Animals, Outbred Strains
Species Specificity
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
Effect of sex difference on the in vitro and in vivo metabolism of aflatoxin B1 by the rat. (1/92290)
Hepatic microsome-catalyzed metabolism of aflatoxin B1 (AFB1) to aflatoxin M1 and aflatoxin Q1 and the "metabolic activation" of AFB1 to DNA-alylating metabolite(s) were studied in normal male and female Sprague-Dawley rats, in gonadectomized animals, and in castrated males and normal females treated with testosterone. Microsomes from male animals formed 2 to 5 times more aflatoxin M1, aflatoxin Q1, and DNA-alkylating metabolite(s) than those from females. Castration reduced the metabolism of AFB1 by the microsomes from males by about 50%, whereas ovariectomy had no significant effect on AFB1 metabolism by the microsomes from females. Testosterone treatment (4 mg/rat, 3 times/week for about 6 weeks) of castrated immature males and immature females enhanced the metabolism of AFB1 by their microsomes. A sex difference in the metabolism of AFB1 by liver microsomes was also seen in other strains of rats tested: Wistar, Long-Evans, and Fischer. The activity of kidney microsomes for metabolic activation was 1 to 4% that of the liver activity and was generally lower in microsomes from male rats as compared to those from female rats of Sprague-Dawley, Wistar, and Long-Evans strains. The in vitro results obtained with hepatic microsomes correlated well with the in vivo metabolism of AFB1, in that more AFB1 became bound in vivo to hepatic DNA isolated from male rats and from a female rat treated with testosterone than that isolated from control female rats. These data suggest that the differences in hepatic AFB1 metabolism may be the underlying cause of the sex difference in toxicity and carcinogenicity of AFB1 observed in rats. (+info)Tissue pharmacokinetics, inhibition of DNA synthesis and tumor cell kill after high-dose methotrexate in murine tumor models. (2/92290)
In Sarcoma 180 and L1210 ascites tumor models, the initial rate of methotrexate accumulation in tumor cells in the peritoneal cavity and in small intestine (intracellularly) after s.c. doses up to 800 mg/kg, showed saturation kinetics. These results and the fact that initial uptake in these tissues within this dosage range was inhibited to the expected relative extent by the simultaneous administration of leucovorin suggest that carrier mediation and not passive diffusion is the major route of drug entry at these extremely high doses. Maximum accumulation of intracellular drug occurred within 2 hr and reached much higher levels in small intestine than in tumor cells at the higher dosages. At a 3-mg/kg dose of methotrexate s.c., intracellular exchangeable drug levels persisted more than four times longer in L1210 cells than in small intestine, but differences in persistence (L1210 cell versus gut) diminished markedly with increasing dosage. At 96 mg/kg, the difference in persistence was less than 2-fold. In small intestine and L1210 cells, theduration of inhibition of DNA synthesis at different dosages correlated with the extent to which exchangeable drug was retained. Toxic deaths occurred when inhibition in small intestine lasted longer than 25 to 30 hr. Recovery of synthesis in small intestine and L1210 cells occurred synchronously and only below dosages of 400 mg/kg. Within 24 hr after dosages of greater than 24 mg/kg, the rate of tumor cell loss increased to a point characterized by a single exponential (t1/2=8.5 hr). The total cell loss, but not the rate of cell loss, was dose dependent. (+info)Explanations for the clinical and microscopic localization of lesions in pemphigus foliaceus and vulgaris. (3/92290)
Patients with pemphigus foliaceus (PF) have blisters on skin, but not mucous membranes, whereas patients with pemphigus vulgaris (PV) develop blisters on mucous membranes and/or skin. PF and PV blisters are due to loss of keratinocyte cell-cell adhesion in the superficial and deep epidermis, respectively. PF autoantibodies are directed against desmoglein (Dsg) 1; PV autoantibodies bind Dsg3 or both Dsg3 and Dsg1. In this study, we test the hypothesis that coexpression of Dsg1 and Dsg3 in keratinocytes protects against pathology due to antibody-induced dysfunction of either one alone. Using passive transfer of pemphigus IgG to normal and DSG3(null) neonatal mice, we show that in the areas of epidermis and mucous membrane that coexpress Dsg1 and Dsg3, antibodies against either desmoglein alone do not cause spontaneous blisters, but antibodies against both do. In areas (such as superficial epidermis of normal mice) where Dsg1 without Dsg3 is expressed, anti-Dsg1 antibodies alone can cause blisters. Thus, the anti-desmoglein antibody profiles in pemphigus sera and the normal tissue distributions of Dsg1 and Dsg3 determine the sites of blister formation. These studies suggest that pemphigus autoantibodies inhibit the adhesive function of desmoglein proteins, and demonstrate that either Dsg1 or Dsg3 alone is sufficient to maintain keratinocyte adhesion. (+info)Bone resorption induced by parathyroid hormone is strikingly diminished in collagenase-resistant mutant mice. (4/92290)
