The variable phenotypic expression of a GENE depending on whether it is of paternal or maternal origin, which is a function of the DNA METHYLATION pattern. Imprinted regions are observed to be more methylated and less transcriptionally active. (Segen, Dictionary of Modern Medicine, 1992)
A class of untranslated RNA molecules that are typically greater than 200 nucleotides in length and do not code for proteins. Members of this class have been found to play roles in transcriptional regulation, post-transcriptional processing, CHROMATIN REMODELING, and in the epigenetic control of chromatin.
Genetically and clinically heterogeneous disorder characterized by low birth weight, postnatal growth retardation, facial dysmorphism, bilateral body asymmetry, and clinodactyly of the fifth fingers. Alterations in GENETIC IMPRINTING are involved. Hypomethylation of IGF2/H19 locus near an imprinting center region of chromosome 11p15 plays a role in a subset of Silver-Russell syndrome. Hypermethylation of the same chromosomal region, on the other hand, can cause BECKWITH-WIEDEMANN SYNDROME. Maternal UNIPARENTAL DISOMY for chromosome 7 is known to play a role in its etiology.
RNA which does not code for protein but has some enzymatic, structural or regulatory function. Although ribosomal RNA (RNA, RIBOSOMAL) and transfer RNA (RNA, TRANSFER) are also untranslated RNAs they are not included in this scope.
A syndrome of multiple defects characterized primarily by umbilical hernia (HERNIA, UMBILICAL); MACROGLOSSIA; and GIGANTISM; and secondarily by visceromegaly; HYPOGLYCEMIA; and ear abnormalities.
A well-characterized neutral peptide believed to be secreted by the LIVER and to circulate in the BLOOD. It has growth-regulating, insulin-like and mitogenic activities. The growth factor has a major, but not absolute, dependence on SOMATOTROPIN. It is believed to be a major fetal growth factor in contrast to INSULIN-LIKE GROWTH FACTOR I, which is a major growth factor in adults.
Animals that are generated from breeding two genetically dissimilar strains of the same species.
A highly fluorescent anti-infective dye used clinically as a topical antiseptic and experimentally as a mutagen, due to its interaction with DNA. It is also used as an intracellular pH indicator.
Congenital changes in the morphology of organs produced by exposure to ionizing or non-ionizing radiation.
A family of POU domain factors that bind the octamer motif ATTTGCAT in enhancer and PROMOTER REGIONS to regulate GENE EXPRESSION.
A group of alkylating agents derived from mustard gas, with the sulfur replaced by nitrogen. They were formerly used as toxicants and vesicants, but now function as antineoplastic agents. These compounds are also powerful mutagens, teratogens, immunosuppressants, and carcinogens.
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
One of several general transcription factors that are specific for RNA POLYMERASE III. It is a zinc finger (ZINC FINGERS) protein and is required for transcription of 5S ribosomal genes.
DNA constructs that are composed of, at least, elements such as a REPLICATION ORIGIN; TELOMERE; and CENTROMERE, that are required for successful replication, propagation to and maintenance in progeny cells. In addition, they are constructed to carry other sequences for analysis or gene transfer.
Diseases of rodents of the order RODENTIA. This term includes diseases of Sciuridae (squirrels), Geomyidae (gophers), Heteromyidae (pouched mice), Castoridae (beavers), Cricetidae (rats and mice), Muridae (Old World rats and mice), Erethizontidae (porcupines), and Caviidae (guinea pigs).
Addition of methyl groups to DNA. DNA methyltransferases (DNA methylases) perform this reaction using S-ADENOSYLMETHIONINE as the methyl group donor.
Nucleic acid regulatory sequences that limit or oppose the action of ENHANCER ELEMENTS and define the boundary between differentially regulated gene loci.
An intense itching sensation that produces the urge to rub or scratch the skin to obtain relief.
The relationship between the dose of administered radiation and the response of the organism or tissue to the radiation.
Penetrating, high-energy electromagnetic radiation emitted from atomic nuclei during NUCLEAR DECAY. The range of wavelengths of emitted radiation is between 0.1 - 100 pm which overlaps the shorter, more energetic hard X-RAYS wavelengths. The distinction between gamma rays and X-rays is based on their radiation source.
The amount of radiation energy that is deposited in a unit mass of material, such as tissues of plants or animal. In RADIOTHERAPY, radiation dosage is expressed in gray units (Gy). In RADIOLOGIC HEALTH, the dosage is expressed by the product of absorbed dose (Gy) and quality factor (a function of linear energy transfer), and is called radiation dose equivalent in sievert units (Sv).
A single, unpaired primary lymphoid organ situated in the MEDIASTINUM, extending superiorly into the neck to the lower edge of the THYROID GLAND and inferiorly to the fourth costal cartilage. It is necessary for normal development of immunologic function early in life. By puberty, it begins to involute and much of the tissue is replaced by fat.
The ability of some cells or tissues to survive lethal doses of IONIZING RADIATION. Tolerance depends on the species, cell type, and physical and chemical variables, including RADIATION-PROTECTIVE AGENTS and RADIATION-SENSITIZING AGENTS.
A member of the AGARICALES known for edible MUSHROOMS.
A genus of fungi in the family Ganodermataceae, order POLYPORALES, containing a dimitic hyphal system. It causes a white rot, and is a wood decomposer. Ganoderma lucidum (REISHI) is used in traditional Chinese medicine (MEDICINE, CHINESE TRADITIONAL).
Tumors or cancer of the PROSTATE.
A gland in males that surrounds the neck of the URINARY BLADDER and the URETHRA. It secretes a substance that liquefies coagulated semen. It is situated in the pelvic cavity behind the lower part of the PUBIC SYMPHYSIS, above the deep layer of the triangular ligament, and rests upon the RECTUM.
Specific molecular sites or structures on cell membranes that react with FIBROBLAST GROWTH FACTORS (both the basic and acidic forms), their analogs, or their antagonists to elicit or to inhibit the specific response of the cell to these factors. These receptors frequently possess tyrosine kinase activity.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
A fibroblast growth factor receptor that is found in two isoforms. One receptor isoform is found in the MESENCHYME and is activated by FIBROBLAST GROWTH FACTOR 2. A second isoform of fibroblast growth factor receptor 2 is found mainly in EPITHELIAL CELLS and is activated by FIBROBLAST GROWTH FACTOR 7 and FIBROBLAST GROWTH FACTOR 10. Mutation of the gene for fibroblast growth factor receptor 2 can result in craniosynostotic syndromes (e.g., APERT SYNDROME; and CROUZON SYNDROME).
A fibroblast growth factor receptor that regulates CHONDROCYTE growth and CELL DIFFERENTIATION. Mutations in the gene for fibroblast growth factor receptor 3 have been associated with ACHONDROPLASIA; THANATOPHORIC DYSPLASIA and NEOPLASTIC CELL TRANSFORMATION.
A fibroblast growth factor receptor with specificity for FIBROBLAST GROWTH FACTORS; HEPARAN SULFATE PROTEOGLYCAN; and NEURONAL CELL ADHESION MOLECULES. Several variants of the receptor exist due to multiple ALTERNATIVE SPLICING of its mRNA. Fibroblast growth factor receptor 1 is a tyrosine kinase that transmits signals through the MAP KINASE SIGNALING SYSTEM.
Refers to animals in the period of time just after birth.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.
Injections into the cerebral ventricles.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
The transmission and reproduction of transient images of fixed or moving objects. An electronic system of transmitting such images together with sound over a wire or through space by apparatus that converts light and sound into electrical waves and reconverts them into visible light rays and audible sound. (From Webster, 3rd ed)
Recording of visual and sometimes sound signals on magnetic tape.
Injuries to the PERIPHERAL NERVES.
An increased sensation of pain or discomfort produced by mimimally noxious stimuli due to damage to soft tissue containing NOCICEPTORS or injury to a peripheral nerve.
The nerves outside of the brain and spinal cord, including the autonomic, cranial, and spinal nerves. Peripheral nerves contain non-neuronal cells and connective tissue as well as axons. The connective tissue layers include, from the outside to the inside, the epineurium, the perineurium, and the endoneurium.
A nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity. The sciatic nerve, which is the main continuation of the sacral plexus, is the largest nerve in the body. It has two major branches, the TIBIAL NERVE and the PERONEAL NERVE.
The 31 paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment. The spinal nerve plexuses and the spinal roots are also included.
Disease or damage involving the SCIATIC NERVE, which divides into the PERONEAL NERVE and TIBIAL NERVE (see also PERONEAL NEUROPATHIES and TIBIAL NEUROPATHY). Clinical manifestations may include SCIATICA or pain localized to the hip, PARESIS or PARALYSIS of posterior thigh muscles and muscles innervated by the peroneal and tibial nerves, and sensory loss involving the lateral and posterior thigh, posterior and lateral leg, and sole of the foot. The sciatic nerve may be affected by trauma; ISCHEMIA; COLLAGEN DISEASES; and other conditions. (From Adams et al., Principles of Neurology, 6th ed, p1363)
Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.
A publication issued at stated, more or less regular, intervals.
Individual's rights to obtain and use information collected or generated by others.
A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.
The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
The evaluation by experts of the quality and pertinence of research or research proposals of other experts in the same field. Peer review is used by editors in deciding which submissions warrant publication, by granting agencies to determine which proposals should be funded, and by academic institutions in tenure decisions.
Diseases affecting the eye.

Carcinogenicity of triethanolamine in mice and its mutagenicity after reaction with sodium nitrite in bacteria. (1/6342)

Mice fed a diet containing 0.3 or 0.03% triethanolamine developed malignant tumors. Females showed a high incidence of tumors in lymphoid tissues, while this type was absent in males. Tumors in other tissues were produced at a considerable rate in both sexes, but no hepatoma was found. Triethanolamine was not mutagenic to Bacillus subtilis by itself, but it became mutagenic after reacting with sodium nitrite under acidic conditions or when the mixture was heated. Although N-nitrosodiethanolamine, a known carcinogen and mutagen, was detected in the reaction mixture by thin-layer chromatography, it may not be the main mutagenic product, because the product was a stable and direct mutagen and its mutagenic activity was destroyed by liver enzymes, unlike N-nitrosodiethanolamine. The lethal and mutagenic DNA damages produced by this unidentified product were susceptible to some extent to the repair functions of the bacteria.  (+info)

Involvement of tumor necrosis factor alpha and interleukin-1beta in enhancement of pentylenetetrazole-induced seizures caused by Shigella dysenteriae. (2/6342)

Neurologic manifestations, mainly convulsions, are the most frequent extraintestinal complications of shigellosis. We used an animal model to study the roles of tumor necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1beta) in Shigella-related seizures. Administration of Shigella dysenteriae 60R sonicate enhanced the sensitivity of mice to the proconvulsant pentylenetetrazole (PTZ) within 7 h. This was indicated by a significantly higher mean convulsion score and an increased number of mice responding with clonic-tonic seizures in the Shigella-pretreated group. Preinjection of mice with anti-murine TNF-alpha (anti-mTNF-alpha) or anti-murine IL-1beta (anti-mIL-1beta) 30 min prior to administration of Shigella sonicate abolished their enhanced response to PTZ at 7 h. Mean convulsion scores were reduced by anti-mTNF-alpha from 1.2 to 0.8 (P = 0.017) and by anti-mIL-1beta from 1.3 to 0.7 (P = 0.008). Preinjection of anti-mTNF-alpha also reduced the percentage of mice responding with clonic-tonic seizures, from 48 to 29% (P = 0.002), and preinjection of anti-mIL-1beta reduced it from 53 to 21% (P = 0. 012). Neutralization of TNF-alpha or IL-1beta did not protect the mice from death due to S. dysenteriae 60R. These findings indicate that TNF-alpha and IL-1beta play a role in the very early sensitization of the central nervous system to convulsive activity after S. dysenteriae administration. Similar mechanisms may trigger neurologic disturbances in other infectious diseases.  (+info)

A novel trans-complementation assay suggests full mammalian oocyte activation is coordinately initiated by multiple, submembrane sperm components. (3/6342)

To initiate normal embryonic development, an egg must receive a signal to become activated at fertilization. We here report that the ability of demembranated sperm heads to activate is abolished after incubation over the range 20-44 degreesC and is sensitive to reducing agents. On the basis of this observation, we have developed a microinjection-based, trans-complementation assay in order to dissect the heat-inactivated sperm-borne oocyte-activating factor(s) (SOAF). We demonstrate that the failure of heat-inactivated sperm heads to activate an egg is rescued by coinjection with dithiothreitol-solubilized SOAF from demembranated sperm heads. The solubilized SOAF (SOAFs) is trypsin sensitive and is liberated from demembranated heads in a temperature-dependent manner that inversely correlates with the ability of sperm heads to activate. This argues that SOAFs is a proteinaceous molecular species required to initiate activation. Injection of oocytes with mouse or hamster sperm cytosolic factors, but not SOAFs alone, induced resumption of meiosis, further suggesting that these cytosolic factors and SOAF are distinct. Collectively, these data strongly suggest that full mammalian oocyte activation is initiated by the coordinated action of one or more heat-sensitive protein constituents of the perinuclear matrix and at least one heat-stable submembrane component.  (+info)

