A genus of yeast-like mitosporic Saccharomycetales fungi characterized by producing yeast cells, mycelia, pseudomycelia, and blastophores. It is commonly part of the normal flora of the skin, mouth, intestinal tract, and vagina, but can cause a variety of infections, including CANDIDIASIS; ONYCHOMYCOSIS; vulvovaginal candidiasis (CANDIDIASIS, VULVOVAGINAL), and thrush (see CANDIDIASIS, ORAL). (From Dorland, 28th ed)
A superficial dermatitis occurring on skin surfaces in contact with each other, such as the axillae, neck creases, intergluteal fold, between the toes, etc. Obesity is a predisposing factor. The condition is caused by moisture and friction and is characterized by erythema, maceration, burning, and exudation.
An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.
Cytochrome P-450 Enzyme System
A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.
Cyclic hexapeptides of proline-ornithine-threonine-proline-threonine-serine. The cyclization with a single non-peptide bond can lead them to be incorrectly called DEPSIPEPTIDES, but the echinocandins lack ester links. Antifungal activity is via inhibition of 1,3-beta-glucan synthase production of BETA-GLUCANS.
Medicated dosage forms that are designed to be inserted into the rectal, vaginal, or urethral orifice of the body for absorption. Generally, the active ingredients are packaged in dosage forms containing fatty bases such as cocoa butter, hydrogenated oil, or glycerogelatin that are solid at room temperature but melt or dissolve at body temperature.
Neurotransmitter Uptake Inhibitors
Drugs that inhibit the transport of neurotransmitters into axon terminals or into storage vesicles within terminals. For many transmitters, uptake determines the time course of transmitter action so inhibiting uptake prolongs the activity of the transmitter. Blocking uptake may also deplete available transmitter stores. Many clinically important drugs are uptake inhibitors although the indirect reactions of the brain rather than the acute block of uptake itself is often responsible for the therapeutic effects.
Gene Expression Profiling
Allergy and Immunology
Differential inhibitory effects of protoberberines on sterol and chitin biosyntheses in Candida albicans. (1/280)The anti-Candida potentials of 12 Korean medicinal plants were explored: methanol extracts from Coptis rhizoma and Phellodendron amurense caused significant inhibition of growth of Candida albicans, Candida glabrata, Candida krusei and Candida parapsilosis. The predominant active components of the extracts were the protoberberines berberine and palmatine; the most potent inhibition of growth was exhibited by berberine on C. krusei (MIC <4 mg/L) and palmatine on C. parapsilosis (MIC 16 mg/L). Both berberine and palmatine inhibited the in-vivo rate of incorporation of L-[methyl-14C]methionine into C-24 of ergosterol in C. albicans (50% inhibition concentration (IC50 values), 25 microM and 300 microM, respectively); this result suggests that sterol 24-methyl transferase (24-SMT) is one of the cellular targets for the antifungal activity of the protoberberines. In-vitro 24-SMT activity in microsomes from the yeast growth form of C. albicans was inhibited by both berberine (inhibition constant (Ki) 232 microM) and palmatine (Ki 257 microM) in a non-competitive manner; inhibition of 24-SMT was more marked for the mycelial form than for the yeast growth form of this organism. Palmatine inhibited chitin synthase from both the yeast and mycelial growth phases of C. albicans in a non-competitive manner (Ki 780 microM). The effects of protoberberines, extracted from established medicinal plants, on both sterol and cell wall biosyntheses in pathogenic fungi indicate that the potential of these compounds, or their semi-synthetic derivatives, as a novel class of antifungal agents should be investigated more fully. (+info)
Comparison of the toxicity of fluconazole and other azole antifungal drugs to murine and human granulocyte-macrophage progenitor cells in vitro. (2/280)We studied the inhibitory effects on colony formation by granulocyte-macrophage colony forming units (cfu-gm) of eight azole antifungal agents in vitro. All agents, except fluconazole, inhibited colony formation dose-dependently with 50% inhibitory concentrations (IC50) in the range of 0.78-49 micromol/L in cultures of murine and human bone marrow. For human cells, the IC50 values were 0.553 mg/L for itraconazole, 1.24 mg/L for saperconazole, 2.58 mg/L for clotrimazole, 5.33 mg/L for miconazole, 6.17 mg/L for econazole, 6.27 mg/L for ketoconazole and 8.38 mg/L for oxiconazole. The IC50 of itraconazole for human cfu-gm in vitro was similar to the plasma level of this drug recommended for systemic antifungal therapy (>0.5 mg/L) thus indicating the potential clinical relevance of our data. The IC50 of ketoconazole for human cfu-gm in vitro may be exceeded by plasma levels produced in vivo by high (> or =400 mg) doses, whereas fluconazole failed to reduce colony formation by 50% even at 100 mg/L, a concentration not reached in vivo even after extremely high doses (2000 mg/day). To most of the drugs studied, murine progenitor cells seemed to be less sensitive than the human ones. There was, however, a close correlation between the murine and human log IC50 values of the drugs (r2 = 0.964, P< 0.001), suggesting that cultures of murine bone marrow may be suitable to predict the in-vitro toxicity of azole antifungals to human cfu-gm. (+info)
In-vitro resistance to azoles associated with mitochondrial DNA deficiency in Candida glabrata. (3/280)A commercially available disk diffusion procedure was used in a large-scale study to evaluate the susceptibility of a wide range of Candida isolates to polyenes and azoles. With almost all isolates of C. glabrata resistant colonies were present within the inhibition zones for the azole compounds fluconazole, ketoconazole and miconazole, and less frequently for isoconazole, econazole and clotrimazole. Ten randomly selected isolates were cloned by limiting dilution and the susceptibility of the resulting strains to polyenes and azoles was determined. All strains presented a similar susceptibility pattern with sensitivity to polyenes and the presence of resistant colonies for all azole compounds except tioconazole. For each strain and each antifungal agent, one of these resistant colonies was subcultured and studied for antifungal susceptibility. All these colonies showed similar properties regardless of which antifungal agent allowed their selection, with increased sensitivity to polyenes and cross-resistance to the azole compounds except tioconazole. Similar results were obtained on Shadomy's modified medium and on synthetic medium. Likewise, determination of MICs by the Etest method confirmed the resistance to fluconazole. Comparative growth studies revealed a respiratory deficiency in the mutants caused by mitochondrial DNA (mtDNA) deletions. In addition, 'petite' mutants were obtained from a wild-type strain by exposure to ethidium bromide, and these respiratory mutants were shown to be resistant to azoles. These results demonstrate the relationship between mtDNA deficiency and resistance to azoles, and provide an interesting model to study the mechanisms of action of these antifungal agents. (+info)
5-Fluorocytosine antagonizes the action of sterol biosynthesis inhibitors in Candida glabrata. (4/280)The concentration-dependent antagonistic interaction between 5-fluorocytosine and a sterol biosynthesis inhibitor (SBI) was studied using intact cells and cell-free extracts of Candida glabrata. 5-Fluorocytosine promoted incorporation of radioactivity into 4-desmethylsterols (P < 0.01), and enhanced the relative and absolute increases of ergosterol (P < 0.05) in C. glabrata incubated aerobically with an SBI (miconazole or amorolfine). Further aerobic incubation of C. glabrata with combinations of a nucleic acid or protein synthesis inhibitor (rifampicin or chlortetracycline) and an SBI (miconazole) promoted a similar increase in ergosterol biosynthesis. In contrast, 5-fluorocytosine reduced the incorporation of radioactivity into 4,4-dimethylsterols (P < 0.01), but had no obvious effect on the absolute ergosterol level in C. glabrata incubated statically with miconazole. In cell-free extracts of cultures previously incubated with 5-fluorocytosine, ergosterol synthesis was less sensitive to the action of miconazole. Antagonism between 5-fluorocytosine and the SBI is thus mediated by a reversal of inhibition of intracellular ergosterol synthesis. The possible mechanisms underlying antagonism between 5-fluorocytosine and SBIs that inhibit different sites of the sterol biosynthesis pathway, as well as its clinical relevance to combination therapy, are discussed. (+info)
Pharmacological characterisation of endothelium-dependent relaxation in human radial artery: comparison with internal thoracic artery. (5/280)OBJECTIVE: The aim of this study was to investigate the contribution of nitric oxide/prostanoid-independent pathways to endothelium-dependent vasorelaxation in human conduit arteries. METHODS: Rings of internal thoracic artery (ITA) and radial artery (RA) taken from patients undergoing coronary artery bypass graft surgery were suspended in 10-ml organ baths and relaxation to carbachol and bradykinin studied in the presence and absence of nitric oxide synthase (NOS) inhibitors and potassium channel blockers. RESULTS: No significant relaxation to carbachol or bradykinin was observed in ITA after NOS inhibition. In contrast, in RA less than 40% attenuation of relaxation to carbachol or bradykinin was achieved with any of the NOS inhibitors. In the presence of 20 mM K+ relaxation to carbachol and bradykinin was inhibited by 28 +/- 9% and 42 +/- 9% while in the presence of L-NAME 200 microM + 20 mM K+ relaxation was inhibited by 66 +/- 6% and 70 +/- 4% respectively in this artery. Tetraethylammonium, glibenclamide, apamin and iberiotoxin had little effect on relaxation to carbachol but charybdotoxin alone and charybdotoxin plus apamin attenuated relaxation to carbachol by 23 +/- 4% and 49 +/- 9% in RA. In the presence of L-NAME 200 microM attenuation of these relaxations were increased to 60 +/- 4% and 78 +/- 4%. CONCLUSION: In ITA relaxations to carbachol and bradykinin were mediated via nitric oxide. In contrast in RA, a conduit vessel of similar diameter, both nitric oxide-dependent and independent pathways appeared to contribute to vascular relaxation. This nitric oxide-independent relaxation involved opening of Ca2+ activated potassium channel(s). The existence of alternative pathways mediating endothelium-independent relaxation could be important under pathological conditions and may contribute to the long term survival of radial artery grafts. (+info)
