Small encapsulated gas bubbles (diameters of micrometers) that can be used as CONTRAST MEDIA, and in other diagnostic and therapeutic applications. Upon exposure to sufficiently intense ultrasound, microbubbles will cavitate, rupture, disappear, release gas content. Such characteristics of the microbubbles can be used to enhance diagnostic tests, dissolve blood clots, and deliver drugs or genes for therapy.
A subfield of acoustics dealing in the radio frequency range higher than acoustic SOUND waves (approximately above 20 kilohertz). Ultrasonic radiation is used therapeutically (DIATHERMY and ULTRASONIC THERAPY) to generate HEAT and to selectively destroy tissues. It is also used in diagnostics, for example, ULTRASONOGRAPHY; ECHOENCEPHALOGRAPHY; and ECHOCARDIOGRAPHY, to visually display echoes received from irradiated tissues.
The application of high intensity ultrasound to liquids.
Substances used to allow enhanced visualization of tissues.
Liquid perfluorinated carbon compounds which may or may not contain a hetero atom such as nitrogen, oxygen or sulfur, but do not contain another halogen or hydrogen atom. This concept includes fluorocarbon emulsions and fluorocarbon blood substitutes.
The use of focused, high-frequency sound waves to produce local hyperthermia in certain diseased or injured parts of the body or to destroy the diseased tissue.
The visualization of deep structures of the body by recording the reflections or echoes of ultrasonic pulses directed into the tissues. Use of ultrasound for imaging or diagnostic purposes employs frequencies ranging from 1.6 to 10 megahertz.
The branch of physics that deals with sound and sound waves. In medicine it is often applied in procedures in speech and hearing studies. With regard to the environment, it refers to the characteristics of a room, auditorium, theatre, building, etc. that determines the audibility or fidelity of sounds in it. (From Random House Unabridged Dictionary, 2d ed)
Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity.
Water-soluble proteins found in egg whites, blood, lymph, and other tissues and fluids. They coagulate upon heating.
Blocking of a blood vessel by air bubbles that enter the circulatory system, usually after TRAUMA; surgical procedures, or changes in atmospheric pressure.
Any device or element which converts an input signal into an output signal of a different form. Examples include the microphone, phonographic pickup, loudspeaker, barometer, photoelectric cell, automobile horn, doorbell, and underwater sound transducer. (McGraw Hill Dictionary of Scientific and Technical Terms, 4th ed)
The use of molecularly targeted imaging probes to localize and/or monitor biochemical and cellular processes via various imaging modalities that include RADIONUCLIDE IMAGING; ULTRASONOGRAPHY; MAGNETIC RESONANCE IMAGING; FLUORESCENCE IMAGING; and MICROSCOPY.
Small uniformly-sized spherical particles, of micrometer dimensions, frequently labeled with radioisotopes or various reagents acting as tags or markers.
Sulfur hexafluoride. An inert gas used mainly as a test gas in respiratory physiology. Other uses include its injection in vitreoretinal surgery to restore the vitreous chamber and as a tracer in monitoring the dispersion and deposition of air pollutants.
High-amplitude compression waves, across which density, pressure, and particle velocity change drastically. The mechanical force from these shock waves can be used for mechanically disrupting tissues and deposits.
Tailored macromolecules harboring covalently-bound biologically active modules that target specific tissues and cells. The active modules or functional groups can include drugs, prodrugs, antibodies, and oligonucleotides, which can act synergistically and be multitargeting.
A versatile contrast medium used for DIAGNOSTIC X-RAY RADIOLOGY.
Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues. The standard approach is transthoracic.
The vapor state of matter; nonelastic fluids in which the molecules are in free movement and their mean positions far apart. Gases tend to expand indefinitely, to diffuse and mix readily with other gases, to have definite relations of volume, temperature, and pressure, and to condense or liquefy at low temperatures or under sufficient pressure. (Grant & Hackh's Chemical Dictionary, 5th ed)
A major protein in the BLOOD. It is important in maintaining the colloidal osmotic pressure and transporting large organic molecules.
The resistance that a gaseous or liquid system offers to flow when it is subjected to shear stress. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
A type of stress exerted uniformly in all directions. Its measure is the force exerted per unit area. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)

Focal hepatic lesions: contrast-enhancement patterns at pulse-inversion harmonic US using a microbubble contrast agent. (1/563)

OBJECTIVE: To analyze the contrast-enhancement patterns obtained at pulse-inversion harmonic imaging (PIHI) of focal hepatic lesions, and to thus determine tumor vascularity and the acoustic emission effect. MATERIALS AND METHODS: We reviewed pulse-inversion images in 90 consecutive patients with focal hepatic lesions, namely hepatocellular carcinoma (HCC) (n=43), metastases (n=30), and hemangioma (n=17). Vascular and delayed phase images were obtained immediately and five minutes following the injection of a microbubble contrast agent. Tumoral vascularity at vascular phase imaging and the acoustic emission effect at delayed phase imaging were each classified as one of four patterns. RESULTS: Vascular phase images depicted internal vessels in 93% of HCCs, marginal vessels in 83% of metastases, and peripheral nodular enhancement in 71% of hemangiomas. Delayed phase images showed inhomogeneous enhancement in 86% of HCCs; hypoechoic, decreased enhancement in 93% of metastases; and hypoechoic and reversed echogenicity in 65% of hemangiomas. Vascular and delayed phase enhancement patterns were associated with a specificity of 91% or greater, and 92% or greater, respectively, and with positive predictive values of 71% or greater, and 85% or greater, respectively. CONCLUSION: Contrast-enhancement patterns depicting tumoral vascularity and the acoustic emission effect at PIHI can help differentiate focal hepatic lesions.  (+info)

Leukocyte-targeted myocardial contrast echocardiography can assess the degree of acute allograft rejection in a rat cardiac transplantation model. (2/563)

