Murinae: A subfamily in the family MURIDAE, comprising the Old World MICE and RATS.Muridae: A family of the order Rodentia containing 250 genera including the two genera Mus (MICE) and Rattus (RATS), from which the laboratory inbred strains are developed. The fifteen subfamilies are SIGMODONTINAE (New World mice and rats), CRICETINAE, Spalacinae, Myospalacinae, Lophiomyinae, ARVICOLINAE, Platacanthomyinae, Nesomyinae, Otomyinae, Rhizomyinae, GERBILLINAE, Dendromurinae, Cricetomyinae, MURINAE (Old World mice and rats), and Hydromyinae.Phylogeny: The relationships of groups of organisms as reflected by their genetic makeup.Evolution, Molecular: The process of cumulative change at the level of DNA; RNA; and PROTEINS, over successive generations.Gammaherpesvirinae: A subfamily of HERPESVIRIDAE characterized by variable reproductive cycles. The genera include: LYMPHOCRYPTOVIRUS and RHADINOVIRUS.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Herpesviridae Infections: Virus diseases caused by the HERPESVIRIDAE.Herpesviridae: A family of enveloped, linear, double-stranded DNA viruses infecting a wide variety of animals. Subfamilies, based on biological characteristics, include: ALPHAHERPESVIRINAE; BETAHERPESVIRINAE; and GAMMAHERPESVIRINAE.BooksPublishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.Research Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.Research Support, Non-U.S. Gov'tResearch Support, U.S. GovernmentMolecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Research Support, American Recovery and Reinvestment ActResearch Support, N.I.H., ExtramuralCheirogaleidae: A family of the order PRIMATES, suborder Strepsirhini (PROSIMII), containing five genera. All inhabitants of Madagascar, the genera are: Allocebus, Cheirogaleus (dwarf lemurs), Microcebus (mouse lemurs), Mirza, and Phaner.Lemur: A genus of the family Lemuridae consisting of five species: L. catta (ring-tailed lemur), L. fulvus, L. macaco (acoumba or black lemur), L. mongoz (mongoose lemur), and L. variegatus (white lemur). Most members of this genus occur in forested areas on Madagascar and the Comoro Islands.Madagascar: One of the Indian Ocean Islands off the southeast coast of Africa. Its capital is Antananarivo. It was formerly called the Malagasy Republic. Discovered by the Portuguese in 1500, its history has been tied predominantly to the French, becoming a French protectorate in 1882, a French colony in 1896, and a territory within the French union in 1946. The Malagasy Republic was established in the French Community in 1958 but it achieved independence in 1960. Its name was changed to Madagascar in 1975. (From Webster's New Geographical Dictionary, 1988, p714)Lemuridae: A family of the order PRIMATES, suborder Strepsirhini (PROSIMII), containing four genera which inhabit Madagascar and the Comoro Island. Most of the lemurs prefer wooded areas. The four genera are Hapalemur, LEMUR, Lepilemur, and Varecia.ShrewsLongevity: The normal length of time of an organism's life.Hepatic Stellate Cells: Perisinusoidal cells of the liver, located in the space of Disse between HEPATOCYTES and sinusoidal endothelial cells.Thymidine Kinase: An enzyme that catalyzes the conversion of ATP and thymidine to ADP and thymidine 5'-phosphate. Deoxyuridine can also act as an acceptor and dGTP as a donor. (From Enzyme Nomenclature, 1992) EC 126.96.36.199.Desmin: An intermediate filament protein found predominantly in smooth, skeletal, and cardiac muscle cells. Localized at the Z line. MW 50,000 to 55,000 is species dependent.Ganciclovir: An ACYCLOVIR analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections.Simplexvirus: A genus of the family HERPESVIRIDAE, subfamily ALPHAHERPESVIRINAE, consisting of herpes simplex-like viruses. The type species is HERPESVIRUS 1, HUMAN.Propanols: Isomeric forms and derivatives of PROPANOL (C3H7OH).Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Biglycan: A small leucine-rich proteoglycan found in a variety of tissues including CAPILLARY ENDOTHELIUM; SKELETAL MUSCLE; CARTILAGE; BONE; and TENDONS. The protein contains two glycosaminoglycan chains and is similar in structure to DECORIN.Thrombin: An enzyme formed from PROTHROMBIN that converts FIBRINOGEN to FIBRIN.Heparin Cofactor II: A sulfated plasma protein with a MW of approximately 66kDa that resembles ANTITHROMBIN III. The protein is an inhibitor of thrombin in plasma and is activated by dermatan sulfate or heparin. It is a member of the serpin superfamily.Decorin: A small leucine-rich proteoglycan that interacts with FIBRILLAR COLLAGENS and modifies the EXTRACELLULAR MATRIX structure of CONNECTIVE TISSUE. Decorin has also been shown to play additional roles in the regulation of cellular responses to GROWTH FACTORS. The protein contains a single glycosaminoglycan chain and is similar in structure to BIGLYCAN.Fibrinopeptide A: Two small peptide chains removed from the N-terminal segment of the alpha chains of fibrinogen by the action of thrombin during the blood coagulation process. Each peptide chain contains 18 amino acid residues. In vivo, fibrinopeptide A is used as a marker to determine the rate of conversion of fibrinogen to fibrin by thrombin.Atherosclerosis: A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA.Extracellular Matrix Proteins: Macromolecular organic compounds that contain carbon, hydrogen, oxygen, nitrogen, and usually, sulfur. These macromolecules (proteins) form an intricate meshwork in which cells are embedded to construct tissues. Variations in the relative types of macromolecules and their organization determine the type of extracellular matrix, each adapted to the functional requirements of the tissue. The two main classes of macromolecules that form the extracellular matrix are: glycosaminoglycans, usually linked to proteins (proteoglycans), and fibrous proteins (e.g., COLLAGEN; ELASTIN; FIBRONECTINS; and LAMININ).Mice, Inbred NZBLupus Erythematosus, Systemic: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.Rheumatic Diseases: Disorders of connective tissue, especially the joints and related structures, characterized by inflammation, degeneration, or metabolic derangement.Antibodies, Antinuclear: Autoantibodies directed against various nuclear antigens including DNA, RNA, histones, acidic nuclear proteins, or complexes of these molecular elements. Antinuclear antibodies are found in systemic autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, scleroderma, polymyositis, and mixed connective tissue disease.Lupus Nephritis: Glomerulonephritis associated with autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Lupus nephritis is histologically classified into 6 classes: class I - normal glomeruli, class II - pure mesangial alterations, class III - focal segmental glomerulonephritis, class IV - diffuse glomerulonephritis, class V - diffuse membranous glomerulonephritis, and class VI - advanced sclerosing glomerulonephritis (The World Health Organization classification 1982).Autoantibodies: Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them.Autoimmune Diseases: Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides.Leukemia, Experimental: Leukemia induced experimentally in animals by exposure to leukemogenic agents, such as VIRUSES; RADIATION; or by TRANSPLANTATION of leukemic tissues.Leukemia Virus, Murine: Species of GAMMARETROVIRUS, containing many well-defined strains, producing leukemia in mice. Disease is commonly induced by injecting filtrates of propagable tumors into newborn mice.Propionibacterium acnes: A bacteria isolated from normal skin, intestinal contents, wounds, blood, pus, and soft tissue abscesses. It is a common contaminant of clinical specimens, presumably from the skin of patients or attendants.Corynebacterium: A genus of asporogenous bacteria that is widely distributed in nature. Its organisms appear as straight to slightly curved rods and are known to be human and animal parasites and pathogens.Immunization: Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).Moloney murine leukemia virus: A strain of Murine leukemia virus (LEUKEMIA VIRUS, MURINE) arising during the propagation of S37 mouse sarcoma, and causing lymphoid leukemia in mice. It also infects rats and newborn hamsters. It is apparently transmitted to embryos in utero and to newborns through mother's milk.Gammaretrovirus: A genus of RETROVIRIDAE comprising endogenous sequences in mammals, related RETICULOENDOTHELIOSIS VIRUSES, AVIAN, and a reptilian virus. Many species contain oncogenes and cause leukemias and sarcomas.
