Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
Deliberate breeding of two different individuals that results in offspring that carry part of the genetic material of each parent. The parent organisms must be genetically compatible and may be from different varieties or closely related species.
Any method used for determining the location of and relative distances between genes on a chromosome.
Genetic loci associated with a QUANTITATIVE TRAIT.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
The mating of plants or non-human animals which are closely related genetically.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.
Complex nucleoprotein structures which contain the genomic DNA and are part of the CELL NUCLEUS of MAMMALS.
A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.
A family of the order Rodentia containing 250 genera including the two genera Mus (MICE) and Rattus (RATS), from which the laboratory inbred strains are developed. The fifteen subfamilies are SIGMODONTINAE (New World mice and rats), CRICETINAE, Spalacinae, Myospalacinae, Lophiomyinae, ARVICOLINAE, Platacanthomyinae, Nesomyinae, Otomyinae, Rhizomyinae, GERBILLINAE, Dendromurinae, Cricetomyinae, MURINAE (Old World mice and rats), and Hydromyinae.
The co-inheritance of two or more non-allelic GENES due to their being located more or less closely on the same CHROMOSOME.
The experimental study of the relationship between the genotype of an organism and its behavior. The scope includes the effects of genes on simple sensory processes to complex organization of the nervous system.
Genotypic differences observed among individuals in a population.
The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.
Animals that are generated from breeding two genetically dissimilar strains of the same species.
Mouse strains constructed to possess identical genotypes except for a difference at a single gene locus.
Production of new arrangements of DNA by various mechanisms such as assortment and segregation, CROSSING OVER; GENE CONVERSION; GENETIC TRANSFORMATION; GENETIC CONJUGATION; GENETIC TRANSDUCTION; or mixed infection of viruses.
A constitution or condition of the body which makes the tissues react in special ways to certain extrinsic stimuli and thus tends to make the individual more than usually susceptible to certain diseases.
Variant forms of the same gene, occupying the same locus on homologous CHROMOSOMES, and governing the variants in production of the same gene product.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Constituent of 30S subunit prokaryotic ribosomes containing 1600 nucleotides and 21 proteins. 16S rRNA is involved in initiation of polypeptide synthesis.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
The genetic process of crossbreeding between genetically dissimilar parents to produce a hybrid.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
DNA sequences encoding RIBOSOMAL RNA and the segments of DNA separating the individual ribosomal RNA genes, referred to as RIBOSOMAL SPACER DNA.
A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms.
Procedures for identifying types and strains of bacteria. The most frequently employed typing systems are BACTERIOPHAGE TYPING and SEROTYPING as well as bacteriocin typing and biotyping.
A convulsant primarily used in experimental animals. It was formerly used to induce convulsions as a alternative to electroshock therapy.
The functional hereditary units of BACTERIA.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
A characteristic showing quantitative inheritance such as SKIN PIGMENTATION in humans. (From A Dictionary of Genetics, 4th ed)
The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenic capacity of an organism is determined by its VIRULENCE FACTORS.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Widely used technique which exploits the ability of complementary sequences in single-stranded DNAs or RNAs to pair with each other to form a double helix. Hybridization can take place between two complimentary DNA sequences, between a single-stranded DNA and a complementary RNA, or between two RNA sequences. The technique is used to detect and isolate specific sequences, measure homology, or define other characteristics of one or both strands. (Kendrew, Encyclopedia of Molecular Biology, 1994, p503)
The genetic complement of an organism, including all of its GENES, as represented in its DNA, or in some cases, its RNA.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Variation occurring within a species in the presence or length of DNA fragment generated by a specific endonuclease at a specific site in the genome. Such variations are generated by mutations that create or abolish recognition sites for these enzymes or change the length of the fragment.
In a prokaryotic cell or in the nucleus of a eukaryotic cell, a structure consisting of or containing DNA which carries the genetic information essential to the cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
A phenotypically recognizable genetic trait which can be used to identify a genetic locus, a linkage group, or a recombination event.
The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level.
Species of GAMMARETROVIRUS, containing many well-defined strains, producing leukemia in mice. Disease is commonly induced by injecting filtrates of propagable tumors into newborn mice.

Standardized nomenclature for inbred strains of mice: sixth listing. (1/15570)

Rules for designating inbred strains of mice are presented, along with a list of strains with their origins and characteristics, a table of biochemical polymorphisms, and standard subline designations.  (+info)

Features of the immune response to DNA in mice. I. Genetic control. (2/15570)

The genetic control of the immune response to DNA was studied in various strains of mice F1 hybrids and corresponding back-crosses immunized with single stranded DNA complexed to methylated bovine serum albumin. Anti-DNA antibody response was measured by radioimmuno-logical technique. High responder, low responder, and intermediate responder strains were found and the ability to respond to DNA was characterized as a dominant genetic trait which is not linked to the major locus of histocompatibility. Studies in back-crosses suggested that this immune response is under multigenic control. High responder mice produce both anti-double stranded DNA and anti-single stranded DNA 7S and 19S antibodies, while low responder mice produce mainly anti-single stranded DNA 19S antibodies.  (+info)

Antitumor effect of allogenic fibroblasts engineered to express Fas ligand (FasL). (3/15570)

Fas ligand is a type II transmembrane protein which can induce apoptosis in Fas-expressing cells. Recent reports indicate that expression of FasL in transplanted cells may cause graft rejection and, on the other hand, tumor cells may lose their tumorigenicity when they are engineered to express FasL. These effects could be related to recruitment of neutrophils by FasL with activation of their cytotoxic machinery. In this study we investigated the antitumor effect of allogenic fibroblasts engineered to express FasL. Fibroblasts engineered to express FasL (PA317/FasL) did not exert toxic effects on transformed liver cell line (BNL) or colon cancer cell line (CT26) in vitro, but they could abrogate their tumorigenicity in vivo. Histological examination of the site of implantation of BNL cells mixed with PA317/FasL revealed massive infiltration of polymorphonuclear neutrophils and mononuclear cells. A specific immune protective effect was observed in animals primed with a mixture of BNL or CT26 and PA317/FasL cells. Rechallenge with tumor cells 14 or 100 days after priming resulted in protection of 100 or 50% of animals, respectively. This protective effect was due to CD8+ cells since depletion of CD8+ led to tumor formation. In addition, treatment of pre-established BNL tumors with a subcutaneous injection of BNL and PA317/FasL cell mixture at a distant site caused significant inhibition of tumor growth. These data demonstrate that allogenic cells engineered with FasL are able to abolish tumor growth and induce specific protective immunity when they are mixed with neoplastic cells.  (+info)

Phenotype of mice and macrophages deficient in both phagocyte oxidase and inducible nitric oxide synthase. (4/15570)

The two genetically established antimicrobial mechanisms of macrophages are production of reactive oxygen intermediates by phagocyte oxidase (phox) and reactive nitrogen intermediates by inducible nitric oxide synthase (NOS2). Mice doubly deficient in both enzymes (gp91(phox-/-)/NOS2(-/-)) formed massive abscesses containing commensal organisms, mostly enteric bacteria, even when reared under specific pathogen-free conditions with antibiotics. Neither parental strain showed such infections. Thus, phox and NOS2 appear to compensate for each other's deficiency in providing resistance to indigenous bacteria, and no other pathway does so fully. Macrophages from gp91(phox-/-)/NOS2(-/-) mice could not kill virulent Listeria. Their killing of S. typhimurium, E. coli, and attenuated Listeria was markedly diminished but demonstrable, establishing the existence of a mechanism of macrophage antibacterial activity independent of phox and NOS2.  (+info)

Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. (5/15570)

We have generated mice with a cell type-specific disruption of the Stat3 gene in macrophages and neutrophils. The mutant mice are highly susceptible to endotoxin shock with increased production of inflammatory cytokines such as TNF alpha, IL-1, IFN gamma, and IL-6. Endotoxin-induced production of inflammatory cytokines is augmented because the suppressive effects of IL-10 on inflammatory cytokine production from macrophages and neutrophils are completely abolished. The mice show a polarized immune response toward the Th1 type and develop chronic enterocolitis with age. Taken together, Stat3 plays a critical role in deactivation of macrophages and neutrophils mainly exerted by IL-10.  (+info)

Thymic selection by a single MHC/peptide ligand: autoreactive T cells are low-affinity cells. (6/15570)

In H2-M- mice, the presence of a single peptide, CLIP, bound to MHC class II molecules generates a diverse repertoire of CD4+ cells. In these mice, typical self-peptides are not bound to class II molecules, with the result that a very high proportion of H2-M- CD4+ cells are responsive to the various peptides displayed on normal MHC-compatible APC. We show here, however, that such "self" reactivity is controlled by low-affinity CD4+ cells. These cells give spectacularly high proliferative responses but are virtually unreactive in certain other assays, e.g., skin graft rejection; responses to MHC alloantigens, by contrast, are intense in all assays. Possible explanations for why thymic selection directed to a single peptide curtails self specificity without affecting alloreactivity are discussed.  (+info)

High-linoleate and high-alpha-linolenate diets affect learning ability and natural behavior in SAMR1 mice. (7/15570)

Semipurified diets incorporating either perilla oil [high in alpha-linolenate, 18:3(n-3)] or safflower oil [high in linoleate, 18:2(n-6)] were fed to senescence-resistant SAMR1 mouse dams and their pups. Male offspring at 15 mo were examined using behavioral tests. In the open field test, locomotor activity during a 5-min period was significantly higher in the safflower oil group than in the perilla oil group. Observations of the circadian rhythm (48 h) of spontaneous motor activity indicated that the safflower oil group was more active than the perilla oil group during the first and second dark periods. The total number of responses to positive and negative stimuli was higher in the safflower oil group than in the perilla oil group in the light and dark discrimination learning test, but the correct response ratio was lower in the safflower oil group. The difference in the (n-6)/(n-3) ratios of the diets reflected the proportions of (n-6) polyunsaturated fatty acids, rather than those of (n-3) polyunsaturated fatty acids in the brain total fatty acids, and in the proportions of (n-6) and (n-3) polyunsaturated fatty acids in the total polyunsaturated fatty acids of the brain phospholipids. These results suggest that in SAMR1 mice, the dietary alpha-linolenate/linoleate balance affects the (n-6)/(n-3) ratio of brain phospholipids, and this may modify emotional reactivity and learning ability.  (+info)

Cardiomegaly in the juvenile visceral steatosis (JVS) mouse is reduced with acute elevation of heart short-chain acyl-carnitine level after L-carnitine injection. (8/15570)

The long-term administration of L-carnitine was very effective in preventing cardiomegaly in juvenile visceral steatosis (JVS) mice, which was confirmed by heart weight as well as the lipid contents in heart tissue. After i.p. injection of L-carnitine, the concentration of free carnitine in heart remained constant, although serum free carnitine level increased up to 80-fold. On the other hand, a significant increase in short-chain acyl-carnitine level in heart was observed. These results suggest that increased levels of short-chain acyl-carnitine, not free carnitine, might be a key compound in the protective effect of L-carnitine administration in JVS mice.  (+info)