Antifungal agents: mode of action, mechanisms of resistance, and correlation of these mechanisms with bacterial resistance. (6/280)The increased use of antibacterial and antifungal agents in recent years has resulted in the development of resistance to these drugs. The significant clinical implication of resistance has led to heightened interest in the study of antimicrobial resistance from different angles. Areas addressed include mechanisms underlying this resistance, improved methods to detect resistance when it occurs, alternate options for the treatment of infections caused by resistant organisms, and strategies to prevent and control the emergence and spread of resistance. In this review, the mode of action of antifungals and their mechanisms of resistance are discussed. Additionally, an attempt is made to discuss the correlation between fungal and bacterial resistance. Antifungals can be grouped into three classes based on their site of action: azoles, which inhibit the synthesis of ergosterol (the main fungal sterol); polyenes, which interact with fungal membrane sterols physicochemically; and 5-fluorocytosine, which inhibits macromolecular synthesis. Many different types of mechanisms contribute to the development of resistance to antifungals. These mechanisms include alteration in drug target, alteration in sterol biosynthesis, reduction in the intercellular concentration of target enzyme, and overexpression of the antifungal drug target. Although the comparison between the mechanisms of resistance to antifungals and antibacterials is necessarily limited by several factors defined in the review, a correlation between the two exists. For example, modification of enzymes which serve as targets for antimicrobial action and the involvement of membrane pumps in the extrusion of drugs are well characterized in both the eukaryotic and prokaryotic cells. (+info)
Miconazole represses CO(2)-induced pial arteriolar dilation only under selected circumstances. (7/280)Previous experimental findings have led to the suggestion that guanosine 3',5'-cyclic monophosphate (cGMP) plays a permissive role in hypercapnic cerebral vasodilation. However, we recently reported that the technique used to reveal a permissive role for cGMP [cGMP repletion in the presence of nitric oxide synthase (NOS) inhibition] created a situation where CO(2) reactivity was normalized but where different mechanisms (i.e., K(+) channels) participated in the response. In the present study, we examined whether that nascent K(+)-channel dependence is related in any way to an increase in the influence of the miconazole-inhibitable cytochrome P-450 epoxygenase pathway. Using intravital microscopy and a closed cranial window system in adult rats, we measured pial arteriolar diameters during normo- and hypercapnia, first in the absence and then in the presence of a neuronal NOS (nNOS) inhibitor [7-nitroindazole (7-NI)]. This was followed by suffusion of a cGMP analog and then cGMP plus miconazole. Separate groups of rats were used to evaluate whether miconazole either alone or in the presence of 8-bromoguanosine 3', 5'-cyclic monophosphate (8-BrcGMP) or its vehicle (0.1% ethanol) had any effect on CO(2) reactivity and whether miconazole affected K(+)-channel opener-induced dilations. Hypercapnic (arterial PCO(2), congruent with65 mmHg) pial arteriolar dilations, as expected, were reduced by 70-80% with 7-NI and restored with cGMP repletion. CO(2) reactivity was again attenuated after miconazole introduction. Miconazole, with and without 8-BrcGMP, and its vehicle had no influence on pial arteriolar CO(2) reactivity in the absence of nNOS inhibition combined with cGMP repletion. Miconazole alone also did not affect vasodilatory responses to K(+)-channel openers. Thus present results suggest that the nascent K(+)-channel dependence of the hypercapnic response found in our earlier study may be related to increased epoxygenase activity. The specific reasons why the pial arteriolar CO(2) reactivity gains a K(+)-channel and epoxygenase dependence only under conditions of nNOS inhibition and cGMP restoration remain to be identified. These findings again call into question the interpretations applied to data collected in studies evaluating potential permissive actions of cGMP or NO. (+info)
Down-regulation of mammalian 3-hydroxy-3-methylglutaryl coenzyme A reductase activity with highly purified liposomal cholesterol. (8/280)Chinese hamster ovary-215 cells (CHO-215) cannot synthesize C27 and C28 sterols because of a defect in the reaction that decarboxylates 4-carboxysterols [Plemenitas, A., Havel, C.M. & Watson, J.A. (1990) J. Biol. Chem. 265, 17012-17017]. Thus, CHO-215 cell growth is dependent on an exogenous metabolically functional source of cholesterol. We used CHO-215 cells to (a) determine whether highly purified (> 99.5%) cholesterol, in egg lecithin liposomes, could down-regulate derepressed 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity and if so (b) determine whether the loss in reductase catalytic activity correlated kinetically with the synthesis and accumulation of detectable oxycholesterol derivatives. Liposomal cholesterol (26-39 microM) supported maximum CHO-215 growth and initiated suppression of HMG-CoA reductase activity at concentrations greater than 50 microM. Maximum suppression (50-60%) of reductase activity was achieved with 181.3 microM liposomal cholesterol in 6 h. Also, regulatory concentrations of highly purified liposomal [3H]cholesterol were not converted (biologically or chemically) to detectable levels of oxy[3H]cholesterol derivatives during 3-6 h incubations. Lastly, a broad-spectrum cytochrome P450 inhibitor (miconazole) had no effect on liposomal cholesterol-mediated suppression of HMG-CoA reductase activity. These observations established that (a) highly purified cholesterol, incorporated into egg lecithin liposomes, can signal the down-regulation of derepressed mammalian cell HMG-CoA reductase activity and (b) if oxycholesterol synthesis was required for liposomal cholesterol-mediated down-regulation, the products had to be more potent than 24-, 25-, or 26-/27-hydroxycholesterol. (+info)
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3-Day Treatment Miconazole Nitrate Vaginal Suppositories (200 mg) and Miconazole Nitrate Cream (2%) VAGINAL ANTIFUNGAL. COMBINATION PACK Cures Most Vaginal Yeast Infections and Relieves Associated External Itching and Irritation Why should I use this product? This product contains 3 suppositories that cure most vaginal yeast infections, plus an external cream that can be used for relief of itching and irritation on the skin outside the vagina (vulva) due to a yeast infection.Do not use this product if this is the first time you have vaginal discharge, itching, burning and discomfort. See your doctor or health professional first to find out the cause of your symptoms. If a doctor has told you in the past that you had a vaginal yeast infection and you have the same symptoms now (such as vaginal discharge, itching or burning), then this product may work for you.. What is a vaginal yeast infection? A vaginal yeast infection is a common condition caused by an overgrowth of yeast (Candida) that may ...
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CONSUMER INFORMATION LEAFLET Miconazole Nitrate Vaginal Insert (1200 mg) and Miconazole Nitrate Cream (2%) VAGINAL ANTIFUNGAL. COMBINATION PACK. Cures Most Vaginal Yeast Infections and Relieves Associated External Itching and Irritation Why should I use this product? This product contains a 1-dose vaginal insert that cures most vaginal yeast infections, plus an external cream that can be used for relief of itching and irritation on the skin outside the vagina (vulva) due to a yeast infection. Do not use this product if this is the first time you have vaginal discharge, itching, burning and discomfort. See your doctor or health professional first to find out the cause of your symptoms. If a doctor has told you in the past that you had a vaginal yeast infection and you have the same symptoms now (such as vaginal discharge, itching or burning), then this product may work for you.. What is a vaginal yeast infection? A vaginal yeast infection is a common condition caused by an overgrowth of yeast ...
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Effects of Miconazole on Blood Flow - Full Text View - ClinicalTrials.gov
This study will investigate the effect of the drug miconazole on blood vessel dilation. Miconazole stops production of EDHF, a substance that causes arteries to dilate. EDHF is produced by the cells that line blood vessels.. Normal volunteers between the ages of 21 to 60 may participate in this study. Candidates will be screened for eligibility with a medical history, physical examination, electrocardiogram and routine laboratory tests. Those enrolled will be injected with miconazole to study its effects on blood vessels.. Study participants will take three aspirin tablets. After administration of a local anesthetic, small tubes will be inserted through a needle into the artery and vein of the forearm. These will be used to measure blood pressure and to draw blood samples during the study. Forearm blood flow will be measured using pressure cuffs placed on the wrist and upper arm, and a strain gauge (a rubber band device) placed around the forearm. When the cuffs are inflated, blood will flow ...
