Drug Delivery Systems
Microscopy, Electron, Scanning
Technetium Tc 99m Aggregated Albumin
Serum Albumin, Bovine
Spectroscopy, Fourier Transform Infrared
5'-Nucleotidase activity of mouse peritoneal macrophages. II. Cellular distribution and effects of endocytosis. (1/3739)The diazonium salt of sulfanilic acid (DASA) can inactivate about 80% of the total 5'-nucleotidase of viable macrophages. The remaining 20% can be inactivated if the cells are first lysed in detergent, and presumably represents an intracellular pool of 5'-nucleotidase. The bulk of this pool may represent cytoplasmic vesicles derived from plasma membrane by endocytosis. This internal compartment is expanded up to threefold immediately after the cells have ingested a large latex load. This is consistent with previous observations on the internalization of 5'-nucleotidase in latex phagosomes. In latex-filled cells this intracellular pool of enzyme is inactivated over a few hours, and the cells then slowly increase their enzyme activity to nearly normal levels. However, 24 h after latex ingestion the metabolism of 5'-nucleotidase in these recovered cells is abnormal, as the rate of enzyme degradation is about twice the normal rate, and the DASA-insensitive enzyme pool in these cells is strikingly diminished. This may reflect effects of the accumulated indigestible particles on the fate of incoming pinocytic vesicles or on newly synthesized plasma membrane precursor. Another endocytic stimulus, concanavalin A, also reduces the total cell 5'-nucleotidase activity. This effect, which is time and temperature dependent, can be prevented by the competitive sugar alpha-methyl mannose. The concanavalin A inhibition can be reversed in the absence of new protein synthesis or in cells cultivated in serum-free conditions. It is not known whether the effect of concanavalin A on 5'-nucleotidase depends upon the interiorizaiton of plasma membrane or is strictly associated with events at the cell surface. (+info)
In vitro and in vivo activities of NS-718, a new lipid nanosphere incorporating amphotericin B, against Aspergillus fumigatus. (2/3739)We evaluated the in vitro and in vivo potencies of a new lipid nanosphere that incorporates amphotericin B (AmB), NS-718, against Aspergillus fumigatus. The in vitro activity of NS-718 (the MIC at which 90% of strains are inhibited [MIC90], 0.25 microgram/ml) against 18 isolates of A. fumigatus was similar to that of deoxycholate AmB (D-AmB; Fungizone; MIC90, 0.25 microgram/ml), but NS-718 was more potent than liposomal AmB (L-AmB; AmBi-some; MIC90, 1.0 microgram/ml). The in vivo efficacy of NS-718 in a rat model of invasive pulmonary aspergillosis was compared with those of D-AmB and L-AmB. A low dose (1 mg/kg of body weight) of L-AmB was ineffective (survival rate, 0%), although equivalent doses of D-AmB and NS-718 were more effective (survival rate, 17%). However, a higher dose of NS-718 (3 mg/kg) was more effective (survival rate, 100%) than equivalent doses of D-AmB and L-AmB (survival rate, 0%). To explain these differences, pharmacokinetic studies showed higher concentrations of AmB in the plasma of rats treated with NS-718 than in the plasma of those treated with D-AmB. Our results suggest that NS-718, a new preparation of AmB, is a promising antifungal agent with activity against pulmonary aspergillosis. (+info)
Quantitative study of polymer conformation and dynamics by single-particle tracking. (3/3739)We present a new method for analyzing the dynamics of conformational fluctuations of individual flexible polymer molecules. In single-particle tracking (SPT), one end of the polymer molecule is tethered to an immobile substratum. A microsphere attached to the other end serves as an optical marker. The conformational fluctuations of the polymer molecule can be measured by optical microscopy via the motion of the microsphere. The bead-and-spring theory for polymer dynamics is further developed to account for the microsphere, and together the measurement and the theory yield quantitative information about molecular conformations and dynamics under nonperturbing conditions. Applying the method to measurements carried out on DNA molecules provides information complementary to recent studies of single DNA molecules under extensional force. Combining high precision measurements with the theoretical analysis presented here creates a powerful tool for studying conformational dynamics of biological and synthetic macromolecules at the single-molecule level. (+info)
Adhesion energy of receptor-mediated interaction measured by elastic deformation. (4/3739)We investigated the role of receptor binding affinity in surface adhesion. A sensitive technique was developed to measure the surface energy of receptor-mediated adhesion. The experimental system involved a functionalized elastic agarose bead resting on a functionalized glass coverslip. Attractive intersurface forces pulled the two surfaces together, deforming the bead to produce an enlarged contact area. The Johnson-Kendall-Roberts (JKR) model was used to relate the surface energy of the interaction to the elasticity of the bead and the area of contact. The surface energies for different combinations of modified surfaces in solution were obtained from reflection interference contrast microscopy (RICM) measurements of the contact area formed by the bead and the coverslip. Studies with surfaces functionalized with ligand-receptor pairs showed that the relationship between surface energy and the association constant of the ligand binding has two regimes. At low binding affinity, surface energy increased linearly with the association constant, while surface energy increased logarithmically with the association constant in the high affinity regime. (+info)
A region of the Yersinia pseudotuberculosis invasin protein enhances integrin-mediated uptake into mammalian cells and promotes self-association. (5/3739)Invasin allows efficient entry into mammalian cells by Yersinia pseudotuberculosis. It has been shown that the C-terminal 192 amino acids of invasin are essential for binding of beta1 integrin receptors and subsequent uptake. By analyzing the internalization of latex beads coated with invasin derivatives, an additional domain of invasin was shown to be required for efficient bacterial internalization. A monomeric derivative encompassing the C-terminal 197 amino acids was inefficient at promoting entry of latex beads, whereas dimerization of this derivative by antibody significantly increased uptake. By using the DNA-binding domain of lambda repressor as a reporter for invasin self-interaction, we have demonstrated that a region of the invasin protein located N-terminal to the cell adhesion domain of invasin is able to self-associate. Chemical cross-linking studies of purified and surface-exposed invasin proteins, and the dominant-interfering effect of a non-functional invasin derivative are consistent with the presence of a self-association domain that is located within the region of invasin that enhances bacterial uptake. We conclude that interaction of homomultimeric invasin with multiple integrins establishes tight adherence and receptor clustering, thus providing a signal for internalization. (+info)