BACKGROUND: Adenosine-to-inosine (A-to-I) editing is a site-selective post-transcriptional alteration of double-stranded RNA by ADAR deaminases that is crucial for homeostasis and development. Recently the Mouse Genomes Project generated genome sequences for 17 laboratory mouse strains and rich catalogues of variants. We also generated RNA-seq data from whole brain RNA from 15 of the sequenced strains. RESULTS: Here we present a computational approach that takes an initial set of transcriptome/genome mismatch sites and filters these calls taking into account systematic biases in alignment, single nucleotide variant calling, and sequencing depth to identify RNA editing sites with high accuracy. We applied this approach to our panel of mouse strain transcriptomes identifying 7,389 editing sites with an estimated false-discovery rate of between 2.9 and 10.5%. The overwhelming majority of these edits were of the A-to-I type, with less than 2.4% not of this class, and only three of these edits could not be
BACKGROUND: Adenosine-to-inosine (A-to-I) editing is a site-selective post-transcriptional alteration of double-stranded RNA by ADAR deaminases that is crucial for homeostasis and development. Recently the Mouse Genomes Project generated genome sequences for 17 laboratory mouse strains and rich catalogues of variants. We also generated RNA-seq data from whole brain RNA from 15 of the sequenced strains. RESULTS: Here we present a computational approach that takes an initial set of transcriptome/genome mismatch sites and filters these calls taking into account systematic biases in alignment, single nucleotide variant calling, and sequencing depth to identify RNA editing sites with high accuracy. We applied this approach to our panel of mouse strain transcriptomes identifying 7,389 editing sites with an estimated false-discovery rate of between 2.9 and 10.5%. The overwhelming majority of these edits were of the A-to-I type, with less than 2.4% not of this class, and only three of these edits could not be
In view of the Tnfa gene location within the major histocompatibility (MHC) region and reports of its importance in disease protection activity, this paper examines the TNF a genes of a number of different mouse strains which were known to be of different disease response phenotypes. Twelve inbred mouse strains were studied. In a separate study, the repeat length in the (CA) n microsatellite located within the Tnfa promoter region of these 12 inbred mouse strains was determined, High relative molecular mass genomic (chramosomal) DNA of the inbred mouse strains was obtained from the Jackson Laboratory. The results of the study shows that pCR-RFLps were not detected in the promoter region. Two haplotypes were defined in the first intron and three haplotypes could be defined in 3 UTR in the 12 strains based on PCR-RFLP genotypes and, moreover, these were not strictly concordant with serologically defined H2 haplotypes ...
Read Genetic structure of the LXS panel of recombinant inbred mouse strains: a powerful resource for complex trait analysis, Mammalian Genome on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
TY - JOUR. T1 - Evaluation of heritable determinants of blood and brain serotonin homeostasis using recombinant inbred mice. AU - Ye, R.. AU - Carneiro, A. M.D.. AU - Airey, D.. AU - Sanders-Bush, E.. AU - Williams, Robert. AU - Lu, Lu. AU - Wang, J.. AU - Zhang, B.. AU - Blakely, R. D.. PY - 2014/3/1. Y1 - 2014/3/1. N2 - The biogenic amine serotonin (5-HT, 5-hydroxytryptamine) exerts powerful, modulatory control over multiple physiological functions in the brain and periphery, ranging from mood and appetite to vasoconstriction and gastrointestinal motility. In order to gain insight into shared and distinct molecular and phenotypic networks linked to variations in 5-HT homeostasis, we capitalized on the stable genetic variation present in recombinant inbred mouse strains. This family of strains, all derived from crosses between C57BL/6J and DBA/2J (BXD) parents, represents a unique, community resource with approximately 40years of assembled phenotype data that can be exploited to explore and ...
Mice from eight inbred strains were studied for their acute sensitivity to ethanol as indexed by the degree of hypothermia (HT), indexed as the reduction from pre-injection baseline of their body temp
Genetic and environmental factors interact throughout life and give rise to individual differences, i.e., individuality. The diversifying effect of environmental factors is counteracted by genetic mechanisms to yield persistence of specific features (robustness). Here, we compared robustness between cohorts of isogenic mice of eight different commonly used strains by analyzing to what extent environmental variation contributed to individuality in each of the eight genotypes, using a previously published dataset. Behavior was assessed in the home-cage, providing control over environmental factors, to reveal within-strain variability in numerous spontaneous behaviors. Indeed, despite standardization and in line with previous studies, substantial variability among mice of the same inbred strain was observed. Strikingly, across a multidimensional set of 115 behavioral parameters, several strains consistently ranked high in within-strain variability (DBA/2J, 129S1/Sv A/J and NOD/LtJ), whereas other ...
Alterations in mitochondrial DNA (mtDNA) were once thought to be predominantly innocuous to cell growth. Recent evidence suggests that mtDNA undergo naturally occurring alterations, including mutations and polymorphisms, which profoundly affect the cells in which they appear and contribute to a variety of diseases, including cardiovascular disease, diabetes, and cancer. Furthermore, interplay between mtDNA and nuclear DNA has been found in cancer cells, necessitating consideration of these complex interactions for future studies of cancer mutations and polymorphisms. In this issue of Cancer Research, Vivian and colleagues utilize a unique mouse model, called Mitochondrial Nuclear eXchange mice, that contain the nuclear DNA from one inbred mouse strain, and the mtDNA from a different inbred mouse strain to examine the genome-wide nuclear DNA methylation and gene expression patterns of brain tissue. Results demonstrated there were alterations in nuclear DNA expression and DNA methylation driven by ...
Limitation of Number of Strains and Persistence of False Positive Loci in QTL Mapping Using Recombinant Inbred Strains. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Watson, J; Riblet, R; and Taylor, B A., The response of recombinant inbred strains of mice to bacterial lipopolysaccharides. (1977). Subject Strain Bibliography 1977. 3712 ...
Hereditary Factors:, Organs:, Serology:, Transplantation:, Congenic Resistant Lines: B10.D2/O, Genes: H-2 - Histocompatibility-2, nu - Nude, Strains: BALB/C, C3H, C57BL/6, DBA/2 (212), Unknown:. ...
|p||em||strong||/strong||/em|The wild-derived inbred strain SPRET/Ei is often used in crosses with common inbred strains to create highly polymorphic panels for genetic mapping. SPRET/Ei may be useful for studies relating to inflammatory disorders.|/p|
The breadth of genetic and phenotypic variation among inbred strains is often underappreciated because assessments include only a limited number of strains. Evaluation of a larger collection of inbred strains provides not only a greater understanding of this variation but collectively mimics much of …
The BXD set of RI strains is used in the genetic analysis of numerous complex or potentially complex physiologic phenotypes. The BXD strains are derived from the C57BL/6J (Stock No. 000664) and DBA/2J (Stock No. 000671) progenitor strains.
هدف: روش‏های انجمادی متفاوتی برای انجماد بافت تخمدان بیماران در معرض خطر ناباروری استفاده می‏شود. اتیلن گلیکول، دی متیل سولفوکساید و پروپاندیول، با خاصیت تشکیل کریستال‏های یخ کمتر به‏عنوان محلول‏های انجمادی نفوذپذیر پایه‏ای در مقایسه با انواع دیگر توصیه شده‏است. در مطالعه حاضر آثار دو روش انجماد شیشه‏ای متفاوت روی بافت کامل تخمدان موش نابالغ با استفاده از رنگ‏آمیزی تریپان بلو بررسی شد. مواد و روش‏ها: تخمدان موش‏های 8 روزه نژاد NMRI، پس از جداسازی در گروه‏های کنترل غیر انجمادی، انجمادی 1 و انجمادی 2 دسته‏بندی شدند. محلول انجمادی 1 از محیط پایه α-MEM،
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The Collaborative Cross (CC) represents a large collection of new inbred mouse strains created by the mouse genetics community aimed at revolutionizing the study of complex genetic traits and diseases. Derived from classical inbred strains and wild-derived strains, the CC captures nearly 90% of known genetic variation in laboratory mice, far surpassing more commonly used inbred strains. The CC is a tool to integrate studies of gene function and gene networks, allowing the prediction and testing of biological models based on the whole organism, critical to the development of personalized therapies for humans. Genome Research has published three articles online in-advance utilizing strains from the emerging Collaborative Cross mouse strains.. 1. Collaborative Cross strains facilitate mapping of causative loci. In this work, Aylor and colleagues performed an experiment called the the pre-CC study, the first genetic data and analysis from the emerging strains of the CC. Their investigation ...
Han Kyu Lee, Samuel J. Widmayer, Min-Nung Huang, David L. Aylor and Douglas A. Marchuk. GENETICS 213:2 (October 2019). To identify genes involved in cerebral infarction we have employed a forward genetic approach in inbred mouse strains, using quantitative trait locus (QTL) mapping for cerebral infarct volume after middle cerebral artery occlusion. We had previously observed that infarct volume is inversely correlated with cerebral collateral vessel density in most strains. In this study, we expanded the pool of allelic variation among classical inbred mouse strains by utilizing the eight founder strains of the Collaborative Cross and found a wild-derived strain, WSB/EiJ, that breaks this general rule that collateral vessel density inversely correlates with infarct volume. WSB/EiJ and another wild-derived strain, CAST/EiJ, show the highest collateral vessel densities of any inbred strain, but infarct volume of WSB/EiJ mice is 8.7-fold larger than that of CAST/EiJ mice. QTL mapping between these ...
In this study, we demonstrated that in vivo administration of anti-CD25 mAb (PC61) caused regression of tumors that grew progressively in syngeneic mice and killed them eventually. The tumors used were five leukemias, a myeloma, and two sarcomas derived from four different inbred mouse strains. The effect of anti-CD25 mAb (PC61) was observed on six of the eight tumors. Administration of anti-CD25 mAb (PC61) resulted in a reduction in CD4+CD25+ cells in the peripheral lymphoid tissues. These findings suggested that CD4+CD25+ immunoregulatory cells were involved in the growth of those tumors. Tumor regression was observed even 2-3 months after PC61-treatment. Kinetic analysis showed that the administration of anti-CD25 mAb (PC61) later than day 2 after tumor inoculation caused no tumor regression. This could be due to an insufficient activation of effector cells for proliferating tumor cells by late depletion of CD4+CD25+ T cells. Alternatively, it could be due to a failure in the activation of ...
Mouse complement component C1q is a serum glycoprotein which consists of six A chains, six B chains and six C chains. The three polypeptides are 223, 228, and 217 residues long, respectively, and are encoded by three genes. DNA probes for mouse C1q A, B, and C chains were hybridized to Southern blots of DNA obtained from various inbred mouse strains. On the basis of fragment length polymorphisms, two different alleles of each of the genes could be identified. The distribution of these alleles was determined in the BXD and LXPL recombinant inbred strain series. Comparison with previously reported strain distribution patterns shows that the genes encoding mouse C1q map to the same locus on distal chromosome 4. Overlapping clones spanning the entire gene cluster of C1q were isolated from genomic libraries using specific cDNA probes. The three genes C1qA, C1qB, and C1qC are closely arranged on a 19 kilobase stretch of DNA in the 5 to 3 orientation A-C-B. Each gene consists of two exons separated ...
Age Related Survival and Spontaneous Disease Phenotypes in Selected Genetically Diverse Inbred Laboratory Mice is a study designed to develop a comprehensive reference benchmark database and clinical evaluation of 10 genetically diverse inbred strains of classical laboratory and wild-derived mice. ...
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Male and Female Mice: 129S1/SvImJ; Male and Female Mice: A/J; Male and Female Mice: AKR/J; Male and Female Mice: B6C3F1; Male and Female Mice: BALB/cByJ; Male and Female Mice: BTBR T+ tf/J 2; Male and Female Mice: C3H/HeJ; Male and Female Mice: C57BL/6; Male and Female Mice: CAST/EiJ (M. m. castaneus); Male and Female Mice: DBA/2 Jackson; Male and Female Mice: FVB/NJ; Male and Female Mice: KK/HIJ; Male and Female Mice: MOLF/EiJ (M. m. molossinus); Male and Female Mice: NOD/LtJ; Male and Female Mice: NZW/LacJ; Male and Female Mice: PWD/PhJ (M. m. musculus); Male and Female Mice: WSB/EiJ (M. m. domesticus ...
The inheritance of B-cell responsiveness to lipopolysaccharide (LPS) was studied in 55 crosses between mice of the low-responder strain C3H/HeJ and the high-responder strains B10.5M and C3H/Tif. F1 hybrid mice between the low-and the high-responder strains, showed in every case responses which were intermediate between the responses obtained with each parent. The responsiveness among F2 hybrid and backcross mice to either high- or low-responder parents, segregated into intermediate, high, or low categories, respectively. The present results are compatible with the hypothesis that responsiveness to LPS is determined by one single, codominantly expressed, autosomal gene. The capacity to develop a specific thymus-independent response to a hapten-LPS conjugate, also under genetical control, was found to segregate together with the capacity to develop polyclonal responses to LPS. ...
History of the Swiss albino mouse. The CD-1 mice, an outbred stock of albino mice, are based on the Swiss mouse colony maintained at The Rockefeller Institute for Medical Research, starting from two males and seven females in 1926 (24). This stock was derived from a colony of 200 mice obtained by investigators at the Pasteur Institute from a local dealer. Genetic analysis supports the claims of commercial breeders that colonies of outbred Swiss mice have not been supplemented by non-Swiss mice, as Swiss mice are genetically distinct from other mouse stocks (29). The Swiss mouse stocks may be considered an island population, isolated from migration. The C57BL/6 inbred mouse strain was established in 1921 from a breeder pair (female 57 and male 52) from Abbie Lathrops mouse colonies. The C57BLKS/J inbred strains are a derivative strain of C57BL/6J that was genetically contaminated, probably by DBA/2J (25). Information about other strains of mice relevant to this discussion can be obtained from a ...
SDS- PAGE of OMPs isolated from 4 various strains.1-2: S12, and S13 (strains investigated for pAbs production), 3: MW marker, 4: S3, 5: S7
The genetic basis of the control of acute splenic MCMV infection was studied after intraperitoneal inoculation of the virus. Classical Mendelian analyses using C57BL/6 (resistant) and BALB/c (susceptible) parental strains disclosed an autosomal dominant non-H-2 gene that regulates splenic virus replication. The probable location of this gene, to which we have assigned the symbol Cmv-1, is on chromosome 6 as defined by the strain distribution pattern of splenic MCMV replication in CXB recombinant inbred mice. Although there is a similar hierarchy of resistance to MCMV and HSV-1 with respect to the C57BL and BALB genetic backgrounds, the strain distribution pattern of HSV-1 replication in recombinant inbred mice suggests that Cmv-1 is not involved in restricting the spread of this virus. This is the first clear identification of a non-H-2 gene regulating the magnitude of MCMV infection. Elucidation of the function of this gene may be a fundamental step towards understanding the control of systemic ...
This correspondence was written in response to the comments by Young et al. Following careful evaluation of the relevant dataset, each of the points brought up by Young et al. has been addressed in this response. We anticipate this will clarify our findings regarding ERVmch8, an ecotropic endogenous retrovirus that was shown to have cerebellum-specific and age-dependent expression patterns in C57BL/6J mice.
First, a number of transcripts had distinct transcriptional activity between the two lines of mice at all time points. For example, FVB mice had consistently four- to eight-fold higher expression of the adenosine A2B receptor gene (Adora2b).. Second, a group of genes, although consistently overexpressed in FVB mice compared to SW mice, also exhibited different expression as a function of time during infection. The Sorting nexin gene (Snx6; overexpressed in FVB mice by 16- to 31-fold compared with SW mice) had increased expression at 4 dpi by approximately 2-fold in both lines of mice. However, at 9 dpi, expression of Snx6 remained elevated in FVB mice, but returned to normal in SW mice. Another example was proton-dependent high affinity oligopeptide transporter Pept2 (Slc15a2), which was overexpressed in FVB mice by 15- to 51-fold. Slc15a2 was upregulated in infected SW mice by 2-fold at 4 dpi and downregulated by 4-fold at 9 dpi, whereas in infected FVB mice its expression decreased by 11-fold ...
Our studies using systemic ribozyme-based targeting of TER suggest a direct link between the functional activity of the telomerase complex and the metastatic progression of B16-F10 melanoma in tumor-bearing C57Bl/6 mice. That cationic liposome:DNA complex-based ribozyme targeting was able to produce significant antitumor effects in a mouse tumor model system is of significance because of the potential challenges inherent in using such a model. Laboratory mouse strains, such as the one used here, have very long telomeres and high telomerase activity in many of its normal tissues (26) . Thus, systemic targeting of telomerase in this system might have been expected to produce either widespread toxicity (if successful in every organ), or no effects given the time frame over which the level of telomerase complex was reduced.. The lack of antitumor activity of the disabled mutant anti-TER 180 ribozyme strongly suggests that the in vivo mechanism of ribozyme action is TER cleavage. We note that ...