BACKGROUND: Repetitive endomyocardial biopsies are necessary to monitor the effects of immunosuppressants after cardiac transplantation. Contrast ultrasound with microbubble targeting of leukocytes detects acute leukocyte infiltration. We examined whether leukocyte-targeted myocardial contrast echocardiography (MCE) could provide for the quantitative assessment of acute cardiac rejection. METHODS AND RESULTS: Hearts from Brown Norway rats or Lewis rats were transplanted into other Brown Norway rats. Isografts and groups of allografts either untreated or treated with cyclosporin A (CsA) at a low dose (3 mg x kg(-1) x d(-1)) or high dose (10 mg x kg(-1) x d(-1)) from 3 days before transplantation were compared at posttransplantation day 3. Echocardiography-derived left ventricular wall thickening was comparable among the 4 groups. Myocardial blood flow assessed with MCE, relating pulsing intervals with signal intensity (SI), was slightly decreased only in untreated allografts. However, myocardial SI (in gray levels) obtained after a 10-minute period allowing microbubble-leukocyte interactions after contrast injection exhibited a clear gradient in these groups (12+/-2 in untreated allografts, 9+/-5 in allografts treated with low-dose CsA, 6+/-3 in allografts treated with high-dose CsA, and 2+/-1 in isografts, P<0.001). The pattern of difference in SI among the groups agreed well with that in ED-1-positive cell (macrophage) count (25+/-7, 12+/-4, 5+/-3, and 1+/-0 cells per high-power field, respectively, P<0.001), which correlated with CD3-positive cell (T lymphocyte) count (33+/-5, 22+/-5, 9+/-4, and 1+/-0 cells per high-power field, respectively, P<0.001). CONCLUSIONS: Leukocyte-targeted MCE can noninvasively assess the degree of rejection in transplanted hearts by directly revealing the magnitude of intramyocardial infiltration of macrophages and T lymphocytes.  (+info)

Ultrasound microbubble destruction imaging in acute middle cerebral artery stroke. (3/563)

BACKGROUND AND PURPOSE: Cerebral perfusion imaging in acute stroke assists in determining the subtype and the severity of ischemia. Recent studies in perfusion models and in healthy volunteers have shown that ultrasound perfusion imaging based on microbubble destruction can be used to assess tissue perfusion. We applied ultrasound microbubble destruction imaging (MDI) to identify perfusion deficits in patients with acute middle cerebral artery (MCA) territory stroke. METHODS: Fifteen acute MCA stroke patients with sufficient transtemporal bone windows were investigated with ultrasound MDI and perfusion-weighted MRI (PWI). MDI was performed using power pulse-inversion contrast harmonic imaging. Thirty seconds after a bolus injection of the echo contrast agent SonoVue, microbubbles were destroyed using a series of high-energy pulses. Local perfusion status was analyzed in selected regions of interest by destruction curves and acoustic intensity differences (DeltaI) before and after microbubble destruction. Local perfusion status was then compared with perfusion compromise as identified on PWI. RESULTS: The mean differences of acoustic intensity from the ischemic MCA territory were significantly diminished compared with the normal hemisphere (DeltaI=2.52+/-1.75 versus DeltaI=13.79+/-7.31; P<0.001), resulting in lower slopes of microbubble destruction. PWI confirmed perfusion changes in the selected anatomical regions on time-to-peak maps in all 15 patients. CONCLUSIONS: MDI is a qualitative method that can rapidly detect perfusion changes in acute stroke. When combined with other ultrasound techniques and PWI, it may well be valuable in the care of stroke unit patients, eg, as a screening method and for follow-up assessments of perfusion deficits.  (+info)

Microbubbles and ultrasound: from diagnosis to therapy. (4/563)

The development of ultrasound contrast agents, containing encapsulated microbubbles, has increased the possibilities for diagnostic imaging. Ultrasound contrast agents are currently used to enhance left ventricular opacification, increase Doppler signal intensity, and in myocardial perfusion imaging. Diagnostic imaging with contrast agents is performed with low acoustic pressure using non-linear reflection of ultrasound waves by microbubbles. Ultrasound causes bubble destruction, which lowers the threshold for cavitation, resulting in microstreaming and increased permeability of cell membranes. Interestingly, this mechanism can be used for delivery of drugs or genes into tissue. Microbubbles have been shown to be capable of carrying drugs and genes, and destruction of the bubbles will result in local release of their contents. Recent studies demonstrated the potential of microbubbles and ultrasound in thrombolysis. In this article, we will review the recent advances of microbubbles as a vehicle for delivery of drugs and genes, and discuss possible therapeutic applications in thrombolysis.  (+info)

The powerful microbubble: from bench to bedside, from intravascular indicator to therapeutic delivery system, and beyond. (5/563)

This review discusses the development, current applications, and therapeutic potential of ultrasound contrast agents. Microbubbles containing gases act as true, intravascular indicators, permitting a noninvasive, quantitative analysis of the spatial and temporal heterogeneity of blood flow and volumes within the microvasculature. These shelled microbubbles are near-perfect reflectors of acoustic ultrasound energy and, when injected intravenously into the bloodstream, reflect ultrasound waves within the capillaries without disrupting the local environment. Accordingly, microbubble ultrasound contrast agents are clinically useful in enhancing ultrasound images and improving the accuracy of diagnoses. More recently, ultrasound contrast agents have been used to directly visualize the vasa vasorum and neovascularization of atherosclerotic carotid artery plaques, thus suggesting a new paradigm for diagnosis and treatment of atherosclerosis. Future applications of these microscopic agents include the deliver of site-specific therapy to targeted organs in the body. Medical therapies may use these microbubbles as carriers for newer therapeutic options.  (+info)

Validation of the depletion kinetic in semiquantitative ultrasonographic cerebral perfusion imaging using 2 different techniques of data acquisition. (6/563)

