A rare congenital hypoplastic anemia that usually presents early in infancy. The disease is characterized by a moderate to severe macrocytic anemia, occasional neutropenia or thrombocytosis, a normocellular bone marrow with erythroid hypoplasia, and an increased risk of developing leukemia. (Curr Opin Hematol 2000 Mar;7(2):85-94)
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
Deliberate breeding of two different individuals that results in offspring that carry part of the genetic material of each parent. The parent organisms must be genetically compatible and may be from different varieties or closely related species.
Noise present in occupational, industrial, and factory situations.
An ocular disease, occurring in many forms, having as its primary characteristics an unstable or a sustained increase in the intraocular pressure which the eye cannot withstand without damage to its structure or impairment of its function. The consequences of the increased pressure may be manifested in a variety of symptoms, depending upon type and severity, such as excavation of the optic disk, hardness of the eyeball, corneal anesthesia, reduced visual acuity, seeing of colored halos around lights, disturbed dark adaptation, visual field defects, and headaches. (Dictionary of Visual Science, 4th ed)
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Leukemia induced experimentally in animals by exposure to leukemogenic agents, such as VIRUSES; RADIATION; or by TRANSPLANTATION of leukemic tissues.
C5 plays a central role in both the classical and the alternative pathway of COMPLEMENT ACTIVATION. C5 is cleaved by C5 CONVERTASE into COMPLEMENT C5A and COMPLEMENT C5B. The smaller fragment C5a is an ANAPHYLATOXIN and mediator of inflammatory process. The major fragment C5b binds to the membrane initiating the spontaneous assembly of the late complement components, C5-C9, into the MEMBRANE ATTACK COMPLEX.
An encapsulated lymphatic organ through which venous blood filters.
A fibrillar collagen found predominantly in CARTILAGE and vitreous humor. It consists of three identical alpha1(II) chains.
An experimental lymphocytic leukemia of mice.
Institutional committees established to protect the welfare of animals used in research and education. The 1971 NIH Guide for the Care and Use of Laboratory Animals introduced the policy that institutions using warm-blooded animals in projects supported by NIH grants either be accredited by a recognized professional laboratory animal accrediting body or establish its own committee to evaluate animal care; the Public Health Service adopted a policy in 1979 requiring such committees; and the 1985 amendments to the Animal Welfare Act mandate review and approval of federally funded research with animals by a formally designated Institutional Animal Care and Use Committee (IACUC).
Learning that is manifested in the ability to respond differentially to various stimuli.
The science and technology dealing with the procurement, breeding, care, health, and selection of animals used in biomedical research and testing.
The protection of animals in laboratories or other specific environments by promoting their health through better nutrition, housing, and care.
An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. The additional presence of DIACYLGLYCEROLS markedly increases its sensitivity to both calcium and phospholipids. The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters.
A curved elevation of GRAY MATTER extending the entire length of the floor of the TEMPORAL HORN of the LATERAL VENTRICLE (see also TEMPORAL LOBE). The hippocampus proper, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation.
A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.
A family of enzymes that catalyze the conversion of ATP and a protein to ADP and a phosphoprotein.
Large natural streams of FRESH WATER formed by converging tributaries and which empty into a body of water (lake or ocean).
Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing.
Time period from 1801 through 1900 of the common era.
Time period from 1701 through 1800 of the common era.
A barbiturate that is effective as a hypnotic and sedative.
Exchange of substances between the maternal blood and the fetal blood at the PLACENTA via PLACENTAL CIRCULATION. The placental barrier excludes microbial or viral transmission.
A nitrosourea compound with alkylating, carcinogenic, and mutagenic properties.
A carcinogen that is often used in experimental cancer studies.
A constitution or condition of the body which makes the tissues react in special ways to certain extrinsic stimuli and thus tends to make the individual more than usually susceptible to certain diseases.
The class of heavy chains found in IMMUNOGLOBULIN M. They have a molecular weight of approximately 72 kDa and they contain about 57 amino acid residues arranged in five domains and have more oligosaccharide branches and a higher carbohydrate content than the heavy chains of IMMUNOGLOBULIN G.
The largest of polypeptide chains comprising immunoglobulins. They contain 450 to 600 amino acid residues per chain, and have molecular weights of 51-72 kDa.
A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
A large multinuclear cell associated with the BONE RESORPTION. An odontoclast, also called cementoclast, is cytomorphologically the same as an osteoclast and is involved in CEMENTUM resorption.
Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.
A transmembrane protein belonging to the tumor necrosis factor superfamily that specifically binds RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B and OSTEOPROTEGERIN. It plays an important role in regulating OSTEOCLAST differentiation and activation.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
A meshwork-like substance found within the extracellular space and in association with the basement membrane of the cell surface. It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere.
Connective tissue cells of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.
Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.
Exclusive legal rights or privileges applied to inventions, plants, etc.

Blood thymidine level and iododeoxyuridine incorporation and reutilization in DNA in mice given long-acting thymidine pellets. (1/5198)

A long-acting thymidine pellet consisting of 190 mg of cholesterol and 60 mg of thymidine has been developed for the study of thymidine metabolism and reutilization in vivo. Implantation of such a pellet s.c. in adult mice will maintain the blood plasma concentration of thymidine at levels between 40 and 8 X 10(-6) M, which are from 36 to 7 times those of normal mice, for periods up to 48 hr. During this period, in vivo uptake and reutilization of [125I]iododeoxyuridine, a thymidine analog, into intestinal and tumor DNA were almost completely suppressed. While iododeoxyuridine reutilization is not large in normal proliferative tissue even in the absence of pellet implants, reutilization of over 30% was measured in large, rapidly growing ascites tumors. The inhibition of iododeoxyuridine incorporation by elevated thymidine blood levels is directly proportional to serum concentration. This appears to be due to a thymidine pool in rapid equilibrium with blood thymidine. This pool is at least 10 times larger than the 4-nmole pool of extracellular thymidine.  (+info)

Tissue pharmacokinetics, inhibition of DNA synthesis and tumor cell kill after high-dose methotrexate in murine tumor models. (2/5198)

In Sarcoma 180 and L1210 ascites tumor models, the initial rate of methotrexate accumulation in tumor cells in the peritoneal cavity and in small intestine (intracellularly) after s.c. doses up to 800 mg/kg, showed saturation kinetics. These results and the fact that initial uptake in these tissues within this dosage range was inhibited to the expected relative extent by the simultaneous administration of leucovorin suggest that carrier mediation and not passive diffusion is the major route of drug entry at these extremely high doses. Maximum accumulation of intracellular drug occurred within 2 hr and reached much higher levels in small intestine than in tumor cells at the higher dosages. At a 3-mg/kg dose of methotrexate s.c., intracellular exchangeable drug levels persisted more than four times longer in L1210 cells than in small intestine, but differences in persistence (L1210 cell versus gut) diminished markedly with increasing dosage. At 96 mg/kg, the difference in persistence was less than 2-fold. In small intestine and L1210 cells, theduration of inhibition of DNA synthesis at different dosages correlated with the extent to which exchangeable drug was retained. Toxic deaths occurred when inhibition in small intestine lasted longer than 25 to 30 hr. Recovery of synthesis in small intestine and L1210 cells occurred synchronously and only below dosages of 400 mg/kg. Within 24 hr after dosages of greater than 24 mg/kg, the rate of tumor cell loss increased to a point characterized by a single exponential (t1/2=8.5 hr). The total cell loss, but not the rate of cell loss, was dose dependent.  (+info)

Lung weight parallels disease severity in experimental coccidioidomycosis. (3/5198)

Evidence provided by histopathological study of lesions is a valuable adjunct for evaluating chemotherapeutic efficacy in experimental animal models, In addition, this should be correlated with a measure of disease severity in the same animal. The latter could be obtained by homogenization of infected organs and quantitative enumeration of viable cells of the etiological agent, but this would preclude histopathological studies in the same animal. Progression of disease in pulmonary infection is associated with replacement of air space by fluid, cells, and cellular debris. Therefore, an increase in lung weight should reflect severity of disease. Results with the murine model of coccidioidomycosis demonstrate that increasing lung weight parallels the increasing census of fungus cells in the lungs of both treated and nontreated infected mice. This was supported with evidence obtained from microscopic studies of lesions indicating that specific chemotherapy limited spread of the infection and inhibited multiplication of the fungus in the lung. Therefore, lung weight can be used as a measure of disease severity in the murine model of coccidioidomycosis.  (+info)

Prevention of collagen-induced arthritis by gene delivery of soluble p75 tumour necrosis factor receptor. (4/5198)

Collagen type II-induced arthritis (CIA) in DBA/1 mice can be passively transferred to SCID mice with spleen B- and T-lymphocytes. In the present study, we show that infection ex vivo of splenocytes from arthritic DBA/1 mice with a retroviral vector, containing cDNA for the soluble form of human p75 receptor of tumour necrosis factor (TNF-R) before transfer, prevents the development of arthritis, bone erosion and joint inflammation in the SCID recipients. Assessment of IgG subclass levels and studies of synovial histology suggest that down-regulating the effector functions of T helper-type 1 (Th1) cells may, at least in part, explain the inhibition of arthritis in the SCID recipients. In contrast, the transfer of splenocytes infected with mouse TNF-alpha gene construct resulted in exacerbated arthritis and enhancement of IgG2a antibody levels. Intriguingly, infection of splenocytes from arthritic DBA/1 mice with a construct for mouse IL-10 had no modulating effect on the transfer of arthritis. The data suggest that manipulation of the immune system with cytokines, or cytokine inhibitors using gene transfer protocols can be an effective approach to ameliorate arthritis.  (+info)

Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes. (5/5198)

Dysfunction of the pancreatic beta cell is an important defect in the pathogenesis of type 2 diabetes, although its exact relationship to the insulin resistance is unclear. To determine whether insulin signaling has a functional role in the beta cell we have used the Cre-loxP system to specifically inactivate the insulin receptor gene in the beta cells. The resultant mice exhibit a selective loss of insulin secretion in response to glucose and a progressive impairment of glucose tolerance. These data indicate an important functional role for the insulin receptor in glucose sensing by the pancreatic beta cell and suggest that defects in insulin signaling at the level of the beta cell may contribute to the observed alterations in insulin secretion in type 2 diabetes.  (+info)

The cerebral metabolic consequences of nitric oxide synthase deficiency: glucose utilization in endothelial and neuronal nitric oxide synthase null mice. (6/5198)

Nitric oxide has multiple physiologic roles in the CNS. Inhibiting nitric oxide synthesis might therefore alter functional activity within the brain. We used [14C]-2-deoxyglucose in vivo autoradiography to measure local CMRglc in "knockout" mice lacking the genes for either the endothelial (eNOS) or neuronal (nNOS) isoforms of nitric oxide synthase, and in the progenitor strains (SV129, C57B1/6). Glucose utilization levels did not significantly differ between nNOS and eNOS knockout mice and C57B1/6 mice in any of the 48 brain regions examined, but were relatively lower in some subcortical regions in SV129 mice.  (+info)

T cell subsets in experimental lupus nephritis: modulation by bacterial superantigen. (7/5198)

Chronic graft-vs-host disease (GvH), induced by injection of DBA/2 lymphocytes into (C57BL/6 x DBA/2)F1 hybrids, is a murine model for lupus nephritis, associated with a Th2-dependent polyclonal B cell activation. The development of glomerulosclerosis in this model is preceded by a glomerular influx of LFA-1+ T cells. We investigated whether exposure to bacterial superantigen would modulate the course of this autoimmune syndrome. Injection of the bacterial superantigen staphylococcal enterotoxin B (SEB) in mice has been shown to induce the activation of TcRVbeta8+ T cells. Within 2 weeks after GvH induction, mice were injected twice with 20 microg of SEB and the following parameters were examined: cytokine and Ig profile, proteinuria and renal pathology. The second SEB injection induced in GvH mice an increased release of both interferon-gamma (IFN-gamma) and interleukin-10 (IL-10) as compared with control F1 mice. No differences were observed in IL-2 production. SEB-treated GvH mice demonstrated a delayed onset of proteinuria. Histological analysis of the kidney showed that SEB-challenged GvH mice displayed significantly more interstitial inflammation and mesangial proliferation together with more IgG2a deposits in glomeruli than non-injected GvH mice. From these results, we conclude that GvH mice are more responsive to SEB in terms of cytokine production and that bacterial infection can modulate the course of this renal disease from a membranous to a more proliferative type of nephropathy.  (+info)

Development and function of autospecific dual TCR+ T lymphocytes. (8/5198)

Recent studies have challenged the long held concept that each T lymphocyte expresses on its surface only a single, unique alphabetaTCR. Dual TCR+ T cells have been recognized, however, their origin and potential to escape screening for self-reactivity remain obscure. We now report the thymic generation of dual alphabetaTCR+ T cells in the H-2Db/H-Y-specific TCR transgenic (Tg) mouse. Dual TCR+ thymocytes were positively selected less efficiently than single TCR+ thymocytes, although a subset attained maturity. Importantly, when TCR Tg mice were bred onto a negatively selecting background, auto-specific cells survived central deletion and matured as CD4+ dual TCR+ cells. These cells were autoreactive when CD8 expression was restored. The existence of autospecific, dual TCR+ T cells may have implications for the maintenance of self tolerance.  (+info)