Cytosol polypeptides from mouse liver have been examined using twodimensional electrophoresis. About 250 spots were readily discernible. When cytosols from strains BALB/cBy and C57BL/6By were compared, eight genetically determined differences were observed. Other strain pairs show comparable numbers of differences. These eight phenotypes were scored in seven recombinant inbred lines derived from the two parental strains, and their strain distribution patterns were compared with previously determined patterns for other genetic markers that differ between the two progenitor strains. Using this information, tentative chromosome assignments for the genes controlling five of the variant phenotypes have been made, and two of the assignments have been confirmed using congenic resistant strains. These eight genes will be useful reference markers in fiiture crosses designed to map new genes.. ...
Eight standard inbred mouse strains were evaluated for ethanol effects on a refined battery of behavioral tests in a study that was originally designed to assess the influence of rat odors in the colony on mouse behaviors. As part of the design of the study, two experimenters conducted the tests, an …
Results of our chimaera experiments revealed no evidence that BALB/c cells were preferentially allocated to the mTE but indicated they were at a selective disadvantage between E4.5 and E8.5. We confirmed previous reports that preimplantation BALB/c embryos lagged behind embryos of some other strains and showed that the relative stage of development attained by E2.5 embryos of different strains correlated with the contribution they made to chimaeras. This suggests that the poor contribution of BALB/c embryos to aggregation chimaeras is at least partly because they lag behind their partner embryos, due to delayed or slow development.. In principle, heterosis of non-inbred partner embryos might also have contributed to the poor contribution of BALB/c cells in BALB/c↔BF2, BALB/c↔(BF1×TGB) and BALB/c↔(BF1×TP6.3) chimaeras, if hybrid cells outgrow BALB/c cells. However, this does not explain the differences in compositions of (BALB/c×AF1)↔BF2 and (AF1×BALB/c)↔BF2 chimaeras (West et al., ...
The ability of various B10 congenic resistant strains to respond to the alloantigen H-2.2 was tested. High and low antibody-producing strains were distinguished by their anti-H-2.2 hemagglutinating respones. However, these strains do not differ in their ability to respond to these antigenic differences in the mixed lymphocyte culture. The humoral response to the H-2.2 alloantigen was shown to be controlled by two interacting genes localized within the H-2 complex. Thus, F1 hybrids prepared between parental low responder strains could yield high level immune responses. In addition, strains bearing recombinant H-2 haplotypes were used to map the two distinct genes controlling the immune response. The alleles at each locus were shown to be highly polymorphic as evidenced by the asymmetric complementation patterns observed. The restricted interactions of specific alleles was termed coupled complementation. The significance of the results in the terms of mechanisms of Ir gene control are discussed. ...
Read Mind the gap: analysis of marker-assisted breeding strategies for inbred mouse strains, Mammalian Genome on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
Scientists are quickly pointing out that the use of a single inbred mouse strain as was the case in this study, is not representative. Furthermore it is known that certain inbred mouse strains are resistant to septic shock, whereas others are much more susceptible. So yes the use of a certain inbred mouse strain in one study failed to translate into medicines for mankind and illustrates the limits of this particular strain for a given research or disease, however in my mind the article also reminds us of the importance of choosing the adequate or most valid animal model for a study. If I am not mistaken certain countries demand the use of two different animal species in studies such as for example rodents and primates. I now better understand the logic behind such a policy ...
The UH Gene-Server has been updated in three directories, highlights below. REMINDER: The UH Gene-Server is a volunteer effort. Because of a numbe of technical problems, the server does *not* have the latest GenBank and PIR releases; however this will be corrected during the last week of December. New Mac Software: Many PLOTA additons-power spectra of protein seqs, secondary structure prediction, etc. New MacLigand Latest Disinfectant (ver. 2.4), Gatekeeper (1.1.1) and Gatekeeper-Aid (1.1). Updated & bug fixed RIMGR by K. Mannly (mouse inbred strain db mgr). New Unix Software: Tom Schniders SEQUENCE LOGO software New Bio-Matrix files: AI-Molecular Biology Database by Larry Hunter, with registration form. To request any of these files, first start by sending a mail message to gene-server at bchs.uh.edu or gene-server%bchs.uh.edu at CUNYVM from BITNET. The Subject: line should be one of: Subject: HELP Subject: SEND MAC INDEX Subject: SEND MATRIX INDEX or Subject: SEND UNIX INDEX There are HELP ...
We thank Vendrame and Dotta (1) for their interesting perspective regarding our recently published study investigating the role of interleukin-16 (IL-16) in the development of insulitis and type 1 diabetes in female NOD mice (2). On the basis of previous studies correlating suboptimal activation of caspase-3 with the development of autoimmunity in the clinical setting (3,4), they propose a similar condition might exist in NOD mice, resulting in defective secretion of mature IL-16. Although we have not directly examined this possibility, it must be considered that many studies have wrestled with the difficulty in detecting secreted IL-16 in several mouse strains used to examine inflammatory responses (2,5). This likely reflects the biology of mature IL-16, which is active at concentrations as low as 10−11 M, and indicates that the low levels of intrapancreatic mature IL-16 detected during the development of insulitis is not restricted only to the NOD genetic background.. However, the notion ...
ei,j,k. where b0 is an intercept term, bs(h) is the regression coefficient associated with the effect of the hth strain, br(g) is the regression coefficient associated with the effect of the gth brain region, and ei,j,kis an error term. The xi,j,k(sh) and xi,j,k(rg) are indicator variables set to 1 if the ijkth observation is from strain h and/or region g, respectively, and 0 otherwise. Note that we test only five strain and four region terms because of redundancy in adding the sixth strain and fifth region in the model.. Tests of significance of the strain and region effects involve the hypothesis that the relevant regression coefficient departs from 0.0. Tests of more global hypotheses of any strain and/or region effects can be constructed by fitting reduced models that do not include the strain (or region) terms and comparing these reduced models with the full model described above. These global tests involved five and four degrees of freedom for the strain and region effect tests, ...
A shallow slope of the exposure response relationship in the observable range in a laboratory bioassay predicts a higher low dose risk; a steep slope a lower low dose risk and thus allows a higher and less protective exposure limit. Increased variability in biological response of the host predicts a shallower exposure response relationship. BrooklynDodger hypothesizes that genetically diverse free living humans show greater variability than genetically homogeneous inbred laboratory housed animals. Therefore, a reference dose established with a dose response relationship in a laboratory study will be underestimate risk in people ...
Analysis of cerebral cortex from C57BL/6J and C3H/J strains at post-natal day 1 and week 11. These strains share similar collateral vessel anatomy but exhibit significantly different infarct volume. Results provide insight into molecular mechanisms modulating infarct volume ...
Analysis of cerebral cortex from C57BL/6J and C3H/J strains at post-natal day 1 and week 11. These strains share similar collateral vessel anatomy but exhibit significantly different infarct volume. Results provide insight into molecular mechanisms modulating infarct volume ...
The collaborative cross (CC) is a large panel of mouse-inbred lines derived from eight founder strains (NOD/ShiLtJ, NZO/HILtJ, A/J, C57BL/6J, 129S1/SvImJ,
The C166-GFP cell line was derived from the C166 cell line (ATCC CRL-2581) by transfection with a plasmid reporter vector, pEGFP-N1, encoding enhanced green fluorescent protein (GFP). The vector was obtained from Clontech, Palo Alto, CA (#6085-1). The C166 cell line was established from cells from F1 embryos obtained by mating a female NMRI/GSF mouse with a male CD-1 mouse that was transgenic for the human fes (fps/fes) proto-oncogene.
Susceptibility to tumor advancement varies among mice strains. is certainly dominant-resistant against NIH [1, 2]. A locus was mapped by examining the Car-R and Car-S crosses [13] also, which were produced by the well balanced intercross of eight inbred strains, including A/J, BALB/C, SJL/J, SWR/J, C57BL/6J, CBA/J, P/J and DBA/2 [9]. had been mapped with […]. ...
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Search for mouse SNPs represented in dbSNP by gene or genome region. Results include selected strains. Filter by dbSNP function class.
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So im interrested as im sure everyone is on how to get dense buds? Is it a strain dependant thing,a light thing or a fertalizer thing lol?I only have...
Learn all about mice, including the many different types of mice, facts about mice, the mouse anatomy, mouse life cycle, mouse identification, and many other mouse facts!
Grüneberg, H. (1954). "Variation Within Inbred Strains of Mice". Nature. 173 (4406): 674-676. Bibcode:1954Natur.173..674G. doi: ... Grüneberg, H.; Burnett, J. B.; Snell, G. D. (1941). "The Origin of Jerker, a New Gene Mutation of the House Mouse, and Linkage ... Most of his work focused on mouse genetics, in which his speciality was the study of pleiotropic effects of mutations on the ... The genetics of the mouse. 2nd ed, revised and enlarged. Nijhoff, The Hague. 1963. The pathology of development: a study of ...
Hemann, M. T. (2000-11-15). "Wild-derived inbred mouse strains have short telomeres". Nucleic Acids Research. 28 (22): 4474- ...
The sex-determining region of the human Y chromosome encodes a finger protein Genealogies of mouse inbred strains Mutations in ... Fisher, Elizabeth M. C. (2000). "Genealogies of mouse inbred strains". Nature. 24 (1): 23-25. doi:10.1038/71641. PMID 10615122 ... "Down's syndrome recreated in mice". 2005-09-22. Retrieved 2019-11-13. Professor Elizabeth Fisher - Mouse Models of Downs ... where she worked on mouse molecular genetics. At St Mary's Hospital, London Fisher completed microdissection on the mouse X ...
Stevens LC, Little CC (November 1954). "Spontaneous Testicular Teratomas in an Inbred Strain of Mice". Proceedings of the ... "Mutation frequency declines during spermatogenesis in young mice but increases in old mice". Proceedings of the National ... In the mouse, primordial germ cells (PGCs) arise in the posterior primitive streak of the embryo and start to migrate around ... In mice, PGCs originate from the proximal epiblast, close to the extra-embryonic ectoderm (ExE), of the post-implantation ...
MHC genes were first identified in inbred mice strains. Clarence Little transplanted tumors across differing strains and found ... George Snell selectively bred two mouse strains, attained a new strain nearly identical to one of the progenitor strains, but ... MHC molecules were identified and named after their role in transplant rejection between mice of different strains, though it ... To offset inbreeding, efforts to sustain genetic diversity in populations of endangered species and of captive animals have ...
"Wild-derived inbred mouse strains have short telomeres". Nucleic Acids Research. 28 (22): 4474-78. doi:10.1093/nar/28.22.4474. ... The studied mouse strains with decreased GH signalling showed between 20% and 68% increased longevity, and mouse strains with ... telomere length in wild mouse strains is unrelated to lifespan,[94] and mice lacking the enzyme telomerase do not have a ... The precise mechanism by which decreased GH/IGF-1 signalling increases longevity is unknown, but various mouse strains with ...
West, D. B.; Boozer, C. N.; Moody, D. L.; Atkinson, R. L. (1992-06-01). "Dietary obesity in nine inbred mouse strains". The ... In the strain of mice most commonly used for DIO models, C57BL/6J, mice who started the diet at 10 weeks old showed lower ... Furthermore, the strain and sex of the rodent impacts the response to the model. Some common mouse strains show large ... This has led to cases of studies that used the same strain of mice concluding that the strain is prone to becoming obese in one ...
314, 320, 326 Hemann MT, Greider CW (November 2000). "Wild-derived inbred mouse strains have short telomeres". Nucleic Acids ... The studied mouse strains with decreased GH signalling showed between 20% and 68% increased longevity, and mouse strains with ... However, telomere length in wild mouse strains is unrelated to lifespan, and mice lacking the enzyme telomerase do not have a ... The precise mechanism by which decreased GH/IGF-1 signalling increases longevity is unknown, but various mouse strains with ...
In mice, large differences in learning ability exist among different inbred strains. These differences appear to be correlated ... "Learning spatial orientation tasks in the radial-maze and structural variation in the hippocampus in inbred mice". Behavioral ... Behavioral Genetics of the Mouse. Cambridge Handbooks in Behavioral Genetics. 1. Cambridge: Cambridge University Press. pp. 299 ...
Laboratory mice, flies, fish, and worms are inbred through many generations to create strains with defined characteristics. ... Festing, M., "Inbred Strains of Mice and their Characteristics", The Jackson Laboratory . Retrieved 30 January 2008. Peichel CL ... the International Knockout Mouse Consortium, for example, aims to provide knockout mice for every gene in the mouse genome. In ... By one estimate the number of mice and rats used in the United States alone in 2001 was 80 million. Mice, rats, fish, ...
Rhodes, JS; Ford, MM; Yu, CH; Brown, LL; Finn, DA; Garland Jr, T; Crabbe, JC (2007). "Mouse inbred strain differences in ... Rhodes was one of the developers of the Drinking in the Dark model in mice. In this model, a specific mouse strain is found to ... Many drugs used to treat alcoholism in humans have been shown to lead to reduced ethanol consumption in mice used in this model ... Research from his lab has shown that adult and adolescent mice given equal amounts of cocaine display significant differences ...
Her first work in the lab helped to elucidate the sequence diversity of 20 inbred mouse strains based on substitutions, ... "Genetic and Haplotype Diversity Among Wild-Derived Mouse Inbred Strains". Genome Research. 14 (10a): 1880-1887. doi:10.1101/gr. ... Genetic and haplotype diversity among wild-derived mouse inbred strains. Genome Research, 2004 Oct;14:1880-1887. PMID 15466288 ... Her thesis worked explored the genetic architecture of DDK syndrome and the genetic basis for embryonic lethality in mice. She ...
Robinson SF, Marks MJ, Collins AC (April 1996). "Inbred mouse strains vary in oral self-selection of nicotine". ...
... learning in three inbred strains of mice". Brain Research. 785 (2): 236-244. doi:10.1016/S0006-8993(97)01417-0. PMID 9518631. ... "Inheritance of discrimination learning ability and retention in BA and DBA mice". Behavior Genetics. 11 (2): 173-177. doi: ...
Digit ratio (2D:4D) and behavioral differences between inbred mouse strains. Genes, Brain & Behavior 4: 318-323. Hurd PL, ... Intrauterine position effects on anogenital distance and digit ratio in male and female mice. Archives of Sexual Behavior (in ... while there is no difference in digit ratio between the sexes in most laboratory mice, that pups which gested next to brothers ...
Paylor R, Crawley JN (July 1997). "Inbred strain differences in prepulse inhibition of the mouse startle response". ... Possible hearing impairment must be taken into account, as, for example, several strains of mice develop high frequency hearing ... "Table 1: Mouse PPI pharmacology". from Geyer MA, McIlwain KL, Paylor R (2002). "Mouse genetic models for prepulse inhibition: ... While some of the hypotheses stand to the test, others are not, as some mice models show unchanged or increased PPI contrary to ...
Morici LA, Heang J, Tate T, Didier PJ, Roy CJ (2010). "Differential susceptibility of inbred mouse strains to Burkholderia ... B. thailandensis is sometimes used to model B. pseudomallei infection in mice because of similarities in the immune response. B ... Type strain of Burkholderia thailandensis at BacDive - the Bacterial Diversity Metadatabase v t e. ... 2007). "Inflammation patterns induced by different Burkholderia species in mice". Cell Microbiol. 10 (1): 81-87. doi:10.1111/j. ...
Effects of Aspiculuris tetraptera and Syphacia obvelata on exploratory behaviour of an inbred mouse strain. Laboratory Animal ...
Inbred strains are also available but are not as commonly used as inbred mice. ... is an inbred strain that spontaneously develops autoimmune type 1 diabetes. Like NOD mice, Biobreeding rats are used as an ... "Rules and Guidelines for Nomenclature of Mouse and Rat Strains". Mouse Genome Informatics. Jackson Laboratory. Retrieved 5 ... Index of Inbred Rat Strains database, Jacskson Laboratory. *Rat Model Summary database, Knock Out Rat Consortium (archived copy ...
"Variation and genetic control of gene expression in primary immunocytes across inbred mouse strains." J Immunol 193(9): 4485- ... Though most of the transcriptional profiling was done on B6 mice, the effect of genetic variation was also studied. The second ... As of August 2016, Immgen has profiled more than 250 naive cell populations in the mouse using microarrays, and several dozens ... for nearly all characterized cell populations of the adaptive and innate immune systems in the mouse, at major stages of ...
... unlike other model species like zebrafish and mice. By 1979, researchers had generated 10 inbred strains. These inbred lines ... Currently, 456 commercial strains are documented and available for fishkeeping. Medaka are not only kept as pets but also ... There are also many mutations that show up in medaka at random, for example, a mutant strain that lacks scales, and one with ... In 2014, work began on generating 111 different inbred lines derived from a single population collected in the wild. Medaka ...
Selective breeding - Organisms, often mice, may be bred selectively among inbred strains to create a recombinant congenic ... QTL mapping - The influence of a gene in some behavior can be statistically inferred by studying inbred strains of some species ... most commonly mice. The recent sequencing of the genome of many species, most notably mice, has facilitated this technique. ... This might be done to isolate an experimentally interesting stretch of DNA derived from one strain on the background genome of ...