Parathyroid hormone (PTH) stimulates bone resorption by acting directly on osteoblasts/stromal cells and then indirectly to increase differentiation and function of osteoclasts. PTH acting on osteoblasts/stromal cells increases collagenase gene transcription and synthesis. To assess the role of collagenase in the bone resorptive actions of PTH, we used mice homozygous (r/r) for a targeted mutation (r) in Col1a1 that are resistant to collagenase cleavage of type I collagen. Human PTH(1-34) was injected subcutaneously over the hemicalvariae in wild-type (+/+) or r/r mice four times daily for three days. Osteoclast numbers, the size of the bone marrow spaces and periosteal proliferation were increased in calvariae from PTH-treated +/+ mice, whereas in r/r mice, PTH-induced bone resorption responses were minimal. The r/r mice were not resistant to other skeletal effects of PTH because abundant interstitial collagenase mRNA was detected in the calvarial periosteum of PTH-treated, but not vehicle-treated, r/r and +/+ mice. Calcemic responses, 0.5-10 hours after intraperitoneal injection of PTH, were blunted in r/r mice versus +/+ mice. Thus, collagenase cleavage of type I collagen is necessary for PTH induction of osteoclastic bone resorption. (+info)GM-CSF-deficient mice are susceptible to pulmonary group B streptococcal infection. (5/92290)
Granulocyte-macrophage colony-stimulating factor (GM-CSF) gene-targeted mice (GM-/-) cleared group B streptococcus (GBS) from the lungs more slowly than wild-type mice. Expression of GM-CSF in the respiratory epithelium of GM-/- mice improved bacterial clearance to levels greater than that in wild-type GM+/+ mice. Acute aerosolization of GM-CSF to GM+/+ mice significantly enhanced clearance of GBS at 24 hours. GBS infection was associated with increased neutrophilic infiltration in lungs of GM-/- mice, while macrophage infiltrates predominated in wild-type mice, suggesting an abnormality in macrophage clearance of bacteria in the absence of GM-CSF. While phagocytosis of GBS was unaltered, production of superoxide radicals and hydrogen peroxide was markedly deficient in macrophages from GM-/- mice. Lipid peroxidation, assessed by measuring the isoprostane 8-iso-PGF2alpha, was decreased in the lungs of GM-/- mice. GM-CSF plays an important role in GBS clearance in vivo, mediated in part by its role in enhancing superoxide and hydrogen peroxide production and bacterial killing by alveolar macrophages. (+info)A new element within the T-cell receptor alpha locus required for tissue-specific locus control region activity. (6/92290)
Locus control regions (LCRs) are cis-acting regulatory elements thought to provide a tissue-specific open chromatin domain for genes to which they are linked. The gene for T-cell receptor alpha chain (TCRalpha) is exclusively expressed in T cells, and the chromatin at its locus displays differentially open configurations in expressing and nonexpressing tissues. Mouse TCRalpha exists in a complex locus containing three differentially regulated genes. We previously described an LCR in this locus that confers T-lineage-specific expression upon linked transgenes. The 3' portion of this LCR contains an unrestricted chromatin opening activity while the 5' portion contains elements restricting this activity to T cells. This tissue-specificity region contains four known DNase I hypersensitive sites, two located near transcriptional silencers, one at the TCRalpha enhancer, and another located 3' of the enhancer in a 1-kb region of unknown function. Analysis of this region using transgenic mice reveals that the silencer regions contribute negligibly to LCR activity. While the enhancer is required for complete LCR function, its removal has surprisingly little effect on chromatin structure or expression outside the thymus. Rather, the region 3' of the enhancer appears responsible for the tissue-differential chromatin configurations observed at the TCRalpha locus. This region, herein termed the "HS1' element," also increases lymphoid transgene expression while suppressing ectopic transgene activity. Thus, this previously undescribed element is an integral part of the TCRalphaLCR, which influences tissue-specific chromatin structure and gene expression. (+info)Prolonged eosinophil accumulation in allergic lung interstitium of ICAM-2 deficient mice results in extended hyperresponsiveness. (7/92290)