Effect of acute normovolemic hemodilution on distribution of blood flow and tissue oxygenation in dog skeletal muscle. (6/3739)Acute normovolemic hemodilution (ANH) is efficient in reducing allogenic blood transfusion needs during elective surgery. Tissue oxygenation is maintained by increased cardiac output and oxygen extraction and, presumably, a more homogeneous tissue perfusion. The aim of this study was to investigate blood flow distribution and oxygenation of skeletal muscle. ANH from hematocrit of 36 +/- 3 to 20 +/- 1% was performed in 22 splenectomized, anesthetized beagles (17 analyzed) ventilated with room air. Normovolemia was confirmed by measurement of blood volume. Distribution of perfusion within skeletal muscle was determined by using radioactive microspheres. Tissue oxygen partial pressure was assessed with a polarographic platinum surface electrode. Cardiac index (3.69 +/- 0.79 vs. 4.79 +/- 0.73 l. min-1. m-2) and muscle perfusion (4.07 +/- 0.44 vs. 5.18 +/- 0.36 ml. 100 g-1. min-1) were increased at hematocrit of 20%. Oxygen delivery to skeletal muscle was reduced to 74% of baseline values (0.64 +/- 0.06 vs. 0.48 +/- 0.03 ml O2. 100 g-1. min-1). Nevertheless, tissue PO2 was preserved (27.4 +/- 1.3 vs. 29.9 +/- 1. 4 Torr). Heterogeneity of muscle perfusion (relative dispersion) was reduced after ANH (20.0 +/- 2.2 vs. 13.9 +/- 1.5%). We conclude that a more homogeneous distribution of perfusion is one mechanism for the preservation of tissue oxygenation after moderate ANH, despite reduced oxygen delivery. (+info)
Estimation of rat muscle blood flow by microdialysis probes perfused with ethanol, [14C]ethanol, and 3H2O. (7/3739)We used the perfused rat hindquarter to evaluate whether the microdialysis ethanol technique can be used to qualitatively estimate nutritive skeletal muscle blood flow. Four microdialysis probes were inserted in different hindlimb muscles in each of 16 rats. Hindquarters were perfused at blood flow rates ranging from 0 to 21 ml. 100 g-1. min-1. The microdialysis probes were perfused at 2 microliter/min with perfusate containing ethanol, [14C]ethanol, and 3H2O. Within and between experiments outflow-to-inflow ratios (o/i) generally varied inversely with blood flow. When a low flow or no flow was maintained in hindquarters, o/i ratios first increased with time (for at least 60 min) and then leveled off. The long time constant impaired detection of rapid oscillations in blood flow, especially at low blood flow rates. Contractions per se apparently decreased o/i ratios independent of blood flow. Ethanol and [14C]ethanol o/i ratios did not differ. 3H2O o/i paralleled ethanol and [14C]ethanol o/i ratios but it was significantly lower. In conclusion, differences in skeletal muscle blood flow can be detected by the microdialysis technique. However, the slow changes in o/i, in particular at low blood flow rates, limit the usefulness of the technique for measuring dynamic changes in blood flow; caution must also be exerted during muscle contractions. 3H2O and [14C]ethanol are good alternatives to ethanol in the determination of blood flow by microdialysis. (+info)
DNA hybridization on microparticles: determining capture-probe density and equilibrium dissociation constants. (8/3739)Many DNA-probe assays utilize oligonucleotide-coated microparticles for capture of complementary nucleic acids from solution. During development of these assays, as well as in other particle-based nucleic acid applications, it is useful to know both the amount of duplex formation expected under various experimental conditions and the coating density of the capture oligonucleotide on the particle surface. We examined the simplest form of a DNA-probe microparticle assay: hybridization of a particle-bound capture oligonucleotide to its solution-phase complement. Fluorescein-labeled solution-phase oligonucleotide was hybridized to varying amounts of particles, and the amount of labeled oligonucleotide remaining in solution at equilibrium was measured. We present a simple two-state, all-or-none model for bimolecular hybridization of non-self-complementary sequences that can be used to calculate the equilibrium dissociation constant ( Kd ) from hybridization data. With experimental conditions where both the Kd value and the concentration of capture probe in the reaction are small relative to the concentration of labeled complementary oligonucleotide in the reaction, density of the capture probe on the particle's surface can also be determined. Kd values for particle-based hybridization were different from those obtained from solution-phase thermodynamic parameters. At higher temperatures, hybridization on particles was more efficient than hybridization in solution. (+info)
Polyglycolic acid (PGA) is a synthetic polymer that is commonly used in medical applications as a biodegradable scaffold for tissue engineering and regenerative medicine. It is a linear copolymer of glycolic acid, which is a naturally occurring monomer that is derived from renewable resources such as corn starch. PGA is typically produced through a chemical reaction that involves the polymerization of glycolic acid monomers in the presence of a catalyst. The resulting polymer has a high molecular weight and is hydrophilic, meaning that it is able to absorb and retain water. In the medical field, PGA is used in a variety of applications, including as a scaffold for tissue engineering, as a wound dressing, and as a carrier for drugs and other therapeutic agents. It is also used in medical devices such as sutures, staples, and absorbable pins. One of the key advantages of PGA is its ability to degrade over time, which allows it to be absorbed by the body and replaced by new tissue. This makes it an attractive material for use in tissue engineering and regenerative medicine, where the goal is to create new tissue that can replace damaged or diseased tissue.
Lactic acid is a naturally occurring organic acid that is produced by the metabolism of glucose in the body. It is a byproduct of the process of glycolysis, which occurs in the cytoplasm of cells when there is not enough oxygen available for complete oxidation of glucose to carbon dioxide and water. In the medical field, lactic acid is often measured in the blood as an indicator of tissue oxygenation and energy metabolism. High levels of lactic acid in the blood can be a sign of tissue hypoxia, which is a lack of oxygen supply to the body's tissues. This can occur in a variety of medical conditions, including sepsis, shock, and certain types of cancer. Lactic acidosis is a condition characterized by high levels of lactic acid in the blood and can be caused by a variety of factors, including liver disease, kidney failure, and certain medications. It can be a serious medical condition and requires prompt treatment. In addition to its role in metabolism and energy production, lactic acid has also been used in various medical treatments, including as a topical antiseptic and as a component of certain medications.
In the medical field, polymers are large molecules made up of repeating units or monomers. Polymers are used in a variety of medical applications, including drug delivery systems, tissue engineering, and medical devices. One common use of polymers in medicine is in drug delivery systems. Polymers can be used to encapsulate drugs and release them slowly over time, allowing for more controlled and sustained release of the drug. This can help to improve the effectiveness of the drug and reduce side effects. Polymers are also used in tissue engineering, where they are used to create scaffolds for growing new tissue. These scaffolds can be designed to mimic the structure and properties of natural tissue, allowing cells to grow and differentiate into the desired tissue type. In addition, polymers are used in a variety of medical devices, including implants, prosthetics, and surgical sutures. For example, polymers can be used to create biodegradable implants that are absorbed by the body over time, reducing the need for additional surgeries to remove the implant. Overall, polymers play an important role in the medical field, providing a range of useful materials for drug delivery, tissue engineering, and medical device applications.