Obstructive uropathy and hydronephrosis in male KK-Ay mice: a report of cases. (4/6342)

Uropathy associated with hydronephrosis was observed frequently in our male KK-Ay mouse colony during a long-term study of diabetes. The lesion occurred in 24 of the 31 KK-Ay male mice and accounted for the greatest number of spontaneous deaths among them. It was observed after 4 months of age and involved about hard plugs of altered seminal material resembling the seminal vesicle secretion. The plugs became impacted in the urethral bulb and the bladder. The penile anatomy, with its flexure, pressure on the urethra from the bulbocavernosus muscle, and the characteristic ability of the seminal fluid to easily coagulate to form the vaginal plug may have contributed to the lesion. Correlation between development of the uropathy and diabetes has not been established.  (+info)

Spinal antinociceptive synergism between morphine and clonidine persists in mice made acutely or chronically tolerant to morphine. (5/6342)

Morphine (Mor) tolerance has been attributed to a reduction of opioid-adrenergic antinociceptive synergy at the spinal level. The present experiments tested the interaction of intrathecally (i.t.) administered Mor-clonidine (Clon) combinations in mice made acutely or chronically tolerant to Mor. ICR mice were pretreated with Mor either acutely (40 nmol i.t., 8 h; 100 mg/kg s.c., 4 h) or chronically (3 mg/kg s.c. every 6 h days 1 and 2; 5 mg/kg s.c. every 6 h days 3 and 4). Antinociception was detected via the hot water (52.5 degrees C) tail-flick test. After the tail-flick latencies returned to baseline levels, dose-response curves were generated to Mor, Clon, and Mor-Clon combinations in tolerant and control mice. Development of tolerance was confirmed by significant rightward shifts of the Mor dose-response curves in tolerant mice compared with controls. Isobolographic analysis was conducted; the experimental combined ED50 values were compared statistically against their respective theoretical additive ED50 values. In all Mor-pretreated groups, the combination of Mor and Clon resulted in significant leftward shifts in the dose-response curves compared with those of each agonist administered separately. In all tolerant and control groups, the combination of Mor and Clon produced an ED50 value significantly less than the corresponding theoretical additive ED50 value. Mor and Clon synergized in Mor-tolerant as well as in control mice. Spinally administered adrenergic/opioid synergistic combinations may be effective therapeutic strategies to manage pain in patients apparently tolerant to the analgesic effects of Mor.  (+info)

Comparison of local anesthetic activities between optical isomers of cis-1-benzoyloxy-2-dimethylamino-1,2,3,4-tetrahydronaphthalene. (6/6342)

The optical isomers of cis-1-benzoyloxy-2-dimethylamino-1,2,3,4-tetrahydronaphthalene (YAU-17) were compared for their local anesthetic activity, acute toxicity, spasmolytic activity, and partition coefficient between chloroform and phosphate buffer. 1-YAU-17 was more active than d-YAU-17 in blocking the conduction of action potentials in isolated frog sciatic nerves. The difference in local anesthetic activities between the optical isomers was further substantiated by in vivo tests for corneal anesthesia, intracutaneous anesthesia and sciatic nerve block in quinea-pigs. Similarly, the i.v. injection to mice revealed a higher toxicity for 1-YAU-17 as compared to its d-isomer. In these tests, the potency ratios of the enantiomers ranged from 2 to 4, and the racemate had an intermediate potency. On the contrary, no difference among the compounds was found in their liposolubility, partition coefficient, and spasmolytic activity examined with isolated guinea-pig ileum. These results indicate that the steric factors play an important role in the production of different local anesthetic activities between the optical isomers of YAU-17, and their local anesthetic potency tends to be correlated to their intravenous acute toxicity but not to their spasmolytic activity.  (+info)

Diperamycin, a new antimicrobial antibiotic produced by Streptomyces griseoaurantiacus MK393-AF2. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities. (7/6342)

Antibacterial antibiotics, diperamycin (1) was produced in the culture broth of Streptomyces griseoaurantiacus MK393-AF2. Various spectroscopic analyses of 1 suggested that 1 belonged to a member of cyclic hexadepsipeptide antibiotic. Antibiotic 1 had potent inhibitory activity against various Gram-positive bacteria including Enterococcus seriolicida and methicillin-resistant Staphylococcus aureus.  (+info)

Uncoupling of in vivo torque production from EMG in mouse muscles injured by eccentric contractions. (8/6342)

1. The main objective of this study was to determine whether eccentric contraction-induced muscle injury causes impaired plasmalemmal action potential conduction, which could explain the injury-induced excitation-contraction coupling failure. Mice were chronically implanted with stimulating electrodes on the left common peroneal nerve and with electromyographic (EMG) electrodes on the left tibialis anterior (TA) muscle. The left anterior crural muscles of anaesthetized mice were stimulated to perform 150 eccentric (ECC) (n = 12 mice) or 150 concentric (CON) (n = 11 mice) contractions. Isometric torque, EMG root mean square (RMS) and M-wave mean and median frequencies were measured before, immediately after, and at 1, 3, 5 and 14 days after the protocols. In parallel experiments, nicotinic acetylcholine receptor (AChR) concentration was measured in TA muscles to determine whether the excitation failure elicited a denervation-like response. 2. Immediately after the ECC protocol, torque was reduced by 47-89 %, while RMS was reduced by 9-21 %; the RMS decrement was not different from that observed for the CON protocol, which did not elicit large torque deficits. One day later, both ECC and CON RMS had returned to baseline values and did not change over the next 2 weeks. However, torque production by the ECC group showed a slow recovery over that time and was still depressed by 12-30 % after 2 weeks. M-wave mean and median frequencies were not affected by performance of either protocol. 3. AChR concentration was elevated by 79 and 368 % at 3 and 5 days, respectively, after the ECC protocol; AChR concentration had returned to control levels 2 weeks after the protocol. At the time of peak AChR concentration in the ECC protocol muscles (i.e. 5 days), AChR concentration in CON protocol muscles was not different from the control level. 4. In conclusion, these data demonstrate no major role for impaired plasmalemmal action potential conduction in the excitation-contraction coupling failure induced by eccentric contractions. Additionally, a muscle injured by eccentric contractions shows a response in AChR concentration similar to a transiently denervated muscle.  (+info)