ICAM-2-deficient mice exhibit prolonged accumulation of eosinophils in lung interstitium concomitant with a delayed increase in eosinophil numbers in the airway lumen during the development of allergic lung inflammation. The ICAM-2-dependent increased and prolonged accumulation of eosinophils in lung interstitium results in prolonged, heightened airway hyperresponsiveness. These findings reveal an essential role for ICAM-2 in the development of the inflammatory and respiratory components of allergic lung disease. This phenotype is caused by the lack of ICAM-2 expression on non-hematopoietic cells. ICAM-2 deficiency on endothelial cells causes reduced eosinophil transmigration in vitro. ICAM-2 is not essential for lymphocyte homing or the development of leukocytes, with the exception of megakaryocyte progenitors, which are significantly reduced. (+info)Phenotype of mice and macrophages deficient in both phagocyte oxidase and inducible nitric oxide synthase. (8/92290)
The two genetically established antimicrobial mechanisms of macrophages are production of reactive oxygen intermediates by phagocyte oxidase (phox) and reactive nitrogen intermediates by inducible nitric oxide synthase (NOS2). Mice doubly deficient in both enzymes (gp91(phox-/-)/NOS2(-/-)) formed massive abscesses containing commensal organisms, mostly enteric bacteria, even when reared under specific pathogen-free conditions with antibiotics. Neither parental strain showed such infections. Thus, phox and NOS2 appear to compensate for each other's deficiency in providing resistance to indigenous bacteria, and no other pathway does so fully. Macrophages from gp91(phox-/-)/NOS2(-/-) mice could not kill virulent Listeria. Their killing of S. typhimurium, E. coli, and attenuated Listeria was markedly diminished but demonstrable, establishing the existence of a mechanism of macrophage antibacterial activity independent of phox and NOS2. (+info)
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Malignant transformation in vitro of cells from c57bl mouse normal pul by G Barski and R Cassingena
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Anti-CD25 antibody-mediated depletion of effector T cell populations enhances susceptibility of mice to acute but not chronic...
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Antigen-loaded monocyte administration induces potent therapeutic antitumor T cell responses
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Individual differences in the antibody response of inbred C57Bl/6J mice and their relation to individual differences in open...
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Sequence Detail
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Exam 2 Flashcards
Laboratory mouse
... inbred mouse strain and initiated the systematic generation of inbred strains. The mouse has since been used extensively as a ... were C57BL/6 laboratory mice. Sequencing of the laboratory mouse genome was completed in late 2002 using the C57BL/6 strain. ... "Dirty" mice are possibly better suitable for mimicking human pathologies. In addition, inbred mouse strains are used in the ... "BALB/c". Inbred Strains of Mice. Jackson Laboratory. Retrieved 2007-04-16. "BALB/cByJ". Jax Mice Data Sheet. Jackson Laboratory ...
William J. Schwartz
Schwartz WJ, Zimmerman P. Circadian timekeeping in BALB/c and C57BL/6 inbred mouse strains. J Neurosci. 1990; 10: 3685-3694. ...
Coisogenic strain
C57BL/6J) mouse. The offspring of the mutated mouse with the inbred strain has a 50% chance of carrying the mutation. From this ... To create a coisogenic strain through breeding, a mouse with the specific mutation on a locus is mated to an inbred strain (e.g ... There are numerous ways to create an inbred strain and each of these strains are unique. Genetically engineered mice can be ... Bult, CJ; Eppig, JT; Blake, JA; Kadin, JA; Richardson, JE; Mouse Genome Database, Group (4 January 2016). "Mouse genome ...
Pregnanolone (disambiguation)
... of the Discriminative Stimulus Effects of the Neuroactive Steroid Pregnanolone in DBA/2J and C57BL/6J Inbred Mice". Journal of ...
Major urinary proteins
Some inbred laboratory mouse strains, such as BALB/c and C57BL/6, also have different proteins expressed in their urine. ... using white-footed mice, it was found that when mice derived from wild populations were inbred, there was reduced survival when ... Wild mice breeding freely in semi-natural enclosures showed inbreeding avoidance. This avoidance resulted from a strong deficit ... These findings suggest that inbreeding reduces fitness, and that scent signal recognition has evolved in mice as a means of ...
C. C. Little
In 1921, he inbred the mouse strain C57BL/6 or "black 6", which is the most popular laboratory mouse to date. His most ... C. C. Little, Cancer and Inbred Mice by James F. Crow, "Genetics", Vol. 161, 1357-1361, August 2002. Clarence Cook Little (1888 ... The lab was quickly rebuilt and most mouse strains were recovered from other labs around the world. By 1950, the lab was ... Little energetically developed both the lab and the ACS, and by 1944 they were shipping 9000 mice a week to other laboratories ...