Nine additional BXD recombinant inbred (RI) strains have been developed from the F2 cross of C57BL/6J and DBA/2J mouse strains. A tenth line stopped breeding in the F12 generation. F20 generation breeding pairs from the nine surviving strains and an F12 pair from the extinct line were genotyped at 319 genetic markers (primarily microsatellites) spanning most of the genome. Where typing data were lacking, the established set of 26 BXD strains also were genotyped at these same loci. The availability of these additional nine strains enhances the value of the BXD RI set for analysis of complex phenotypic traits. The proportion of loci still segregating at the F20 generation was found to closely approximate expectation, suggesting that selection favoring the retention of heterozygosity is not a strong factor. However, the number of crossovers between adjacent markers was frequently less than predicted from consensus map distances. A significant deficiency of recombinants was observed on Chrs 3,
Johansson AC, Sundler M, Kjellen P, Johannesson M, Cook A, Lindqvist AK, et al. Genetic control of collagen-induced arthritis in a cross with NOD and C57BL/10 mice is dependent on gene regions encoding complement factor 5 and FcγRIIb and is not associated with loci controlling diabetes. Eur J Immunol 2001; 31: 1847-56 ...
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sub filter_duplicates { my $self = shift; my $overlap = $self-,param(overlap); my $chunk_size = $self-,param(chunk_size); my $window_size = $self-,param(window_size); $self-,param(overlap_count, 0); $self-,param(identical_count, 0); $self-,param(gab_count, 0); $self-,param(truncate_count, 0); $self-,param(not_truncate_count, 0); $self-,param(delete_hash, {}); #all the genomic_align_blocks that need to be deleted my $mlss = $self-,compara_dba-,get_MethodLinkSpeciesSetAdaptor-,fetch_by_dbID($self-,param(method_link_species_set_id)); # my ($gdb1, $gdb2) = @{$mlss-,species_set}; # if($gdb1-,dbID , $gdb2-,dbID) { # my $tmp = $gdb1; $gdb1=$gdb2; $gdb2=$tmp; # } my $GAB_DBA = $self-,compara_dba-,get_GenomicAlignBlockAdaptor; # create a list of dnafrag here in case we want to make this runnable working with an input_id # containing a list of dnafrag_ids my $dnafrag_list = [$self-,compara_dba-,get_DnaFragAdaptor-,fetch_by_dbID($self-,param(dnafrag_id))]; foreach my $dnafrag ...
chr12:113416669-113417101, - strand. Annotation of mouse strain DBA/2J genome assembly provided by GENCODE consortium. Distributed via Ensembl Release 92. Gene type: gene segment; Gene Name: Ighv1-67 ...
chr5:39361776-39504893, + strand. Annotation of mouse strain DBA/2J genome assembly provided by GENCODE consortium. Distributed via Ensembl Release 92. Gene type: protein coding gene; Gene Name: Gm16223 ...
Good point from Anonymous - the DBA have had a handful of in-house design teams as members for a number of years - but these are being fazed out.. The news announced at the AGM is that it is the whole organisations which are joining the DBA. Rather than in-house design teams, it is the design buying and design management functions that are leading the relationship. We are forging relationships were they matter most to both our existing agency membership and on the new client side.. And as for the tough trading conditions, yes they are tough, but we were also pleased to report at the AGM that membership (not including the new client side businesses) is at the highest level that it has ever been - and double what it was 10 years ago.. It is good to see that more and more design agencies are benefiting from belonging to their trade association - which many see as more important in these tough times.. ...
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So that we can help you further, it would be great if you could please provide us with some more information. Due to our relocation and setting up of the new property at Euroa Horse Park, we may not be able to respond as quickly as wed like, so please feel free to give Ness a ring on 0417 363 710 in the meantime ...
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The Rho family GTPase Rac1 regulates cytoskeletal rearrangements crucial for the recruitment, extravasation and activation of leukocytes at sites of inflammation. Rac1 signaling also promotes the activation and survival of lymphocytes and osteoclasts. Therefore, we assessed the ability of a cell-permeable Rac1 carboxy-terminal inhibitory peptide to modulate disease in mice with collagen-induced arthritis (CIA). CIA was induced in DBA/1 mice, and in either early or chronic disease, mice were treated three times per week by intraperitoneal injection with control peptide or Rac1 inhibitory peptide. Effects on disease progression were assessed by measurement of paw swelling. Inflammation and joint destruction were examined by histology and radiology. Serum levels of anti-collagen type II antibodies were measured by enzyme-linked immunosorbent assay. T-cell phenotypes and activation were assessed by fluorescence-activated cell sorting analysis. Results were analyzed using Mann-Whitney U and unpaired Student
The effects of oxiracetam on hippocampally-mediated learning performance and hippocampal protein kinase C (PKC) were examined in C57BL/6Ibg (C57) and DBA/2Ibg (DBA) mice. C57 and DBA mice were subjected to daily injections of oxiracetam (50 mg/kg i.p.) or vehicle (0.9% saline) for a total of 9 days. …
The use of regulatory or immature dendritic cells (DCs) as tools for modulating experimental rheumatoid arthritis is very recent. TNF-stimulated DCs have been shown to restore tolerance in experimental autoimmune encephalomyelitis and collagen-induced arthritis (CIA).. Objective: We investigated the capacity of short-term lipopolysaccharide (LPS)-stimulated DCs pulsed with type-II collagen (CII) to induce tolerance against established CIA.. Methods: Bone marrow-derived DCs were generated in the presence of GM-CSF. After CIA induction, mice were injected at day 35 with a single dose of 4- or 24-hour LPS-stimulated DCs that had been loaded with CII (CII/DCs, 4hLPS/CII/DCs or 24hLPS/CII/DCs). Arthritis progression was monitored by clinical and histologic evaluations.. Results Flow cytometry of 4hLPS/CII/DCs showed intermediate CD40 and CD86 expression, lower than that of 24hLPS/CII/DCs (fully mature) and higher than that of CII/DCs (immature). A functional assay showed that 4hLPS/CII/DCs display ...
The DNA binding activity of AP-1 and NF-kappaB are markedly increased in both CIA and RA. In CIA, activation of AP-1 and NF-kappaB precede both clinical arthritis and metalloproteinase gene expression. NF-kappaB expression correlated better than AP-1 with metalloproteinase expression.
Methods Arthritis was induced in male C57BL/6 wild-type (WT), LXRα−/−, LXRβ−/− and LXRα/β double KO mice by injection with type II collagen and treated with 30 mg/kg of the LXR agonist GW3965 or vehicle control. The mice were monitored for articular inflammation and cartilage degradation by scoring for clinical signs of arthritis and by histological examination of the joints.. ...
Fingerprint Dive into the research topics of Transforming growth factor β-transduced mesenchymal stem cells ameliorate experimental autoimmune arthritis through reciprocal regulation of Treg/Th17 cells and osteoclastogenesis. Together they form a unique fingerprint. ...
(a)-(c) Typical histological appearance of CIA mouse paws: (a) severe inflammatory cellular infiltration-synovitis and pannus formation; (b) bone and cartil
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TY - JOUR. T1 - Effective treatment of established murine collagen-induced arthritis by systemic administration of dendritic cells genetically modified to express IL-4. AU - Kim, S. H.. AU - Kim, S.. AU - Evans, C. H.. AU - Ghivizzani, S. C.. AU - Oligino, T.. AU - Robbins, P. D.. N1 - Copyright: Copyright 2017 Elsevier B.V., All rights reserved.. PY - 2001/3/1. Y1 - 2001/3/1. N2 - Dendritic cells (DC) are APCs that are able to stimulate or inhibit immune responses, depending on levels of expression of MHC class I and II costimulatory molecules and cytokines. Our previous studies have suggested that the observed contralateral effect, where injection of a vector carrying certain immunomodulatory genes into one joint resulted in inhibition of arthritis in untreated joints, is mediated by in vivo modification of DC. Therefore, we have examined the ability of genetically modified DC to suppress established murine collagen-induced arthritis (CIA) after i.v. delivery. IL-4 has been shown to partially ...
There is considerable evidence implicating tumor necrosis factor alpha (TNF-alpha) in the pathogenesis of rheumatoid arthritis. This evidence is based not only on the universal presence of TNF-alpha in arthritic joints accompanied by the upregulation of TNF-alpha receptors but also on the effects of neutralizing TNF-alpha in joint cell cultures. Thus, neutralization of TNF-alpha in vitro results in inhibition of the production of interleukin 1, which like TNF-alpha, is believed to contribute to joint inflammation and erosion. To determine the validity of this concept in vivo, the effect of administering TNF-neutralizing antibodies to mice with collagen-induced arthritis has been studied. This disease model was chosen because of its many immunological and pathological similarities to human rheumatoid arthritis. TN3-19.12, a hamster IgG1 monoclonal antibody to murine TNF-alpha/beta, was injected i.p. into mice either before the onset of arthritis or after the establishment of clinical disease. Anti-TNF
Abstract: To evaluate the effect of methotrexate on collagen-induced arthritis, micro-computed tomography (micro-CT) and histopathological analyses were used in male Wistar rats. Rats were divided randomly into three groups. Group 1 was treated with 0.9% saline, and groups 2 and 3 were boosted with type Ⅱ collagen. From day 21 to 42, groups 1 and 2 were orally treated with 0.9% saline and group 3 was orally treated with 1.5 mg/kg methotrexate. All rats were sacrificed at day 42 after the first collagen treatment. Micro-CT analyses showed bony parameters, such as bone volume and trabecular number, were decreased in group 2 compared to group 1, and these parameters were recovered in group 3. Histopathological examination and pathological parameter scoring showed that the knee joints of rats in group 2 had severe joint destruction, showing cartilage and bone erosion, enlarged cavities with inflammatory cell infiltration and activation of synovial fibroblasts. By contrast, these changes were ...
Les Produits de Chondrex Modèles animaux Anticorps Tests danticorps Recherche sur les bactéries Recherche contre le cancer Collagène Collagénase HMGB1 Dosages de protéines Coloration des tissus Tampons dimmunoanalyse Métabolisme cellulaire Les MSDS ou fiches de données de sécurités Protocoles Gentaur Assay kits en collaboration Animal Model Protocols Arthritis Scoring System Collagen Antibody-Induced Arthritis - Mouse (cat# 53010, 53040, 53100) Collagen-Induced Arthritis - Mouse Collagen-Induced Arthritis - Mouse (Visual Guide) Collagen-Induced Arthritis - Rat Adjuvant-Induced Arthritis - […]. ...
Mutational activation of the K-ras oncogene often occurs in human and mouse lung adenocarcinomas. Since K-ras p21 functions in trans-membrane signaling, we have investigated whether the amount of this protein in lung cell membranes is a variable that could influence lung tumorigenesis, either due to genetic differences or in response to tumor promoters. The six mouse strains assessed showed little difference in the total lung K-ras p21 after immunoprecipitation and immunoblotting. However, amount of ras p21 in the membrane fraction showed significant differences, with C57BL/6 and BALB/c having 3-5-fold more than NIH Swiss, AKR and DBA mice. Interestingly, a congenic AKR strain having the Ahr(b-1) Ah receptor allele from C57BL/6 mice (designated AKR.B6Ah) had high lung membrane K-ras p21 similar to that of C57BL/6. To test for possible changes related to lung tumor promotion, mice were treated with a promotional dose of TCDD (5 nmol/kg). After 48 h C57BL/6 lungs showed an increase in p21 in both ...
Introduction: The Vbeta12-transgenic mouse was previously generated to investigate the role of antigen-specific T cells in collagen-induced arthritis (CIA), an animal model for rheumatoid arthritis. This mouse expresses a transgenic collagen type II (CII)-specific T-cell receptor (TCR) beta-chain and consequently displays an increased immunity to CII and increased susceptibility to CIA. However, while the transgenic Vbeta12 chain recombines with endogenous alpha-chains, the frequency and distribution of CII-specific T cells in the Vbeta12-transgenic mouse has not been determined. The aim of the present report was to establish a system enabling identification of CII-specific T cells in the Vbeta12-transgenic mouse in order to determine to what extent the transgenic expression of the CII-specific beta-chain would skew the response towards the immunodominant galactosylated T-cell epitope and to use this system to monitor these cells throughout development of CIA. Methods: We have generated and ...
Mediators of Inflammation is a peer-reviewed, Open Access journal that publishes original research and review articles on all types of inflammatory mediators, including cytokines, histamine, bradykinin, prostaglandins, leukotrienes, PAF, biological response modifiers and the family of cell adhesion-promoting molecules.
TY - JOUR. T1 - Early pro-inflammatory cytokine elevations in the DBA/2J mouse model of glaucoma. AU - Wilson, Gina N.. AU - Inman, Denise M.. AU - Denger-Crish, Christine M.. AU - Smith, Matthew A.. AU - Crish, Samuel D.. PY - 2015/9/17. Y1 - 2015/9/17. N2 - Background: Neuroinflammation-astrogliosis, microglial activation, and changes in cytokine signaling-is a prominent feature of neurodegenerative disorders. Glaucoma is a group of chronic neurodegenerative conditions that make up the leading cause of irreversible blindness worldwide. Neuroinflammation has been postulated to play a significant role in the pathogenesis and progression of glaucomatous neurodegeneration. Though much is known regarding inflammation in the eye in glaucoma, little is known about cytokine activity outside of the retina where pathologies develop early. Methods: We traced the primary visual projection from the eye to the superior colliculus (SC) in DBA/2J and DBA/2J.Gpnmb + (control) mice using the anterograde tracer ...