The basis for the resistance of the female and the susceptibility of the male ICR Swiss mouse to the diabetogenicity of the D variant of encephalomyocarditis virus (EMCV-D) is unknown. This pattern of disease resistance and susceptibility can be reversed if females are treated with testosterone and males are treated with estrogen before virus infection. As a possible explanation for this sex difference in disease development, differences in early antiviral host responses were explored. Cellular antiviral resistance mechanisms operative early in virus infection were evaluated in ICR Swiss mice of both sexes after intraperitoneal infection with virus. No differences were seen in splenic natural killer (NK) cell responses of male and female mice during the 1st wk of infection, during which only the males became diabetic. Depletion of NK cell activity with rabbit anti-asialo GM1 serum did not render the infected ICR Swiss female susceptible to virus-induced diabetes. Treatment of ICR Swiss mice with type I
Gender and genetic strain are two prominent variants that influence drug abuse. Although certain sex-related behavioral responses have been previously characterized in ICR mice, little is known about the effects of sex on morphine-induced behavioral responses in this outbred strain. Therefore, in this study, we investigated the sex differences of morphine-induced locomotion, anxiety-like and social behaviors in ICR mice. After morphine or saline exposure for four consecutive days (twice daily), increased locomotion, more time spent in the central area, as well as attenuated rearing and self-grooming behaviors were found in morphine-treated females in an open field; no differences were found in locomotion and the time spent in the central area between male and female controls. When interacting with the same-sex individuals, female controls were engaged in more social investigation, following, body contacting and self-grooming behaviors than controls; morphine exposure reduced contacting and ...
TY - JOUR. T1 - Differential global gene expression in red and white skeletal muscle. AU - Campbell, W. G.. AU - Gordon, S. E.. AU - Carlson, C. J.. AU - Pattison, J. S.. AU - Hamilton, M. T.. AU - Booth, F. W.. PY - 2001/6/5. Y1 - 2001/6/5. N2 - The differences in gene expression among the fiber types of skeletal muscle have long fascinated scientists, but for the most part, previous experiments have only reported differences of one or two genes at a time. The evolving technology of global mRNA expression analysis was employed to determine the potential differential expression of ∼3,000 mRNAs between the white quad (white muscle) and the red soleus muscle (mixed red muscle) of female ICR mice (30-35 g). Microarray analysis identified 49 mRNA sequences that were differentially expressed between white and mixed red skeletal muscle, including newly identified differential expressions between muscle types. For example, the current findings increase the number of known, differentially expressed ...
Most mammalian embryos implant on the uterine endometrium after hatching fromzona pellucida of the expanded blastocyst and pregnancy takes place. The blastocysts produceand control a variety of prostaglandins which activate a few proteolytic enzymes thatdissolve the zona pellucida of the embryos. In the present study, the goal was to investigatethe indomethacin and aspirin(inhibitors of cyclooxygenase pathway which regulates thepathway from arachidonic acid to prostaglandins), which can affect the hatching and implantationof the mouse embryos by the treatment of the different dose level of indomethacinand aspirin in the culture of mouse embryos.The female and male ICR mice, 6~8 weeks and were used for superovulation andmating and M16 was used as a basic culture medium.The above results can be summarized as following:1. Indomethacin seemed to inhibit the development of the mouse embryos and hatchingprocess because of inhibiting or blocking the activation of hatching related enzymes andhigh dose ...
Objective To evaluate the influence of saponin of Pearsonothuria graeffei(PGS) on hematopoietic modulators in myelosuppression mice.Method Male ICR mice were randomly divided into four groups: normal control group,model control group,low and high dose PGS groups.PGS was orally administered with 10 and 30 mg/kg.bw every day for 16 d.The mice in normal and model control groups were administered with 0.9% NaCl solution as placebo.On the 7th day,all mice except those in the normal group were injected intraperitoneally with 100 mg/kg cyclophosphamide once a day for 3 d to induce myelosuppressed animal model.The lung conditioned medium(LCM),spleen cell conditioned medium(SCM) and peritoneal cavity macrophage conditioned medium(PMΦCM) treated with Pearsonothuria graeffei were prepared to observe the effects on proliferation of bone marrow cells and formation of hematopoietic progenitor cells colonys including granulocyte-monocyte colony forming units(CFU-GM),colony-forming units-erythroid(CFU-E) and colony
In this study, we prepared BLs of submicron size (~ 500 nm). Male ICR mice were injected intravenously with Evans blue dye (EB) which binds with albumin in blood stably. Subsequently, BLs were also injected and then right hemispheres were exposed with a 1.0 MHz pulsed HIFU (10% duty, 10-60 sec) with different intensities (0.1-1.5 kW/cm2). After 3 hours, their treated mice were infused intravenously with PBS as a perfusion medium by a syringe pump at a constant speed. The mice were perfused with PBS via the left ventricle. After perfusion and brain removal, the brains were then divided into right and left hemispheres before measuring the amount of EB extravasated. Non-focused left hemispheres of the treated mice were used as the control. Samples were weighed, soaked in formamide solution, and the incubated for 24 hours at 55 degrees. After that, the extracted dye was finally determined using a spectrophotometer at 620 nm. Similarly, FITC-dextrans (molecular weight 70-2000 kDa) were also delivered ...
BioAssay record AID 424689 submitted by ChEMBL: Antiosteoporosis activity against ovariectomized ICR mouse assessed as dry femur weight at 110.3 nmol/kg, po after 30 mins.
In order to examine the effect of the inventive protein conjugates with I7Ser-G-CSF having a substitution of 17th amino acid by serine, the in vivo activities of wild-type G-CSF, a commercially available 20 kDa PEG-G-CSF complex and 17Ser-G-CSF-PEG-IgG conjugate were compared. The 17Ser-G-CSF-PEG-IgG conjugate of,the present invention was dissolved in a solvent comprising 20 mM sodium phosphate, 1 % glycine and 0.25 % mannitol (pH 7.0). Wild-type methionyl G-CSF complex (Filgrastim, Amgen, USA) and 20 kDa PEG modified G-CSF (Neulasta, Amgen, USA) dissolved in the same solvent were employed as a comparative group. Male 7-week-old ICR mice were purchased from Samtaco Bio (Korea) and subjected to an acclimation period for a week before the experiment. At the beginning of the experiment, the weight of ICR mice were in the range of 30 ~ 35 g. They were allowed to freely ingest formula feed (Samyang Corporation, Korea) and water during the acclimation and experiment, and kept in a cage under the ...
Inbr ?. Albino c. Origin: Outbred Jcl:ICR mice inbred in 1976 by Y. Yoshimura (Cent. Inst. for Exp. Anim., Japan). Maintained by Shi. ...
BAZ2-ICR (4-{4-(1-Methyl-1H-pyrazol-4-yl)-1-[2-(1-methyl-1H-pyrazol-4-yl)-ethyl]-1H-imidazol-5-yl}-benzonitrile);≥98% HPLC; This compound is a featured product for Gene Regulation research; BAZ2-ICR is a chemical probe for BAZ2A/B bromodomains;
BAZ2-ICR is a potent, selective, cell active and orally active BAZ2A/B bromodomains inhibitor with IC50s of 130 nM and 180 nM, and Kds of 109 nM and 170 nM, respectively. BAZ2-ICR shows 10-15-fold selectivity for binding BAZ2A/B over CECR2 and >100-fold selectivity over all other bromodomains. BAZ2-ICR is an epigenetic chemical probe ...
To investigate the mechanism of the combined effects of chlorogenic acid (CGA) and caffeine on lipid metabolism in high-fat diet-induced obese mice, eighty female ICR mice were randomly divided into eight groups and fed with a high-fat diet with/without CGA and/or caffeine for 14 weeks. The combination of CG
Obesity has been found to be associated with increased incidence of various metabolic disorders. Anti-obesity interventions are therefore urgently needed. An earlier study has demonstrated that treatment with an herbal formula MCC, which comprises the fruit of Momordica charantia (MC), the pericarpium of Citri reticulate (CR) and L-carnitine (CA), reduced the weight gain in high fat diet (HFD)-fed mice. In the present study, we investigated the effect of long-term treatment with MCC (6 g/kg/day x 40 doses) and various combinations of its constituents in HFD-fed female ICR mice. Body weight change was monitored during the course of the experiment. Total and differential adiposity, plasma lipid contents, metabolic enzyme activities and mitochondrial coupling efficiency in skeletal muscle were measured. Glucose homeostasis was also assessed. Results showed that HFD increased the body weight, total and differential adiposity, and plasma lipid contents as well as impaired metabolic status in skeletal ...
Curcumin from turmeric is commonly used worldwide as a spice and has been demonstrated to possess various biological activities. This study investigated the protective effect of curcumin on a mouse model of cadmium (Cd)-induced hypertension, vascular dysfunction and oxidative stress. Male ICR mice were exposed to Cd (100 mg/L) in drinking water for eight weeks. Curcumin (50 or 100 mg/kg) was intragastrically administered in mice every other day concurrently with Cd. Cd induced hypertension and impaired vascular responses to phenylephrine, acetylcholine and sodium nitroprusside. Curcumin reduced the toxic effects of Cd and protected vascular dysfunction by increasing vascular responsiveness and normalizing the blood pressure levels. The vascular protective effect of curcumin in Cd exposed mice is associated with up-regulation of endothelial nitric oxide synthase (eNOS) protein, restoration of glutathione redox ratio and alleviation of oxidative stress as indicated by decreasing superoxide production in
Consequences of pain include stimulation of some behaviors (e.g. vocalization, reflexive withdrawal from stimuli), and depression of others (e.g. exercise, and work). Pain-related decreases in behavior are among the primary diagnostic and treatment concerns for physicians, but preclinical research has often ignored this important endpoint. This discrepancy between basic research and clinical application may be one obstacle to the development of new pain treatments. In the present study, we modeled pain-related depression of behavior by examining nesting behavior in male ICR mice. Nest building is an innate mouse behavior that is sensitive to depression by a pain stimulus, and pain-related depression of nesting is blocked by the clinically effective nonsteroidal anti-inflammatory drug (NSAID) ketoprofen. This project examines effects of monoamine uptake inhibitors with varying selectivity for serotonin (5HT), norepinephrine (NE) and dopamine (DA) on pain-related depression of nesting. Citalopram ...
Pregnant ICR mice (Nihon-SLC) were used for in utero electroporation. Noon of the day at which the vaginal plug was detected was designated as embryonic day 0.5 (E0.5) and E19.5 was defined as P0.5. In utero electroporation was conducted on E13.5-13.75 embryos as described previously (Hatanaka et al., 2004) with minor modifications. Briefly, a 1-1.5 μl plasmid solution was injected into the lateral ventricle and 30 V or 40 V electric pulses of 50 ms duration were delivered at 200 ms intervals. Plasmids were prepared with the NucleoBond Midi Kit (Macherey-Nagel), suspended in PBS (0.1 m, pH 7.4) and electroporated at the following final concentrations: 1.0 μg/μl pCAG-EGFP-IRES-mito-mCherry for analysis of the mitochondrial distribution during the development of dendritic arbors; 3.0 μg/μl pCAG-Mfn1 and 1.0 μg/μl pCAG-EGFP-IRES-mito-mCherry for analysis of the mitochondrial distribution and dendritic morphology in Mfn1-overexpressing neurons; 3.0 μg/μl pCAG-Mfn1 and 1.0 μg/μl ...
With nobody above him, ICR director Paul Workman was seemingly investigating himself, and found two female colleagues guilty of placing fake data into his papers, primarily the ICR emeritus Ann Jackman. One paper was retracted, another received an outrageous correction. The previous ICR CEO, Alan Ashworth, together with his right-hand man Chris Lord, have their…
With nobody above him, ICR director Paul Workman was seemingly investigating himself, and found two female colleagues guilty of placing fake data into his papers, primarily the ICR emeritus Ann Jackman. One paper was retracted, another received an outrageous correction. The previous ICR CEO, Alan Ashworth, together with his right-hand man Chris Lord, have their…
Hayashi and collaborators profiled the EGF dependent microRNAs of the fetal mouse submandibular gland at embryonic day 13. Avraham and colleagues, described a
Complete information for ICR4 gene (Genetic Locus), Ichthyosis Congenita IV, Ichthyosis-Prematurity Syndrome, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Abcam provides specific protocols for Anti-ErbB 2 antibody [ICR55] (ab11711) : Immunoprecipitation protocols, Immunohistochemistry protocols, Western blot…
You can click on column titles to obtain more information about the subject. You can click on the NO DATA to find out why data is missing. 0 value does not mean that the value was missing. Missing values are indicated by a NO DATA label. For microbial results, 0 indicates that a sample was analyzed, but that no microbes were found. For DBP results, 0 may indicate that a sample was analyzed, but that the result was less than the lowest value that the analytical method can reliably report ...
The nanoGUNE Cooperative Research Center (CIC) is a Basque research center set up with the mission to conduct excellent research in nanoscience and nanotecnology with the aim of increasing the Basque Countrys business competitiveness and economic growth.