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Miconazole (Miconazole Nitrate) Teva
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where should you apply miconazole nitrate? Answered by Dr. Richard Bensinger: Site of infection: This is an antifungal given for infection of the sk...
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Daktarin Cream Miconazole Nitrate 2% 30g - Pharmacyfix
Daktarin Cream Miconazole Nitrate 2% is used to treat fungal and associated bacterial infections of skin or nails which may appear on the hands, feet or scalp.
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Miconazole topical is an antifungal medication. Miconazole topical prevents fungus from growing on your skin. Miconazole topical (for the skin) is used to treat skin infections such as athletes foot, jock itch, ringworm, tinea versicolor (a fungus that discolors the skin), and yeast infections of the skin. Miconazole...
miconazole topical | PeaceHealth
Miconazole topical is an antifungal medication. Miconazole topical prevents fungus from growing on your skin. Miconazole topical (for the skin) is used to treat skin infections such as athletes foot, jock itch, ringworm, tinea versicolor (a fungus that discolors the skin), and yeast infections of the skin. Miconazole...
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DESCRIPTION MONISTAT-DERM (miconazole nitrate 2%) Cream contains miconazole nitrate* 2%, formulated into a water-miscible base consisting of pegoxol 7 stearate, peglicol 5 oleate, mineral oil, benzoic acid, butylated hydroxyanisole and...
Miconazole: A Review of its Antifungal Activity and Therapeutic Efficacy | Semantic Scholar
Preliminary experience with oral and intravenous miconazole therapy in systemic candidiasis is promising, and the vaginal cream has produced higher cure rates than conventional nystatin vaginal tablets or amphotericin B vaginal cream, and there have been no published comparisons with other antifungal agents. SummaryMiconazole2, a synthetic imidazole derivative, is a new topical antifungal agent for use in the local treatment of vaginal, and skin and nail infections due to yeasts and dermatophytes. It is particularly active against Candida spp., Trichophyton spp., Epidermophyton spp., Microsporum spp. and Pityrosporon orbiculare (Malassezia furfur), but also possesses some activity against Gram-positive bacteria.In vaginal candidiasis, miconazole vaginal cream has produced higher cure rates than conventional nystatin vaginal tablets or amphotericin B vaginal cream. There have been no published comparisons with nystatin vaginal cream or foaming vaginal tablets - the nystatin dosage form preferred by some
Miconazole in Cryptococcosis and Systemic Candidiasis: A Word of Caution | Annals of Internal Medicine | American College of...
An article in a recent issue of this journal reported the use of intravenous miconazole in cryptococcosis (1). Use of this new antifungal drug in the treatment of systemic candidiasis as well as cryptococcosis appears to be increasing. Whereas relatively few infectious disease specialists use intravenous miconazole for these indications, we believe that this drug is used much more frequently by physicians working outside the subspecialty of infectious disease. If our impression is correct, then these groups differ in the interpretation of the meager data on the efficacy of miconazole in treating these diseases. Alternatively, some physicians may be relying ...
Utility of Miconazole Therapy for Trichosporon Fungemia in Patients with Acute Leukemia
Invasive trichosporonosis is an extremely rare mycosis, but Trichosporon fungemia (TF) in patients with hematologic malignancies has been increasingly recognized to be a fulminant and highly lethal infection. Although the utility of azole therapy has been demonstrated in several observations, little is known about the efficacy of one of azoles, miconazole (MCZ). To assess its therapeutic role, we retrospectively investigated 6 cases of TF in patients with acute leukemia receiving MCZ containing regimens. Successful outcome was obtained in 4 patients [MCZ + amphotericin B (AmB) in 2, MCZ only and MCZ + fluconazole (FLCZ) + AmB in one each], but not in 2 (MCZ + FLCZ + AmB and MCZ + FLCZ in one each). Although MCZ and AmB exhibited good in vitro activities against isolates from all patients, FLCZ had such finding from only one patient. Considering the reportedly limited utility of AmB, MCZ seemed to play a critical role even in the combination therapies for TF. Despite the release of newer
miconazole oral (buccal)
Miconazole is an antifungal medication that fights infections caused by fungus. Miconazole buccal is used to treat candida (yeast) infections inside the mouth. Miconazole buccal may also be used for purposes other than those listed in this medication guide.
Bioassay for miconazole<...
TY - JOUR. T1 - Bioassay for miconazole. AU - Espinel Ingroff, A.. AU - Shadomy, S.. AU - Fisher, J. F.. PY - 1977. Y1 - 1977. N2 - A radial diffusion bioassay for miconazole, which employs Candida stellatoidea as the indicator organism, is described. Results from three patients treated with the drug are presented.. AB - A radial diffusion bioassay for miconazole, which employs Candida stellatoidea as the indicator organism, is described. Results from three patients treated with the drug are presented.. UR - http://www.scopus.com/inward/record.url?scp=0017347862&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0017347862&partnerID=8YFLogxK. U2 - 10.1128/AAC.11.2.365. DO - 10.1128/AAC.11.2.365. M3 - Article. C2 - 848943. AN - SCOPUS:0017347862. VL - 11. SP - 365. EP - 368. JO - Antimicrobial Agents and Chemotherapy. JF - Antimicrobial Agents and Chemotherapy. SN - 0066-4804. IS - 2. ER - ...
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Warnings about miconazole and warfarin prescribed together are still not being heeded. The interaction between miconazole oral gel and warfarin is well documented but patients
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Imipramine alters the sterol profile in Leishmania amazonensis and increases its sensitivity to miconazole | Parasites &...
Imipramine, a tricyclic antidepressant widely used clinically, has other pharmacological effects, such as antileishmanial activity. Tricyclic antidepressants interact with lipid bilayers, and some studies have shown that imipramine inhibits methyltransferases. Leishmania spp. produces compounds with an ergostane skeleton instead of a cholesterol skeleton, and the inhibition of enzymes of the sterol biosynthesis pathway is an interesting therapeutic target. Among these enzymes, C-24 methyltransferase has been suggested to play an essential role, as its inhibition kills the parasites. In this context, we investigated whether imipramine alters the biosynthesis of sterols in L. amazonensis and evaluated the efficacy of imipramine alone and in combination with miconazole, a classical inhibitor of another step in this pathway. To analyze the interference of imipramine with sterol metabolism, promastigotes of L. amazonensis were cultured with medium alone, 15 or 30 μM imipramine or 4 μM miconazole, and their
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Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice. ...
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in Veterinary Dermatology (2008), 19(3), 130-133. A fully differentiated reconstructed interfollicular feline epidermis (RFE) was recently developed in vitro. It was shown to be relevant for the study of Microsporum canis-epidermal interactions. In this ... [more ▼]. A fully differentiated reconstructed interfollicular feline epidermis (RFE) was recently developed in vitro. It was shown to be relevant for the study of Microsporum canis-epidermal interactions. In this study, RFE was evaluated as a potential model for the in vitro screening of drugs against M. canis. As a preliminary step, the minimum inhibitory concentration of miconazole nitrate against M. canis IHEM 21239 grown on Sabourauds dextrose agar was determined to be 0.3 microg mL(-1). RFE grown at the air-liquid interface was cultured for 24 h in RFE culture medium, supplemented with either miconazole (range 0.1-1 microg mL(-1)) or its solvent (dimethylsulfoxide). Then, RFE was inoculated in triplicate with 1 x 10(5 )M. canis ...
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Climbazole is a topical antifungal agent commonly used in the treatment of human fungal skin infections such as dandruff and eczema. Climbazole has shown a high in vitro and in vivo efficacy against Pityrosporum ovale that appears to play an important role in the pathogenesis of dandruff. Its chemical structure and properties are similar to other fungicides such as ketoconazole and miconazole. It is most commonly found as an active ingredient in OTC anti-dandruff and anti-fungal products, including shampoos, lotions and conditioners. It may be accompanied by other active ingredients such as zinc pyrithione or triclosan. May cause localized irritation of the skin with symptoms including redness, rashes and itching. Chemical Properties of Climbazole Archived 2007-11-13 at the Wayback Machine. Wigger-Alberti, W; Kluge, K; Elsner, P (2001). Clinical effectiveness and tolerance of climbazole containing dandruff shampoo in patients with seborrheic scalp eczema. Praxis. 90 (33): ...
Antimycotics are compounds that inhibit the growth of, or kill fungi (yeasts and molds). In microbiology, antimycotics can be used in selective media formulations to inhibit the growth of fungi in environmental or food samples to facilitate the isolation of a bacterial pathogen.