Family: Muridae (mice, rats, etc.) Subfamily: Murinae Genus: Mus House mouse Mus musculus LC. Very early introduction. Genus: ... arvalis Water vole Arvicola terrestris Harvest mouse Micromys minutus Yellow-necked mouse A. flavicollis Edible dormouse Glis ... The shrews and solenodons closely resemble mice while the moles are stout-bodied burrowers. Family: Soricidae (shrews) ... Apodemus Wood mouse Apodemus sylvaticus LC. Probably introduced by early man. Genus: Rattus Brown rat Rattus norvegicus - not ...
Murine ctns has also been used. Cystinosis Lysosomal storage disorders Lysosomal Cystine Transporter Family GRCh38: Ensembl ... "Mouse PubMed Reference:". Town M, Jean G, Cherqui S, Attard M, Forestier L, Whitmore SA, Callen DF, Gribouval O, Broyer M, ... Cherqui S, Kalatzis V, Forestier L, Poras I, Antignac C (2003). "Identification and characterisation of the murine homologue of ... "Intralysosomal cystine accumulation in mice lacking cystinosin, the protein defective in cystinosis". Molecular and Cellular ...
murinum - mouse buckwheat Eriogonum nudum var. nudum Eriogonum nudum var. oblongifolium - oblong-leaved buckwheat Eriogonum ...
frerei LC Family: Muridae (mice, rats, voles, gerbils, hamsters, etc.) Subfamily: Murinae Genus: Cricetomys Gambian pouched rat ... cosensi LC Genus: Mus House mouse Mus musculus ssp. gentilis LC Brown rat Rattus norvegicus LC Black rat Rattus rattus LC "The ... suahelae LC Genus: Suncus Asian house shrew Suncus murinus LC Often called elephant shrews or jumping shrews are native to ...
"Mouse virus doesn't cause chronic fatigue: reports". Reuters. "Murine viruses not linked to human infection". MD News. June 1, ... "Murine viruses not linked to human infection". Doctors Lounge. June 1, 2011. Knox, K; Carrigan, D; Simmons, G; Teque, F; Zhou, ... Jason Bardi (May 31, 2011). "Mouse virus erroneously linked to chronic fatigue syndrome". University of California at San ... Jul 2011). "No evidence of murine-like gammaretroviruses in CFS patients previously identified as XMRV-infected". Science. 333 ...
"Myopathic changes in murine skeletal muscle lacking synemin". Am J Physiol Cell Physiol. 308 (6): C448-62. doi:10.1152/ajpcell. ... "Mouse PubMed Reference:". "Entrez Gene: Synemin, intermediate filament protein". Garcia-Pelagio KP, Muriel J, O'Neill A, ...
These mice show a reduced beta cell mass as well as developmental defects. This as well as other observations, showing that ... Byrd, N (2002). "Hedgehog is required for murine yolk sac angiogenesis". Development. 129 (2): 361-72. PMID 11807029. Banaei- ... Islet resident macrophages depend on the expression of colony stimulating factor (CSF1). Knockout mice for the CSF-1 gene cause ... Hume, DA (1984). "The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80: ...
Mouse mammary tumour virus Genus Gammaretrovirus; type species: Murine leukemia virus; others include Feline leukemia virus ... Retroviruses that cause tumor growth include Rous sarcoma virus and Mouse mammary tumor virus. Cancer can be triggered by proto ... Retroviral mutations can be developed to make transgenic mouse models to study various cancers and their metastatic models. ...
"Mouse PubMed Reference:". Kohama T, Olivera A, Edsall L, Nagiec MM, Dickson R, Spiegel S (Sep 1998). "Molecular cloning and ... functional characterization of murine sphingosine kinase". The Journal of Biological Chemistry. 273 (37): 23722-8. doi:10.1074/ ...
It is highly homologous to the murine Npm3 gene. Based on the structural similarity of the human NPM3 gene product to ... 2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci ... "Mouse PubMed Reference:". Shackleford GM, Ganguly A, MacArthur CA (Jul 2003). "Cloning, expression and nuclear localization of ...
Sp8 deletion in mice resulted in severe exencephaly. Sp8 is a zinc-finger transcription factor. The structural difference ... "mBtd is required to maintain signaling during murine limb development". Genes & Development. 17 (21): 2630-5. doi:10.1101/gad. ... "Mouse PubMed Reference:". Treichel D, Schöck F, Jäckle H, Gruss P, Mansouri A (November 2003). " ... "An atlas of combinatorial transcriptional regulation in mouse and man". Cell. 140 (5): 744-52. doi:10.1016/j.cell.2010.01.044. ...
Knockout mice which genetically lack IL-7 receptor exhibit thymic atrophy, arrest of T-cell development at the double positive ... 1990). "Characterization of the human and murine IL-7 genes". J. Immunol. 144 (9): 3592-601. PMID 2329282. Heufler C, Topar G, ... Administration of IL-7 to mice results in an increase in recent thymic emigrants, increases in B and T cells, and increased ... September 1993). "Interleukin 7 is produced by murine and human keratinocytes". J. Exp. Med. 178 (3): 1109-14. doi:10.1084/jem. ...
2000). "CNS myelin and sertoli cell tight junction strands are absent in Osp/claudin-11 null mice". Cell. 99 (6): 649-59. doi: ... "Chromosomal localization of murine and human oligodendrocyte-specific protein genes". Genomics. 34 (2): 255-7. doi:10.1006/geno ... 2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci ... 2001). "Protein-Protein Interaction Panel Using Mouse Full-Length cDNAs". Genome Res. 11 (10): 1758-65. doi:10.1101/gr.180101. ...
2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci ... Differences in gene structure and promoter function from murine species". J. Biol. Chem. 263 (25): 12538-42. PMID 2457586. ... 2003). "Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios". Science. 302 (5652): 1960-3. doi:10.1126 ... "Mouse PubMed Reference:". Wondisford FE, Radovick S, Moates JM, Usala SJ, Weintraub BD (September 1988). "Isolation and ...
"Mouse PubMed Reference:". Hinderlich S, Berger M, Schwarzkopf M, Effertz K, Reutter W (Jun 2000). "Molecular cloning and ... characterization of murine and human N-acetylglucosamine kinase". European Journal of Biochemistry / FEBS. 267 (11): 3301-8. ...
