Lymphangiogenesis: The formation of LYMPHATIC VESSELS.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Lymphatic Metastasis: Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.Lymphatic Vessels: Tubular vessels that are involved in the transport of LYMPH and LYMPHOCYTES.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.BooksVascular Endothelial Growth Factor C: A vascular endothelial growth factor that specifically binds to VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2 and VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-3. In addition to being an angiogenic factor it can act on LYMPHATIC VESSELS to stimulate LYMPHANGIOGENESIS. It is similar in structure to VASCULAR ENDOTHELIAL GROWTH FACTOR D in that they both contain N- and C-terminal extensions that were not found in other VEGF family members.Click Chemistry: Organic chemistry methodology that mimics the modular nature of various biosynthetic processes. It uses highly reliable and selective reactions designed to "click" i.e., rapidly join small modular units together in high yield, without offensive byproducts. In combination with COMBINATORIAL CHEMISTRY TECHNIQUES, it is used for the synthesis of new compounds and combinatorial libraries.Lymphatic System: A system of organs and tissues that process and transport immune cells and LYMPH.Vascular Endothelial Growth Factor Receptor-3: A vascular endothelial cell growth factor receptor whose expression is restricted primarily to adult lymphatic endothelium. VEGFR-3 preferentially binds the vascular endothelial growth factor C and vascular endothelial growth factor D and may be involved in the control of lymphangiogenesis.Lymphocytes, Tumor-Infiltrating: Lymphocytes that show specificity for autologous tumor cells. Ex vivo isolation and culturing of TIL with interleukin-2, followed by reinfusion into the patient, is one form of adoptive immunotherapy of cancer.Fibrosarcoma: A sarcoma derived from deep fibrous tissue, characterized by bundles of immature proliferating fibroblasts with variable collagen formation, which tends to invade locally and metastasize by the bloodstream. (Stedman, 25th ed)Macrophages: The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)Methylcholanthrene: A carcinogen that is often used in experimental cancer studies.Basement Membrane: A darkly stained mat-like EXTRACELLULAR MATRIX (ECM) that separates cell layers, such as EPITHELIUM from ENDOTHELIUM or a layer of CONNECTIVE TISSUE. The ECM layer that supports an overlying EPITHELIUM or ENDOTHELIUM is called basal lamina. Basement membrane (BM) can be formed by the fusion of either two adjacent basal laminae or a basal lamina with an adjacent reticular lamina of connective tissue. BM, composed mainly of TYPE IV COLLAGEN; glycoprotein LAMININ; and PROTEOGLYCAN, provides barriers as well as channels between interacting cell layers.Laminin: Large, noncollagenous glycoprotein with antigenic properties. It is localized in the basement membrane lamina lucida and functions to bind epithelial cells to the basement membrane. Evidence suggests that the protein plays a role in tumor invasion.Membrane Proteins: Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.Blood Vessels: Any of the tubular vessels conveying the blood (arteries, arterioles, capillaries, venules, and veins).Lymph Nodes: They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.Stomach Neoplasms: Tumors or cancer of the STOMACH.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Penile Erection: The state of the PENIS when the erectile tissue becomes filled or swollen (tumid) with BLOOD and causes the penis to become rigid and elevated. It is a complex process involving CENTRAL NERVOUS SYSTEM; PERIPHERAL NERVOUS SYSTEMS; HORMONES; SMOOTH MUSCLES; and vascular functions.Penis: The external reproductive organ of males. It is composed of a mass of erectile tissue enclosed in three cylindrical fibrous compartments. Two of the three compartments, the corpus cavernosa, are placed side-by-side along the upper part of the organ. The third compartment below, the corpus spongiosum, houses the urethra.Erectile Dysfunction: The inability in the male to have a PENILE ERECTION due to psychological or organ dysfunction.Cyclic GMP-Dependent Protein Kinases: A group of cyclic GMP-dependent enzymes that catalyze the phosphorylation of SERINE or THREONINE residues of proteins.Cyclic GMP: Guanosine cyclic 3',5'-(hydrogen phosphate). A guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'- and 5'-positions. It is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases. (From Merck Index, 11th ed)Clitoris: An erectile structure homologous with the penis, situated beneath the anterior labial commissure, partially hidden between the anterior ends of the labia minora.Impotence, Vasculogenic: Inability to achieve and maintain an erection (ERECTILE DYSFUNCTION) due to defects in the arterial blood flow to the PENIS, defect in venous occlusive function allowing blood drainage (leakage) from the erectile tissue (corpus cavernosum penis), or both.Congresses as Topic: Conferences, conventions or formal meetings usually attended by delegates representing a special field of interest.Creativity: The ability to generate new ideas or images.Organizations, Nonprofit: Organizations which are not operated for a profit and may be supported by endowments or private contributions.Biological Science Disciplines: All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.Cooperative Behavior: The interaction of two or more persons or organizations directed toward a common goal which is mutually beneficial. An act or instance of working or acting together for a common purpose or benefit, i.e., joint action. (From Random House Dictionary Unabridged, 2d ed)Thinking: Mental activity, not predominantly perceptual, by which one apprehends some aspect of an object or situation based on past learning and experience.Science: The study of natural phenomena by observation, measurement, and experimentation.Mesenchymal Stromal Cells: Bone-marrow-derived, non-hematopoietic cells that support HEMATOPOETIC STEM CELLS. They have also been isolated from other organs and tissues such as UMBILICAL CORD BLOOD, umbilical vein subendothelium, and WHARTON JELLY. These cells are considered to be a source of multipotent stem cells because they include subpopulations of mesenchymal stem cells.Mesenchymal Stem Cell Transplantation: Transfer of MESENCHYMAL STEM CELLS between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS).Adipose Tissue: Specialized connective tissue composed of fat cells (ADIPOCYTES). It is the site of stored FATS, usually in the form of TRIGLYCERIDES. In mammals, there are two types of adipose tissue, the WHITE FAT and the BROWN FAT. Their relative distributions vary in different species with most adipose tissue being white.Authorship: The profession of writing. Also the identity of the writer as the creator of a literary production.Lipectomy: Removal of localized SUBCUTANEOUS FAT deposits by SUCTION CURETTAGE or blunt CANNULATION in the cosmetic correction of OBESITY and other esthetic contour defects.Osteoarthritis: A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.Osteoarthritis, Knee: Noninflammatory degenerative disease of the knee joint consisting of three large categories: conditions that block normal synchronous movement, conditions that produce abnormal pathways of motion, and conditions that cause stress concentration resulting in changes to articular cartilage. (Crenshaw, Campbell's Operative Orthopaedics, 8th ed, p2019)Cholangiocarcinoma: A malignant tumor arising from the epithelium of the BILE DUCTS.Bile Ducts, Intrahepatic: Passages within the liver for the conveyance of bile. Includes right and left hepatic ducts even though these may join outside the liver to form the common hepatic duct.Bile Duct Neoplasms: Tumors or cancer of the BILE DUCTS.Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Liver Neoplasms: Tumors or cancer of the LIVER.Low Density Lipoprotein Receptor-Related Protein-2: An LDL-RECEPTOR RELATED PROTEIN found in the neuroepithelium and in proximal tubular cells of the kidney. It is considered a multiligand receptor in that it binds to a variety of ligands with relatively high affinity and may function in mediating the uptake and lysosomal degradation of macromolecules such as: LIPOPROTEINS; ENDOPEPTIDASES; and PROTEASE INHIBITORS.Proteinuria: The presence of proteins in the urine, an indicator of KIDNEY DISEASES.Malabsorption Syndromes: General term for a group of MALNUTRITION syndromes caused by failure of normal INTESTINAL ABSORPTION of nutrients.Epidemiologic Methods: Research techniques that focus on study designs and data gathering methods in human and animal populations.Albuminuria: The presence of albumin in the urine, an indicator of KIDNEY DISEASES.Vitamin B 12 Deficiency: A nutritional condition produced by a deficiency of VITAMIN B 12 in the diet, characterized by megaloblastic anemia. Since vitamin B 12 is not present in plants, humans have obtained their supply from animal products, from multivitamin supplements in the form of pills, and as additives to food preparations. A wide variety of neuropsychiatric abnormalities is also seen in vitamin B 12 deficiency and appears to be due to an undefined defect involving myelin synthesis. (From Cecil Textbook of Medicine, 19th ed, p848)Kidney Tubules, Proximal: The renal tubule portion that extends from the BOWMAN CAPSULE in the KIDNEY CORTEX into the KIDNEY MEDULLA. The proximal tubule consists of a convoluted proximal segment in the cortex, and a distal straight segment descending into the medulla where it forms the U-shaped LOOP OF HENLE.

*Yihai Cao

"PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis". Cancer Cell. 6 (4): 333-345. doi:10.1016/j. ... They also discovered several lymphangiogenic factors that potentially contribute to cancer metastasis. Cao proposed a new ... a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma". Cell. 79 (2): 315-328. ... of vascular endothelial growth factor receptor-3 signaling inhibits fibroblast growth factor-2-induced lymphangiogenesis in ...

*Vascular endothelial growth factor C

... lymphangiogenesis, and lymphatic metastasis in oral cancer]". Ai Zheng = Aizheng = Chinese Journal of Cancer. 21 (3): 319-22. ... The main function of VEGF-C is in lymphangiogenesis, where it acts on lymphatic endothelial cells (LECs) primarily via its ... "Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis". The EMBO Journal. 20 (4): 672-682 ... "Tumor-associated macrophages express lymphatic endothelial growth factors and are related to peritumoral lymphangiogenesis". ...

*Lymphangiogenesis

... excessive lymphatic vessel formation has been implicated in a number of pathological conditions including neoplasm metastasis, ... Lymphangiogenesis is the formation of lymphatic vessels from pre-existing lymphatic vessels in a method believed to be similar ... Lymphangiogenesis and disease Tumor-induced lymphangiogenesis: [1] Lymphangiogenesis and prosthetic joint failure: [2] ... doi:10.1007/s00441-003-0777-2. Steven A. Stacker (1 July 2009). Lymphangiogenesis in Cancer Metastasis. Springer. pp. 27-. ISBN ...