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TY - CONF. T1 - Optimization of local delivery of antifungal agents in the oral cavity by a new formulation. AU - Sutera, Flavia Maria. AU - Giannola, Libero Italo. AU - De Caro, Viviana. AU - Scaturro, Anna Lisa. AU - Giandalia, Giulia. AU - Siragusa, Maria Gabriella. PY - 2012. Y1 - 2012. N2 - In recent years, with the increased use of antibiotics and immunosuppres-sive agents, there was an increased incidence of oral mycosis and Candida albicans is the most common etiologic agent in oropharyngeal candidiasis, especially in patients with HIV. The aim of this work is to develop a new dosage form containing miconazole (MN) to be topically applied on oral mucosa, allowing for a massive penetration of the drug in the tissue. The vehicle for the drug delivery was lipid microparticles incorporated in a hydrophilic gel. The lipospheres were obtained by hot melt encapsulation method using as matrix ingredients a mixtures of esters of fatty acids with higher fatty alcohols, having low melting point and ...
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... is a class of prescription drugs in India appearing as an appendix to the Drugs and Cosmetics Rules, 1945 introduced in 1945. These are drugs which cannot be purchased over the counter without the prescription of a qualified doctor.The manufacture and sale of all drugs are covered under the Drugs and Cosmetics Act and Rules. It is revised at times based on the advice of the Drugs Technical Advisory Board, part of the Central Drugs Standard Control Organization in the Ministry of Health and Family Welfare. The most recent schedule H (2006) lists 536 drugs from abacavir to zuclopenthixol. However, enforcement of Schedule H laws in India is lax, compared to the more restrictive Schedule X, for which a mandatory documentation trail must be maintained. ...
"Miconazole Vaginal: MedlinePlus Drug Information". medlineplus.gov. Retrieved 2020-08-05. "Clotrimazole Vaginal: MedlinePlus ... Example of these medications include clindamycin, terconazole, miconazole, clotrimazole, when used as a vaginal cream or ...
Treatment is topical antifungal: miconazole or econazole. Exophiala alcalophila Exophiala angulospora Exophiala attenuata ...
Marmion, LC; Desser, KB; Lilly, RB; Stevens, DA (September 1976). "Reversible thrombocytosis and anemia due to miconazole ... Miconazole, an antifungal agent Paclitaxel, a mitotic inhibitor used in cancer chemotherapy Sandimmune (cyclosporine injection ...
Miconazole has shown the best in vivo activity; however, itraconazole, fluconazole, ketoconazole and voriconazole have also ...
... p-dichlorobenzyl chloride gives miconazole. "Econazole topical Use During Pregnancy". Drugs.com. 3 September 2018. Retrieved 31 ...
Topical medications like clotrimazole, butenafine, miconazole, and terbinafine. Systemic medications (oral) like fluconazole, ... or with medicines that contains miconazole, clotrimazole, or tolnaftate. Antibiotics may be necessary to treat secondary ...
Product Information: ORAVIG(R) buccal tablets, miconazole buccal tablets. Praelia Pharmaceuticals, Inc (per FDA), Cary, NC, ...
They are treated with topical butoconazole, clotrimazole, or miconazole. Streptococcus infections are characterized by a dark ...
This effect is inhibited in the presence of the fungicide, miconazole. This species has been reported as an agent of cellulitis ... Successful control of disseminated P. marquandii infection was obtained with miconazole. The fungus has exhibited tolerance to ... Harris, L.F. (1979). Paecilomyces cellulitis in a renal transplant patient: successful treatment with intravenous miconazole. ...
Treatment is typically with antifungal creams such as clotrimazole or miconazole. If the scalp is involved, antifungals by ... Antifungal treatments include topical agents such as miconazole, terbinafine, clotrimazole, ketoconazole, or tolnaftate applied ...
Currently, the final rinse uses a surfactant, and miconazole, an anti-fungal agent. Drying: Drying in a dust-free environment. ...
... is a topical antifungal drug product that contains the active ingredients miconazole nitrate, zinc oxide, and white ... The formulation is 0.25% Miconazole nitrate, 15% Zinc oxide, and 81.35% White petrolatum. It is available by prescription only ...
A combined regimen of propamidine, miconazole nitrate, and neomycin has also been suggested. Due to the potential for negative ...
Topical antifungal imidazoles such as ketoconazole, itraconazole, and miconazole may also be used. Imidazoles are generally ...
Gonçalves AQ, Viana Jda C, Pires EM, Bóia MN, Coura JR, Silva EF (2007). "The use of the antifungal agent miconazole as an ... Miconazole and quinacrine have been reported as effective agents against Blastocystis growth in-vitro. Rifaximin, and ...
see above) and Nexium (omeprazole), the antimycotics Daktarin (miconazole), Fungarest (ketoconazole) and Travogen (isoconazole ...
... s belong to the class of azole antifungals, which includes ketoconazole, miconazole, and clotrimazole. For comparison ...
Vaginal yeast infection
... miconazole, nystatin, tioconazole, terconazole. Candidal vulvovaginitis in pregnancy should be treated with intravaginal ...
Active substance: miconazole) Nizoral (against dandruff, Active substance: ketoconazole) Duragesic (fentanyl patch for pain ... miconazole) Vermox (mebendazole) Nizoral (ketoconazole) (Removed in 2005) Risperdal (risperidone) Sirturo (bedaquiline) - an ...
Its chemical structure and properties are similar to other fungicides such as ketoconazole and miconazole. It is most commonly ...
... , along with miconazole, has been found to act as an antagonist of the glucocorticoid receptor. Ketoconazole is a ... July 2006). "Ketoconazole and miconazole are antagonists of the human glucocorticoid receptor: consequences on the expression ...
... nystatin or miconazole). For breastfeeding mothers topical miconazole is the most effective treatment for treating candidiasis ...
Infection - Simple English Wikipedia, the free encyclopedia
Antifungals like miconazole and fluconazole treat infections from fungus. Anti-parasitic medicines like Praziquantel and ...
Griseofulvin, clotrimazole and miconazole are antimycotic agents that are used to treat M. nanum and T. rubrum. Of three human ... Griseofulvin, clotrimazole, miconazole, enilconazole and many herbal treatments, such as extracts from Azadirachta indica, ... cases of M. nanum infection reported in 1986, all resolved with treatments by griseofulvin, clotrimazole or miconazole cream. ...
In combination with miconazole it has been studied as a possible treatment for infections of Clostridium difficile. Fukase, ...
Other topical antifungal agents such as clotrimazole, miconazole, terbinafine, or zinc pyrithione can lessen symptoms in some ...
It is unclear if other antifungals, such as miconazole, are equally effective as they have been poorly studied. Other options ... miconazole, bifonazole, sertaconazole, clotrimazole, flutrimazole, ciclopirox, terbinafine, butenafine, selenium sulfide, and ...
First-line therapies include nystatin, ketaconazole or miconazole applied to the nipple and given by mouth to the baby. Strict ...
But the dog was treated with oral itraconazole and topical miconazole, which cured the dog after three weeks of medication. In ...
... has part (R)-miconazole (CHEBI:82894) miconazole (CHEBI:6923) has part (S)-miconazole (CHEBI:82897) ... miconazole (CHEBI:6923) is a imidazole antifungal drug (CHEBI:87069) miconazole (CHEBI:6923) is a racemate (CHEBI:60911) ... miconazole (CHEBI:6923) has role antineoplastic agent (CHEBI:35610) miconazole (CHEBI:6923) has role ergosterol biosynthesis ... miconazole (CHEBI:6923) has role glucocorticoid receptor antagonist (CHEBI:82891) miconazole (CHEBI:6923) is a conazole ...
Miconazole | drug | Britannica.com
... or miconazole (Micatin), which can be purchased over the counter. Prescription-strength topicals, such as clotrimazole, may ... Other articles where Miconazole is discussed: athletes foot: Treatment: …such as terbinafine (Lamisil) ... such as terbinafine (Lamisil) or miconazole (Micatin), which can be purchased over the counter. Prescription-strength topicals ...
miconazole nitrate (CHEBI:6924)
... miconazole nitrate (CHEBI:82886) miconazole nitrate (CHEBI:6924) has part (S)-miconazole nitrate (CHEBI:82888) miconazole ... miconazole nitrate (CHEBI:6924) is a imidazole antifungal drug (CHEBI:87069) miconazole nitrate (CHEBI:6924) is a racemate ( ... miconazole nitrate (CHEBI:6924) has role glucocorticoid receptor antagonist (CHEBI:82891) miconazole nitrate (CHEBI:6924) is a ... miconazole nitrate (CHEBI:6924) has role antifungal agent (CHEBI:35718) miconazole nitrate (CHEBI:6924) has role antineoplastic ...
Miconazole - Wikipedia
The solubilities of miconazole nitrate powder are 0.03% in water, 0.76% in ethanol and up to 4% in acetic acid. Miconazole is ... These interactions are not relevant for miconazole that is applied to the skin. Miconazole is contraindicated for people who ... "Miconazole topical Use During Pregnancy". Drugs.com. 3 September 2019. Retrieved 20 August 2020. "Miconazole Nitrate". The ... In the UK, miconazole may be used to treat neonatal oral thrush, while the alternative nystatin is only licensed for patients ...