"Entrez Gene: DEF6 differentially expressed in FDCP 6 homolog (mouse)". Oka T, Ihara S, Fukui Y (Jan 2007). "Cooperation of DEF6 ... "Adaptor protein SLAT modulates Fcgamma receptor-mediated phagocytosis in murine macrophages". The Journal of Biological ... "Mouse PubMed Reference:". Mehta H, Glogauer M, Bécart S, Altman A, Coggeshall KM (May 2009). " ...
"Mouse PubMed Reference:". "Entrez Gene: ARAF V-raf murine sarcoma 3611 viral oncogene homolog". Mark GE, Seeley TW, Shows TB, ...
Staal SP, Hartley JW, Rowe WP (July 1977). "Isolation of transforming murine leukemia viruses from mice with a high incidence ... "Mouse PubMed Reference:". "Entrez Gene: AKT1 v-akt murine thymoma viral oncogene homolog 1". Lindhurst MJ, Sapp JC, Teer JK, ... and thus came the Ak strain of mice. Further inbreeding was undertaken with Ak mice at the Rockefeller Institute in 1936, ... leading to the designation of the AKR mouse strain. In 1977, a transforming retrovirus was isolated from the AKR mouse. This ...
Kirsten WH, Schauf V, McCoy J (1970). "Properties of a murine sarcoma virus". Bibl Haematol (36): 246-9. PMID 5538357. Cooper ... Harvey JJ (December 1964). "An unidentified virus which causes the rapid production of tumours in mice". Nature. 204 (4963): ... In glioblastoma mouse models SHP2 levels were heightened in cancerous brain cells. Inhibiting SHP2 in turn inhibited Ras ... "Human genome contains four genes homologous to transforming genes of Harvey and Kirsten murine sarcoma viruses". Proc. Natl. ...
In mice, this gene was identified as a breakpoint site in chromosome 6;15 translocations. These translocations are associated ... translocations in murine plasmacytomas involve a chromosome 15 locus at least 72 kb from the c-myc oncogene". EMBO J. 4 (3): ... "Human PubMed Reference:". "Entrez Gene: PVT1 Pvt1 oncogene homolog, MYC activator (mouse)". Cory S, Graham M, Webb E, Corcoran ... 2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci ...
"Mouse PubMed Reference:". Prakash S, Robbins PW, Wyler DJ (Apr 1995). "Cloning and analysis of murine cDNA that encodes a ... 2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci ...
In vivo testing of mice that developed murine colon carcinoma tumour cells. They were injected with the solution of AuNPs that ... Results of their in vivo nanoshell therapy of mice revealed penetration of the tumor ~5mm.The metal particles were tuned to ... Gold nanoparticle uptake in cells is often carried out by examining the organs of injected mice post-mortem. This technique ... Even without complete clearance from the system, the nanoshells did not cause any physiological complications in the mice. Su ...
Pires-daSilva A, Nayernia K, Engel W, Torres M, Stoykova A, Chowdhury K, Gruss P (May 2001). "Mice deficient for spermatid ... a murine RNA-binding protein that is localized to cytoplasmic microtubules". The Journal of Cell Biology. 129 (4): 1023-32. doi ... "Mouse PubMed Reference:". "Entrez Gene: STRBP spermatid perinuclear RNA binding protein". Schumacher JM, Lee K, Edelhoff S, ... ribonucleic acid-binding protein binds microtubules in vitro and associates with abnormal manchettes in vivo in mice". Biology ...
1991). "Biochemistry and function of pteridine synthesis in human and murine macrophages". Pathobiology. 59 (4): 276-9. doi: ... "Mouse PubMed Reference:". "Entrez Gene: PTS 6-pyruvoyltetrahydropterin synthase". Werner ER, Werner-Felmayer G, Fuchs D, et al ...
The resulting murine antibodies are harvested and used to vaccinate other mice. The resulting antibodies in the second set of ... To the murine immune system, the TAA antibodies are antigens and cause an immunogenic reaction producing murine antibodies that ... The murine immune system essentially "amplifies" a small mass of TAA antibodies into a much larger mass used to vaccinate ... mice have a three-dimensional binding site that mimics the original antibodies that bind tumor-associated antigens. These ...
Impaired CD8 T cell memory and CD4 T cell primary responses in IL-7R alpha mutant mice. The Journal of Experimental Medicine. ... Invariant and noninvariant natural killer T cells exert opposite regulatory functions on the immune response during murine ...
2010), Non-shivering thermogenesis activation and maintenance in the aging gray mouse lemur (Microcebus murinus) (PubMed) ... Microcebus murinus. Common name. Gray mouse lemur. Synonyms. Chirogaleus gliroides, Galago madagascarensis, Prosimia minima, ... and grey lesser mouse lemur (Microcebus murinus): comparison to iron localization (PubMed) ... and gray lesser mouse lemur (Microcebus murinus) (PubMed) ... the gray mouse lemur (Microcebus murinus) (PubMed) ...
1989) described a line of transgenic mice that carry an activated pim-1 proto-oncogene transgene (Eµ pim-1). They also reported ... In these experiments, neonatal Eµ pim-1 transgenic mice were infected intraperitoneally with ΔMo + SV M-MuLV. Marked ... When this virus is injected into neonatal NIH Swiss mice, pre-B and B-lymphoblastic lymphomas develop with a latency of 17 ... that Eµ pim-1 transgenic mice show greatly accelerated lymphoma development when infected with wild-type M-MuLV at birth. ...
Claires mouse lemur; M. mittermeieri: Mittermeiers mouse lemur; M. murinus: grey mouse lemur, lesser mouse lemur; microcèbe ... Bongolava mouse lemur; M. danfossi: Danfoss mouse lemur; M. griseorufus: rufous-grey mouse lemur, red-and-grey mouse lemur; ... Other names: M. berthae: Madame Berthes mouse lemur, pygmy mouse lemur, Berthes mouse lemur; microcèbe de Berthe (French); ... murinus and M. berthae in western Madagascar and M. murinus and M. griseorufus in southern Madagascar and M. murinus and M. ...
All shrews are small, most no larger than a mouse. The largest is the Asian house shrew (Suncus murinus), which is about 15 cm ... Although its external appearance is generally that of a long-nosed mouse, a shrew is not a rodent, as mice are. In fact it is ... Seasonal changes in weight and reproductive activity of Suncus murinus in West Bengal, India. Journal of Mammalogy 47 (1): 73- ... Shrews are small mammals which look rather like mice. They were classified in the old Insectivora, but that is no longer used. ...
All shrews are small, most no more than mouse-size. The Etruscan shrew, Suncus etruscus, has an adult body mass between 1.6 ... One of the largest shrews is the Indian musk shrew, Suncus murinus, with body weights ranging from 33.2 grams to 147.3 grams ( ... In zoology, shrew is the common name for small, mouse-like insectivorous mammals comprising the family Soricidae, characterized ... Genetic differentiation and zoogeography of the Asian house shrew Suncus murinus (Mammalia: Soricidae). Biological Journal of ...
Pathogenesis of acute and persistent murine herpesvirus infection in mice.. Rajcáni J, Blaskovic D, Svobodová J, Ciampor F, ... Outbred laboratory mice were inoculated at the age of 5, 10 and 21 days by oral and/or intranasal routes with 2 different (a ... and kidneys developed in the 5-day-old as well as in a part of the 10-day-old mice. Virus antigen was found by ... lethal and a nonlethal) doses of the murine herpesvirus isolate 68 (MHV-68). Severe exudative pneumonia with haematogenous ...