*Lymphangioleiomyomatosis

... is known for its role in cancer lymphangiogenesis and metastasis. Proteolytic processing of VEGF-D affects cognate binding to ... LAM lesions express lymphatic markers LYVE-1, PROX1, podoplanin and VEGFR-3. The smooth muscle-like cells of AMLs are ... However, little is known about a role of abnormal lymphatics and VEGF-D in LAM pathogenesis. LAM can come to medical attention ... Abnormalities on abdominal imaging, such as renal AML and enlarged lymphatic structures, are also common in LAM. Fat density ...

*MMP2

... which likely increases survival rate of these metastases. Finally, MMP-2 has been also shown to drive lymphangiogenesis, which ... showed that knocking down mmp2 in zebrafish prevented the formation of lymphatic vessels without altering angiogenesis, while ... Altered expression and activity levels of MMPs have been strongly implicated in the progression and metastasis of many forms of ... Finally, MMP inhibitors could be used during earlier stages of cancer to prevent invasion and metastasis. Additionally, tumor ...

*C-fos-induced growth factor

VEGF-D's interactions with VEGFR-3 predominantly expressed in lymphatic vessels plays a key role in restructuring lymphatic ... The structure and function of this protein is similar to those of vascular endothelial growth factor C. Lymph node metastasis ... lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating ... Cancer cells' journey to lymph node takes place largely through lymphatic tunnel located in and around of primary tumor. ...

*Michael Jeltsch

"Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis". The EMBO Journal. 20 (4): 672-82. ... Jeltsch was the first to show that VEGF-C and VEGF-D are the principal growth factors for the lymphatic vasculature and his ... "Hyperplasia of lymphatic vessels in VEGF-C transgenic mice". Science. 276 (5317): 1423-5. doi:10.1126/science.276.5317.1423. ... "CCBE1 Enhances Lymphangiogenesis via A Disintegrin and Metalloprotease With Thrombospondin Motifs-3-Mediated Vascular ...

*LYVE1

This protein may function in lymphatic hyaluronan transport and have a role in tumor metastasis. LYVE-1 is a cell surface ... Cunnick GH, Jiang WG, Gomez KF, Mansel RE (2001). "Lymphangiogenesis quantification using quantitative PCR and breast cancer as ... 2007). "Expression of lymphatic vascular endothelial hyaluronan receptor-1 (LYVE-1) in the human placenta". Lymphatic research ... Lymphatic vessel endothelial hyaluronan receptor 1 (LYVE1), also known as extracellular link domain containing 1 (XLKD1) is a ...

*Lymphovascular invasion

Lymph node metastases usually precede secondary tumours, i.e. distant metastases. The absence of LVI in the context of proven ... Lymphovascular invasion (LVI or lymphovascular space invasion) is spread of a cancer to the blood vessels and/or lymphatics. ... Aug 2004). "Prognostic value of lymphangiogenesis and lymphovascular invasion in invasive breast cancer". Ann Surg. 240 (2): ... Generally speaking, it is associated with lymph node metastases which themselves are predictive of a poorer prognosis. In the ...

*Vascular endothelial growth factor

The overexpression of VEGF-A may be an early step in the process of metastasis, a step that is involved in the "angiogenic" ... Vascular endothelial growth factor-R3 has been detected in lymphatic endothelial cells in CL of many species, cattle, buffalo ... 2013). "Expression and localization of locally produced growth factors regulating lymphangiogenesis during different stages of ... Vascular endothelial growth factor-C can stimulate lymphangiogenesis (via VEGFR3) and angiogenesis via VEGFR2. ...

*Lymphatic system

... and metastasis of cancerous cells from other parts of the body, that have arrived via the lymphatic system. Lymphedema is the ... equivalent for the central nervous system Lymphangiogenesis Lymphangion Manual lymphatic drainage Mononuclear phagocyte system ... Play media The lymphatic system consists of lymphatic organs, a conducting network of lymphatic vessels, and the circulating ... These vessels are also called the lymphatic channels or simply lymphatics. The lymphatics are responsible for maintaining the ...