MA-10 cell
The cell line is a luteinizing hormone-dependent steroidogenic cell line that was generated from a mice inbred strain C57BL/6J ... MA-10 cells are a model cell line derived from the mouse Leydig cell tumor used in biomedical research. ...
Mouse models of breast cancer metastasis
N.M Haldane identified first linkage in mouse between Albino mice and pink eye dilution on chromosome seven. In 1921, C57BL ... In 1909, Clarence C. Little developed the first inbred strain, the DBA (Dilute, brown non-Agouti) mouse. In 1915, ... Mice have relatively short gestation periods. Mice take a brief time to reach sexual maturity. Mice have large litter sizes. ... The number of mouse genes without a corresponding human homologue is less than 1%. 90% of the human and mouse genomes are ...
Murine respirovirus
C57BL/6 mice are highly resistant to the virus, while DBA/2J mice are sensitive. C57BL/6 mice showed slight loss of body weight ... Parker JC, Whiteman MD, Richter CB (January 1978). "Susceptibility of inbred and outbred mouse strains to Sendai virus and ... It was suggested that the mice used to passage the virus were infected with the mouse virus. Thus, mouse virus was later ... Only 10% mortality rate was observed in C57BL/6 mice after the administration of very high virulent dose of 1*105 TCID50. It ...
Abbie Lathrop
He trained C. C. Little who bred C57BL/6J ("Black 6") from Lathrop's mouse number 57. Black 6 became the most frequently used ... Abbie E. C. Lathrop (1868 - 1918) was a rodent fancier who bred fancy mice and inbred strains for animal models, particularly ... She bred Japanese waltzing mice as well as fancy mice. The mice had straw bedding and lived in wooden boxes. They were fed a ... Lathrop started out with a pair of waltzing mice she obtained in Granby and her farm grew to hold over 11,000 mice at one point ...
Diet-induced obesity model
"Differential effect of inbred mouse strain (C57BL/6, DBA/2, 129T2) on insulin secretory function in response to a high fat diet ... In the strain of mice most commonly used for DIO models, C57BL/6J, mice who started the diet at 10 weeks old showed lower ... For example, mice were put on a high-fat diet, but given either tap water, green tea, or Goishi tea to drink. The mice who ... West, D. B.; Boozer, C. N.; Moody, D. L.; Atkinson, R. L. (1992-06-01). "Dietary obesity in nine inbred mouse strains". The ...
Jeffrey Mogil
"Genetic sensitivity to hot-plate nociception in DBA/2J and C57BL/6J inbred mouse strains: possible sex-specific mediation by δ2 ... female mice are more sensitive to itch than male mice; pain reduces sexual desire in male but not female mice; sex differences ... They showed that mice display more pain behavior if they are tested in close proximity to other mice also in pain, but only if ... In 1999, they showed that different inbred strains of mice displayed very different pain sensitivity. Chief among these ...
Inbred strain
C57BL, C57BR and C57L). Many of the most popular strains of mice were developed during the next decade, and some are closely ... and only three un-pedigreed mice remained alive. Soon after World War I, inbreeding in mice was started on a much larger scale ... A/J C3H C57BL/6 CBA DBA/2 BALB/c G. M. Rommel first started conducting inbreeding experiments on guinea pigs in 1906. Strain 2 ... "The period before World War I led to the initiation of inbreeding in rats by Dr Helen King in about 1909 and in mice by Dr C. C ...
C57
... a barred irregular galaxy C57BL/6, a common inbred strain of lab mouse Fried Liver Attack, a chess opening HMS Cumberland (C57 ...
List of MeSH codes (B01)
... mice, inbred balb c MeSH B01.050.157.520.388 - mice, inbred c3h MeSH B01.050.157.520.420 - mice, inbred c57bl MeSH B01.050. ... mice, inbred balb c MeSH B01.050.199.520.520.388 - mice, inbred c3h MeSH B01.050.199.520.520.420 - mice, inbred c57bl MeSH ... mice, inbred cba MeSH B01.050.157.520.445 - mice, inbred cftr MeSH B01.050.157.520.460 - mice, inbred dba MeSH B01.050.157.520. ... 480 - mice, inbred hrs MeSH B01.050.157.520.510 - mice, inbred icr MeSH B01.050.157.520.555 - mice, inbred mrl lpr MeSH B01.050 ...
B6
... a subgroup of the Anatomical Therapeutic Chemical Classification System C57BL/6, an inbred mouse strain B6 (musician), a ...