Crystal structure of mouse coronavirus receptor-binding domain complexed with its murine receptor.. Peng G1, Sun D, Rajashankar ... Crystal structure of mouse coronavirus receptor-binding domain complexed with its murine receptor ... Crystal structure of mouse coronavirus receptor-binding domain complexed with its murine receptor ... Crystal structure of mouse coronavirus receptor-binding domain complexed with its murine receptor ...
Microcell-mediated transfer of murine chromosomes into mouse, Chinese hamster, and human somatic cells. R E Fournier and F H ... Microcell-mediated transfer of murine chromosomes into mouse, Chinese hamster, and human somatic cells ... Microcell-mediated transfer of murine chromosomes into mouse, Chinese hamster, and human somatic cells ... Microcell-mediated transfer of murine chromosomes into mouse, Chinese hamster, and human somatic cells ...
Inbred mice chronically infected with the virus develop a lymphoproliferative disease (LPD) similar to that seen in patient … ... Murine gammaherpesvirus is a natural pathogen of wild rodents. In the laboratory it establishes an infection of epithelial ... Lymphoproliferative disease in mice infected with murine gammaherpesvirus 68 Am J Pathol. 1994 Oct;145(4):818-26. ... These observations suggest that murine gammaherpesvirus-infected mice may be an important model to study the pathogenesis of ...
Murine) LRP6 ELISA kit for many sample types. ... Alternative Mouse (Murine) LRP6 Products Relevance Score. ABIN ... Mouse (Murine) Alternatives Kits with alternative reactivity to: Human. (13), Mouse (Murine). (5), Cow (Bovine). (1), Dog ( ... Mouse (Murine). Rat (Rattus). Rabbit. Guinea Pig. Pig (Porcine). Dog (Canine). Cow (Bovine). Monkey. Sheep (Ovine). ... For the quantitative determination of mouse LRP6 concentrations in serum, plasma,cell culture supernates and tissue homogenate ...
Murine) - Sample Type: Cell Culture Supernatant, Cell Samples. , Order Interleukin 23 (IL23) ELISA Kit (ABIN6730362). ... This ELISA antibody pair recognizes Mouse IL23. Characteristics *Strip plates and additional reagents allow for use in multiple ...
... Christian Albrecht May ... Y. Lee, S. Kameya, G. A. Cox et al., "Ocular abnormalities in Large(myd) and Large(vls) mice, spontaneous models for muscle, ... J. Schymeinsky, S. Nedbal, N. Miosge et al., "Gene structure and functional analysis of the mouse nidogen-2 gene: nidogen-2 is ... M. Murshed, N. Smyth, N. Miosge et al., "The absence of nidogen 1 does not affect murine basement membrane formation," ...
This biochemical defect causes a murine lysosomal storage disease that has many interesting similarities to human ... We have characterized a new mutant mouse that has virtually no beta-glucuronidase activity. ... Murine mucopolysaccharidosis type VII. Characterization of a mouse with beta-glucuronidase deficiency J Clin Invest. 1989 Apr; ... Analysis of this mutant mouse may offer valuable information on the pathogenesis of human MPS VII and provide a useful system ...
These mice develop the histological compendium of putative precursor lesions, which are designated as murine PanIN or "mPanIN" ... For example, in Pdx1-Cre; LSL-KrasG12D mice, only 7% of mice developed PDAC with latency over 1 year, although 100% of the ... KrasG12Vgeo mice and Ela-CreERT2Tg/+ (or Mist1CreERT2/+); LSL- KrasG12D mice. For example, comparisons between various Ras ... Recent genetically engineered mouse models of PDAC demonstrate a comparable morphologic spectrum of murine PanIN (mPanIN) ...
EGFL6 Mouse Recombinant produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 273 amino acids and ... EGFL6 Mouse Recombinant produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 273 amino acids ( ... Within shared regions, human EGFL6 shares 75% and 78% amino acid sequence identity with the mouse and rat orthologs, ...
BLMH Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 478 amino acids and having ... BLMH Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 478 amino acids (1-455 aa ...
A novel murine model to deplete hepatic stellate cells uncovers their role in amplifying liver damage in mice†‡. Authors. *. ... In TG mice treated with CCl4+AA+GCV, there was a significant decrease in GFAP and desmin-positive cells, compared to WT mice (∼ ... Transgenic (Tg) mice expressing the herpes simplex virus thymidine kinase gene (HSV-Tk) driven by the mouse GFAP promoter were ... In primary HSCs isolated from both untreated wild-type (WT) and Tg mice, GCV induced cell death in ∼50% of HSCs from Tg, but ...
B: Mean insulitis score of 10- to 15-week-old mice. C: Mean insulitis score of mice after 30 weeks of age, with diabetic mice ... female mice. F: Mean insulitis score at end of incidence showing 9-15 mice per group, with diabetic mice receiving a score of 4 ... L and M: NOD, NOD.β2m−/−-A2, and NOD-cMHCI−/−-A2 mice were injected on day 0 with mouse IgG1 (1B7.11) (L) and humanized IgG1 ( ... Improved Murine MHC-Deficient HLA Transgenic NOD Mouse Models for Type 1 Diabetes Therapy Development. ...
Transgenic Mouse Mammary Gland Milk Sample Founder Mouse Slot Blot Analysis This is a preview of subscription content, log in ... Expression of Biologically Active Human Interferon Gamma in the Milk of Transgenic Mice Under the Control of the Murine Whey ... Bagis H, Papuccuoglu S (1997) Studies on the production of transgenic mice. Turk J Vet Anim Sci 21:287-292Google Scholar ... Hogan B, Beddigton R, Costantini F, Lacy E (1994) Manipulating the mouse embryo: a laboratory manual, 2nd edn. Cold Spring ...
A Comparative Analysis of Flask Culture Method and Mouse CD11c Positive Selection Kit Method. Rahul Ashok Gosavi,1 Sukeshani ... Rahul Ashok Gosavi, Sukeshani Salwe, Sandeepan Mukherjee, et al., "Optimization of Ex Vivo Murine Bone Marrow Derived Immature ... Optimization of Ex Vivo Murine Bone Marrow Derived Immature Dendritic Cells: ... Dendritic Cells: A Comparative Analysis of Flask Culture Method and Mouse CD11c Positive Selection Kit Method," Bone Marrow ...
The liver damage, in particular, occurred earlier and was more severe in PD-1-deficient mice than in their wild type (WT) ... Here, we report that MHV-3 infection of program death-1 (PD-1)-deficient mice results in tissue damage throughout multiple ... determined that MHV-3 infection was associated with high levels of IFN-γ and TNF-α in the damaged organs of PD-1-deficient mice ... induced by the murine hepatitis virus strain-3 (MHV-3) is severe hepatocellular necrosis, which is mediated by the fibrinogen- ...
Anti-coagulated murine blood served as the source for platelets. Platelets were separated from other elements of the whole ... Here we provide details of the methods we have used for platelet isolation from mice and their staining for further microscopy ... These methods have facilitated study of the interactions between platelets and tumor cells in tissue culture and in murine ... we have adapted methods used in coagulation research for the isolation of platelets and their reintroduction into mice. ...