*Tumor microenvironment

Lymphatic vessels do not usually develop with the tumor, leading to increased interstitial fluid pressure, which may block ... Accordingly, IDO1 genetic deficiency is associated with reduced tumor burden and metastasis and enhanced survival in mouse ... "Tumor-associated macrophages infiltration is associated with peritumoral lymphangiogenesis and poor prognosis in lung ... Chaffer, Christine L.; Weinberg, Robert A. (25 March 2011). "A Perspective on Cancer Cell Metastasis". Science. 331 (6024): ...
Lymphatic growth (lymphangiogenesis) within lymph nodes functions to promote dendritic cell entry and effector lymphocyte egress in response to infection or inflammation. Here we demonstrate a crucial role for lymphotoxin-beta receptor (LT beta R) signaling to fibroblastic reticular cells (FRCs) by lymphotoxin-expressing B cells in driving mesenteric lymph node lymphangiogenesis following helminth infection. LT beta R ligation on fibroblastic reticular cells leads to the production of B-cell-activating factor (BAFF), which synergized with interleukin-4 (IL-4) to promote the production of the lymphangiogenic factors, vascular endothelial growth factors (VEGF)-A and VEGF-C, by B cells. In addition, the BAFF-IL-4 synergy augments expression of lymphotoxin by antigen-activated B cells, promoting further B cell-fibroblastic reticular cell interactions. These results underlie the importance of lymphotoxin-dependent B cell-FRC cross talk in driving the expansion of ...
Tumor-associated lymphangiogenesis is considered significant in number of solid malignancies. However, its impact on prognosis of intrahepatic cholangiocarcinoma (ICC) after resection remains further confirmation. Herein, we conducted this study to evaluate prognostic impact of tumor-associated lymphangiogenesis in patients with ICC. Extent of tumor-associated lymphangiogenesis of ICC was evaluated by quantifying microlymphatic vessel density (MLVD) from immunohistochemical staining of a lymphatic endothelial-specific antibody (podoplanin). Clinicopathological characteristics were comprehensively analyzed to identify MLVD-associated factors. The patients were stratified into high and low MLVD groups according to the distinctive correlation between the MLVD and overall survival using the Spearmans correlation test. Kaplan-Meier estimation was performed to confirm prognostic impact of MLVD in patients with ICC. Univariate and ...
The formation of lymphatic vessels from pre-existing lymphatic vessels, in a method believed to be similar to blood vessel development or angiogenesis. See also: * Lymphedema * Pathophysiology of Lymphedema Lymphedema Genetics Genetics, Research, Lymphangiogenesis, Angiogenesis The Formation of Lymphatic Vessels and Its Importance in the Setting of Malignancy Lymphangiogenesis Breast Cancer the VEGF-C Lymphangiogenesis and Gastric Cancer Lymphangiogenesis in Head and Neck Cancer Lymphangiogenesis and Kaposis Sarcoma VEGF-C Lymphangiogenesis and Melanoma Lymphangiogenesis in Wound Healing A model for gene therapy of human hereditary lymphedema VEGFR-3 Ligands and Lymphangiogenesis (1) VEGFR-3 Ligands and Lymphangiogenesis (2) VEGFR-3 Ligands and Lymphangiogenesis (3) Vascular Endothelial ...
To study a possible role of sentinel LN angiogenesis and lymphangiogenesis in lymphatic dissemination in patients with breast cancer, we have investigated the association of these processes-quantified as ECP% and LECP%, respectively-with the presence of nonsentinel LN metastases in breast cancer patients with a positive sentinel node biopsy. Increased lymphangiogenesis, not angiogenesis, was associated with an increased frequency of involved nonsentinel LNs. In the multivariate model, LECP% was independently associated with the presence of nonsentinel LN metastases.. These findings support the hypothesis that sentinel LN lymphangiogenesis is involved in further lymphatic spread of human breast cancer. As previously mentioned, most animal studies on sentinel LN lymphangiogenesis focused on its role in the premetastatic remodeling of the sentinel LN (premetastatic niche). However, some data from these models ...
Metastasis of breast cancer occurs primarily through the lymphatic system, and the extent of lymph node involvement is a key prognostic factor for the disease. Whereas the significance of angiogenesis for tumor progression has been well documented, the ability of tumor cells to induce the growth of lymphatic vessels (lymphangiogenesis) and the presence of intratumoral lymphatic vessels have been controversial. Using a novel marker for lymphatic endothelium, LYVE-1, we demonstrate here the occurrence of intratumoral lymphangiogenesis within human breast cancers after orthotopic transplantation onto nude mice. Vascular endothelial growth factor (VEGF)-C overexpression in breast cancer cells potently increased intratumoral lymphangiogenesis, resulting in significantly enhanced metastasis to regional lymph nodes and to lungs. ...
The formation of new lymphatic vessels, or lymphangiogenesis, is a natural process involved in tissue repair and in the resolution of inflammatory reactions. In some cancers, this process is exploited by the tumor to promote its growth and its metastatic dissemination. Our group recently identified a role for the CD73-adenosine pathway in tumor angiogenesis. As angiogenesis and lymphangiogenesis are similar processes, often occurring in parallel, we suspect that the CD73-adenosine pathway could have a role in the regulation of lymphangiogenesis during inflammatory reactions and in the tumor microenvironment.. To confirm this hypothesis, we used in vivo models of inflammatory lymphangiogenesis induced by the administration of lipopolysaccharide (LPS) or Incomplete Freunds Adjuvant (IFA) in the peritoneal cavity of mice. These two models of peritonitis trigger the formation of new lymphatics in the diaphragm ...
NSAIDs May Prevent the Development of Colorectal Cancer after Polyp Removal This post focuses on a recent study published in the British Medical Journal that suggests that NSAIDs may help prevent colorectal cancer after polyp removal - This post goes into more detail on the study. Frank Magliochetti Taking non-steroidal anti-inflammatory drugs (NSAIDs) may prevent the recurrence of advanced neoplasia, a type of polyp that is the precursor of colorectal cancer, after the surgical removal of pre-existing polyps. Recurrence rates of benign polyps and advanced neoplasia are quite high, so clinicians are eager to find easy-to-follow treatments to reduce recurrence. A team of scientists from across the United States recently collaborated with Mayo Clinic researchers to determine how well NSAIDs, aspirin and other supplements prevent the recurrence of precancerous or cancerous polyps. The results of the study, published in the British medical journal BMJ suggest NSAIDs may offer the greatest ...
To determine the effect of celecoxib on lymphangiogenesis in Nasopharyngeal carcinoma Lymphangiogenesis and factors modulating lymphangiogenesis are associated with clinico-pathological outcome in Nasopharyngeal carcinoma and colorectal cancer. Celecoxib down-regulates lymphangiogenesis Archival colorectal cancer and Nasopharyngeal carcinoma tumor specimens will be obtained from the Department of Pathology. To determine the effect of celecoxib on lymphangiogenesis in Nasopharyngeal carcinoma, the investigators intend to analyze archived specimens collected in a previously conducted study. Colorectal tumor and nodal specimens and Nasopharyngeal carcinoma primary will be examined for MVD, LVD and growth factor expression using established haematoxylin and eosin and immunohistochemical techniques. Quantification of LVD and MVD shall be performed by two pathologists blinded to clinico-pathological variables using standardised ...
The British Medical Journal has had problems with two papers about primary prevention of coronary artery disease (heart disease). Both papers have data that demonstrate statins have no use in primary prevention for most patients. The British Medical Journal problems relate to power, money and censorship. In this text a teacher explain the situation to her students.. ...
The Clinical Journal of the American Society of Nephrology is a monthly peer-reviewed medical journal covering nephrology. It was established in 2006 and is published by the American Society of Nephrology. The editor-in-chief is Gary Curhan (Harvard Medical School). According to the Journal Citation Reports, the journal has a 2014 impact factor of 4.613. The journal is abstracted and indexed in the following databases: CINAHL Current Contents/Clinical Medicine MEDLINE Science Citation Index Scopus "Clinical Journal of the American Society of Nephrology". 2014 Journal Citation Reports. Web of Science (Science ed.). Thomson Reuters. 2015. Official ...
Health,British Medical Journal is celebrating 166 years of its publication. T... The journal launched in 1840 has listed 15 medical breakthroughs ... The modern miracles include anesthesia antibiotics chlorpromazin...BMJ readers compiled the list from more than 100 nominations chosen ... Cheerleaders for each medical milestone have been chosen. They i...,And,the,Winner,Is,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
Purpose.: To analyze whether insulin receptor substrate (IRS-1) is involved in lymphatic vessel development and whether IRS-1 blockade can inhibit lymphangiogenesis in vivo. Methods.: The impact of IRS-1 blockade by GS-101 (Aganirsen), an antisense oligonucleotide against IRS-1, on lymphatic endothelial cell (LEC) proliferation was assessed by ELISA. Furthermore, the effect of IRS-1 blockade on prolymphangiogenic growth factor expression by LECs and macrophages (peritoneal exudate cells) was tested by real-time PCR. The mouse model of inflammatory corneal neovascularization was used to analyze the effect of IRS-1 blockade in vivo: after corneal suture placement, mice were treated with GS-101 eye drops (twice daily afterwards for 1 week, 5 μL per drop; 50, 100, or 200 μM). Afterward, corneal wholemounts were prepared and stained for blood and lymphatic vessels. Results.: Blockade of IRS-1 by GS-101 inhibited LEC proliferation dose ...
Members of the committee are Marcia Angell (The New England Journal of Medicine), Linda Hawes Clever (Western Journal of Medicine), Lois Ann Colaianni (Index Medicus), Robert Fletcher and Suzanne Fletcher (Annals of Internal Medicine), Jill Forrest (The Medical Journal of Australia), Robin Fox (The Lancet), Richard Glass (Journal of the American Medical Association), Jerome P. Kassirer (The New England Journal of Medicine), George Lundberg (Journal of the American Medical Association), Magne Nylenna (Tidsskrift for den Norske Laegeforening), Richard Robinson (New Zealand Medical Journal), Richard Smith (British Medical Journal), Bruce Squires (Canadian Medical Association Journal), Laurel Thomas (The Medical Journal of Australia), and Patricia Woolf. Please address comments to Kathleen Case, Secretariat (Annals of Internal Medicine ...
In melanoma, vascular endothelial growth factor-C (VEGF-C) expression and consequent lymphangiogenesis correlate with metastasis and poor prognosis. VEGF-C also promotes tumor immunosuppression, suggesting that lymphangiogenesis inhibitors may be clinically useful in combination with immunotherapy. We addressed this concept in mouse melanoma models with VEGF receptor-3 (VEGFR-3)-blocking antibodies and unexpectedly found that VEGF-C signaling enhanced rather than suppressed the response to immunotherapy. We further found that this effect was mediated by VEGF-C-induced CCL21 and tumor infiltration of naïve T cells before immunotherapy because CCR7 blockade reversed the potentiating effects of VEGF-C. In human metastatic melanoma, gene expression of VEGF-C strongly correlated with CCL21 and T cell inflammation, and serum VEGF-C concentrations associated with both T cell activation and expansion after peptide vaccination and clinical response ...
TY - JOUR. T1 - VEGFR-3 neutralization inhibits ovarian lymphangiogenesis, follicle maturation, and murine pregnancy. AU - Rutkowski, Joseph M.. AU - Ihm, Jong Eun. AU - Lee, Seung Tae. AU - Kilarski, Witold W.. AU - Greenwood, Veronique I.. AU - Pasquier, Miriella C.. AU - Quazzola, Alexandra. AU - Trono, Didier. AU - Hubbell, Jeffrey A.. AU - Swartz, Melody A.. PY - 2013/11/1. Y1 - 2013/11/1. N2 - Lymphatic vessels surround follicles within the ovary, but their roles in folliculogenesis and pregnancy, as well as the necessity of lymphangiogenesis in follicle maturation and health, are undefined. We used systemic delivery of mF4-31C1, a specific antagonist vascular endothelial growth factor receptor 3 (VEGFR-3) antibody to block lymphangiogenesis in mice. VEGFR-3 neutralization for 2 weeks before mating blocked ovarian lymphangiogenesis at all stages of follicle maturation, most notably around corpora lutea, without ...