Jan Klein
... be alleviated by transferring a sample of H2 haplotypes from wild mice onto inbred (C57BL/10 or B10) background and thus ... Typing of inbred strains suggested that the Mhc might manifest unusually high variability (polymorphism). Inbred strains were, ... The karyotype of the house mouse normally consists of 40 telocentric chromosomes, but in certain regions in Europe, mice with ... Genetic mapping of the loci controlling the class I and class II antigens of the mouse showed them to be part of a cluster, ...
Recombinant inbred strain
... and a male C57BL/6By mouse in the 1960s. The small panel of 8 CXB strains was originally used to determine if the Major ... Recombinant inbred strains or lines were first developed using inbred strains of mice but are now used to study a wide range of ... pairs of the F2 progeny are then mated to establish inbred strains through long-term inbreeding. Families of recombinant inbred ... In the case of a typical mouse recombinant inbred strain made by crossing maternal strain BALB/cBy (C) with paternal strain ...
Japanese house mouse
It has genetic similarity to C57BL/6N, and generally differs from other inbred stains. It has been used as a model in the study ... It is among the smallest house mice. Different strains such as MSM/Ms, JF1, Japanese waltzing mouse, C57BL/6J and MSKR exist ... The Japanese house mouse or Japanese wild mouse (Mus musculus molossinus) is a type of house mouse that originated in Japan. ... fancy mouse) in the 19th century. This black coloured mouse is a sub-strain of C57BL/6 created in 1921 by C. C. Little at the ...
Justin Rhodes
Rhodes, JS; Ford, MM; Yu, CH; Brown, LL; Finn, DA; Garland Jr, T; Crabbe, JC (2007). "Mouse inbred strain differences in ... "Acute effects of acamprosate and MPEP on ethanol Drinking-in-the-Dark in male C57BL/6J mice". Alcoholism: Clinical and ... Rhodes was one of the developers of the Drinking in the Dark model in mice. In this model, a specific mouse strain is found to ... "Acute effects of naltrexone and GBR 12909 on ethanol drinking-in-the-dark in C57BL/6J mice". Psychopharmacology. 192 (2): 207- ...
Mouse Models of Human Cancer database
Among the earliest references to the use of inbred mice in cancer was the observed susceptibility of the A family of inbred ... For example, transgenic mice on a mixed C57BL/6J and SJL background expressing human HRAS have a mammary gland carcinoma ... MMHCdb contains genetic and genomic information about inbred mouse strains, genetically engineered mouse models (GEMMs) and ... Inbred mouse strains are the result of at least 20 generations of successive brother/sister matings which lead to a population ...
NOG mouse
The NOG mouse was generated in CIEA in 2000 by back-cross mating of C57BL/6J-IL-2Rγnull mouse that was originally developed by ... The NOD/Shi inbred strain was first discovered by Makino et al. as autoimmune non-obese-type diabetes mice. Lack of functional ... Cancer Infectious Diseases Regenerative Medicine Hematology Humanized mouse Nude mouse SCID mouse M. Ito and, et al. (2002). " ... such as nude mouse and NOD/scid mouse. Thus, the mouse can be the best model as a highly efficient recipient of human cells to ...
Helicobacter bilis
nov., a novel Helicobacter species isolated from bile, livers, and intestines of aged, inbred mice". Journal of Clinical ... "Concurrent Helicobacter bilis Infection in C57BL/6 Mice Attenuates Proinflammatory H. pylori-Induced Gastric Pathology". ... 2000]. H. rappini has also been isolated from the feces of healthy people, dogs, and mice, as well as from patients with ... Like Helicobacter hepaticus, it colonizes the bile, liver, and intestine of mice, and is associated with multifocal chronic ...
Animal testing on rodents
"Dirty" mice are possibly better suitable for mimicking human pathologies. In addition, inbred mouse strains are used in the ... Animal testing Animal model BALB/c C57BL/6 Fe, Fi, Fo, Fum, and Phooey, five mice who orbited the Moon in 1972 Mouse models of ... Mice differ from humans in several immune properties: mice are more resistant to some toxins than humans; have a lower total ... Thirty to fifty live mice are normally born from this number of injected blastocysts. Normally, the skin color of the mice from ...
National Institute of Nutrition, Hyderabad
... and Leads to Adverse Gestational Outcome in Female C57BL/6 Mice". Frontiers in Nutrition. 3 (1): 1-10. doi:10.3389/fnut. ... NCLAS also came into the limelight due to the WNIN/Ob obese rat strain which is the heaviest inbred rat model available. It has ... "Mice to reveal key to human obesity". The Times of India. Archived from the original on 16 June 2013. "Australia-India food ...