This TLR agonist kit is designed to study the stimulation of the murine Toll-Like Receptors from TLR1 to TLR9. This kit ... Mouse TLR1-9 Agonist kit. Mouse TLR1-9 Agonist kit (9 ligands). Unit size. Cat. code. Docs. Qty. Price. ... 9 ligands for murine TLR1 to TLR9. This Toll-like Receptor (TLR) agonist kit represents a convenient and economical tool to ... LACC1 Regulates TNF and IL-17 in Mouse Models of Arthritis and Inflammation.. Skon-Hegg C. et al. ...
... and parasitemia in all mice, whether delayed by immune serum or not, ultimately progressed to death. The protective capacity of ... mice was investigated using an immune serum prepared from mice which survived a lethal challenge of erythrocytic stage P. ... Host Defenses in Murine Malaria: Humoral Immunity to Plasmodium berghei in Mice * * James R. Murphy, Pamela S. Logie† ... mice was investigated using an immune serum prepared from mice which survived a lethal challenge of erythrocytic stage P. ...
MoloneyRodentsSuncusVirusMuLVRodentPathogenesisStrainGammaherpesvirusFlow cytometryStrainsDendritic CellsMacrophage inflammLymphocytesEmbryonic stemCoronavirusGenePhenotypeResistance to murineSecretion from murineAcuteRecombinantTumorIsolateSystemicGeneticallyProteinViralMethodsBone marrowModelsSpleenAntibodyCytokineGeneticProinflammatoryReceptorTransplantationMolecularHumansLifespanPulmonaryGenomesMCMVInflammatoryAntigenPeptideTregVirusRegulates
- We previously described an enhancer variant of Moloney murine leukaemia virus (M-MuLV), ΔMo + SV M-MuLV, in which the enhancers of MuLV have been deleted and replaced with the enhancers of the simian virus 40 (SV40). (microbiologyresearch.org)
- Moloney Murine Leukaemia Virus Reverse Transcriptase Kit, supplied by Thermo Fisher, used in various techniques. (bioz.com)
- Quantitative RT-PCR analysis First-strand cDNA was synthesized from DNase I-treated total RNA templates that were primed with oligo-dT using the Moloney-murine-leukaemia virus-reverse transcriptase kit from Invitrogen (San Diego, CA). .. Quantitative RT-PCR was performed using the Light Cycler system (Roche Diagnostics, Mannheim, Germany) or StepOnePlusTM Real-Time PCR System with FastStart SYBR green master mix (Applied Biosystems, Foster City, CA). (bioz.com)
- The largest is the Asian house shrew ( Suncus murinus ), which is about 15 cm long and weighs around 100 grams. (wikipedia.org)
- Seasonal changes in weight and reproductive activity of Suncus murinus in West Bengal, India. (wikipedia.org)
- One of the largest shrews is the Indian musk shrew, Suncus murinus, with body weights ranging from 33.2 grams to 147.3 grams (1.2 to 5.2 ounces) in males and somewhat smaller (23.5 to 80 grams) in females (Ruedi et al. (newworldencyclopedia.org)
- They also reported that Eµ pim -1 transgenic mice show greatly accelerated lymphoma development when infected with wild-type M-MuLV at birth. (microbiologyresearch.org)
- In these experiments, neonatal Eµ pim -1 transgenic mice were infected intraperitoneally with ΔMo + SV M-MuLV. (microbiologyresearch.org)
- These observations suggest that murine gammaherpesvirus-infected mice may be an important model to study the pathogenesis of LPD associated with other gammaherpesviruses, such as Epstein-Barr virus. (nih.gov)
- Analysis of this mutant mouse may offer valuable information on the pathogenesis of human MPS VII and provide a useful system in which to study bone marrow transplantation and gene transfer methods of therapy. (nih.gov)
- If MCMV-induced VEGF production by macrophages contributes directly to CNV pathogenesis, we hypothesized that ganciclovir (GCV) treatment of chronically infected mice will result in decreased expression of VEGF mRNA by splenic macrophages. (arvojournals.org)
- A decrease in Treg numbers or function has been directly associated with autoimmune pathogenesis in multiple diseases and their associated mouse models ( 1 , 2 ). (jimmunol.org)
- To investigate the molecular mechanism of disease pathogenesis, it is desirable to induce axial elongation in mice with an efficient and effective method in terms of genetic manipulation. (nature.com)
- Murine Gammaherpesvirus 68 Pathogenesis Is Independent of Caspase-1 and Caspase-11 in Mice and Impairs Interleukin-1β Production upon Extrinsic Stimulation in Culture. (gallusimmunotech.com)
- Unexpectedly, we found that murine gammaherpesvirus pathogenesis was not enhanced in mice lacking caspase-1, a critical inflammasome component. (gallusimmunotech.com)
- To determine the role of ZASC1 in retroviral replication and disease pathogenesis in vivo , we have now generated a ZASC1 −/− mouse strain. (biomedcentral.com)
- To address the potential role of ZASC1 in wild type (WT) Mo-MuLV replication and disease pathogenesis in vivo , we generated a ZASC1 conditional knockout mouse (Figure 1 A). ZASC1 contains 7 exons and the open reading frame is located in exons 4-7. (biomedcentral.com)
- In addition, it supports the notion that the NOS2-/-/NO pathway may contribute to the pathogenesis of murine chagasic cardiomyopathy. (ajtmh.org)
- 1997. Disruption of overlappin transcripts in the ROSA beta geo 26 gene trap strain leads to widespread expression of beta-galactosidase in mouse embryos and hematopoietic cells. (invivogen.com)
- Mouse hepatitis virus strain A59 (MHV-A59) is a murine coronavirus which is both hepatotropic and neurotropic. (asm.org)
- Mice with corneas predisposed to topographical changes (the SKC strain) were also examined, to establish the size and spacing of stromal collagen fibrils and the integrity of the annulus. (arvojournals.org)
- Their GWE variant profiles were compared to assess strain-specific sequence data integrity, and to analyze mouse strain relatedness across the ge-nome. (g3journal.org)
- In gnotobiotic mice colonized with the gut microbiota from old mice, this strain decreased their intestinal permeability and serum endotoxin load, consequently attenuating the inflammation induced by the old microbiota. (biomedcentral.com)
- Our study demonstrated that a strain of Lactobacillus murinus was promoted in CR mice and causatively contributed to the attenuation of ageing-associated inflammation. (biomedcentral.com)
- A specific strain of Lactobacillus murinus in the most abundant operational taxonomic unit (OTU) was isolated from the feces of CR mice and shown to be a key mediator of the anti-ageing and anti-inflammatory effects of CR in various experimental systems, including Caco-2 cells, Caenorhabditis elegans and old microbiota-colonized gnotobiotic mice. (biomedcentral.com)
- Verma S, Rawat M, Kumawat S, Qureshi S, Mohd G, Tiwari AK (2018) Protective role of Brucella abortus specific murine antibodies in inhibiting systemic proliferation of virulent strain 544 in mice and guinea pig, Veterinary World, 11(6): 794-799. (veterinaryworld.org)
- Mice of the AKR strain are characterized by a high incidence of spontaneous thymic lymphomas occurring after 6 mo of age. (psu.edu)
- disease, we infected mice with Trypanosoma cruzi (Brazil strain). (ajtmh.org)
- Murine gammaherpesvirus is a natural pathogen of wild rodents. (nih.gov)
- BALB/c mice (n=30), resistant to bleomycin, were primed with murine gammaherpesvirus 68 and then given intraperitoneal bleomycin. (ersjournals.com)