Chitosan is a natural polysaccharide derived from chitin, which is a polymer of N-acetylglucosamine found in the exoskeletons of crustaceans such as shrimp and crab. Chitosan has been used in various medical applications due to its unique properties, including its ability to absorb and retain water, its biocompatibility, and its ability to modulate immune responses. In the medical field, chitosan is used in a variety of ways, including as a wound dressing, a drug delivery system, and a biofilm inhibitor. As a wound dressing, chitosan can help to promote healing by providing a moist environment that promotes cell growth and reduces inflammation. As a drug delivery system, chitosan can be used to encapsulate drugs and release them slowly over time, improving their effectiveness and reducing side effects. As a biofilm inhibitor, chitosan can help to prevent the formation of bacterial biofilms, which can be difficult to treat and can lead to chronic infections. Chitosan has also been studied for its potential use in cancer therapy, as it has been shown to have anti-tumor properties and can help to enhance the effectiveness of chemotherapy drugs. Additionally, chitosan has been used in the development of medical devices, such as catheters and implants, due to its ability to reduce inflammation and promote tissue integration.
Holmium is a chemical element with the symbol Ho and atomic number 67. It is a rare earth metal that is used in various medical applications due to its unique physical and chemical properties. In the medical field, Holmium is commonly used in the treatment of benign prostatic hyperplasia (BPH), a condition in which the prostate gland becomes enlarged, causing difficulty urinating. Holmium laser enucleation of the prostate (HoLEP) is a minimally invasive surgical procedure that uses a laser to remove the excess prostate tissue, improving urine flow and reducing symptoms. Holmium is also used in the treatment of kidney stones, particularly those that are hard and difficult to remove. Holmium laser lithotripsy is a procedure in which a laser is used to break up the kidney stones into smaller pieces that can be easily passed through the urinary tract. In addition, Holmium is used in the development of medical imaging agents, such as contrast agents for magnetic resonance imaging (MRI), and in the production of medical devices, such as surgical instruments and implants.
Gelatin is a protein derived from collagen, which is found in the connective tissues of animals such as cows, pigs, and fish. In the medical field, gelatin is commonly used as a thickening agent in various medical products, such as medications, vaccines, and medical devices. Gelatin is often used in the production of capsules, as it can be dissolved in water to create a gel-like substance that can be used to coat the capsule shell. It is also used in the production of injectable medications, as it can help to stabilize the medication and prevent it from breaking down in the body too quickly. In addition to its use in medical products, gelatin is also used in the production of various food products, such as gels, jellies, and desserts. However, in the medical field, it is typically used in a sterile, purified form to ensure that it is free from any contaminants that could potentially harm the patient.
Hexuronic acids are a type of carbohydrate that are found in the cell walls of plants and some bacteria. They are also known as hexoses or hexoses acids. Hexuronic acids are composed of six carbon atoms and are classified as aldohexoses. They are important components of the plant cell wall and play a role in the structure and function of the cell wall. Hexuronic acids are also used in the production of certain types of food and beverages, such as jams, jellies, and fruit juices. In the medical field, hexuronic acids are not commonly used for treatment or diagnosis of diseases.
Glucuronic acid is a naturally occurring organic acid that is produced by the liver as a byproduct of the metabolism of carbohydrates. It is a key component of the glycoprotein molecule hyaluronic acid, which is found in the extracellular matrix of connective tissue throughout the body. In the medical field, glucuronic acid is often used as a precursor in the synthesis of other important molecules, such as bile acids and some hormones. It is also used in the treatment of certain medical conditions, such as hyperuricemia (high levels of uric acid in the blood), where it is used to convert excess uric acid into a more water-soluble form that can be excreted from the body. In addition, glucuronic acid is used in the production of certain drugs and dietary supplements, and it has been shown to have potential anti-inflammatory and anti-cancer effects in laboratory studies. However, more research is needed to fully understand the therapeutic potential of glucuronic acid in the treatment of human diseases.
Polyvinyl Alcohol (PVA) is a synthetic polymer that is commonly used in the medical field as a water-soluble adhesive in medical tapes, dressings, and other medical devices. It is a hydrophilic polymer, meaning it is attracted to water, and is known for its biocompatibility and non-toxicity. PVA is also used as a thickening agent in various medical products, such as eye drops, nasal sprays, and oral solutions. It can help to stabilize the formulation and improve its viscosity, making it easier to apply or use. In addition, PVA has been investigated for its potential use in drug delivery systems, as it can act as a carrier for drugs and help to control their release over time. It has also been used in tissue engineering applications, as it can be used to create hydrogels that mimic the properties of natural tissue. Overall, PVA is a versatile polymer with a wide range of applications in the medical field, thanks to its unique properties and biocompatibility.
Polystyrenes are a class of synthetic polymers that are commonly used in the medical field due to their unique properties, such as their lightweight, durability, and ability to be molded into a variety of shapes and sizes. In the medical field, polystyrenes are used in a variety of applications, including as components of medical devices, such as syringes, catheters, and test tubes, as well as in packaging materials for medical equipment and supplies. Polystyrene is also used in the production of medical implants, such as hip and knee replacements, and as a component of dental prosthetics. Polystyrenes are also used in the production of medical laboratory equipment, such as centrifuges and microtiter plates, and in the manufacturing of medical instruments, such as scalpels and forceps. Additionally, polystyrene is used in the production of medical packaging materials, such as trays and bags, to protect medical equipment and supplies during transportation and storage.
Yttrium radioisotopes are radioactive isotopes of the element yttrium that are used in medical imaging and cancer treatment. Yttrium-90 (90Y) is a commonly used radioisotope in these applications. It is produced by bombarding a target with neutrons, and it emits beta particles that can be detected by imaging equipment. In medical imaging, 90Y is often used in conjunction with a radiopharmaceutical, which is a compound that contains 90Y and is designed to target specific cells or tissues in the body. For example, 90Y-labeled antibodies can be used to image and diagnose certain types of cancer, such as non-Hodgkin's lymphoma and multiple myeloma. The beta particles emitted by 90Y can also be used to destroy cancer cells through a process called radioimmunotherapy. In cancer treatment, 90Y is often used in conjunction with a radiopharmaceutical to deliver targeted radiation therapy to cancer cells. This can be particularly useful in cases where the cancer has spread to multiple sites in the body and is difficult to treat with traditional chemotherapy or radiation therapy. The radiopharmaceutical is designed to target the cancer cells specifically, minimizing damage to healthy cells and tissues.