Decreased production of anti-CII antibodies in mice treated with anti-IL-23p19.At day 35, at the end of the experiment as shown in Figure 2A, serum was collecte
Bovine collagen is derived from beef cattle - its a naturally occurring protein found in the cartilage, joints, and bones of cattle. Bovine collagen is rich in type I and III collagen. This type of collagen benefits skin, hair, nails, muscles, tendons, bones, eyes, and blood vessels. Collagen peptide is an off white t
Y-320 is an orally active immunomodulator, and inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC50 of 20 to 60 nM. Y-320 also inhibits the production of IFN-γ and TNF-α by mouse CD4 T cells stimulated with IL-15, CXCL12, and anti-CD3 mAb. Y-320 (0.3-3 mg/kg p.o.) ameliorates collagen-induced arthritis (CIA) in Mice with a reduction of IL-17 mRNA in arthritic joints, and also shows therapeutic effects on CIA in cynomolgus monkeys. Moreover, Y-320 shows a synergistic effect in combination with anti-TNF-α mAb on chronic-progressing CIA in mice. Selleck Chemicals Y-320, IL-17 Inhibitor. 26 Sep 2014. Ushio H, et al. (2013). A new phenylpyrazoleanilide, y-320, inhibits interleukin 17 production and ameliorates collagen-induced arthritis in mice and cynomolgus monkeys. Pharmaceuticals (Basel). 7 (1): 1-17. doi:10.3390/ph7010001. PMC 3915191 . PMID 24366113 ...
Therapeutic Treatment of Arthritic Mice with 15-Deoxy Δ12,14-Prostaglandin J2 15d-PGJ2 Ameliorates Disease through the Suppression of Th17 Cells and the Induction of CD4 CD25−FOXP3 Cells. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
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As many of you know, the Daniella Maria Arturi Foundation (DMAF) has worked with the United States Department of Health and Human Services Centers for Disease Control and Prevention (CDC) for many years on efforts to improve DBA outreach, education and surveillance initiatives. Over the course of this effort CDC together with nurses and doctors from DBA resource centers and DBA patient groups have produced a series of helpful DBA fact sheets that are helping increase awareness of DBA and the steps to take to improve the quality of life for people living with DBA.. DMAF is excited to announce that CDC has continued to expand the resources available to the DBA community by developing a Spanish version of the DBA website, available at by clicking here!. We are very proud of the work everyone in the DBA community has done over the years to make materials available for families dealing with this rare condition. The DBA Care notebook and the accompanying factsheets are a welcomed source of knowledge, ...
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Report says interrogations were more brutal than CIA had said and it misled Congress and White House about its activities; agency disputes reports conclusions
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... of the Discriminative Stimulus Effects of the Neuroactive Steroid Pregnanolone in DBA/2J and C57BL/6J Inbred Mice". Journal of ...
The mouse-derived erythroleukemia cell line F4N (MEL) is an aneuploid cell line, comes from mouse inbred strain DBA/2. It was ... "Induction of endogenous and of spleen focus-forming viruses during dimethylsulfoxide-induced differentiation of mouse ...
"Differential effect of inbred mouse strain (C57BL/6, DBA/2, 129T2) on insulin secretory function in response to a high fat diet ... For example, mice were put on a high-fat diet, but given either tap water, green tea, or Goishi tea to drink. The mice who ... West, D. B.; Boozer, C. N.; Moody, D. L.; Atkinson, R. L. (1992-06-01). "Dietary obesity in nine inbred mouse strains". The ... Scientists used mice to study the effect of lymphotoxins on metabolism. Mice without lymphotoxin alpha, lymphotoxin beta, or a ...
"Genetic sensitivity to hot-plate nociception in DBA/2J and C57BL/6J inbred mouse strains: possible sex-specific mediation by δ2 ... female mice are more sensitive to itch than male mice; pain reduces sexual desire in male but not female mice; sex differences ... They showed that mice display more pain behavior if they are tested in close proximity to other mice also in pain, but only if ... In 1999, they showed that different inbred strains of mice displayed very different pain sensitivity. Chief among these ...
... his own DBA strain was probably derived from her partially inbred silver fawn mice. Karin Knorr Cetina wrote in 2009 that at ... She bred Japanese waltzing mice as well as fancy mice. The mice had straw bedding and lived in wooden boxes. They were fed a ... Abbie E. C. Lathrop (1868 - 1918) was a rodent fancier who bred fancy mice and inbred strains for animal models, particularly ... Lathrop started out with a pair of waltzing mice she obtained in Granby and her farm grew to hold over 11,000 mice at one point ...
C57BL/6 mice are highly resistant to the virus, while DBA/2J mice are sensitive. C57BL/6 mice showed slight loss of body weight ... Parker JC, Whiteman MD, Richter CB (January 1978). "Susceptibility of inbred and outbred mouse strains to Sendai virus and ... It was suggested that the mice used to passage the virus were infected with the mouse virus. Thus, mouse virus was later ... The virus can be detected in mouse colonies worldwide, generally in suckling to young adult mice. A study in France reported ...
... mice, inbred cba MeSH B01.050.157.520.445 - mice, inbred cftr MeSH B01.050.157.520.460 - mice, inbred dba MeSH B01.050.157.520. ... mice, inbred cba MeSH B01.050.199.520.520.445 - mice, inbred cftr MeSH B01.050.199.520.520.460 - mice, inbred dba MeSH B01.050. ... mice, inbred a MeSH B01.050.157.520.318 - mice, inbred akr MeSH B01.050.157.520.338 - mice, inbred balb c MeSH B01.050.157.520. ... mice, inbred a MeSH B01.050.199.520.520.318 - mice, inbred akr MeSH B01.050.199.520.520.338 - mice, inbred balb c MeSH B01.050. ...
... inbred mouse strain and the systematic generation of other inbred strains. The mouse has since been used extensively as a model ... on mouse genetics in the laboratory of William Ernest Castle in collaboration with Abbie Lathrop led to generation of the DBA ... Use mouse biobanks or lose them Knock Out Mouse Project - KOMP Mouse Biology Program Mutant Mouse Resource & Research Centers, ... "Dirty" mice are possibly better suitable for mimicking human pathologies. In addition, inbred mouse strains are used in the ...
In 1921 he inbred the mouse strain C57BL/6 or "black 6", which is the most popular laboratory mouse to date. His most important ... Little developed the "DBA (Dilute, Brown and non-Agouti)" strain of mice while at Harvard. For his research, he received ... CS1 maint: discouraged parameter (link) C. C. Little, Cancer and Inbred Mice by James F. Crow, "Genetics", Vol. 161, 1357-1361 ... The lab was quickly rebuilt and most mouse strains were recovered from other labs around the world. By 1950 the lab was ...
... now widely distributed as the two major sub-strains DBA/1 and DBA/2, which were separated in 1929-1930. DBA mice were nearly ... Soon after World War I, inbreeding in mice was started on a much larger scale by Dr L. C. Strong, leading in particular to the ... A/J C3H C57BL/6 CBA DBA/2 BALB/c G.M. Rommel first started conducting inbreeding experiments on guinea pigs in 1906. Strain 2 ... A genealogical chart of mouse inbred strains can be found here on the Jackson Laboratory website and is currently being ...
The first inbred strain, DBA (dilute brown agouti), was developed in 1909. Among the earliest references to the use of inbred ... MMHCdb contains genetic and genomic information about inbred mouse strains, genetically engineered mouse models (GEMMs) and ... Inbred mouse strains are the result of at least 20 generations of successive brother/sister matings which lead to a population ... Inbred strains of mice allow researchers to investigate the role that genetics plays in cancer susceptibility and treatment ...
In 1909, Clarence C. Little developed the first inbred strain, the DBA (Dilute, brown non-Agouti) mouse. In 1915, N.M Haldane ... Mice have relatively short gestation periods. Mice take a brief time to reach sexual maturity. Mice have large litter sizes. ... The number of mouse genes without a corresponding human homologue is less than 1%. 90% of the human and mouse genomes are ... Various mouse mammary carcinoma cell lines, like 4T1 and TS/A, are metastatic in syngeneic immunocompetent mice and can be used ...
... learning in three inbred strains of mice". Brain Research. 785 (2): 236-244. doi:10.1016/S0006-8993(97)01417-0. PMID 9518631. ... "Inheritance of discrimination learning ability and retention in BA and DBA mice". Behavior Genetics. 11 (2): 173-177. doi: ...
These inbred mice have recombinant genomes that are developed to ensure every strain is equally related, this eradicates ... and cytochrome p450 induction after maternal TCDD exposure in DBA/2J mice with low-responsive aryl hydrocarbon receptors". ... While DO mice have the identical alleles to the CC mice population. There are two major differences in these mice; 1) every ... The CC population consists of 83 inbred mouse strains that over many generations in labs came from the 8 founder strains. ...
... stress has been associated with an enhanced probability of survival during influenza infection in this strain of mouse. Previo ... infection was used to evaluate the effects of restraint stress on pathogenesis and survival in the DBA/2 inbred strain of mice ... infection was used to evaluate the effects of restraint stress on pathogenesis and survival in the DBA/2 inbred strain of mice ... changes attributable to the sympathetic nervous system during experimental influenza viral infection in DBA/2 inbred mouse ...
Subjects. Twelve DBA/2J male mice, 13 DBA/2J female mice, 12 C57BL/6J male mice, and 12 C57BL/6J female mice were obtained from ... Pregnanolone. DBA/2J male mice (n = 12), DBA/2J female mice (n = 13), and C57BL/6J female mice (n = 12) acquired the ... for the male DBA/2J mice, 4 mg/kg (CI 3-5) for the female C57BL/6J mice, and 4 mg/kg (CI 1-7) for the female DBA/2J mice. There ... The ED50 values were 68 mg/kg (CI 58-77) for the male DBA/2J mice and 62 mg/kg (CI 39-84) for the female DBA/2J mice, which ...
DBA/2, and C57BL/6 mice. Ethanol increased locomotor activity in DBA and BALB mice, but not in C57BL mice. Naltrexone, at a ... METHODS: Arthritis was induced in DBA/1J mice by subcutaneous immunization with bovine type II collagen on days 0 and 21. CHE ... Antagonism of the behavioral effects of ethanol by naltrexone in BALB/c, C57BL/6, and DBA/2 mice. ... K5-mTert transgenic mice overexpress telomerase in a wide spectrum of tissues. These mice have a higher incidence of both ...
Xu, Y, Demarest, K, Hitzemann, R & Sikela, JM 2002, Gene coding variant in Cas1 between the C57bl/6J and DBA/2J inbred mouse ... N2 - Background: Among some (e.g., DBA/2J or D2) but not all (C57BL/6J or B6) inbred strains of mice, ethanol has a marked ... AB - Background: Among some (e.g., DBA/2J or D2) but not all (C57BL/6J or B6) inbred strains of mice, ethanol has a marked ... Background: Among some (e.g., DBA/2J or D2) but not all (C57BL/6J or B6) inbred strains of mice, ethanol has a marked ...
Strain-A offspring are nearly all affected; DBA-mice, about 75% affected; and C57BL-mice, about 20% affected. The strain-A ... CONGENITAL MALFORMATIONS INDUCED BY RIBOFLAVIN DEFICIENCY IN STRAINS OF INBRED MICE Message Subject (Your Name) has sent you a ... Acute maternal deprivation of riboflavin at the end of the middle-third of pregnancy of inbred mice has thus been shown to ... First, it does not explain why cortisone regularly induces cleft palate in DBA-and C57BL-mice, which never have cleft lip and ...
Standardized behavioral assays that measure the preference of mice for initiating social interactions with novel conspecifics ... Five inbred strains of mice were tested, C57BL/6J, DBA/2J, FVB/NJ, A/J and B6129PF2/J hybrids. Four strains showed significant ... Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice ... In a secondary test, preference for social novelty was quantitated by presenting the test mouse with a choice between the first ...
Here we describe differences in the cortical area map of two commonly used inbred strains of laboratory mice, C57BL/6J and DBA/ ... Inbred strains of laboratory mice can be exploited to study cortical area map formation if there are significant phenotypic ... C57BL/6J and DBA/2J have markedly different cortical area maps, suggesting that inbred strains harbor enough phenotypic ... The sample of C57BL/6J and DBA/2J mice can be discriminated with 90% accuracy on the basis of these three size dimensions. ...
Genetic variation in hippocampal microRNA expression differences in C57BL/6 J X DBA/2 J (BXD) recombinant inbred mouse strains ... Genetic variation in hippocampal microRNA expression differences in C57BL/6 J X DBA/2 J (BXD) recombinant inbred mouse strains ... We surveyed variation in miRNA abundance in the hippocampus of mouse inbred strains, allowing us to take a genetic approach to ... The BXD recombinant inbred panel is a very well characterized genetic reference panel which allows quantitative trait locus ( ...
N2 - The inbred mouse strains, DBA/2J (D2) and C57BL/6J (B6), display differential sensitivity to acute, thermal nociception as ... AB - The inbred mouse strains, DBA/2J (D2) and C57BL/6J (B6), display differential sensitivity to acute, thermal nociception as ... The inbred mouse strains, DBA/2J (D2) and C57BL/6J (B6), display differential sensitivity to acute, thermal nociception as ... abstract = "The inbred mouse strains, DBA/2J (D2) and C57BL/6J (B6), display differential sensitivity to acute, thermal ...
Comparing cortical phenotypes between normally varying inbred mice or between genetically modified mice can identify genetic ... and neocortex that collectively discriminated C57BL/6J and DBA/2J inbred strain identity. Here we use a novel application of ... characterize the cortical area maps of these common inbred, isogenic strains. C57BL/6J and DBA/2J have markedly different ... We compared the variation in shape between C57BL/6J and DBA/2J relative to that within each strain using a permutation test of ...
... and DBA/2J (D2) mice. B6 mice were more sensitive than D2 mice to a subset of bitter stimuli, including quinine hydrochloride ( ... D2 mice were more sensitive than B6 mice to the bitter stimulus raffinose undecaacetate (RUA). These strains did not differ in ... With a few exceptions, previous characterizations of behavioral taste sensitivity in inbred mouse strains have generally ... The results of these studies point to the utility of these common mouse strains and their associated resources for ...