- Murine gammaherpesvirus γHV68 is genetically and biologically related to human gammaherpesviruses and herpesvirus saimiri and has been reported to be associated with lymphoproliferative disease in mice (N. P. Sunil-Chandra, J. Arno, J. Fazakerley, and A. A. Nash, Am. J. Pathol. (asm.org)
- We infected caspase-1-deficient mice with murine gammaherpesvirus 68 (MHV68) and observed no impact on acute replication in the lung or latency and reactivation from latency in the spleen. (gallusimmunotech.com)
- Taken together, murine gammaherpesvirus impairment of the inflammatory cytokine IL-1β in macrophages identifies one mechanism by which the virus may inhibit caspase-1-dependent immune responses in the infected animal. (gallusimmunotech.com)
- Representative flow cytometry histogram showing expression of H2-D and H2-K antibody staining on the surface of splenic B cells in comparison of 10-week-old female NOD, NOD.β2m −/− , and NOD-H2-D −/− mice. (diabetesjournals.org)
- Representative flow cytometry showing CD4 vs. CD8 of gated CD45.1 + thymocytes in comparison of 10-week-old female NOD and NOD-H2-D −/− mice. (diabetesjournals.org)
- Representative flow cytometry showing among splenocytes TCRβ vs. FSC-A (top) and TCRβ-gated CD4 vs. CD8 (bottom) from 10-week-old female mice. (diabetesjournals.org)
- Representative flow cytometry histogram showing expression of H2-D and H2-K on the cell surface of splenic B cells in comparison of 10- to 15-week-old female NOD, NOD-H2-D −/− , and NOD-H2-K −/− mice. (diabetesjournals.org)
- Representative flow cytometry showing CD4 vs. CD8 of gated CD45.1 + thymocytes in comparison of 10- to 15-week-old female NOD and NOD-H2-K −/− mice. (diabetesjournals.org)
- Representative flow cytometry showing among splenocytes Thy1.2 vs. FSC-A (top) and Thy1.2-gated CD4 vs. CD8 (bottom) from 10- to 15-week-old female mice. (diabetesjournals.org)
- Isolation of murine microglial cells for RNA analysis or flow cytometry. (mendeley.com)
- the phenotype and function of tumor-associated immune cells in peritoneal cavity of treated mice was analyzed by flow cytometry, and systemic antigen-specific immune response was evaluated by ELISA and cytotoxicity assay. (biomedcentral.com)
- Twenty-four hours after the last sensitization, challenged mice developed a marked airway inflammatory response characterized by the accumulation of total inflammatory cells (a 21-fold increase) in the bronchoalveolar space, similar in both mouse strains. (portlandpress.com)
- It is unclear whether this is due to a lack or a disproportionate expression of ET A receptors in these two murine strains, or in post-receptor transduction modulation, or different regulation of ET receptors in various pulmonary cells, after sensitization and challenge. (portlandpress.com)
- Next generation sequencing (NGS) data was generated for MLVs from two wild caught Mus musculus domesticus (from mainland France and Corsica) and for inbred laboratory mouse strains C3H, LP/J and SJL. (biomedcentral.com)
- Different MLVs are able to infect different hosts, i.e., they have different host specificity: xenotropic MLV ( Xmv ) elements have a broad host range but are unable to infect laboratory mouse host strains, while polytropic MLV elements have a more restricted host range but are able to infect house mouse strains [ 4 ]. (biomedcentral.com)
- We therefore sequenced and analyzed genome-wide exome (GWE) variants, including those aligned to the critical genetic interval, in Cmv5 -disparate mouse strains. (g3journal.org)
- This approach was developed as a platform for using GWE variants to define genomic regions of divergence and similarity in different mouse strains, while also validating the overall quality of GWE sequence data. (g3journal.org)
- Such studies are greatly facilitated by the availability of mutant and congenic strains of inbred mice which differ from the nonmutant or partner strains only with respect to one or another manifestation of the viral genome. (rupress.org)
- These mouse-cell-adapted (MCA-EV-A71) strains were generated by serial passage of a brainstem clinical isolate (EV71:BS) in a murine embryonic fibroblast (NIH/3T3) cell line. (nus.edu.sg)
- Mice inoculated with MCA-EV-A71 strains exhibited acute, severe disease, and some exhibited respiratory distress. (nus.edu.sg)
- tropos Gr. turning) were initially discovered in the New Zealand Black (NZB) mouse and later found to be present in many other mouse strains including wild mice. (wikipedia.org)
- In addition, it may be necessary to clone and sequence the ERV mch8 /Emv2 locus in these mouse strains to examine whether there are any sequence polymorphisms among the presumed loci in different mouse genomes. (biomedcentral.com)
- To study the direct role of CXCL1 on the genesis of primary melanoma lesions, transgenic mouse lines were established that express the murine homologue of CXCL1, murine macrophage inflammatory protein 2 (MIP-2), under the transcriptional control of the tyrosinase promoter/enhancer (Tyr-MIP-2) in the mice that were deficient or not deficient for INK4a/ARF. (aacrjournals.org)
- By contrast, the ctxAB mutant with an additional deletion in the actin-cross-linking repeats-in-toxin (RTX) toxin gene ( rtxA ) caused a less severe pathology and decreased serum levels of proinflammatory molecules interleukin (IL)-6 and murine macrophage inflammatory protein (MIP)-2. (rupress.org)
- The existence of the paracrine mechanism of lymphomagenesis is supported by studies showing that cell-type-specific expression of the KSHV G protein-coupled receptor (vGPCR) in lymphocytes of transgenic mice induces angioproliferative lesions characteristic of Kaposi's sarcoma ( 69 ). (asm.org)
- On murine T lymphocytes the A2aR is highly expressed ( 20 ), and after T-cell receptor (TCR) stimulation, A2aR mRNA levels increase by a factor of ∼10 ( 16 ). (physiology.org)
- Gene structure and functional analysis of the mouse nidogen-2 gene: nidogen-2 is not essential for basement membrane formation in mice," Molecular and Cellular Biology , vol. 22, no. 19, pp. 6820-6830, 2002. (hindawi.com)
- Transgenic (Tg) mice expressing the herpes simplex virus thymidine kinase gene ( HSV-Tk ) driven by the mouse GFAP promoter were used to render proliferating HSCs susceptible to killing in response to ganciclovir (GCV). (wiley.com)
- Devinoy E, Thépot D, Stinnakre MG, Fontaine ML, Grabowski H, Puissant C, Pavirani A, Houdebine LM (1994) High level production of human growth hormone in the milk of transgenic mice: the upstream region of the rabbit whey acidic protein (WAP) gene targets transgene expression to the mammary gland. (springer.com)
- Shi G, Chen H, Wu X, Zhou Y, Liu Z, Zheng T, Huang T (2009) A mWAP-hLF hybrid gene locus gave extremely high level expression of human lactoferrin in the milk of transgenic mice. (springer.com)
- Finally it would be possible to use these methods for the determination of specific effects of altered gene expression in platelets by using platelets from genetically engineered mice. (bio-protocol.org)
- pBROAD3 plasmids were designed for the expression of your favorite gene in virtually all tissues of new transgenic mice and rats . (invivogen.com)
- To this end, intestinal permeability and the release of zonulin (an endogenous mediator of gut permeability) in vitro, as well as proinflammatory gene expression and cytokine release by primary murine macrophage cultures, were measured. (jimmunol.org)