1975). "Alpha fetoprotein: structure and expression in man and inbred mouse strains under normal conditions and liver injury". ... "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. Tomasi TB (1977). " ...
Schwartz WJ, Zimmerman P. Circadian timekeeping in BALB/c and C57BL/6 inbred mouse strains. J Neurosci. 1990; 10: 3685-3694. ...
... biochemical properties and variation in activity among inbred strains". Pharmacogenetics. 6 (1): 43-53. doi:10.1097/00008571- ... "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. Aksoy S, Brandriff ... Overexpression of SIRT1 in mice has been shown to reduce insulin and fasting glucose, as well as increased metabolism and ... 2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci ...
In 1999, they showed that different inbred strains of mice displayed very different pain sensitivity. Chief among these ... Responses of 11 inbred mouse strains on 12 measures of nociception". Pain. 80 (1): 67-82. doi:10.1016/s0304-3959(98)00197-3. ... "Genetic sensitivity to hot-plate nociception in DBA/2J and C57BL/6J inbred mouse strains: possible sex-specific mediation by δ2 ... female mice are more sensitive to itch than male mice; pain reduces sexual desire in male but not female mice; sex differences ...
"Sociability and preference for social novelty in five inbred strains: An approach to assess autistic-like behavior in mice". ... especially mice. Early in her career, she developed the light-dark mouse exploration test, and showed that it is a valid test ... "Baseline exploratory activity predicts anxiolytic responsiveness to diazepam in five mouse strains". Brain Research Bulletin. 8 ... What's wrong with my mouse: Behavioral phenotyping of transgenic and knockout mice, Wiley-Interscience, Hoboken, NJ (2007) 523 ...
"Sociability and preference for social novelty in five inbred strains: An approach to assess autistic-like behavior in mice". ... The journal has developed standards for the publication of mouse mutant studies. Many mouse mutant studies have serious ... Crusio WE, Goldowitz D, Holmes A, Wolfer D (February 2009). "Standards for the publication of mouse mutant studies". Genes, ... Crusio, Wim E. (2004). "Flanking gene and genetic background problems in genetically manipulated mice". Biological Psychiatry. ...
... of heroin-induced emotional dysfunction from psychomotor activation and physical dependence among inbred mouse strains." ... of heroin-induced emotional dysfunction from psychomotor activation and physical dependence among inbred mouse strains." ... In mice she has researched how the effects of heroin withdrawal can yield depressive behaviors. Her research has shown that ... She tested this theory of MOR association with depressive behavior and the results in mice lead to the conclusion that MOR and ...
Differences in Glo1 expression in mice appear to be caused by a copy number variant that is common among inbred strains of mice ... "Evaluating genetic markers and neurobiochemical analytes for fluoxetine response using a panel of mouse inbred strains". ... "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. Ranganathan S, ... April 2005). "Identification of glyoxalase-I as a protein marker in a mouse model of extremes in trait anxiety". The Journal of ...
Systematic inbreeding and maintenance of inbred strains of laboratory mice and rats is of great importance for biomedical ... In order to achieve a mouse strain that is considered inbred, a minimum of 20 sequential generations of sibling matings must ... 2006). "Selection and Inbreeding Depression: Effects of Inbreeding Rate and Inbreeding Environment". Evolution. 60 (5): 1014- ... "Inbred" redirects here. For the 2011 British film, see Inbred (film).. For reproduction by which offspring arise from a single ...
The wood lemming Myopus schisticolor, the Arctic lemming, Dicrostonyx torquatus, and multiple species in the grass mouse genus ... A sex-ratio theory for sex linkage and inbreeding has new implications in cytogenetics and entomology". Science. 156 (3774): ... List of Y-STR markers. *Muller's ratchet. *Single nucleotide polymorphism. *Y chromosome Short Tandem Repeat (STR) ... "Multiple origins of XY female mice (genus Akodon): phylogenetic and chromosomal evidence". Proceedings. Biological Sciences ...
But overdominance implies that yields on an inbred strain should decrease as inbred strains are selected for the performance of ... "Hybrid vigor and transgenerational epigenetic effects on early mouse embryo phenotype". Biol. Reprod. 79 (4): 638-48. doi ... Inbreeding depression is the loss of fitness due to loss of genetic diversity. Inbred strains tend to be homozygous for ... It attributes the poor performance of inbred strains to loss of genetic diversity, with the strains becoming purely homozygous ...
By identifying specific genetic markers for the genes of interest in a recombinant inbred strain, the amount of interaction ... Due to their low-maintenance and highly mapped genomes, mice, Drosophila,[19] and C. elegans[20] are very common. Zebrafish[21] ... researchers are able to use animal subjects such as mice and rats, but also fruit flies, worms, and zebrafish,[19][20] to try ... pose a greater challenge for QTL analysis because the genetic population cannot be as carefully controlled as that of an inbred ...
... several strains of mice (including BALB/c mice) and in three common monkey species.[4][5] ... "Antigenicity of carcinogen-induced and spontaneous tumours in inbred mice". British Journal of Cancer. 20 (4): 831-7. doi: ... in the mouse,[25] and by Hugh Pross and doctoral student Mikael Jondal in the human.[26][27] The mouse and human work was ... In both mice and humans, NKs can be seen to play a role in tumor immunosurveillance by directly inducing the death of tumor ...
... , the thale cress, mouse-ear cress or arabidopsis, is a small flowering plant native to Eurasia and Africa. ... Thousands of natural inbred accessions of A. thaliana have been collected from throughout its natural and introduced range.[15] ... Having specialized as a spring ephemeral, it has been used to found several laboratory strains that take about six weeks from ... syringae pv tomato strain DC3000. Recognition of avrRpt2 by RPS2 occurs via the guardee protein RIN4, which is cleaved . ...
Inbreeding depression[edit]. Inbreeding depression is the reduced fitness and survival of offspring from closely related ... Barriers are species specific; for example a river is a barrier to a field mouse, while a hawk can fly over a river. Corridors ... This stems from the fact that many microorganisms are not easily obtainable as cultured strains in the laboratory, which would ... And the inbreeding avoidance hypothesis suggests individuals disperse to decrease inbreeding. Studying these hypotheses can be ...
The P element is typically present only in wild strains, and not in lab strains of D. melanogaster, as the latter were ... The mouse t-allele is a classic example of a segregation distorter system that has been modeled in great detail.[49][120] ... A sex-ratio theory for sex linkage and inbreeding has new implications in cytogenetics and entomology". Science. 156 (3774): ... This is particularly a problem when breeders try to cross two different strains to create a new hybrid strain. One way to avoid ...
doi:10.1016/j.str.2018.10.022. PMID 30554841.. *^ a b Whittington CM, Papenfuss AT, Bansal P, Torres AM, Wong ES, Deakin JE, et ... "Activity of potent and selective host defense peptide mimetics in mouse models of oral candidiasis". Antimicrobial Agents and ... DLPs is involved in signalling to detect if self-pollination has occurred and induce self-incompatibility to prevent inbreeding ...
Typically, the seed company maintains two inbred varieties and crosses them into a hybrid strain that is then sold. Related ... One of these was isolated from an Agrobacterium strain CP4 (CP4 EPSPS) that was resistant to glyphosate.[123][124] The CP4 ... Many strains of corn have been developed in recent years to combat the spread of Maize dwarf mosaic virus, a costly virus that ... The strain lacks genes that encode proteins that repress defenses against the mildew. The researchers deleted all three copies ...
doi:10.1016/j.str.2008.11.008. PMID 19141283.. *^ Bowmaker JK (May 1998). "Evolution of colour vision in vertebrates". Eye. 12 ... Human and mouse somatic cells have a mutation rate more than ten times higher than the germline mutation rate for both species ... the maintenance of outcrossing sexual reproduction as opposed to inbreeding[70] and the evolution of sex and genetic ... In mice, the majority of mutations are caused by translesion synthesis.[49] Likewise, in yeast, Kunz et al.[50] found that more ...
The transfer of females or males from their native group is likely an adaptation for avoiding inbreeding.[103] An analysis of ... They range in typical size from Madame Berthe's mouse lemur, which weighs only 30 g (1 oz), to the eastern gorilla, weighing ... which are put under strain during chewing. Strepsirrhines have a postorbital bar, a bone around the eye socket, to protect ... A mouse lemur holds a cut piece of fruit in its hands and eats ... of inbred young is generally higher than that of non-inbred ...
The average litter size is 10-12 during optimum production, but is highly strain-dependent. As a general rule, inbred mice tend ... "Mouse Info". Retrieved 15 August 2016. Tembo, Mwizenge S. "Mice as a Delicacy: the Significance of Mice in the Diet of the ... The mouse genome has been sequenced, and virtually all mouse genes have human homologs. The mouse has approximately 2.7 billion ... However, certain strains have been known to be quite temperamental. Mice and rats have the same organs in the same places, with ...
The domesticated strain as was more uniform in its orientation, but the wild strains were larger and propagated faster. The ... variability can readily be lost by inbreeding, selection against undesired traits, or genetic drift, while in Drosophila, ... work was done on an attempted hybridization between an already domesticated grass strain, and several of its wild relatives. ...
In wild strains, a more fragile rachis allows the ear to easily shatter and disperse the spikelets.[15] Selection for these ... The standard method of breeding inbred wheat cultivars is by crossing two lines using hand emasculation, then selfing or ... CSIRO Rodent Management Research Focus: Mice plagues Archived 21 July 2010 at the Wayback Machine ... Cultivation and repeated harvesting and sowing of the grains of wild grasses led to the creation of domestic strains, as mutant ...
The transfer of females or males from their native group is likely an adaptation for avoiding inbreeding.[104] An analysis of ... A tiny mouse lemur holds a cut piece of fruit in its hands and eats ... which are put under strain during chewing. Strepsirrhines have a postorbital bar, a bone around the eye socket, to protect ... Charpentier MJ, Widdig A, Alberts SC (December 2007). "Inbreeding depression in non-human primates: a historical review of ...
... like an F2 or Recombinant inbred strains/lines (RILs). To scan for QTLs regions in a genome, a gene map based on linkage have ... As an example, consider groups of similar animals (mice, for example) under two different diet systems. The research question ... Sewall G. Wright developed F-statistics and methods of computing them and defined inbreeding coefficient. ... would be: what is the best diet? In this case, H0 would be that there is no difference between the two diets in mice metabolism ...
International Mouse Strain Resource. Organism supplier, Data repository Indeed. Job resource Immune Epitope Database and ... the Integrated Animal view combines data about experimental animal catalogs available to researchers from transgenic or inbred ... and Mouse Genome Informatics, the Connectivity view combines six databases that have statements about nervous system ... worms, zebrafish, mice and rats. We add more of these as data are registered, so check back to this page to see the current ...
... which showed outbreeding mice to exhibit MHC heterozygosity enhanced their health and survival rates against multiple-strain ... Charlesworth D, Willis JH (November 2009). "The genetics of inbreeding depression". Nat. Rev. Genet. 10 (11): 783-96. doi: ... mouse had less secretory diarrhea than normal, noncarrier mice. Thus, it appeared for a time that resistance to cholera ... A mouse model of CF was used to study resistance to cholera, and the results were published in Science in 1994 (Gabriel, et al ...
The uteroglobulin knockout mice on the inbred C57Bl6 strain develop Goodpasture's syndrome like glomerulopathy due to ... human genetic data might suggest that the effect may be indirect Uteroglobin knockout mice on the inbred 129 strain appear to ... "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine. Wolf M, Klug J, ... 2002). "In human IgA nephropathy uteroglobin does not play the role inferred from transgenic mice". Am. J. Kidney Dis. 40 (3): ...
Systematic inbreeding and maintenance of inbred strains of laboratory mice and rats is of great importance for biomedical ... In order to achieve a mouse strain that is considered inbred, a minimum of 20 sequential generations of sibling matings must ... The mice that are inbred typically show considerably lower survival rates. Inbreeding increases homozygosity, which can ... 2006). "Selection and Inbreeding Depression: Effects of Inbreeding Rate and Inbreeding Environment". Evolution. 60 (5): 1014- ...
Recombinant inbred strains or lines were first developed using inbred strains of mice but are now used to study a wide range of ... In the case of a typical mouse recombinant inbred strain made by crossing maternal strain BALB/cBy (C) with paternal strain ... pairs of the F2 progeny are then mated to establish inbred strains through long-term inbreeding. Families of recombinant inbred ... Between 2005 and 2007, virtually all extant mouse and rat recombinant inbred strains were regenotyped at many thousands of SNP ...
Inbred strains are also available, but are not as commonly used as inbred mice. Much of the genome of Rattus norvegicus has ... is an inbred strain that spontaneously develops autoimmune type 1 diabetes. Like NOD mice, biobreeding rats are used as an ... "Rules and Guidelines for Nomenclature of Mouse and Rat Strains". Mouse Genome Informatics. Jackson Laboratory. Retrieved 5 ... "Rat Genome", Nature Rat Genome Database, Medical College of Wisconsin Index of Inbred Rat Strains database, Jacskson Laboratory ...
"White Tigers Are All Inbred, Cross Eyed and Suffer Greatly". Big Cat Rescue. 25 November 2008. Retrieved 1 January 2020. Turner ... A similar condition is linked to Ornithine Transcarbamylase Deficiency in mice. Bicolor cat Calico cat Tortoiseshell cat Point ... Patched Tabbies and Calicos Archived 5 October 2011 at the Wayback Machine Strain, GM (2015). "The Genetics of Deafness in ...
4. Strains Made from Multiple Inbred Strains. 4.1 Recombinant Inbred Strains. 4.2 Collaborative Cross Strains. 4.3 Mixed Inbred ... 4.3 Mixed Inbred Strains. Incipient inbred stocks or inbred strains that are derived from up to three parental strains (one of ... 1.1 Mice. 1.2 Rats. 2. Laboratory codes. 3. Inbred Strains and Hybrids. 3.1 Definition 3.2 Nomenclature of Inbred Strains. 3.3 ... 5.2 Congenic Strains. 5.3 Chromosome Substitution or Consomic Strains. 5.3.1 Consomic Strains 5.4 Segregating Inbred Strains. ...
Inbred StrainsMice, Inbred StrainsMice, HairlessMice, Inbred AMice, Inbred AKRMice, Inbred BALB CMice, Inbred C3HMice, Inbred ... 129 StrainMice, HairlessMice, Inbred AMice, Inbred AKRMice, Inbred BALB CMice, Inbred C3HMice, Inbred C57BLMice, Inbred mdxMice ... Inbred mdxMice, Inbred CBAMice, Inbred CFTRMice, Inbred DBAMice, Inbred ICRMice, Inbred MRL lprMice, Inbred NODMice, Inbred NZB ... Inbred CBAMice, Inbred CFTRMice, Inbred DBAMice, Inbred ICRMice, Inbred MRL lprMice, Inbred NODMice, Inbred NZBMice, Inbred ...
FVB/N: an inbred mouse strain preferable for transgenic analyses.. M Taketo, A C Schroeder, L E Mobraaten, K B Gunning, G ... FVB/N: an inbred mouse strain preferable for transgenic analyses.. M Taketo, A C Schroeder, L E Mobraaten, K B Gunning, G ... FVB/N: an inbred mouse strain preferable for transgenic analyses.. M Taketo, A C Schroeder, L E Mobraaten, K B Gunning, G ... FVB/N mice offer a system suitable for most transgenic experiments and subsequent genetic analyses. The inbred FVB/N strain is ...
Effects of housing density in five inbred strains of mice.. Morgan JL1, Svenson KL1, Lake JP1, Zhang W1, Stearns TM1, Marion MA ... Five strains of mice (129S1/SvImJ, A/J, BALB/cByJ, C57BL/6J, and DBA/2J) were evaluated throughout 3- and 8-month timeframes ... Percent fat increased slightly in strains 129S1/SvImJ, A/J, and DBA/2J, but did not increase in strains BALB/cByJ, and C57BL/6J ... To evaluate the effect of increased mouse density in a cage, mice were housed at the density recommended by the 1996 Guide for ...
... in comparisons between inbred strains. We report a detailed analysis of polymorphism distribution in multiple inbred mouse ... in eight inbred strains.. We do not yet know whether claims for the utility of the mosaic structure of inbred strain sequences ... Unexpected complexity in the haplotypes of commonly used inbred strains of laboratory mice. B. Yalcin, J. Fullerton, S. Miller ... We report here the most detailed study to date of local polymorphism distribution in multiple inbred mouse strains. We analyzed ...
Strain-A offspring are nearly all affected; DBA-mice, about 75% affected; and C57BL-mice, about 20% affected. The strain-A ... CONGENITAL MALFORMATIONS INDUCED BY RIBOFLAVIN DEFICIENCY IN STRAINS OF INBRED MICE Message Subject (Your Name) has sent you a ... This may be discussed for two teratogens, in several inbred strains of mice, as an indication of the usefulness for elucidating ... CONGENITAL MALFORMATIONS INDUCED BY RIBOFLAVIN DEFICIENCY IN STRAINS OF INBRED MICE. Harold Kalter ...
The age-dependent change of the levels of five classes of immunoglobulin in mouse serum were investigated. Between 3 and 12 ... Quantitative estimations of five classes of immunoglobulin in inbred mouse strains Immunology. 1977 Jun;32(6):861-6. ... The age-dependent change of the levels of five classes of immunoglobulin in mouse serum were investigated. Between 3 and 12 ... Mice, Inbred C3H / immunology * Mice, Inbred C57BL / immunology * Mice, Inbred Strains / immunology* ...
The MSM/Ms inbred strain was established in 1986 and 21 years later it reached F100. During breeding, no significant ... We started to establish our unique strain, MSM/Ms, from MUS in Japan in 1978. In the beginning, we kept wild mice trapped in ... Most laboratory mice belong to a species of house mouse, Mus musculus. So far, at least three subspecies groups have been ... Genetic comparison between subspecies groups and common inbred strains (CIS) have revealed that the genetic background of CIS ...