Miconazole Vaginal: MedlinePlus Drug Information
Miconazole Vaginal: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Vaginal miconazole is used to treat vaginal yeast infections in adults and children 12 years of age and older. Miconazole is in ... Before using vaginal miconazole,. *tell your doctor and pharmacist if you are allergic to miconazole, any other medications, or ... Use miconazole exactly as directed. Do not use more or less of it or use it more often than directed on the package or ...
Miconazole Buccal: MedlinePlus Drug Information
Miconazole Buccal: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Before using buccal miconazole,. *tell your doctor and pharmacist if you are allergic to miconazole, milk protein concentrate, ... Buccal miconazole comes as a tablet to apply to the upper gum of the mouth. It is usually applied once a day in the morning, ... To use buccal miconazole, follow these steps: *Find the area on the upper gum above your left and right incisor teeth (the ...
Contraindications for Miconazole Nitrate Topical
Daktarin Aktiv (miconazole)
... Daktarin Aktiv cream and spray powder both contain the active ingredient miconazole. Miconazole is ... Daktarin Aktiv cream and spray powder both contain the active ingredient miconazole. Miconazole is an antifungal medicine used ... Miconazole is unlikely to be absorbed through the skin in significant amounts, however, it is not known if the medicine passes ... Miconazole is unlikely to be absorbed through the skin in sufficient amounts to affect other medicines that you are taking by ...
Daktarin cream (miconazole)
Miconazole is an antifungal medicine used to treat infections with fungi and yeasts. ... Daktarin cream (miconazole). Daktarin cream contains the active ingredient miconazole. Miconazole is an antifungal medicine ... Daktarin cream contains the active ingredient miconazole. Miconazole kills fungi and yeasts by interfering with their cell ... Miconazole is unlikely to be absorbed through the skin in significant amounts, however, it is not known if the medicine passes ...
Ketoconazole Cream (Nizoral) vs. Miconazole (Monistat)
Miconazole is also used to treat vaginal fungal infections. ... Miconazole. Miconazole vaginal cream and suppositories are for ... and miconazole (Monistat) are antifungal medications prescribed to treat fungal infections such as athletes foot and ringworm ... Brand names for miconazole include Monistat, M-Zole, and Micatin.. *Side effects of ketoconazole and miconazole that are ... Miconazole (Monistat). *Ketoconazole cream vs. miconazole: Whats the difference?. *What is ketoconazole cream? What is ...
Miconazole - definition of miconazole by The Free Dictionary
miconazole synonyms, miconazole pronunciation, miconazole translation, English dictionary definition of miconazole. n. A broad- ... Related to miconazole: ketoconazole, nystatin, miconazole nitrate. mi·con·a·zole. (mĭ-kŏn′ə-zōl′). n.. A broad-spectrum ... Miconazole - definition of miconazole by The Free Dictionary https://www.thefreedictionary.com/miconazole ... Topical 2% miconazole bid for 2 weeks has resulted in clearance rates as high as 88%.. Persistent rash on feet: The diagnosis ...
Miconazole (Topical Route) Precautions - Mayo Clinic
Miconazole belongs to the group of medicines called antifungals. Topical miconazole is used to treat some types of fungus ... To use the powder form of miconazole:. * If the powder is used on the feet, sprinkle it between the toes, on the feet, and in ... When miconazole is used to treat certain types of fungus infections of the skin, an occlusive dressing (airtight covering, such ... Although there is no specific information comparing use of topical miconazole in the elderly with use in other age groups, this ...
Miconazole/hydrocortisone/terbinafine | SpringerLink
Saunte DML, et al. Emerging terbinafine resistance in Trichophyton: Clinical characteristics, squalene epoxidase gene mutations, and a reliable EUCAST method for detection. Antimicrobial Agents and Chemotherapy 63: 1-24, No. 10, Part E01126-19, Oct 2019. Available from: URL: http://doi.org/10.1128/AAC.01126-19 - Denmark ...
Interaction between warfarin and topical miconazole cream | The BMJ
Miconazole is a broad spectrum antifungal agent. When co-administered with warfarin it may increase the anticoagulant effect of ... Miconazole oral gel potentiates warfarin anticoagulant activity.Thromb Haemost2000; 83:794-795. ... He was admitted to hospital, where his warfarin and miconazole were withdrawn and he was given fresh frozen plasma. His ... In the absence of other explanations, we assume that topical absorption of miconazole had occurred, which led to loss of ...
Walgreens Miconazole 7 Vaginal Antifungal Cream | Walgreens
Get free shipping at $35 and view promotions and reviews for Walgreens Miconazole 7 Vaginal Antifungal Cream ... Miconazole Nitrate 100 mg per Applicator. *Helps Cure Most Vaginal Yeast Infections & Relieve Associated External Itching & ... Walgreens Miconazole 7 Vaginal Antifungal Cream at Walgreens. ... Walgreens Miconazole 7 Vaginal Antifungal Cream1.59 oz. 3.0(16) ...
Miconazole (Topical) (Professional Patient Advice) - Drugs.com
Professional guide for Miconazole (Topical). Includes: pharmacology, pharmacokinetics, contraindications, interactions, adverse ... Hypersensitivity to miconazole or any component of the formulation. Dosing: Adult. Tinea corporis: Topical: Apply twice daily ... Miconazole Nitrate. Dosage Forms. Excipient information presented when available (limited, particularly for generics); consult ... Miconazole 3 Combo Pack: Cream, topical: 2% (9 g) and Suppository, vaginal: 200 mg (3s) [contains benzoic acid] ...
Miconazole (Oral) (Professional Patient Advice) - Drugs.com
Professional guide for Miconazole (Oral). Includes: pharmacology, pharmacokinetics, contraindications, interactions, adverse ... Miconazole (Oral) may increase the serum concentration of Sulfonylureas. Monitor therapy. Warfarin: Miconazole (Oral) may ... azole antifungals clotrimazole, fluconazole, ketoconazole, Diflucan, Nizoral, miconazole. Oral Thrush nystatin, clotrimazole, ... Miconazole Nitrate. Dosage Forms. Excipient information presented when available (limited, particularly for generics); consult ...
DailyMed - ANTIFUNGAL- miconazole nitrate cream
Miconazole (Buccal Mucosa Route) Before Using - Mayo Clinic
Walgreens Miconazole 3 Vaginal Antifungal Combination Pack | Walgreens
DailyMed - MICONAZOLE 3- miconazole nitrate kit
miconazole nitrate 200 MG Vaginal Insert. SCD. 3. 992766. miconazole nitrate 200 MG Vaginal Insert (3) / miconazole nitrate 2 ... miconazole 3 Day (3 - 200 MG miconazole nitrate vaginal insert / 9 GM miconazole nitrate 2 % topical vaginal cream). SY. ... MICONAZOLE NITRATE (UNII: VW4H1CYW1K) (MICONAZOLE - UNII:7NNO0D7S5M) MICONAZOLE NITRATE. 2 g in 100 g. ... MICONAZOLE 3- miconazole nitrate kit. To receive this label RSS feed. Copy the URL below and paste it into your RSS Reader ...
Miconazole (Oral) - Oravig | Davis's Drug Guide
Find information on Miconazole (Oral) - Oravig in Daviss Drug Guide including dosage, side effects, interactions, nursing ... miconazole (oral) is a topic covered in the Daviss Drug Guide. To view the entire topic, please sign in or purchase a ... "Miconazole (oral)." Daviss Drug Guide, 16th ed., F.A. Davis Company, 2019. Washington Manual, www.unboundmedicine.com/ ... washingtonmanual/view/Davis-Drug-Guide/109629/all/miconazole__oral_. Quiring C, Sanoski CA, Vallerand AH. Miconazole (oral). ...
Reminder: Warfarin and Miconazole Oral Gel
... miconazole oral gel added to their treatment regimes. The addition of miconazole oral gel resulted in an increased INR and ... Miconazole inhibits the metabolism of warfarin through the liver by inhibiting the cytochrome P450 isoenzyme, CYP2C92. This can ... Miconazole oral gel is a commonly supplied pharmacist-only medicine, as well as being available on prescription. ... If the concomitant use of miconazole oral gel and warfarin is necessary, the patients INR should be carefully monitored and ...
miconazole oral (buccal) | Cigna
Miconazole buccal is a pill placed between your check and gum to treat candida (yeast) infections inside the mouth. Miconazole ... Miconazole is an antifungal medicine that fights infections caused by fungus. ... Miconazole is an antifungal medicine that fights infections caused by fungus.. Miconazole buccal is a pill placed between your ... What are the possible side effects of miconazole buccal?. Get emergency medical help if you have signs of an allergic reaction ...
