential to treat ... "Mitomycin". Drugs.com. 2017. Retrieved 11 November 2017. Rustagi, T; Aslanian, H. R; Laine, L (2015). "Treatment of Refractory ...
https://en.wikipedia.org/wiki/Mitomycins
Nenitzescu indole synthesisNenitzescu indole synthesis
Allen, G.; Pidacks, C.; Weiss, M. (5 June 1996). "The Mitomycin Antibiotics. Synthetic Studies". J. Am. Chem. Soc. 88 (11): ...
https://en.wikipedia.org/wiki/Nenitzescu_indole_synthesis
Pterygium (eye)Pterygium (eye)
The additional use of mitomycin C is of unclear effect. Radiotherapy has also been used in an attempt to reduce the risk of ... "Mitomycin C in pterygium treatment". International Journal of Ophthalmology. 9 (3): 465-8. doi:10.18240/ijo.2016.03.25. PMC ...
https://en.wikipedia.org/wiki/Pterygium_(eye)
Santosh G. HonavarSantosh G. Honavar
"Mitomycin-C in congenital glaucoma". Ophthalmic Surg Lasers. 28 (12): 979-85. doi:10.3928/1542-8877-19971201-03. PMID 9427984 ...
https://en.wikipedia.org/wiki/Santosh_G._Honavar
CalicheamicinCalicheamicin
... and mitomycin". Chemical Reviews. 105 (2): 739-58. doi:10.1021/cr030117g. PMID 15700963. Zhang, C; Griffith, BR; Fu, Q; ...
https://en.wikipedia.org/wiki/Calicheamicin
AryneAryne
... and mitomycin". Chemical Reviews. 105 (2): 739-58. doi:10.1021/cr030117g. PMID 15700963. Kametani, T.; Ogasawara, K. J. J. Chem ...
https://en.wikipedia.org/wiki/Aryne
Streptomyces caespitosusStreptomyces caespitosus
It produces chemotherapeutic drug mitomycin C. Sugawara R, Hata T (1956). ""Mitomycin, a new antibiotic from Streptomyces. II. ...
https://en.wikipedia.org/wiki/Streptomyces_caespitosus
Photorefractive keratectomyPhotorefractive keratectomy
De Benito-Llopis, L; Teus, MA; Sánchez-Pina, JM (2008). "Comparison between LASEK with mitomycin C and LASIK for the correction ... "Long-term concerns linger on safety of Mitomycin-C". Archived from the original on November 3, 2013. Retrieved April 22, 2013 ... Mitomycin C worsens post-surgical dry eye. PRK may be performed on one eye at a time to assess the results of the procedure and ... Mitomycin-C, can be applied briefly at the completion of surgery to reduce risk of hazing, although with increased risk of ...
https://en.wikipedia.org/wiki/Photorefractive_keratectomy
ChemotherapyChemotherapy
This occurs when bleomycin binds to a metal ion, becomes chemically reduced and reacts with oxygen.: 87 Mitomycin is a ... Verweij J, Pinedo HM (October 1990). "Mitomycin C: mechanism of action, usefulness and limitations". Anti-Cancer Drugs. 1 (1): ... The most important subgroup is the anthracyclines and the bleomycins; other prominent examples include mitomycin C and ... mitomycin C, anthracyclines, BCNU, melphalan) including CDDP could be reversed at least partially by the addition of heat. ...
https://en.wikipedia.org/wiki/Chemotherapy
Streptomyces michiganensisStreptomyces michiganensis
... produces actinomycin X, antipain and mitomycin. Xue, Jinghua; Wu, Min (27 March 2015). "Cyclic ... Wolf, Gudrun; Wörth, Jürgen; Achenbach, Hans (1975). "Mitomycin und ein neues Phenoxazon-Pigment aus Streptomyces michiganensis ... "Mitomycin und ein neues Phenoxazon-Pigment aus Streptomyces michiganensis". Archives of Microbiology. 106 (3): 245-249. doi: ...
https://en.wikipedia.org/wiki/Streptomyces_michiganensis
AziridinesAziridines
Binary ethylenimine, a dimeric form of aziridine Tomasz, Maria (September 1995). "Mitomycin C: small, fast and deadly (but very ... Several drugs feature aziridine rings, including mitomycin C, porfiromycin, and azinomycin B (carzinophilin). The bond angles ...
https://en.wikipedia.org/wiki/Aziridines
Immunosuppressive drugImmunosuppressive drug
Other cytotoxic antibiotics are anthracyclines, mitomycin C, bleomycin, mithramycin. Antibodies are sometimes used as a quick ...
https://en.wikipedia.org/wiki/Immunosuppressive_drug
Aaron Frederick Rasmussen Jr.Aaron Frederick Rasmussen Jr.
Nayak, D.P.; Rasmussen Jr., A.F. (1966). "Influence of mitomycin C on the replication of influenza viruses". Virology. 30 (4): ...
https://en.wikipedia.org/wiki/Aaron_Frederick_Rasmussen_Jr.
TrabeculectomyTrabeculectomy
Marey, H M; S S Mandour; A F Ellakwa (Oct 2012). "Subscleral Trabeculectomy with Mitomycin-C Versus Ologen for Treatment of ... "A prospective randomised trial of trabeculectomy using mitomycin C vs an ologen implant in open angle glaucoma". Eye. 24 (9): ... "Biodegradable collagen matrix implant vs mitomycin-C as an adjuvant in trabeculectomy: a 24-month, randomized clinical trial". ... is created under the conjunctiva and Tenon's capsule and the wound bed is treated for several seconds to minutes with mitomycin ...
https://en.wikipedia.org/wiki/Trabeculectomy
ParaxanthineParaxanthine
... average birth weight decreased significantly in mice exposed to caffeine or theophylline when coadministered with mitomycin C, ... but not for paraxanthine coadministered with mitomycin C. Paraxanthine was reported to be significantly less clastogenic ... "Potentiating effects of methylxanthines on teratogenicity of mitomycin C in mice". Teratology. 28 (2): 243-247. doi:10.1002/ ...