Moreover, our in vitro data demonstrate that LECs with Itga-9 depletion lost their ability to form capillary type tubes in culture. However, our in vivo treatment regimen with the Itga-9 blocking antibody shows no significant reduction of lymphatic vessels but valves. Nevertheless, this discrepancy phenomenon is also observed in a previous study on lymphatic valve formation in nonocular tissues during development. Particularly, Bazigou et al.23 examined lymphatic valve formation in Itga-9 knockout mice and reported reduced number of valves, but not lymphatic vessels, in Itga-9 homozygotes. One possible explanation for our in vivo data with the neutralizing antibody is that Itga-9 is more highly expressed on corneal lymphatic valves than vessels,16,17 which may render the valves more sensitive to the anti-Itga-9 treatment. This warrants further investigation. Taken together, these results designate Itga-9 as an ideal target ...
The Lancet is a weekly peer-reviewed general medical journal. It is one of the worlds oldest and best known general medical journals. The Lancet was founded in 1823 by Thomas Wakley, an English surgeon who named it after the surgical instrument called a lancet, as well as after the architectural term "lancet arch", a window with a sharp pointed arch, to indicate the "light of wisdom" or "to let in light". The Lancet publishes original research articles, review articles ("seminars" and "reviews"), editorials, book reviews, correspondence, as well as news features and case reports. The Lancet has been owned by Elsevier since 1991. As of 2015[update], the editor-in-chief is Richard Horton. The journal has editorial offices in London, New York, and Beijing. In the 2014 Journal Citation Reports, The Lancet was ranked second among general medical journals, (with an impact factor of 45), after The New England Journal of Medicine (impact factor of 56). The Lancet also publishes several specialty ...
Vascular endothelial growth factor (VEGF)-C and VEGF-D induce lymphangiogenesis through activation of VEGF receptor 3 (VEGFR-3) and have been implicated in tumor spread to the lymphatic system. Lymph node dissemination critically determines clinical outcome and therapeutic options of patients with non-small cell lung cancer (NSCLC). However, the relationship of VEGF-C, VEGF-D, and lymph node metastasis in cancers, including NSCLC, is still controversial. To evaluate the relationship between lymphangiogenesis and lymph node metastasis, the expression of VEGF-C and VEGF-D in NSCLC tumors were detected by immunohistochemistry and quantitative real-time polymerase chain reaction (QRT-PCR). QRT-PCR revealed that in marginal region VEGF-C and VEGF-D mRNA was significantly higher than in tumor center, and VEGF-D mRNA was also higher than that in peritumoral lung tissue. Immunohistochemically, we ...
Rationale: Lymphatic vessels in the respiratory tract normally mature into a functional network during the neonatal period, but under some pathological conditions they can grow as enlarged, dilated sacs that result in the potentially lethal condition of pulmonary lymphangiectasia. Objective: We sought to determine whether overexpression of the lymphangiogenic growth factor (vascular endothelial growth factor-C [VEGF-C]) can promote lymphatic growth and maturation in the respiratory tract. Unexpectedly, perinatal overexpression of VEGF-C in the respiratory epithelium led to a condition resembling human pulmonary lymphangiectasia, a life-threatening disorder of the newborn characterized by respiratory distress and the presence of widely dilated lymphatics. Methods and Results: Administration of doxycycline to Clara cell secretory protein-reverse tetracycline-controlled transactivator/tetracycline operator-VEGF-C double-transgenic mice during a critical period ...
The current meta-analysis study indicates that both lymphatic vessel density and lymphovascular invasion presence can predict poor prognosis in females with breast cancer. Compared with the high lymphatic vessel density, the presence of lymphovascular invasion in breast cancer appears to have weaker impacts on DFS and OS; but it is also significantly associated with poor survival. Furthermore, lymphovascular invasion was present in 29.56% of breast cancer patients, who would have poorer prognosis.. The metastasis routes of breast cancer consist of local invasion, hematogenous metastasis, and lymphatic metastasis. New blood and lymphatic vessels formed through physiological or pathological processes are called angiogenesis and lymphangiogenesis, respectively. It is well known that tumor angiogenesis, and its indicator blood ...
Background: Vascular endothelial growth factor-C (VEGF-C), a homologue of VEGF family, plays a key role in lymphangiogenesis. Recently, we demonstrated that VEGF-C is closely associated with dyslipidemia and atherosclerosis. However, the relationship between serum VEGF-C levels and cardiovascular events in patients with atherosclerotic disease is unknown.. Methods and Results: We performed a prospective cohort study involving a total of 209 patients with arteriosclerotic obliterans (ASO) (age, 73±8 y [SD]; male, 75%; hypertension, 88%; diabetes, 69%; dyslipidemia, 72%; history of smoking, 76%; Fontaine class, 2.1±0.8). Serum levels of VEGF-C, VEGF-A and high-sensitivity C-reactive protein (hsCRP) were determined employing specific enzyme-linked immunosorbent assays. The primary outcome was major adverse cardiac events (MACEs) defined as all-cause mortality, hospitalization due to acute coronary syndrome, stroke, congestive heart failure, aortic disease, and coronary/peripheral ...
The mucin-type glycoprotein podoplanin is specifically expressed by lymphatic but not blood vascular endothelial cells in culture and in tumor-associated lymphangiogenesis, and podoplanin deficiency results in congenital lymphedema and impaired lymphatic vascular patterning. indicated by granulosa cells in regular ovarian follicles highly, and by ovarian granulosa and dysgerminomas cell tumors. Although podoplanin was absent from regular human being epidermis mainly, its manifestation was induced in 22 of 28 squamous cell carcinomas studied strongly. These findings recommend a potential part of podoplanin in tumor development, plus they also determine the 1st commercially obtainable antibody for the precise staining of a precise lymphatic marker in archival human being tissue sections, allowing more widespread research of tumor lymphangiogenesis in human cancers thereby. Lymphatic vessels play a significant ...
Phage-Derived Fully Human Monoclonal Antibody Fragments to Human Vascular Endothelial Growth Factor-C Block Its Interaction with VEGF Receptor-2 and ...
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In this review, the role of angiogenic and lymphangiogenic growth factors in hematological malignancies is summarized, alongside with possible therapeutic applications. Recent data demonstrate the importance of angiogenesis in hematologic malignancies including leukemia, lymphoma, and multiple myeloma. Expression of angiogenic polypeptides vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) associate with clinical characteristics in human leukemia and lymphoma, and their serum concentrations serve as predictors of poor prognosis. VEGF and VEGF-C also act as survival factors on leukemia. Furthermore, certain hematological malignancies both produce angiogenic or lymphangiogenic growth factors including VEGF and VEGF-C, and also express their receptors, resulting in the generation of autocrine loops that may support cancer cell survival and proliferation. Inhibition of the action of key regulators of endothelial cell growth, alone or in combination with other antiangiogenic
Background: Metastasis to regional lymph nodes (LNs) through lymphatic vessels is common in cancer progression and is an important prognostic factor in many cancers. Recent evidence suggests that tumour lymphangiogenesis promotes lymphatic metastasis.. Aims: To study the role of lymph vessel density (LVD) in gastric cancer and investigate whether LVD is associated with LN metastasis/prognosis.. Methods: Lymphatics of 117 primary human gastric cancer cases were investigated by quantitative immunohistochemical staining for podoplanin. The relation between LVD and LN metastasis and other established clinicopathological parameters was analysed. The relation between LVD and prognosis was also studied.. Results: Mean LVD of "hot spots" was 11.6/case. LVD significantly correlated with LN and podoplanin positive ...
Dry eye disease (DED) is one of the most common ocular surface diseases, affecting millions of individuals. Over the last years it became a public health disorder, concerning especially the elderly. Patients who suffer from dry eye, report symptoms like dryness, irritation and decreased visual acuity leading to a loss of lifes quality. Even if the underlying immunopathogenesis has been verified in recent years more and more accurately, no causal treatment is available due to the various factors triggering dry eye disease and its self-intensifying viscious circle. Artificial tears and anti-inflammatory eye drops are nowadays the conventional therapy. Thus the identification of new treatment strategies is essential. Recent data suggest that the anti-angiogenic privilege, which maintains the transparency of the cornea and preserves high visual acuity, is disturbed in DED leading to a selective and spontaneous outgrowth of lymphatic vessels. These vessels are known as risk factor for corneal ...
https://doi.org/10.18632/oncotarget.12978 Olaia Martínez-Iglesias, David Olmeda, Elvira Alonso-Merino, Sara Gómez-Rey, Ana M. González-López, Enrique Luengo, María S. Soengas, José Palacios, Javier...
The lymphatic vascular system maintains tissue fluid homeostasis, helps mediate afferent immune responses, and promotes cancer metastasis. To address the role microRNAs (miRNAs) play in the development and function of the lymphatic vascular system, we defined the in vitro miRNA expression profiles of primary human lymphatic endothelial cells (LECs) and blood vascular endothelial cells (BVECs) and identified four BVEC signature and two LEC signature miRNAs. Their vascular lineage-specific expression patterns were confirmed in vivo by quantitative real-time PCR and in situ hybridization. Functional characterization of the BVEC signature miRNA miR-31 identified a novel BVEC-specific posttranscriptional regulatory mechanism that inhibits the expression of lymphatic lineage-specific transcripts in vitro. We demonstrate that suppression of lymphatic differentiation is partially mediated via direct ...
The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. The encoded protein promotes angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. The proprotein is further cleaved into a fully processed form that can bind and activate VEGFR-2 and VEGFR-3 receptors. [provided by RefSeq, Apr 2014 ...
In glaucoma, aqueous outflow into the Schlemms canal (SC) is obstructed. Despite striking structural and functional similarities with the lymphatic vascular, system, it is unknown whether the SC is a blood or lymphatic vessel. Here, we demonstrated the expression of lymphatic endothelial cell markers by the SC in murine and zebrafish models as well as in human eye tissue. The initial stages of SC development involved induction of the transcription factor PROX1 and the lymphangiogenic receptor tyrosine kinase VEGFR-3 in venous endothelial cells in postnatal mice. Using gene deletion and function-blocking antibodies in mice, we determined that the lymphangiogenic growth factor VEGF-C and its receptor, VEGFR-3, are essential for SC development. Delivery of VEGF-C into the adult eye resulted in sprouting, proliferation, and growth of SC endothelial cells, whereas VEGF-A obliterated the aqueous outflow system. Furthermore, a single injection of recombinant VEGF-C ...
When DArcy Wentworth Thompsons On Growth and Form was published 100 years ago, it raised the question of how biological forms arise during development and across evolution. In light of the advances in molecular and cellular biology since then, a succinct modern view of the question states: how do genes encode geometry? Our new special issue is packed with articles that use mathematical and physical approaches to gain insights into cell and tissue patterning, morphogenesis and dynamics, and that provide a physical framework to capture these processes operating across scales.. Read the Editorial by guest editors Thomas Lecuit and L. Mahadevan, as they provide a perspective on the influence of DArcy Thompsons work and an overview of the articles in this issue.. ...