OBJECTIVE: To validate the potential of ultrasonographic depletion imaging for semiquantitatively visualizing cerebral parenchymal perfusion with contrast burst depletion imaging (CODIM) in comparison with phase inversion harmonic depletion imaging (PIDIM) in healthy volunteers. METHODS: Thirteen healthy adults were examined with both CODIM and PIDIM in accordance with previously described criteria. In addition to the perfusion coefficient, the time to decrease image intensity to 10% above equilibrium intensity from the initial value and the relative error (deviation of measured data from the fitted model) were evaluated to compare the reliability of both techniques in 3 different regions of interest. RESULTS: Perfusion coefficient values did not show significantly differing values in both groups (1.57-1.64 * 10(-2) s(-1) for CODIM and 1.42-1.58 * 10(-2) s(-1) for PIDIM). The relative error was significantly smaller in the PIDIM group (0.38-0.53 for CODIM and 0.18-0.25 for PIDIM; P < .002). CONCLUSIONS: Phase inversion harmonic depletion imaging proved to be more reliable than CODIM because values of the relative error were significantly lower in PIDIM even in this relatively small cohort. This is of interest because the underlying technique, phase inversion harmonic imaging, is more widely available than contrast burst imaging.  (+info)

Ultrasonic analysis of peptide- and antibody-targeted microbubble contrast agents for molecular imaging of alphavbeta3-expressing cells. (7/563)

The goal of targeted ultrasound contrast agents is to significantly and selectively enhance the detection of a targeted vascular site. In this manuscript, three distinct contrast agents targeted to the alphavbeta3 integrin are examined. The alphavbeta3 integrin has been shown to be highly expressed on metastatic tumors and endothelial cells during neovascularization, and its expression has been shown to correlate with tumor grade. Specific adhesion of these contrast agents to alphavbeta3-expressing cell monolayers is demonstrated in vitro, and compared with that of nontargeted agents. Acoustic studies illustrate a backscatter amplitude increase from monolayers exposed to the targeted contrast agents of up to 13-fold (22 dB) relative to enhancement due to control bubbles. A linear dependence between the echo amplitude and bubble concentration was observed for bound agents. The decorrelation of the echo from adherent targeted agents is observed over successive pulses as a function of acoustic pressure and bubble density. Frequency-domain analysis demonstrates that adherent targeted bubbles exhibit high-amplitude narrowband echo components, in contrast to the primarily wideband response from free microbubbles. Results suggest that adherent targeted contrast agents are differentiable from free-floating microbubbles, that targeted contrast agents provide higher sensitivity in the detection of angiogenesis, and that conventional ultrasound imaging techniques such as signal subtraction or decorrelation detection can be used to detect integrin-expressing vasculature with sufficient signal-to-noise.  (+info)

Microvascular remodeling and accelerated hyperemia blood flow restoration in arterially occluded skeletal muscle exposed to ultrasonic microbubble destruction. (8/563)

We showed previously that microbubble destruction with pulsed 1-MHz ultrasound creates a bioeffect that stimulates arteriogenesis and a chronic increase in hyperemia blood flow in normal rat muscle. Here we tested whether ultrasonic microbubble destruction can be used to create a microvascular remodeling response that restores hyperemia blood flow to rat skeletal muscle affected by arterial occlusion. Pulsed ultrasound (1 MHz) was applied to gracilis muscles in which the lateral feed artery was occluded but the medial feed artery was left intact. Control muscles were similarly occluded but did not receive ultrasound, microbubbles, or both. Hyperemia blood flow and number of smooth muscle (SM) alpha-actin-positive vessels, >30-mum arterioles, and capillaries per fiber were determined 7, 14, and 28 days after treatment. In ultrasound-microbubble-treated muscles, lateral region hyperemia blood flow was increased at all time points and restored to normal at day 28. The number of SM alpha-actin vessels per fiber was increased over control in this region at days 7 and 14 but decreased by day 28, when larger-diameter arterioles became more prevalent in the medial region. The number of capillaries per fiber was increased over control only at day 7 in the lateral region and only at days 7 and 14 in the medial region, indicating that the angiogenesis response was transient and likely did not contribute significantly to flow restoration at day 28. We conclude that ultrasonic microbubble destruction can be tailored to stimulate an arteriogenesis response that restores hyperemia blood flow to skeletal muscle in a rat model of arterial occlusion.  (+info)

Microbubbles are tiny gas-filled microspheres, typically made up of a gas core (such as air or perfluorocarbon) encapsulated by a stabilizing shell (often a phospholipid or protein). They range in size from 1 to 10 micrometers in diameter and are used in various medical applications.

In diagnostic imaging, microbubbles serve as contrast agents for ultrasound examinations. When injected into the bloodstream, they enhance the echogenicity of blood, improving visualization of vasculature, tissue perfusion, and detection of abnormalities such as tumors or lesions.

In therapeutic applications, microbubbles can be utilized in targeted drug delivery systems, where they are loaded with drugs or genes and then mechanically destroyed using ultrasound to release their cargo locally at the target site. This approach allows for more precise and controlled drug administration while minimizing systemic side effects.

Ultrasonics is a branch of physics and acoustics that deals with the study and application of sound waves with frequencies higher than the upper limit of human hearing, typically 20 kilohertz or above. In the field of medicine, ultrasonics is commonly used in diagnostic and therapeutic applications through the use of medical ultrasound.

Diagnostic medical ultrasound, also known as sonography, uses high-frequency sound waves to produce images of internal organs, tissues, and bodily structures. A transducer probe emits and receives sound waves that bounce off body structures and reflect back to the probe, creating echoes that are then processed into an image. This technology is widely used in various medical specialties, such as obstetrics and gynecology, cardiology, radiology, and vascular medicine, to diagnose a range of conditions and monitor the health of organs and tissues.

Therapeutic ultrasound, on the other hand, uses lower-frequency sound waves to generate heat within body tissues, promoting healing, increasing local blood flow, and reducing pain and inflammation. This modality is often used in physical therapy and rehabilitation settings to treat soft tissue injuries, joint pain, and musculoskeletal disorders.