https://en.wikipedia.org/wiki/Paraxanthine
ERCC1ERCC1
These polymorphisms may have differential effects on platinum and mitomycin damage. ERCC1 protein expression is reduced or ...
https://en.wikipedia.org/wiki/ERCC1
Glaucoma surgeryGlaucoma surgery
"Surgical outcome of mitomycin C-soaked collagen matrix implant in trabeculectomy". J Glaucoma. 22 (6): 456-62. doi:10.1097/IJG. ...
https://en.wikipedia.org/wiki/Glaucoma_surgery
Bleb (medicine)Bleb (medicine)
730-736 Yuan F, Li L, Chen X, Yan X, Wang L (2015). "Biodegradable 3D-Porous Collagen Matrix (Ologen) Compared with Mitomycin C ... "Surgical outcome of mitomycin C-soaked collagen matrix implant in trabeculectomy". J Glaucoma. 22 (6): 456-62. doi:10.1097/ijg. ...
https://en.wikipedia.org/wiki/Bleb_(medicine)
Glaucoma valveGlaucoma valve
A Cochrane Review comparing aqueous shunt surgery with and without Mitomycin-C did not find benefit or harm associated with the ... 2014). "Using a collagen matrix implant (Ologen) versus mitomycin-C as a wound healing modulator in trabeculectomy with the Ex- ... Foo VH, Htoon HM, Welsbie DS, Perera SA (2019). "Aqueous shunts with mitomycin C versus aqueous shunts alone for glaucoma". ... This may require preventive measures using anti-fibrotic medication like 5-fluorouracil (5FU) or Mitomycin-C (during the ...
https://en.wikipedia.org/wiki/Glaucoma_valve
YingchengvirusYingchengvirus
Upon mitomycin C induction, large amounts of SNJ1 virions can be produced. SNJ1 genome replicates by the rolling-circle ...
https://en.wikipedia.org/wiki/Yingchengvirus
Cochrane Eyes and VisionCochrane Eyes and Vision
Cabourne, Emily; Clarke, Jonathan C. K.; Schlottmann, Patricio G.; Evans, Jennifer R. (2015-11-06). "Mitomycin C versus 5- ...
https://en.wikipedia.org/wiki/Cochrane_Eyes_and_Vision
Hyperthermic intraperitoneal chemotherapyHyperthermic intraperitoneal chemotherapy
Mitomycin C and oxaliplatin are the most commonly used agent for colorectal cancer, while cisplatin is used in ovarian cancer. ... The chemotherapeutic agents generally infused during IPHC are mitomycin-C and cisplatin. IPHC is generally used after surgical ...
https://en.wikipedia.org/wiki/Hyperthermic_intraperitoneal_chemotherapy
Emulsion stabilization using polyelectrolytesEmulsion stabilization using polyelectrolytes
Unerberg, W. J. M.; Lingeman, H. (1983). "Determination of pKa Values of Some Prototropic Function in Mitomycin and ...
https://en.wikipedia.org/wiki/Emulsion_stabilization_using_polyelectrolytes
FANCGFANCG
... , involved in Fanconi anemia, confers resistance to both hygromycin B and mitomycin C. FANCG contains a 5-prime GC-rich ... Kruyt FA, Abou-Zahr F, Mok H, Youssoufian H (November 1999). "Resistance to mitomycin C requires direct interaction between the ... "Reduced fertility and hypersensitivity to mitomycin C characterize Fancg/Xrcc9 null mice". Hum. Mol. Genet. 11 (3): 273-81. doi ...
https://en.wikipedia.org/wiki/FANCG
GlaucomaGlaucoma
Yuan F, Li L, Chen X, Yan X, Wang L (2015). "Biodegradable 3D-Porous Collagen Matrix (Ologen) Compared with Mitomycin C for ... Traditionally, chemotherapeutic adjuvants, such as mitomycin C (MMC) or 5-fluorouracil (5-FU), are applied with soaked sponges ... This may require preventive measures using antifibrotic medications, such as 5-fluorouracil or mitomycin-C (during the ... "Biodegradable collagen matrix implant versus mitomycin-C in trabeculectomy: five-year follow-up". BMC Ophthalmology. 16 (24): ...
https://en.wikipedia.org/wiki/Glaucoma
Intravenous ascorbic acidIntravenous ascorbic acid
1995). "Mitomycin C and menadione for the treatment of lung cancer: a phase II trial". Investigational New Drugs. 13 (2): 157- ... 1995). "Phase I study of mitomycin C and menadione in advanced solid tumors". Cancer Chemotherapy and Pharmacology. 36 (4): 293 ...
https://en.wikipedia.org/wiki/Intravenous_ascorbic_acid
Streptomyces lavendulaeStreptomyces lavendulae
Mitomycins and porfiromycin: chemical mechanism of activation and cross-linking of DNA. Science. 145:55-56. August PR, Rahn JA ... Inducible synthesis of Mitomycin C resistance gene product (MCRA) from Streptomyces lavendulae. Gene: An International Journal ... Mitomycin Resistance in Streptomyces lavendulae Includes a Novel Drug-Binding-Protein-Dependent Export System. Journal of ... Characterization of a Mitomycin-Binding Drug Resistance Mechanism from the Producing Organism, Streptomyces lavendulae. Journal ...
https://en.wikipedia.org/wiki/Streptomyces_lavendulae
Bladder cancerBladder cancer
The two most common medicines used for this purpose are Bacillus Calmette-Guérin (BCG) and mitomycin. For people who have ... Di Stasi SM, Riedl C (June 2009). "Updates in intravesical electromotive drug administration of mitomycin-C for non-muscle ... Medications which can used for this purpose are mitomycin C (MMC), epirubicin, pirarubicin and gemcitabine. Instillation of ... Radiation sensitizing chemotherapy regimens consisting of cisplatin or 5-flurouracil and mitomycin C are used. Radiation ...
https://en.wikipedia.org/wiki/Bladder_cancer
Streptococcus pneumoniaeStreptococcus pneumoniae
Transformation protects S. pneumoniae against the bactericidal effect of mitomycin C. Michod et al. summarized evidence that ... pneumoniae is induced by DNA-damaging agents such as mitomycin C, fluoroquinolone antibiotics (norfloxacin, levofloxacin and ...
https://en.wikipedia.org/wiki/Streptococcus_pneumoniae
Mitomycin: MedlinePlus Drug InformationMitomycin: MedlinePlus Drug Information
Mitomycin: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Before receiving mitomycin,. *tell your doctor and pharmacist if you are allergic to mitomycin, any other medications, or any ... Mitomycin comes as a powder to be mixed with liquid and injected intravenously (into a vein) by a doctor or nurse in a medical ... Mitomycin is a type of antibiotic that is only used in cancer chemotherapy. It slows or stops the growth of cancer cells in ...