Inbred Strain. Place Order. Typically mice are recovered in 10-14 weeks. Contact Customer Service to place an order or for more ... When using the DBA/2HaSmnJ mouse strain in a publication, please include JAX stock #000973 in your Materials and Methods ... Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available ... Therefore, we cannot guarantee a strains phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of ...
DBA/2 Mouse Ideal For. Safety and efficacy testing, immunology, audiogenic seizures ...
Inbred Strains of Mice: C57L. C57L Inbr: F 130 +. Grey (colour very similar to DBA). Genet: a, b, ln. Origin: Murray 1933 from ... West D. B., Boozer C. N., Moody D. L., and Atkinson R. L. (1992) Dietary obesity in nine inbred mouse strains. Am. J. Physiol. ... Hutton J. J. and Gross S. R. (1970) Chemical induction of hepatic porphyria in inbred strains of mice. Arch. Biochem. Biophys. ... Taylor B. A. (1972) Genetic relationship between inbred strains of mice. J. Hered. 63, 83-86. \par. Tennant J. R. (1965) ...
Mice. Mice, Inbred DBA. Plethysmography / methods. Pulmonary Ventilation. Respiration / drug effects*. Resuscitation*. Tidal ... or NaCl in 9-day-old DBA/1lacJ mice. Using flow plethysmography, we show that mice given IL-1beta exhibited a decreased tidal ... Mice given IL-1beta exhibited fewer gasps and were unable to sustain gasping efforts for as long as control animals. ... These findings indicate that infection may adversely affect central respiratory control in newborn mice via interleukin-1beta. ...
Mice. Mice, Inbred C57BL. Mice, Inbred DBA. Mice, Knockout. Osteoclasts / cytology, drug effects, physiology*. Receptors, IgG ... of SPA in the early stages of disease substantially alleviated the clinical and histologic erosive features of CIA in mice. ...
2004) Social approach-avoidance behavior of inbred mouse strains towards DBA/2 mice. Brain Res 1002:151-157. ... All mice tested were 12 weeks of age. As compared to Pten+/+ mice, Pten+/− mice have significant deficits in startle inhibition ... We generated mice for this study from two crosses: Pten+/−; Slc6a4+/+ × Pten+/+; Slc6a4+/+ mice to yield Pten+/+; Slc6a4+/+ (" ... Time spent with a social stimulus mouse in chamber 1 is significantly decreased in Pten+/−; Slc6a4+/− mice as compared to Pten ...
C3H, C57Bl/6, Balb/c, and DBA/2 are inbred strains of mice; CD-1 is an outbred strain of mouse; while B6D2F1 (BDF1) and B6C3F1 ... whether they were inbred, outbred or hybrid mice. B6D2F1 and DBA/2 produced the greatest level of hematopoietic cell production ... A mutant strain of mice can be used in which the CSF-1 gene (B6C3Fe-a/a-op/op mouse strain) or the gene for its receptor or ... Mouse collagen IV (Sigma) was used at a range of concentrations from 0-15 μg/cm2, whereas mouse fibronectin (Sigma) was used at ...
The DBA/2J mouse is not only the oldest inbred strain, but also one of the most widely used strains. DBA/2J exhibits many ... In addition, DBA/2J is one parent of the large BXD family of recombinant inbred strains [1]. The genome of the other parent of ... A new set of BXD recombinant inbred lines from advanced intercross populations in mice. BMC genetics 2004, 5: 7. 10.1186/1471- ... The DBA/2J genome is also an essential prerequisite to unbiased alignment of RNA-seq and ChIP-seq data generated using BXD ...
Social approach-avoidance behavior of inbred mouse strains towards DBA/2 mice. Brain Research 1002: 151-157, 2004.. Brodkin E.S ... BALB/cJ inbred mouse strains. Biological Psychiatry 59: 415-423, 2006.. Gillihan S.J., Farah M.J., Sankoorikal G.M.V., Breland ... Low sociability is associated with reduced size of the corpus callosum in the BALB/cJ inbred mouse strain. Brain Research 1230 ... Sankoorikal G.M.V., Kaercher K.A., Boon C.J., Lee J.K., Brodkin E.S. : A mouse model system for genetic analysis of sociability ...
Mice, Inbred DBA. *Neoplasms, Experimental (immunology, pathology) *T-Lymphocyte Subsets (immunology) *T-Lymphocytes, Cytotoxic ... Vaccination of mice with P815 tumor lysate-pulsed CD4+ 8+ TID815 or TID198 and CD4+ 8- TID198 induced IFN-gamma-secreting Th1 ... Transfer of CD4+ Tr1 cells obtained from CD4- 8- TID815-immunized wild-type, but not IL-10(-/-) mice, into CD4+ 8+ TID815 ... immunized mice abolished otherwise inevitable development of antitumor immunity. Taken together, our findings provide an ...
Studying differential responses of inbred mouse lines with distinct genetic backgrounds to... ... showed distinct expression patterns between C57BL/6J and DBA/2J mice. (B) PCA of all samples based on normalized counts of ... Integrated analysis of mRNA-seq and miRNA-seq for host susceptibilities to influenza A (H7N9) infection in inbred mouse lines. ... Influenza (H7N9) virus Host susceptibilities mRNA-seq miRNA-seq Inbred mouse lines Temporal dynamics ...
Inbred mice exhibited distinct differences in the development of diabetic albuminuria. Diabetic DBA/2J and KK/HlJ mice appear ... GFR in diabetic inbred mice.. GFR was serially examined in diabetic inbred mice and age-matched controls using FITC-inulin ... Induction of diabetes in inbred mice.. At 10 weeks of age, inbred mice received daily STZ injections intraperitoneally (40 mg/ ... DBA/2J (25 weeks after STZ). F: Arteriolar hyalinosis (arrow) in diabetic DBA/2J mice. G: KK/HlJ mice (35 weeks after STZ). H: ...
Other mouse models in which serotonergic signaling was disrupted during development showed similar morphological changes in the ... Other mouse models in which serotonergic signaling was disrupted during development showed similar morphological changes in the ... So far, analysis of the 5-HT3A knockout mouse revealed changes in nociceptive processing and a reduction in anxiety related ... Here, we subjected male and female 5-HT3A knockout mice and their non-transgenic littermates to several tests of social ...
The first inbred strain, DBA (dilute brown agouti), was developed in 1909. Among the earliest references to the use of inbred ... MMHCdb contains genetic and genomic information about inbred mouse strains, genetically engineered mouse models (GEMMs) and ... Inbred mouse strains are the result of at least 20 generations of successive brother/sister matings which lead to a population ... Inbred strains of mice allow researchers to investigate the role that genetics plays in cancer susceptibility and treatment ...
... a 4.8-Mb region on mouse chromosome one in eight inbred strains (C57BL/6J, C3H/HeJ, DBA/2J, A/J, BALB/cJ, AKR/J, RIII/DmMobJ, ... in comparisons between inbred strains. We report a detailed analysis of polymorphism distribution in multiple inbred mouse ... Unexpected complexity in the haplotypes of commonly used inbred strains of laboratory mice. B. Yalcin, J. Fullerton, S. Miller ... Our observations do not invalidate attempts to map QTL by using the mosaic structure of sequence variation in inbred mouse ...
Shelton, K. L., and Grant, K. A. (2002). Discriminative stimulus effects of ethanol in C57BL/6J and DBA/2J inbred mice. Alcohol ... Discriminative stimulus effects of 5.6 mg/kg pregnanolone in DBA/2J and C57BL/6J inbred mice. Alcohol 37, 35-45. ... of the discriminative stimulus effects of the neuroactive steroid pregnanolone in DBA/2J and C57BL/6J inbred mice. J. Pharmacol ... or male mice (49 pg/ml), but 3α,5α-THP, 3α,5β-THP, and 3α,5α-THDOC were much lower in cynomolgus monkeys compared to rats, mice ...
2003a Quantitative trait loci that determine lipoprotein cholesterol levels in DBA/2J and CAST/Ei inbred mice. J. Lipid Res. 44 ... The P × I cross includes 305 mice genotyped at 107 markers; P × D has 324 mice and 97 markers; C × D has 278 mice and 109 ... Beck, J. A., S. Lloyd, M. Hafezparast, M. Lennon-Pierce, J. T. Eppig et al., 2000 Genealogies of mouse inbred strains. Nat. ... Inbred laboratory mouse strains are known to have originated from a mixed but limited founder population (Silver 1995; Becket ...
Genetic, ethanol and the Fos response: a comparison of the C57BL/6J and DBA/2J inbred mouse strains. Alcohol Clin Exp Res 21: ... Prenatal alcohol exposure causes long-term serotonin neuron deficit in mice. Alcohol Clin Exp Res 28: 941-948.. *Wiley Online ... Next article in issue: Microstructure of trabecular bone in a mouse model for down syndrome Next article in issue: ... Anxiety and stress responses in female oxytocin deficient mice. J Neuroendocrinol 16: 319-324.. *Wiley Online Library , ...
DBA/1 mice were immunized with CFA only, with CII/CFA or left untreated. At days 10 (CFA and CFA/CII) ... Mice. *Mice, Inbred C57BL. *Mice, Inbred DBA. *Neutralization Tests. *Polymerase Chain Reaction ... mice as well as to mice 25 days p.i and CIA-diseased mice (Figure 1A). However, injection of CFA only also induced a clear ... mice as well as to mice 25 days p.i and CIA-diseased mice (Figure 1A). However, injection of CFA only also induced a clear ...
  • Twelve male and female DBA/2J mice and 12 male and female C57BL/6J mice were trained to discriminate 10 mg/kg pregnanolone from saline. (aspetjournals.org)
  • The male C57BL/6J mice had to be removed from the study due to increased seizures apparently associated with the chronic intermittent pregnanolone administration used in drug discrimination. (aspetjournals.org)
  • In DBA/2J and C57BL/6J mice, a benzodiazepine, barbiturate, and GABAergic neuroactive steroids all substituted for the stimulus effects of pregnanolone. (aspetjournals.org)
  • The present data suggest that many of the previously documented neurosteroid-induced behavioral differences between the DBA/2J and C57BL/6J are acute effects and are not apparent in a drug discrimination procedure. (aspetjournals.org)
  • The effects of naltrexone on the increase in locomotor activity induced by a low dose (1.35 g/kg IP) of ethanol and on the duration of loss of righting reflex after a high dose (3.5 g/kg) of ethanol were studied in BALB/c, DBA/2, and C57BL/6 mice. (isharonline.org)
  • Ethanol increased locomotor activity in DBA and BALB mice, but not in C57BL mice. (isharonline.org)
  • DBA/2J or D2) but not all (C57BL/6J or B6) inbred strains of mice, ethanol has a marked psychostimulant effect. (elsevier.com)
  • and C57BL-mice, about 20% affected. (aappublications.org)
  • First, it does not explain why cortisone regularly induces cleft palate in DBA-and C57BL-mice, which never have cleft lip and only extremely rarely have cleft palate, spontaneously. (aappublications.org)
  • the offspring of pregnant strain-A females fed galactoflavin only rarely have cleft palate, whereas offspring of treated DBA- and C57BL-females have moderately low to moderately high incidences of this anomaly. (aappublications.org)
  • Five inbred strains of mice were tested, C57BL/6J, DBA/2J, FVB/NJ, A/J and B6129PF2/J hybrids. (nih.gov)
  • Here we describe differences in the cortical area map of two commonly used inbred strains of laboratory mice, C57BL/6J and DBA/2J. (beds.ac.uk)
  • The sample of C57BL/6J and DBA/2J mice can be discriminated with 90% accuracy on the basis of these three size dimensions. (beds.ac.uk)
  • C57BL/6J and DBA/2J have markedly different cortical area maps, suggesting that inbred strains harbor enough phenotypic variation to encourage a forward genetic approach to understanding cortical development, complementing other approaches. (beds.ac.uk)
  • The inbred mouse strains, DBA/2J (D2) and C57BL/6J (B6), display differential sensitivity to acute, thermal nociception as measured on the hot-plate (HP) assay. (elsevier.com)
  • We previously described planar areal differences in adult mouse visual, somatosensory, and neocortex that collectively discriminated C57BL/6J and DBA/2J inbred strain identity. (beds.ac.uk)
  • We compared the variation in shape between C57BL/6J and DBA/2J relative to that within each strain using a permutation test of Goodall's F statistic. (beds.ac.uk)
  • C57BL/6J and DBA/2J have markedly different cortical area maps, in both size and shape. (beds.ac.uk)
  • We previously demonstrated significant differences in the size of both V1 (12%) and the PMBSF (10%) between the inbred strains C57BL/6J and DBA/2J [ 6 ]. (beds.ac.uk)
  • Here, we utilized an integrated approach of mRNA-seq and miRNA-seq to investigate the transcriptome expression and regulation of host genes in C57BL/6J and DBA/2J mouse strains during influenza virus infection. (springer.com)
  • The differential pathogenicity of influenza virus in C57BL/6J and DBA/2J has been fully demonstrated through immunohistochemical staining, histopathological analyses, and viral replication assessment. (springer.com)
  • Supplementary Fig. S3 showed the characteristics of genes differentially expressed between C57BL/6J and DBA/2J over time. (springer.com)
  • A) Heatmap of genes differentially expressed between strains (strain-specific DEGs) showed distinct expression patterns between C57BL/6J and DBA/2J mice. (springer.com)
  • The present studies characterized the severity of diabetic nephropathy in six inbred mouse strains including C57BL/6J, DBA/2J, FVB/NJ, MRL/MpJ, A/J, and KK/HlJ mice. (diabetesjournals.org)
  • DBA/2J and KK/HlJ mice developed significantly more albuminuria than C57BL/6J, MRL/MpJ, and A/J mice. (diabetesjournals.org)
  • DBA/2J and KK/HlJ mice are more prone to diabetic nephropathy, whereas the most widely used C57BL/6J mice are relatively resistant to development of diabetic nephropathy. (diabetesjournals.org)
  • For example, transgenic mice on a mixed C57BL/6J and SJL background expressing human HRAS have a mammary gland carcinoma frequency of 45-50% whereas the same transgene expressed in FVB/N mice result in 100% of the animals having mammary gland carcinomas. (wikipedia.org)
  • Origin: Mutation to mk (microcytic anaemia) in descendents of a cross between C57BL/6J and DBA/2J. (jax.org)
  • Three inbred strains (C57BL/1O, DBA/1, and Bulb/c) differ with regard to this asymmetry. (sciencemag.org)
  • Two common strains of laboratory mice, C57BL/6J and DBA/2J, have telomeres several times longer than most other mammals surveyed. (mendeley.com)
  • Telomeres of all three inbred lines are significantly lengthened relative to outbred P. leucopus, and the three lines display strain-specific significantly different telomere lengths, much like the C57BL/6J and DBA/2J strains of M. musculus. (mendeley.com)