Processed Chuanwu (PCW), the mother root of Aconitum carmichaelii Debeaux, has been widely used as a classic Traditional Chinese Medicine for pain relieve for over two millennia clinically. However, its action on chronic inflammatory pain has not been clarified. Here, we investigated the antinociceptive effect of PCW in complete freunds adjuvant (CFA)-induced mice and its possible mechanisms associated with opioid system and TRPV1 ion channel. Male ICR mice were intraplantarly injected with CFA. PCW (0.34, 0.68 and 1.35 g/kg) was orally given to mice once a day for 7 days. Von frey hairs and plantar test were assessed to evaluate the antinociceptive effect of PCW. To investigate the participation of dynorphin/opioid system in PCW antinociception, subtype-specific opioid receptor antagonists or anti-dynorphin A antiserum were used. To eliminate other central mechanisms that contribute to PCW antinociception, hot plate (50 °C) test were performed. Further, involvements of
Methods Bone marrow cells (BMCs) were obtained from 5-week-old male ICR mice and cultured to be differentiated into osteoclasts with M-CSF and RANKL in the presence or absence of IL-1β, TG, or TAC. The formation of osteoclasts was evaluated by tartrate-resistant acid phosphatase (TRAP) staining and resorption pit assay with dentine slice. The molecular mechanisms of the above effects of TAC on osteoclastogenesis were investigated by using RT-PCR and immunoblotting for osteoclast specific and ER stress signaling molecules, including PERK, IRE1, GRP78, eIF2α, c-Fos and NFATc1.. ...
The metabolites formed, i.e. diethylphosphoric acid, diethylthiophosphoric acid and the derivatives of pyrimidinyl ring, are eliminated mainly via the kidneys. Only minimal quantities of the metabolites were detected in milk and eggs. 6.2.1 In vivo metabolic transformations 6.2.1.1 Mice When male ICR mice (number not stated) were treated orally with diazinon or [pyrimidine14C] diazinon at 50 or 75 mg/kg body weight, one half of the high-dose animals died and the rest showed symptoms (sweating, crouching) (Miyazaki et al., 1970; Sekine, 1972). At the low dose, no signs of toxicity were observed. Metabolism and excretion occurred rapidly, and the metabolites diazoxon, O, O-diethyl- O-[2-(alpha-hydroxyisopropyl)-4-methyl)-6-pyrimidinyl] phosphorothioate, and O, O-diethyl- O-(2-(2-propenyl)-4-methyl-6- pyrimidinyl) phosphorothioate were found in the urine 1 h after treatment. Most of the metabolites were found in urine 6 h after treatment, but metabolism was not identical in the two dose groups. In ...
Resveratrol (RES) is a well-known phytocompound and food component which has antioxidative and multifunctional bioactivities. However, there is limited evidence for the effects of RES on physical fatigue and exercise performance. The purpose of this study was to evaluate the potential beneficial effects of trans-RES on fatigue and ergogenic functions following physiological challenge. Male ICR mice from four groups (n = 8 per group) were orally administered RES for 21 days at 0, 25, 50, and 125 mg/kg/day, which were respectively designated the vehicle, RES-25, RES-50, and RES-125 groups. The anti-fatigue activity and exercise performance were evaluated using forelimb grip strength, exhaustive swimming time, and levels of serum lactate, ammonia, glucose, and creatine kinase (CK) after a 15-min swimming exercise. The exhaustive swimming time of the RES-25 group (24.72 ± 7.35 min) was significantly (p = 0.0179) longer than that of vehicle group (10.83 ± 1.15 min). A trend analysis revealed that RES
TY - JOUR. T1 - Attenuating effect of clock mutation on triglyceride contents in the ICR mouse liver under a high-fat diet. AU - Kudo, Takashi. AU - Tamagawa, Toru. AU - Kawashima, Mihoko. AU - Mito, Natsuko. AU - Shibata, Shigenobu. PY - 2007/8. Y1 - 2007/8. N2 - Energy homeostasis is subjected to a circadian control that synchronizes energy intake and expenditure. The transcription factor CLOCK, a key component of the molecular circadian clock, controls many kinds of rhythms, such as those for locomotor activity, body temperature, and metabolic functions. The purpose of the present study is to understand the function of the Clock gene during lipid metabolism in the liver using Clock-mutant mice. Clock-mutant mice with an ICR background were fed a high-fat diet for 13 weeks, and liver triglyceride, serum triglyceride, and serum free fatty acid levels were examined. Triglyceride content in the liver was significantly less increased in Clock-mutant mice on a high-fat diet compared to wild-type ...
Abstract The collagen content of the liver, measured as hepatic hydroxyproline, was examined for a period of up to 52 weeks following Schistosoma mansoni infection. Hepatic fibrosis was much more marked in S. mansoni-infected mice of an outbred ICR strain than in C57BL/6J mice, while C3H/HeN mice occupied an intermediate position. The marked difference in hepatic fibrosis in ICR and C57BL/6J mice correlated with more rapid in vitro synthesis of collagen by the livers of infected ICR mice. Strains of mice exhibiting high and low levels of fibrosis provide an excellent tool for examining mechanisms of murine schistosomal hepatic fibrosis and its genetic regulation.
A network of tubular lysosomes extends through the cytoplasm of J774.2 macrophages and phorbol ester-treated mouse peritoneal macrophages. The presence of this network is dependent upon the integrity of cytoplasmic microtubules and correlates with high cellular rates of accumulation of Lucifer Yellow (LY), a marker of fluid phase pinocytosis. We tested the hypothesis that the efficiency of LY transfer between the pinosomal and lysosomal compartments is increased in the presence of tubular lysosomes by asking how conditions that deplete the tubular lysosome network affect pinocytic accumulation of LY. Tubular lysosomes were disassembled in cells treated with microtubule-depolymerizing drugs or in cells that had phagocytosed latex beads. In unstimulated peritoneal macrophages, which normally contain few tubular lysosomes and which exhibit relatively inefficient transfer of pinocytosed LY to lysosomes, such treatments had little effect on pinocytosis. However, in J774 macrophages and phorbol ...
Injury and recovery of intestinal function following 1000 rads whole-body X-irradiation of female ICR/JCL mice was investigated by assaying activities of three enzymes (invertase, L-leucine aminopeptidase, alkaline phosphatase). By comparing changes in these enzyme activities with the epithelial cell kinetics of total DNA synthesizing cell number and total cell number, the causal relationships between functional changes in the small intestine and the epithelial cell kinetics involved in the recovery process were studied. After cell injury from irradiation, first the number of DNA synthesizing cells, second the number of total cells, and last the enzyme activities decreased to the minimum value. During recovery, the order was the same: first the DNA synthesizing cell number, then the total cell number, and finally the enzyme activities. This injury process was induced by epithelial cell death in the crypt, and the subsequent recovery was the result of epithelial cell proliferation and ...
Exocrine gland-secreting peptides (ESPs) are a protein family involved in the pheromonal communication of rodents. ESP1 is a lacrimal peptide synthesized by the extraorbital glands of males of specific mouse strains that modulates the sexual behavior in females. Reportedly, BALB/c males, that produce high level of ESP1 in the tear fluid, were shown to enhance the lordosis behavior in C57BL/6 females during mating. In contrast, C57BL/6 and ICR males, both unable to express ESP1, failed to modulate this sexual behavior. Nonetheless, ICR males did become competent to enhance lordosis behavior in C57BL/6 females providing these were pre-exposed to ESP1. To exclude any strain differences, here, we investigated the pheromonal role of the extraorbital glands and indirectly of ESP1 in animals of the same strain. This was performed by applying the lordosis experimental paradigm in BALB/c mice before and after the surgical removal of these glands in males. The excision of the extraorbital glands reduced but did
Animals. Sympathetic ganglia, skeletal muscles, and brains were dissected from timed embryonic or postnatal mice. Mice bearing a targeted mutation of the rapsyn gene have been described previously (Gautam et al. 1995) and were maintained on a 129SV × C57BL6 hybrid background. Homozygous mutants were readily identified because they died within a few hours of birth, but their genotype was confirmed by PCR. Littermates of the rapsyn mutants or wild-type C57BL6 (The Jackson Laboratory, Bar Harbor, ME) or ICR mice (Harlan Sprague Dawley, Indianapolis, IN) were used as controls.. Antibodies. Four rat monoclonal antibodies to AChR subunits were obtained from Jon Lindstrom (University of Pennsylvania) and from the Developmental Studies Hybridoma Bank (Iowa City, IA). Monoclonal antibody (mAb) 35 recognizes mouse AChR α (α1) subunit; mAb 210 recognizes mouse AChR α1 and α5 subunits; mAb 299 recognizes mouse AChR α4 subunit; and mAb 270 recognizes mouse AChR β2 subunit (Lindstrom, 1996). Two ...
J:79832 Hoffman MP, Kidder BL, Steinberg ZL, Lakhani S, Ho S, Kleinman HK, Larsen M, Gene expression profiles of mouse submandibular gland development: FGFR1 regulates branching morphogenesis in vitro through BMP- and FGF-dependent mechanisms. Development. 2002 Dec;129(24):5767-78 ...
Two mutants of Arabidopsis thaliana that are resistant to growth inhibition by indole-3-acetic acid (IAA)-phenylalanine have been isolated. Both mutants were 2- to 3-fold more resistant than wild type to inhibition by IAA-phenylalanine, IAA-alanine, and IAA-glycine in root growth assays. The mutant icr1 (but not icr2) also shows some resistance to IAA-aspartate. Studies using 3H-labeled IAA-phenylalanine showed that the uptake of conjugate from the medium by icr1 was the same as wild type and was reduced by about 25% in icr2. No differences in hydrolysis of the exogenous conjugate were detected between the mutants and their wild-type parents. There was no significant metabolism of the IAA released from the [3H]IAA-phenylalanine, whereas exogenous [3H]IAA was rapidly metabolized to two unidentified products considerably more polar than IAA. Analysis of a cross between icr1 and icr2 indicated that these mutations were at distinct loci and that their effects were additive, and preliminary mapping ...
ICR has also published tens of books and a laymans magazine called Acts & Facts. Last year it participated in making the documentary The Mysterious Islands. ICR has an educational centre in Dallas, Texas, and for 16 years operated the Museum of Creation and Earth History at Santee, California. The museum is currently run by the Life and Light Foundation ...
Publications of the Cellular & Molecular Logic Team, Integrative network biology initiative (INBi) Section of Cell and Molecular Biology, The Institute of Cancer Research (ICR)
VANCOUVER, April 3, 2017- Sierra Oncology Collaborator ICR Reports Preclinical Synthetic Lethality Data for Chk1 Inhibitor SRA737 at AACR.
The author recounts his visit to the ICR museum opened in 1992. This article is a mostly impartial description of the museum exhibits and some of its patrons.
Real photo taken from my roof. With OMdv logo (created by Rugyada) and Nitrogen symbol. Published for OpenMandriva Nitrogen Wallpapers. Processed with Gimp. - Nitrogen_C_jcl.jpg
TY - JOUR. T1 - Zerumbone, a sesquiterpene in subtropical ginger, suppresses skin tumor initiation and promotion stages in ICR mice. AU - Murakami, Akira. AU - Tanaka, Takuji. AU - Lee, Ji Yoon. AU - Surh, Young Joon. AU - Kim, Ha Won. AU - Kawabata, Kyuichi. AU - Nakamura, Yoshimasa. AU - Jiwajinda, Suratwadee. AU - Ohigashi, Hajime. PY - 2004/7/1. Y1 - 2004/7/1. N2 - We recently showed that zerumbone, a sesquiterpene found in subtropical ginger, suppresses colonic tumor marker formation in rats and induces apoptosis in colon cancer cell lines. In our present study, the anti-tumor initiating and promoting activities of zerumbone in mouse skin were evaluated using a conventional 2-stage carcinogenesis model. A single topical pretreatment to mouse skin (2 μmol) 24 hr before application of dimethylbenz[a]anthracene (0.2 μmol) markedly suppressed tumor incidence by 60% and the number of tumors by 80% per mouse. Repeated pretreatment (16 nmol) twice weekly during the post-initiation phase reduced ...
The effects of embryo number and incubation volume on the development of mouse embryos were evaluated. The growth rate of two-cell mouse embryos to attached blastocyst stage and the growth rate of blastocysts to early somite stage were assessed after culture in different incubation volumes and embryo densities. Embryos were collected from ICR female mice superovulated with pregnant mare serum gonadotropin and human chorionic gonadotropin and mated by ICR males. In experiment 1, groups of one, five, ten, twenty 2-cell embryos were cultured in 10-, 50-, 500-, 1000-microliter drops of BWW media under mineral oil at 37 degrees C in a humidified atmosphere of 5% CO2 and 95% air. As the incubation volume decreased, significantly ( ...
The effect of chronic (CCR) and intermittent (ICR) caloric restriction on serum adiponectin and leptin levels was investigated in relation to mammary tumorigenesis. 10-wks old MMTV-TGF-alpha female mice were assigned to ad libitum-fed (AL) (AIN-93M diet), ICR (3-wks 50% caloric restriction, AIN-93M-mod diet, 2x protein, fat, vitamins, and minerals followed by 3-wks 100% AL consumption of AIN-93M), and CCR (calorie and nutrient intake matched for each 6-wks ICR cycle, ~75% of AL) groups. Mice were sacrificed at 79 (end of restriction) or 82 (end of refeeding) wks of age. Serum was obtained in cycles 1, 3, 5, 8, 11 and terminal. Mammary tumor incidence was 71.0%, 35.4%, and 9.1% for AL, CCR and ICR mice, respectively. Serum adiponectin levels were similar among groups with no impact of either CCR or ICR. Serum leptin level rose in AL mice with increasing age but was significantly reduced by long-term CCR and ICR. The ICR protocol was also associated with an elevated adiponectin:leptin ratio. In ...