Alginates are a type of polysaccharide that are extracted from brown seaweed. They are commonly used in the medical field as a dressing for wounds, as well as in the production of various medical devices and implants. Alginates have properties that make them useful for wound healing, including their ability to absorb and retain moisture, promote cell growth, and prevent bacterial infection. They are also biocompatible, meaning they are well-tolerated by the body and do not cause an immune response. In addition to their use in wound care, alginate-based materials are also used in the production of dental impressions, drug delivery systems, and other medical applications.
Scandium is a chemical element with the symbol Sc and atomic number 21. It is a silvery-white, lustrous transition metal that is highly reactive and is never found in nature in its pure form. In the medical field, scandium is not commonly used for therapeutic purposes. However, it has been studied for its potential use in the treatment of certain types of cancer. Scandium has been shown to have anti-cancer properties and has been used in preclinical studies to treat various types of cancer, including breast cancer, prostate cancer, and lung cancer. Scandium has also been studied for its potential use in the treatment of osteoporosis, a condition characterized by weak and brittle bones. Scandium has been shown to increase bone density and reduce the risk of fractures in animal studies. In addition, scandium has been used in the development of medical imaging agents, such as those used in magnetic resonance imaging (MRI) scans. Scandium-based MRI contrast agents have been shown to improve the contrast between healthy and diseased tissue, allowing for more accurate diagnosis and treatment of various medical conditions.
Polymethacrylic acids are a type of polymer that are commonly used in the medical field for a variety of applications. They are typically synthesized from methacrylic acid, which is a monomer that can be polymerized to form a long chain of repeating units. Polymethacrylic acids are known for their ability to form gels and hydrogels, which are materials that can absorb and retain large amounts of water. In the medical field, polymethacrylic acids are often used as drug delivery systems. They can be used to encapsulate drugs and release them slowly over time, which can help to improve the effectiveness and duration of treatment. They can also be used as wound dressings, as they can absorb and retain fluids and help to protect the wound from infection. Additionally, polymethacrylic acids have been used in tissue engineering applications, as they can be used to create scaffolds that can support the growth and development of new tissue.
Cerium radioisotopes are radioactive isotopes of the element cerium that are used in various medical applications. These isotopes are typically produced by bombarding cerium targets with high-energy particles, such as protons or neutrons, in a nuclear reactor or particle accelerator. Cerium radioisotopes have a variety of uses in medicine, including: 1. Diagnostic imaging: Some cerium radioisotopes, such as cerium-144, are used as tracers in diagnostic imaging studies. These isotopes can be attached to molecules that are specific to certain organs or tissues in the body, allowing doctors to visualize the distribution of the tracer and diagnose various medical conditions. 2. Radiation therapy: Cerium radioisotopes can also be used in radiation therapy to treat cancer. For example, cerium-144 has been used in the treatment of bone metastases, a condition in which cancer has spread to the bones. 3. Nuclear medicine: Cerium radioisotopes can be used in nuclear medicine to treat a variety of conditions, including hyperthyroidism, thyroid cancer, and certain types of bone disease. These isotopes can be administered to the body in the form of a radioactive pill or injection, and they work by emitting radiation that destroys cancer cells or slows down the overactivity of certain organs. Overall, cerium radioisotopes play an important role in medical imaging and treatment, and they are widely used in hospitals and clinics around the world.
Technetium Tc 99m Aggregated Albumin is a radiopharmaceutical used in medical imaging to diagnose and monitor liver and spleen diseases. It is a complex of technetium-99m (Tc-99m), a radioactive isotope, and aggregated albumin, a protein found in the blood. The Tc-99m is attached to the albumin, which allows it to be transported to the liver and spleen, where it is taken up by the cells. The radiopharmaceutical is then imaged using a gamma camera to visualize the uptake of the Tc-99m in the liver and spleen, which can help diagnose conditions such as liver and spleen tumors, infections, and cirrhosis.
In the medical field, an emulsion is a mixture of two immiscible liquids, such as oil and water, that are dispersed in the form of small droplets. These droplets are typically stabilized by an emulsifying agent, which prevents the two liquids from separating and allows them to remain in a stable mixture. Emulsions are commonly used in the medical field for a variety of purposes, including drug delivery, imaging, and therapy. For example, oil-in-water emulsions are often used to deliver drugs or other therapeutic agents to specific areas of the body, such as the lungs or the eye. They can also be used in imaging studies to help visualize certain structures or tissues within the body. Emulsions can be prepared in a variety of ways, including mechanical agitation, high-pressure homogenization, and ultrasonication. The choice of preparation method depends on the specific properties of the emulsifying agent and the liquids being mixed, as well as the desired properties of the final emulsion.
Radioisotopes are isotopes of an element that emit radiation, such as alpha particles, beta particles, or gamma rays. In the medical field, radioisotopes are used in a variety of diagnostic and therapeutic applications. In diagnostic imaging, radioisotopes are used to create images of the body's internal structures. For example, a radioisotope such as technetium-99m can be injected into the bloodstream and then detected by a gamma camera to create an image of the heart, lungs, or other organs. This type of imaging is commonly used to diagnose conditions such as cancer, heart disease, and bone disorders. Radioisotopes are also used in therapeutic applications, such as radiation therapy for cancer. In this treatment, a radioisotope is introduced into the body, usually by injection or inhalation, and then targeted to a specific area of the body where it emits radiation that destroys cancer cells. Radioisotopes are also used in targeted radionuclide therapy, where a radioisotope is attached to a molecule that specifically targets cancer cells, allowing for more precise delivery of radiation. Overall, radioisotopes play a critical role in medical imaging and therapy, allowing for the diagnosis and treatment of a wide range of conditions.
Polyglactin 910, also known as Vicryl, is a synthetic absorbable surgical suture made from copolymerized glycolide and lactide. It is commonly used in various surgical procedures due to its strength, flexibility, and ability to be absorbed by the body over time. The "910" in the name refers to the molecular weight of the polymer, which is approximately 910 daltons. Polyglactin 910 is available in various sizes and shapes, including monofilament, multifilament, and braided sutures. It is also available in both plain and chromic forms, with chromic sutures containing chromium to enhance their tensile strength and knot security.