OBJECTIVE: To investigate the antiangiogenesis mechanism of epigallocatechin-3-gallate (EGCG) in an endometriosis model in vivo. DESIGN: Animal studies. SETTING: University laboratory. ANIMAL(S): Human endometrium from women with endometriosis (n = 10) was transplanted into immunocompromised mice. INTERVENTION(S): Mice (n = 30) were randomly treated with EGCG, vitamin E (antioxidant control), or vehicle (negative control) for microvessel imaging. MAIN OUTCOME MEASURE(S): Endometriotic implants were collected for angiogenesis microarray and pathway analysis. Differentially expressed angiogenesis molecules were confirmed by quantitative polymerase chain reaction, Western blot, and immunohistochemistry. Effects of EGCG on angiogenesis signal transduction were further characterized in a human endothelial cell line. Microvessel parameters and the angiogenesis signaling pathway in endometriotic implants and endothelial cells were studied. RESULT(S): EGCG, but not vitamin E, inhibited microvessels in
The lymphatic system also serves as a connection between tissues and the bloodstream, performing several functions such as removing dead blood cells and other waste.. Thus, important functions of the lymphatic system are to remove.The key function of the lymphatic system is to bring together and transport tissue fluids from the intercellular spaces that does gas exchange, water.It transports white blood cells to and from the lymph nodes into the bones.The lymphatic system is an additional channel for interstitial fluid from the tissue spaces to return to the bloodstream.The lymphatic system consists of a fluid (lymph), vessels that transport the lymph, and organs that contain lymphoid tissue.Lymphatic system absorbs fluid from the interstitial tissues which is called lymph and it passes back into the blood.The 10 percent that does not return becomes part of the interstitial fluid that surrounds the tissue ...
Lymphatic valves are normally devoid of SMCs; however, Sweet et al. identified SMCs in the lymphatic valves of Clec2 mutant mice. This aberration was likely caused by the impairment of valve formation. It should be noted that similar phenotypes have been reported in Foxc2 and Gata2 mutant mice (6, 11). The GATA2 transcription factor also plays a key role in hematopoiesis during development and postnatal life (12), and most GATA2 missense mutations are associated with hematological disorders. However, a subset of patients with heterozygous GATA2 mutations develop Emberger syndrome (OMIM 614038), which is characterized by primary lymphedema and a predisposition for myelodysplasia and acute myeloid leukemia (12). GATA2 is known to function in vascular integrity and lymphatic vessel patterning (13, 14), and is also highly expressed in lymphatic valves (15). Kazenwadel et al. report that GATA2 and PROX1 are coexpressed in lymphovenous and ...
Methods Allogeneic fully MHC-mismatched C57Bl/6 strain donor corneas were transplanted into naive A/J mice and into A/J mice with active allergic conjunctivitis. Further groups of allograft recipients with allergic conjunctivitis were treated post-operatively with twice daily topical dexamethasone 0.1% or phosphate-buffered saline. Mice were killed on days 2 and 6 and corneas were examined by (i) fluorescent immunohistochemistry of frozen sections using anti-CD11b, anti-F4/80 and anti-Gr-1 antibodies, or (ii) whole-mount staining with anti-LYVE-1 antibody. Lymphatic ingrowth and numbers of cells infiltrating the host cornea were compared between groups. ...
TY - JOUR. T1 - Immunohistochemical demonstration of lymphatic vessels in human dental pulp. AU - Sawa, Yoshihiko. AU - Yoshida, Shigemitsu. AU - Ashikaga, Yuichi. AU - Kim, Takenori. AU - Yamaoka, Yuji. AU - Suzuki, Masatsugu. PY - 1998. Y1 - 1998. N2 - The existence of lymphatic vessels in dental pulp has been a matter of continuing controversy because of the difficulty of discriminating them in ordinary stained tissue sections. Recently, we have succeeded in establishing a new identification method for lymphatic vessels in human frozen sections by using a commercial monoclonal antibody specific for the human thoracic duct and anti-human laminin antiserum. The present study aimed to examine the lymphatic vessels in human dental pulp using the new immunostaining method, and compared the results with those in human small intestine. The study clearly demonstrated the distribution of lymphatic vessels in human dental pulp. ...
The immune system uses lymphatic vessels to exchange immune cells and soluble mediators with tissues and organs, but the CNS does not contain lymphatic vessels. Or, does it?. Here are a few notable examples that illustrate the current view - or, as we will see, an outdated view - on the presence of lymphatic vessels in the CNS. "Lymphatic vessels are not found in CNS tissue", states an article published in 2003 in Nature Review Immunology. According to an article that appeared in the scientific journal Immunological Reviews in 2006: "It is an undisputed anatomical fact that the CNS lacks a traditional lymphatic system." A similar statement related to the CNS - "the lack of an obvious lymphatic system" - is present in an article published in 2010 in the Journal of Clinical Investigation. Even a very recent (February 2015) article published in the journal Brain, Behavior, and Immunity, states that "the CNS ...
The researchers applied vascular endothelial growth factor-C (VEGF-C) gene therapy in mice after surgery removal of axillary lymph nodes, a procedure that mimicked removal of axillary lymph nodes in patients in response to metastatic breast cancer. They found that treatment of lymph node-excised mice with adenoviral VEGF-C gene transfer vectors induced robust growth of the lymphatic capillaries, which gradually underwent an intrinsic remodeling, differentiation and maturation program into functional collecting lymphatic vessels, including formation of uniform endothelial cell-cell junctions and intraluminal valves. As VEGF-C quite potently increases the rate of lymph node metastasis, the researchers sought to develop a mode of therapy that could be safely applied also in patients that had been treated for cancer. They established that the VEGF-C therapy greatly improved the outcome of lymph node transplantation. As a result, they were able ...
Background: Vascular endothelial growth factor-A (VEGF-A) plays a pivotal role in cardiac angiogenesis and is required for preventing the transition from compensatory left ventricular hypertrophy (LVH) to heart failure (HF). Vascular endothelial growth factor-C (VEGF-C), a homologue of the VEGF family, plays a key role in lymphangiogenesis. However, the relationship between VEGF-C and HF is unknown.. Methods and Results: We carried out a cross-sectional study involving 401 outpatients whose New York Heart Association functional classes were stable for at least 3 months. We performed echocardiography and calculated the left ventricular ejection fraction (LVEF) and left ventricular mass index (LVMI). Serum levels of N-terminal pro-brain natriuretic peptide (NT-proBNP), VEGF-A, and VEGF-C were determined employing specific enzyme-linked immunosorbent assays. Patients were divided into three groups: those with systolic dysfunction (HF+; LVEF , 50%), those with LVH and a preserved systolic ...
Aims: To assess lymphatic vascular density (LVD) and lymph vessel endothelial proliferation in a series of carcinoma ex pleomorphic adenoma (CXPA) that represents the tumour in the different carcinogenesis phases and tumour progression.. Methods: In 8 cases of early CXPA (intracapsular and minimally invasive tumours), 8 of advanced CXPA (widely invasive tumours) and 10 of pleomorphic adenoma (PA) without malignant transformation, lymphatic vessels and proliferating cells were detected using the antibodies D2-40 and Ki-67 respectively.. Results: Comparing early tumours with advanced ones, LVD was not significantly different at the tumour margin. In contrast, regarding intratumoural lymphatics, PA without malignant transformation and early CXPA contained rare, if any, lymph vessels, whereas in widely invasive carcinomas they were more numerous. However, neither intratumoural nor peritumoural LVD were increased in comparison to adjacent normal salivary gland ...
Rationale: The emergence of lymphatic endothelial cells (LECs) appears to be highly regulated during development. While several factors that promote the differentiation of LECs in embryonic development have been identified, those that negatively regulate this process are largely unknown. Objective: To delineate the role of BMP2 signaling on lymphatic development. Methods and Results: BMP2 signaling negatively regulates the formation of LECs. Developing LECs lack any detectable BMP signaling activity in both zebrafish and mouse embryos, and excess BMP2 signaling in zebrafish embryos and mouse embryonic stem (ES) cell-derived embryoid bodies (EBs) substantially decrease the emergence of LECs. Mechanistically, BMP2 signaling induces expression of miR-31 and miR-181a in a SMAD-dependent mechanism, which in turn, result attenuated expression of PROX1 during development. Conclusions: Our data identify BMP2 as a key negative regulator for the emergence of the ...
Lymph Vessels Lymph vessels what are lymphatic vessels with pictures. Lymph vessels the lymphatic system free. Lymph vessels definition of lymph vessel nci dictionary of cancer terms download. Lymph Vessels Lymph vessels lymphatic vessel wikipedia download. Lymph vessels lesson 8 the circulatory system download. Lymph vessels lymphatic vessels and normal blood volume free. Lymph Vessels ...
Supplement In human lymphatic system, the lymphatics (or lymphatic vessels) are the channels that convey the colorless, alkaline fluid called lymph. The lymphatics include the lymph capillaries (which are the smallest channels of the lymphatic system), the collecting lymph vessels with valves, and the lymphatic ducts, which are the terminal lymphatic vessels that empty to the subclavian veins. There are two major lymphatic ducts in human lymphatic system. These are the right lymphatic duct and the thoracic duct. The right thoracic duct is about 1.25 cm in length. It is formed through the union of the right jugular lymphatic vessel and the vessels from the lymph nodes of the right upper extremity, thoracic wall, and both lungs.1 The right lymphatic duct drains lymph fluid into the bloodstream from the upper ...
Several lymphangiogenic factors, such as vascular endothelial growth factors (VEGFs), have been found to drive the development of lymphatic metastasis in bladder cancer (BCa).Here, we have analyzed the gene expression of lymphangiogenic factors in tissue specimens from 12 non-muscle invasive bladder cancers (NMIBC) and 11 muscle invasive bladder cancers (MIBC), considering tumor and tumor-adjacent normal bladder areas obtained from the same organs. We then compared the results observed in patients with those obtained after treating human primary bladder microvascular endothelial cells (MEC) with either direct stimulation with VEGF-A or VEGF-C or by co-culturing (trans-well assay) MEC with bladder cancer cell lines varying in VEGF-A and VEGF-C production based on tumor grade ...
LAM also occurs in patients who do not have TSC. This form, termed "sporadic LAM" or "S-LAM," is diagnosed in at least 2.5-5 per million women, or roughly 10,000 women worldwide, although it is likely that S-LAM is substantially underdiagnosed. To date, only one biopsy-documented case of S-LAM in a male has been reported. Although less common, most patients seen in the clinic have S-LAM rather than TSC-LAM.. In LAM, lung destruction occurs as a result of neoplastic proliferation of benign-appearing smooth muscle cells in the lung. Genetic evidence indicates that the LAM cells that infiltrate the lung arise from an unknown extrapulmonary source and spread via the bloodstream and lymphatics. Leading candidates for the site of origin include the uterus, renal angiomyolipomas, and lymphatics. LAM cells express the lymphangiogenic growth factors VEGF-C and VEGF-D and induce disordered lymphatic channel formation in the lung and lymphatics. ...