Bacterial infection is one of the major factors contributing to the compromised healing in chronic wounds. Sometimes bacteria biofilms formed on the wound are more resistant than adherent bacteria. Cold atmosphere plasma (CAP) has already shown its potential in contact-free disinfection, blood coagulation, and wound healing. In this study, we integrated a multimodal imaging system with a portable CAP device for image-guided treatment of infected wound in vivo and evaluated the antimicrobial effect on Pseudomonas aeruginosa sample in vitro.15 ICR mice were divided into three groups for therapeutic experiments:(1) control group with no infection nor treatment (2) infection group without treatment (3) infection group with treatment. For each mouse, a three millimeters punch biopsy was created on the dorsal skin. Infection was induced by Staphylococcus aureus inoculation one day post-wounding. The treated group was subjected to CAP for 2 min daily till day 13. For each group, five fixed wounds ...
Ion in an Eppendorf microfuge for 20 minutes at 13000 rpm at 4uC to remove insoluble debris. The supernatant was either used directly or stored at 280uC.Expression and Purification of GST-Fusion ProteinsAll the GST-fusion proteins were produced in Rosetta E.Coli cells, growing in YTx2 medium, by induction with 0.1 mM IPTG for three hours. Cells were lysed in the presence of 100 mM PMSF with seven 20-s sonicator pulses 50 duty on ice. The resulting lysate was centrifuged for 40 min at 12,000 rpm at 4uC. The proteins were then purified from the lysate by binding to glutathione-Sepharose 4B beads (Amersham Biosciences) according to the manufacturers instructions; the GST-fusion proteins were eluted with 30 mM glutathione, 50 mM Tris-HCl, pH 7.5, and 120 mM NaCl.Extraction of Mouse TissuesThe tissues from the ICR mice were frozen at 280uC and the lysates were prepared immediately before the Western blot experiment. The tissues were homogenized in RIPA buffer 50 mM Tris HCl, pH 8.0, 150 mM NaCl, 1 ...
ICR Concreting and Landscaping P/L in Acacia Gardens, NSW, 2763. Business contact details for ICR Concreting and Landscaping P/L including phone number, reviews & map location - TrueLocal
Terpos, E; Morgan, G; Dimopoulos, MA; Drake, MT; Lentzsch, S; Raje, N; Sezer, O; García-Sanz, R; Shimizu, K; Turesson, I; Reiman, T; Jurczyszyn, A; Merlini, G; Spencer, A; Leleu, X; Cavo, M; Munshi, N; Rajkumar, SV; Durie, BGM; Roodman, GD (2013-06) ...
This study compared the in-vitro properties and in-vivo effects of Escherichia coli filaments, spheroplasts and normal cells in a murine thigh infection model. E. coli was exposed to ceftazidime, meropenem or saline to obtain filaments, spheroplasts or normal bacilli, which were then injected into neutropenic mice. After 24 h, morphology, CFUs, local and circulating endotoxin levels, cytokine levels and mortality were recorded, and correlations between bacterial and host parameters of infection were investigated. Filaments and spheroplasts contained more endotoxin/CFU than controls. Histological studies showed that morphologically altered bacteria changed into rod-shaped cells in the absence of antibiotics. Bacterial spread to the liver was significantly higher in mice challenged with rod-shaped cells, compared with antibiotic-exposed bacteria (p 0.007). Muscle endotoxin levels correlated significantly with circulating interleukin (IL)-6 and tumour necrosis factor (TNF)-alpha, and both ...
The aim of this research I to determine, at the ultrastructural level, the localization and distribution of individual sugar sugar moieties and terminal sialylated sequences of the secretory products of the mouse SMG of both sexes. We therefore investigated the lectin receptors of control and sialidase-treated sections by a post-embedding approach using horse radish peroxidase (HRP)-conjugates (PNA, DBA, LTA, WGA, Con A), anti-HRP antibody and protein A-gold. Qualitative and quantitative differences occurred in the acinar products of males and females. Sialidase digestion revealed that the acceptor sugar for terminal sialic acids exhibit a different expression in the electron-lucent granules of acinar cells. The occurrence of terminal sialic acid-alpha-N-acetylgalactosamine disaccharide was prominent in male acinar cells in contrast to a modest presence in female. In addition, the terminal sequence sialic acid beta-galactose showed a homogeneous location in the male secretory products and a ...
Canscora lucidissima (Levl. & Vaniot) Hand.-Mazz. (C. lucidissima), mainly distributed in southern China, has been shown to be effective in the treatment of inflammatory diseases. However, the underlying mechanism of its anti-inflammatory effect is not fully understood. In this study, we investigated the anti-inflammatory mechanism of ethanol extract of C. lucidissima (Cl-EE) in lipopolysaccharide (LPS)-induced inflammatory models. ELISA, real-time PCR, Western blot and luciferase reporter assay were used for the experiments in vitro, and ICR mouse endotoxemia model was used for in vivo test. Our data showed that Cl-EE reduced the production of NO by down-regulating the mRNA and protein expression of inducible nitric oxide synthase (iNOS) in LPS-activated RAW 264.7 cells. Meanwhile, it potently decreased other proinflammatory mediators, such as TNF-α, IL-6, MCP-1 and IL-1β at the transcriptional and translational levels. Further study indicated that Cl-EE did not affect NF-κB signaling pathway but
References:. Nakayama K, Kagawa Y, et al.:A single nucleotide polymorphism in the FADS1/FADS2 gene is associated with plasma lipid profiles in two genetically similar Asian ethnic groups with distinctive differences in lifestyle. Hum Genet. In press. 2010. Munkhtulga, L.Kagawa, Y.: Regulatory SNP in the RBP 4 gene modified the expression in adipocytes and associated with BMI. Obesity in press, 2009. Higuchi, T., Kagawa, Y. et al. : Levels of plasma @insulin, leptin and adiponectin, and activities of key enzymes in carbohydrate metabolism in skeletal muscle and liver in fasted ICR mice fed dietary n-3 polyunsaturated fatty acids. J. Nutr. Biochem. 19: 577-586 2008.. Nakayama, K., Kagawa, Y. et al.: Comparative study of polymorphisms on genes associated with lifestyle related diseases in Asian and Pacific Populations. Asia-Pacific Journal of Public Health.,20, Supplement, 173-179 2008. Kageyama, M., Hiraoka, M., Kagawa, Y.: Relationship between genetic polymorphism, serum folate and homocysteine ...
A commonly expressed protein in skin - periostin - can directly activate itch-associated neurons in the skin, according to new research from North Carolina State University.
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Rat Monoclonal Anti-Bromodeoxyuridine/BrdU Antibody (BU1/75 (ICR1)) [Biotin]. Proliferation Marker. Validated: WB, ICC/IF, IHC, IHC-Fr, IHC-P. Tested Reactivity: Mouse, Non-species specific. 100% Guaranteed.
canSAR Cancer Drug Discovery Platform | ICR CRUK Cancer Therapeutics Unit | Cancer | Browse Molecular targets, 3D Structures, Protein families, Compound, Diseases, PDB, Genes
canSAR Cancer Drug Discovery Platform | ICR CRUK Cancer Therapeutics Unit | Cancer | Browse Molecular targets, 3D Structures, Protein families, Compound, Diseases, PDB, Genes
혈관주위배액이란 대뇌피질에서 뇌안의 대사산물들이나 작은 분자량의 펩티드들이 혈관 바깥의 혈관주위공간에서 조직액과 함께 혈관과 반대되는 방향으로 피질을 빠져나가는 현상을 의미한다. 혈관주위배액현상이 있다고 알려진지는 오래되었으나 그 현상을 정량화할 수 있는 지표에 대해서는 합의된 방법이 없었다. 뿐만 아니라 이 혈관주위 배액현상이 동맥벽을 타고 지주막하공간으로 빠져나가는지 정맥주변을 통해서 지주막하 공간으로 빠져나가는지, 그 방향성에 대해서도 상반된 결과들이 보고되어 논쟁이 있는 상황이다. 기존의 이광자 현미경을 이용한 관찰방법은 혈관주위배액현상을 파악하는데 시공간적인 정보가 다소 부족한 측면이 있다. 따라서 두개골 창을 제작하고 형광물질이 부착된 덱스트란을 중심에 주사하여 두개골 창 전체영역에서 ...
Study Flashcards On ICR - Pleuritis (rb) at Cram.com. Quickly memorize the terms, phrases and much more. Cram.com makes it easy to get the grade you want!
Enjoy ICR resources in bite-size amounts. If you have some ICR resources at home, see how you can integrate them into your creation teaching time. (If you dont have any, visit ICR.org/store to order.) Books in our Science for Kids and Guide to series cover a new topic on every page. Consider reading it aloud together each day. Our DVD series, like Uncovering the Truth about Dinosaurs, are broken into 22-minute episodes. If they watch one episode daily, you can finish most series in just a few days ...
Scientists have succeeded in making mice cerebral cortex grow dramatically more convoluted. They developed a line of transgenic mice that carried a variant of a
Harel, I; Maezawa, Y; Avraham, R; Rinon, A; Ma, H-Y; Cross, JW; Leviatan, N; Hegesh, J; Roy, A; Jacob-Hirsch, J; Rechavi, G; Carvajal, J; Tole, S; Kioussi, C; Quaggin, S; Tzahor, E (NATL ACAD SCIENCES, 2012-11-13) ...
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Spammers have clearly rallied following the McColo takedown, and overall spam volume growth during Q1 2009 was the strongest its been since early 2008, increasing an average of 1.2% per day. To put that number into
... mice, inbred dba MeSH B01.050.157.520.480 - mice, inbred hrs MeSH B01.050.157.520.510 - mice, inbred icr MeSH B01.050.157.520. ... mice, inbred dba MeSH B01.050.199.520.520.480 - mice, inbred hrs MeSH B01.050.199.520.520.510 - mice, inbred icr MeSH B01.050. ... mice, inbred a MeSH B01.050.157.520.318 - mice, inbred akr MeSH B01.050.157.520.338 - mice, inbred balb c MeSH B01.050.157.520. ... mice, inbred a MeSH B01.050.199.520.520.318 - mice, inbred akr MeSH B01.050.199.520.520.338 - mice, inbred balb c MeSH B01.050. ...
Her first work in the lab helped to elucidate the sequence diversity of 20 inbred mouse strains based on substitutions, ... ICR), Ideraabdullah explored whether there are regions outside the ICR that are important in the regulation of imprinted genes ... "Genetic and Haplotype Diversity Among Wild-Derived Mouse Inbred Strains". Genome Research. 14 (10a): 1880-1887. doi:10.1101/gr. ... Genetic and haplotype diversity among wild-derived mouse inbred strains. Genome Research, 2004 Oct;14:1880-1887. PMID 15466288 ...
We and others have shown that low-dose X or gamma irradiation of mice leads to an increase in their survival after a subsequent ... Mice, Inbred BALB C * Mice, Inbred ICR * T-Lymphocytes / cytology * T-Lymphocytes / immunology ... We and others have shown that low-dose X or gamma irradiation of mice leads to an increase in their survival after a subsequent ... Nevertheless, we found that PFCs were increased 2 weeks after 50 cGy irradiation, which is the same time at which mice ...
Mice, Inbred C57BL * Mice, Inbred ICR * Mice, Knockout * Mice, Transgenic * Neoplasm Metastasis ... transgenic mouse model of prostate cancer. Mice lacking fgfr1, in prostate cells developed smaller tumors that also included ... Consistent with these phenotypes, mice carrying the fgfr1 null allele survived significantly longer than those without fgfr1 ...
1.1 Mice. 1.2 Rats. 2. Laboratory codes. 3. Inbred Strains and Hybrids. 3.1 Definition 3.2 Nomenclature of Inbred Strains. 3.3 ... Tac:ICR. The ICR outbred stock maintained by Taconic Farms, Inc.. Hsd:NIH Swiss The NIH Swiss outbred stock maintained by ... Recombinant inbred strains: use in gene mapping. In Origins of Inbred Mice, Morse, HC. (eds.), Academic Press, New York, pp. ... Nomenclature for inbred strains of mice preserved by freezing. Mouse News Lett 54:2-3. Committee on Standardized Genetic ...
Mice. Mice, Inbred ICR. Motor Activity / drug effects. Orchidaceae*. Pentobarbital / pharmacology. Phytotherapy*. Picrotoxin / ...
The toxic interaction of caffeine and phenytoin during pregnancy was investigated in mice of the ICR strain on E10 of gestation ... Mice. Mice, Inbred ICR. Phenytoin / toxicity*. Pregnancy. Teratogens*. Chemical. Reg. No./Substance: 0/Teratogens; 57-41-0/ ... The toxic interaction of caffeine and phenytoin during pregnancy was investigated in mice of the ICR strain on E10 of gestation ...
ICR outbred mice. Harlan. Hsd:ICR (CD-1). This strain is also known as CD-1. ... FVB inbred mice. The Jackson Laboratory. 1800. 5-6 weeks of age. ... SS-mouse. High fat rodent chow. Purina Mills. PicoLab Mouse ... 이러한 구조는 AAV8에 패키지 및 신생아 (P0) ICR 마우스의 좌우 심실에 주입 하였다. 높은 바이러스 역가 (반구 당 10 10 입자) (왼쪽 그림 1A) 밀도 후각 망울의 라벨, 선조체, 대뇌 피질, 해마와 ... 우리는 때문에 육성을 위해 ICR 또는 FVB 추천그들은 충분한 우유를 생산하고 쉽게 자신의 쓰레기에 대한 새로운 새끼를 받아들입니다. 그것은 어머니 중단 전에 최소화과 스트레스로 주사 후 그녀가 거부하거나 새끼를 잠식 될 수 ...
Mice Mice, Inbred ICR Pichia Rats Recombinant Fusion Proteins Research Design Serum Albumin ...
Nicotine attenuates DOI-induced head-twitch response in mice: implications for Tourette syndrome. - Y Tizabi, L T Russell, M ... Mice, Inbred ICR. *Nicotine (pharmacology, therapeutic use) *Nicotinic Agonists (pharmacology, therapeutic use) ... in male albino ICR mice were evaluated. Both acute and chronic nicotine (daily injections for 10 days) reduced the DOI-induced ... Nicotine attenuates DOI-induced head-twitch response in mice: implications for Tourette syndrome.. Abstract. Tourette syndrome ...
Pioglitazone attenuates tactile allodynia and thermal hyperalgesia in mice subjected to peripheral nerve injury. - Takehiko ... Mice. *Mice, Inbred ICR. *PPAR gamma (agonists, metabolism) *Pain Measurement. *Posterior Horn Cells (drug effects, metabolism ... Mice were subjected to partial sciatic nerve ligation (PSL) and given pioglitazone (1 - 25 mg/kg, p.o.) once daily. PPARgamma ... Pioglitazone attenuates tactile allodynia and thermal hyperalgesia in mice subjected to peripheral nerve injury.. Abstract. To ...
Noninbred mice are less expensive and include the ICR, Swiss Webster, and NIH lines. Inbred strains of mice are used because of ... most strains of HSV-1 reactivate more readily in inbred BALB/c mice than inbred C57BL/6 mice, which is thought to be caused by ... Several characteristics make mouse models excellent candidates for studying HSV-1. In mice, inbred strains and transgenic ... R. D. Stulting, J. C. Kindle, and A. J. Nahmias, "Patterns of herpes simplex keratitis in inbred mice," Investigative ...
Inbred Strains of Mice: IQI. IQI Inbr ?. Albino c. Origin: Outbred Jcl:ICR mice inbred in 1976 by Y. Yoshimura (Cent. Inst. for ... INBRED STRAINS OF MICE. Updated 9 Apr. 1998. Michael FW Festing. MRC Toxicology Unit, Hodgkin Building,. University of ... Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc ...