History of model organisms
The idea of inbreeding to achieve this goal of a 'pure strain' in mice was one that may have created a negative response to the ... C57BL/6 (lab mice), etc. These organisms have led to many advances in the past century. Some of the first work with what would ... 30-35 Rader, Making Mice Rader, Making Mice, pp. 190-195 Rader, Making Mice, p. 252 Allen, Garland E. Thomas Hunt Morgan: The ... He would continue his work with these mice and used his research to demonstrate that inbreeding is an effective way of ...
Natural killer cell
Smith HJ (December 1966). "Antigenicity of carcinogen-induced and spontaneous tumours in inbred mice". British Journal of ... NK1.1 or NK1.2 in C57BL/6 mice. The NKp46 cell surface marker constitutes, at the moment, another NK cell marker of preference ... in the mouse, and by Hugh Pross and doctoral student Mikael Jondal in the human. The mouse and human work was carried out under ... In both mice and humans, NKs can be seen to play a role in tumor immunosurveillance by directly inducing the death of tumor ...
Differential effect of inbred mouse strain (C57BL/6, DBA/2, 129T2) on insulin secretory function in response to a high fat diet
C57BL/6, DBA/2, 129T2) on insulin secretory function in response to a high fat diet ... animalsargininebreedingdietary fatsfastingglucoseinsulinislets of langerhansmiceinbred miceC57BLspecies specificityScience & ... DBA/2 mice hypersecreted insulin in response to glucose and glucose plus arginine compared with C57BL/6 and 129T2 mice. ... mice had higher fasting plasma glucose levels and lower fasting plasma insulin levels compared with C57BL/6 and DBA/2 mice ...
A specific antidote for reversal of anticoagulation by direct and indirect inhibitors of coagulation factor Xa
Genetics, ethanol and the Fos response: A comparison of the C57BL/6J and DNA/2J inbred mouse strains<...
Genetics, ethanol and the Fos response: A comparison of the C57BL/6J and DNA/2J inbred mouse strains. Alcoholism: Clinical and ... Hitzemann, B & Hitzemann, R 1997, Genetics, ethanol and the Fos response: A comparison of the C57BL/6J and DNA/2J inbred mouse ... Dive into the research topics of Genetics, ethanol and the Fos response: A comparison of the C57BL/6J and DNA/2J inbred mouse ... Genetics, ethanol and the Fos response : A comparison of the C57BL/6J and DNA/2J inbred mouse strains. / Hitzemann, Barbara; ...
IMSEAR at SEARO: Genetic analysis of the mandible morphology in DDD.Cg-Ay/Sgn and C57BL/6J inbred mice
Genetic analysis of the mandible morphology in DDD.Cg-Ay/Sgn and C57BL/6J inbred mice. Journal of Genetics. 2019 Aug; 98: 1-14 ... Genetic analysis of the mandible morphology in DDD.Cg-Ay/Sgn and C57BL/6J inbred mice. ... mapping analysis was performed for the mandible morphology in DDD.Cg-Ay/Sgn and C57BL/6J inbred mice. The size and shape of the ... These QTLs explained 46.85% of the centroid size variation in F2 mice. When the F2Ay and F2 non-Ay mice were analysed ...
Circuit properties generating gamma oscillations in a network model of the olfactory bulb
Deletion in chromosome 6 spanning alpha-synuclein and multimerin1 loci in the Rab27a/b double knockout mouse | Scientific...
... the Rab27a/b DKO mouse line should be used with caution or with appropriate back-crossing to other C57BL/6J mouse substrain ... Western blot and RT-PCR studies revealed lack of αsyn expression at either the mRNA or protein level in Rab27a/b DKO mice. PCR ... Electron microscopy of cortex from these mice demonstrates abnormally enlarged synaptic terminals with reduced synaptic vesicle ... a slightly smaller deletion region than that previously reported in the C57BL/6J substrain maintained by Envigo. ...
MPD: Mouse strain: C57BL/6JOlaHsd
Biblio | Page 3 | Linus Pauling Institute | Oregon State University
Mice, Inbred C57BL. Bella DL, Schock BC, Lim Y, Leonard SW, Berry C, Cross CE, Traber MG. 2006. Regulation of the alpha- ... Mice. Lim Y, Schock BC, Gohil K, Leonard SW, Packer L, Cross CE, Traber MG. 2004. Gene-nutrient interactions exemplified by the ... Mice, Knockout. Lim Y, Schock BC, Gohil K, Leonard SW, Packer L, Cross CE, Traber MG. 2004. Gene-nutrient interactions ... Regulation of the alpha-tocopherol transfer protein in mice: lack of response to dietary vitamin E or oxidative stress.. Lipids ...