Molecular Expressions: Pharmaceuticals Wallpaper for Windows Magnesium Chloride - Miconazole
Search of: 'Hepatitis C' | 'Miconazole' - List Results - ClinicalTrials.gov
Miconazole (Topical): Pediatric Medication | Memorial Sloan Kettering Cancer Center
Miconazole 3; Miconazole 3 Combo Pack [OTC]; Miconazole 7 [OTC]; Miconazole Antifungal [OTC]; Micro Guard [OTC] [DSC]; Podactin ... Miconazole (Topical) - Last updated on August 5, 2020. ©2020 Memorial Sloan Kettering Cancer Center. ... GoodSense Miconazole 1 [OTC]; Lotrimin AF Deodorant Powder [OTC]; Lotrimin AF Jock Itch Powder [OTC]; Lotrimin AF Powder [OTC ...
... prevents fungus from growing on your skin. Miconazole topical (for the skin) is used to treat skin ... What is miconazole topical?. Miconazole topical is an antifungal medication. Miconazole topical prevents fungus from growing on ... Miconazole topical is not for use in the vagina or rectum. Wash your hands before and after using this medication, unless you ... It is not known whether miconazole topical will harm an unborn baby. Do not use this medicine without a doctors advice if you ...
Ralphs - Kroger® Miconazole 3 Day Suppositories, 3 ct
miconazole vaginal | UW Health | Madison, WI
Miconazole vaginal is used to treat vaginal candida (yeast) infections. Miconazole vaginal may also be used for purposes not ... Miconazole is an antifungal medication. It prevents fungus from growing. ... Miconazole vaginal is used to treat vaginal candida (yeast) infections.. Miconazole vaginal may also be used for purposes not ... Miconazole may damage a condom or diaphragm. Use another form of birth control while using miconazole vaginal. ...
MonistatTopical miconazoleSuppositoriesMedicinesFormulationZoleMicatinDaktacortSuppositoryEffects of MiconazoleHydrocortisoneYeastDaktarinMedicationDosageCoated with miconazole nitrateAntifungalsFormulationsFungusPowder1200 mgCandidaActive ingredient miconazoleContaining miconazole nitrateTreat vaginalVaginaForm of miconazoleAmounts of miconazoleActivity of miconazoleDelivery of miconazoleWarfarin and miconazoleInteract with miconazoleKnown whether miconazoleBroad spectrum antifungalFluconazole and MiconazoleConcentrations of miconazoleMedicationsInteractionsSprayAthlete's footCandidiasisOintmentFungal infectionTineaDrug miconazoleEquate miconazoleBuccal miconazoleContain miconazoleOral gel and warfarinYounger than 16 yearsEfficacySide effectsMucoadhesive buccal tablet
- Brand names for miconazole include Monistat , M-Zole , and Micatin . (medicinenet.com)
- Ketoconazole cream is an antifungal medication in the same family of drugs as fluconazole ( Diflucan ), itraconazole ( Sporanox ), and miconazole (Micatin, Monistat). (medicinenet.com)
- Miconazole, sold under the brand name Monistat among others, is an antifungal medication used to treat ring worm, pityriasis versicolor, and yeast infections of the skin or vagina. (wikipedia.org)
- You should not use this medicine if you are allergic to miconazole (Monistat, Vusion, and others) or if you are allergic to milk proteins. (cigna.com)
- MONISTAT-DERM (miconazole nitrate 2%) Cream contains miconazole nitrate* 2%, formulated into a water-miscible base consisting of pegoxol 7 stearate, peglicol 5 oleate, mineral oil, benzoic acid, butylated hydroxyanisole and purified water. (egeneralmedical.com)
- I can't say for sure without seeing it, but the miconazole cream I use is the generic for "Monistat 7. (wisegeek.com)
- One of the most popular topical antifungal agents is miconazole, which is available in both over-the-counter and prescription strengths under a variety of trade names, including Micatin and Monistat. (fsu.edu)
- In fact, some national health plans now recommend OTC treatment with miconazole/MONISTAT® before a prescription. (monistat.com)
- MONISTAT® 1-Day Simple Therapy™ (tioconazole 6.5% ointment) is an option for patients who are sensitive to high concentrations of miconazole or the ingredients found in cream formulations. (monistat.com)
- Generic drug Miconazole is considered just as safe and effective as its brand-name equivalents such as Monistat and Daktarin. (internationaldrugmart.com)
- Did you know that buying the generic drug Miconazole from IDM is much cheaper than buying the Monistat or Daktarin. (internationaldrugmart.com)
- Topical miconazole is used to treat some types of fungus infections. (mayoclinic.org)
- Although there is no specific information comparing use of topical miconazole in children with use in other age groups, this medicine is not expected to cause different side effects or problems in children than it does in adults. (mayoclinic.org)
- However, he had been applying topical miconazole cream for a fungal infection over the right groin area during the previous two weeks. (bmj.com)
- Single-dose oral fluconazole versus single-dose topical miconazole for the treatment of acute vulvovaginal candidosis. (monistat.com)
- Since topical miconazole and clotrimazole are not well absorbed, they are unlikely to be a concern for the pregnancy. (mothertobaby.org)
- 2004. Population-based case-control teratologic study of topical miconazole. (mothertobaby.org)
- Continue using miconazole vaginal cream or suppositories even if you get your period during treatment. (medlineplus.gov)
- tell your doctor and pharmacist if you are allergic to miconazole, any other medications, or any of the ingredients in miconazole external cream, vaginal cream, or suppositories. (medlineplus.gov)
- Miconazole vaginal cream and suppositories are for use only in the vagina. (medicinenet.com)
- Potentiation of warfarin's hypoprothrobinaemic effect with miconazole vaginal suppositories. (bmj.com)
- Miconazole vaginal cream, ovules, or suppositories should be inserted high into the vagina once daily using the applicator(s) provided for 1, 3, or 7 days, depending on the specific product being used. (medbroadcast.com)
- Systemic exposure to NES and EE released from the CVR increased with single or multiple doses of miconazole suppositories but not with multiple dose cream. (popcouncil.org)
- Miconazole vaginal suppositories were associated with increased systemic levels of NES and EE, while systemic exposure with miconazole vaginal cream was comparable to no-miconazole exposure. (popcouncil.org)
- Co-administration of miconazole suppositories with the investigational NES/EE CVR led to higher systemic exposure of both hormones, while co-administration with miconazole cream did not affect hormone levels. (popcouncil.org)
- Miconazole belongs to the group of medicines called antifungals. (mayoclinic.org)
- The medicines below all contain the following active ingredient(s): miconazole. (healthdirect.gov.au)
- Before you take a medication for a particular ailment, you should inform the health expert about intake of any other medications including non-prescription medications, over-the-counter medicines that may increase the effect of Miconazole, and dietary supplements like vitamins, minerals and herbal, so that the doctor can warn you of any possible drug interactions. (internationaldrugmart.com)
- Like other medicines, Miconazole can cause some side effects. (internationaldrugmart.com)
- Miconazole may affect the way other medicines work, and other medicines may affect how miconazole works. (rxwiki.com)
- Fuji Hunt also includes miconazole as a final rinse additive in their formulation of the C-41RA rapid access color negative developing process. (wikipedia.org)
- ORAVI is a novel once-daily mucoadhesive tablet formulation of the antifungal agent miconazole for the treatment of oropharyngeal candidiasis (OPC), a condition that occurs frequently in immunocompromised patients due to HIV, malignant tumours, etc. (thefreedictionary.com)
- A formulation for preparing Miconazole 1% Nasal Irrigation/Spray. (ijpc.com)
- Furthermore, the formulation of MN-SLNs enhanced the antifungal activity compared with miconazole capsules. (dovepress.com)
- Improved vaginal retention and enhanced antifungal activity of miconazole microsponges gel: Formulation development and in vivo therapeutic efficacy in rats. (annals.org)
- Women utilizing the NES/EE CVR may be advised to use an oral formulation or miconazole cream rather than suppository to treat vaginal candidiasis. (popcouncil.org)
- This study has shown that the developed microstructured lipid-based formulation could be employed for improved physicochemical performance and safe intravaginal delivery of miconazole nitrate. (ajol.info)
- For dermatological conditions associated with bacteria and when a deodorizing formulation may be of benefit, use Davis Chlorhexidine Shampoo with 2% Chlorhexidine Gluconate in conjunction with Davis Miconazole Shampoo. (petstruly.com)
- MICONAZOLE (mi KON a zole) is an antifungal medicine. (ahealthyme.com)
- such as terbinafine (Lamisil) or miconazole (Micatin), which can be purchased over the counter. (britannica.com)
- Fass environmental information for Daktacort (hydrocortisone, miconazole) for miconazole (downloaded 2018-06-27). (janusinfo.se)
- Miconazole (Daktarin, Daktacort) is an antifungal indicated for prevention and treatment of various infections of the mouth, throat, skin, nails, or genitals. (www.gov.uk)
- Daktacort ( miconazole nitrate ) is a topical fungicide that also has antibacterial and antiparasitic properties. (kiwidrug.com)
- Vaginal miconazole comes as a cream or suppository to be inserted into the vagina. (medlineplus.gov)
- Can I use the miconazole suppository while having the Merina? (healthtap.com)