Le Guen, Ludovic, Karpanen, Terhi, Schulte, Dorte, Harris, Nicole C., Bower, Neil, I., Koltowska, Katarzyna, Roukens, Guy, Van Impel, Andreas, Stacker, Steven A., Achen, Marc, Schulte-Merker, Stefan and Hogan, Ben M. (2014). Ccbe1 regulates Vegfc-mediated induction of Vegfr3 signaling during embryonic lymphangiogenesis. In: Abstracts - Vascular matrix biology and bioengineering workshop IV and biology of signaling in the cardiovascular system workshop III. Vascular matrix biology and bioengineering workshop IV and biology of signaling in the cardiovascular system workshop III, Hyannis, MA United States, (279-280). 20 - 24 October 1013. doi:10.1007/s10456-013-9412-3 ...
The flow of fluids along a boundary, such as occurs at the inner lining of vascular tissue, produces shear stress force. Fluid shear forces influence several developmental and pathological processes, including cardiovascular development and atherosclerosis. The lymphatic vascular system is a low-pressure, low-flow system that carries lymph through an intricate network of vessels to the venous system. As primary lymphatic vessels mature into collecting vessels, they develop valves that prevent lymph backflow. Daniel Sweet and colleagues at the University of Pennsylvania determined that proper flow of lymph is required to initiate the transcriptional program in lymphatic endothelial cells (LECs) that directs lymphatic vessel maturation. The authors took advantage of platelet receptor CLEC2-deficient mice, which have blocked lymph flow as the result of back-flow of venous blood into the lymphatic vascular system. While primary ...
Although the ability of a high-salt diet (HSD) to promote hypertension in some people has been recognized for decades, the underlying mechanisms remain incompletely understood (see Marvar et al.). Machnik et al. found that rats fed a HSD developed hyperplasia of the lymph capillary network, accompanied by increased numbers of interstitial mononuclear phagocyte system (MPS) cells in skin and changes in skin water and electrolyte content consistent with interstitial Na+ accumulation. Most of the infiltrating MPS cells were immunoreactive for vascular endothelial growth factor-C (VEGF-C, which stimulates lymphangiogenesis), and their depletion inhibited HSD-induced lymph capillary network hyperplasia, as well as HSD-mediated increases in skin abundance of VEGF-C and of the transcription factor TonEBP (tonicity-responsive enhancer binding protein). Moreover, MPS cell depletion exacerbated the HSD-induced increase in mean arterial blood pressure, as well as an HSD-induced increase in skin ...
Cancer metastasis contributes significantly to cancer mortality and is facilitated by lymphangiogenesis and angiogenesis. A new splicing variant, endogenous soluble vascular endothelial growth factor receptor-2 (esVEGFR-2) that we recently identified is an endogenous selective inhibitor of lymphangiogenesis. To evaluate the antimetastatic potential of esVEGFR-2, gene therapy with vector expressing esVEGFR-2 (pesVEGFR-2) or endostatin (pEndo) as a positive control was conducted on murine metastatic mammary cancer. Syngeneic inoculated metastatic mammary cancers received direct intratumoral injection of pesVEGFR-2, pEndo or pVec as control, once a week for six weeks. In vivo gene electrotransfer was performed on the tumors after each injection. Deaths from metastasis were much lower in the pesVEGFR-2 and pEndo groups than in those of the pVec. Tumor volume was significantly lower in the pesVEGFR-2 and the ...
Cancer metastasis contributes significantly to cancer mortality and is facilitated by lymphangiogenesis and angiogenesis. A new splicing variant, endogenous soluble vascular endothelial growth factor receptor-2 (esVEGFR-2) that we recently identified is an endogenous selective inhibitor of lymphangiogenesis. To evaluate the antimetastatic potential of esVEGFR-2, gene therapy with vector expressing esVEGFR-2 (pesVEGFR-2) or endostatin (pEndo) as a positive control was conducted on murine metastatic mammary cancer. Syngeneic inoculated metastatic mammary cancers received direct intratumoral injection of pesVEGFR-2, pEndo or pVec as control, once a week for six weeks. In vivo gene electrotransfer was performed on the tumors after each injection. Deaths from metastasis were much lower in the pesVEGFR-2 and pEndo groups than in those of the pVec. Tumor volume was significantly lower in the pesVEGFR-2 and the ...
BALB/c Mouse Lymphatic Endothelial Cells from Creative Bioarray are isolated from lymph node tissue of pathogen-free laboratory mice. BALB/c Mouse Lymphatic Endothelial Cells are grown in T25 tissue culture flasks pre-coated with gelatin-based coating solution for 2 min and incubated in Creative Bioarray Culture Complete Growth Medium generally for 3-7 days. Cultures are then expanded. Prior to shipping, cells are detached from flasks and immediately cryo-preserved in vials. Each vial contains at least 1x10^6 cells per ml and are delivered frozen. The method we use to isolate endothelial cells was developed based on a combination of established and our proprietary methods. These cells are pre-coated with LYVE1 antibody, following the application of magnetic beads pre-coated with secondary antibody ...
CD1 Mouse Dermal Lymphatic Endothelial Cells from Creative Bioarray are isolated from skin tissue of pathogen-free laboratory mice. CD1 Mouse Dermal Lymphatic Endothelial Cells are grown in T25 tissue culture flasks pre-coated with gelatin-based coating solution for 2 min and incubated in Creative Bioarray Culture Complete Growth Medium generally for 3-7 days. Cultures are then expanded. Prior to shipping, cells are detached from flasks and immediately cryo-preserved in vials. Each vial contains at least 1x10^6 cells per ml and are delivered frozen. The method we use to isolate endothelial cells was developed based on a combination of established and our proprietary methods. These cells are pre-coated with LYVE1 antibody, following the application of magnetic beads pre-coated with secondary antibody ...
We present an automated, label-free method for lymphangiography of cutaneous lymphatic vessels in humans in vivo using optical coherence tomography (OCT). This method corrects for the variation in OCT signal due to the confocal function and sensitivity fall-off of a spectral-domain OCT system and utilizes a single-scattering model to compensate for A-scan signal attenuation to enable reliable thresholding of lymphatic vessels. A segment-joining algorithm is then incorporated into the method to mitigate partial-volume effects with small vessels. The lymphatic vessel images are augmented with images of the blood vessel network, acquired from the speckle decorrelation with additional weighting to differentiate blood vessels from the observed high decorrelation in lymphatic vessels. We demonstrate the method with longitudinal scans of human burn scar patients undergoing ablative fractional laser treatment, showing the visualization of the ...
Humans and many other animals have a lymphatic system, which helps the body to fight disease. In this way the lymphatic system is a part of the immune system. The lymphatic system also carries fluid throughout the body. In this way it is a part of the circulatory system. Major parts of the lymphatic system include the lymphatic vessels, the lymph nodes, and cells called lymphocytes. The spleen, the tonsils, the appendix, bone marrow, and…
VEGFC - VEGFC (Myc-DDK-tagged)-Human vascular endothelial growth factor C (VEGFC) available for purchase from OriGene - Your Gene Company.
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Lymph node metastasis is considered a factor in determining the prognosis of squamous cell carcinoma (SCC). Both oral and cervical SCC tumor cells prefer lymph vessels as the route of metastasis. D2-40 is a specific marker of lymphatic endothelial cells. This study clarifies the distribution and characteristics of lymphatic vessels in oral and cervical SCCs. Immunohistochemistry was performed in 20 oral and 20 cervical SCCs (10 non-metastatic and 10 metastatic to lymph nodes) using D2-40, CD31, CD34, CD105 and double staining with D2-40 and keratin. Lymphatic vessel density (LVD) was also determined morphologically. Results showed that lymphatic vessels in both types of SCCs were distributed mainly at the superficial region beneath the epithelium. The LVD in each tumor was significantly higher compared to the corresponding normal mucosa. Moreover, the LVD in lymph node ...
Signs of Lymphatic system cancer including medical signs and symptoms of Lymphatic system cancer, symptoms, misdiagnosis, tests, common medical issues, duration, and the correct diagnosis for Lymphatic system cancer signs or Lymphatic system cancer symptoms.
Definition of lymphatic system in the Definitions.net dictionary. Meaning of lymphatic system. What does lymphatic system mean? Information and translations of lymphatic system in the most comprehensive dictionary definitions resource on the web.
BACKGROUND Lymphedema is a chronic peripheral swelling caused by a dysfunction of the lymphatic system, leading to discomfort and loss of upper limb movement. Therapies to treat or manage this swelling have limited evidence, partly because of a paucity in objective lymphatic measures. This study explored the role of near-infrared (NIR) imaging in evaluating interventions. METHODS Nine healthy volunteers underwent NIR fluoroscopy using a microdose (50 μL, 0.05% w/v) of indocyanine green to quantify lymphatic behavior before and after a 15-minute period of manual lymph drainage followed by compression garment (CG) therapy for a 10-minute period. Images were taken at the forearm and elbow after each intervention. Lymphatic function was defined by the number, size, displacement, and speed of lymph packets. The lymph parameters were analyzed to assess the effects of the interventions compared with basal values. RESULTS Baseline (BL) ...
With the hope of finding markers that may enable more targeted therapy, the researchers studied samples obtained from 15 patients with thyroid eye disease undergoing orbital decompression. In samples from the acute, inflammatory stage of the disease, they found that both rare lymphatic vessels and robust blood vessels had formed.. While more studies are needed, the proliferation of leaky blood vessels not only offers an underlying mechanism for the swelling, but also offers the potential to be controlled with local administration of angiogenesis inhibitors (such as anti-VEGF). Moreover, by determining the mechanisms underlying lymphatic vessel formation in the acute stage of the disease, the creation of functional lymphatic vessels may be utilized as a therapeutic option to better drain fluid from the orbit.. This exciting study gives us some new insights into how we might get to the root cause of this devastating disease and better manage it through less ...
New lymphatic imaging technologies are needed to better assess immune function and cancer progression and treatment. Lymphatic uptake depends mainly on particle size (10-100 nm) and charge. The size of carriers for imaging and drug delivery can be optimized to maximize lymphatic uptake, localize chemotherapy to lymphatic metastases, and enable visualization of treatment deposition. Toward this end, female BALB/c mice were injected subcutaneously in the hind footpad or forearm with a series of six different molecular weight hyaluronan (HA) near-infrared dye (HA-IR820) conjugates (ca. 5-200 nm). Mice were imaged using whole body fluorescent imaging over two weeks. HA-IR820 fluorescence was clearly visualized in the draining lymphatic capillaries, and in the popliteal and iliac or axillary lymph nodes. The 74-kDa HA-IR820 had the largest lymph node area-under-the-curve. In contrast to prior reports, mice bearing limb tumors ...
The lymphatic endothelial receptor LYVE-1 has been implicated in both uptake of hyaluronan (HA) from tissue matrix and in facilitating transit of leukocytes and tumor cells through lymphatic vessels based largely onin vitrostudies with recombinant receptor in transfected fibroblasts. Curiously, however, LYVE-1 in lymphatic endothelium displays little if any binding to HAin vitro, and this has led to the conclusion that the native receptor is functionally silenced, a feature that is difficult to reconcile with its proposedin vivofunctions. Nonetheless, as we reported recently, LYVE-1 can function as a receptor for HA-encapsulated Group A streptococci and mediate lymphatic dissemination in mice. Here we resolve these paradoxical findings and show that the capacity of LYVE-1 to bind HA is strictly dependent on avidity, demanding appropriate receptor self-association and/or HA multimerization. In particular, we demonstrate the prerequisite of a ...