TRPV1 Antagonism by Capsazepine Modulates Innate Immune Response in Mice Infected with Plasmodium berghei ANKA
C57BL/6 mice received 10,sup,5,/sup, red blood cells infected with ,i,Plasmodium berghei,/i, ANKA intraperitoneally. ... Noninfected mice were used as controls. Capsazepine or vehicle was given intraperitoneally for 6 days. Mice were culled on day ... Inbred male C57BL/6 mice (8 weeks old) were used. Mice were obtained from the animals facility of the Department of ... C57BL/6 mice received 105 red blood cells infected with Plasmodium berghei ANKA intraperitoneally. Noninfected mice were used ...
Bobby Brooke Herrera, Ph.D. | Harvard Catalyst Profiles | Harvard Catalyst
The Phillips Lab: Research | Department of Biological Sciences | Virginia Tech
2008) and inbred C57BL/6 mice (Muheim et al. 2006) are also being used to investigate the molecular basis of the magnetic ... In related experiments with C57BL/6 mice, we are investigating the role of magnetic cues in a task traditionally used to study ... fields on magnetic compass orientation in mice, birds and larval Drosophila. Frequencies in this range are predicted to alter ... Czech Republic to map central pathways involved in processing magnetic stimuli in the mouse brain, retina, and trigeminal nerve ...
NIOSHTIC-2 Search Results - Full View
Inbred C57BL/6J mice carry two copies of an age-related hearing loss gene (Ahl). It has been shown that these mice begin losing ... The congenic B6.CAST-+Ahl male mice had significantly less TTS immediately post-exposure than C57BL/6J males or females but not ... Non-noise-exposed mice of the same strains and age served as controls. The noise-exposed mice were functionally tested for ABR ... Five each of young C57BL/6J males and females, and B6.CAST-+Ahl males were exposed to a 4-kHz octave band of noise at 108 dB ...
Julie HAINES | Research Assistant Professor | Ph.D. | University of Colorado, CO | UCD | Scientific profile
Animal Welfare in Studies on Murine Tuberculosis: Assessing Progress over a 12-Year Period and the Need for Further Improvement...
This choice is based on the historical relevance of mouse studies in understanding the disease and the present and long- ... using mouse models of tuberculosis (TB) as a case study. ... 2009) Aging in inbred strains of mice: study design and interim ... mice in at least one of the experimental groups, 85% used knockout mice, mostly (82%) on a C57BL/6 background. The use of GM ... used non-genetically modified inbred strains. Of these (n = 231), 44% used solely C57BL/6, 23% BALB/c and 4% other inbred ...
Vaccines targeting tumor blood vessel antigens promote CD8 |sup|+|/sup| T cell-dependent tumor eradication or dormancy in HLA...
Publications | Crick
Genetic Variation in C57BL/6 ES Cells and Knockout Mice | Taconic Biosciences
... inbred mice which are often referred to collectively as "C57BL/6". Different substrains of C57BL/6 mice possess unique genetic ... they breed all mouse lines derived from JM8 ES cells to genetically-matched C57BL/6NTac mice and use C57BL/6NTac mice as wild ... The C57BL/6N branch, from which C57BL/6NTac mice are derived, are more closely related to each other than they are to C57BL/6J ... Using Mice Derived from C57BL/6NTac ES Cells. If you are using a genetically engineered mouse created from a C57BL/6NTac ES ...
Souris Noire de Labo (C57BL/6)
... the breed of black mice known as C57BL/6 is the most well-known and widely used animal models in research. Theyre an inbred ... Souris Noire de Labo (C57BL/6). Souris Noire de Labo (C57BL/6) GMEU-PD-0075 9,95 € ... This particular variety was the sixth sub-strain produced by mating the two C57BL mice. ... He was the first to establish the use of inbred mice in studying genetics.. ...
Adjuvanticity of a synthetic cord factor analogue for subunit Mycobacterium tuberculosis vaccination requires FcRγ-Syk-Card9...
... mice, mice, inbred C57BL, mice, knockout, neoplasm proteins, protein-tyrosine kinases, receptors, IgE, signal transduction, t- ... are effective adjuvants in combination with MTB subunit vaccine candidates in mice. However, it is unknown which signaling ... are effective adjuvants in combination with MTB subunit vaccine candidates in mice. However, it is unknown which signaling ... are effective adjuvants in combination with MTB subunit vaccine candidates in mice. However, it is unknown which signaling ...