Strontium radioisotopes are radioactive isotopes of the element strontium that are used in medical applications. These isotopes emit radiation that can be detected and measured, and they are used in a variety of medical procedures, including: 1. Bone scanning: Strontium-89 and strontium-90 are used in bone scanning to detect bone metastases (cancer that has spread to the bones) and to monitor the effectiveness of treatment. 2. Cardiac imaging: Strontium-82 is used in cardiac imaging to assess blood flow to the heart and to diagnose and monitor heart disease. 3. Cancer treatment: Strontium-89 and strontium-90 are also used in cancer treatment, particularly for bone metastases, by delivering targeted radiation to the affected area. Strontium radioisotopes are typically produced in nuclear reactors and are then purified and formulated for medical use. They are administered to patients through intravenous injection or inhalation, and the radiation they emit is detected using specialized imaging equipment.
Iridoid glycosides are a group of natural compounds found in many plants, particularly in the families Lamiaceae, Scrophulariaceae, and Rubiaceae. They are characterized by the presence of an iridoid nucleus, which is a six-membered ring structure containing a carbonyl group and a hydroxyl group. Iridoid glycosides have a variety of biological activities, including anti-inflammatory, anti-bacterial, anti-viral, and anti-cancer properties. They are also known to have antioxidant and free radical scavenging activity. In the medical field, iridoid glycosides are used as active ingredients in traditional herbal remedies and as components of modern pharmaceuticals. They have been studied for their potential use in the treatment of a range of conditions, including respiratory infections, gastrointestinal disorders, and cancer. Some examples of iridoid glycosides that are used in medicine include aucubin, catalpol, geniposide, and glycyrrhizin.
In the medical field, "polyesters" typically refers to a class of synthetic polymers that are derived from petrochemicals or renewable resources such as vegetable oils. They are commonly used in medical applications due to their biocompatibility, durability, and versatility. One example of a polyester used in medicine is polyethylene terephthalate (PET), which is commonly used to make medical devices such as catheters, surgical sutures, and packaging for medical equipment. PET is a strong, lightweight, and flexible material that can be easily processed into various shapes and sizes. Another example of a polyester used in medicine is polybutylene terephthalate (PBT), which is used to make medical implants such as orthopedic screws and plates. PBT is a high-strength, heat-resistant material that can withstand the rigors of the human body. Overall, polyesters are a versatile class of materials that have a wide range of applications in the medical field, from packaging and sterilization to implantable devices and surgical instruments.
Acrylic resins are a type of polymer that are commonly used in the medical field for a variety of applications. They are typically made from acrylic acid or methacrylic acid, which are then polymerized to form a solid, durable material. One common use of acrylic resins in medicine is in the production of dental prosthetics, such as dentures and dental bridges. Acrylic resins are used to create the artificial teeth and gums that are used to replace missing teeth or to improve the appearance of the smile. Acrylic resins are also used in the production of medical devices, such as catheters and surgical instruments. They are often used because of their durability, flexibility, and ability to be molded into a variety of shapes and sizes. In addition, acrylic resins are sometimes used in the treatment of certain medical conditions. For example, they may be used to create implants for the treatment of joint disorders or to reinforce weakened bones. Overall, acrylic resins are a versatile and widely used material in the medical field, with a range of applications in dentistry, medical devices, and other areas.
In the medical field, a hydrogel is a type of polymer network that is capable of absorbing and retaining a large amount of water or biological fluids. Hydrogels are often used in medical applications due to their ability to mimic the properties of natural tissues, such as their ability to swell and contract in response to changes in their environment. Hydrogels can be made from a variety of materials, including natural polymers such as gelatin, alginate, and chitosan, as well as synthetic polymers such as polyacrylamide, polyvinyl alcohol, and polyethylene glycol. They can be crosslinked to create a three-dimensional network that is stable and resistant to deformation. In medical applications, hydrogels are used for a variety of purposes, including drug delivery, tissue engineering, wound healing, and as a scaffold for cell growth. They can be designed to release drugs or other therapeutic agents over time, or to provide a supportive environment for cells to grow and differentiate. Hydrogels are also used in contact lenses, artificial skin, and other biomedical devices.
In the medical field, a suspension is a type of medication that is administered as a liquid or powder that is suspended in a liquid. Suspensions are typically used when a medication needs to be given in a form that is not available as a tablet, capsule, or other solid form. Suspensions can be made from a variety of ingredients, including active pharmaceutical ingredients (APIs), excipients, and stabilizers. APIs are the active ingredients that provide the therapeutic effect of the medication, while excipients are substances that help to improve the stability, texture, or taste of the suspension. Stabilizers are added to prevent the API from settling out of the suspension and to ensure that the suspension remains homogeneous. Suspensions are commonly used to deliver medications to children, as well as to patients who have difficulty swallowing solid forms of medication. They can also be used to deliver medications that are not available in solid form, such as certain vaccines or antiviral medications. It is important to note that suspensions can be more prone to contamination and degradation than solid forms of medication, so they must be stored and handled properly to maintain their effectiveness and safety.
In the medical field, acrylates refer to a group of chemicals that are commonly used in the production of medical devices, such as catheters, implants, and surgical instruments. Acrylates are typically used as a coating or adhesive on these devices to improve their biocompatibility, durability, and functionality. Acrylates are made up of acrylic acid monomers, which are polymerized to form long chains of molecules. These chains can be crosslinked to create a more rigid and durable material. Acrylates are known for their excellent adhesion properties, making them ideal for use in medical devices that need to adhere to tissues or other surfaces. However, acrylates can also be allergenic and may cause skin irritation or other adverse reactions in some individuals. As a result, medical device manufacturers must carefully consider the potential risks and benefits of using acrylates in their products and take steps to minimize any potential adverse effects.
Serum Albumin, Bovine is a type of albumin, which is a type of protein found in the blood plasma of mammals. It is derived from the blood of cows and is used as a source of albumin for medical purposes. Albumin is an important protein in the body that helps to maintain the osmotic pressure of blood and transport various substances, such as hormones, drugs, and fatty acids, throughout the body. It is often used as a plasma expander in patients who have lost a significant amount of blood or as a replacement for albumin in patients with liver disease or other conditions that affect albumin production.