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Mitomycin C Injections Reduce Eye Pressure After SurgeryMitomycin C Injections Reduce Eye Pressure After Surgery
Mitomycin C administered by injection during trabeculectomy improves outcomes with fewer complications, a new study shows. ... "Mitomycin C injection is a real advance for us," session cochair Joel Schuman, MD, from the University of Pittsburgh in ... "Our study suggests that mitomycin C injection leads to a reduction in medication use after surgery, and results in fewer tense ... Her research team reviewed the outcomes of trabeculectomy in which mitomycin C was used. In 57 eyes, physicians used a sponge ...
http://www.medscape.com/viewarticle/781548
DailyMed - MITOMYCIN C powderDailyMed - MITOMYCIN C powder
MITOMYCIN (UNII: 50SG953SK6) (MITOMYCIN - UNII:50SG953SK6) MITOMYCIN. 1 g in 1 g. ... MITOMYCIN C powder. Out of scope - Out of scope for RxNorm and will not receive RxNorm normal forms. Out of scope information ... MITOMYCIN C powder. If this SPL contains inactivated NDCs listed by the FDA initiated compliance action, they will be specified ... MITOMYCIN C powder. To receive this label RSS feed. Copy the URL below and paste it into your RSS Reader application. https:// ...
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Diagnosis of Fanconi Anaemia by ionising radiation- or mitomycin C-induced micronucleiDiagnosis of Fanconi Anaemia by ionising radiation- or mitomycin C-induced micronuclei
... associated with chromosomal instability and cellular hypersensitivity to DNA cross-linking agents such as mitomycin C (MMC). ... Diagnosis of Fanconi Anaemia by ionising radiation- or mitomycin C-induced micronuclei DNA Repair (Amst). 2018 Jan;61:17-24. ... associated with chromosomal instability and cellular hypersensitivity to DNA cross-linking agents such as mitomycin C (MMC). ...
https://pubmed.ncbi.nlm.nih.gov/29154021/
History, presence, and future of mitomycin C in glaucoma fil... : Current Opinion in OphthalmologyHistory, presence, and future of mitomycin C in glaucoma fil... : Current Opinion in Ophthalmology
Mitomycin C (MMC) is an alkylating agent with extraordinary ability to crosslin ... History, presence, and future of mitomycin C in glaucoma filtration surgery. Wolters, Jarno E.J.a,b,c; van Mechelen, Ralph J.S. ... Mitomycin C (MMC) is an alkylating agent with extraordinary ability to crosslink DNA, preventing DNA synthesis. By this virtue ... History, presence, and future of mitomycin C in glaucoma filtration surgery : Current Opinion in Ophthalmology. ...
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Mitomycin - Drug Info, Side Effects, Research, Clinical TrialsMitomycin - Drug Info, Side Effects, Research, Clinical Trials
MITOMYCIN SUMMARY Mitomycin (also known as mitomycin and/or mitomycin-C) is an antibiotic isolated from the broth of ... Each vial contains either mitomycin 5 mg and mannitol 10 mg, or mitomycin 20 mg and mannitol 40 mg, or mitomycin 40 mg and ... Study of Mitomycin C and Nasal Splint to Treat Nasal Synechiae [Completed]. This study evaluates whether Mitomycin C is an ... MITOMYCIN is indicated for the following:. Mitomycin for Injection is not recommended as single-agent, primary therapy. It has ...
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Mitomycin - Side Effects, Precautions, and ContraindicationsMitomycin - Side Effects, Precautions, and Contraindications
Mitomycin can cause side effects such as nausea and vomitting. Inform your doctor if you experience sore throat, hoarseness or ... Mitomycin - Side Effects, Precautions, and Contraindications. What side effects can Mitomycin cause?. Early side effects ... Mitomycin - Handling. How should I handle Mitomycin safely?. Mitomycin - Storage. How should I store Mitomycin ?. ...
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Immediate Post-TURBT Mitomycin C Reduces NMIBC Recurrence Risk - Renal and Urology NewsImmediate Post-TURBT Mitomycin C Reduces NMIBC Recurrence Risk - Renal and Urology News
Instilling mitomycin C within 24 hours of TURBT vs after 2 weeks was associated with a 27% lower risk of recurrence. ... Early mitomycin C was associated with a 27% reduction in recurrence risk and also improved time to recurrence. ... Value of an immediate intravesical instillation of mitomycin C in patients with non-muscle-invasive bladder cancer: A ... Close more info about Immediate Post-TURBT Mitomycin C Reduces NMIBC Recurrence Risk ...
https://www.renalandurologynews.com/home/news/urology/bladder-cancer/immediate-post-turbt-mitomycin-c-reduces-nmibc-recurrence-risk/
Topical mitomycin in endoscopic-assisted probing for the treatment of congenital nasolacrimal duct obstruction in older childrenTopical mitomycin in endoscopic-assisted probing for the treatment of congenital nasolacrimal duct obstruction in older children
We compared children who underwent endoscopic-assisted probing with mitomycin C (mitomycin C group) versus others who underwent ... The success rates were high in both groups ( p,0.05). There were no adverse events related to the use of mitomycin C (p,0.05). ... Purpose: Mitomycin C has been used in ophthalmic surgery to mitigate postoperative scarring. However, the outcomes of ... Topical mitomycin in endoscopic-assisted probing for the treatment of congenital nasolacrimal duct obstruction in older ...
https://repositorio.unesp.br/handle/11449/196944
BlackBoxRX • MitomycinBlackBoxRX • Mitomycin
Mitomycin for injection should be administered under the supervision of a qualified physician experienced in the use of cancer ... The syndrome may occur at any time during systemic therapy with mitomycin as a single agent or in combination with other ... and irreversible renal failure has been reported in patients receiving systemic mitomycin. ... cytotoxic drugs, however, most cases occur at doses ?60 mg of mitomycin. Blood product transfusion may exacerbate the symptoms ...