Thus mice within an inbred strain are genetically identical, whereas mice from other inbred strains are genetically distinct ... STZ-induced diabetes in inbred mouse strains.. All strains of mice tested developed stable hyperglycemia 1 week after low-dose ... and GFR-in six commonly used inbred strains of mice.. RESEARCH DESIGN AND METHODS. The inbred male mice used in the present ... GFR in diabetic inbred mice.. GFR was serially examined in diabetic inbred mice and age-matched controls using FITC-inulin ...
... Behav Brain Res. 2008 Aug 5;191(1):118-29. doi: 10.1016/ ... for 10 inbred mouse strains of divergent genetic backgrounds. The present studies extend this multi-component behavioral ... of mice from these strains showing social avoidance. In the Morris water maze, NZB/B1NJ had a persistent bias for the quadrant ... In recent years, many genetic mouse models of autism and related disorders have been developed, based on candidate genes for ...
Inbred Strains" by people in Harvard Catalyst Profiles by year, and whether "Mice, Inbred Strains" was a major or minor topic ... "Mice, Inbred Strains" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Mice, Inbred Strains*Mice, Inbred Strains. *Mouse, Inbred Strain. *Inbred Strain of Mouse ... Below are the most recent publications written about "Mice, Inbred Strains" by people in Profiles. ...
... which is very extensive in mice, using an efficient mixed-model... ... We have developed an association-based approach using classical inbred strains of mice in which we correct for population ... Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits. ... Our approach includes inbred parental strains as well as recombinant inbred strains in order to capture loci with effect sizes ...
Mice from eight inbred strains were studied for their acute sensitivity to ethanol as indexed by the degree of hypothermia (HT ... Mice from eight inbred strains were studied for their acute sensitivity to ethanol as indexed by the degree of hypothermia (HT ... Acute tolerance chronic tolerance ethanol hypothermia inbred mouse strains loss of righting reflex pharmacogenetics ... McClearn G. E., and Rodgers D. A. (1959). Differences in alcohol preference among inbred strains of mice. Q. J. Stud. Alcohol ...
... Author(s). Mostafavi, Sara ... "Variation and Genetic Control of Gene Expression in Primary Immunocytes across Inbred Mouse Strains." The Journal of Immunology ... "Variation and Genetic Control of Gene Expression in Primary Immunocytes across Inbred Mouse Strains." The Journal of Immunology ...
Hemoglobin Solubility and α-Chain Structure in Crosses between Two Inbred Mouse Strains ... Hemoglobin Solubility and α-Chain Structure in Crosses between Two Inbred Mouse Strains ... Hemoglobin Solubility and α-Chain Structure in Crosses between Two Inbred Mouse Strains ... Hemoglobin Solubility and α-Chain Structure in Crosses between Two Inbred Mouse Strains ...
... is among the most versatile inbred mouse strains and the preferred genetic background for several applications. ... One of the most used inbred mouse models, the C57BL/6 is used in nearly every research application, and its commonly used as ... "The MRC Mary Lyon Centre located at MRC Harwell uses Taconics inbred mouse lines (specifically C57BL/6NTac) to generate and ... Popular strain for syngeneic tumor experiments; with a suite of related strains on the same background for mechanistic studies ...
... Journal. Mammalian Genome. ... Indeed, despite standardization and in line with previous studies, substantial variability among mice of the same inbred strain ... Together, these show that genetically inbred mouse strains consistently differ in phenotypic robustness against environmental ... whereas other strains ranked low (C57BL/6J and BALB/c). Strain rankings of within-strain variability in behavior were confirmed ...
Strain differences in behavioral inhibition in a Go/No-go task demonstrated using 15 inbred mouse strains. Alcohol Clin Exp Res ... Schimanski, L.A., Ali, D.W., Baker, G.B. & Nguyen, P.V. (2007) Impaired hippocampal LTP in inbred mouse strains can be rescued ... behavioural habituation to novelty and immediate early gene expression in two inbred mouse strains. Genes Brain Behav 9, 1-10. ... Social approach and repetitive behavior in eleven inbred mouse strains. Behav Brain Res 191, 118-129.. *CrossRef, ...
Festing MF: Origins and characteristics of inbred strains of mice. In Genetic Variants and Strains of the Laboratory Mouse. ... Recombinant inbred (RI) strains are derived by inbreeding different sets of F2 progeny from a cross between two inbred strains ... Male mice of parental (SM/J, A/J) strains, (SM/J × A/J)F1 mice, and 19 SMXA RI strains were obtained from The Institute for ... Belknap JK: Effect of within-strain sample size on QTL detection and mapping using recombinant inbred mouse strains. Behav ...
Mixtures, (50-50), of C57BL/6 and DBA/2 mouse leucocytes were cultured in medium containing low amounts of mouse plasma and ... Before harvest, the leucocytes were mobilized into the peripheral blood by a single intravenous injection of the mice with ... has been applied successfully to peripheral blood leucocytes of the mouse. ... Title : THE MIXED LEUCOCYTE REACTION APPLIED TO INBRED MOUSE STRAINS,. Corporate Author : NAVAL RADIOLOGICAL DEFENSE LAB SAN ...
... Bagot, S ... Comparisons of these strains to laboratory inbred strains confirmed a higher rate of polymorphism among the WDIS. We conclude ... Genetics, Malaria, genetic analysis, Plasmodium, wild derived inbred strains, loci, cerebral malaria, hyperparasitaemia., ... infection we analysed backcross and F2 cohorts derived from crossing the WLA wild-derived strain with a laboratory mouse strain ...
Strain-Specific Susceptibility for Pulmonary Metastasis of Sarcoma 180 Cells in Inbred Mice. Haris G. Vikis, Erin N. Jackson, ... BTBRT mice were injected i.p. with anti-CD4 and anti-CD8 antibodies or control normal goal IgG (250 μg/mouse, five animals per ... B, strain-dependent differences in CD4+ helper T cells at 1 d after delivery of S180-Fluc cells. C and D, induction of CD11b− ... A/J and BTBRT mice were injected with S180-Fluc cells or with media alone (n = 5 per group) and whole lungs were digested 1 d ...
mMSCs were obtained from 4 inbred strains of mice (Jackson Labs, Bar Harbor, ME): C57Bl/6J (Bl/6), BALB/c, FVB/N, and DBA1. In ... Adult stem cells from bone marrow (MSCs) isolated from different strains of inbred mice vary in surface epitopes, rates of ... We developed a protocol that provides rapidly expanding MSCs from 5 strains of inbred mice. The MSCs obtained from 5 different ... Plastic adherent stromal cells from the bone marrow of commonly used strains of inbred mice: variations in yield, growth, and ...
Worm burdens recovered from inbred mice strains, namely C57Bl/6, C57Bl/10, CBA, BALB/c, DBA/2 and C3H/He, conventionally ... Helminth Parasites of Conventionally Maintained Laboratory Mice - II- Inbred Strains with an Adaptation of the Anal Swab ... Based on our results, we can conclude that among the studied inbred strains, the CBA was that in which the mice were negative ... Except for this latter strain, A. tetraptera was found together S. obvelata in mice of the other studied strains. A. tetraptera ...
Mice. Inbred mouse strains were selected from the priority strains list of the Mouse Phenome Database (MPD: http://www.jax.org/ ... We report the characterisation of 27 cardiovascular-related traits in 23 inbred mouse strains. Mice were phenotyped either in ... Cardiovascular Response to Beta-Adrenergic Blockade or Activation in 23 Inbred Mouse Strains. Corinne Berthonneche,#1,2 Bastian ... A sequence-based variation map of 8.27 million SNPs in inbred mouse strains. Nature. 2007;448:1050-1053. 10.1038/nature06067. [ ...
The Effects of Ambient Temperature and Population Density On Aggression in Two Inbred Strains of Mice, Mus Musculus. in ... The Effects of Ambient Temperature and Population Density On Aggression in Two Inbred Strains of Mice, Mus Musculus. in ... I. 240 Male mice from the aggressive C57BL/I05 strain and non-aggressive A/J strain were subjected to temperatures of I8.3°C, ... 2. The mice were then crowded in groups of 8 into enclosures with floor areas of 0.09, 0.2I, or 0.38 m2. 3. The frequency of ...
Differential sensitivity to morphine-induced analgesia and motor activity in two inbred strains of mice: behavioral and ... Differential sensitivity to morphine-induced analgesia and motor activity in two inbred strains of mice: behavioral and ... Differential sensitivity to morphine-induced analgesia and motor activity in two inbred strains of mice: behavioral and ... Differential sensitivity to morphine-induced analgesia and motor activity in two inbred strains of mice: behavioral and ...
Mice, Inbred Strains. Fluorides -- Metabolism. Drug Resistance Abstract:. Fluoridation of community water supplies for the ... The genetic susceptibility/resistance to fluorosis among different inbred mouse strains. McHenry, Melissa A.K., 1971- ... The genetic susceptibility/resistance to fluorosis among different inbred mouse strains. Login ... Furthermore, we found clustering of strains into distinct phenotypic groups. The A/J mouse strain was highly susceptible, with ...
... and for inbred laboratory mouse strains C3H, LP/J and SJL. Sequence reads were grouped using a novel sequence clustering ... Various MLV subtypes were more widespread than expected among the mice, which may be due to the higher coverage of NGS, or to ... The inbred mouse strains C3H, LP/J and SJL were utilized because each strain exhibits multiple copies of gag leader sequences ... Mouse strains and MLV target regions. MLV was examined in laboratory mouse strains C3H, LP/J and SJL, and in two wild caught M ...
... inbred mouse strains by utilizing the eight founder strains of the Collaborative Cross and found a wild-derived strain, WSB/EiJ ... To identify genes involved in cerebral infarction we have employed a forward genetic approach in inbred mouse strains, using ... Novel Neuroprotective Loci Modulating Ischemic Stroke Volume in Wild-Derived Inbred Mouse Strains. ... WSB/EiJ and another wild-derived strain, CAST/EiJ, show the highest collateral vessel densities of any inbred strain, but ...
  • In experiments to generate transgenic mice, the same DNA constructs were injected into three different types of zygotes: FVB/N, C57BL/6J, and (C57BL/6J x SJL/J)F1. (pnas.org)
  • Percent fat increased slightly in strains 129S1/SvImJ, A/J, and DBA/2J, but did not increase in strains BALB/cByJ, and C57BL/6J. (nih.gov)
  • and C57BL-mice, about 20% affected. (aappublications.org)
  • First, it does not explain why cortisone regularly induces cleft palate in DBA-and C57BL-mice, which never have cleft lip and only extremely rarely have cleft palate, spontaneously. (aappublications.org)
  • the offspring of pregnant strain-A females fed galactoflavin only rarely have cleft palate, whereas offspring of treated DBA- and C57BL-females have moderately low to moderately high incidences of this anomaly. (aappublications.org)
  • The present studies characterized the severity of diabetic nephropathy in six inbred mouse strains including C57BL/6J, DBA/2J, FVB/NJ, MRL/MpJ, A/J, and KK/HlJ mice. (diabetesjournals.org)
  • DBA/2J and KK/HlJ mice developed significantly more albuminuria than C57BL/6J, MRL/MpJ, and A/J mice. (diabetesjournals.org)
  • DBA/2J and KK/HlJ mice are more prone to diabetic nephropathy, whereas the most widely used C57BL/6J mice are relatively resistant to development of diabetic nephropathy. (diabetesjournals.org)
  • One of the most used inbred mouse models, the C57BL/6 is used in nearly every research application, and it's commonly used as the genetic background for transgenic mouse models. (taconic.com)
  • Historical data shows that hydrocephaly occurs in the C57BL/6 mouse in 0.05% of the population and may not be evident until the animal is more than two months of age. (taconic.com)
  • Strikingly, across a multidimensional set of 115 behavioral parameters, several strains consistently ranked high in within-strain variability (DBA/2J, 129S1/Sv A/J and NOD/LtJ), whereas other strains ranked low (C57BL/6J and BALB/c). (uva.nl)
  • Mixtures, (50-50), of C57BL/6 and DBA/2 mouse leucocytes were cultured in medium containing low amounts of mouse plasma and supplemented with foetal bovine serum. (dtic.mil)
  • To study the genetic inheritance of resistant/susceptibility to P. berghei ANKA infection we analysed backcross and F2 cohorts derived from crossing the WLA wild-derived strain with a laboratory mouse strain (C57BL/6). (diva-portal.org)
  • mMSCs were obtained from 4 inbred strains of mice (Jackson Labs, Bar Harbor, ME): C57Bl/6J (Bl/6), BALB/c, FVB/N, and DBA1. (bloodjournal.org)
  • In addition, mMSCs were also obtained from the inbred transgenic strain C57Bl/6-TgN(ACTbEGFP)1Osb (GFPtg) that ubiquitously expressed enhanced green fluorescent protein (Jackson Labs). (bloodjournal.org)
  • Previously, besides the considered Swiss Webster mice, only two inbred strains (C57Bl/6, DBA/2) were investigated for the presence of helminths in Brazil (Pinto et al. (scielo.br)
  • The group B was represented by the strains C57Bl/6, CBA, BALB/c and C3H/He, with 25 mice each. (scielo.br)
  • In the study regarding the prevalence of species, the strains C57Bl/6, C57Bl/10 and C3H/He showed high percentages (88-96%) for A. tetraptera , whereas BALB/c, DBA/2 and C3H/He presented higher prevalence (80-100%) for S . obvelata , while the prevalence of V. nana was higher (92%) in the C3H/He strain. (scielo.br)
  • A. tetraptera was associated to V. nana in C57Bl/6, C57Bl/10 and C3H/He mice. (scielo.br)
  • I. 240 Male mice from the aggressive C57BL/I05 strain and non-aggressive A/J strain were subjected to temperatures of I8.3°C, 2I.I°C, 26.7°C, 32.2°C or 35°C for 24 hours. (brill.com)
  • To precisely quantify the influence of loading direction on stiffness and strength of femora loaded at the femoral head, we tested femora from C57BL/6 inbred mice. (uzh.ch)
  • We recently posited that genetic diversity in the immunoglobulin heavy chain (IGH) gene loci of C57BL/6 and BALB/c mice reflects differences in subspecies origin. (garvan.org.au)
  • By contrast, 83/84 inferred NOD IGHV genes had previously been observed in C57BL/6 mice. (garvan.org.au)
  • Very few IGHV sequences of C57BL/6 and BALB/c mice were shared with strains representing major subspecies, suggesting that their IGH loci may be complex mosaics of genes of disparate origins. (garvan.org.au)
  • Two inbred mouse strains, derived from feral founders, are susceptible to experimental leishmaniasis due to Leishmania major and support a disease of a severity intermediate between those observed in strains C57BL/6 and BALB/c. (asm.org)
  • Experimental infection of inbred BALB/c and C57BL/6 mice by L. major parasites constitutes one of the most studied models of parasitic disease ( 50 ). (asm.org)
  • Thus, resistant C57BL/6 mice infected with L. major develop a TH1 response resulting in gamma interferon (IFN-γ) production, macrophage activation, parasite killing, and resolution of the experimental lesion ( 19 , 36 , 55 ). (asm.org)
  • Recent work has demonstrated differences in femoral bone mineral density between two common inbred strains of mice, C3H/HeJ (C3H) and C57BL/6J (B6), across a wide age range. (galileo-training.com)
  • C57BL/6 and 129 inbred mouse strains differ in Gbp2 and Gbp2b expression in response to inflammatory stimuli in vivo. (crick.ac.uk)
  • C57BL/6 and 129 inbred mo. (crick.ac.uk)
  • Individual Gbp deletion strains differ in their design, as some strains exist on a pure C57BL/6 genetic background, while other strains contain a 129-derived genetic interval encompassing the Gbp gene cluster on an otherwise C57BL/6 genetic background. (crick.ac.uk)
  • Methods: To determine whether the presence of 129 alleles of paralogous Gbps could influence the phenotypes of 129-congenic Gbp-deficient strains, we studied the expression of Gbps in both C57BL/6J and 129/Sv mice following in vivo stimulation with adjuvants and after infection with either Toxoplasma gondii or Shigella flexneri. (crick.ac.uk)
  • Results: We show that C57BL/6J relative to 129/Sv mice display moderately elevated expression of Gbp2, but more prominently, are also defective for Gbp2b (formerly Gbp1) mRNA induction upon immune priming. (crick.ac.uk)
  • Conclusions: Our findings demonstrate functional differences between 129 and C57BL/6 Gbp alleles which need to be considered in the design and interpretation of studies utilizing mouse models, particularly for phenotypes influenced by Gbp2 or Gbp2b expression. (crick.ac.uk)
  • DBA/2J and C57BL/6J mice (n = 5-8 per observation) were evaluated in a time course experiment of IAV infection, focusing on early time points. (biomedcentral.com)
  • For instance, DBA/2J mice have been shown to be highly susceptible to the mouse-adapted IAV strain PR8 (A/Puerto Rico/8/1934 [H1N1]), whereas C57BL/6J mice are relatively resistant, as evidenced by less weight loss, less severe lung pathology, and a lower viral load. (biomedcentral.com)
  • We find that significant changes in hematological parameters are first detected 18 h post infection (hpi) in DBA/2J and by 24 hpi in C57BL/6J mice, and are fully manifest in both strains by 48 hpi. (biomedcentral.com)
  • Changes are consistently more pronounced in the more susceptible DBA/2J strain, whereas a procedure-related (mock treatment) effect, albeit mild, is observed in the C57BL/6J strain only. (biomedcentral.com)
  • The inflammatory reaction to latex particles and a saline-soluble extract of Listeria monocytogenes (SEL), expressed as the number of monocytes in the circulation and of macrophages at the site of inflammation, was about twice as strong in C57BL/10 mice compared with CBA mice. (rupress.org)
  • Evidence for the latter was provided by the finding that the intravenous injection of sera with FIM activity obtained from C57BL/10 and from CBA mice into the C57BL/10 mice evoked monocytosis, whereas CBA mice did not respond to these sera. (rupress.org)
  • Hair loss due to over-grooming (hair nibbling, whisker-eating) has been observed at The Jackson Laboratory for many years among mice in the C57BL/6J and related strains, i.e. (jax.org)
  • Mice of the C57BL substrains are much more prone to hair loss than other strains and certain congenic histocompatibility strains are especially susceptible. (jax.org)
  • At The Jackson Laboratory the type of alopecia resulting from social interaction of the mice - over-grooming - is considered a normal characteristic of C57BL/6J and related mouse strains and no attempt is made to prevent distribution of such mice. (jax.org)