Tin radioisotopes are radioactive isotopes of the element tin that are used in various medical applications. These isotopes are typically produced by bombarding stable tin isotopes with high-energy particles, such as protons or neutrons, in a nuclear reactor or particle accelerator. Some common tin radioisotopes used in medicine include tin-117m, tin-119m, and tin-120m. These isotopes emit low-energy gamma rays that can be detected by gamma cameras, allowing doctors to create detailed images of the body's internal structures. Tin radioisotopes are used in a variety of medical applications, including: 1. Diagnostic imaging: Tin radioisotopes are used in nuclear medicine imaging techniques, such as single-photon emission computed tomography (SPECT), to detect and diagnose various diseases and conditions, such as cancer, heart disease, and neurological disorders. 2. Radiation therapy: Tin radioisotopes are used in targeted radionuclide therapy to treat certain types of cancer. These isotopes are attached to molecules that specifically target cancer cells, delivering a high dose of radiation to the cancer cells while minimizing damage to healthy tissue. 3. Research: Tin radioisotopes are used in research to study the biology and chemistry of the element tin, as well as to investigate the mechanisms of various diseases and conditions.
Hydrogels are a type of polymer network that can absorb and retain a large amount of water or biological fluids. In the medical field, hydrogels are used in a variety of applications, including drug delivery, tissue engineering, and wound healing. One of the main advantages of hydrogels in medicine is their ability to mimic the natural extracellular matrix (ECM) of tissues, which provides a supportive environment for cells to grow and differentiate. Hydrogels can be designed to have specific mechanical properties, degradation rates, and drug release profiles, making them versatile materials for a range of medical applications. For example, hydrogels can be used as drug delivery systems to release drugs slowly over time, reducing the need for frequent dosing and minimizing side effects. They can also be used as scaffolds for tissue engineering, providing a supportive environment for cells to grow and differentiate into functional tissues. In wound healing, hydrogels can be used as dressings to provide a moist environment that promotes healing and reduces the risk of infection. They can also be loaded with growth factors or other bioactive molecules to enhance the healing process. Overall, hydrogels have a wide range of potential applications in the medical field, and ongoing research is exploring new ways to use these materials to improve patient outcomes.
Methylcellulose is a water-soluble polymer that is commonly used in the medical field as a thickening agent, emulsifier, and stabilizer. It is derived from cellulose, which is a natural polymer found in plant cell walls. Methylcellulose is often used in medical applications such as drug delivery systems, ophthalmic solutions, and wound dressings. It can help to improve the stability and bioavailability of certain drugs, and can also be used to create gels and other formulations that are easy to apply and absorb. In addition to its use in medical applications, methylcellulose is also used in a variety of other industries, including food and cosmetics. It is generally considered to be safe for use in humans, although high doses may cause digestive upset in some people.
In the medical field, "oils" typically refer to liquid substances that are derived from plants, animals, or minerals, and are used for a variety of purposes. Some common examples of medical oils include: 1. Essential oils: These are highly concentrated oils that are extracted from plants through distillation or expression. They are often used for aromatherapy, massage therapy, and other forms of alternative medicine. 2. Carrier oils: These are oils that are used to dilute essential oils or other active ingredients, making them safe for topical application. Examples include coconut oil, jojoba oil, and almond oil. 3. Medicinal oils: These are oils that are used for their therapeutic properties, such as anti-inflammatory, analgesic, or antiseptic effects. Examples include tea tree oil, lavender oil, and eucalyptus oil. 4. Dietary oils: These are oils that are used for cooking or as a source of dietary fat. Examples include olive oil, canola oil, and vegetable oil. It's important to note that the use of oils in medicine should always be done under the guidance of a qualified healthcare professional, as some oils can be toxic or cause allergic reactions if used improperly.
Pancreatin is a mixture of digestive enzymes that are produced by the pancreas. It is typically used as a medication to help with the digestion of food in people who have digestive disorders or who are unable to produce enough digestive enzymes on their own. Pancreatin contains enzymes such as amylase, lipase, and protease, which help to break down carbohydrates, fats, and proteins in food, respectively. It is available in various forms, including tablets, capsules, and liquid, and is usually taken with meals.
Staphylococcal Toxoid is a vaccine that is used to prevent the occurrence of staphylococcal infections. It is made from a weakened form of the toxin produced by the bacteria Staphylococcus aureus, which is one of the most common causes of skin infections, food poisoning, and other types of infections. The vaccine works by stimulating the body's immune system to produce antibodies against the staphylococcal toxin. These antibodies can then recognize and neutralize the toxin if the person is exposed to the bacteria in the future, preventing the development of disease. Staphylococcal Toxoid is typically given as a shot in the arm, and it is usually given in combination with other vaccines, such as the diphtheria, tetanus, and pertussis (DTaP) vaccine. It is recommended for children and adults who are at risk of staphylococcal infections, such as healthcare workers, people with weakened immune systems, and people who have had previous staphylococcal infections.
Cerium isotopes are radioactive forms of the element cerium that are used in the medical field for various diagnostic and therapeutic purposes. Cerium-144 is a synthetic radioisotope that is used in nuclear medicine for imaging bone and soft tissue. It is produced by bombarding a target with high-energy protons, and is then used in diagnostic procedures such as bone scans to detect bone metastases, fractures, and other bone abnormalities. Cerium-144 is also used in radiation therapy for the treatment of certain types of cancer, such as prostate cancer. It is administered as a radioactive implant in the prostate gland, where it emits low-energy beta particles that destroy cancer cells while minimizing damage to surrounding healthy tissue. Cerium-144 has several advantages over other radioisotopes used in nuclear medicine, including a relatively long half-life of 182 days, low toxicity, and low energy emissions that minimize radiation exposure to patients and medical staff.
In the medical field, glycolates refer to compounds that contain the functional group -COOH, which is known as a carboxyl group. Glycolates are often used as intermediates in the production of other compounds, such as pharmaceuticals and agrochemicals. One common example of a glycolate in medicine is glycolic acid, which is used in skin care products and as an ingredient in certain acne treatments. Glycolic acid is a type of alpha-hydroxy acid (AHA) that is derived from sugar cane and has been shown to exfoliate the skin, improve skin texture, and reduce the appearance of fine lines and wrinkles. Glycolates can also be used as a preservative in certain medical products, such as eye drops and injectable medications. They work by inhibiting the growth of microorganisms that can cause infections in these products. Overall, glycolates play an important role in the production of a wide range of medical products and have a variety of applications in the field of medicine.
Durapatite is a synthetic bone substitute material that is used in orthopedic and dental surgeries. It is a type of calcium phosphate ceramic that is similar in composition to natural bone and is designed to promote bone growth and regeneration. Durapatite is typically used in procedures such as bone grafting, where it is placed in the body to help fill in gaps or defects in bone tissue. It can also be used as an alternative to autografts (bone taken from the patient's own body) or allografts (bone taken from a donor) in certain cases. Durapatite has several advantages over other bone substitute materials, including its ability to promote bone growth and its biocompatibility with the body. It is also relatively easy to shape and can be customized to fit the specific needs of each patient. Overall, Durapatite is a useful tool for surgeons and dentists who are looking for a safe and effective way to promote bone growth and regeneration in the body.