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Nine-year follow-up of trabeculectomy with or without low-dosage mitomycin-c in primary open-angle glaucoma | British Journal...Nine-year follow-up of trabeculectomy with or without low-dosage mitomycin-c in primary open-angle glaucoma | British Journal...
Aim: To evaluate the long-term efficacy and safety of trabeculectomy with or without low-dosage Mitomycin-C (MMC) in primary ... Nine-year follow-up of trabeculectomy with or without low-dosage mitomycin-c in primary open-angle glaucoma ... Nine-year follow-up of trabeculectomy with or without low-dosage mitomycin-c in primary open-angle glaucoma ...
https://bjo.bmj.com/content/92/12/1666
Eradication of Biofilm-Like Microcolony Structures of Borrelia burgdorferi by Daunomycin and Daptomycin but not Mitomycin C in...Eradication of Biofilm-Like Microcolony Structures of Borrelia burgdorferi by Daunomycin and Daptomycin but not Mitomycin C in...
Mitomycin C in combination with doxycycline and cefuroxime caused no regrowth at 7 days but visible spirochetal regrowth ... Eradication of Biofilm-Like Microcolony Structures of Borrelia burgdorferi by Daunomycin and Daptomycin but not Mitomycin C in ... Recent studies identified several drug candidates including daptomycin, daunomycin, doxorubicin, and mitomycin C that had good ... Our findings demonstrate daunomycin and daptomycin were more active than mitomycin C in single drug comparison at 10 and 20 μM ...
https://canlyme.com/2016/02/17/eradication-of-biofilm-like-microcolony-structures-of-borrelia-burgdorferi-by-daunomycin-and-daptomycin-but-not-mitomycin-c-in-combination-with-doxycycline-and-cefuroxime/
Transarterial chemoembolization (TACE) using mitomycin and lipiodol with or without degradable starch microspheres for...Transarterial chemoembolization (TACE) using mitomycin and lipiodol with or without degradable starch microspheres for...
The administered chemotherapeutic agent included mitomycin. For embolization, lipiodol only (n = 51;51.5%; mean age 63.8  ... From: Transarterial chemoembolization (TACE) using mitomycin and lipiodol with or without degradable starch microspheres for ...
https://bmccancer.biomedcentral.com/articles/10.1186/s12885-018-4099-x/tables/2
Mitomycin (2mg) - Cancer PharmaciesMitomycin (2mg) - Cancer Pharmacies
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Resveratrol Enhances Mitomycin C-mediated Suppression of Human Colorectal Cancer Cell Proliferation by Up-regulation of p21WAF1...Resveratrol Enhances Mitomycin C-mediated Suppression of Human Colorectal Cancer Cell Proliferation by Up-regulation of p21WAF1...
Mitomycin C instillation following ureterorenoscopic laser ablation of upper urinary tract carcinoma. Urol Ann 5: 184-189, 2013 ... Mitomycin in anal cancer: still the standard of care. J Clin Oncol 30: 4297-4301, 2012. ... Resveratrol Enhances Mitomycin C-mediated Suppression of Human Colorectal Cancer Cell Proliferation by Up-regulation of p21WAF1 ... A phase II study of mitomycin C and oral etoposide for advanced adenocarcinoma of the upper gastrointestinal tract. Ann Oncol 8 ...
https://ar.iiarjournals.org/content/34/10/5439.full
Anal carcinoma therapy: Can we improve on 5-fluorouracil/mitomycin/ radiotherapy?<...
Anal carcinoma therapy: Can we improve on 5-fluorouracil/mitomycin/ radiotherapy? JNCCN Journal of the National Comprehensive ... Jiang, Y., Mackley, H., Cheng, H., & Ajani, J. A. (2010). Anal carcinoma therapy: Can we improve on 5-fluorouracil/mitomycin/ ... Anal carcinoma therapy: Can we improve on 5-fluorouracil/mitomycin/ radiotherapy?. Yixing Jiang, Heath Mackley, Hua Cheng, ... Anal carcinoma therapy : Can we improve on 5-fluorouracil/mitomycin/ radiotherapy?. In: JNCCN Journal of the National ...
https://pennstate.pure.elsevier.com/en/publications/anal-carcinoma-therapy-can-we-improve-on-5-fluorouracilmitomycin-
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IMSEAR at SEARO: Intravesical adjuvant therapy using mitomycin C.
Intravesical adjuvant therapy using mitomycin C. Mymensingh Medical Journal. 2006 Jan; 15(1): 40-4. ... to observe the efficacy of intravesical adjuvant therapy with single immediate versus delayed multi-dose regimen of Mitomycin C ...
https://imsear.searo.who.int/handle/123456789/1082
Multiphoton imaging of rabbit cornea treated with mitomycin C after photorefractive keratectomy<...