  • In all experiments LORR duration and ethanol concentrations at return of righting reflex were measured after i.p. hypnotic ethanol doses and exposure to 22 or 34°C. In experiment 1, C57BL/6J, A/HeJ, 129/J, LS/Ibg and SS/Ibg mice were given 4.2 g/kg ethanol. (elsevier.com)
  • DBA/2J or D2) but not all (C57BL/6J or B6) inbred strains of mice, ethanol has a marked psychostimulant effect. (elsevier.com)
  • The AKR6 segment spanning the two substitutions, but not the entire AKR6 env -LTR, exists as an ERV, termed Xmv67 , in AKR, but not in the C57BL/6 mice. (mdpi.com)
  • In a major new initiative to enhance the power of the C57BL/6J-Chr# A /NaJ CS set, we are developing a set of germline-competent, embryonic stem cell lines from the individual strains. (jax.org)
  • A team of JAX researchers recently published "The Genome of C57BL/6J "Eve", the Mother of the Laboratory Mouse Genome Reference Strain", the female founder of the C57BL/6J (B6J) currently distributed by The Jackson Laboratory. (jax.org)
  • C57BL/6-aka Black 6-is the most widely used mouse strain in research. (jax.org)
  • In C57BL/6 mice, in vivo physiological responses to hyperinsulinemia at euglycemia and hypoglycemia were intermediate relative to other strains. (elsevier.com)
  • Insulin secretion by C57BL/6 mice was similar to that in other strains in contrast to the blunted glucose-stimulated insulin secretion from isolated islets. (elsevier.com)
  • The two inbred strains of mice C57BL/6 and DBA/2 are characterized by a different behavioral reactivity to cholinergic agents during development. (elsevier.com)
  • The results indicate that 1 or more genetic loci influence the value of tau DD, and a large (50 min) difference in mean tau DD between 2 of the strains, BALB/cByJ and C57BL/6J, allowed further characterization of the origins and inheritance of the polymorphic expression of this circadian pacemaker property. (umassmed.edu)
  • this discrepancy was significantly greater and more variable in BALB/c than in C57BL/6 mice, though the interstrain difference in mean tau DD could not be attributed entirely to this effect. (umassmed.edu)
  • Further study of inherited differences in the BALB/c and C57BL/6 strains may be a useful noninvasive experimental approach for investigation of the neurobiological substrates of circadian rhythmicity. (umassmed.edu)
  • DBA/2J and C57BL/6J mice were placed in cylindrical restrainers after injection of 3 g/kg (20% v/v) ethanol. (mendeley.com)
  • On the other hand, DBA/2J mice recovered at higher BEC than C57BL/6J animals. (mendeley.com)
  • By comparing a panel of inbred mouse strains, we recently identified a strain, 129S1/SvImJ (129S1), that exhibits a profound and selective deficit in Pavlovian fear extinction, and associated abnormalities in functional activation of a key prefrontal-amygdala circuit, as compared with C57BL/6J. (elsevier.com)
  • Results Approximately, 27.4M unique SNPs and 5M indels were identified across these strains compared to the C57BL/6J reference genome (GRCm38). (haldanessieve.org)
  • Here we describe differences in the cortical area map of two commonly used inbred strains of laboratory mice, C57BL/6J and DBA/2J. (beds.ac.uk)
  • The sample of C57BL/6J and DBA/2J mice can be discriminated with 90% accuracy on the basis of these three size dimensions. (beds.ac.uk)
  • C57BL/6J and DBA/2J have markedly different cortical area maps, suggesting that inbred strains harbor enough phenotypic variation to encourage a forward genetic approach to understanding cortical development, complementing other approaches. (beds.ac.uk)
  • Morphine elicits an increase of locomotor activity only in the C57BL/6J(C57) strain, whereas no effect is found when the opiate is injected to the DBA/2J mice (DBA). (unimi.it)
  • FACS analyses demonstrate that mouse NKG2D is expressed on all C57BL/6 IL-2-activated NK (lymphokine-activated killer (LAK)) cells, all splenic and liver NK cells, and ∼50% of splenic NKT cells. (jimmunol.org)
  • F1 offspring of TTA C57BL/6J and 129X1/SvJ, FVB/NJ, or DBA/1J showed improved spatial learning, but TTA expression caused subtle differences in contextual fear conditioning on two of these backgrounds, indicating that strain and genotype can interact independently under different behavioral settings. (jneurosci.org)
  • C57BL/6 inbred strains of mice are widely used in knockout and transgenic research. (frontiersin.org)
  • To investigate the behavioral characteristics of C57BL/6 substrains, we subjected C57BL/6J, C57BL/6N, and C57BL/6C mice to a behavior test battery. (frontiersin.org)
  • Of the many inbred strains, C57BL/6 is the most commonly used background strain for genetically engineered mice. (frontiersin.org)
  • The C57BL/6J was developed by Little in 1921, after crossing the female N.57 with the male N.52, and is the most widely used inbred strain. (frontiersin.org)
  • C57BL/6C mice were initially received from the National Cancer Institute of the NIH to the Institute of Medical Science, University of Tokyo, Japan in 1972. (frontiersin.org)
  • The segregation pattern of chromosomes 14 and 18 were analysed in recombinant inbred strains of mice developed from KE and CBA/Kw strains. (edu.pl)
  • It should be borne in mind that genetic drift means that there may still be unknown genetic differences between individuals within strains. (jax.org)
  • FVB/N mice offer a system suitable for most transgenic experiments and subsequent genetic analyses. (pnas.org)
  • Genetic markers of the FVB/N strain have been analyzed for 44 loci that cover 15 chromosomes and were compared with those of commonly used inbred strains. (pnas.org)
  • Genetic comparison between subspecies' groups and common inbred strains (CIS) have revealed that the genetic background of CIS is derived mainly from DOM. (go.jp)
  • This shows the importance of non-DOM wild mice as valuable genetic resources. (go.jp)
  • Extensive genetic analyses of chromosome C-banding pattern, biochemical markers and microsatellite DNA (MIT) markers of this strain have demonstrated the characteristics of MUS. (go.jp)
  • Inbred mice have been wildly used to model human diseases not only because they facilitate gene manipulation, but also because they share high genetic homology with humans ( 9 - 11 ). (diabetesjournals.org)
  • Many mouse models of diabetes have been established including type 1 diabetes due to streptozotocin (STZ) treatment and genetic models (e.g. (diabetesjournals.org)
  • In recent years, many genetic mouse models of autism and related disorders have been developed, based on candidate genes for disease susceptibility. (nih.gov)
  • We have previously reported profiles for sociability, preference for social novelty, and resistance to changes in a learned pattern of behavior, as well as other functional domains, for 10 inbred mouse strains of divergent genetic backgrounds. (nih.gov)
  • A natural mouse model reveals genetic determinants of systemic capillary leak syndrome (Clarkson disease). (harvard.edu)
  • In genetic crosses between mouse strains with low and high solubilities of hemoglobin, solubility segregated as a Mendelian unit and appeared to be determined by the alleles controlling α-chain structure. (sciencemag.org)
  • Together, these show that genetically inbred mouse strains consistently differ in phenotypic robustness against environmental variation, suggesting that genetic factors contribute to variation in robustness. (uva.nl)
  • Cohen, H. , Geva, A.B. , Matar, M.A. , Zohar, J. & Kaplan, Z. ( 2008 ) Post-traumatic stress behavioural responses in inbred mouse strains: can genetic predisposition explain phenotypic vulnerability? (wiley.com)
  • Recombinant inbred (RI) strains are a powerful tool for analyzing not only single genetic traits but also multifactorial genetic traits. (diabetesjournals.org)
  • For minimizing the variation of glucose tolerance in each strain, all mice were fed the high-carbohydrate diet and subjected to phenotypic and genetic analyses. (diabetesjournals.org)
  • Inbred strains are genetically homogeneous, and the genetic and environmental components can be strictly controlled in the experimental setting. (diabetesjournals.org)
  • The genetic analysis of a multifactorial disease in experimental animals such as mice and rats is much more revealing than that of a similar disease in human subjects. (diabetesjournals.org)
  • This thesis focuses on the genetic analysis of resistance to murine malaria induced by the lethal Plasmodium berghei ANKA using a wild-derived-inbred strain (WDIS). (diva-portal.org)
  • These features of mMSCs greatly limited the ability to test the cells in the large number of interesting genetic models that are now available as transgenic mice. (bloodjournal.org)
  • This indicates that cardiovascular phenotypes are unlikely to segregate according to global phylogeny, but rather be governed by smaller, local differences in the genetic architecture of the various strains. (pubmedcentralcanada.ca)
  • To identify genes involved in cerebral infarction we have employed a forward genetic approach in inbred mouse strains, using quantitative trait locus (QTL) mapping for cerebral infarct volume after middle cerebral artery occlusion. (fondationleducq.org)
  • The genetic background influences the responses of mineralized tissues to fluoride, such as dental fluorosis, observed in A/J and 129P3/J mice. (figshare.com)
  • The quality of the strain produced was assessed by the probability of an undetected region of heterozygosity (i.e., "gaps") in the recipient genetic background, while maintaining the desired donor-derived interval. (deepdyve.com)
  • Genetic structure of the LXS panel of recombinant inbred mouse strains: a powerful resource for. (deepdyve.com)
  • To characterize the genetic architecture of this new set of RI strains, we genotyped 330 MIT microsatellite markers distributed on all autosomes and the X Chromosome and assembled error-checked meiotic recombination maps that have an average F2-adjusted marker spacing of ∼4 cM. (deepdyve.com)
  • The LXS panel has a genetic structure consistent with random segregation and subsequent fixation of alleles, the expected 3-4 × map expansion, a low level of nonsyntenic association among loci, and complete independence among all 77 strains. (deepdyve.com)
  • To investigate this hypothesis, we conducted high-throughput sequencing of IGH gene rearrangements to document IGH variable (IGHV), joining (IGHJ) and diversity (IGHD) genes in four inbred wild-derived mouse strains (CAST/EiJ, LEWES/EiJ, MSM/MsJ and PWD/PhJ) and a single disease model strain (NOD/ShiLtJ), collectively representing genetic backgrounds of several major mouse subspecies. (garvan.org.au)
  • In order to obtain mice more suitable for genetic analyses of tumor susceptibility and tissue transplantation studies, several inbred lines of mice were derived from the SENCAR stock. (oup.com)
  • Focusing on genetic diversity in a mouse model of disease may be putting the cart before the horse in many cases. (uconn.edu)
  • Banbury Conference on Genetic Background in Mice (1997). (uconn.edu)
  • Mutant mice and neuroscience: recommendations concerning genetic background. (uconn.edu)
  • Mouse models, subjected to fewer nonheritable factors than humans, allow the identification of genetic factors that shape the immune system. (edu.au)
  • We characterized immunological trait variability in the Collaborative Cross (CC), a powerful genetic resource of recombinant inbred mouse strains derived from eight diverse founder strains. (edu.au)
  • Of the 18 immunological traits studied in more than 60 CC strains, eight showed genome-wide significant linkage, revealing new genetic loci linked to specific immune traits. (edu.au)
  • However, genetic association studies in inbred model organisms are confronted by the problem of complex population structure among strains. (genetics.org)
  • However, genetic association studies in inbred model organisms are confronted by the problem of inflated false positive rates due to population structure and genetic relatedness among inbred strains caused by the complex genealogical history of most model organism strains. (genetics.org)
  • Advances in genetic methods and the completed sequencing of the human and mouse genomes make it feasible to detect, genetically map and identify the genes underlying these complex disorders. (jax.org)
  • The SMSR is a resource of special strains of mice that are important tools for genetic analysis of such complex diseases. (jax.org)
  • CONCLUSIONS-Strain-dependent differences exist in four inbred mouse strains frequently used for genetic manipulation and study of glucose metabolism. (elsevier.com)
  • The existence of genetic differences raises the possibility that there exist, or can be developed, strains with extremely low or high levels of these peptides that would aid research directed at elucidating the physiology of opioid peptides. (elsevier.com)
  • We use two highly related strains (DBA/1J and DBA/2J) to investigate the genetic basis of collagen induced arthritis susceptibility. (haldanessieve.org)
  • We surveyed variation in miRNA abundance in the hippocampus of mouse inbred strains, allowing us to take a genetic approach to the study of miRNA regulation, which is novel for miRNAs. (essex.ac.uk)
  • The BXD recombinant inbred panel is a very well characterized genetic reference panel which allows quantitative trait locus (QTL) analysis of miRNA abundance and detection of correlates in a large store of brain and behavioural phenotypes. (essex.ac.uk)
  • In this chapter, we suggest that mouse models are useful for studying genetic background effects for acquired hearing loss. (intechopen.com)
  • The genetic analysis of mouse models identified the genetic modifiers. (intechopen.com)
  • We review the genetic research in mouse models for acquired hearing loss to identify and confirm the modifiers by both forward and reverse genetics approaches. (intechopen.com)
  • We discovered that the genetic strain background on which TTA is expressed dramatically influenced neurodegeneration caused by TTA protein. (jneurosci.org)
  • each same-sex animal is genetically identical to all others, and the individual differences among animals across strains derive from both genetic and environmental sources. (nap.edu)
  • When between-strain differences exceed within-strain variability, evidence for significant genetic influence is demonstrated. (nap.edu)
  • Because animal husbandry has begun to pay attention to the details of a mouse's genetic background, it is possible to study the same strains on the same behavioral tasks under multiple environmental conditions. (nap.edu)
  • Strain distribution patterns of microsatellite marker genotypes, weight, and other phenotypes are available on WebQTL (http://www.webqtl.org/search.html ) and allow genetic mapping of any heritable quantitative phenotype measured in these strains. (colorado.edu)
  • Large reference panels of RI strains, such as the LXS, are invaluable for identifying genetic correlations, GXE (Gene X Environment) interactions, and replicating previously identified QTLs. (colorado.edu)
  • However, the phenotypes of mutant mice are strongly influenced by genetic background, including flanking alleles, as well as the targeted genes. (frontiersin.org)
  • On behalf of the Committee for Standardised Genetic Nomenclature for Mice, nomenclature rules for naming mouse genes and mouse strains were published. (wikipedia.org)
  • The new maps ranged from a Mouse Chromosome Atlas that showed man-mouse homologies and correspondence between the genetic and G-band maps and replaced the previous linkage map, to maps of man-mouse homologies, cancer-related genes, the Genetic Imprinting map (http://mousebook.org), the chromosome aberration map, and a probe/clone map. (wikipedia.org)
  • In 1998 Mouse Genome, the official journal of the International Committee for Standardized Genetic Nomenclature for Mice, merged with Mammalian Genome the official journal of the International Mammalian Genome Society. (wikipedia.org)
  • Second, QTL mapping can be carried out by associating phenotypic variation in inbred strains with their strain distribution pattern (SDP) [ in silico mapping ( 8 )], where an SDP is the pattern of allelic similarities and differences among strains at a locus. (pnas.org)
  • We examined correlations of strain means to see whether patterns of strain differences were stable across time and across different test variants assessing the same behavioral construct. (springer.com)
  • The parental strains, SM/J and A/J, were nondiabetic, and the differences of the mean values of diabetes-related traits were small. (diabetesjournals.org)
  • In contrast, an impaired glucose tolerance was observed in (SM × A)F1 mice, and marked differences in diabetes-related traits were observed in 19 SMXA RI strains. (diabetesjournals.org)
  • B, strain-dependent differences in CD4+ helper T cells at 1 d after delivery of S180-Fluc cells. (aacrjournals.org)
  • The differences among MSCs from different strains may explain some of the conflicting data recently published on the engraftment of mouse MSCs or other bone marrow cells into nonhematopoietic tissues. (bloodjournal.org)
  • Results: Differences in dental fluorosis susceptibility/resistance were identified between the strains, ranging from mild, moderate, to severe dental fluorosis. (iupui.edu)
  • Similar body burden of fluoride, as judged from analysis of mineralized tissues, was seen in all strains despite differences in their predispositions to develop dental fluorosis. (iupui.edu)
  • In addition, we performed RNA sequencing for brain tissue of CAST/EiJ and WSB/EiJ mice and identified 79 candidate genes mapping in one of the four intervals showing strain-specific differences in expression. (fondationleducq.org)
  • The biological significance, the origin and the genetical causation of differences in behaviour between inbred strains of mice have been studied. (brillonline.com)
  • A comparison of the behaviour of these strains showed the presence of differences in all aspects of the behaviour studied. (brillonline.com)
  • Hematological differences between the strains were apparent even in untreated mice. (biomedcentral.com)
  • Differences in the response of inbred mouse strains to the factor increasing monocytopoiesis. (rupress.org)
  • Upstream haplotype differences between the parental strains suggested that 30-43% of differentially expressed genes were differentially expressed because of cis haplotype differences. (biomedcentral.com)
  • In order to understand the nature of the phenotypic differences between these two inbred lines we have characterized them using several parameters and markers that are associated with the progression of papillomas to squamous cell carcinoma (SCC). (oup.com)
  • Offsetting ethanol-induced hypothermia in five inbred strains of mice changed ethanol sensitivity within strains and markedly reduced differences between strains in brain sensitivity to hypnotic ethanol doses. (elsevier.com)