Polyethylene glycols (PEGs) are a group of water-soluble polymers that are commonly used in the medical field as solvents, dispersants, and stabilizers. They are made by polymerizing ethylene oxide and have a hydroxyl (-OH) group at each end of the molecule. PEGs are used in a variety of medical applications, including as a carrier for drugs and other therapeutic agents, as a lubricant for medical devices, and as an ingredient in various medical products such as ointments, creams, and lotions. They are also used in diagnostic imaging agents, such as contrast agents for X-rays and magnetic resonance imaging (MRI). PEGs are generally considered to be safe for use in humans, although high doses or prolonged exposure may cause irritation or allergic reactions. They are also used in food and personal care products, and are generally recognized as safe for these applications as well.
Microsphere (software company)
Sidney W. Fox
Stephen Arnold (scientist)
Physics of magnetic resonance imaging
Uterine artery embolization
Chemical sensor array
Microsphere management of liver mets gains strength
Risperidone Microspheres - Health Information Library | PeaceHealth
225h) Evaluating the Role of Carbon Microspheres in an Aqueous Lubricant - the Stribeck Curve Analysis | AIChE
Quantum Dots & Microspheres | Thermo Fisher Scientific - US
Facile fabrication of golf ball-like hollow microspheres of organic-inorganic silica - Journal of Materials Chemistry (RSC...
Poly (lactide-co-glycolide) microspheres in respirable sizes enhance an In vitro T cell response to recombinant Mycobacterium...
Tailoring the Properties of Thermoplastic Starch with Bamboo Powder and/or Hollow Glass Microspheres
PSL APAC talks microsphere formulation innovation at ISPE Singapore
Fluorescent Microsphere Resource Center, University of Washington - ITHS Resource Directory
MicroRNA-31 Reduces Inflammatory Signaling and Promotes Regeneration in Colon Epithelium, and Delivery of Mimics in...
Polymeric Microspheres and Magnetic Beads
Study on UC Phase Control of UC Ceramic Microspheres Prepared by Sol-Gel Method | ICONE | ASME Digital Collection
Microspheres Uses - Microspheres Online
Polystyrene Microspheres | Applied Polytech
HOLLOW CERAMIC MICROSPHERES - Nanovision Chemicals
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Vascular Lesion Embolization Imaging: Practice Essentials, Embolization Materials And Substances, Vascular Anomalies
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"Microfluidic synthesis of PLGA/carbon quantum dot microspheres for vas" by Meisam Omidi, Mohadeseh Hashemi et al.
"Evaluation of a microsphere-based immunoassay (MIA) in measuring diagn" by Jason H. Ambrose
The Development of Alginate-Based Microspheres for Endovascular Applications
Monodisperse Hollow Microspheres, Hollow Microsheres with Silica& Polystyrene Shell
Fluorescent Microspheres, Microparticles and Spherical Powders - Properties and Applications
- Polybead® Carboxylate Microspheres are monodisperse polystyrene microspheres that contain surface carboxyl groups. (technochemical.com)
- EPRUI Biotech Co. Ltd is the top monodisperse microspheres supplier in the world who is able to supply 20nm-1000um various kinds of microbeads with precise particle size control technology. (epruibiotech.com)
- With precise particle size control technology, EPRUI supplies monodisperse microspheres with narrow particle size distribution. (epruibiotech.com)
- The annual output of monodisperse microspheres reaches hundreds of kilos. (epruibiotech.com)
- The present monodisperse and controllable VEGF loaded microspheres with reproducible manner could be widely used in tissue engineering and therapeutic applications. (marquette.edu)
- A novel application of thermally induced phase separation ( TIPS ) is described enabling the rapid formation of monodisperse porous microspheres . (bvsalud.org)
- Applied Polytech offers uniform polystyrene latex microspheres that may be used as-is for self arrangement of microspheres, filter membrane screening, fluid dynamics research, photonic crystal film formation, instrument calibration, particle size standard and chromatographic media or coated with proteins via adsorption for use in diagnostic tests and assays. (appliedpolytech.com)
- Our carboxylate-modified polystyrene latex microspheres are suitable for the covalent immobilization of proteins, peptides, nucleic acids, turbidimetric assay, flow cytometric immunoassay, and homogenous immunoassay. (appliedpolytech.com)
- Recombinant Ag85B was expressed from two Escherichia coli strains and encapsulated by spray-drying in PLGA microspheres with/without adjuvants. (rti.org)
- THP-1 macrophage-like cells exposed with PLGA-rAg85B microspheres induced the DB-1 cells to produce IL-2 at a level that was two orders of magnitude larger than the response elicited by soluble rAg85B. (rti.org)
- PLGA microspheres in respirable sizes were effective in delivering rAg85B in an immunologically relevant manner to macrophages. (rti.org)
- The biodegradable microspheres of repaglinide is prepare using poly(lactic-co-glycolic acid) (PLGA) by emulsion solvent evaporation technique. (johronline.com)
- Key words: Biodegradable, Microspheres, Poly(lactic-co-glycolic acid) (PLGA), Repaglinide, Surface Electron Microscopy (SEM) and Fourier's Transformation Infra Red Spectroscopy (FT-IR). (johronline.com)
- Microfluidic synthesis of PLGA/carbon quantum dot microspheres for vas" by Meisam Omidi, Mohadeseh Hashemi et al. (marquette.edu)
- In this study, vascular endothelial growth factor (VEGF) loaded poly(D,L-lactide- co -glycolide) (PLGA) - carbon quantum dot microspheres were produced using microfluidic platforms. (marquette.edu)
- and Tayebi, Lobat, "Microfluidic synthesis of PLGA/carbon quantum dot microspheres for vascular endothelial growth factor delivery" (2019). (marquette.edu)
- You can also choose from our widest selection of fluorescent, colored or white, surfactant-free, ultraclean microspheres and nanospheres that set the bar for highest performance, quality and precision. (thermofisher.com)
- Our fluorescent microspheres are used for a wide range of applications including blood flow, flow cytometer and microscope calibration, in vivo imaging and more. (thermofisher.com)
- Welcome to the Fluorescent Microsphere Resource Center (FMRC). (iths.org)
- The primary purpose of the FMRC is to facilitate communications and disseminate information about microsphere methods in general and fluorescent microspheres in specific. (iths.org)
- Effect of locally delivered minocycline microspheres on markers of bone resorption. (bvsalud.org)
- Powder Systems Limited (PSL) Asia-Pacific manager, Pierre Landais, will present on Thursday 25 August, during the Aseptic Process & Technology plenary session, on the hot topic of Sterile Manufacturing of Polymeric Microsphere Drug Delivery Devices. (manufacturingchemist.com)
- With over 35 years experience, Estapor® Microspheres is a leading brand of polymeric supports for in vitro diagnostics, life sciences, biotechnology, cosmetics, electronics and environment applications. (merckmillipore.com)