  • The BXD#/Rww recombinant inbred (RI) strains originate from crosses between C57BL/6J ( 000664 ) females and DBA/2J ( 000671 ) males and were generated using a strategy of advanced intercrosses (AI). (jax.org)
  • The BXD#/Rww advanced recombinant inbred (ARI) lines are derived from two independently derived advanced intercrosses between the C57BL/6J and DBA/2J progenitor strains generated at Princeton University and the University of Tennessee. (jax.org)
  • Mice from the Princeton set have a Y chromosome from DBA/2J and the mitochondrial genome from C57BL/6J. (jax.org)
  • This family is an admixture of C57BL/6J and DBA/2J genomes, and the family are segregating for roughly 5.5 million sequence variants 22 . (nature.com)
  • In 1921, C57BL became one of the most widely used mice in genetics and was the first strain to have its genome sequenced. (wikipedia.org)
  • We examined the effects of ethanol on gait in C57BL/6J (B6) and DBA/2J (D2) mice walking at a speed of 25 cm/sec. (nih.gov)
  • Two strains, DBA/2J and C57BL/6J, differed in trait and restraint-induced anxiety-related behavior (dark/light exploration, elevated plus maze). (jneurosci.org)
  • Gene expression analysis of amygdala, medial prefrontal cortex, and hippocampus revealed divergent expression in DBA/2J and C57BL/6J both at baseline and after repeated restraint. (jneurosci.org)
  • Repeated restraint augmented amygdala excitatory postsynaptic signaling and altered metaplasticity (temporal summation of NMDA receptor currents) in DBA/2J but not C57BL/6J. (jneurosci.org)
  • The BXD genetic reference panel is a set of recombinant inbred mouse strains derived from crossing the C57BL/6J and DBA/2J inbred strains. (alzforum.org)
  • Interval mapping was used to locate quantitative trait loci (QTLs) using recombinant inbred strains and F2 intercrosses between strains C57BL/6J and DBA/2J. (nervenet.org)
  • Previously, besides the considered Swiss Webster mice, only two inbred strains (C57Bl/6, DBA/2) were investigated for the presence of helminths in Brazil (Pinto et al. (scielo.br)
  • The group B was represented by the strains C57Bl/6, CBA, BALB/c and C3H/He, with 25 mice each. (scielo.br)
  • In the study regarding the prevalence of species, the strains C57Bl/6, C57Bl/10 and C3H/He showed high percentages (88-96%) for A. tetraptera , whereas BALB/c, DBA/2 and C3H/He presented higher prevalence (80-100%) for S . obvelata , while the prevalence of V. nana was higher (92%) in the C3H/He strain. (scielo.br)
  • A. tetraptera was associated to V. nana in C57Bl/6, C57Bl/10 and C3H/He mice. (scielo.br)
  • Scriptaid enables the clone of all the important inbred mouse strains, such as C57BL/6, C3H/He, DBA/2, and 129/Sv. (selleckchem.com)
  • the 5XFAD females used for these crosses were hemizygous for the transgenes on an inbred C57BL/6J background. (alzforum.org)
  • The nucleotide sequences of several genes reported to be associated with the risk of sporadic, late-onset AD (LOAD) differ somewhat between C57BL/6J and DBA/2J mice. (alzforum.org)
  • Fifty-two C57BL/6J:DBA/2J (B6D2)F2 hybrids were phenotyped for haloperidol response before determination of TH cell number. (aspetjournals.org)
  • Neonatal C57BL/6J mice housed in a specific-pathogen free facility received increasing doses of fructooligosaccharide (FOS) solution or deionized, distilled water. (peerj.com)
  • Ssm1 family members in C57BL/6 (B6) and DBA/2 (D2) mice have various amino acid changes in their ZF domain and in the linker between the KRAB and ZF domains. (biologists.org)
  • When HRD is carried in certain inbred strains of mice ( Mus musculus ), such as C57BL/6 (B6), it is highly methylated at CpG nucleotides. (biologists.org)
  • We reasoned that the orexigenic action of NPY would be evident in C57Bl/6J mice susceptible to obesity. (diabetesjournals.org)
  • C57Bl/6J mice lacking NPY are also less susceptible to diet-induced obesity (DIO) as a result of reduced feeding and increased energy expenditure. (diabetesjournals.org)
  • Despite the strong pharmacological evidence supporting its role in energy balance, genetic disruption of NPY did not affect feeding or body weight in mice bred on a mixed 129J-C57Bl/6J background ( 2 ). (diabetesjournals.org)
  • We hypothesized that the importance of NPY in energy homeostasis would be evident in C57Bl/6J mice prone to obesity ( 12 , 14 ). (diabetesjournals.org)
  • Breeder Npy +/− mice on a mixed 129SvEv-C57Bl/6J background were provided by Richard Palmiter (University of Washington, Seattle, WA) and were backcrossed for 10 generations onto the C57BL/6J background (The Jackson Laboratories, Bar Harbor, ME). (diabetesjournals.org)
  • Inbred strains of mice can be classified into 3 categories according to their resistance to infection with S.typhimurium: susceptible (BALB/c, C57BL/6, C3H/He), intermediate (DBA/2, C75L) and resistant (A, CBA). (fishersci.com)
  • Strikingly, across a multidimensional set of 115 behavioral parameters, several strains consistently ranked high in within-strain variability (DBA/2J, 129S1/Sv A/J and NOD/LtJ), whereas other strains ranked low (C57BL/6J and BALB/c). (uva.nl)
  • C57BL/6 mice) develop symptoms of severe malaria and CM, including cytokine-associated encephalopathy, acidosis, coagulopathy, shock, and pulmonary edema, culminating in a fatal outcome ( 3 - 5 ). (rupress.org)
  • In previous mouse breeding studies between these DCC susceptible and the DCC-resistant strain C57BL/6J, 4 genetic loci harboring genes involved in DCC inheritance were identified and subsequently termed Dyscalc loci 1 through 4. (deepdyve.com)
  • In addition to using the currently available RI strains, we have recently developed 45 additional BXD RI strains using two advanced intercross lines between C57BL/6 and DBA/2 mice as progenitors. (uthsc.edu)
  • Belknap and colleagues (1992) used the BXD RI strains to map QTLs responsible for brain weight differences between DBA/2J and C57BL/6J (Belknap, 1992). (nervenet.org)
  • The BXD set consisted of 26 strains that were generated from parental strains, DBA/2J and C57BL/6J, which have a 73 mg difference in brain weight. (nervenet.org)
  • The AXB, BXA RI strains were produced from reciprocal crosses between the inbred strains A/J and C57BL/6J. (nervenet.org)
  • Mixtures, (50-50), of C57BL/6 and DBA/2 mouse leucocytes were cultured in medium containing low amounts of mouse plasma and supplemented with foetal bovine serum. (dtic.mil)
  • Pubmed ID: 16842828 In the present study, we compared the maternal and non-maternal behaviors of primiparous females in both the light and dark phases during 3 weeks postpartum in five inbred strains of mice (BALB/c, CBA/Ca, C3H/He, C57BL/6, and DBA/2) to examine the strain differences in the behaviors in detail. (jove.com)
  • To determine whether the enhanced influenza virus susceptibility is due to intrinsically reduced antiviral activity of the CAST-derived Mx1 allele, we generated a congenic C57BL/6J mouse line that carries the Mx locus of CAST/EiJ mice. (asm.org)
  • Adult animals of this line were almost as susceptible to influenza virus challenge as standard C57BL/6J mice lacking functional Mx1 alleles but exhibited far more pronounced resistance to Thogoto virus. (asm.org)
  • Intracerebral infection with Theiler's murine encephalomyelitis virus (TMEV) induces immune-mediated demyelinating disease in susceptible SJL/J mice but not in resistant C57BL/6 mice. (asm.org)
  • In this study, we used C57BL/6.S (B6.S) congenic mice, which carry H-2 s MHC genes instead of H-2 b MHC genes in conjunction with the C57BL/6 (B6) background genes. (asm.org)
  • We sequenced the two most commonly used inbred mouse strains, DBA/2J and C57BL/6J, across a region of chromosome 1 (171.6 - 174.6 megabases) using two next generation high-throughput sequencing platforms: Applied Biosystems (SOLiD) and Illumina (Genome Analyzer). (biomedcentral.com)
  • Comparisons utilizing even two of the best characterized mouse genetic models, DBA/2J and C57BL/6J, indicate that more than half of naturally-occurring SNPs remain cryptic. (biomedcentral.com)
  • Importantly, this is a lower bound estimate because the C57BL/6J (B6) strain, used for the mouse genome reference sequence (NCBI m37, Apr 2007), is the only mouse strain sequenced in its entirety. (biomedcentral.com)
  • In this study, to map genetic regions responsible for the susceptibility of spermatozoa to freezing-thawing, we performed in vitro fertilization using spermatozoa from recombinant inbred mice derived from the C57BL/6J and DBA/2J strains, whose spermatozoa showed distinct fertilization abilities after freezing. (go.jp)
  • Specifically, the Abl2 gene on chromosome 1, which may affect subcellular actin distribution, had polymorphisms between C57BL/6J and DBA/2J that caused at least three amino acid substitutions. (go.jp)
  • The B6D2F1 mice that served as a source of normal BMC are offspring of a cross between glaucoma prone D2 and normal C57BL/6J (B6) mice. (biomedcentral.com)
  • DBA/2J and C57BL/6J mice were placed in cylindrical restrainers after injection of 3 g/kg (20% v/v) ethanol. (mendeley.com)
  • On the other hand, DBA/2J mice recovered at higher BEC than C57BL/6J animals. (mendeley.com)
  • Naltrexone, at a dose of 0.1 mg/kg, antagonized the ethanol-induced increase in locomotion similarly in DBA and BALB mice. (isharonline.org)
  • Our studies indicate that the BALB/cJ inbred strain shows reduced sociability and other behavioral and neurobiological traits relevant to autism (Brodkin, in press). (upenn.edu)
  • A new set of studies in our laboratory is aimed at elucidating the brain pathways that underlie this reduced sociability of BALB/cJ mice. (upenn.edu)
  • BALB/cJ, DBA/2J), but less so in others (e.g. (jneurosci.org)
  • Balb/C, C3H, DBA/2) are also highly susceptible to infection ( 1 , 6 , 7 ). (cdc.gov)
  • In another study in which male BALB/c mice were maintained for one year on a BHT-free diet, or diets containing 0.05% BHT or 0.5% BHT, the incidences of liver tumours were 4/30 (131), 6/43 (14%), and 2/28 (7%) for the respective groups (Lindenschmidt et al . (inchem.org)
  • We surveyed variation in miRNA abundance in the hippocampus of mouse inbred strains, allowing us to take a genetic approach to the study of miRNA regulation, which is novel for miRNAs. (essex.ac.uk)
  • The BXD recombinant inbred panel is a very well characterized genetic reference panel which allows quantitative trait locus (QTL) analysis of miRNA abundance and detection of correlates in a large store of brain and behavioural phenotypes. (essex.ac.uk)
  • In an ongoing quantitative trait locus (QTL) mapping study designed to reveal genomic loci showing genetic linkage to HP sensitivity, a putative QTL on chromosome 4 (50-80 cM from the centromere) has been identified that appears to account for variability in this trait in male, but not female mice. (elsevier.com)
  • These data support the possibility that Oprd1 is a QTL mediating HP sensitivity in mice, and more generally illustrate the important roles of genetic background and gender in the perception of pain. (elsevier.com)
  • Comparing cortical phenotypes between normally varying inbred mice or between genetically modified mice can identify genetic contributions to cortical specification. (beds.ac.uk)
  • Experimental genetic manipulations have produced spectacular alterations in the position, size, and shape of primary sensory and motor areas of the mouse neocortex, leading to the conclusion that cortical arealization results in part from intrinsic cortical genetic mechanisms acting early in development [ 1 - 4 ]. (beds.ac.uk)
  • The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. (jax.org)
  • Studying differential responses of inbred mouse lines with distinct genetic backgrounds to influenza virus infection could substantially increase our understanding of the contributory roles of host genetic factors to disease severity. (springer.com)
  • Inbred mice have been wildly used to model human diseases not only because they facilitate gene manipulation, but also because they share high genetic homology with humans ( 9 - 11 ). (diabetesjournals.org)
  • Many mouse models of diabetes have been established including type 1 diabetes due to streptozotocin (STZ) treatment and genetic models (e.g. (diabetesjournals.org)
  • The laboratory mouse has physiology and genetic characteristics very similar to humans providing powerful models for investigation of the genetic characteristics of disease. (wikipedia.org)
  • MMHCdb contains genetic and genomic information about inbred mouse strains, genetically engineered mouse models (GEMMs) and Patient Derived Xenograft (PDX) models of human cancer. (wikipedia.org)
  • Inbred mouse strains are the result of at least 20 generations of successive brother/sister matings which lead to a population with minimal segregating genetic variation. (wikipedia.org)
  • The genetic background of genetically modified animals can influence the observed phenotypes and must be taken into account when mouse models of human cancer are developed and when interpreting the data generated by these models. (wikipedia.org)
  • Rodent inbred line crosses are widely used to map genetic loci associated with complex traits. (genetics.org)
  • Detection of a QTL with desirable power and accuracy in an inbred line cross depends on the genetic diversity between the parental strains, heritability of the trait, the size of the cross, and the density of genetic markers ( K ao and Z eng 1997 ). (genetics.org)
  • Rodent inbred lines can model human disease traits and inbred line crosses provide a powerful approach to mapping the genetic loci associated with these diseases ( P aigen 1995 ). (genetics.org)
  • Cohen, H. , Geva, A.B. , Matar, M.A. , Zohar, J. & Kaplan, Z. ( 2008 ) Post-traumatic stress behavioural responses in inbred mouse strains: can genetic predisposition explain phenotypic vulnerability? (wiley.com)
  • Moreover, the two inbred laboratory mouse strains display significantly different telomere lengths, suggesting the existence of strain-specific genetic determinants. (mendeley.com)
  • To further characterize the genetic inheritance of telomere length, we carried out several crosses to obtain hybrid F(1) mice between parental strains displaying the phenotype of long and short telomeres. (mendeley.com)
  • Independent genetic loci for sensorimotor gating and attentional performance in BXD recombinant inbred strains. (jax.org)
  • Mammary cancers in mice can be caused by genetic mutations that have been identified in human cancer. (wikipedia.org)