Hsueh, C. M., Lo, W., Wang, T-J., Hu, F. R., & Dong, C. Y. (2007). Multiphoton imaging of rabbit cornea treated with mitomycin ... Hsueh, CM, Lo, W, Wang, T-J, Hu, FR & Dong, CY 2007, Multiphoton imaging of rabbit cornea treated with mitomycin C after ... 深入研究「Multiphoton imaging of rabbit cornea treated with mitomycin C after photorefractive keratectomy」主題。共同形成了獨特的指紋。 ... Multiphoton imaging of rabbit cornea treated with mitomycin C after photorefractive keratectomy. / Hsueh, Chiu Mei; Lo, Wen; ...
https://tmu.pure.elsevier.com/zh/publications/multiphoton-imaging-of-rabbit-cornea-treated-with-mitomycin-c-aft
50 Mitomycin - Bladdergraffiti50 Mitomycin - Bladdergraffiti
50 Mitomycin. Date: January 29, 2021Author: bladdergraffiti - bladder blogging - a journey with bladder cancer 6 Comments ... Wednesday 27 January was the 50th dose of Mitomycin Ive had over the last 5 years! The eighth with EMDA. I wasnt looking ... It amazes me still the precautions that they take when handling mitomycin or rather NOT handling it:. *plastic sheeting with a ... Since then Ive had treatment with Mitomycin C and several recurrences. Latest recurrence October 2022 TaG1 (x3) and cis. New ...
https://bladdergraffiti.com/2021/01/29/50-mitomycin/
Mitomycin CMitomycin C
Posts about Mitomycin C written by Bentham Science Publishers ... Tag: Mitomycin C. Testimonial By Nasim Sarrami. Read what our ... Contributed Article: LHRH Targeted Chonderosomes Of Mitomycin C In Breast Cancer: An In Vitro/ In Vivo Study ... Mitomycin C, TestimonialLeave a comment on Testimonial By Nasim Sarrami ...
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Clinical effects of intra-arterial infusion chemotherapy with cisplatin, mitomycin C, leucovorin and 5-flourouracil for...
Clinical effects of intra-arterial infusion chemotherapy with cisplatin, mitomycin C, leucovorin and 5-flourouracil for ... Clinical effects of intra-arterial infusion chemotherapy with cisplatin, mitomycin C, leucovorin and 5-flourouracil for ...
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Urothelial Tumors of the Renal Pelvis and Ureters Medication: Antineoplastics, Antibiotic, Biological Response Modifiers,...Urothelial Tumors of the Renal Pelvis and Ureters Medication: Antineoplastics, Antibiotic, Biological Response Modifiers,...
Mitomycin is an alkylating drug isolated from the broth of Streptomyces caespitosus. It inhibits DNA synthesis. At high ... Mitomycin selectively inhibits DNA synthesis. At high concentrations of the drug, cellular RNA and protein synthesis are also ... Adjuvant mitomycin C following endoscopic treatment of upper tract transitional cell carcinoma. J Urol. 1997 Dec. 158(6):2074-7 ... Jelmyto (mitomycin) [package insert]. Princeton, NJ: UroGen Pharma, Inc. April 2020. Available at [Full Text]. ...
https://emedicine.medscape.com/article/452449-medication
Mitomycin C Topical Application - LaryngopediaMitomycin C Topical Application - Laryngopedia
Mitomycin C topical application is the use of the medication Mitomycin C to prevent post-procedural scarring in the larynx or ... Mitomycin C Topical Application. Mitomycin C topical application is the use of the medication Mitomycin C to prevent post- ... A common way to apply Mitomycin C would be to take the drug in dilute form (e.g., 0.3mg per ml), saturate a cottonoid sponge ... Mitomycin Cs mechanism of action is reported to be absorption of the drug by fibroblasts, which are then "decommissioned" from ...
https://laryngopedia.com/mitomycin-c/
mitomycin C QuickView - Correlation Engine
A Study of Mitomycin C, Irinotecan, and Cetuximab. *Surgery and Oxaliplatin or Mitomycin C in Treating Patients With Tumors of ... Mitomycin C With Hyperthermia and Intravesical Mitomycin C to Treat Recurrent Bladder Cancer ... The effectiveness of mitomycin C in Otolaryngology procedures: A systematic review. * Cytotoxicity, crosslinking and biological ... Transcription of DNA-Methyltransferases in Endothelial Cells Exposed to Mitomycin C]. * One-Year Randomized Comparison of ...
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Registration Dossier - ECHARegistration Dossier - ECHA
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NMAM 5th Edition - Methods by Number | NIOSH | CDCNMAM 5th Edition - Methods by Number | NIOSH | CDC
Mitomycin C. 0501. PARTICULATES N.O.R., Total. 1453. VINYL ACETATE. 2005. NITROAROMATIC COMPOUNDS. ...
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Trabeculectomy with brief exposure of mitomycin C | AVESİSTrabeculectomy with brief exposure of mitomycin C | AVESİS
In this study, mitomycin-C (MMC) al a concentration of 0.2 mg/mL was applied intraoperatively for 1 minute in 11 consecutive ...