- The strong phenotype, stable evaluation and the potential for gene manipulation utilizing the presented method in mice will accelerate the translational research of myopia. (nature.com)
- After immunization with recombinant vaccinia virus encoding murine tyrosinase, we detected a robust AAD-restricted cytotoxic T lymphocyte (CTL) response to F MDGTMSQV in AAD transgenic mice in which the entire tyrosinase gene had been deleted by a radiation-induced mutation. (pubmedcentralcanada.ca)
- Here we describe the katun ( Ka ) mouse mutant, which harbours a mutation in the Zic3 gene that results in a PTC. (biologists.org)
- As the chromosomes of the wild-type mouse are all acrocentric, metaphase spreads of the WMP2 cells seam to be highly suited for physical gene mapping. (pasteur.fr)
- To address this need, we characterized mammary tumor gene expression profiles from 13 different murine models using DNA microarrays and compared the resulting data to those from human breast tumors. (biomedcentral.com)
- A KO/KI mouse was generated in which exon 1 of the Gpr120 gene (also known as Ffar4) was replaced in frame by LacZ, thereby allowing for regulated expression of β-galactosidase under the control of the endogenous GPR120 promoter. (sigmaaldrich.com)
- Nevertheless, early experiments targeting an oncogenic Kras allele to cytokeratin 19 (CK19)-expressing pancreatic ductal epithelium of mice failed to yield a neoplastic phenotype, with the caveat that the mutant allele was not expressed under endogenous regulatory elements ( 6 ). (pnas.org)
- Furthermore, higher concentrations of circulating cytokines in ApoE-/-/Bgn-/0 mice suggested a proinflammatory phenotype. (ahajournals.org)
- Cmah -deficient mdx mice display an accelerated disease onset and severe cardiac phenotype due to differences in glycosylation between humans and mice. (iospress.com)
- Other novel murine models include mdx52 , which harbors a deletion mutation in exon 52, a hot spot region in humans, and dystrophin/utrophin double-deficient ( dko ), which displays a severe dystrophic phenotype due the absence of utrophin, a dystrophin homolog. (iospress.com)
- Female mice, starting at eight to nine weeks of age, were treated for 27 weeks with 1) pravastatin, 2) L-4F, 3) L-4F plus pravastatin, or 4) vehicle control, followed by disease phenotype assessment. (pubmedcentralcanada.ca)
- However, genetic deletion of CD73 in mice is associated with a proinflammatory phenotype and CD73-derived adenosine appears to be quantitatively sufficient to inhibit platelet activation, and leukocyte adhesion to the vascular endothelium in vivo ( 15 ) by acting through the A2aR ( 47 ). (physiology.org)
- GPR120 (FFAR4) is preferentially expressed in pancreatic delta cells and regulates somatostatin secretion from murine islets of Langerhans. (sigmaaldrich.com)
- These studies demonstrated spontaneous IL-6 secretion from murine spleen slices directly after transfer into microsuperfusion chambers. (physiology.org)
- Simultaneous measurements of cardiac energetics using 31 P NMR spectroscopy and contractile performance of the intact beating heart revealed both a decrease in the free energy of ATP hydrolysis available to support contractile work and a marked inability to increase contractile performance upon acute inotropic challenge in hearts from R92Q mice. (jci.org)
- In the current study, we assessed the therapeutic effect of OLT1177, an orally active NLRP3 inflammasome inhibitor that is safe in humans, in murine acute arthritis models. (biomedcentral.com)
- Recently, we reported that MORG1 +/− mice are protected from renal injury induced by systemic hypoxia and acute renal ischemia-reperfusion injury via increased hypoxia-inducible factors (HIFs). (biomedcentral.com)
- EGFL6 Mouse Recombinant produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 273 amino acids (287-550a.a.) and having a molecular mass of 31.1kDa (Molecular size on SDS-PAGE will appear at approximately 28-40kDa). (prospecbio.com)
- BLMH Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 478 amino acids (1-455 aa) and having a molecular mass of 54.9 kDa. (prospecbio.com)
- Using a bacterial cDNA expression system, we found that recombinant proteins for each of the five full-length murine CYP2Cs metabolize arachidonic acid to different regio- and stereospecific products, including epoxyeicosatrienoic acids and hydroxyeicosatetraenoic acids. (aspetjournals.org)
- In order to study the interactions between tumor cells, platelets and endothelium, we have adapted methods used in coagulation research for the isolation of platelets and their reintroduction into mice. (bio-protocol.org)
- These methods have facilitated study of the interactions between platelets and tumor cells in tissue culture and in murine models. (bio-protocol.org)
- Then, the doses of challenge cells which produced 50% tumor deaths were calculated for immunized and control mice. (aacrjournals.org)
- We also examined TQ effects on the growth of C26 mouse colorectal carcinoma spheroids and assessed tumor invasion in vitro. (edu.lb)
- Tumor multiplicity was reduced at week 20 from 17.8 in the DMH group to 4.2 in mice injected with TQ. (edu.lb)
- Combined anti-PD-1/GITR mAb treatment remarkably inhibited peritoneal ID8 tumor growth with 20% of mice tumor free 90 days after tumor challenge while treatment with either anti-PD-1 or anti-GITR mAb alone exhibited little antitumor effect. (biomedcentral.com)
- More importantly, combined treatment of anti-PD-1/GITR mAb and chemotherapeutic drugs (cisplatin or paclitaxel) further increased the antitumor efficacy with 80% of mice obtaining tumor-free long-term survival in murine ID8 ovarian cancer and 4 T1 breast cancer models. (biomedcentral.com)
- Mu Prime models provide an ideal platform to investigate your novel surrogate or cross-reactive immunotherapies with competent murine immunity, and the ability to synchronize tumor growth for pharmacology studies. (crownbio.com)
- This means Mu Prime models mirror original mouse tumor histopathology and genetic profiles, with various differentiation phenotypes, rich microenvironments, and cancer stem cell driven disease. (crownbio.com)
- Mouse mammary tumor models have been designed to emulate genetic alterations found in human breast cancers, including inactivation of TP53, BRCA1, and RB, and overexpression of MYC and HER2/ERBB2/NEU. (biomedcentral.com)
- Outbred laboratory mice were inoculated at the age of 5, 10 and 21 days by oral and/or intranasal routes with 2 different (a lethal and a nonlethal) doses of the murine herpesvirus isolate 68 (MHV-68). (nih.gov)
- Our approach was to isolate CD8α + and CD8α − DCs from mouse spleen and to screen by representational difference analysis (RDA) for genes expressed uniquely in the CD8α + subset. (bloodjournal.org)
- Systemic lupus erythematosus (SLE) is a severe systemic chronic autoimmune disease and NZB/W F1 mice are commonly used to study this disease. (bmj.com)
- Here, we report that a unique Lactobacillus -predominated microbial community was rapidly attained in mice within 2 weeks of CR, which decreased the levels of circulating microbial antigens and systemic inflammatory markers such as tumour necrosis factor alpha (TNF-α). (biomedcentral.com)