  • Despite the previous development of single-gene knock-out mice that exhibit alterations in aggressive behavior, very little progress has been made toward identifying the natural gene variants (alleles) that contribute to individual or strain differences in aggression. (jneurosci.org)
  • The mapping of these QTLs is a step toward the definitive identification of mouse alleles that affect aggression and may lead, ultimately, to the discovery of homologous alleles that affect individual differences in aggression within other mammalian species. (jneurosci.org)
  • Despite the success in creating single-gene mutations that affect mouse aggression, little progress has been made toward identifying the naturally occurring alleles that account for the differences in aggression among inbred mouse strains. (jneurosci.org)
  • OBJECTIVE-To characterize differences in whole-body glucose metabolism between commonly used inbred mouse strains. (elsevier.com)
  • The present experiment revealed that the strain-dependent differences in cholinergic-mediated analgesia during development disappeared during adult life. (elsevier.com)
  • Our data show differences in the emergence of recombination in both TCR α and β loci among strains. (ovid.com)
  • Circadian rhythms of locomotion (wheel-running activity) in 12 inbred mouse strains were recorded for interstrain differences in tau DD, the endogenous (free-running) period of the circadian pacemaker measured in constant environmental darkness. (umassmed.edu)
  • Inbred strains of laboratory mice can be exploited to study cortical area map formation if there are significant phenotypic differences with which to correlate gene polymorphism or expression data. (beds.ac.uk)
  • 6 ] have employed gene expression array analysis of the dissected embryonic (16.5d) mouse cerebral cortex to expand the list of genes regionally expressed, and noted that regional differences in expression of genes in the cortical plate should eventually convert into functionally distinct cortical areas with anatomically distinguishable borders after birth. (beds.ac.uk)
  • Over the last few years, we have typed the hybrid mouse diversity panel (HMDP) strains for a variety of clinical traits as well as intermediate phenotypes and have shown that the HMDP has sufficient power to map genes for highly complex traits with resolution that is in most cases less than a megabase. (springer.com)
  • The genomes of classical inbred mouse strains include genes derived from all three major subspecies of the house mouse, Mus musculus. (garvan.org.au)
  • To study the physiological functions of Gbp family members, the most commonly chosen in vivo models are mice harbouring loss-of-function mutations in either individual Gbp genes or the entire Gbp gene cluster on mouse chromosome 3. (crick.ac.uk)
  • DBA/2J mice also mount a hyper-inflammatory response with much stronger up-regulation of many immune response-dependent genes. (biomedcentral.com)
  • Few genes exhibited a significant strain-specific expression pattern, whereas a large number of genes exhibited brain region-specific patterns. (biomedcentral.com)
  • The trees based on the expression of strain-specific genes were constant across brain regions and mirrored DNA-level variation. (biomedcentral.com)
  • However, the trees based on region-specific genes exhibited a different set of strain relationships, depending on the brain region. (biomedcentral.com)
  • An eQTL analysis showed enrichment of cis -acting regulators among strain-specific genes, whereas brain region-specific genes appear to be mainly regulated by trans -acting elements. (biomedcentral.com)
  • In addition, we were interested in localizing regulatory elements of genes with either strain- or brain region-specific expression patterns by eQTL analyses. (biomedcentral.com)
  • We independently estimated from the congenic mice that 71-85% of genes were trans regulated. (biomedcentral.com)
  • Phenotypic correlation of some immune genes with male mice behaviors and brain morphology was analyzed in mouse phenome database (MPD) with the Pearson's method. (biomedcentral.com)
  • In view of the Tnfa gene location within the major histocompatibility (MHC) region and reports of its importance in disease protection activity, this paper examines the TNF a genes of a number of different mouse strains which were known to be of different disease response phenotypes. (cgiar.org)
  • Despite the limited power of inbred mouse association mapping due to the limited number of available inbred strains, we are able to identify significantly associated SNPs, which fall into known QTL or genes identified through previous studies while avoiding an inflation of false positives. (genetics.org)
  • Using these tests, and variants of them, investigators have clearly demonstrated that genes influence aggressive behavior in mice. (jneurosci.org)
  • Here we demonstrate that chemical mutagenesis of mice combined with advances in hematopoietic stem cell reagents and genome resources can efficiently recover recessive mutations and identify genes essential for generation and proliferation of definitive hematopoietic stem cells and/or their progeny. (bloodjournal.org)
  • The SMSR imports, cryopreserves and distributes RI and CS strain panels that are vital to discovery of quantitative trait loci (QTL) and ultimately genes responsible for complex diseases. (jax.org)
  • QTL and genes identified by QTL analysis in mouse models often correlate with homologous regions in the human genome. (jax.org)
  • Thus, connecting phenotype and genotype in mice may translate into identification of genes responsible for human complex diseases such as atherosclerosis, diabetes, obesity, asthma, autoimmunity and hypertension. (jax.org)
  • These ES cells will be useful for testing candidate genes in co-isogenic strain backgrounds, cellular phenotyping, and in vitro modeling of quantitative traits. (jax.org)
  • We studied the onset of the V(D)J recombination and transcription of the TCR Vα3 and Vβ11 genes during ontogeny in Balb-c, C57B1/6 and CBA inbred mouse strains. (ovid.com)
  • The extent to which mean strain responses on two tasks are correlated may be taken as an estimate of the degree to which a common set of genes influences both traits (Hegmann and Possidente 1981), and such a result would suggest the influence of common neurobiological mechanisms. (nap.edu)
  • Remarkable advances in molecular genetics have provided powerful tools to investigate the relationships between genes and behaviors in mice. (frontiersin.org)
  • These included lists and maps of mouse genes and mutants, information on inbred strains, and brief reports of useful results that did not merit a full paper. (wikipedia.org)
  • The first issue of the year was a "Maps" issue, the second issue was a "Genes" issue, the third issue was "Inbred Strains" and the fourth issue was a DNA probes and Restriction fragment length polymorphism issue. (wikipedia.org)
  • Three inbred strains with different origins were used, these were CPBs (Balb), CBA and C 57 Black. (brillonline.com)
  • However, neutralization of IL-4, which leads to a resistance phenotype in BALB/c mice, has no effect on disease progression in MAI mice. (asm.org)
  • In contrast, susceptible BALB/c mice mount a TH2 response and show macrophage deactivation leading to parasite dissemination and severe progressive disease ( 8 , 19 , 28 , 38 ). (asm.org)
  • The exquisite susceptibility of BALB/c mice to L. major infection has been ascribed to the occurrence, within the draining lymph nodes of these mice, of an early burst of interleukin 4 (IL-4), detectable at 16 h after parasite inoculation, which polarizes the immune response toward the TH2 pathway ( 20 , 21 , 32 ). (asm.org)
  • Considering this very particular mechanism of BALB/c mouse susceptibility to L. major infection, conclusions drawn from disease-modulating experiments with this mouse strain can hardly be extrapolated to human disease. (asm.org)
  • the BALB/c strain (with the shorter mean tau DD) displayed relatively fewer advance phase shifts. (umassmed.edu)
  • To characterize strain dependence of age-related changes in nociception and spinal expression of Ca v 2 in mice, we evaluated nociceptive sensitivity and Ca v 2α 1 mRNA expression in 2-month-old and 20-month-old mice of seven inbred strains (A/J, AKR/N, BALB/c, C3H/HeJ, C57BL6/J, DBA/2, 129/SvJ). (elsevier.com)
  • On the other hand bone growth in the DBA, A/J, Balb/C, and CBA/N strains were lower than in the others. (bvsalud.org)
  • The absolute value of bone weight in the SG was significantly smaller than that in the CG in six strains (NZB/N, C 57 BL, A/J, NZW/N, C 3 H/He, Balb/C) . However in the DBA strain , the absolute value of bone weight in the SG was significantly higher than that in the CG. (bvsalud.org)
  • [email protected]#To establish a suitable environment for the bioengineered teeth in vivo by observing the dentification ability of BALB/C mice tooth germs homologically implanted into the oral submucosa. (bvsalud.org)
  • METHODS @#The first molar tooth germs of BALB/C mice 4 days after birth were transplanted into the oral submucosa of BALB/C male mice , and then recycled for regular histological observation after 1, 2, 3, and 6 week transplantation . (bvsalud.org)
  • [email protected]#The environment of the BALB/C male mice oral submucosa is favorable for the growth of tooth germs in inbred strain BALB/C mice , and it can provide a new environment for the development of bioengineered teeth in vivo. (bvsalud.org)
  • Furthermore, it has been suggested that allelic strain distribution patterns also occur in well defined blocks and consequently could be used to map quantitative trait loci (QTL) in comparisons between inbred strains. (pnas.org)
  • However, sampling has so far been carried out at a low density: Wiltshire and colleagues ( 3 ) sequenced 2,600 evenly distributed loci at intervals of ≈1.1 megabases (Mb) in eight inbred strains. (pnas.org)
  • Our approach includes inbred parental strains as well as recombinant inbred strains in order to capture loci with effect sizes typical of complex traits in mice (in the range of 5 % of total trait variance). (springer.com)
  • Identification of two cerebral malaria resistance loci using an inbred wild-derived mouse strain. (diva-portal.org)
  • Various MLV subtypes were more widespread than expected among the mice, which may be due to the higher coverage of NGS, or to the presence of similar sequence across many different proviral loci. (biomedcentral.com)
  • QTL mapping between these strains identified four new neuroprotective loci modulating cerebral infarct volume while not affecting collateral vessel phenotypes. (fondationleducq.org)
  • Speed, Terence 2006-04-04 00:00:00 The development of congenic mouse strains is the principal approach for confirming and fine mapping quantitative trait loci, as well as for comparing the phenotypic effect of a transgene or gene-targeted disruption between different inbred mouse strains. (deepdyve.com)
  • This suggests a similar level of diversity is likely present in the IGH loci of other classical inbred strains. (garvan.org.au)
  • I recently heard Howard Jacob (Medical College of Wisconsin) give a talk in which he showed that in Sprague Dawley rats ~one-third of the genome was fully inbred, and the average number of alleles for most loci was only 2(whereas in a panel of 48 different inbred strains, the total available diversity averaged around 6 alleles/locus). (uconn.edu)
  • Intercrosses formed from the D2 and B6 strains have been used to detect quantitative trait loci (QTLs) for this phenotype. (elsevier.com)
  • The transcriptions of these loci followed respective recombinations and we detected an early germline transcript before TCR β locus recombination in the CBA strain. (ovid.com)
  • Most laboratory mice have contributions from both Mus musculus musculus and Mus musculus domesticus . (jax.org)
  • Studies of sequence variation between inbred strains of laboratory mice suggest that the distribution of polymorphisms has a mosaic structure of alternating segments of high and low frequency ( 1 - 3 ), consistent with descent of the most commonly used strains from a few subspecies, such as Mus musculus musculus ( 4 ). (pnas.org)
  • Most laboratory mice belong to a species of house mouse, Mus musculus . (go.jp)
  • Two hundred and fifty Mus musculus (Linnaeus, 1758) inbred mice from two animal houses in the State of Rio de Janeiro, RJ, Brazil, were divided in two groups (A, B) according to their source. (scielo.br)
  • Next generation sequencing (NGS) data was generated for MLVs from two wild caught Mus musculus domesticus (from mainland France and Corsica) and for inbred laboratory mouse strains C3H, LP/J and SJL. (biomedcentral.com)
  • Murine leukemia viruses (MLVs) are present in the germ line of the house mouse Mus musculus and of related species as endogenous retroviruses [ 1 ]. (biomedcentral.com)
  • In our analysis of NGS-generated data, we overcome these challenges by using a clustering approach to determine the distribution of MLVs in two wild-caught and three inbred laboratory strains of M. musculus . (biomedcentral.com)
  • We have reconstructed the origin and history of a 127-kbp segmental duplication, R2d , in the house mouse ( Mus musculus ). (genetics.org)
  • Mice from eight inbred strains were studied for their acute sensitivity to ethanol as indexed by the degree of hypothermia (HT), indexed as the reduction from pre-injection baseline of their body temperature. (springer.com)
  • Mice of the eight inbred strains differing in their susceptibility to radiation-induced pulmonary fibrosis, and in the duration of asymptomatic survival, received 18 Gy whole thorax irradiation and were killed 6 h, 24 h, or 7 days later. (physiology.org)
  • Mouse strain names should be registered through the Mouse Genome Database (MGD) at http://www.informatics.jax.org/mgihome/submissions/amsp_submission.cgi . (jax.org)
  • Rat strain names should be registered through the Rat Genome Database (RGD) at http://rgd.mcw.edu/tools/strains/strainRegistrationIndex.cgi . (jax.org)
  • The apparent mosaic structure of the mouse genome can be exploited for QTL mapping in two ways. (pnas.org)
  • The approach is identical to the exploitation of haplotype blocks (regions of complete or almost complete linkage disequilibrium) in the human genome for association mapping ( 9 ) but requires a different analysis to take advantage of the small number of founder animals from which laboratory strains are descended. (pnas.org)
  • If the genome is sequenced so that each nucleotide position is covered with good-quality sequence x times on average, then the probability that a polymorphism is not covered in one strain will be e - x , assuming a Poisson distribution. (pnas.org)
  • Although 71,000 SNPs were analyzed, just 7.8% of the genome was covered in all strains ( x = 1.3 and n = 8 gives 0.727 8 ). (pnas.org)
  • We further find that the higher expression of Gbp2b mRNA in 129/Sv mice correlates with a gene duplication event at the Gbp2b locus resulting in two copies of the Gbp2b gene on the haploid genome of the 129/Sv strain. (crick.ac.uk)
  • Recent genome sequencing efforts have catalogued DNA-level variation between different species, strains, and individuals. (biomedcentral.com)
  • Prkdc participates in mitochondrial genome maintenance and prevents Adriamycin-induced nephropathy in mice. (rush.edu)
  • Source: Mouse Genome Informatics email list. (uconn.edu)
  • We applied EMMA to in silico whole-genome association mapping of inbred mouse strains involving hundreds of thousands of SNPs, in addition to Arabidopsis and maize data sets. (genetics.org)
  • Here, we performed a genome-wide association study of female infertility in 25 inbred mouse strains by using publicly available SNP data. (g3journal.org)
  • Because all mice from an inbred strain are genetically identical and homozygous, these databases in conjunction with phenotypic information on corresponding strains open the opportunity for genome-wide association mapping of quantitative traits in an easy and cost-effective way ( Flint and Eskin 2012 ). (g3journal.org)
  • Centralized Mouse Repositories, Mammalian Genome 23(9-10):559-71. (jax.org)
  • The amount of variation found in the inbred laboratory mouse genome has increased to 71M SNPs and 12M indels. (haldanessieve.org)
  • In 1990 Mouse News Letter changed its name to Mouse Genome which merged with the journal Mammalian Genome in 1998. (wikipedia.org)
  • In February 1990 Mouse News Letter changed its name to Mouse Genome. (wikipedia.org)
  • Starting in 1991 Mouse Genome was published four times a year as one volume with four issues. (wikipedia.org)
  • The merged journal kept the name Mammalian Genome and includes the words "Incorporating Mouse Genome" on its front cover. (wikipedia.org)
  • Effects of housing density in five inbred strains of mice. (nih.gov)
  • Because of the wealth of data accumulated, we applied integrative analyses such as comprehensive bi-clustering to investigate the structure of the response across the different phenotypes, strains and experimental conditions. (pubmedcentralcanada.ca)
  • Finally, we observe little concordance between strain similarity based on the phenotypes and genotypic relatedness computed from genomic SNP profiles. (pubmedcentralcanada.ca)
  • RESULTS-Insulin action and hypoglycemic counter-regulatory and insulin secretory phenotypes varied considerably in four inbred mouse strains. (elsevier.com)
  • We now have several examples of fully sequenced closely related strains that are divergent for several disease phenotypes. (haldanessieve.org)
  • Conclusion This paper significantly expands the catalog of fully sequenced laboratory mouse strains and now contains several examples of highly genetically similar strains with divergent phenotypes. (haldanessieve.org)
  • Investigation of sequence variation in common inbred mouse strains has revealed a segmented pattern in which regions of high and low variant density are intermixed. (pnas.org)
  • Moran MM, Virdi AS, Sena K, Mazzone SR, McNulty MA, Sumner DR. Intramembranous bone regeneration differs among common inbred mouse strains following marrow ablation. (rush.edu)
  • We report a detailed analysis of polymorphism distribution in multiple inbred mouse strains over a 4.8-megabase region containing a QTL influencing anxiety. (pnas.org)
  • Because of the importance and potential power of eQTL studies in identifying regulatory networks, we analyzed gene expression patterns in different brain regions from multiple inbred mouse strains and investigated the implications for the design and analysis of eQTL studies. (biomedcentral.com)
  • Differential susceptibility to diabetic nephropathy has been observed in humans, but it has not been well defined in inbred strains of mice. (diabetesjournals.org)