Weight loss occurs naturally as the body gets healthier by killing the candida off,. the toxic load on the lymphatic system causes the body to hold water.Vibration exercise machines improve your lymphatic health. Vibration exercise machines improve your lymphatic health. Thursday,. is weight loss.. A few common myths about cellulite: It can be diet or exercised away.How To Detox The Lymphatic System Weight Loss And Garcinia Cambogia Price Of Pure Garcinia Slim How To Detox The Lymphatic System Garcinia Cambogia Top Secret Brand ...
Background: Scientific understanding of the role of VEGF-A in tumor angiogenesis has led to the development of antiangiogenic therapies, such as bevacizumab, that selectively target VEGF-A. However, clinical trials across multiple cancer types have resulted in limited positive outcomes. VEGF-C is thought to be a potent lymphangiogenic growth factor and plays a role in tumor angiogenesis through VEGFR3; it has also been shown to bind to VEGFR2, which is important in tumor angiogenesis. Nevertheless, a direct role of VEGF-C in driving tumor angiogenesis has not been established.. To explore the potential of VEGF-C as a driver of tumor angiogenesis and its implication in developing antiangiogenic therapies, we assessed the activity of tivozanib, a potent and selective TKI for VEGFR1, 2 and 3, and a VEGF-A targeted antibody in animal tumor models that exhibit distinct VEGF-C and VEGF-A expression.. Method: A total of 107 independently derived murine breast tumors were expanded in vivo to establish ...
The lymphatic system is a system in the body that is created to remove the cellular waste from the body. In addition, it also plays an important role in the immune system. Lymph vessels are the main component in the lymphatic system and these vessels transfer the lymph fluid from extremities to the lymph ducts where after a short period of time they are left in the veins and mix with blood.. This system is not triggered by some pump (like the blood system). It uses muscle contractions to move around the body. Lymph nodes are another important part of this system. These nodes are essential part of the immune system and they locate, capture and process toxins and other harmful particles.. In cases of infection, the lymph nodes usually become swollen because the body "automatically" transfers back bacteria to the nodes where they need to be eliminated with the help of white blood cells.. In addition, the lymphatic system is not only a system responsible for ...
Synonyms for anterior cardinal vein in Free Thesaurus. Antonyms for anterior cardinal vein. 1 word related to anterior cardinal vein: cardinal vein. What are synonyms for anterior cardinal vein?
My goals are to understand the molecular mechanisms regulating lymphatic and valvular endothelial cell development and maintenance.. The mammalian lymphatic vasculature is important for returning the extravasated plasma fluids in tissue space back to blood circulation, absorption of digested lipids from the intestine and in immune surveillance. Lymphedema is a disfiguring and mobility restricting disease that results due to the abnormal functioning of the lymphatic vasculature. Lymphedema is a common disorder that results either due to mutations in genes that regulate lymphatic vascular development or more often due to infection or surgical damage to the lymphatic vessels. Lymphatic vasculature is also considered as a major route for tumor metastasis especially melanoma and breast cancer. Despite its importance, diagnosis of lymphatic disorders and the ...
The major causes of lymphatic congestion. Even though there are many factors which can contribute the lymphatic system and lymph nodes to become congested, these factors are considered as the main causes:. Stress. In more than 80% of chronic health issues, stress has been considered as the main cause. The chemistry of stress is lymph congesting and degenerative.. Digestive imbalances. They can irritate intestinal villi, the main reason for lymph congestion. The fact that the majority of the lymph in the body surrounds the gut indicates that the quality of the villi is essential for proper lymph flow, assimilation, immunity, and detoxification.. Iodine deficiency. This is also a common cause of lymphatic congestion. Iodine supports the lymphatic system at the cellular level and helps to mitigate the effects of a toxic environment.. Constricting clothings can impede normal lymphatic flow. One of the largest clusters of lymph ...
The health of our lymphatic system is directly related to the power of our immune system. There are many simple things we can do to enhance lymphatic function. This, in turn, will help fortify our immune system and strengthen our resistance to breast cancer. - The Lymphatic System and Breast Cancer - Breast Cancer at BellaOnline
Vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) are key drivers of blood and lymph vessel formation in development, but also in several pathological processes. VEGF-C signaling through VEGFR-3 promotes lymphangiogenesis, which is a clinically relevant target for treating lymphatic insufficiency and for blocking tumor angiogenesis and metastasis. The extracellular domain of VEGFRs consists of seven Ig homology domains; domains 1-3 (D1-3) are responsible for ligand binding, and the membrane-proximal domains 4-7 (D4-7) are involved in structural rearrangements essential for receptor dimerization and activation. Here we analyzed the crystal structures of VEGF-C in complex with VEGFR-3 domains D1-2 and of the VEGFR-3 D4-5 homodimer. The structures revealed a conserved ligand-binding interface in D2 and a unique mechanism for VEGFR dimerization and activation, with homotypic interactions in D5. Mutation of the conserved ...
Patent blue-enhanced lymphaticovenular anastomosis. Dec 2012 Ayestaray B, Bekara F, Andreoletti JB. Source Department of Plastic and Reconstructive Surgery, Nimes University Hospital, pl Pr Robert Debré, 30000 Nimes, France; Department of Plastic and Reconstructive Surgery, Breast Institute, 15 Av. Jean Jaurès, 90000 Belfort, France. Electronic address: [email protected] Abstract Keywords: Lymphedema, Supermicrosurgery, Patent blue, Lymphatic vessel, Lymphaticovenular anastomosis BACKGROUND: Lymphoedema supermicrosurgery is known to be difficult to perform. Lymphatic vessels are not easy to individualise, because of their small calibre (inferior to 1 mm) and their translucent appearance. Patent blue is an organic colourant, which is able to enhance the lymphatic network. We have evaluated the morbidity and the efficacy of patent blue lymphatic enhancement, with a view to perform ...
Artwork illustrating the human lymphatic system, a network of vessels that carries lymph (water, proteins, electrolytes) from the tissue fluids to the bloodstream. At intervals along the length of lymphatic vessels are swellings (nodes); groups of nodes are found in the groin, neck, armpit and behind the ear. The nodes function to filter lymph through the action of scavenging macrophages & prevent foreign particles from entering the bloodstream. They are also sites of storage & proliferation of both B- and T-lymphocytes, white blood cells involved in the immune response to infection. - Stock Image P290/0005
What are the responsiblities of the lymphatic system?. Our lymphatic system helps with immune function and circulation, carrying lymphatic fluid waste products to the lymph nodes to be broken down and sent out of the body (usually through urine output), while the rest of the protein-rich fluid is sent back into our circulatory system.. Our lymphatic system covers our entire body alongside our circulatory system. The lymph nodes lay in chains along the lymphatic vessels throughout our body. The main areas include the neck, armpits and groin region. Were not born with a set number of lymph nodes, so you can have 25 under one armpit and just five under the other. When our lymph nodes are removed or damaged, they dont regrow and they dont repair themselves. When the transport capacity of the lymphatic system is not functioning at 100 percent, the body will do as much as it can to maintain balance and keep things ...
Circulatory system. General outline. Heart Arteries Capillaries veins. Blood vascular system. Lymphatic capillaries Lymphatic vessel Lymphatic ducts. Lymphatic vascular system. Capillaries . A single layer of endothelial cells basement membrane A few connective tissue (pericytes). Slideshow...
Lymphatic vessels stem from preexisting blood vessels. Elegant lineage tracing by Srinivasan et al. (2007) demonstrated the venous origin of the mammalian lymphatic vasculature as previously proposed (Sabin, 1902; Kaipainen et al., 1995). The venous origin of LECs has been confirmed in Xenopus laevis and zebrafish as shown by real-time imaging in the latter and, therefore, appears to be evolutionary conserved (Ny et al., 2005; Yaniv et al., 2006; Hogan et al., 2009a).. In mice, LECs are first specified in the anterior cardinal vein around embryonic day 9.5 (E9.5) when a subset of venous endothelial cells expresses the transcription factor Prox1 and the lymphatic vessel hyaluronan receptor-1 (LYVE-1) in a polar manner (Fig. 2 B). Prox1−/− mice do not develop any lymphatic structures because of failed budding and sprouting of LECs (Wigle and Oliver, 1999). The transcription factor Sox18 induces Prox1 expression, and Sox18−/− mice develop edema ...
To induce adaptive immunity, dendritic cells (DCs) migrate through afferent lymphatic vessels (LVs) to draining lymph nodes (dLNs). This process occurs in several consecutive steps. Upon entry into lymphatic capillaries, DCs first actively crawl into downstream collecting vessels. From there, they are next passively and rapidly transported to the dLN by lymph flow. Here, we describe a role for the chemokine CCL21 in intralymphatic DC crawling. Performing time-lapse imaging in murine skin, we found that blockade of CCL21-but not the absence of lymph flow-completely abolished DC migration from capillaries toward collecting vessels and reduced the ability of intralymphatic DCs to emigrate from skin. Moreover, we found that in vitro low laminar flow established a CCL21 gradient along lymphatic endothelial monolayers, thereby inducing downstream-directed DC migration. These findings reveal a role for ...
Phthiocerol dimycocerosates (PDIM), glycolipids found on the outer surface of virulent members of the Mycobacterium tuberculosis (Mtb) complex, are a major contributing factor to the pathogenesis of Mtb. Myelocytic cells, such as macrophages and dendritic cells, are the primary hosts for Mtb after infection and previous studies have shown multiple roles for PDIM in supporting Mtb in these cells. However, Mtb can infect other cell types. We previously showed that Mtb efficiently replicates in human lymphatic endothelial cells (hLECs) and that the hLEC cytosol acts as a reservoir for Mtb in humans. Here, we examined the role of PDIM in Mtb translocation to the cytosol in hLECs. Analysis of a Mtb mutant unable to produce PDIM showed less co-localisation of bacteria with the membrane damage marker Galectin-8 (Gal8), indicating that PDIM strongly contribute to phagosomal membrane damage. Lack of this Mtb lipid also leads to a reduction in the proportion of Mtb co-localising with markers of ...
Vascular endothelial growth factor (VEGF) was originally identified as an endothelial cell specific growth factor stimulating angiogenesis and vascular permeability. Some family members, VEGF C and D, are specifically involved in lymphangiogenesis. It now appears that VEGF also has autocrine functions acting as a survival factor for tumour cells protecting them from stresses such as hypoxia, chemotherapy and radiotherapy. The mechanisms of action of VEGF are still being investigated with emerging insights into overlapping pathways and cross-talk between other receptors such as the neuropilins which were not previously associated with angiogenesis. VEGF plays an important role in embryonic development and angiogenesis during wound healing and menstrual cycle in the healthy adult. VEGF is also important in a number of both malignant and non-malignant pathologies. As it plays a limited role in normal human physiology, VEGF is an attractive therapeutic target in diseases where VEGF plays a key ...