In summary, ultrasonics in medicine refers to the use of high-frequency sound waves for diagnostic and therapeutic purposes, providing valuable information about internal body structures and facilitating healing processes.

Sonication is a medical and laboratory term that refers to the use of ultrasound waves to agitate particles in a liquid. This process is often used in medical and scientific research to break down or disrupt cells, tissue, or other substances that are being studied. The high-frequency sound waves create standing waves that cause the particles in the liquid to vibrate, which can lead to cavitation (the formation and collapse of bubbles) and ultimately result in the disruption of the cell membranes or other structures. This technique is commonly used in procedures such as sonication of blood cultures to release microorganisms from clots, enhancing their growth in culture media and facilitating their identification.

Contrast media are substances that are administered to a patient in order to improve the visibility of internal body structures or processes in medical imaging techniques such as X-rays, CT scans, MRI scans, and ultrasounds. These media can be introduced into the body through various routes, including oral, rectal, or intravenous administration.

Contrast media work by altering the appearance of bodily structures in imaging studies. For example, when a patient undergoes an X-ray examination, contrast media can be used to highlight specific organs, tissues, or blood vessels, making them more visible on the resulting images. In CT and MRI scans, contrast media can help to enhance the differences between normal and abnormal tissues, allowing for more accurate diagnosis and treatment planning.

There are several types of contrast media available, each with its own specific properties and uses. Some common examples include barium sulfate, which is used as a contrast medium in X-ray studies of the gastrointestinal tract, and iodinated contrast media, which are commonly used in CT scans to highlight blood vessels and other structures.

While contrast media are generally considered safe, they can sometimes cause adverse reactions, ranging from mild symptoms such as nausea or hives to more serious complications such as anaphylaxis or kidney damage. As a result, it is important for healthcare providers to carefully evaluate each patient's medical history and individual risk factors before administering contrast media.

I'm sorry for any confusion, but "Fluorocarbons" are not typically associated with medical definitions. Fluorocarbons are chemical compounds that contain carbon atoms bonded to fluorine atoms. They are often used in a variety of applications including refrigerants, fire extinguishing agents, and in the manufacturing of Teflon and other non-stick coatings.

If you have any medical terms or concepts you'd like me to define or explain, please let me know!

Ultrasonic therapy, also known as therapeutic ultrasound, is a treatment method used in physical therapy and rehabilitation that utilizes sound waves with frequencies higher than the upper limit of human hearing. In most cases, the frequency ranges from 800,000 to 2,000,000 Hz (cycles per second).

During ultrasonic therapy, a small device called a transducer is placed in direct contact with the patient's skin. The transducer emits ultrasonic waves that are primarily absorbed by soft tissues directly beneath the skin's surface, including muscles, tendons, and ligaments. These sound waves cause microscopic vibrations in the tissue molecules, which can produce various therapeutic effects:

1. Deep heating: The vibration of tissue molecules generates heat within the treated area, increasing local blood flow, reducing muscle tension, and promoting healing. This effect is particularly beneficial for treating chronic pain, muscle spasms, joint stiffness, and soft tissue injuries.
2. Cavitation: High-intensity ultrasonic waves can create tiny gas bubbles in the fluid surrounding the tissue cells. When these bubbles collapse (a process called cavitation), they generate intense localized pressure that may help break down scar tissue, reduce adhesions, and improve tissue mobility.
3. Non-thermal effects: Low-intensity ultrasonic waves can stimulate cellular processes without causing significant heating. These non-thermal effects include enhanced metabolism, increased collagen production, and improved nutrient exchange in the treated tissues, which may contribute to faster healing and tissue regeneration.

Ultrasonic therapy is generally considered safe when performed by a trained healthcare professional. However, it should be avoided in certain situations, such as over areas with malignant tumors, infected tissues, or near metal implants (due to the risk of heating). Pregnant women should also avoid therapeutic ultrasound, especially during the first trimester, due to potential risks to fetal development.

Ultrasonography, also known as sonography, is a diagnostic medical procedure that uses high-frequency sound waves (ultrasound) to produce dynamic images of organs, tissues, or blood flow inside the body. These images are captured in real-time and can be used to assess the size, shape, and structure of various internal structures, as well as detect any abnormalities such as tumors, cysts, or inflammation.

During an ultrasonography procedure, a small handheld device called a transducer is placed on the patient's skin, which emits and receives sound waves. The transducer sends high-frequency sound waves into the body, and these waves bounce back off internal structures and are recorded by the transducer. The recorded data is then processed and transformed into visual images that can be interpreted by a medical professional.

Ultrasonography is a non-invasive, painless, and safe procedure that does not use radiation like other imaging techniques such as CT scans or X-rays. It is commonly used to diagnose and monitor conditions in various parts of the body, including the abdomen, pelvis, heart, blood vessels, and musculoskeletal system.

Acoustics is a branch of physics that deals with the study of sound, its production, transmission, and effects. In a medical context, acoustics may refer to the use of sound waves in medical procedures such as:

1. Diagnostic ultrasound: This technique uses high-frequency sound waves to create images of internal organs and tissues. It is commonly used during pregnancy to monitor fetal development, but it can also be used to diagnose a variety of medical conditions, including heart disease, cancer, and musculoskeletal injuries.
2. Therapeutic ultrasound: This technique uses low-frequency sound waves to promote healing and reduce pain and inflammation in muscles, tendons, and ligaments. It is often used to treat soft tissue injuries, arthritis, and other musculoskeletal conditions.
3. Otology: Acoustics also plays a crucial role in the field of otology, which deals with the study and treatment of hearing and balance disorders. The shape, size, and movement of the outer ear, middle ear, and inner ear all affect how sound waves are transmitted and perceived. Abnormalities in any of these structures can lead to hearing loss, tinnitus, or balance problems.

In summary, acoustics is an important field of study in medicine that has applications in diagnosis, therapy, and the understanding of various medical conditions related to sound and hearing.