https://avesis.medeniyet.edu.tr/yayin/78fa4c62-f393-423d-8c6e-183f71648335/trabeculectomy-with-brief-exposure-of-mitomycin-c
ChemotherapyHemolytic uremic sDoxorubicinIntravesicalInjectionAntibioticTrabeculectomyGemcitabineInstillationRecurrenceCisplatinBladderIntraoperativeTumorCONCLUSIONS0.042000SystemicCapecitabineVialTopical applicationCell ProliferationPterygiumMicronucleiEfficacyPrecautionsVersusInjectionsSpongeGlaucomaTreatmentOphthalmicRadiotherapyFibrosisSynthesisCombinationDrugEvaluationQualified physicianSafelySeverePowderPharmaciesTechniquePurposeEffects
Chemotherapy8
  • Mitomycin injection must be given in a hospital or medical facility under the supervision of a doctor who is experienced in giving chemotherapy medications for cancer. (medlineplus.gov)
  • Mitomycin is a type of antibiotic that is only used in cancer chemotherapy. (medlineplus.gov)
  • Hemolytic Uremic Syndrome (HUS) a serious complication of chemotherapy, consisting primarily of microangiopathic hemolytic anemia, thrombocytopenia, and irreversible renal failure has been reported in patients receiving systemic mitomycin. (druglib.com)
  • For non-muscle-invasive bladder cancer (NMIBC) patients undergoing transurethral resection of bladder tumor (TURBT), instilling mitomycin C chemotherapy within 24 hours reduces the risk of recurrence compared with delaying it by 2 weeks, according to a new study. (renalandurologynews.com)
  • The current study was designed to assess the capacity of a widely used natural product, resveratrol (RV), to increase the effectiveness of a chemotherapy agent, mitomycin C (MMC), in inhibiting the proliferation of human colorectal cancer cells. (iiarjournals.org)
  • Clinical effects of intra-arterial infusion chemotherapy with cisplatin, mitomycin C, leucovorin and 5-flourouracil for unresectable advanced hepatocellular carcinoma. (uams.edu)
  • Most commonly used chemotherapy agents are mitomycin and gemcitabine. (medscape.com)
  • Outside the field of laryngology, Mitomycin C is used more commonly as a cancer chemotherapy agent, but within laryngology, Mitomycin C is often applied by a clinician to prevent scarring after procedures like laryngeal or tracheal dilation or division of a glottic web . (laryngopedia.com)
Hemolytic uremic s1
  • Mitomycin may cause hemolytic uremic syndrome (a potentially life-threatening condition that involves injury to red blood cells, causing anemia and kidney problems). (medlineplus.gov)
Doxorubicin3
  • Recent studies identified several drug candidates including daptomycin, daunomycin, doxorubicin, and mitomycin C that had good activity against B. burgdorferi persisters. (canlyme.com)
  • The mitotic chromosomes from the gills of the fish Boleophthalmus dussumieri were studied for the induction of chromosomal aberrations after in vivo treatments with three separate antineoplastic antibiotics: Bleomycin (radiomimetic drug), Mitomycin-C (bifunctional alkylating agent) and Doxorubicin (intercalating agent). (indjst.org)
  • The concentration doses of Bleomycin (150µg and 300µg), Mitomycin-C (1 µg, 2 µg and 4 µg) and Doxorubicin (10 µg, 20 µg and 40 µg) were decided on the basis of the body weight of fishes and earlier laboratory findings. (indjst.org)
Intravesical6
  • Our aim was to compare TURBT alone with immediate post-TURBT intravesical passive diffusion (PD) of mitomycin and immediate pre-TURBT intravesical electromotive drug administration (EMDA) of mitomycin in non-muscle invasive bladder cancer. (druglib.com)
  • moreover, it reduces recurrence rates and enhances the disease-free interval compared with intravesical PD mitomycin after TURBT and TURBT alone. (druglib.com)
  • V alue of an immediate intravesical instillation of mitomycin C in patients with non-muscle-invasive bladder cancer: A prospective multicentre randomised study in 2243 patients . (renalandurologynews.com)
  • IMSEAR at SEARO: Intravesical adjuvant therapy using mitomycin C. (who.int)
  • A study was carried out to observe the efficacy of intravesical adjuvant therapy with single immediate versus delayed multi-dose regimen of Mitomycin C (MMC) in preventing recurrence of superficial bladder cancer. (who.int)
  • Like BCG intravesical, this formulation of mitomycin is for intravesical use. (medscape.com)
Injection14
  • Your doctor will order certain tests before and during your treatment to see if it is safe for you to receive mitomycin injection and to check your body's response to mitomycin injection. (medlineplus.gov)
  • It is important for you to tell your doctor how you are feeling during your treatment with mitomycin injection. (medlineplus.gov)
  • tell your doctor and pharmacist if you are allergic to mitomycin, any other medications, or any of the ingredients in mitomycin injection. (medlineplus.gov)
  • Your doctor may not want you to receive mitomycin injection. (medlineplus.gov)
  • SAN FRANCISCO, California - In patients with glaucoma, mitomycin C administered with intra-Tenon injection results in lower intraocular pressure and fewer medications after surgery than mitomycin C administered with a sponge, according to new research. (medscape.com)
  • Our study suggests that mitomycin C injection leads to a reduction in medication use after surgery, and results in fewer tense or encapsulated blebs," said Michele Lim, MD, from the UC Davis Eye Center in Sacramento, California. (medscape.com)
  • Mitomycin C injection is a real advance for us. (medscape.com)
  • Mitomycin C injection is a real advance for us," session cochair Joel Schuman, MD, from the University of Pittsburgh in Pennsylvania, told Medscape Medical News . (medscape.com)
  • The injection method "saves a significant amount of time, about 2 to 5 minutes per case," Dr. Schuman explained, improves outcomes, and "reduces exposure of operating room staff to mitomycin C. (medscape.com)
  • The lowest price on PharmacyChecker.com for mitomycin 10 mg is $34.80 per injection for 10 injections at PharmacyChecker-accredited online pharmacies. (pharmacychecker.com)
  • Mitomycin for Injection is a sterile dry mixture of mitomycin and mannitol, which when reconstituted with Sterile Water for Injection provides a solution for intravenous administration. (druglib.com)
  • Mitomycin for Injection is not recommended as single-agent, primary therapy. (druglib.com)
  • This patient has been managed with systemic medication, but also occasional dilation, steroid injection, and Mitomycin C application. (laryngopedia.com)
  • A week after that simple endoscopic division of the web, steroid injection, and topical mitomycin C application. (laryngopedia.com)
Antibiotic1