  • B6 and D2 are two inbred strains that are widely used to study the genetic influences of ethanol on motor function. (nih.gov)
  • Currently, most of our genetic studies of social behaviors use the mouse as a model organism, because of the experimental control that a model organism provides, and because of the many resources available for mouse genetics. (upenn.edu)
  • Inbred mouse strains provide a relatively stable and restricted range of genetic and environmental variability that is valuable for disentangling gene-stress interactions. (jneurosci.org)
  • A panel of different mouse strains represents a significant but restricted degree of genetic diversity in which environmental variance can be carefully controlled. (jneurosci.org)
  • Differences in accumulation of renal Hg between inbred mouse strains suggest a genetic inter-strain variation regulating retention or/and excretion of Hg. (diva-portal.org)
  • Denaturing HPLC, next generation sequencing, conserved region analysis and genetic mouse strain comparison were used for haplotyping and fine mapping on QTLs associated with Hg concentration in kidney, development of ANoA and serum IgG1 hypergammaglobulinemia. (diva-portal.org)
  • several genetic mutations causing obesity and diabetes syndromes in mice have been described ( 2 , 9 , 13 , 18 , 20 ). (physiology.org)
  • AD-BXD" refers to a panel of transgenic mouse strains, created by crossing 5XFAD mice to members of the BXD genetic reference panel. (alzforum.org)
  • Here we explore the genetic basis of variation in eye size in mice and specifically map genes that modulate eye weight, lens weight, and retinal surface area. (nervenet.org)
  • We had previously demonstrated genetic variation of this trait among inbred mouse strains. (aspetjournals.org)
  • These results demonstrate the potential for genetic variation arising from factors other than CYP1A2 activity to influence the plasma paraxanthine/caffeine ratio in mice. (aspetjournals.org)
  • The laboratory mouse offers the opportunity to study genetic variation in gene expression in the absence of differential exposure to environmental inducers. (aspetjournals.org)
  • Phenotypic differences among inbred mouse strains can be exploited to identify genetic differences in the expression of genes underlying the trait under consideration. (aspetjournals.org)
  • In this chapter, we suggest that mouse models are useful for studying genetic background effects for acquired hearing loss. (intechopen.com)
  • The genetic analysis of mouse models identified the genetic modifiers. (intechopen.com)
  • We review the genetic research in mouse models for acquired hearing loss to identify and confirm the modifiers by both forward and reverse genetics approaches. (intechopen.com)
  • AD-BXD" refers to a panel of transgenic mouse strains, created to model the genetic diversity seen in human populations. (alzforum.org)
  • These mice represent a unique resource for scientists seeking to identify genetic factors that influence resilience or vulnerability to AD, examining the interactions between genetic and environment factors, or wishing to conduct preclinical studies in an animal population that incorporates genetic heterogeneity that better reflects human populations. (alzforum.org)
  • When a genetic risk score was assigned to each AD-BXD strain, based on polymorphisms in 21 LOAD-associated genes, this score was found to correlate with cognitive function in 14-month-old transgenic AD-BXD mice, but not their non-transgenic littermates. (alzforum.org)
  • The genetic basis of variation in eye size in mice was explored, and genes that modulate eye weight, lens weight, and retinal area were mapped. (arvojournals.org)
  • These advances include (i) a quadrupling of the density of the genetic map of the mouse, (ii) the ease of genotyping large numbers of marker loci distributed across the entire mouse genome by the polymerase chain reaction, (iii) a far more powerful conceptual framework for mapping quantitative trait loci (QTLs) that underlie complex genetic traits, and (iv) significantly more reliable and economical ways to estimate numbers of neurons. (nervenet.org)
  • Neuropeptide Y (NPY) stimulates feeding and weight gain, but deletion of the NPY gene does not affect food intake and body weight in mice bred on a mixed genetic background. (diabetesjournals.org)
  • We reasoned that the controversies surrounding the actions of NPY in these genetic models are partly due to the use of the 129 mouse strain, which is resistant to obesity ( 12 ). (diabetesjournals.org)
  • Together, these show that genetically inbred mouse strains consistently differ in phenotypic robustness against environmental variation, suggesting that genetic factors contribute to variation in robustness. (uva.nl)
  • Experimental infection of inbred and congenic mice with Plasmodium berghei ANKA (PbA) provides a well-established model to identify host genetic determinants that regulate both protective immunity and infection-associated immunopathology, including the development of CM. Similar to P. falciparum infection in humans, mice susceptible to PbA (e.g. (rupress.org)
  • In order to determine molecular pathways involved in the development of glaucoma, differential gene expression analysis was used to identify genetic markers associated with the pathogenesis of glaucoma in a mouse model. (umassmed.edu)
  • The study also highlights the power of GWAS in the mouse for dissecting complex genetic traits. (deepdyve.com)
  • I use recombinant inbred (RI) mice and microarrays to study the several brain-related genetic problems. (uthsc.edu)
  • Given the proliferation of mouse genetic models (e.g., knockout models, selectively bred lines, heterogeneous stocks derived from standard inbred strains and wild mice) and the wealth of gene expression microarray and phenotypic studies using genetic models, the impact of naturally-occurring polymorphisms on these data is critical. (biomedcentral.com)
  • This warrants full genomic sequencing of the mouse strains used as genetic models. (biomedcentral.com)
  • Although it is known that the susceptibility of mouse spermatozoa to freezing-thawing varies greatly with genetic background, the underlying mechanisms remain to be elucidated. (go.jp)
  • Differential susceptibility to diabetic nephropathy has been observed in humans, but it has not been well defined in inbred strains of mice. (diabetesjournals.org)
  • Taken together, these results indicate that differential susceptibility to diabetic nephropathy exists in inbred mice. (diabetesjournals.org)
  • Inbred strains of mice allow researchers to investigate the role that genetics plays in cancer susceptibility and treatment response. (wikipedia.org)
  • Among the earliest references to the use of inbred mice in cancer was the observed susceptibility of the A family of inbred mice to spontaneous lung tumors. (wikipedia.org)
  • Our data suggest that the higher susceptibility of D2 compared with B6 mice to the effects of ethanol on motor function may be attributed to less stable basal gait characteristics that are perturbed by ethanol. (nih.gov)
  • Here, we report susceptibility to cardiac fibrosis, a sub-phenotype of DCC, at 12 and 20 months of age and close to natural death in a survey of 28 inbred mouse strains. (deepdyve.com)
  • Most other laboratory inbred mouse strains carry truncated nonfunctional Mx1 alleles and, consequently, exhibit high virus susceptibility. (asm.org)
  • Thus, the enhanced influenza virus susceptibility of CAST/EiJ mice can be explained by minor alterations in the MX1 restriction factor that negatively affect its enzymatic activity and reduce its half-life. (asm.org)
  • IMPORTANCE This study indicates that innate immune cytokines produced in antigen-presenting cells stimulating the T cell immune responses during early viral infection play a critical role in determining the susceptibility of mice to the development of demyelinating disease. (asm.org)
  • They suggest that affects of Gpnmb on innate immunity influence susceptibility to glaucoma in DBA/2J mice. (biomedcentral.com)
  • In 1909, Clarence C. Little developed the first inbred strain, the DBA (Dilute, brown non-Agouti) mouse. (wikipedia.org)
  • DBA/2J exhibits many unique anatomical, physiological, and behavior traits. (biomedcentral.com)
  • The Brodkin laboratory studies the neurobiology and genomics of social behavior development in mouse models relevant to autism. (upenn.edu)
  • Social behavior phenotypes in fragile X syndrome, autism, and the Fmr1 knockout mouse: Theoretical comment on McNaughton et al. (upenn.edu)
  • So far, analysis of the 5-HT 3A knockout mouse revealed changes in nociceptive processing and a reduction in anxiety related behavior. (frontiersin.org)
  • Other mouse models in which serotonergic signaling was disrupted during development showed similar morphological changes in the cortex, and in addition, also deficits in social behavior. (frontiersin.org)
  • Here, we subjected male and female 5-HT 3A knockout mice and their non-transgenic littermates to several tests of social behavior. (frontiersin.org)
  • These results indicate that the 5-HT 3A knockout mouse displays impaired social behavior with specific changes in males and females, reminiscent to other mouse models in which serotonergic signaling is disturbed in the developing brain. (frontiersin.org)
  • Apart from a decreased sensitivity to formalin induced pain, 5-HT 3A knockout mice did not exhibit abnormalities in body weight, food, or water intake, sexual behavior, or motor function during rotarod performance. (frontiersin.org)
  • In this study, we sought to determine whether the 5-HT 3A receptor knockout mouse displays similar forms of impaired social behavior. (frontiersin.org)
  • Mammary tumors compromise time-of-day differences in hypothalamic gene expression and circadian behavior and physiology in mice. (neurotree.org)
  • Repeated Social Defeat in Female Mice Induces Anxiety-Like Behavior Associated with Enhanced Myelopoiesis and Increased Monocyte Accumulation in the Brain. (neurotree.org)
  • One of the simplest meaningful behavior genetics experiments with mice is to compare multiple inbred strains on the same task. (nap.edu)
  • While rodent models are a useful method for determining causal relationships between HMO, gut microbiota, and behavior, murine studies of gut microbiota usually employ oral gavage, a technique stressful to the mouse. (peerj.com)
  • Within-strain variation in behavior differs consistently between common inbred strains of mice. (uva.nl)
  • Strain rankings of within-strain variability in behavior were confirmed in an independent, previously published behavioral dataset using conventional behavioral tests administered to different mice from the same breeding colonies. (uva.nl)
  • Maternal Behavior of Primiparous Females in Inbred Strains of Mice: a Detailed Descriptive Analysis Physiology & Behavior. (jove.com)
  • Inbred strains of laboratory mice can be exploited to study cortical area map formation if there are significant phenotypic differences with which to correlate gene polymorphism or expression data. (beds.ac.uk)
  • 6 ] have employed gene expression array analysis of the dissected embryonic (16.5d) mouse cerebral cortex to expand the list of genes regionally expressed, and noted that regional differences in expression of genes in the cortical plate should eventually convert into functionally distinct cortical areas with anatomically distinguishable borders after birth. (beds.ac.uk)
  • Here we use a novel application of established methods of two-dimensional geometric morphometrics to examine shape differences in the cortical area maps of these inbred strains. (beds.ac.uk)
  • Significant differences in shape in the posterior medial barrel subfield (PMBSF), as well as differences in shape across primary sensory areas, characterize the cortical area maps of these common inbred, isogenic strains. (beds.ac.uk)
  • Similar differences may be present between standard inbred strains of mice. (beds.ac.uk)
  • We sequenced the genome of DBA/2J using SOLiD and Illumina high throughput short read protocols to generate a comprehensive set of ~5 million sequence variants segregating in the BXD family that ultimately cause developmental, anatomical, functional and behavioral differences among these 80+ strains. (biomedcentral.com)
  • Moreover, we observed differences in preference for social novelty for male and female 5-HT 3A knockout mice during the social approach test. (frontiersin.org)
  • Second, QTL mapping can be carried out by associating phenotypic variation in inbred strains with their strain distribution pattern (SDP) [ in silico mapping ( 8 )], where an SDP is the pattern of allelic similarities and differences among strains at a locus. (pnas.org)
  • For this purpose, we initially tried to determine the protein level in multiple tissues, including thyroid tissues, using immunoblot analysis, but we did not detect any significant differences between the controls and the mutant mice. (nih.gov)
  • Differences in gait indices between the two strains of mice were more pronounced of the forelimbs with the highest dose of ethanol (2.75 g/kg). (nih.gov)
  • In addition to our work on aggressive behaviors, we have demonstrated differences among inbred mouse strains in sociability, using a social choice behavioral paradigm (Brodkin et al. (upenn.edu)
  • Previous studies have found differences in various "emotion-related" phenotypes across inbred strains. (jneurosci.org)
  • TH cell number showed significant differences among inbred strains, with the largest difference (88%) noted between the 129/J and P/J strains in the rostral SNZc. (aspetjournals.org)
  • In the VTA, differences as large as 95% were noted (AKR/crl vs. P/J). Among the inbred strains, there was no significant relationship between cell number and response except in the medial SNZc, where the most responsive strains had the highest cell number. (aspetjournals.org)
  • Additionally, we found significant differences between the fecal microbiota from handled and non-handled mouse pups. (peerj.com)
  • Likewise, there were no differences in blood pressure between mPGES1-deficient and wild-type mice on control or high- or low-salt diets. (asnjournals.org)
  • K5-mTert transgenic mice overexpress telomerase in a wide spectrum of tissues. (isharonline.org)