- Three different miconazole formulations (single dose suppository, multiple dose suppository or multiple dose cream) were administered in a single dose on day 8 or multiple doses on days 8-10 after CVR insertion. (popcouncil.org)
Effects of Miconazole7
- Side effects of miconazole that are different from ketoconazole include skin irritation and burning. (medicinenet.com)
- If they do occur, the side effects of Miconazole are most likely to be minor and temporary. (internationaldrugmart.com)
- It is pertinent to note that side effects of Miconazole cannot be anticipated. (internationaldrugmart.com)
- If any side effects of Miconazole develop or change in intensity, the doctor should be informed as soon as possible. (internationaldrugmart.com)
- What are the effects of miconazole cream when taken orally? (healthtap.com)
- Common side effects of miconazole include diarrhea, change in taste, and headache. (rxwiki.com)
- These are not all the possible side effects of miconazole. (rxwiki.com)
- McKinley OTC - Product line of over-the-counter active ingredients for topical applications with anti-inflammatory (Hydrocortisone Base and Acetate), anti-fungal ( Miconazole Nitrate and Ketoconazole), anesthetic (Benzocaine, and Lidocaine HCL and Base), and anti-acne (Salicylic Acid) benefits. (thefreedictionary.com)
- Vaginal miconazole is used to treat vaginal yeast infections in adults and children 12 years of age and older. (medlineplus.gov)
- Miconazole buccal is a pill placed between your check and gum to treat candida (yeast) infections inside the mouth. (cigna.com)
- Miconazole topical (for the skin) is used to treat skin infections such as athlete's foot, jock itch, ringworm, tinea versicolor (a fungus that discolors the skin), and yeast infections of the skin. (adventisthealthcare.com)
- Miconazole is commonly prescribed to treat various infections, including vaginal yeast infections, jock itch and athlete's foot. (clinicaltrials.gov)
- Miconazole nitrate is a topical medication designed to treat various fungal infections, including vaginal yeast infections, athlete's foot, ringworm , and jock itch . (wisegeek.com)
- Among the conditions that are commonly treated with miconazole are ringworm, athlete s foot, tinea versicolor, jock itch, and yeast infections. (fsu.edu)
- Miconazole(Oravig) generic Tolomate is an anti-fungal agent, prescribed for various skin infections such as athlete's foot and jock itch and also for vaginal yeast infections. (medindia.net)
- Miconazole works by killing the overgrowth of yeast that is causing the infection. (medbroadcast.com)
- If you doctor tells you to stay on Diflucan and/or Miconazole long term then that choice is yours, but this web site is just to educate you in the fact that yeast infections can be prevented without any long term drug use. (natural-remedies-for-you.com)
- Miconazole treats yeast infections. (rxwiki.com)
- Miconazole is a prescription medication used to treat fungal yeast infections of the mouth or the throat. (rxwiki.com)
- Miconazole and zinc oxide topical ointment is not for use on general diaper rash without a related yeast infection. (uncmedicalcenter.org)
- Davis Miconazole Shampoo For Dogs, Cats, Puppies & Kittens is an antifungal shampoo formulated to treat fungal skin infections such as ringworm, superficial skin infections caused by yeast and scaling due to seborrhea. (petstruly.com)
- Like miconazole, it is placed in the vagina for the treatment of vaginal yeast infections. (mothertobaby.org)
- Daktarin Aktiv cream and spray powder both contain the active ingredient miconazole. (netdoctor.co.uk)
- Daktarin cream contains the active ingredient miconazole. (netdoctor.co.uk)
- Oral treatment: (brand names Daktarin in UK, Fungimin Oral Gel in Bangladesh): Oral gel 24 mg/ml (20 mg/g) Oravig 50 mg once daily buccal tablet: In 2010, the U.S. Food and Drug Administration approved Oravig (miconazole) buccal tablets once daily for the local treatment of oropharyngeal candidiasis, more commonly known as thrush, in adults and children age 16 and older. (wikipedia.org)
- Daktarin Cream with Miconazole is an effective external treatment for fungal infections. (chemistdirect.co.uk)
- Miconazole is an antifungal medication related to fluconazole (Diflucan), ketoconazole (Nizoral), itraconazole (Sporanox), and clotrimazole (Lotrimin, Mycelex). (medicinenet.com)
- Miconazole buccal may also be used for purposes not listed in this medication guide. (cigna.com)
- Miconazole topical is an antifungal medication. (adventisthealthcare.com)
- Miconazole is an antifungal medication. (uwhealth.org)
- Before using miconazole nitrate , consumers should be aware of the possible side effects associated with using this medication. (wisegeek.com)
- Consumers who choose to use miconazole for hair growth should follow all dosage instructions included with the medication. (wisegeek.com)
- Do not use this medication if you are allergic to miconazole or any ingredients of the medication. (medbroadcast.com)
- If your physician has instructed or directed you to apply Miconazole medication in a regular schedule and you have missed a dose of this medicine, apply it as soon as you remember. (internationaldrugmart.com)
- Betamethasone Valerate-Gentamicin-Miconazole Nitrate is a topical antibacterial and antifungal medication used to treat various inflammatory skin conditions. (internationaldrugmart.com)
- Miconazole and zinc oxide topical may also be used for purposes not listed in this medication guide. (uncmedicalcenter.org)
- What is the dosage of ketoconazole vs. miconazole? (medicinenet.com)
- What is the recommended dosage of Miconazole? (internationaldrugmart.com)
- The dosage of Miconazole prescribed to each patient will vary. (internationaldrugmart.com)
- Miconazole MBT was approved in 11 countries and is currently being marketed in several EU territories including France, Germany and the UK under the trade name Loramyc ((R)) . While miconazole MBT would be the first miconazole treatment available in oral form in the U.S., other dosage forms of miconazole have been marketed around the world. (bio-medicine.org)
Coated with miconazole nitrate1
- tampons, coated with miconazole nitrate 100 mg. (intox.org)
- Usually, denture stomatitis is treated with antifungals ( miconazole , nystatin, and fluconazole), but studies show cases of treatment failure and rapid recurrence after discontinuation of treatment, especially if not accompanied by proper prosthesis hygiene . (thefreedictionary.com)
- There is no information regarding cross-reactivity between miconazole and other azole antifungals. (drugs.com)
- Miconazole belongs to a group of drugs called azole antifungals which work by killing fungi by interfering with their cell membranes. (rxwiki.com)
- 2 An interaction of warfarin with miconazole oral gel and pessary formulations has also been reported. (bmj.com)
- On the basis of this and reports about other topical formulations, patients taking warfarin should be advised to avoid any form of treatment with miconazole. (bmj.com)
- To evaluate the effects of concurrent administration of three vaginal miconazole nitrate formulations on the absorption and exposure of Nestorone® (segesterone acetate) and ethinyl estradiol from a novel contraceptive vaginal ring (NES/EE CVR). (popcouncil.org)
- In this study, miconazole and fluconazole were compounded separately in RECURA compounding cream, and they were tested at different time points (0, 7, 14, 28, 45, 60, 90, and 180 days) to determine the beyond-use date of those formulations. (ijpc.com)
- The beyond-use date testing of both formulations (10% miconazole in RECURA and 10% fluconazole in RECURA) proved them to be physically, chemically, and microbiologically stable under International Conference of Harmonisation controlled room temperature (25°C ± 2°C/60% RH ±5%) for at least 180 days from the date of compounding. (ijpc.com)
- When miconazole is used to treat certain types of fungus infections of the skin, an occlusive dressing (airtight covering, such as kitchen plastic wrap) should not be applied over this medicine. (mayoclinic.org)
- Miconazole is an antifungal medicine that fights infections caused by fungus. (cigna.com)
- Miconazole topical prevents fungus from growing on your skin. (adventisthealthcare.com)
- www.natural-remedies-for-you.com is not in any way condemning the use of Fluconazole and Miconazole as cures to kill fungus. (natural-remedies-for-you.com)
- Miconazole and zinc oxide topical (for the skin) is a combination antifungal medicine that fights infections caused by fungus. (uncmedicalcenter.org)
- The solubilities of miconazole nitrate powder are 0.03% in water, 0.76% in ethanol and up to 4% in acetic acid. (wikipedia.org)
- Is there anywhere to get the Miconazole Nitrate powder? (hairlosstalk.com)
- Is it okay to use butenafine hydrochloride cream (1%) along with miconazole nitrate powder spray (2%) at the sametime for fungal treatment on groin? (healthtap.com)
- Ingredients Active Ingredients: Miconazole Nitrate (1200 mg) (in Vaginal Insert), Miconazole Nitrate 2% (External Cream). (heb.com)
- Phytosphingosine-1-phosphate is a signaling molecule involved in miconazole resistance in sessile Candida albicans cells. (nih.gov)
- Previous research has shown that 1% to 10% of sessile Candida albicans cells survive treatment with high doses of miconazole (a fungicidal imidazole). (nih.gov)
- Efficacy analyses included 254 patients with culture-confirmed Candida (119 butoconazole and 135 miconazole users). (gsajournals.org)
Active ingredient miconazole1