  • Mitomycin (also known as mitomycin and/or mitomycin-C) is an antibiotic isolated from the broth of Streptomyces caespitosus which has been shown to have antitumor activity. (druglib.com)
Trabeculectomy3
  • Her research team reviewed the outcomes of trabeculectomy in which mitomycin C was used. (medscape.com)
  • To evaluate the long-term efficacy and safety of trabeculectomy with or without low-dosage Mitomycin-C (MMC) in primary open-angle glaucoma (POAG). (bmj.com)
  • The purpose of this study was to report a case of neovascularization of angle (NVA) following trabeculectomy with mitomycin-c (MMC) in a patient with primary open-angle glaucoma. (ojoonline.org)
Gemcitabine3
  • In patients who had received oxaliplatin or in patients with other cancers the investigators will use mitomycin and gemcitabine together with capecitabine. (clinicaltrials.gov)
  • Mitomycin + Gemcitabine intrahepatic together with Capecitabine. (clinicaltrials.gov)
  • the agents most commonly used for this purpose are gemcitabine and mitomycin-C (see Chemotherapeutic Agents, below). (medscape.com)
Instillation1
  • Electromotive instillation of mitomycin immediately before transurethral resection for patients with primary urothelial non-muscle invasive bladder cancer: a randomised controlled trial. (druglib.com)
Recurrence4
  • Instilling mitomycin C within 24 hours of TURBT vs after 2 weeks was associated with a 27% lower risk of recurrence. (renalandurologynews.com)
  • Early mitomycin C was associated with a 27% reduction in recurrence risk and also improved time to recurrence. (renalandurologynews.com)
  • This study was designed to evaluate the results of intraoperative use of Mitomycin C in patients with single recurrence of pterygium. (msjonline.org)
  • 30 eyes of 30 patients who had single recurrence of pterygium after excision underwent pterygium excision along-with concurrent use of intraoperative 0.04% Mitomycin C. Postoperative follow up was done for a period of 6 months. (msjonline.org)
Cisplatin1
  • in one of the trials, use of cisplatin-based chemoradiation resulted in a higher rate of colostomy compared with mitomycin-based chemoradiation. (elsevier.com)
Bladder2
  • Mitomycin is also sometimes used intravesically (infused directly into the bladder) to treat bladder cancer. (medlineplus.gov)
  • We hear from Professor Jørgen Bjerggaard Jensen, who leads clinical research in bladder cancer at the Department of Urology, Aarhus University Hospital, as he explores the management of NMIBC through the neoadjuvant use of Mitomycin C (MMC). (emjreviews.com)
Intraoperative4
  • To evaluate the safety and efficacy of augmenting conjunctival autografting with intraoperative mitomycin C (MMC) application versus Ologen implantation in the management of recurrent pterygium . (bvsalud.org)
  • Intraoperative use of Mitomycin C in treatment of recurrent pterygium is safe and effective procedure. (msjonline.org)
  • Verma N, Garap JA, Maris R, Kerek A. Intraoperative use of mitomycin C in the treatment of recurrent pterygium. (msjonline.org)
  • Demirok A, Simsek S, Cinal A, Yasar T. Intraoperative application of mitomycin C in the surgical treatment of pterygium. (msjonline.org)
Tumor1
  • MMC is one of the families of mitomycins considered as anti-tumor antibiotics because of their capacity to inhibit bacterial DNA synthesis. (iiarjournals.org)
CONCLUSIONS1
  • Conclusions: Although mitomycin C has no adverse effects when applied to the opening of the nasolacrimal duct, its use after lacrimal probing for the treatment of congenital nasolacrimal duct obstruction does not improve the chance of success. (unesp.br)
0.041
  • Changes in the expression of immunofluorescent staining of kinetochore were determined to investigate a possible mechanism for micronuclei formation using human antikinetochore primary antibodies and fluoresceinated goat antihuman immunoglobulin-G. Vincristine- sulfate at 0.01microg/ml and mitomycin-C (MMC) at 0.04microg/ml were used as positive controls. (cdc.gov)
20002
  • [2] Because of the genetic defect in DNA repair, cells from people with FA are sensitive to drugs that treat cancer by DNA crosslinking , such as mitomycin C . The typical age of death was 30 years in 2000. (wikipedia.org)
  • El Grupo de Expertos Independientes en teléfonos Móviles (2000), sin embargo, declara en su informe que: ' En general los estudios reportan un aumento moderado de la actividad ODC sólo a frecuencias moduladas de cerca de 10-60 Hz. (rfcom.ca)
Systemic1
  • The syndrome may occur at any time during systemic therapy with mitomycin as a single agent or in combination with other cytotoxic drugs, however, most cases occur at doses ≥60 mg of mitomycin. (druglib.com)
Capecitabine3
  • Preoperative radiotherapy with capecitabine and mitomycin C in locally advanced rectal carcinoma. (druglib.com)
  • PURPOSE: To evaluate the efficacy and safety of preoperative radiotherapy with capecitabine and mitomycin C in patients with locally advanced rectal cancer. (druglib.com)
  • CONCLUSION: Preoperative chemoradiation with capecitabine and mitomycin C appeared to be effective with low toxicity in patients with locally advanced rectal cancer. (druglib.com)
Vial1
  • Each vial contains either mitomycin 5 mg and mannitol 10 mg, or mitomycin 20 mg and mannitol 40 mg, or mitomycin 40 mg and mannitol 80 mg. (druglib.com)
Topical application2
  • Inhibition of epidural fibrosis after microendoscopic discectomy with topical application of mitomycin C: a randomized, controlled, double-blind trial. (druglib.com)
  • Mitomycin C topical application is the use of the medication Mitomycin C to prevent post-procedural scarring in the larynx or trachea . (laryngopedia.com)
Cell Proliferation2
  • To serve as feeder cells, MEF must be treated with mitomycin C or by irradiation to prevent cell proliferation. (sciencellonline.com)
  • however, MEF-mt are not recommended for expanding as mitomycin C treatment prevents further cell proliferation. (sciencellonline.com)
Pterygium1
  • Evaluation of Conjunctival Autografting Augmented with Mitomycin C Application versus Ologen Implantation in the Surgical Treatment of Recurrent Pterygium. (bvsalud.org)
Micronuclei1
  • Induction of micronuclei in bone marrow by triethylenemelamine (51183) (TEM), mitomycin-C (50077) (MMC), dimethylbenzanthracene (57976) (DMBA), and vincristine (57227) was studied in rats. (cdc.gov)
Efficacy2
  • The purpose of this study is to evaluate the therapeutic efficacy of interferon alfa 2b and topical mitomycin C in patients with diagnosis of conjunctival-corneal intraepithelial neoplasia. (druglib.com)