A and B). SRKO and 129 mice were injected intraperitoneally with 107 CFU of BCG, or ... Mice. *Mice, Inbred ICR. *Mice, Knockout. *Mycobacterium bovis/immunology. *Receptors, Scavenger. *Scavenger Receptors, Class A ... Figure 5: Production of TNF-α after LPS challenge of SRKO and wild-type (129) mice. (A and B). SRKO and 129 mice were injected ... Figure 5: Production of TNF-α after LPS challenge of SRKO and wild-type (129) mice. (A and B). SRKO and 129 mice were injected ...
These defects make the NOD background a common choice for immunodeficient mouse strains. ,a href=https://www.jax.org/jax-mice- ... for flexible study designs and assay development in mouse models of Lupus. ,strong,,a href=https://www.jax.org/jax-mice-and- ... Diabetes in NOD mice is characterized by hyperglycemia and insulitis, a leukocytic infiltration of the pancreatic islets. ... These mice were originally outbred Jcl:ICR mice. At F6, the progenitors of the future NOD/Shi mice were inbred on the basis of ...
A similar protection from virus mediated mortality was also observed in the inbred C57BL/6J(b) strain. The two inbred mouse ... Data presented in Table 2 below, shows that βAED protects the host ICR inbred strain (Inst. of Cancer Research strain now ... DHEA to SWRJ and C57BL6J inbred mice. The mice were then challenged with varying amounts of Coxsackievirus B4 (CB4) to ... SWR/J inbred mice were injected with single depo doses of 0.5, 2.0, 4.0 and 8.0 mg/animal of βAED, then challenged with 107 PFU ...
... and expression patterns of AAV with different serotypes or promoters in hair cells and supporting cells in the neonatal mouse ... and expression patterns of AAV with different serotypes or promoters in hair cells and supporting cells in the neonatal mouse ... Since ICR mice have better maternity and stronger fertility than C57BL/6J mice, we used ICR mice for the in vivo experiments. ... C57BL/6J is the most widely used inbred strain and the first to have its genome sequenced1. This strain is homozygous for Cdh23 ...
For all experiments, we used inbred ICR mouse strains obtained from Japan SLC (Hamamatsu, Japan). Noon of the day of vaginal ... 1973). Time of origin of neurons in the brain stem of the mouse. Prog. Brain Res. 40, 53-65. doi:10.1016/S0079-6123(08)60679-2 ... In mice, the peak of LRN/ECN neuron generation is around E12, that of PN neurons is around E12-14, and that of ION neurons is ... 2006). 140 mouse brain proteins identified by Ca2+-calmodulin affinity chromatography and tandem mass spectrometry. J. Proteome ...
... inbred mice during chronic nicotine infusion (24 mg/kg/day) or saline for 14 days. Mice received an acute s.c. injection of ... Male ICR mice (20-25 g) obtained from Harlan (Indianapolis, IN) were used throughout the study. Male C57/BL/6J and 129/SvEv ... The withdrawal severity of nicotine differs between C57/BL and 129/SvEv inbred mice with nicotine withdrawal in C57 being more ... Our results with two different inbred mouse strains extend previous observations that genetic factors influence the development ...
Studies performed in mice indicated that the peripheral pathogenicity of LBV had been underestimated in previous studies. ... variant, isolated in Washington, USA, 2004), were injected into 4-week-old inbred ICR mice (5 mice/group) by different routes. ... Thereafter, 4-week-old ICR mice were injected with 30 μL of 103 LD50 of each virus by the i.c. route and 30 μL of 105 LD50 of ... The i.c. 50% lethal dose (LD50) was determined by titration of the virus suspension injected into 4-week-old ICR mice by the i. ...
Spontaneous hepatomas in mice inbred from Ha:ICR swiss stock: Effects of sex, cedar shavings in bedding, and immunization with ... inbred mice (International Committee on Standardized Genetic Nomenclature for Mice 1981 a,b,c), and transgenic animals (NRC ... Rules for the nomenclature of inbred strains. Pp.368-372 in Genetic Variants and Strains of the Laboratory Mouse, M. C. Green. ... Identification and genetic monitoring of mouse inbred strains using biomedical polymorphisms. Lab. Anim. (London) II(4):209-214 ...
An inbred C57BL6 strain of mice was resistant to the mucin-bacterial combination. Mucin, treated with Desferal to chelate the ... The enhancement of streptococcal virulence was measured by a significantly increased mortality in outbred ICR Swiss mice. ... type III streptococci in ICR Swiss mice. Iron-dextran was not a suitable substitute for mucin and failed to enhance the ... Mucin model for group B type III streptococcal infection in mice. Message Subject (Your Name) has forwarded a page to you from ...
... and testes frozen and transported internationally to another laboratory by air could produce pups of inbred C57BL/6 mice. ... ICR and C57BL/6). Epididymides ... We tested whether mouse male germ cells could be cryopreserved ... Testicular spermatozoa retrieved from the bodies of male mice (BALB/c nude and C3H/He strains) that had been kept frozen (-20°C ... Researchers have frozen male mice or just their testes, and found out that the preserved sperm is as good as new. The last ...
... mice.Immunohistochemical staining for ICAM-1 was performed in the cortex ti ... b)Injured Nrf2 (+/+) mice showing increased number ofICAM-1 positive vessels. (d) Injured Nrf2 (−/−) mice showing larger ... b)Injured Nrf2 (+/+) mice showing increased number ofICAM-1 positive vessels. (d) Injured Nrf2 (−/−) mice showing larger ... mice than in Nrf2 (+/+) mice. Datarepresents mean ± SEM (n = 5 per group). **P , .01 versus sham control of the same genotype ...
ICR × SW) F1 hybrid mice revealed that male offspring displayed an ICR-like phenotype and female offspring displayed a SW-like ... mice. The same workers have recently (40) identified μ-, δ-, and κ-type heroin responders among inbred mouse strains. Vaccarino ... 1978) in Origin of Inbred Mice, ed Morse H C III(Academic, New York), pp 423-428. ... We recently tested 11 inbred strains on 12 separate measures of nociception in common use in the mouse (59, 60). The assays ...
1995) were obtained from strain ICR mice. Consistent with this hypothesis, the leucine that we noted at position 5 is present ... because our data were obtained from inbred C57BL/6J mice, and the first 257 residues reported by Burgess et al. ( ... The mouse Scn8a sodium channel and its ortholog Na6 in the rat are abundantly expressed in the CNS. Mutations in mouse Scn8a ... Functional Analysis of the Mouse Scn8a Sodium Channel. Marianne R. Smith, Raymond D. Smith, Nicholas W. Plummer, Miriam H. ...
Inbred BALB/cAnNHsd and random-bred ICR pathogen-free female mice (Hsd:ICR[CD-1]), aged 6-8 weeks, were purchased from Harlan ... Two weeks after last immunization mice were infected with PyL and mouse number survived the infection and mouse number lived ... Purification of Mouse IgGs. Hsd:ICR (CD-1) malaria-resistant mice were generated as previously described by Azcárate et al. [20 ... Briefly mice were infected intraperitoneally with 2 × 107 PyL-iRBCs obtained from donor PyL-infected mice. Mice that recovered ...
4 classical inbred strains (ALS/LtJ, ALR/LtJ, CHMU/LeJ and NU/J), 1 line derived from the ICR:HsD outbred stock (HR8; Swallow ... Inbred strains:. Sequencing data for inbred strains of mice except ZALENDE/EiJ and LEWES/EiJ were obtained from the Sanger ... 2 wild-derived inbred strains, and 22 classical inbred strains of mice with a diploid R2d copy number of two. We first defined ... The mouse reference genome (strain C57BL/6J, M. m. domesticus) contains a single copy of R2d at R2d1. Wild-derived inbred ...
Apr, 2004 , Pubmed ID: 15133273 The ICR-derived glomerulonephritis (ICGN) mouse, a new inbred mouse strain with a hereditary ... Jul, 2004 , Pubmed ID: 15297765 The ICR-derived glomerulonephritis (ICGN) mouse, a novel inbred mouse strain with a hereditary ... Apr, 2005 , Pubmed ID: 15897628 ICR-derived glomerulonephritis (ICGN) mice are a novel inbred strain with hereditary nephrotic ... The ICR-derived glomerulonephritis (ICGN) mouse, a new hereditary nephrotic mouse, is an appropriate model of anemia associated ...
... mice, inbred dba MeSH B01.050.157.520.480 - mice, inbred hrs MeSH B01.050.157.520.510 - mice, inbred icr MeSH B01.050.157.520. ... mice, inbred dba MeSH B01.050.199.520.520.480 - mice, inbred hrs MeSH B01.050.199.520.520.510 - mice, inbred icr MeSH B01.050. ... mice, inbred a MeSH B01.050.157.520.318 - mice, inbred akr MeSH B01.050.157.520.338 - mice, inbred balb c MeSH B01.050.157.520. ... mice, inbred a MeSH B01.050.199.520.520.318 - mice, inbred akr MeSH B01.050.199.520.520.338 - mice, inbred balb c MeSH B01.050. ...
... strains of inbred and non-inbred male mice: Strain LD50 (mg/kg b.w.) DBA/2N (inbred) 138 BALB/cNnN (inbred) 1739 C57BL/6N ( ... inbred) 917 ICR-JCL (non-inbred) 1243 In all cases, death occurred 4 to 6 days after administration of BHT, and was accompanied ... Mice Groups of male and female C3H mice (ranging from 17-39 mice/group), which were 6-10 weeks old at the beginning of the ... Mice maintained on diets containing BHT had lower body weights than controls. Male mice fed BHT showed an increase in liver ...
  • Here, we developed an i mproved-PITT ( i -PITT) method by combining Cre- lox P, PhiC31- attP / B and FLP- FRT systems directly under C57BL/6N inbred strain, unlike the mixed strain used in previous reports. (biomedcentral.com)
  • The i -PITT system offers several advantages compared to previous methods: multiplexing capability ( i -PITT is the only targeted-transgenic method that is proven to generate multiple different transgenic lines simultaneously), very high efficiency of targeted-transgenesis (up to 62%), significantly reduces animal numbers in mouse-transgenesis and the system is developed under C57BL/6N strain, the most commonly used pure genetic background. (biomedcentral.com)
  • Presently, we examined the presence, source and clinical correlations of IL-22 in human SjS patients and in the C57BL/6.NOD-Aec1R1Aec2 mouse model. (ufl.edu)
  • Interestingly, in the C57BL/6.NOD-Aec1R1Aec2 mouse model (currently considered one of the most phenotypically similar to the human disease) minimal to no IL-22 was present within the salivary or lacrimal glands, and levels present within the spleen, thymus, and lymph nodes were comparable to that of C57BL/6 controls. (ufl.edu)
  • Methods: To investigate whether low-dose BPA exposure in the fetal stage can alter CpG methylation levels in the central nervous system, the hippocampus of the inbred C57BL/6 J mouse as the target tissue was collected to detect alterations in CpG methylation levels using a highly sensitive method of genome-wide DNA methylation analysis, methylated site display-amplified fragment length polymorphism (MSD-AFLP). (deepdyve.com)
  • Black 6 (according to the nomenclature C57BL / 6) inbred mouse model used in atherosclerosis research, metabolism, carcinogenesis, immunology, research in infectious diseases. (velaz.cz)
  • C57BL/6J mice with inherited retinal degeneration. (springer.com)
  • Spontaneous, asymmetrical microphthalmia in C57Bl/6J mice. (springer.com)
  • In this study, we investigated the underlying genetic profiles of a newly developed mouse strain, C57BL/6NKorl (Korl), established through sibling mating over 30 generations. (bvsalud.org)
  • To analyse the distinctive genomic features of Korl mice, we used whole-genome sequencing from six samples, which were compared to those of other C57BL/6N-based mouse strains. (bvsalud.org)
  • Here we describe differences in the cortical area map of two commonly used inbred strains of laboratory mice, C57BL/6J and DBA/2J. (beds.ac.uk)
  • The sample of C57BL/6J and DBA/2J mice can be discriminated with 90% accuracy on the basis of these three size dimensions. (beds.ac.uk)
  • C57BL/6J and DBA/2J have markedly different cortical area maps, suggesting that inbred strains harbor enough phenotypic variation to encourage a forward genetic approach to understanding cortical development, complementing other approaches. (beds.ac.uk)
  • Strain and sex differences in anxiety-like and social behaviors in C57BL/6J and BALB/cJ mice. (zoores.ac.cn)
  • Differences in drug-induced place conditioning between BALB/c and C57Bl/6 mice. (zoores.ac.cn)
  • [email protected]#To explore the effect of oxidative stress on periprosthetic osteolysis induced by TCP wear particles in mouse calvaria and its mechanism. (bvsalud.org)
  • including C. krusei, C. albicans, C. tropicalis, and C. lusitaniae with MICs ranging from 3.1 to 25 μg/ml. 7-Oxostaurosporine demonstrated no in vivo toxicity in SPF ICR mice. (elsevier.com)
  • Mukaratirwa S, Petterino C, Naylor SW, Bradley A. Incidences and range of spontaneous lesions in the eye of Crl:CD-1(ICR)BR mice used in toxicity studies. (springer.com)
  • In this study, we report the evaluation of a tissue-specific conditional deletion mutant generated in an ARR2PBi(Pbsn)-Cre/TRAMP/fgfr1(loxP/loxP) transgenic mouse model of prostate cancer. (nih.gov)
  • In particular, a mouse model offers several possibilities for exploring the underlying mechanisms of nicotine dependence and abstinence by using the transgenic and genetic mouse models available along with the pharmacological and biochemical approaches. (aspetjournals.org)
  • The pronuclear injection (PI) is the simplest and widely used method to generate transgenic (Tg) mice. (biomedcentral.com)
  • Transgenic (Tg) mice have been extensively used for in vivo analysis of gene function and generation of human disease models. (biomedcentral.com)
  • transgenic ES cells and mice demonstrates the developmental neutrality of mRFP1 in an organismal context. (biomedcentral.com)
  • 5 ] demonstrated changes in the position and or size of primary sensory visual, somatosensory, and auditory cortical regions in transgenic mice over expressing the transcription factor Emx2 . (beds.ac.uk)
  • We thereby created an allelic series of embryonic stem cells and mice, each containing a signal-responsive sentinel with different fluorescent reporters that respond with sensitivity and specificity to retinoic acids, bone morphogenic proteins, activin A, Wnts or Notch, and that can be adapted to any pathway that acts via DNA elements. (biologists.org)
  • Inbred and outbred mice were immunized with various recombinant P. falciparum MSP1 42 proteins that represent the two major alleles of MSP1 42 , MAD20 (3D7) and Wellcome (K1, FVO). (biomedcentral.com)
  • In this study, the effects of acute and chronic administration of nicotine on DOI-induced head twitch response (HTR) in male albino ICR mice were evaluated. (curehunter.com)