Drug delivery systems (DDS) refer to techniques or technologies that are designed to improve the administration of a pharmaceutical compound in terms of its efficiency, safety, and efficacy. A DDS can modify the drug release profile, target the drug to specific cells or tissues, protect the drug from degradation, and reduce side effects.

The goal of a DDS is to optimize the bioavailability of a drug, which is the amount of the drug that reaches the systemic circulation and is available at the site of action. This can be achieved through various approaches, such as encapsulating the drug in a nanoparticle or attaching it to a biomolecule that targets specific cells or tissues.

Some examples of DDS include:

1. Controlled release systems: These systems are designed to release the drug at a controlled rate over an extended period, reducing the frequency of dosing and improving patient compliance.
2. Targeted delivery systems: These systems use biomolecules such as antibodies or ligands to target the drug to specific cells or tissues, increasing its efficacy and reducing side effects.
3. Nanoparticle-based delivery systems: These systems use nanoparticles made of polymers, lipids, or inorganic materials to encapsulate the drug and protect it from degradation, improve its solubility, and target it to specific cells or tissues.
4. Biodegradable implants: These are small devices that can be implanted under the skin or into body cavities to deliver drugs over an extended period. They can be made of biodegradable materials that gradually break down and release the drug.
5. Inhalation delivery systems: These systems use inhalers or nebulizers to deliver drugs directly to the lungs, bypassing the digestive system and improving bioavailability.

Overall, DDS play a critical role in modern pharmaceutical research and development, enabling the creation of new drugs with improved efficacy, safety, and patient compliance.

Albumins are a type of protein found in various biological fluids, including blood plasma. The most well-known albumin is serum albumin, which is produced by the liver and is the most abundant protein in blood plasma. Serum albumin plays several important roles in the body, such as maintaining oncotic pressure (which helps to regulate fluid balance in the body), transporting various substances (such as hormones, fatty acids, and drugs), and acting as an antioxidant.

Albumins are soluble in water and have a molecular weight ranging from 65,000 to 69,000 daltons. They are composed of a single polypeptide chain that contains approximately 585 amino acid residues. The structure of albumin is characterized by a high proportion of alpha-helices and beta-sheets, which give it a stable, folded conformation.

In addition to their role in human physiology, albumins are also used as diagnostic markers in medicine. For example, low serum albumin levels may indicate liver disease, malnutrition, or inflammation, while high levels may be seen in dehydration or certain types of kidney disease. Albumins may also be used as a replacement therapy in patients with severe protein loss, such as those with nephrotic syndrome or burn injuries.

An air embolism is a medical condition that occurs when one or more air bubbles enter the bloodstream and block or obstruct blood vessels. This can lead to various symptoms depending on the severity and location of the obstruction, including shortness of breath, chest pain, confusion, stroke, or even death.

Air embolisms can occur in a variety of ways, such as during certain medical procedures (e.g., when air is accidentally introduced into a vein or artery), trauma to the lungs or blood vessels, scuba diving, or mountain climbing. Treatment typically involves administering oxygen and supportive care, as well as removing the source of the air bubbles if possible. In severe cases, hyperbaric oxygen therapy may be used to help reduce the size of the air bubbles and improve outcomes.

A transducer is a device that converts one form of energy into another. In the context of medicine and biology, transducers often refer to devices that convert a physiological parameter (such as blood pressure, temperature, or sound waves) into an electrical signal that can be measured and analyzed. Examples of medical transducers include:

1. Blood pressure transducer: Converts the mechanical force exerted by blood on the walls of an artery into an electrical signal.
2. Temperature transducer: Converts temperature changes into electrical signals.
3. ECG transducer (electrocardiogram): Converts the electrical activity of the heart into a visual representation called an electrocardiogram.
4. Ultrasound transducer: Uses sound waves to create images of internal organs and structures.
5. Piezoelectric transducer: Generates an electric charge when subjected to pressure or vibration, used in various medical devices such as hearing aids, accelerometers, and pressure sensors.

Molecular imaging is a type of medical imaging that provides detailed pictures of what is happening at the molecular and cellular level in the body. It involves the use of specialized imaging devices and radiopharmaceuticals (radiotracers) to visualize and measure biological processes, such as gene expression, protein expression, or metabolic activity, within cells and tissues. This information can be used to detect disease at its earliest stages, monitor response to therapy, and guide the development of new treatments.

Molecular imaging techniques include positron emission tomography (PET), single-photon emission computed tomography (SPECT), magnetic resonance imaging (MRI), and computed tomography (CT). These techniques differ in their ability to provide functional, anatomical, or molecular information about the body.

Overall, molecular imaging is a powerful tool for non-invasively visualizing and understanding biological processes at the molecular level, which can lead to improved diagnosis, treatment planning, and patient outcomes.

Microspheres are tiny, spherical particles that range in size from 1 to 1000 micrometers in diameter. They are made of biocompatible and biodegradable materials such as polymers, glass, or ceramics. In medical terms, microspheres have various applications, including drug delivery systems, medical imaging, and tissue engineering.

In drug delivery, microspheres can be used to encapsulate drugs and release them slowly over time, improving the efficacy of the treatment while reducing side effects. They can also be used for targeted drug delivery, where the microspheres are designed to accumulate in specific tissues or organs.

In medical imaging, microspheres can be labeled with radioactive isotopes or magnetic materials and used as contrast agents to enhance the visibility of tissues or organs during imaging procedures such as X-ray, CT, MRI, or PET scans.

In tissue engineering, microspheres can serve as a scaffold for cell growth and differentiation, promoting the regeneration of damaged tissues or organs. Overall, microspheres have great potential in various medical applications due to their unique properties and versatility.

Sulfur hexafluoride (SF6) is not typically a term used in medical definitions, but it is a colorless, odorless, non-flammable gas that is heavier than air. It is commonly used in the medical field for its magnetic resonance imaging (MRI) properties.