  • Our study was aimed to evaluate the efficacy and safety of adjunctive application of mitomycin C after endoscopic-assisted probing for the treatment of congenital nasolacrimal duct obstruction in children. (unesp.br)
Precautions1
Versus1
  • We compared children who underwent endoscopic-assisted probing with mitomycin C (mitomycin C group) versus others who underwent endoscopic-assisted probing without mitomycin C (endoscopic-assisted probing group). (unesp.br)
Injections2
  • He said he has used mitomycin C injections in his glaucoma surgeries for more than a year. (medscape.com)
  • Cite this: Mitomycin C Injections Reduce Eye Pressure After Surgery - Medscape - Mar 27, 2013. (medscape.com)
Sponge1
  • A common way to apply Mitomycin C would be to take the drug in dilute form (e.g., 0.3mg per ml), saturate a cottonoid sponge with it, and then "paint" it on the area where one wants to inhibit a scarring response, holding the sponge in position for about three minutes. (laryngopedia.com)
Glaucoma2
  • History, presence, and future of mitomycin C in glaucoma fil. (lww.com)
  • In this study, mitomycin-C (MMC) al a concentration of 0.2 mg/mL was applied intraoperatively for 1 minute in 11 consecutive primary trabeculectomies to increase the success of glaucoma-filtration surgery while minimizing the incidence of postoperative complications resulting from MMC use. (medeniyet.edu.tr)
Treatment7
  • Mitomycin is used in combination with other medications to treat cancer of the stomach or pancreas that has spread to other parts of the body and has not improved or worsened after treatment with other medications, surgery, or radiation therapy. (medlineplus.gov)
  • You should not breast-feed during your treatment with mitomycin. (medlineplus.gov)
  • However, the outcomes of endoscopic-assisted probing for the treatment of congenital nasolacrimal duct obstruction with adjunctive mitomycin C in children remain unknown. (unesp.br)
  • In addition, we added mitomycin C (MMC) to the post surgery rabbit cornea in order to investigate the effect of MMC treatment on the postoperative regeneration. (elsevier.com)
  • Since then I've had treatment with Mitomycin C and several recurrences. (bladdergraffiti.com)
  • The results indicate that the steroidogenic capacity of ovaries is reduced following Mitomycin C treatment possibly due to its direct effect on ovarian DNA content. (caluniv.ac.in)
  • Curcumin reduced the side effects of mitomycin C in the treatment of breast cancer. (greenmedinfo.com)
Ophthalmic1
  • Purpose: Mitomycin C has been used in ophthalmic surgery to mitigate postoperative scarring. (unesp.br)
Radiotherapy4
  • Mitomycin is not recommended to replace appropriate surgery and/or radiotherapy. (druglib.com)
  • Anal carcinoma therapy: Can we improve on 5-fluorouracil/mitomycin/ radiotherapy? (elsevier.com)
  • Over the past several years, phase III studies have shown that combination mitomycin C (MMC) and 5-fluorouracil (5-FU) concurrent with radiotherapy had better outcomes than radiotherapy alone or 5-FU with radiotherapy. (elsevier.com)
  • Dive into the research topics of 'Anal carcinoma therapy: Can we improve on 5-fluorouracil/mitomycin/ radiotherapy? (elsevier.com)
Fibrosis2
  • The use of mitomycin C to reduce fibrosis in strabismus surgery has been reported, but the use of amniotic membrane has not. (semanticscholar.org)
  • We describe a technique which uses both mitomycin C and amniotic membrane patches to reduce fibrosis. (semanticscholar.org)
Synthesis3
  • Mitomycin C (MMC) is an alkylating agent with extraordinary ability to crosslink DNA, preventing DNA synthesis. (lww.com)
  • At high concentrations of mitomycin, cellular RNA and protein synthesis are also suppressed. (medscape.com)
  • Mitomycin selectively inhibits DNA synthesis. (medscape.com)
Combination1
  • Mitomycin C in combination with doxycycline and cefuroxime caused no regrowth at 7 days but visible spirochetal regrowth occurred after 21 day subculture. (canlyme.com)
Drug4
  • Our findings demonstrate daunomycin and daptomycin were more active than mitomycin C in single drug comparison at 10 and 20 μM, as well as in drug combinations with doxycycline and cefuroxime. (canlyme.com)
  • Mitomycin is an alkylating drug isolated from the broth of Streptomyces caespitosus . (medscape.com)
  • Mitomycin C's mechanism of action is reported to be absorption of the drug by fibroblasts, which are then "decommissioned" from producing collagen, the major component of scar tissue. (laryngopedia.com)
  • Mitomycin C. an antitumor drug. (caluniv.ac.in)
Evaluation1
  • Evaluation the Safety of a New Intraocular Mitomycin C Application Technique in the Rabbit. (dergisi.org)
Qualified physician1
  • Mitomycin should be administered under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents. (druglib.com)
Safely1
Severe3
  • Mitomycin can cause a severe decrease in the number of blood cells in your bone marrow. (medlineplus.gov)
  • Bone marrow suppression, notably thrombocytopenia and leukopenia, which may contribute to overwhelming infections in an already compromised patient, is the most common and severe of the toxic effects of mitomycin (see WARNINGS and ADVERSE REACTIONS sections). (druglib.com)
  • A condition which is characterised by severe intrauterine growth retardation with an increase in the sensitivity to mitomycin C sensitivity. (chemwatch.net)
Powder1
  • Mitomycin comes as a powder to be mixed with liquid and injected intravenously (into a vein) by a doctor or nurse in a medical facility. (medlineplus.gov)
Pharmacies1
  • Compare mitomycin prices available at Canadian and international online pharmacies with local U.S. pharmacy coupon prices. (pharmacychecker.com)
Technique1
  • Dans notre étude, nous avons évalué la surexpression de l'HER2 par technique immunohistochimique sur 30 cas, en utilisant les mêmes critères d'interprétation que pour le cancer du sein. (bvsalud.org)
Purpose1
  • PURPOSE: To assess the effect of mitomycin-C (MMC) on the tear film, corneal biomechanics, and surface irregularity in surface ablation (photorefractive keratectomy [PRK]) for low to moderate myopia. (druglib.com)
Effects4
  • Mitomycin may cause side effects. (medlineplus.gov)
  • Effects of mitomycin-C on tear film, corneal biomechanics, and surface irregularity in mild to moderate myopic surface ablation: preliminary results. (druglib.com)
  • What side effects can Mitomycin cause? (singhealth.com.sg)
  • No studies however, have investigated the potential modulatory role of resveratrol (RV) on mitomycin C (MMC)-mediated effects on colorectal cancer. (iiarjournals.org)
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