NIOSHTIC-2 Search Results - Full View
Inbred C57BL/6J mice carry two copies of an age-related hearing loss gene (Ahl). It has been shown that these mice begin losing ... The congenic B6.CAST-+Ahl male mice had significantly less TTS immediately post-exposure than C57BL/6J males or females but not ... noise-exposed mice of the same strains and age served as controls. The noise-exposed mice were functionally tested for ABR ... Five each of young C57BL/6J males and females, and B6.CAST-+Ahl males were exposed to a 4-kHz octave band of noise at 108 dB ...
Attenuated muscle regeneration is a key factor in dysferlin-deficient muscular dystrophy<...
keywords = "Animals, Cells, Cultured, Disease Models, Animal, Humans, Membrane Proteins, Mice, Mice, Inbred C57BL, Mice, ... Primary mouse dysferlinopathy myoblast cultures show reduced cytokine release upon stimulation, indicating that the secretion ... Primary mouse dysferlinopathy myoblast cultures show reduced cytokine release upon stimulation, indicating that the secretion ... Primary mouse dysferlinopathy myoblast cultures show reduced cytokine release upon stimulation, indicating that the secretion ...
Frontiers | Measuring Behavior in the Home Cage: Study Design, Applications, Challenges, and Perspectives
CB6F1/6J is a hybrid mouse model which comes from breeding two inbred mice (C57BL/6J and BALB/cJ). This animal showed similar ... Compared with C57BL/6J mice, one study found that DBA/2J mice display a more robust and rapid light spot-response (Jankovic et ... Another study of four inbred mouse strains (C57BL/6, DBA/2, C3H and 129S2/Sv) provided the evidence that circadian rhythmicity ... For example, investigation of ambulatory activity of inbred mouse strains (DBA/2 and C57BL/6) across two laboratories (Aberdeen ...
Science Clips - Volume 14, Issue 45, November 8, 2022
We exposed aged male and female C57BL/6J (B6) and DBA/2J (D2) mice to DE, which was cooled and diluted with HEPA-filtered ... inbred mouse strains and both sexes, including whole transcriptome examination of the medial prefrontal cortex. ... These results are important because B6 mice are often used as the default mouse model for DE studies and strain-related effects ... attenuated in mice genetically deficient in IL-11 receptor subunit alpha-1 (IL-11Rα1-deficient mice), a transmembrane receptor ...
Biblio | College of Agricultural Sciences
Biomolecules | Free Full-Text | TRPV1 and TRPA1 Channels Are Both Involved Downstream of Histamine-Induced Itch
... and H4R-induced signal transmission was tested in a scratching assay in mice in vivo as well as via Ca2+ imaging of murine ... They identified the inbred mouse strain C57BL/6 and the outbred strain CD-1 (ICR) as the most susceptible strains to local ... Female and male C57/BL/6 mice (C57/BL/6J, (7 ± 1 weeks old, body weight 20 ± 1 g)), female and male TRPV1−/− mice (B6.129X1- ... and C57BL/6 mice (24%). The majority of 4-MH positive cells isolated from CD-1 (44%) and C57BL/6 mice (77%) were sensitive to ...
PuRe Publikationen | Max-Planck-Institut für molekulare Genetik
Constant Transmission Properties of Variant Creutzfeldt-Jakob Disease in 5 Countries - Volume 18, Number 10-October 2012 -...
... incubation periods were 301-463 days in RIII mice, 361-553 days in VM mice, and 335-553 days in C57BL mice. ... between BSE and vCJD was shown by experimental transmission of the 2 diseases into standard panels of inbred wild-type mouse ... C57BL, and VM mice, whereas in the FVB mice, both diseases exhibit the same pattern of PrPSc deposition (3-5). ... Mouse strains of the same PrP genotype showed close similarities in lesion profiles with Prn-pa mice (RIII and C57BL), showing ...
MMRRC:041996-MU
Strain Detail Sheet for C57BL/6J-MtgxR4795Btlr/Mmmh ... or bred with C57BL/6J inbred mice. ... C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male ... G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving. ... 1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The ...
Frizzled-7 Is Required for Wnt Signaling in Gastric Tumors with and Without Apc Mutations | Cancer Research | American...
Mice were interbred to generate compound mice with appropriate alleles on an inbred C57Bl/6 genetic background. Mice were ... 9 mice; Mann-Whitney). H, qRT-PCR for Wnt target genes in mice described in D (**, P , 0.005, mean ± SEM, n = 9 mice, Mann- ... 9 mice; Mann-Whitney). H, qRT-PCR for Wnt target genes in mice described in D (**, P , 0.005, mean ± SEM, n = 9 mice, Mann- ... 9 mice; Mann-Whitney). F, Quantification of gastric adenomas in mice described in D (***, P , 0.001; mean ± SEM; n = 9 mice; ...