In MRI, SF6 is used as a contrast agent to improve the visualization of blood vessels and flow. When injected into a patient's bloodstream, the gas displaces oxygen in the blood, causing the blood vessels to appear darker on an MRI scan. This allows doctors to better see any abnormalities or blockages in the blood vessels.

It is important to note that sulfur hexafluoride should only be used under medical supervision and with appropriate precautions, as it can have adverse effects if not handled properly.

High-energy shock waves are intense, short pulses of mechanical energy that can be used in medical treatments. They are created by rapidly accelerating and decelerating a substance, such as gas or liquid, to produce a compression wave that travels through a medium. When this compression wave encounters a boundary between tissues with different acoustic impedances, it reflects back and creates a shock wave with high-energy peaks.

In medical terms, high-energy shock waves are often used in the treatment of various conditions, such as kidney stones (lithotripsy), musculoskeletal disorders (extracorporeal shock wave therapy or ESWT), and wound healing. The high-energy peaks of the shock waves can cause cavitation, tissue fracture, and other biological effects that can help break up kidney stones, stimulate tissue regeneration, and improve blood flow to promote healing.

It is important to note that while high-energy shock waves have therapeutic benefits, they can also cause harm if not used properly. Therefore, it is essential to receive treatment from a qualified medical professional who has experience in administering shock wave therapy.

Nanoconjugates are nanoparticles that have been joined or bonded with one or more molecules, such as proteins, drugs, or imaging agents. The process of creating nanoconjugates is called functionalization. This can alter the properties of the nanoparticle, allowing it to perform specific functions, such as targeting certain cells in the body or delivering drugs directly to those cells. Nanoconjugates have potential applications in a variety of fields, including medicine, where they may be used for drug delivery, diagnostic imaging, and sensing.

Diatrizoate Meglumine is a type of contrast medium that is used during X-ray examinations, such as CT scans and angiography. It is a radiopaque substance, which means that it contains atoms that absorb X-rays, making it possible to visualize the internal structures of the body on an X-ray image.

Diatrizoate Meglumine is a salt of diatrizoic acid, which is a type of ionic contrast medium. It works by increasing the contrast between different tissues and organs in the body, making them easier to distinguish on an X-ray image. This can help doctors to diagnose a wide range of medical conditions, including injuries, tumors, and vascular diseases.

Like all medications, Diatrizoate Meglumine can have side effects, including allergic reactions, kidney damage, and thyroid problems. It is important for patients to discuss any potential risks and benefits with their doctor before undergoing an X-ray examination that involves the use of this contrast medium.

Echocardiography is a medical procedure that uses sound waves to produce detailed images of the heart's structure, function, and motion. It is a non-invasive test that can help diagnose various heart conditions, such as valve problems, heart muscle damage, blood clots, and congenital heart defects.

During an echocardiogram, a transducer (a device that sends and receives sound waves) is placed on the chest or passed through the esophagus to obtain images of the heart. The sound waves produced by the transducer bounce off the heart structures and return to the transducer, which then converts them into electrical signals that are processed to create images of the heart.

There are several types of echocardiograms, including:

* Transthoracic echocardiography (TTE): This is the most common type of echocardiogram and involves placing the transducer on the chest.
* Transesophageal echocardiography (TEE): This type of echocardiogram involves passing a specialized transducer through the esophagus to obtain images of the heart from a closer proximity.
* Stress echocardiography: This type of echocardiogram is performed during exercise or medication-induced stress to assess how the heart functions under stress.
* Doppler echocardiography: This type of echocardiogram uses sound waves to measure blood flow and velocity in the heart and blood vessels.

Echocardiography is a valuable tool for diagnosing and managing various heart conditions, as it provides detailed information about the structure and function of the heart. It is generally safe, non-invasive, and painless, making it a popular choice for doctors and patients alike.

In medical terms, gases refer to the state of matter that has no fixed shape or volume and expands to fill any container it is placed in. Gases in the body can be normal, such as the oxygen, carbon dioxide, and nitrogen that are present in the lungs and blood, or abnormal, such as gas that accumulates in the digestive tract due to conditions like bloating or swallowing air.

Gases can also be used medically for therapeutic purposes, such as in the administration of anesthesia or in the treatment of certain respiratory conditions with oxygen therapy. Additionally, measuring the amount of gas in the body, such as through imaging studies like X-rays or CT scans, can help diagnose various medical conditions.

Serum albumin is the most abundant protein in human blood plasma, synthesized by the liver. It plays a crucial role in maintaining the oncotic pressure or colloid osmotic pressure of blood, which helps to regulate the fluid balance between the intravascular and extravascular spaces.

Serum albumin has a molecular weight of around 66 kDa and is composed of a single polypeptide chain. It contains several binding sites for various endogenous and exogenous substances, such as bilirubin, fatty acids, hormones, and drugs, facilitating their transport throughout the body. Additionally, albumin possesses antioxidant properties, protecting against oxidative damage.

Albumin levels in the blood are often used as a clinical indicator of liver function, nutritional status, and overall health. Low serum albumin levels may suggest liver disease, malnutrition, inflammation, or kidney dysfunction.

Viscosity is a physical property of a fluid that describes its resistance to flow. In medical terms, viscosity is often discussed in relation to bodily fluids such as blood or synovial fluid (found in joints). The unit of measurement for viscosity is the poise, although it is more commonly expressed in millipascals-second (mPa.s) in SI units. Highly viscous fluids flow more slowly than less viscous fluids. Changes in the viscosity of bodily fluids can have significant implications for health and disease; for example, increased blood viscosity has been associated with cardiovascular diseases, while decreased synovial fluid viscosity can contribute to joint pain and inflammation in conditions like osteoarthritis.

In medical terms, pressure is defined as the force applied per unit area on an object or body surface. It is often measured in millimeters of mercury (mmHg) in clinical settings. For example, blood pressure is the force exerted by circulating blood on the walls of the arteries and is recorded as two numbers: systolic pressure (when the heart beats and pushes blood out) and diastolic pressure (when the heart rests between beats).