  • Male mice are useful for certain applications, including pharmaceutical studies, "accelerated transfer" of IDDM, and some in vitro studies. (jax.org)
  • Adenovirus-mediated Gene Delivery and in Vitro Microinsemination Produce Offspring from Infertile Male Mice Proceedings of the National Academy of Sciences of the United States of America. (jove.com)
  • BIOLOGICAL DATA Biochemical aspects Metabolism A single oral dose of 14 C-BHT given to male and female mice resulted in rapid absorption and distribution of 14 C to the tissues. (inchem.org)
  • 1984). Dietary administration of BHT to male Swiss Webster mice resulted in a marked increase in hepatic microsomal epoxide hydrolase and glutathione-S-transferase (Hammock & Ota, 1983). (inchem.org)
  • Toxicological studies Special studies on carcinogenicity Mice Groups of male and female C 3 H mice (ranging from 17-39 mice/group), which were 6-10 weeks old at the beginning of the experiment, were maintained for 10 months on a semi-synthetic diet containing 0.05 or 0.5% BHT. (inchem.org)
  • Male mice fed BHT showed an increase in liver tumours, compared to controls. (inchem.org)
  • The reported incidence of liver tumours in male C 3 H mice was 10/26 (38%), 15/26 (58%), 2/37 (5%) and 7/38 (18%) in the 0.5% BHT, 0.05% BHT, control BHT-free, and control lab chow groups, respectively. (inchem.org)
  • In a study in which C 3 H mice were maintained on diets containing 0.5% BHT for one month followed by lab chow for 10 months, or control diet (BHT-free) for one month followed by lab chow for 10 months, the incidences of liver tumours in the two groups of male mice were 3/35 (9%) and 5/29 (17%), respectively. (inchem.org)
  • Dietary BHT did not result in an increased incidence of lung tumours in either male or female C 3 H mice. (inchem.org)
  • In another study in which male BALB/c mice were maintained for one year on a BHT-free diet, or diets containing 0.05% BHT or 0.5% BHT, the incidences of liver tumours were 4/30 (131), 6/43 (14%), and 2/28 (7%) for the respective groups (Lindenschmidt et al . (inchem.org)
  • ICR male mice were divided into 6 experimental groups that intra-tracheally received the vehicle, two types of CNT (4 mg/kg), LPS (33 ig/kg), or LPS plus either type of CNT. (elsevier.com)
  • Both male (n=3) and female (n=3) mice were examined at time points 4, 8, 12, 16, 20, and 24 wks. (ufl.edu)
  • Male mice were divided into a control and experimental groups treated with purified MiMo at 3 doses of 15, 30, and 60 mg/KgBW, respectively for 35 consecutive days. (bvsalud.org)
  • [email protected]#Male ICR mice at 4 weeks of age were orally administered IDPN in saline (28 mmol/kg body weight) once. (bvsalud.org)
  • In this study, we examined the involvement of the cytokine IL-1β, the transcription factor nuclear factor kappa B (NF-κB), and de novo protein synthesis in the development of allodynia induced by intrathecal (i.t.) administration of dynorphin in male ICR mice. (elsevier.com)
  • Development of tolerance to phencyclidine (PCP) was assessed in male ICR mice, using motor incoordination as a parameter. (elsevier.com)
  • In this study, ICR male mice were fed a high-fat diet (HFD) in vivo and the AML12 cells were treated with palmitic acid (PA) in vitro. (illinois.edu)
  • Previously, we reported that 17β-estradiol (E2) inhibits azoxymethane/dextran sulfate sodium (AOM/DSS)-induced tumorigenesis in male mice. (elsevierpure.com)
  • We established four groups of mice based on the sex and estrogen status [ovariectomized (OVX) female and E2-treated male]. (elsevierpure.com)
  • In normal physiological condition, sex difference and E2 treatment did not affect the ratio of Firmicutes/Bacteroidetes (F/B). However, in AOM/DSS-treated male mice, E2 supplementation showed significantly lower level of the F/B ratio. (elsevierpure.com)
  • [email protected]#Thirty-six male ICR mice were randomly divided into three groups (=12)sham group, TCP wear particles (TCP) group and N-acetyl-L-cysteine (NAC) group. (bvsalud.org)
  • In this study, we used mice lacking the SR-A (SRKO) to investigate the role of SR-A in acquired immunity using a viable bacillus Calmette Guérin (BCG) infection model. (nih.gov)
  • After BCG infection, SRKO mice are able to recruit Mphi to sites of granuloma formation where they become activated and restrict BCG replication. (nih.gov)
  • At 14 d after infection, mice were injected with 10 μg of LPS intraperitoneally. (nih.gov)
  • Mucin model for group B type III streptococcal infection in mice. (asm.org)
  • The humoral response allowed delay of the infection after the inoculation to high lethal doses of P. yoelii yoelii 17XL resulting in a partial protection against malaria disease, although final survival was managed in a low proportion of challenged mice. (hindawi.com)
  • Nevertheless, enhanced expressions of NDAF, persistent UPS impairment and excess amyloid β (Aβ) accumulation concomitantly emerged in the experimental mice hippocampus at 8, 16 and 20 weeks post-infection. (biomedcentral.com)
  • This is the first study to demonstrate experimentally that infection with H. bilis causes IBD in scid mice with defined flora. (asm.org)
  • Persistent infection with mouse hepatitis virus, JHM strain in DBT cell culture. (utmb.edu)
  • In this study, we analyzed innate immune responses to hantavirus infection in vitro in human astrocytic cells (A172) and in vivo in suckling ICR mice. (elsevier.com)
  • Although LDV infection generally does not cause disease, infected mice that are homozygous for the Fv1 n allele are prone to develop poliomyelitis when immunosuppressed, a condition known as age-dependent poliomyelitis. (elsevier.com)
  • Mice presenting within the first 6 mo after infection had regions of spongiosis, neuronal necrosis and astrocytosis of the ventral spinal cord, and less commonly, brainstem. (elsevier.com)
  • In addition, the use of new drugs in the therapy of a parasitic infection, trypanosomiasis (Chagas' disease), is being studied in vitro and in mice. (stanford.edu)
  • The purpose of the present study is to understand the function of the Clock gene during lipid metabolism in the liver using Clock-mutant mice. (elsevier.com)
  • Mice and rats used in the laboratory derive from a variety of sources. (jax.org)
  • It has been proposed that twitches of the head in mice or twitches of head and shoulders in rats following administration of the selective 5HT(2A/C) agonist DOI (1-)2,5-dimethoxy-4-iodophenyl-2-aminopropane, can serve as an animal model of tics in TS. (curehunter.com)
  • More than 43 metabolites were present in the urine and faeces of mice and rats (Matuso, 1984). (inchem.org)
  • Results indicated although there were insignificant differences in learning and memory function between the experimental mice and uninfected control mice, possibly because the site where T. canis larvae invaded was the surrounding area but not the hippocampus per se. (biomedcentral.com)
  • Does the prenatal bisphenol A exposure alter DNA methylation levels in the mouse hippocampus? (deepdyve.com)
  • A variety of mutations causing immunodeficiencies, targeted mutations in cytokine genes, as well as transgenes affecting immune functions, have been backcrossed into the NOD/ShiLt inbred strain background. (jax.org)
  • Since regulation of imprinted genes was thought to be governed by the epigenetic modifications to the imprinting control region (ICR), Ideraabdullah explored whether there are regions outside the ICR that are important in the regulation of imprinted genes. (wikipedia.org)
  • 6 ] have employed gene expression array analysis of the dissected embryonic (16.5d) mouse cerebral cortex to expand the list of genes regionally expressed, and noted that regional differences in expression of genes in the cortical plate should eventually convert into functionally distinct cortical areas with anatomically distinguishable borders after birth. (beds.ac.uk)
  • We tested the precision of coregulation of numbers of neurons, glial cells, and endothelial cells in the dorsal lateral geniculate nucleus (LGN) in 58 isogenic strains of mice. (jneurosci.org)
  • To examine the functional characteristics of this channel, we constructed a full-length cDNA clone encoding the mouse Scn8a sodium channel and expressed it in Xenopus oocytes. (jneurosci.org)
  • GABA-activated chloride channels were also studied in Xenopus oocytes expressing mouse brain mRNA. (muscimol.xyz)
  • An inbred C57BL6 strain of mice was resistant to the mucin-bacterial combination. (asm.org)
  • Our preclinical efficacy testing services offer scientific expertise and an array of target-based and phenotype-based outcome measures, both in vivo and at endpoint, for flexible study designs and assay development in mouse models of Lupus. (jax.org)
  • In order to better understand the in vivo function of IL-22, a mouse model is needed which mimics similar overexpression patterns to human SjS patients. (ufl.edu)
  • To assess whether HSF1 exhibited redundant or unique in vivo functions, we created Hsf1 −/− deficient mice. (embopress.org)
  • To determine the pathogenic potential of H. bilis, we inoculated 4-week-old female Tac:Icr:Ha(ICR)-scidfDF mice by intraperitoneal injection of approximately 10(8) CFU of H. bilis in phosphate-buffered saline (PBS) (n = 15) or PBS alone (n = 10) and necropsied them at 7 weeks postinfection. (asm.org)
  • Following intraperitoneal inoculation with HTNV or MJNV, suckling ICR mice developed rapidly progressive, fatal central nervous system-associated disease. (elsevier.com)
  • We used the sera of malaria self-resistant ICR mice to lethal Plasmodium yoelii yoelii 17XL for purification of their IgGs which were subsequently employed to isolate blood-stage parasite antigens that were inoculated to immunize BALB/c mice. (hindawi.com)
  • We also examined thymocyte apoptosis and spleen PFCs in mice subjected to other stress-inducing pretreatments. (nih.gov)
  • CBR1 has been shown to be the major reductase in mouse kidney, spleen, and heart (6) , but is produced at a low level in every tissue examined (data not shown). (aacrjournals.org)
  • Materials and Methods: The mice were divided into four different groups and received the test extracts and the standard drug (aspirin) for 14 days via force-feeding. (afpm.org.my)
  • Origin: Outbred Jcl:ICR mice inbred in 1976 by Y. Yoshimura (Cent. (jax.org)
  • Widespread use of DsRed has been hampered by several issues resulting in the inability to establish and maintain lines of red fluorescent protein expressing embryonic stem cells and mice. (biomedcentral.com)
  • We have used embryonic stem cell-mediated transgenesis to evaluate mRFP1 in embryonic stem cells and mice. (biomedcentral.com)
  • 2 Very similar diseases occur in lab mice with essentially the same mutations. (icr.org)
  • Inbreeding accumulates mutations in humans and animals today, so it makes sense to look to those same culprits to explain human and animal problems of the past. (icr.org)
  • Consistent with these phenotypes, mice carrying the fgfr1 null allele survived significantly longer than those without fgfr1 deletion. (nih.gov)
  • Otherwise, there are no significant differences among the biological phenotypes of Korl:ICR and other ICR. (bvsalud.org)
  • Also, we confirmed that there is no difference among the Korl:ICR and other ICR on biological phenotypes. (bvsalud.org)
  • This study examined the effects of pulmonary exposure to two types of nano-sized materials (carbon nano-tubes: CNT [single-wall: SWCNT, and multi-wall: MWCNT]) on lung inflammation and consequent systemic inflammation with coagulatory disturbance induced by pulmonary exposure to LPS in mice and their cellular mechanisms in vitro. (elsevier.com)
  • Bud formation precedes the appearance of differential cell proliferation during branching morphogenesis of mouse lung epithelium in vitro. (nih.gov)
  • Since xCT is a specific subunit of Sxc, we employed xCT knockout mice and investigated whether this antiporter affected methamphetamine (MA)-induced dopaminergic neurotoxicity. (fujita-hu.ac.jp)
  • 1986). It has previously been demonstrated that the incidence of spontaneously-occurring hepatic tumours in C 3 H mice is modified by sex, population density, level of dietary protein, and caloric intake. (inchem.org)
  • Mice with one functional copy of the gene ( Cbr1 +/−) were healthy and grossly normal despite having decreased levels of Cbr1 transcript and protein. (aacrjournals.org)
  • RESULTS: In the mouse, RFC transcripts and protein are expressed in the E10.0 placenta and yolk sac. (openrepository.com)
  • Muscimol-stimulated 36Cl- uptake was studied in mouse brain microsacs permeabilized to introduce the catalytic subunit of cAMP-dependent protein kinase (PKA). (muscimol.xyz)
  • Using indirect immunofluorescence on cryosections, we characterized the changes in protein localization of alpha 1 to 6 chains of type IV collagen during molar development in mice molar and human tooth germ. (elsevier.com)
  • coral holds much promise as a genetically and spectrally distinct alternative to green fluorescent protein (GFP) for application in mice. (biomedcentral.com)
  • An Automated Method To Predict Mouse Gene and Protein Sequences Using Variant Data. (harvard.edu)
  • Nicotine attenuates DOI-induced head-twitch response in mice: implications for Tourette syndrome. (curehunter.com)
  • The nicotine withdrawal syndrome was validated and characterized in the mouse using both somatic and affective measures after infusion with nicotine daily via subcutaneous minipumps. (aspetjournals.org)
  • The withdrawal severity of nicotine differs between C57/BL and 129/SvEv inbred mice with nicotine withdrawal in C57 being more severe than in the 129 strain. (aspetjournals.org)
  • The present study demonstrates that our mouse nicotine withdrawal model will be useful for studying the pharmacological, biochemical, and genetic mechanisms involved in nicotine dependence. (aspetjournals.org)
  • Most laboratory mice have contributions from both Mus musculus musculus and Mus musculus domesticus . (jax.org)
  • We have reconstructed the origin and history of a 127-kbp segmental duplication, R2d , in the house mouse ( Mus musculus ). (genetics.org)