  • 5 ] demonstrated changes in the position and or size of primary sensory visual, somatosensory, and auditory cortical regions in transgenic mice over expressing the transcription factor Emx2 . (beds.ac.uk)
  • Because of the extensive changes in the cortical area map of transgenic Emx2 mice, the quantitative descriptions used by Hamasaki et al. (beds.ac.uk)
  • In 1982, Palmiter and Brinster implanted a foreign gene into fertilized egg, finally generating the first transgenic mice genetically engineered to express dominant oncogenes. (wikipedia.org)
  • Transgenic mice overexpressing superoxide dismutase (SOD) 1 (tg-SOD), which maintain high ambient H 2 O 2 , have also been shown to be impaired in their ability to express hippocampal LTP. (jneurosci.org)
  • Transgenic AD-BXD mice develop amyloid plaques by 6 months of age, although the extent of plaque deposition is strain-dependent. (alzforum.org)
  • Transgenic AD-BXD mice exhibit cognitive deficits, assessed using contextual fear conditioning. (alzforum.org)
  • in the AD-BXD population as a whole, transgenic mice were cognitively normal at 6 months, but impaired at 14 months. (alzforum.org)
  • Both transgenic and non-transgenic mice show age-related deterioration of sensorimotor function, but the presence of the transgenes exacerbates this decline. (alzforum.org)
  • More broadly, genes related to neuronal activity, structure, and function were downregulated in transgenic mice, while genes related to immune responses were upregulated. (alzforum.org)
  • Finally, we explore the method's performance in computer simulations, and we illustrate its use through application to a set of four mouse intercrosses among five inbred strains, with data on HDL cholesterol. (genetics.org)
  • Our strategy is motivated by the hypothesis that common inbred strains of the laboratory mouse are derived from a limited ancestral gene pool and thus QTL detected in multiple crosses are likely to represent shared ancestral polymorphisms. (genetics.org)
  • With the introduction of temporal expression pattern analysis, we demonstrated that host factors responsible for influenza virus replication and host-virus interaction were significantly enriched in genes exhibiting distinct temporal dynamics between different inbred mouse lines. (springer.com)
  • MMHCdb provides interactive graphical summaries of the characteristic cancers observed in over 700 different inbred mouse strains. (wikipedia.org)
  • If single-nucleotide polymorphisms (SNPs) are randomly distributed across the genomes of inbred strains, mapping QTL by SDP association with phenotype will require a very dense set of markers, but if the distribution is segmented, then a few markers will be sufficient to identify common haplotypes. (pnas.org)
  • The seemingly normal phenotype of NPY-deficient mice could also result from compensatory developmental changes. (diabetesjournals.org)
  • The laboratory mouse has been instrumental in investigating the genetics of human disease, including cancer, for over 110 years. (wikipedia.org)
  • The mouse tumor biology database: a public resource for cancer genetics and pathology of the mouse" (PDF). (wikipedia.org)
  • The BXD recombinant inbred (RI) strains are used to study the genetics of behavioral phenotypes including alcohol and drug addiction, stress, and locomotor activity. (jax.org)
  • Genetics of variation in HDL cholesterol in humans and mice. (semanticscholar.org)
  • suggesting either that it represents an ancient polymorphism found in the wild ancestors of laboratory mice or that a mutation occurred very early in the history of mouse domestication which then assorted itself among inbred strains. (biologists.org)
  • The DBA/2J genome is also an essential prerequisite to unbiased alignment of RNA-seq and ChIP-seq data generated using BXD strains and any other cross involving these two common parental strains. (biomedcentral.com)
  • Studies of sequence variation between inbred strains of laboratory mice suggest that the distribution of polymorphisms has a mosaic structure of alternating segments of high and low frequency ( 1 - 3 ), consistent with descent of the most commonly used strains from a few subspecies, such as Mus musculus musculus ( 4 ). (pnas.org)
  • We have identified a new, spontaneous mutation resulting in obesity and diabetes in a colony of CD-1 outbred mice, Mus musculus domesticus . (physiology.org)
  • Two hundred and fifty Mus musculus (Linnaeus, 1758) inbred mice from two animal houses in the State of Rio de Janeiro, RJ, Brazil, were divided in two groups (A, B) according to their source. (scielo.br)
  • Interestingly, CAST/EiJ mice, derived from wild Mus musculus castaneus , possess a seemingly intact Mx1 gene but are highly susceptible to influenza A virus challenge. (asm.org)
  • Here, we screened a panel of inbred strains for anxiety- and depression-related phenotypes at baseline (trait) and after exposure to repeated restraint. (jneurosci.org)
  • The first inbred strain, DBA (dilute brown agouti), was developed in 1909. (wikipedia.org)
  • V roce 1907 se začal věnovat studiu dědičnosti zbarvení srsti C. C. Little, který následně vytvořil první inbrední kmen laboratorních myší - DBA (dilute, brown, non-agouti). (avcr.cz)
  • Consequently, he created the first inbred strain of laboratory mice - DBA (dilute, brown, non-agouti). (avcr.cz)
  • Influences of inbreeding and gene. (mendeley.com)
  • a) Normal thyroid tissues from retinoblastoma gene (Rb1)+/+ (left column), Rb1D326V/+ (middle column) or Rb1+/− (right column) mice were stained with anti-E2F1 (upper section), anti-E2F2 (middle section) and anti-E2F3 (lower section) antibody using HRP chromogenic substrate, DAB (brown-colored staining). (nih.gov)
  • For virtually every mouse gene, there is a homologous human gene, and vice versa. (upenn.edu)
  • We also are using single-gene mutant mice (e.g. knockouts) to dissect pathways that mediate aggressive behaviors. (upenn.edu)
  • Five allelic mutants of the diabetes (db) gene have been previously described in mice and rats causing obesity, infertility, and varying degrees of diabetes. (physiology.org)
  • Five extant allelic mutants of the Lepr gene have been identified in inbred mice and rats ( 2 , 10 , 13 , 18 , 32 ). (physiology.org)
  • Here we report the identification and phenotypic characterization of a new spontaneous mutation of the db gene, Lepr db-NCSU , in an outbred CD-1 mouse. (physiology.org)
  • to generate 5xFAD mice homozygous for a floxed Bace1 gene ("Bace1 fl/fl/5xFAD ). (alzforum.org)
  • Amyloid plaques, reactive astrocytes and microglia, and dystrophic neurites accumulate up to day 120, but to a lesser degree than in control 5xFAD (5xFAD mice homozygous for a floxed Bace1 gene), then recede thereafter. (alzforum.org)
  • Deficit in long-term potentiation at Schaffer collateral-CA1 synapses in slices from 10- to 12-month-old mice, but less severe than that seen in slices from control mice (5xFAD mice homozygous for a floxed Bace1 gene). (alzforum.org)
  • Eye1 and Eye2: gene loci that modulate eye size, lens weight, and retinal area in the mouse. (arvojournals.org)
  • To evaluate the physiologic role of mPGES1 in the kidney, mice with targeted disruption of mPges1 gene were studied, with a focus on responses where PGE 2 has been implicated, including urinary concentration, regulation of blood pressure, and response to a loop diuretic. (asnjournals.org)
  • This may imply that mice that do not have the Ssm1b gene may use another member of the Ssm1 family to control the potentially harmful expression of certain endogenous or exogenous genes. (biologists.org)
  • First strand cDNA was synthesized and hybridized to Affymetrix GeneChip Mouse Genome 430 2.0 gene expression microarrays. (umassmed.edu)
  • The interferon-regulated Mx1 gene of the A2G mouse strain confers a high degree of resistance against influenza A and Thogoto viruses. (asm.org)
  • DBA/2J mice have a mutant Gpnmb gene and they develop a form of glaucoma preceded by a pigment dispersing iris disease and abnormalities of the immunosuppressive ocular microenvironment. (biomedcentral.com)
  • We performed quantitative trait locus/loci (QTL) analyses to identify chromosome (Chr) regions harboring genes influencing the baseline white blood cell (WBC) count, platelet (Plt) count, and mean platelet volume (MPV) in F2 intercrosses between NZW/LacJ, SM/J, and C57BLKS/J inbred mice. (semanticscholar.org)
  • We report a detailed analysis of polymorphism distribution in multiple inbred mouse strains over a 4.8-megabase region containing a QTL influencing anxiety. (pnas.org)
  • This may be discussed for two teratogens, in several inbred strains of mice, as an indication of the usefulness for elucidating some theoretic points to which it can be put. (aappublications.org)
  • We measured telomere lengths of blood leukocytes in several inbred and outbred mammalian species, using a telomere-specific fluorescent probe and flow cytometry. (mendeley.com)
  • Concentric circles represent the sequence and structural variation across mouse chromosomes. (biomedcentral.com)
  • Investigation of sequence variation in common inbred mouse strains has revealed a segmented pattern in which regions of high and low variant density are intermixed. (pnas.org)
  • We have begun to map the quantitative trait loci (QTLs) that control normal variation in the architecture of eye, lens, and retina of laboratory mice (Williams et al. (nervenet.org)
  • We had previously demonstrated interstrain variation in the phenotypic trait of serum paraxanthine/caffeine index among inbred mice. (aspetjournals.org)
  • The chromosomal regions that harbor genes that control this variation are being identified using recombinant inbred strains and intercross-backcross progeny. (nervenet.org)
  • Here, we compared robustness between cohorts of isogenic mice of eight different commonly used strains by analyzing to what extent environmental variation contributed to individuality in each of the eight genotypes, using a previously published dataset. (uva.nl)
  • In this study, I map quantitative trait loci that are responsible for variation in brain weight between mouse strains using the recombinant inbred (RI) strains, BXD and AXB/BXA, and an F 2 intercross. (nervenet.org)
  • With the recent completion of the Perlegen/NIEHS mouse resequencing [ 1 ], over ten million mouse single nucleotide polymorphisms (SNPs) are now annotated in the public databases, resulting in a dramatic increase in the genome-wide knowledge of variation among 16 of the most widely used mouse strains. (biomedcentral.com)
  • Standardized behavioral assays that measure the preference of mice for initiating social interactions with novel conspecifics would be of great value for mutant mouse models of autism. (nih.gov)
  • These findings provide insight into an interaction between two ASD candidate genes during brain development and point toward the use of compound mutant mice to validate biomarkers for ASD against biological and behavioral phenotypes. (pnas.org)
  • Earlier work also indicates that inbred strains differ in their response to stress as measured by various neural, neuroendocrine, and behavioral endpoints. (jneurosci.org)
  • For behavioral studies with laboratory mice, the subject of this paper, it is flatly impossible. (nap.edu)
  • The purpose of this presentation is to discuss some examples of the interplay between genotypes and environments, drawn from the behavioral responses of inbred strains of laboratory mice. (nap.edu)
  • Behavioral assessment of the mice: P-L Roubertoux, A. Ghata, C. Bartoli, M. Carlier. (springer.com)
  • Belichenko NP, Belichenko PV, Kleschevnikov AM, Salehi A, Reeves RH, Mobley WC (2009) The "Down syndrome critical region" is sufficient in the mouse model to confer behavioral, neurophysiological, and synaptic phenotypes characteristic of Down syndrome. (springer.com)
  • Of considerable value in this regard are isogenic inbred mouse strains. (jneurosci.org)
  • First, since the individuals of each RI strain are isogenic an infinite number of mice can be phenotyped to obtain a strain average. (nervenet.org)
  • Most QTL are mapped in F2 or back-crosses between inbred strains, a method with great power to detect small effects but with poor resolution: The 95% confidence interval often encompasses half a chromosome ( 7 ). (pnas.org)
  • As a result, mice from the Tennessee set can have the Y chromosome and mitochondrial genome from either progenitor. (jax.org)
  • In 1915, N.M Haldane identified first linkage in mouse between Albino mice and pink eye dilution on chromosome seven. (wikipedia.org)
  • Previously, in a whole genome scan, we identified quantitative trait loci (QTLs) on chromosome 10 and chromosome X that affect intermale aggressive behaviors in a cross of NZB/B1NJ and A/J inbred mice (Brodkin et al. (upenn.edu)
  • Influenza virus resistance in mice is determined largely by the Mx locus on chromosome 16, which contains two interferon (IFN)-regulated genes, designated Mx1 and Mx2 ( 1 ). (asm.org)
  • The onset of next-generation HTS enabled us to obtain full sequence coverage of a region of chromosome 1 in the D2 and B6 mouse strains. (biomedcentral.com)
  • Mark Mattson knows a lot about mice and rats. (slate.com)
  • Ad libitum feeding and lack of exercise are industry-standard for the massive rodent-breeding factories that ship out millions of lab mice and rats every year and fuel a $1.1-billion global business in living reagents for medical research. (slate.com)
  • Leptin injections accelerated reproductive maturity in WT prepubertal female mice and rats ( 5 , 7 ). (physiology.org)
  • Indeed, H 2 O 2 suppresses long-term potentiation (LTP) in hippocampal slices of normal rats and wild-type (wt) mice. (jneurosci.org)
  • More than 43 metabolites were present in the urine and faeces of mice and rats (Matuso, 1984). (inchem.org)
  • These results provide a comprehensive look at pregnanolone's discriminative stimulus effects in two commonly used strains of mice. (aspetjournals.org)
  • Thus, the present findings ratify those reported for these strains, as well as complement the evaluation of worm burden in the other commonly referred inbred mice. (scielo.br)
  • Sundberg, John 2016-04-28 00:00:00 Dystrophic cardiac calcinosis (DCC), also called epicardial and myocardial fibrosis and mineralization, has been detected in mice of a number of laboratory inbred strains, most commonly C3H/HeJ and DBA/2J. (deepdyve.com)
  • strains, most commonly C3H/HeJ and DBA/2J. (deepdyve.com)