Pressure can also refer to the pressure exerted on a wound or incision to help control bleeding, or the pressure inside the skull or spinal canal. High or low pressure in different body systems can indicate various medical conditions and require appropriate treatment.

Microbubbles have short half-lives on the order of minutes in circulation, which limits the treatment time. Microbubbles are ... Microbubbles have been used to deliver microRNAs, plasmids, small interfering RNA, and messenger RNA. Microbubbles do not ... Theses systems circulate longer in the body than microbubbles alone do, as this packaging method prevents the microbubble from ... Air, sulfur hexafluoride, and perfluorocarbon gases all can serve as the composition of the microbubble interior. Microbubbles ...
Microbubbles take first prize on Materials Today - the gateway for nanomaterials journal articles. ... Home » Nanomaterials » Journal articles » Microbubbles take first prize Microbubbles take first prize. Volume 13, Issue 4, Page ... This process generates microbubbles at the optimum size for CO2 absorption and subsequent delivery to an organism or process. ... The O2 produced by algae as a product can also be removed by the microbubbles, enabling further rapid growth at a rate and ...
To aid development of a safe and effective therapeutic microbubble, more insight into the microbubble-cell interaction is ... Ultrasound insonification of microbubbles can locally enhance drug delivery by increasing the cell membrane permeability. ... Internalized microbubbles caused fewer transcellular perforations and smaller pore areas than non-internalized microbubbles. In ... To aid development of a safe and effective therapeutic microbubble, more insight into the microbubble-cell interaction is ...
"These microbubbles not only influence the texture of the foam, but also how it looks. A major factor of the microbubbles is ... Microbubbles could extend shelf-life on food foams. By Stephen Daniells and Katie Bird 05-Jun-2008. - Last updated on 19-Jul- ... whereas the hydrophobic carbonyl chains lie inside the microbubbles. The observed bulging domains suggest that the surfactant ... "Interfacial polygonal nanopatterning of stable microbubbles" ​Authors: E. Dressaire, R. Bee, D.C. Bell, A. Lips, H.A. Stone ...
The production of 18F-labelled microbubbles (MBs) via the aluminium-[18F]fluoride ([18F]AlF) radiolabelling method and facile ... The production of 18F-labelled microbubbles (MBs) via the aluminium-[18F]fluoride ([18F]AlF) radiolabelling method and facile ... A kit-based aluminium-[18F]fluoride approach to radiolabelled microbubbles J. H. Teh, M. Braga, L. Allott, C. Barnes, J. ...
Microbubbles are microscopic bubbles filled with gas, with a diameter as small as one-tenth of a blood vessel. Soundwaves can ... cause microbubbles to act like balloons and allow the t ... Soundwaves can cause microbubbles to act like balloons and ... Microbubbles, liquid biopsies & 4D printers. September 24, 2020. Brain Tumour Research 2 min read Some amazing stuff here ... Lower frequencies actually cause microbubbles to expand until they explode and this discovery can be used as a tumour-treatment ...
Scientists have discovered a novel particle acceleration mechanism called microbubble implosion. ... In microbubble implosion, a phenomenon in which ions converge to a single point in space at half the speed of light plays a ... Laser-driven microbubble implosion is new way to create a tabletop particle accelerator. ... Scientists at Osaka University (Osaka, Japan) have discovered a novel particle acceleration mechanism called microbubble ...
H. Wang, X. F. Peng, D. M. Christopher and S. V. Garimella, "Jet Flows around Microbubbles in Subcooled Boiling," ASME Journal ...
Dynamics of cavitation microbubbles due to high intensity ultrasound are associated with important applications in biomedical ... Manmi, Kawa (2015). Three dimensional acoustic microbubble dynamics near rigid boundary. University of Birmingham. Ph.D. ...
Brigham Researchers Demonstrate Real-time Microbubble Monitoring for Transcranial Focused Ultrasound Published: 23 September ... Currently, due to the lack of methods to monitor and control ultrasound-induced microbubble oscillations in the brain, ... ed whether the acoustic emissions generated by oscillating microbubbles could be mapped transcranially using a clinical MRgFUS ...
Dust collecting equipment is used in processing of vitrified micro bubble CN207886819U (en) 2018-09-21. A kind of efficient ... Dust collecting equipment is used in processing of vitrified micro bubble Download PDF Info. Publication number. CN219424030U. ... Dust collecting equipment is used in processing of vitrified micro bubble Publications (1). Publication Number. Publication ... Dust collecting equipment is used in processing of vitrified micro bubble Applications Claiming Priority (1). Application ...
Background US contrast agents are gas-filled microbubbles (MBs) that can be locally destroyed by using external US. Among other ... The combination of US-triggered microbubble destruction and transarterial radioembolization is feasible with an excellent ... Combined US-triggered microbubble destruction and hepatocellular carcinoma radioembolization showed improved treatment response ... Background US contrast agents are gas-filled microbubbles (MBs) that can be locally destroyed by using external US. Among other ...
We then attached CA4 LONDs to microbubbles (MBs) and targeted this construct to VEGFR2. A reduction in tumor perfusion was ... Targeted microbubbles carrying lipid-oil-nanodroplets for ultrasound-triggered delivery of the hydrophobic drug, Combretastatin ... Lipid-Oil-Nanodroplets (LONDs); Combretastatin A4; Microbubbles; Targeting; Ultrasound trigger. Dates:. *Published (online): 22 ... 11 more authors) (2021) Targeted microbubbles carrying lipid-oil-nanodroplets for ultrasound-triggered delivery of the ...