- Recent genetically engineered mouse models of PDAC demonstrate a comparable morphologic spectrum of murine PanIN (mPanIN) lesions. (pnas.org)
- Since murine models are relatively easy to genetically manipulate, cost effective, and easily reproducible due to their short generation time, they have helped to elucidate the pathobiology of dystrophin deficiency and to assess therapies for treating DMD. (iospress.com)
- Studies have characterized conduction velocity in the right and left bundle branches (RBB, LBB) of normal and genetically engineered mice. (ahajournals.org)
- Mutations in many protein components of DGC (such as dystrophin, sarcoglycans or dystroglycans) lead to various forms of muscular dystrophy and murine models with various dystrophic phenotypes, partly because certain components of DGC are more crucial in function than others [ 7 ]. (iospress.com)
- Mouse models of Zic3 dysfunction also result in heterotaxy, indicating conserved mammalian function of this protein. (biologists.org)
- Atrioventricular propagation was recently studied in wild-type and mutant mice, 19,20 and it was reported that targeted disruption of the gap junction protein connexin40 (Cx40) led to conduction abnormalities. (ahajournals.org)
- E ) Percentage of human γ-globin protein compared with adult mouse globin chains (α, β-major, β-minor) measured by HPLC in RBCs at week 18. (jci.org)
- Here, we identified a novel role of the protein tyrosine phosphatase SHP-1 in the regulation of murine LFA-1-mediated adhesion in an allograft setting. (asm.org)
- This DNA segment and other defined viral subgenomic fragments have been used as 32P-labeled probes to identify and analyze the structure of integrated ecotropic viral DNA sequences in uninfected mouse genomes. (semanticscholar.org)
- In addition, we also performed detailed sequence comparisons to determine the presence of specific viral reference sequences in these mice. (biomedcentral.com)
- Methods:Male mice deficient in apolipoprotein E and BGN (ApoE-/-/Bgn-/0) were compared with their ApoE-/- littermates. (ahajournals.org)
- Here we provide details of the methods we have used for platelet isolation from mice and their staining for further microscopy and re-introduction into mice. (bio-protocol.org)
- Methods AIA was induced in mice. (bmj.com)
- In the present study, we investigated the roles of ETs in these two murine models of allergic asthma (AA). (portlandpress.com)
- Amyloid-beta (A beta) immunotherapy for Alzheimer's disease (AD) has good preclinical support from transgenic mouse models and clinical data suggesting that a long-term treatment effect is possible. (diva-portal.org)
- In this study, we evaluated TQ's therapeutic potential in two different mice colon cancer models [1,2-dimethyl hydrazine (DMH) and xenografts]. (edu.lb)
- In spontaneous models of lupus, tolerance induction was dependent on the generation of Foxp3 + Tregs in (NZB × SWR)F 1 ( 7 ) and (NZB × NZW)F 1 (BWF1) mice ( 8 ), and Treg transfers showed a significantly protective effect in BWF1 mice ( 9 ). (jimmunol.org)
- This is partially because of the lack of efficient murine myopic models that allow genetic manipulation at low cost. (nature.com)
- A dose-dependent protective response to immune mice serum was observed in both experimental models though the values of PI of mice were higher than those obtained for guinea pigs. (veterinaryworld.org)
- Recently, several murine models have been developed by our group and others to be more representative of the human DMD mutation types and phenotypes. (iospress.com)
- Is the Subject Area "Mouse models" applicable to this article? (plos.org)
- Although numerous mouse models of breast carcinomas have been developed, we do not know the extent to which any faithfully represent clinically significant human phenotypes. (biomedcentral.com)
- Many of the defining characteristics of human subtypes were conserved among the mouse models. (biomedcentral.com)
- Two models were chosen for study, the CD1 and the inducible nitric oxide synthase knockout (NOS2-/-) mice. (ajtmh.org)
- This ELISA antibody pair recognizes Mouse IL23. (antibodies-online.com)
- Here, we demonstrate that the humanized antibody BAN2401 and its murine version mAb158 exhibit a strong binding preference for A beta protofibrils over A beta monomers. (diva-portal.org)
- The GK1.5 antibody reportedly blocks binding of the RM4-5 and H129.19, but not RM4-4 mouse CD4-specific antibodies. (fishersci.com)
- Compound genetic ablation of nidogen 1 and 2 causes basement membrane defects and perinatal lethality in mice," Molecular and Cellular Biology , vol. 25, no. 15, pp. 6846-6856, 2005. (hindawi.com)
- We conclude that in the appropriate genetic context, the differentiated acinar cell compartment in adult mice retains its susceptibility for spontaneous transformation into mPanIN lesions, a finding with potential relevance vis-à-vis the origins of PDAC. (pnas.org)
- For instance, mdx mice on a DBA/2 genetic background, developed by Fukada et al. (iospress.com)
- XMRV was generated unintentionally in the laboratory, through genetic recombination between two mouse retroviruses during propagation of a prostate-cancer cell line in the mid-1990s. (wikipedia.org)
- Genetic manipulation of MORG1 expression has revealed that MORG1 −/− mice exhibit embryonic lethality, whereas MORG1 +/− mice did not show phenotypic differences with the wild-type mice. (biomedcentral.com)
- The absence of nidogen 1 does not affect murine basement membrane formation," Molecular and Cellular Biology , vol. 20, no. 18, pp. 7007-7012, 2000. (hindawi.com)
- It was subsequently demonstrated that detection of XMRV in cancer tissues was due to contamination of some molecular biology reagents with mouse genomic DNA [ 6 ] and that XMRV was actually a laboratory derived virus that originated from recombination in cell culture between two naturally occurring precursor viruses (PreXMRV-1 and PreXMRV-2, both endogenous retroviruses). (biomedcentral.com)
- In contrast, captive grey mouse lemurs show senescence in their ability to regain lost body mass and a reverse sex bias in lifespan (favouring males) [ 1189 ]. (senescence.info)
- Long-term intake of fish oil increases oxidative stress and decreases lifespan in senescence-accelerated mice. (semanticscholar.org)
- Severe exudative pneumonia with haematogenous dissemination of the virus to liver, heart muscle, and kidneys developed in the 5-day-old as well as in a part of the 10-day-old mice. (nih.gov)
- Inbred mice chronically infected with the virus develop a lymphoproliferative disease (LPD) similar to that seen in patients infected with Epstein-Barr virus. (nih.gov)
- However, murine gammaherpes virus 68 (MHV) is a closely related mouse virus and is effectively the murine equivalent of EBV 11 - 13 . (ersjournals.com)
- Alcohol further suppressed immune functions in retrovirally infected mice beyond that caused by the virus. (openrepository.com)
- Adult mice that had been infected with LP-BM5 virus for 3, 4, or 5 months, when challenged by the oral route with Cryptosporidium, exhibited significant colonization on the intestinal villiae by this organism 10 days following oral challenge. (openrepository.com)