  • As an example, we demonstrate that cryptic SNPs are prevalent, even between two of the most commonly used and well-annotated inbred mouse strains, B6 and DBA/2J (D2). (biomedcentral.com)
  • The Jackson Laboratory Mouse Genome Informatics National Cancer Institute American Association for Cancer Research Naf, Dieter (Mar 2002). (wikipedia.org)
  • A new set of BXD recombinant inbred lines from advanced intercross populations in mice. (biomedcentral.com)
  • Humans, non-human primates, and three outbred populations of Peromyscus mice ( Peromyscus leucopus, Peromyscus maniculatus, and Peromyscus polionotus) have short telomeres. (mendeley.com)
  • The metastatic potential of sub populations within mouse mammary cells is now considered as relatively an early event and dissemination occurs at the same time of pre invasive or micro-invasive lesions. (wikipedia.org)
  • We will study four well-defined and interconnected cell populations in the mouse primary visual system (photoreceptors, horizontal cells, retinal ganglion cells, and neurons in the dorsal lateral geniculate nucleus). (nervenet.org)
  • The murine model of influenza viral infection was used to evaluate the effects of restraint stress on pathogenesis and survival in the DBA/2 inbred strain of mice. (nih.gov)
  • Partial resistance has been induced in an inbred strain of mice (DBA/1) by the subcutaneous injection, and complete resistance by the intravenous injection, of suspensions of viable dbrB adenocarcinoma, a transplantable tumor indigenous to this strain. (aacrjournals.org)
  • IL-23p19 deficient mice have revealed a critical role of IL-23 in the development of experimental autoimmune diseases, such as collagen-induced arthritis (CIA). (nih.gov)
  • Breast cancer metastatic mouse models are experimental approaches in which mice are genetically manipulated to develop a mammary tumor leading to distant focal lesions of mammary epithelium created by metastasis. (wikipedia.org)
  • These studies found that T H 1 cells were not required for induction of experimental autoimmune encephalomyelitis (EAE) in mice, as had been thought [ 4 , 5 ]. (hindawi.com)
  • This approach intends to add new data on the helminth parasites of laboratory mice, since these investigations have arised a great interest and also, taking into account that these hosts as experimental animal models, are widely utilized in the evaluation of several biological parameters. (scielo.br)
  • Nevertheless, the history of using experimental mice goes back even further. (avcr.cz)
  • One means of gaining a better understanding of glaucoma pathogenesis, and ultimately the creation of new therapeutic interventions, is to study the underlying molecular pathways with experimental systems such as the mouse. (biomedcentral.com)
  • There are close similarities of physiology, development and cell biology between mice and humans. (wikipedia.org)
  • We generated approximately 13.2 and 38.9× whole-genome short reads of DBA/2J females using Illumina GA2 and ABI SOLiD massively parallel DNA sequencing platforms. (biomedcentral.com)
  • Initial sequencing and comparative analysis of the mouse genome. (biomedcentral.com)
  • The apparent mosaic structure of the mouse genome can be exploited for QTL mapping in two ways. (pnas.org)
  • MMHCdb is part of the Mouse Genome Informatics consortium (MGI) and was first released in 1998 as the Mouse Tumor Biology (MTB) database. (wikipedia.org)
  • Molecular biology and genome editing technologies transformed the use of mice in cancer research by allowing researchers to develop animal models with specific mutations or that expressed human genes (transgenics). (wikipedia.org)
  • F2 mice exposed to 2.0 mg Hg were genotyped with microsatellites for genome-wide scan with Ion Pair Reverse Phase High Performance Liquid Chromatography (IP RP HPLC). (diva-portal.org)
  • In the present study, we have undertaken a genome-wide scan for quantitative trait loci affecting this trait with an interval mapping approach on an F 2 intercross population of acetaminophen nonsusceptible and C3H/HeJ inbred mice. (aspetjournals.org)
  • In a genome wide screen of genes expressed in the mouse retina, we found aged DBA2/J retinas from 12 to 17 month old mice with glaucomatous loss of RGC have significantly decreased levels of gamma-synuclein expression that correlate with age and severity of RGC loss. (umassmed.edu)
  • These B6D2F1 mice are heterozygous for all B6 and D2 specific alleles across the entirety of the autosomal genome. (biomedcentral.com)
  • Our analysis indicates that it is only partly true that the genomes of inbred strains exist as a patchwork of segments of sequence identity and difference. (pnas.org)
  • 90% of the human and mouse genomes are syntenic. (wikipedia.org)
  • 40% of both human and mouse genomes can be aligned at the nucleotide level. (wikipedia.org)
  • C5 -deficient B10.D2 mice were protected from CM, whereas C5 -sufficient B10.D2 mice were susceptible. (rupress.org)
  • Antibody blockade of C5a or C5a receptor (C5aR) rescued susceptible mice from CM. In vitro studies showed that C5a-potentiated cytokine secretion induced by the malaria product P. falciparum glycosylphosphatidylinositol and C5aR blockade abrogated these amplified responses. (rupress.org)
  • Conversely, A/J mice, although equally susceptible to PbA infection, are more resistant to the associated CM syndrome ( 6 - 7 ). (rupress.org)
  • Our data show that virus-infected B6.S mice are free from disease and have significantly lower viral loads than susceptible SJL mice, particularly in the spinal cord. (asm.org)
  • Intracerebral infection of susceptible mice with Theiler's murine encephalomyelitis virus (TMEV) induces an immune-mediated, progressive inflammatory demyelinating disease (IDD) that is similar to a progressive form of human multiple sclerosis (MS) ( 1 , 2 ). (asm.org)
  • Performance of mice in motor function tests for ethanol sensitivity is often task dependent, not reflective of coordinated movement, and reported qualitatively. (nih.gov)
  • AFT calculated as a difference between the maximum BEC at any recovery and the value of initial sensitivity was greater in DBA/2J mice. (mendeley.com)
  • Pentobarbital and midazolam were more potent in producing pregnanolone-like discriminative stimulus effects in DBA/2J mice. (aspetjournals.org)
  • Outline drawings of cortical map phenotypes in wild type mice and mice over expressing Emx2 show changes in the shape of PMBSF and V1. (beds.ac.uk)
  • The DBA/2J mouse is not only the oldest inbred strain, but also one of the most widely used strains. (biomedcentral.com)
  • Xenobiotic metabolizing enzymes (XME) are expressed at higher levels in calorically restricted mice (CR) and in GH/IGF-I-deficient, long-lived mutant mice. (isharonline.org)
  • Because inactivation of the functions of E2F was considered to be the major mechanism by which pRb suppressed tumor development, we focused on the E2F proteins in the mutant mice. (nih.gov)
  • For this purpose, we performed IHC to evaluate the level of E2F and found that E2F1, E2F2 and E2F3 were decreased in the thyroid C-cells of the mutant Rb1+/− mice (Fig.3a). (nih.gov)
  • Mutant mice drank up to four times more water and were up to two times heavier than wild-type mice. (physiology.org)
  • and mutant human PSEN1 including the M146L and L286V mutations driven by the mouse Thy1 promoter. (alzforum.org)
  • We wish to express our gratitude to the European Mouse Mutant Archive (EMMA) for the generous gift of two strains of segmental trisomic mice. (springer.com)
  • Furthermore, it has been suggested that allelic strain distribution patterns also occur in well defined blocks and consequently could be used to map quantitative trait loci (QTL) in comparisons between inbred strains. (pnas.org)
  • Quantitative trait loci that determine lipoprotein cholesterol levels in DBA/2J and CAST/Ei inbred mice. (semanticscholar.org)
  • This research focuses on four discrete neuron types in the mouse CNS that are amenable to accurate and economical quantitative analysis: retinal ganglion cells (large projection neurons), photoreceptors, horizontal cells (smaller interneurons), and neurons in the dorsal lateral geniculate nucleus. (nervenet.org)
  • Quantitative trait loci (QTLs) will be mapped using both recombinant inbred strains and the maximum likelihood interval method of Lander and Botstein (1989) on intercross progeny. (nervenet.org)
  • Our study generates the first consensus sequence for the DBA/2J and creates a compendium of sequence and structural variations that will be used by the community of researchers who study complex traits in mouse models. (biomedcentral.com)
  • Because our study utilizes a genetically diverse population of mice with known sequence variants, we are able to determine that the intraocular pressure-lowering effect of pregabalin is dependent on the Cacna2d1 haplotype. (nature.com)
  • B6 mice always showed an alternate step sequence, whereas D2 mice sometimes showed cruciate and rotary step sequences. (nih.gov)
  • We identified in DBA/1 (I-A q ) mice six immunodominant T cell determinants in the MalE sequence, 89-95, 116-123, 198-205, 211-219, 274-281, and 335-341. (jimmunol.org)
  • METHODS: Arthritis was induced in DBA/1J mice by subcutaneous immunization with bovine type II collagen on days 0 and 21. (isharonline.org)
  • To profile the kinetics of Th1 and Th17 cells during collagen-induced arthritis (CIA), splenocytes were isolated from type II collagen (CII)-immunized DBA/1 mice at various time points post-immunization (p.i.) and assessed for intracellular cytokines by flow cytometry. (nih.gov)
  • However, sampling has so far been carried out at a low density: Wiltshire and colleagues ( 3 ) sequenced 2,600 evenly distributed loci at intervals of ≈1.1 megabases (Mb) in eight inbred strains. (pnas.org)
  • We concluded that inbreeding, through unknown mechanisms, results in the elongation of telomeres, and that telomere length for a given species and/or sub-strain is genetically determined by multiple segregating loci. (mendeley.com)
  • The role of C5 was further explored in B10.D2 mice, which are identical for all loci other than C5 . (rupress.org)
  • Three mammalian species are reservoir competent: the white-footed mouse ( Peromyscus leucopus ), raccoon ( Procyon lotor ), and gray squirrel ( Sciurus carolinensis ), although serologic and molecular evidence has suggested that numerous other small, medium, and large mammals may also be reservoirs ( 1 , 3 ). (cdc.gov)
  • Thus, our data provide important clues to the molecular mechanisms underlying cryodamage to mouse spermatozoa. (go.jp)
  • Co-opting endogenous immunoglobulin for the regulation of inflammation and osteoclastogenesis in humans and mice. (biomedsearch.com)
  • Humans and mice both have around 30,000 protein-coding genes. (wikipedia.org)
  • Cell types in the brains of mice and humans are almost indistinguishable in structure and function, but their numbers vary over more than three orders of magnitude. (nervenet.org)
  • A total of 10 mice were tested from each strain (5 males, 5 females) for KCl, CYX, PROP, MgCl 2 and QHCl. (biomedcentral.com)
  • A total of 11 B6 mice (6 females, 5 males) and 9 D2 mice (5 females, 4 males) were tested with RUA. (biomedcentral.com)
  • One of the major advantages of the BXDs relative to the Collaborative Cross and other new resources is that the DBA/2J progenitor strain and many of the BXD progeny strains consistently develop high IOP between 6 and 10 months of age 31 . (nature.com)
  • For example, Krubitzer and Kahn [ 1 ] review that the mouse, ghost bat, and short-tailed opossum have approximately the same size cortical sheet, but differ substantially in the size of one of three primary sensory cortical areas. (beds.ac.uk)
  • The total population of single cell types differ as much as twofold between inbred strains of mice. (nervenet.org)
  • Sperm function, protein phosphorylation and metabolism differ in mice lacking successive sperm-specific glycolytic enzymes. (hamiltonthorne.com)
  • Because of the small number of patients with partial trisomy 21, we addressed the question in the Mouse in which three chromosomal regions located on MMU10, MMU17 and MMU16 carries almost all the HSA21 homologs. (springer.com)
  • All the BXD mice were obtained directly from the Jackson Laboratory (Bar Harbor, ME). (nervenet.org)
  • But only the targeted production of various inbred lab mice at the Jackson Laboratory at Bar Harbor resulted in large-scale use of mice as a suitable model laboratory organism. (avcr.cz)
  • Acute maternal deprivation of riboflavin at the end of the middle-third of pregnancy of inbred mice has thus been shown to induce a great many malformations in the offspring. (aappublications.org)
  • Nonetheless, urinary osmolalities were similar in mPges1 +/+ and mPges1 −/− mice at baseline and after 12 h of water deprivation. (asnjournals.org)
  • Developmental studies of inbred and recombinant inbred strains are being carried out in parallel to determine whether these genes control rates of neuron production or rates of survival. (nervenet.org)
  • Yamada M, Egli D. Developmental Potential of Developmentally Compromised Postovulatory Aged Mouse Oocytes. (hamiltonthorne.com)
  • Amri A, Abdullah R, Embong W. Developmental Potential of Mouse Single Blastomere Derived from Isolated 2-, 4- and 8- Cell Embryos into Blastocyst and Inner Cell Mass (ICM) Outgrowths. (hamiltonthorne.com)
  • Dietary BHT did not result in an increased incidence of lung tumours in either male or female C 3 H mice. (inchem.org)
  • 2013. Use of the expanded panel of BXD mice narrow QTL regions in ethanol-induced locomotor activation and motor incoordination. (jax.org)
  • As a proportion of the total cortical sheet, the area of V1 was 52% increased and the area of PMBSF was 25% decreased in ne-Emx2 mice compared to wild-type mice [ 5 ]. (beds.ac.uk)
  • The furosemide-induced increase in urinary PGE 2 excretion that was seen in wild-type mice was attenuated in mPGES1-deficient mice. (asnjournals.org)
  • Expression of agouti-related peptide (AGRP) in the hypothalamus is increased in NPY knockout (NPYko) than wild-type mice, but unlike wild type there is no further increase in AGRP when NPYko mice are fasted. (diabetesjournals.org)
  • 5XFAD mice carry APP (with the Swedish, Florida, and London mutations) and PSEN1 (with M146L and L286V mutations) transgenes. (alzforum.org)

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