The ah-ha go-to-market moment didnt happen for Paul Dayton in his UNC-Chapel Hill lab. It didnt occur when other scientists on campus expressed interest in using the technology that he co-developed with colleague Samantha Pattenden. Even after publishing findings in an academic journal, he still wondered: Is there commercial appeal?. But one phone call-from a multinational company-immediately transformed his uncertainty into confidence. "When our first paper came out, a large ag-tech company reached out and said, Hey, this technology we just read about sounds awesome. How can we use it in our facility?" recalled Dayton, William R. Kenan Distinguished Professor and Chair of the UNC/NCSU Joint Department of Biomedical Engineering. "That indicated real market traction, because companies were reading our paper and asking for our product.". The technology-which Dayton developed with Pattenden, an associate professor of chemical biology and medicinal chemistry at the Eshelman School of ...
Smart gold nanoparticle-stabilized microbubbles (SAuMBs) composed of a gas-filled core and shell including smart gold ... Smart Gold Nanoparticle-Stabilized Ultrasound Microbubbles as Cancer Theranostics Young Il Yoon 1 2 , Xin Pang 3 , Sungwook ... Smart Gold Nanoparticle-Stabilized Ultrasound Microbubbles as Cancer Theranostics Young Il Yoon et al. J Mater Chem B. 2018. ... Microbubble-Nanoparticle Complexes for Ultrasound-Enhanced Cargo Delivery. Chapla R, Huynh KT, Schutt CE. Chapla R, et al. ...
Microbubbles and CEUS can identify deep lymphatic vessels and better evaluate the function of lymphatic vessels. The patients ... Microbubbles and CEUS is an effective methods for identifying lymphatic vessels in lower limbs. ... Lymphography using microbubbles and contrast-enhanced ultrasound (CEUS) before lymphatic supermicrosurgery for severe ... Lymphography using microbubbles and contrast-enhanced ultrasound (CEUS) before lymphatic supermicrosurgery for severe ...
Controllable generation and manipulation of micro-bubbles in water with absorptive colloid particles by CW laser radiation. ... Controllable generation and manipulation of micro-bubbles in water with absorptive colloid particles by CW laser radiation. In ... Controllable generation and manipulation of micro-bubbles in water with absorptive colloid particles by CW laser radiation. / ... Dive into the research topics of Controllable generation and manipulation of micro-bubbles in water with absorptive colloid ...
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... ... Ultrasound-mediated delivery (USMD) of novel therapeutic agents in the presence of microbubbles is a potentially safe and ... "Enhanced gene expression of systemically administered plasmid DNA in the liver with therapeutic ultrasound and microbubbles." ... "Enhanced gene expression of systemically administered plasmid DNA in the liver with therapeutic ultrasound and microbubbles." ...
Blood-brain barrier (BBB) opening with pulsed Focused Ultrasound and Microbubbles (pFUS+MB) has been proposed as a novel ... Multiple courses of BBB opening with pulsed Focused Ultrasound and Microbubbles promotes phosphorylated Tau production. Friday ...
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"Microbubbles" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Microbubbles" by people in this website by year, and whether " ... Such characteristics of the microbubbles can be used to enhance diagnostic tests, dissolve blood clots, and deliver drugs or ... Below are MeSH descriptors whose meaning is more general than "Microbubbles".. *Analytical, Diagnostic and Therapeutic ...
Microbubbles: What are they, how do you Image them, and are they Safe? ... Preparation of Monodisperse Microbubbles using an Integrated Embedded Capillary T-Junction with Elec ...
NONAIR® Micro bubbles Separator is manufactured from corrosion resistant Stainless Steel, acid proof 316L, material and is ... NONAIR® Micro bubbles Separator is available in a great variety of connections shown below. ...
... Lingling Xu, MMa,b, Yihan Chen, MMa,b, Qiaofeng Jin, PhDa,b, Li Zhang, MDa ... Oxygen carrying microbubbles for enhanced sonodynamic therapy of hypoxic tumours. J Control Release 2015; 203:51-56. ... Breast cancer brain metastasis response to radiation after microbubble oxygen delivery in a murine model. J Ultrasound Med. ... Intravenous release of NO from lipidic microbubbles accelerates deep vein thrombosis resolution in a rat model. Thromb Res 2013 ...
Solar car park systems are a great way to turn often large car parking areas into power generation plants. These systems can off-set, or totally replace expensive grid supplied energy for nearby plant or buildings and the solar panels provide shade for parked vehicles. Also electric vehicle charging points can be supplied as an option with these systems. Many predict that this type of solar power generation will become common in car parks as electric vehicles proliferate. Large energy users such as hospitals, shopping centers, clubs, commercial buildings, universitys, airports, factories etc. can all benefit from using their car parks for power generation.. ...
One application of microbubbles in medicine is as a contrast agent to help obtain clearer ultrasound images. ... Microbubbles. Microscopic, preformed bubbles composed of varying materials that enable widespread applications. ...
Microballoons are tiny glass bubbles, that create an extremely lightweight filler when combined with resins and acrylic resins (such as Paraloid B-72). Micro-cellular, inert, non-toxic hollow glass particles. Mixed with a 60-80% wt/vol Paraloid in acetone solution it can create a strong, conservation grade filler. Reas
Solve Micro-bubbles Caused By Skimmer. So as you can see, the pipe is slightly bigger than the skimmer outlet, it sits about ... Although micro-bubbles wont cause too much of an issue for your livestock, they are unsightly and annoying. The bubbles make ... I can say that this method was quick, easy & it worked an absolute treat! My tank is now micro-bubble free! It has not had any ... As is fairly standard these days, I started reading about "micro-bubbles in an aquarium" online and I was soon able to narrow ...
T1 - Vascular lesions and s-thrombomodulin concentrations from auricular arteries of rabbits infused with microbubble contrast ... Vascular lesions and s-thrombomodulin concentrations from auricular arteries of rabbits infused with microbubble contrast agent ... Vascular lesions and s-thrombomodulin concentrations from auricular arteries of rabbits infused with microbubble contrast agent ... Vascular lesions and s-thrombomodulin concentrations from auricular arteries of rabbits infused with microbubble contrast agent ...

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