- Irreversible adsorption of gold nanospheres on fiber optical tapers and microspheres. (cdc.gov)
- Microspheres with particle size below 3um are supplied as a 10% solids suspension (100mg/mL) in de-ionized water (Milli-Q water) but can also choose from 10-100 mg/mL just let us know! (appliedpolytech.com)
- The evaluation of microspheres prepared are perform on the basis of various parameters like particle size, percentage yield, drug entrapment efficiency, surface morphology (SEM), drug-polymer interaction (FT-IR study), in vitro drug release kinetics and stability studies. (johronline.com)
- Moreover, the combined TIPS /oil-in- water emulsion technique allows for the production of microspheres with isotropic pore morphology with interconnected spherical pores of 30-70microm and well-formed porous microspheres of 10-200microm in diameter with an open porous surface. (bvsalud.org)
- Everything about microspheres and research utilizing precision spherical particles. (microspheres.us)
- We are compiling a digital database on everything that has to do with microspheres and creating a destination for scientists working with precision spherical particles. (microspheres.us)
- SEM reveals that microspheres are spherical and has nearly smooth surface morphology. (johronline.com)
- EDAC-mediated coupling is often used for the covalent immobilization of amine-terminated proteins, DNA, or other molecules on carboxyl-functionalized PS and PS/DVB microspheres. (appliedpolytech.com)
- In this study, bamboo powder and/or hollow glass microspheres were added to thermoplastic cassava starch in order to overcome its drawbacks. (techscience.com)
- The addition of hollow glass microspheres provides an optimal balance between hydrophobicity and mechanical strength. (techscience.com)
- Hollow ceramic spheres are hollow microspheres, containing nitrogen and carbon dioxide gas negatively pressurized inside. (nanovisionchemicals.com)
- Being part of the Aseptic Process and Technology during day one of the conference is a great opportunity to discuss with pharma and bio manufacturing professionals the current conundrum of microsphere formulation manufacturing. (manufacturingchemist.com)
- We offer the widest selection of ultraclean, surfactant-free microspheres for research and commercial applications. (thermofisher.com)
- Mineral fillers and microspheres to modify the performance of our synthetic gypsums. (veltman-italia.it)
- Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers. (bvsalud.org)
- Yelena Lipovetskaya, the CEO and co-founder of Cospheric LLC, the leading global supplier of precision microspheres, was recently interviewed on 805conversations podcast which features engaging talks with leaders and thinkers in the 805 region in California. (microspheres.us)
- In this podcast, Yelena talks about the microsphere company, the foundations, and the path forward. (microspheres.us)
- Carbon Microspheres (CMS) have great potential as additives for enhancing the performance of base lubricants. (aiche.org)
- Microspheres suitable for aerosol delivery to the lungs (3.4-4.3 mu m median diameter) and targeting alveolar macrophages were manufactured. (rti.org)
- Novel fabrication techniques to produce microspheres by thermally induced phase separation for tissue engineering and drug delivery. (bvsalud.org)
- Amine-functionalized microspheres offer further options for coupling of biomolecules. (appliedpolytech.com)
- The framework components indicated the presence of silica and polymethylsilsesquioxane, and polymethylsilsesquioxane was distributed on the surface of the microspheres. (rsc.org)
- Polystyrene divinylbenzene or PS-DVB microspheres are robust polymer material used as the base framework for most polymer HPLC packing materials. (epruibiotech.com)
- Microspheres used as drug delivery devices are revolutionary because they provide exceptional advantages from controlled and sustained release capabilities to medicine protection and longer shelf life for vaccines, cancer treatment, diabetes or hormonal disorder medication. (manufacturingchemist.com)
- MicroRNA-31 Reduces Inflammatory Signaling and Promotes Regeneration in Colon Epithelium, and Delivery of Mimics in Microspheres Reduces Colitis in Mice. (stembook.org)
- The objective of the present study is to prepare repaglinide microspheres for the sustained delivery of the drug for better patient care in the management of diabetics. (johronline.com)
- None of this research or treatment application would be possible without a multidisciplinary approach that incorporates the latest in imaging technology to localize tumors, evaluate extent of disease, assess the safety of future microsphere treatment, and confirm treatment success. (diagnosticimaging.com)
- Whether you are building hi-tech weapon effects for a blockbuster sci-fi shooter, or creating complex layered transitions for a cutting edge electronic music project, Microsphere delivers an extraordinary palette of sound that will take your productions into uncharted territory. (ableton.com)
- The blue microspheres of Jojoba waxes create a gentle smoothing and exfoliating effect. (mcdbeautylife.com)
- The microspheres are prepared with different drug-to-carrier ratios and considering other variables (i.e. solvent, surfactant and stirrer speed) as well. (johronline.com)
- The various kinetic equations indicate that the in vitro drug release is of zero order release with initial burst from repaglinide microspheres. (johronline.com)
- Carcinoid tumor in the liver treated with microspheres has demonstrated excellent response and reversal of clinical symptoms. (diagnosticimaging.com)
- This patient, who presented with right uveal cancer (A) and synchronous liver metastases (B), had a complete response within six months of microsphere treatment in the liver (C), which contained persistent cancer despite 13 prior transcatheter arterial chemoembolization procedures. (diagnosticimaging.com)
- During the advisory committee meeting, representatives from the Canton, Massachusetts, based Collegium showed that the medication could be given by breaking open the capsule and pouring the oxycodone microspheres into a feeding tube or sprinkling them onto soft food or directly into the mouth. (medscape.com)
- With more than 6000 patients treated in the U.S. alone in the past three years, a significant body of peer-reviewed literature has been published to aid in understanding how and in which patient population to use this treatment, particularly yttrium-90 microspheres. (diagnosticimaging.com)
- The patient experienced 70% reduction in his serum tumor marker value and significant reduction in carcinoid symptoms after a single microsphere treatment. (diagnosticimaging.com)
- These microspheres containing rAg85B were assessed for their ability to deliver antigen to macrophages for subsequent processing and presentation to the specific CD4 T-hybridoma cells DB-1. (rti.org)