  • Taken together, these results indicate that differential susceptibility to diabetic nephropathy exists in inbred mice. (diabetesjournals.org)
  • Analysis of two inbred strains of mice derived from the SENCAR stock with different susceptibility to skin tumor progression. (oup.com)
  • One of these lines, the SSIN mice, has a higher susceptibility to tumor. (oup.com)
  • One of these lines, the SSIN mice, has a higher susceptibility to tumor promotion compared to the SENCAR stock but is very resistant to tumor progression. (oup.com)
  • On the other hand, the SENCAR B/Pt mice, derived also from the outbred stock, not only have a tumor promotion susceptibility almost identical to the SSIN mice, but they also have a high susceptibility to tumor progression. (oup.com)
  • FVB is an albino, inbred laboratory mouse strain that is named after its susceptibility to Friend leukemia virus B. This strain was produced from mice established at the National Institutes of Health in 1935. (wikipedia.org)
  • These mice have greater susceptibility to an asthma-like phenotype than wild-type animals. (wikipedia.org)
  • Within-strain variation in behavior differs consistently between common inbred strains of mice. (uva.nl)
  • Here, we compared robustness between cohorts of isogenic mice of eight different commonly used strains by analyzing to what extent environmental variation contributed to individuality in each of the eight genotypes, using a previously published dataset. (uva.nl)
  • In this study, we expanded the pool of allelic variation among classical inbred mouse strains by utilizing the eight founder strains of the Collaborative Cross and found a wild-derived strain, WSB/EiJ, that breaks this general rule that collateral vessel density inversely correlates with infarct volume. (fondationleducq.org)
  • We believe that inbred mouse strains offer an excellent model to study the relationship between DNA-level variation and variation in gene expression patterns, because the genealogy and DNA-level variation across different strains are well known. (biomedcentral.com)
  • We considered how global DNA-level variation correlates with gene expression pattern variation across five brain regions in six inbred mouse strains. (biomedcentral.com)
  • However, these studies are limited by the variation present in the parental strains and have long regions between recombinations due to relatively few generations between the recombinant inbred strains and the parental strains. (genetics.org)
  • In the present study, we analyzed the degree of phenotypic variation in female infertility across 25 inbred mouse strains. (g3journal.org)
  • SNP variation data for RI strains and gene expression data for the ILSXISS RI set are also available at Mouse Phenome Database. (jax.org)
  • In 2011, the initial analysis of sequence variation across 17 strains found 56.7M unique SNPs and 8.8M indels. (haldanessieve.org)
  • If single-nucleotide polymorphisms (SNPs) are randomly distributed across the genomes of inbred strains, mapping QTL by SDP association with phenotype will require a very dense set of markers, but if the distribution is segmented, then a few markers will be sufficient to identify common haplotypes. (pnas.org)
  • Overall, this set of tasks and observational methods provides a strategy for evaluating novel mouse models in behavioral domains relevant to the autism phenotype. (nih.gov)
  • The aim of this study was to investigate the effects of NTX on two measures of impulsive behaviour in two inbred mouse strains that differ in ethanol preference and impulsive phenotype. (sussex.ac.uk)
  • Thus, H-FSS mice showed increased basal noradrenaline tissue levels compatible with a fear phenotype or chronic stressed condition. (elsevier.com)
  • Quantitative trait analysis of B6C3 F2 TTA mice identified a region on Chromosome 14 that contains a major modifier of the neurodegenerative phenotype. (jneurosci.org)
  • Substrains should be identified by Laboratory codes, as should congenic and other strains where several different forms exist that are not otherwise distinguishable. (jax.org)
  • The earlier tests used some of the exact substrains tested currently, while for some strains, different substrains (usually, Nih versus Jax) were tested. (springer.com)
  • The behaviour of each strain was strain specific as appeared from a comparison with earlier reports on related substrains. (brillonline.com)
  • We have developed an association-based approach using classical inbred strains of mice in which we correct for population structure, which is very extensive in mice, using an efficient mixed-model algorithm. (springer.com)
  • Our analysis indicates that it is only partly true that the genomes of inbred strains exist as a patchwork of segments of sequence identity and difference. (pnas.org)
  • Background The Mouse Genomes Project is an ongoing collaborative effort to sequence the genomes of the common laboratory mouse strains. (haldanessieve.org)
  • Casci T (2012) Mouse genetics: fruits of the Collaborative Cross. (springer.com)
  • Purpose: To assess the role of genetics in the pathogenesis of dental fluorosis using genetically separate inbred strains of mice. (iupui.edu)
  • With my limited knowledge in genetics, I understand that the ICR results are more or less expected because of diversity in gene functions in individual outbred mice (could anyone expand on this topic in terms of mouse genetics? (uconn.edu)
  • One of the simplest meaningful behavior genetics experiments with mice is to compare multiple inbred strains on the same task. (nap.edu)
  • Genetics of body weight in the LXS recombinant inbred mouse strains. (colorado.edu)
  • We are taking advantage of our unique access to patient biospecimens and our cutting-edge mouse genetics to dissect how tumors subvert immune surveillance by changing their metabolic profile. (nyu.edu)
  • Mouse News Letter (MNL) was a bulletin of mouse genetics information published from 1949 to 1998. (wikipedia.org)
  • Mouse News Letter now exists as a company, Mouse News Letter Ltd, which promotes the science of Genetics and provides funds to enable younger scientists to attend Genetics Conferences. (wikipedia.org)
  • To survey the history of the Mouse News Letter is to see the history of mouse genetics unfold. (wikipedia.org)
  • At the Eighth International Genetics Congress in 1948 eminent geneticists Douglas Falconer, R.A.Fisher, Salome Gluecksohn-Waelsch, Hans Grüneberg and Paula Hertwig agreed that investigators working on mouse genetics and development needed a regular information bulletin. (wikipedia.org)
  • During the 1990s it became clear with the exponential increase in knowledge that the long-term future of mouse genetics information was an electronic one. (wikipedia.org)
  • Whereas most laboratory strains were susceptible to experimental cerebral malaria (ECM) after infection with P. berghei ANKA, several WDIS were found to be resistant. (diva-portal.org)
  • Using quantitative RT-PCR, we found that Sorbs1 is highly expressed in the mouse uterus during embryo implantation. (g3journal.org)
  • Strains also have been found to differ in the new LRR test, as well as in the development of acute functional tolerance (AFT) to this response. (springer.com)
  • The hematological response to infection may differ significantly among inbred mouse strains. (biomedcentral.com)
  • These findings suggest that age-related changes in nociceptive transmission differ in different strains, and may be associated with impairment of spinal synaptic neurotransmission owing to deterioration of depolarization-induced Ca 2+ currents caused by age-related Ca v 2.1 or Ca v 2.2 channel dysfunction. (elsevier.com)
  • For example, Krubitzer and Kahn [ 1 ] review that the mouse, ghost bat, and short-tailed opossum have approximately the same size cortical sheet, but differ substantially in the size of one of three primary sensory cortical areas. (beds.ac.uk)
  • Stress-induced changes in plasma corticosterone and central monoamine levels were examined in mouse strains that differ in fear-related behaviors. (elsevier.com)
  • In addition, some recently developed laboratory mouse strains are derived wholly from other Mus species or other subspecies, such as M. spretus ). (jax.org)
  • In addition to the albino FVB/N strain, pigmented congenic strains of FVB/N are being constructed. (pnas.org)
  • The traditional breeding scheme calls for at least nine consecutive backcrosses before establishing a congenic mouse strain. (deepdyve.com)
  • We used simulation studies to investigate the efficiency of different marker-assisted breeding schemes by examining the trade-off between the number of backcrosses, the number of mice produced per generation, and the number of genotypes per mouse required to achieve a quality congenic mouse strain. (deepdyve.com)
  • Somewhat surprisingly, we found that there is a relatively high probability for undetected gaps in potential breeders for establishing a congenic mouse strain. (deepdyve.com)
  • Marker-assisted breeding may decrease the number of backcross generations required to generate a congenic strain, but only additional backcrossing will guarantee a reduction in the number and length of undetected gaps harboring contaminating donor alleles. (deepdyve.com)
  • To quantify cis and trans regulation we correlated haplotype data with gene expression in two inbred mouse strains and two derived congenic lines. (biomedcentral.com)
  • For example, the cholesterol synthesis pathway was strongly differentially expressed in the congenic mice by indirect trans regulation but this was not observable in the parental mice. (biomedcentral.com)
  • This guideline is reviewed annually by the international nomenclature committees for mouse and rat and updated as required. (jax.org)
  • Reference to former rules for rat strain nomenclature can be found in Committee on Rat Nomenclature (1992). (jax.org)
  • Production of inbred strains means that these backgrounds can be defined and thus require nomenclature conventions. (jax.org)
  • A key feature of mouse and rat nomenclature is the Laboratory Registration Code or Laboratory code, which is a code of usually three to four letters (first letter uppercase, followed by all lowercase) that identifies a particular institute, laboratory, or investigator that produced, and may hold stocks of, a mouse or rat strain. (jax.org)
  • Thus, the present findings ratify those reported for these strains, as well as complement the evaluation of worm burden in the other commonly referred inbred mice. (scielo.br)
  • Wasserman, David H. / Glucose metabolism in vivo in four commonly used inbred mouse strains . (elsevier.com)
  • We also found that TTA expression can affect cognitive performance in several commonly used behavioral tasks, again in a strain-dependent manner. (jneurosci.org)
  • Some of these alleles have avoided selection during breeding as either fancy mice or laboratory mice. (go.jp)
  • In inbred mouse strains, seven Hh-1 alleles representing combinations of five different Hh-1 antigenic determinants are described. (elsevier.com)
  • The full name of this strain is FVB.129P2-Pde6b+ Tyrc-ch/AntJ, reflecting its genotype. (wikipedia.org)
  • This may be discussed for two teratogens, in several inbred strains of mice, as an indication of the usefulness for elucidating some theoretic points to which it can be put. (aappublications.org)
  • The present studies extend this multi-component behavioral characterization to several additional strains: C58/J, NOD/LtJ, NZB/B1NJ, PL/J, SJL/J, SWR/J, and the wild-derived PERA/EiJ. (nih.gov)
  • 2014. Derivation and characterization of mouse embryonic stem cells (mESCs) from permissive and non-permissive strains. (jax.org)
  • In addition to making these highly valuable RI and CS strains available to the scientific community, we are enhancing the value of these models through additional characterization and curation. (jax.org)
  • Therefore, they should not be referred to by species name, but rather as laboratory mice or by use of a specific strain or stock name. (jax.org)
  • Laboratory rat strains derive from the Rattus norvegicus species. (jax.org)
  • Another species, Rattus rattus , also is used as an experimental model, but has not contributed to the common laboratory rat strains. (jax.org)
  • Female and male mice 8 to 10 weeks old were used, and they were individually killed by CO 2 . (bloodjournal.org)
  • confounding variables, and male mice happen to be less valuable. (bio.net)
  • An Automated Method To Predict Mouse Gene and Protein Sequences Using Variant Data. (harvard.edu)
  • Gene expression profiles of five brain regions in six inbred mouse strains were studied. (biomedcentral.com)
  • We investigated whether inbred strains that are closely related have gene expression profiles that on average resemble each other more than strains that are distantly related. (biomedcentral.com)
  • Knockdown of Sorbs1 by siRNA attenuates the induction of differentiation marker gene Prl8a2 (decidual prolactin-related protein) in an in vitro model of decidualization using mouse endometrial stromal cells, suggesting that Sorbs1 may be a potential candidate gene for female infertility in mice. (g3journal.org)
  • In gene technology, low-virulence strains of adenovirus are used as vectors in gene transfer. (helmholtz-hzi.de)
  • In addition to albinism and Friend leukemia virus sensitivity, these mice become blind by weaning age due to being homozygous for a retinal deterioration allele on the PDE6B gene. (wikipedia.org)
  • In particular, several SMXA RI strains showed markedly impaired glucose tolerance and hyperglycemia. (diabetesjournals.org)
  • The 129P3/J mouse strain was least affected with negligible dental fluorosis. (iupui.edu)
  • The aim of the present study was to map the protein profile of enamel matrix from A/J and 129P3/J strains. (figshare.com)
  • Enamel matrix samples were obtained from A/J and 129P3/J mice and analyzed by 2-dimensional electrophoresis and liquid chromatography coupled with mass spectrometry. (figshare.com)
  • 0.7) and significant correlations of trait values measured in baseline condition with independent multistrain datasets of the Mouse Phenome Database. (pubmedcentralcanada.ca)
  • Phenotypic data were obtained from the Mouse Phenome Database at Jackson Laboratory ( http://phenome.jax.org/ ). (g3journal.org)
  • These data are available from the Mouse Phenome Database (MPD) website. (jax.org)
  • Here, to test for a possible mechanistic contribution of eCBs to fluoxetine's proextinction effects, we integrated biochemical, electrophysiological, pharmacological, and behavioral techniques, using the extinction-impaired 129S1/Sv1mJ mouse strain. (nature.com)
  • Behavior was assessed in the home-cage, providing control over environmental factors, to reveal within-strain variability in numerous spontaneous behaviors. (uva.nl)
  • ROS and 8-OHdG were increased postirradiation and exhibited significant strain and time-dependent variability, but were not strongly predictive of radiation-induced lung diseases. (physiology.org)
  • CPBs mice, which showed a relatively high variability for fraying, appeared to be heterozygous for this character. (brillonline.com)
  • A total of 341 germline IGHV sequences were inferred in the wild-derived strains, including 247 not curated in the international ImMunoGeneTics information system. (garvan.org.au)
  • They include panels of recombinant inbred (RI) and chromosome substitution (CS) strains, also known as consomic strains. (jax.org)
  • Although the parental inbred strains-Inbred Long-Sleep (ILS) and Inbred Short-Sleep (ISS)-were derived originally by selection from an 8-way heterogeneous stock selected for differential sensitivity to sedative effects of ethanol, the LXS panel is also segregating for many other traits. (deepdyve.com)
  • H-2/Hh-1 allogeneic or parental-strain bone marrow grafts are eliminated in a determinant specific manner by NK cells. (elsevier.com)
  • Moreover, the dopaminergic system was activated differentially in the medial prefrontal cortex and striatum of the two strains by acute stress. (elsevier.com)
  • Mice and rats used in the laboratory derive from a variety of sources. (jax.org)
  • Inductions of FABP in hepatic cytosol by administration of tiadenol and clofibric acid were studied in rats, mice and guinea-pigs. (biomedsearch.com)
  • In rats and mice, [1-14C]oleic acid-binding capacity of hepatic cytosol was increased, in association with induction of peroxisomal beta-oxidation, by the administration of either the two peroxisome proliferators. (biomedsearch.com)
  • The peroxisome proliferators caused an induction of acyl-CoA hydrolase of lower-molecular-weight form alone in hepatic cytosol of mice, although inductions of two long-chain acyl-CoA hydrolases (higher- and lower-molecular-weight form) were brought about in hepatic cytosol of rats. (biomedsearch.com)
  • These features make the FVB/N strain advantageous to use for research with transgenic mice. (pnas.org)
  • The protocol should make it possible to undertake a large number of experiments with MSCs in transgenic mice that have previously not been possible. (bloodjournal.org)
  • 5 ] demonstrated changes in the position and or size of primary sensory visual, somatosensory, and auditory cortical regions in transgenic mice over expressing the transcription factor Emx2 . (beds.ac.uk)
  • The purpose of this presentation is to discuss some examples of the interplay between genotypes and environments, drawn from the behavioral responses of inbred strains of laboratory mice. (nap.edu)
  • The over-grooming behavior is seen in other strains, but the frequency is usually very low. (jax.org)
  • 1966. Activities associated with conflict behavior in mice. (jax.org)
  • 1986. Behavior associated alopecia areata in mice. (jax.org)
  • We report here a QTL analysis of aggressive behavior in NZB and A mice. (jneurosci.org)
  • H-FSS mice exhibited increased fear levels and a deficit in fear extinction (within-session) in the auditory fear-conditioning test, and depressive-like behavior in the acute forced swim stress test. (elsevier.com)
  • Here we report that neuronal expression of TTA can affect hippocampal cytoarchitecture and behavior in a strain-dependent manner. (jneurosci.org)
  • Because many groups, including ours, continue to use tet-off models to study neurological disorders, we undertook a series of systematic experiments to better characterize the interaction between strain background, TTA-induced neuronal loss, and behavior so that potential deficits could be identified and controlled. (jneurosci.org)
  • FVB mice show elevated aggressive behavior towards newly intruding FVB mice shortly after the new mouse's introduction, potentially due to chronically disrupted circadian rhythms. (wikipedia.org)