  • This guideline is reviewed annually by the international nomenclature committees for mouse and rat and updated as required. (jax.org)
  • Production of inbred strains means that these backgrounds can be defined and thus require nomenclature conventions. (jax.org)
  • A key feature of mouse and rat nomenclature is the Laboratory Registration Code or Laboratory code, which is a code of usually three to four letters (first letter uppercase, followed by all lowercase) that identifies a particular institute, laboratory, or investigator that produced, and may hold stocks of, a mouse or rat strain. (jax.org)
  • We have previously shown that, in the absence of mesenchyme, fibroblast growth factor 1 (FGF-1) elicits budding of the mouse lung epithelium cultured in a basement membrane matrix. (nih.gov)
  • Here we describe the occurrence of poliomyelitis in ICR-SCID mice resulting from injection of LDV-contaminated basement membrane matrix. (elsevier.com)
  • Nrf2 (-/-) mice were shown to have more NF-kappaB activation, inflammatory cytokines TNF-alpha, IL-1beta and IL-6 production, and ICAM-1 expression in brain after TBI compared with their wild-type Nrf2 (+/+) counterparts. (nih.gov)
  • e) Quantitative analysis showed that the number of ICAM-1positive vessels in brain was significantly increased after TBI and was greaterin Nrf2 (−/−) mice than in Nrf2 (+/+) mice. (nih.gov)
  • The brain-to-blood ratios in normal ICR mice were 2.8 or greater at the times studied, and the striatum-to-cerebellum ratio at 60 min after injection was 20:1. (elsevier.com)
  • Long-term residence of T. canis larvae in a paratenic host's brain may cause cerebral toxocariasis (CT) that contributes to cerebral damage, neuroinflammation and neuropsychiatric disorders in mice and clinical patients. (biomedcentral.com)
  • Cells were counted using unbiased counting protocols and tissue from the Mouse Brain Library ( www.mbl.org ). (jneurosci.org)
  • Temperature sensitive (TS) mutant, defective interfering (DI) particle or interferon was not detected in the JHM-CC. To intracerebral inoculation with JHM-CC virus, cortisone treated ICR mice survived without showing clinical signs, however, demyelinating lesions were produced in the brain and spinal cord of them. (utmb.edu)
  • Flow cytometry was used to further characterize these populations in mice. (ufl.edu)
  • CPG or sulfasalazine significantly attenuated MA-induced TUNEL-positive cell populations in the striatum of Taconic ICR mice. (fujita-hu.ac.jp)
  • In the E9.0 to E11.5 mouse embryo RFC is widely detectable, with intense signal localized to cell populations in the neural tube, craniofacial region, limb buds and heart. (openrepository.com)
  • 7 Their original populations may well have died off alongside the mammoths due to inbreeding. (icr.org)
  • Therefore, they should not be referred to by species name, but rather as laboratory mice or by use of a specific strain or stock name. (jax.org)
  • In addition, some recently developed laboratory mouse strains are derived wholly from other Mus species or other subspecies, such as M. spretus ). (jax.org)
  • Spontaneous corneal opacities in laboratory mice. (springer.com)
  • Therefore, the Korl:ICR source colony might be a new stock in distinction from other ICR, it is a good milestone in securing ownership of the national laboratory animal resource. (bvsalud.org)
  • Inbred strains of laboratory mice can be exploited to study cortical area map formation if there are significant phenotypic differences with which to correlate gene polymorphism or expression data. (beds.ac.uk)
  • Significantly higher levels of TNF-α were present in the plasma of SRKO mice relative to wild-type mice (Fig. 5 A). To confirm that the measured differences in this cytokine were not confounded by differences in response to viable microorganisms, mice were injected with inactivated C. parvum and subsequently challenged with LPS. (nih.gov)
  • 05 versus injured wild-type mice. (nih.gov)
  • Within 2 weeks, 91% of wild-type mice were severely affected ( n = 11) compared with 18% of Cbr1 +/− mice ( n = 11). (aacrjournals.org)
  • However, these mice exhibit CBR1 activity at 470-fold higher levels than wild-type mice, and, thus, do not reflect physiological conditions. (aacrjournals.org)
  • MA treatment significantly increased striatal oxidative burdens in wild type mice. (fujita-hu.ac.jp)
  • Triglyceride content in the liver was significantly less increased in Clock-mutant mice on a high-fat diet compared to wild-type mice on a high-fat diet. (elsevier.com)
  • Acsl4 and Fabp1 mRNA levels in the liver showed daily rhythms in wild-type mice. (elsevier.com)
  • In contrast, Clock -mutant mice had attenuated daily rhythms of Acsl4 and Fabp1 gene expression in the liver under both normal and high-fat diet conditions compared to wild-type mice. (elsevier.com)
  • In Clock-mutant mice, suppression of Acsl4 and Fabp1 mRNA in the liver under high-fat diet conditions may have attenuated the accumulation of triglycerides in the liver compared to wild-type mice under the same conditions. (elsevier.com)
  • In conclusion, the authors demonstrate that mice with a Clock mutation showed less triglyceride accumulation in the liver through the suppression of Acsl4 and Fabp1 gene expression when fed a high-fat diet compared to wild-type mice fed the same diet. (elsevier.com)
  • Helicobacter bilis-induced inflammatory bowel disease in scid mice with defined flora. (asm.org)
  • Helicobacter bilis has been isolated from aged inbred mice with multifocal chronic hepatitis and from scid mice with diarrhea, proliferative typhlitis, and colitis. (asm.org)
  • In addition, LDV-induced poliomyelitis has not been reported in SCID or ICR mice. (elsevier.com)
  • ICR mouse embryos (detection of vaginal plug: day 0) and newborn mice were used. (elsevier.com)
  • We have used various optical imaging modalities to visualize mRFP1 expressing cells in culture, in embryos and adult mice. (biomedcentral.com)
  • The enhancement of streptococcal virulence was measured by a significantly increased mortality in outbred ICR Swiss mice. (asm.org)
  • Mucin, treated with Desferal to chelate the iron, did not lose the capacity to enhance the virulence of group B, type III streptococci in ICR Swiss mice. (asm.org)
  • The effect of dietary beta carotene on colon carcinogenesis Induced by 1,2-dimethylhydrazine «DMH) CAS: 540-73-81 was studied in female inbred Swiss Webster (ICR) mice. (athabascau.ca)
  • Female, Swiss mice were fed semi-synthetic diets for 33 days. (athabascau.ca)
  • The influence of dietary selenium and cabbage on the formation of colon tumors in female Swiss mice treated with 1,2.dimethylhydrazine [(DMH) CAS: 540-73-8] was reported. (athabascau.ca)
  • Hubert M, Gerin G, Durand-cavagna G. Spontaneous ophthalmic lesions in young swiss mice. (springer.com)
  • Pioglitazone attenuates tactile allodynia and thermal hyperalgesia in mice subjected to peripheral nerve injury. (curehunter.com)
  • Dynorphin A is an endogenous opioid peptide, which has previously been shown to produce a long-lasting allodynia and hyperalgesia in mice, behavioral states consistent with signs of clinically observed neuropathic pain. (elsevier.com)
  • Mice, Inbred Strains" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • Mice in groups I, II, III, IV, and V were given honey at a dose of 10% (v/v), 40% (v/v) and 80% (v/v), dexamethasone 3 mg/kg, and phosphate buffered saline (vehicle) respectively, orally once a day for 5 days of the challenged period. (afpm.org.my)
  • PPARgamma was distributed in the neurons of the dorsal root ganglion and the dorsal horn of the spinal cord and in the adipocytes at the epineurium of the sciatic nerve in naive mice. (curehunter.com)
  • To better understand the role of Ca 2+ -CaM in neuronal migration, we investigated mouse precerebellar neurons (PCNs), which undergo stereotyped, long-distance migration to reach their final position in the developing hindbrain. (biologists.org)
  • 1996 ) found almost no relationship between Purkinje cells and olivary neurons in inbred strains and staggerer mutant mice. (jneurosci.org)
  • In addition, we show that an antibody which blocks TNF-alpha activity reduces LPS-induced mortality in these mice. (nih.gov)
  • We reasoned that this molecule was a candidate mediator of the difference in mortality observed between wild-type and SRKO mice. (nih.gov)
  • Her findings were the first to suggest that mechanisms outside the ICR are necessary to mediate the fully repressed state of an imprinted gene. (wikipedia.org)
  • No increase was observed in female mice. (inchem.org)
  • The evolving technology of global mRNA expression analysis was employed to determine the potential differential expression of ∼3,000 mRNAs between the white quad (white muscle) and the red soleus muscle (mixed red muscle) of female ICR mice (30-35 g). (elsevier.com)
  • These results indicate that female ICR mice are more prosocial and are more susceptible to morphine exposure than males. (zoores.ac.cn)
  • She mutated different regions within the ICR for H19/IGF2 and this caused a loss of repression of the imprinted gene, yet the methylation patterns at the imprinted gene's ICR and promoter region did not change. (wikipedia.org)
  • Mouse is a commonly used animal in life science studies and is classified as outbred if genetically diverse and inbred if genetically homogeneous. (bvsalud.org)
  • These results suggest that as a genetically indigenous source colony, the Korl:ICR is seperated (or independent) stock with other ICR. (bvsalud.org)
  • Her thesis worked explored the genetic architecture of DDK syndrome and the genetic basis for embryonic lethality in mice. (wikipedia.org)
  • Genetic variation and population substructure in outbred CD-1 mice: implications for genome-wide association studies. (springer.com)
  • In inbred mouse lines, there is generally little genetic difference between individuals. (bvsalud.org)
  • Establishment of the genetic profile of Korl mice can provide insight into the inbreeding-induced changes to the gene pool, and help to establish this strain as a useful model for practical and targeted research purposes. (bvsalud.org)
  • A natural mouse model reveals genetic determinants of systemic capillary leak syndrome (Clarkson disease). (harvard.edu)
  • Both mice and human tooth germ, we detected conversions in localization and composition of type IV collagen alpha chains working with tooth germ development. (elsevier.com)
  • One phylogroup consists of Mokola virus and LBV (group II), while all other genotypes are in group I. Members of phylogroup I are reported to be pathogenic for mice when introduced intramuscularly and intracerebrally. (cdc.gov)
  • In contrast, members of phylogroup II are believed to be pathogenic in mice only when introduced by the intracerebral (i.c.) route ( 5 ). (cdc.gov)
  • I. Members of phylogroup I are reported to be pathogenic strategies for LBV in Africa must be improved to better for mice when introduced intramuscularly and intracere- understand the epidemiology of this virus and to make brally. (cdc.gov)
  • In contrast, members of phylogroup II are believed informed decisions on future vaccine strategies because to be pathogenic in mice only when introduced by the evidence that current rabies vaccines provide protection intracerebral (i.c.) route ( 5 ). (cdc.gov)
  • This result both confirms a pathogenic role for H. bilis in mice and provides a new model relating a specific microbial agent and IBD. (asm.org)
  • Astrocyte-enriched cultures were derived from newborn ICR mouse cerebra. (elsevier.com)
  • At the 24 hours after TBI, the number of ICAM-1 positivevessels was significantly increased in the cortex of both Nrf2 (+/+) and Nrf2(−/−) mice. (nih.gov)
  • Mice lacking fgfr1, in prostate cells developed smaller tumors that also included distinct cancer foci still expressing fgfr1 indicating focal escape from gene excision. (nih.gov)
  • Diabetic mice are hypoinsulinemic and hyperglucagonemic, indicating a selective destruction of pancreatic islet beta cells. (jax.org)
  • compared normal Purkinje cells with those from Scn8a null mice. (jneurosci.org)
  • They also identified a resurgent current that was elicited by an action potential-like waveform in normal Purkinje cells, and this current was significantly decreased in cells from Scn8a null mice. (jneurosci.org)
  • In order to develop a mouse model to study the role of this gene during development and disease, we produced a mutation in the mouse ortholog, Tbx3 . (biologists.org)
  • [email protected]#In this study, correlations of cVEMP with scores for balance-related behavior tests including rotarod, beam, and air-righting reflex tests were determined in ICR mice with vestibular disorder induced by 3,3'-iminodipropiontrile (IDPN) as a mouse model of vestibular disorder. (bvsalud.org)
  • This study aimed to investigate the efficacy of Gelam honey on the histopathological changes in the lungs of a mice model of allergic asthma. (afpm.org.my)
  • All histopathological parameters such as epithelium thickness, the number of mast cell and mucus expression in Group III significantly improved when compared to Group VI except for subepithelial smooth muscle thickness (p mice model of allergic asthma. (afpm.org.my)
  • The ICR hydronephrosis mouse is an animal model of hydronephrosis disease in human. (mahidol.ac.th)
  • Following this finding, Ideraabdullah generated and characterized a mouse model of Beckwith-Wiedemann Syndrome (BWS), a disorder caused by aberrations in gene imprinting. (wikipedia.org)
  • Aperiprosthetic osteolysis model in mouse was established by implanting 30 mg of TCP wear particles onto the surface of bilateral parietal bones following removal of the periosteum. (bvsalud.org)
  • Treatment with phenylhydrazine in mice, i.e., the iron overload liver injury model, increased plasma alanine aminotransferase and aspartate aminotransferase levels and changed histological features in mice-a response that was almost completely blocked by PN3 administration. (unboundmedicine.com)
  • Inbred strains that have a common origin, but are separated before F20 are related inbred strains, and symbols should reflect this relationship. (jax.org)

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