- It contains the active ingredient Miconazole which destroys fungi and bacteria that cause infection. (chemistdirect.co.uk)
Containing miconazole nitrate1
- The aim of this research was to develop and validate a discriminatory IVRT system using vertical diffusion cells (VDCs) to assess generic topical products containing miconazole nitrate (MCZ). (mdpi.com)
- Miconazole is also used to treat vaginal fungal infections. (medicinenet.com)
Form of miconazole1
- Most reports (128,88%) concerned the oral gel form of miconazole. (www.gov.uk)
Amounts of miconazole2
Activity of miconazole1
- Imipramine also showed activity against intracellular amastigotes and enhanced the activity of miconazole, without apparent toxicity to the host cells. (biomedcentral.com)
Delivery of miconazole2
- MN-SLN was more efficient in the treatment of candidiasis with enhanced oral bioavailability and could be a promising carrier for the oral delivery of miconazole. (dovepress.com)
- This study was designed to investigate an intravaginal drug delivery system based on biocompatible phytolipids [Softisan ® 154 (SF) (hydrogenated palm oil) and super-refined sunseed oil (SO)] and polyethylene glycol (PEG)-4000 for improved physicochemical performance and safe delivery of miconazole nitrate (MN). (ajol.info)
Warfarin and miconazole2
Interact with miconazole3
- Many other medications may also interact with miconazole, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. (medlineplus.gov)
- What other drugs could interact with Miconazole? (internationaldrugmart.com)
- Grapefruit and grapefruit juice may interact with miconazole and lead to potentially dangerous effects. (rxwiki.com)
Known whether miconazole2
Broad spectrum antifungal1
- Miconazole is a broad spectrum antifungal agent. (bmj.com)
Fluconazole and Miconazole1
- glabrata showed the lowest susceptibility to fluconazole and miconazole , and the highest to ketoconazole. (thefreedictionary.com)
Concentrations of miconazole1
- For assays of the combined treatment in amastigotes, the concentration of imipramine was fixed at 12.5 μM and various concentrations of miconazole were used up to 16 μM. (biomedcentral.com)
- Miconazole is in a class of antifungal medications called imidazoles. (medlineplus.gov)
- Miconazole buccal is in a class of medications called imidazoles. (medlineplus.gov)
- Ketoconazole cream and miconazole are antifungal medications prescribed to treat fungal infections such as athlete's foot and ringworm . (medicinenet.com)
- Miconazole is in the imidazole family of medications. (wikipedia.org)
- People who are not using these medications or experiencing irritation can experiment with miconazole at their discretion. (wisegeek.com)
- Some questions have been raised about the use of miconazole at the same time as other medications, particularly metronidazole, which is an antibiotic. (mothertobaby.org)
- In the UK, miconazole may be used to treat neonatal oral thrush, while the alternative nystatin is only licensed for patients over the age of one month, but drug interactions are possible. (wikipedia.org)
- These interactions are not relevant for miconazole that is applied to the skin. (wikipedia.org)
- Mechanisms of stereoselective interactions between miconazole and racemic warfarin in human subjects. (bmj.com)
- In view of reports of serious bleeding events in patients taking miconazole and warfarin, we are considering further measures to minimise the risk of potentially serious interactions between miconazole and warfarin. (www.gov.uk)
- The potential for drug interactions between miconazole and warfarin is well established 1 2 3 . (www.gov.uk)
- Up to 13 April 2016, we have received 146 Yellow Cards that report possible drug interactions between miconazole and warfarin. (www.gov.uk)
- Suspected drug interactions between miconazole and warfarin should be reported to us on a Yellow Card . (www.gov.uk)
- Miconazole is mainly used externally for the treatment of ringworm including jock itch and athlete's foot. (wikipedia.org)
- 22 that the Food and Drug Administration has approved a supplemental New Drug Application to expand the use of Miconazole cream 1% (Luzu) to include the following indications: the topical treatment of patients aged 12 years and older with athlete's foot (interdigital tinea pedis) and jock itch (tinea cruris) and of patients aged 2 years and older with ringworm (tinea corporis) caused by the organisms Trichophyton rubrum and Epidermophyton floccosum. (thefreedictionary.com)
- In a wellcontrolled, doubleblind, randomized study, 30 patients with cutaneous candidiasis were treated with a 2% miconazole nitrate lotion or its placebo control. (gsajournals.org)
- Myra A. Lappin, Doris C. Brooker, Carol A. Francisco, and Joan Dorfman, "Effect of Butoconazole Nitrate 2% Vaginal Cream and Miconazole Nitrate 2% Vaginal Cream Treatments in Patients with Vulvovaginal Candidiasis," Infectious Diseases in Obstetrics and Gynecology , vol. 4, no. 6, pp. 323-328, 1996. (hindawi.com)
- PRX ), today announced that the U.S. Food and Drug Administration (FDA) has accepted the new drug application (NDA) for miconazole Lauriad((R)) mucoadhesive buccal tablets (MBT) to treat oropharyngeal candidiasis (OPC). (bio-medicine.org)
- Treatment of oropharyngeal candidiasis in immunocompetent infants: a randomised multicenter study of miconazole gel vs. nystatin suspension. (breastfeedingnetwork.org.uk)
- Miconazole works by clearing fungal infection thanks to antifungal agents when applied directly to the skin. (allivet.com)
- Another theory is that miconazole might be mistakenly credited with increasing hair growth by eliminating tinea capitis. (wisegeek.com)
- I finished equate miconazole 7 about 3 days ago, the box says no sex while using medicine, but I'm done now, is it safe to masterbait? (healthtap.com)
- Buccal miconazole comes as a tablet to apply to the upper gum of the mouth. (medlineplus.gov)
- Use buccal miconazole at around the same time every day. (medlineplus.gov)
- If you become pregnant while using buccal miconazole, call your doctor. (medlineplus.gov)
- Appropriate studies have not been performed on the relationship of age to the effects of buccal miconazole in children younger than 16 years of age. (mayoclinic.org)
- No information is available on the relationship of age to the effects of buccal miconazole in the elderly. (mayoclinic.org)
- Prescribing information for products that contain miconazole warns that because miconazole inhibits CYP2C9, caution should be exercised for patients on oral anticoagulants such as warfarin, and the anticoagulant effect monitored (warfarin dose reduction may be needed). (www.gov.uk)
Oral gel and warfarin4
- If concomitant use of miconazole oral gel and warfarin is necessary, the patient's INR should be carefully monitored. (medsafe.govt.nz)
- CARM has received 16 reports of adverse effects in association with miconazole oral gel and warfarin. (medsafe.govt.nz)
- If the concomitant use of miconazole oral gel and warfarin is necessary, the patient's INR should be carefully monitored and the dose of warfarin adjusted as required. (medsafe.govt.nz)
- This review follows a coroner's report of a death, which may have been partly due to the coadministration of miconazole oral gel and warfarin. (www.gov.uk)
Younger than 16 years1
- Miconazole buccal is not approved for use by anyone younger than 16 years old. (cigna.com)
- This study is designed to investigate the safety and efficacy of intra-arterial miconazole in inhibiting BK-mediated forearm vasodilation in normal volunteers. (clinicaltrials.gov)
- Although the utility of azole therapy has been demonstrated in several observations, little is known about the efficacy of one of azoles, miconazole (MCZ). (scirp.org)
- If our impression is correct, then these groups differ in the interpretation of the meager data on the efficacy of miconazole in treating these diseases. (annals.org)
- In this context, we investigated whether imipramine alters the biosynthesis of sterols in L. amazonensis and evaluated the efficacy of imipramine alone and in combination with miconazole, a classical inhibitor of another step in this pathway. (biomedcentral.com)
- Miconazole may cause side effects. (medlineplus.gov)
- Side effects of ketoconazole and miconazole that are similar include skin rash and itching . (medicinenet.com)
- What are the side effects of ketoconazole and miconazole? (medicinenet.com)
- Comments & ratings on the side effects, benefits, and effectiveness of miconazole nitrate topical . (webmd.com)
- Though generally considered a safe and effective treatment, burning, itching, irritation, and other mild side effects sometimes accompany miconazole use. (fsu.edu)
- Also, recent evidence indicates that some miconazole-containing products react adversely with the blood thinning drug warfarin, leading to more serious side effects, including nosebleeds, bleeding of the gums, and bruising. (fsu.edu)
- The miconazole lotion formula was well tolerated by all patients and no side effects were noted. (gsajournals.org)
- Miconazole can cause side effects such as irritation and burning. (internationaldrugmart.com)
- Are there any adverse side effects to miconazole? (healthtap.com)
- What are the side effects of Miconosol Lotion 1% (Miconazole Nitrate), 60ml? (allivet.com)
Mucoadhesive buccal tablet1
- Miconazole MBT delivers the antifungal miconazole via a mucoadhesive buccal tablet that is designed to enable once-daily dosing of the active ingredient at the site of infection. (bio-medicine.org)