TY - JOUR. T1 - Keratinization and necrosis. T2 - Morphologic aspects of lymphatic metastases in ultrasound. AU - Mäurer, Jürgen. AU - Willam, Carston. AU - Steinkamp, Herrmann J.. AU - Knollmann, Friedrich D. AU - Felix, Roland. PY - 1996/9. Y1 - 1996/9. N2 - RATIONALE AND OBJECTIVES. The authors performed a retrospective study in ultrasound to investigate new aspects in the sonomorphology of lymph node metastases of the neck. In this study, it could be demonstrated the first time that the histologic characteristics of the metastases determine the sohographic appearance. In addition to criteria such as the longitudinal/transversal quotient, sonomorphology could support a more precise differential diagnosis of neck lymph nodes. METHODS. In 105 of 145 patients with histologically proved head and neck carcinomas, 187 lymph node metastases were detected by ultrasound. Sohomorphology was compared with the corresponding histology. RESULTS. Five sohomorphologic groups could be differentiated. (1) ...
Metastatic potential. Tumor angiogenesis is closely related to lymphangiogenesis in the spread of cancer cells from the primary neoplasm to other tissues and organs and usually first occur via the sentinel lymph node.36 Nevertheless, melanoma tumor cells can bypass the lymph-node system and metastasize to distant organs by gaining direct access to blood circulation. Depending on the angiogenic potential of the tumor cells trapped in secondary organ capillary beds, metastatic tumor growth can be favored by increased induction of neovascularization.37 Some authors therefore suggest that tumor angiogenesis is associated with poor prognostic outcome and increased rate of relapse in melanoma.38-40 Pro-angiogenic factors such as VEGF-A, IL-8, PDEGF, bFGF, Ang-2 and MMP, necessary for tumor angiogenesis can be generated in part by melanoma cells.41,42 Therefore, the clinical utility of VEGF serum determination in melanoma patients has been under investigation as circulating serum levels of VEGF in ...
platelet-derived growth factor C: member of PDGF/VEGF family of growth factors; ligand for PDGF-alpha receptor; amino acid sequence in first source; RefSeq NM_016205 (human), NM_019971 (mouse), NM_031317 (rat)
3. Exercise. The lymphatic system works best when you move your body, which helps keep fluids circulating and nutrients reaching your cells. Theres a reason why being stagnant causes you to feel more achy, stiff and prone to becoming sick.. Any type of regular exercise and movement (such as simply walking more) is good for keeping lymph fluid flowing, but some exercise seems to be particularly beneficial, including yoga (which twists the body and helps fluid drain), high-intensity interval training (also called HIIT workouts, which is great for improving circulation) or "rebounding.". Rebounding is growing in popularity and involves jumping a small trampoline that you can keep inside your house. It only takes up a few feet, and just five to 10 minutes of jumping daily can really get your heart rate up and help keep your lymphatic system running smoothly.. (And why not follow up exercise with a relaxing detox bath to further help improve blood flow?). 4. Massage Therapy and ...
A healthy lymphatic system is key to your health and is especially important for the health of your eyes and skin. The lymphatic system is your bodys built-in sanitation system-the plumbing that carries away and filters out carcinogens and toxins from every cell, tissue and organ in the human body. The lymphatic system also plays an extremely important role in having a strong immune system. Think of your lymphatic system as the street cleaner and garbage collector for the human body. Unlike the heart which pumps our blood, the Lymphatic System has no pump so it needs help in moving fluid throughout the body. The lymphatic system is made up of:. ...
There have been several questions on our Lymphedema forum asking about the surgical treatment options for lymphedema so I decided to provide a general discussion of the surgical management of lymphedema. The are several different surgical approaches to the treatment of lymphedema. For the sake of simplicity, most of the techniques involve the formation of an anastamosis between the lymphatic system and the venous system. An anastamosis is essentially a bridge or conduit from the lymphatic system to the venous system. The goal of these microvascular surgeries is to form a channel between the pooled and blocked lymphatic system and the venous system so that the venous system can remove the accumulated lymphatic fluid. A brief review the physiology of the lymphatic system is in order to help understand these surgical techniques. Arterial, or oxygenated blood is pumped from the heart to the various tissues. The oxygen is removed ...
Chapter 13 Learning Outcomes Section 1: Anatomy of the Lymphatic System 13.1 Describe the structure and function of important lymphatic vessels, their relationship to blood vessels, and how lymph flows in the body Describe the lymph collecting vessels, identify the structures returning lymph to the venous system, and explain lymphedema Define lymphopoiesis, and discuss the classes of lymphocytes, their importance, and their distribution in the body Identify and describe lymphoid tissues and lymphoid organs, and trace the pathway of lymph flow through a lymph node. © 2013 Pearson Education, Inc.
The most common type of lymphoma is called Hodgkins disease. All other lymphomas are grouped together and are called non-Hodgkins lymphomas.…..CLICK & SEE. The lymphatic system is part of the bodys immune defense system. Its job is to help fight diseases and infection.. The lymphatic system includes a network of thin tubes that branch, like blood vessels, into tissues throughout the body. Lymphatic vessels carry lymph, a colorless watery fluid that contains infection-fighting cells called lymphocytes. Along this network of vessels are groups of small, bean-shaped organs called lymph nodes. Clusters of lymph nodes are found in the underarms, groin, neck, chest, and abdomen.. Other parts of the lymphatic system are the spleen, thymus, tonsils, and bone marrow. Lymphatic tissue also is found in other parts of the body, including the stomach, intestines, and skin.. Non-Hodgkins lymphoma, also called non-Hodgkin lymphoma, is ...
The Lymphatic System. Lymph nodes are part of the lymphatic system, which is a network of tiny tubes that carry a colourless fluid called lymph through the skin and deeper parts of the body. Lymph fluid contains immune cells (lymphocytes) nutrients and waste materials.. Lymphatic Vessels. It bathes the cells of the skin and internal organs and drains into lymphatic vessels then larger ducts in the neck before joining the blood stream near the heart (see Figure 1).. Lymph Nodes. Lymph nodes (glands) are small oval nodules and contain millions of infections fighting lymphocyte cells. They are found at intervals along the lymphatic vessels like beads on a string (see Diagram 1). The lymph nodes filter out harmful organisms and abnormal cells before the lymph reaches the blood stream. Lymph nodes can only be felt in certain areas:. ...
The lymphatic system also helps defend the body against germs (viruses, bacteria, and fungi) that can cause illnesses. Those germs are filtered out in the lymph nodes, small clumps of tissue along the network of lymph vessels. Inside the lymph nodes, lymphocytes called T-cells and B-cells help the body fight infection. B cells make antibodies - special proteins that stop infections from spreading by trapping disease-causing germs and destroying them.. Most of our lymph nodes are in clusters in the neck, armpit, and groin area. Theyre also found along the lymphatic pathways in the chest, abdomen, and pelvis, where they filter the blood.. When a person has an infection, germs collect in the lymph nodes. If the throat is infected, for example, the lymph nodes in the neck may swell. Thats why doctors check for swollen lymph nodes (sometimes called swollen glands) in the neck when someone has a sore throat. This is called lymphadenopathy.. Reviewed by: Larissa Hirsch, ...
Cancer, or cancer treatments, can cause damage to the lymphatic system. Cancer itself can get in the way of fluid draining out of the extremity. The treatments for cancer, particularly surgery and radiation, can damage lymphatic vessels and lymph nodes. While lymphatic vessels will grow again given time and a good healing environment, lymph nodes are not able to regrow.. Chemotherapy does not cause lymphedema, but can contribute to the swelling as it causes some water retention throughout the whole body. I would like to stress that while the treatments for cancer can cause lymphedema, those treatments were chosen to increase your chances of survival. Lymphedema is not a life-threatening disease, but cancer is. Those providing your cancer treatments have and/or will provide it in such a way to reduce your chance of getting lymphedema and still maximize your chance of survival.. Lymphedema can affect people soon after surgery and/or radiation, or 20 years down ...
To learn about the benefits of manual lymphatic drainage in New York City and the important role of your lymphatic system, call VitalGate Health today.
It is an important system to say the least, but it once we learned how to monitor it, the lymphatic system became an important tool in diagnostic medicine. Basically, the lymphatic system will become inflamed during infection or injury. Doctors, then, can detect this inflammation to help determine illness.. Soft nodes, for example, can mean a simple infection while multiple "buckshot" size nodes could be an indication of viral infection. Rock hard nodes, though, may be a sign of some types of metastatic cancer. Of course, firm-but rubbery-lymph nodes could be a sign of lymphoma.. But while our understanding of the lymphatic system helps medical professionals to more effectively diagnose and treat disease, this understanding is also the basis of a modality of massage called, fittingly, lymphatic massage.. The lymph nodes are located all over the body. Yes, there are some in the throat but u can also find them under the armpit, behind the ...
The lymphatic system is comprised of vessels, nodes and organs. It plays an important role in maintaining stasis in the circulatory system, supplying white blood cells to fight infection and disease and removing metabolic waste products. At the cellular level in the interstitial space between arteriole and venous ends, tiny lymphatic capillaries collect, filter and absorb the remains of plasma and by-products of cellular activity and store them as lymph fluid. Most of the interstitial fluid is reabsorbed into the venous blood stream; the remainder is taken up by lymph. When there is a lymphatic blockage or dysfunction, excess fluid cannot drain effectively. The result is edema or swelling due to fluid retention or build-up. Localized swelling is common with soft tissue injuries.. The lymphatic system begins with tiny capillaries that increase in size to deeper vessels or collectors (nodes). The largest lymph vessels are called ducts and they ...
Vanishing Veins sclerotherapy service treating varicose and thread veins provided by French Phlebologist working from Holbrook Surgery Horsham West Sussex UK non-surgical procedures artery and lymphatic system specialists.
Lymphatic vessels have several similarities to veins. Both are thin walled and return fluid to the right hand side of the heart. The movement of the fluid in both is brought about by the contraction of the muscles that surround them and both have valves to prevent backflow. One important difference is that lymph passes through at least one lymph node or gland before it reaches the blood system (see diagram 10.2). These filter out used cell parts, cancer cells and bacteria and help defend the body from infection.. Lymph nodes are of various sizes and shapes and found throughout the body and the more important ones are shown in diagram 10.3. They consist of lymph tissue surrounded by a fibrous sheath. Lymph flows into them through a number of incoming vessels. It then trickles through small channels where white cells called macrophages (derived from monocytes) remove the bacteria and debris by engulfing and digesting them (see diagram 10.4). The lymph then leaves the lymph nodes through ...
It will decrease swelling and speed healing, pregnant women to help deal with the common problem of swollen feet, and of course anyone with a lymphatic system dysfunction," Wdowiak said.. This includes lymphedema, a condition that can cause swelling in the arm or legs. You can be born with it, she adds, or acquire it if you undergo lymph node removal.. "All combined decongestive therapists have specific training in how to work with cancer patients and survivors who are dealing with lymphedema, due to removal of lymph nodes or severing of lymphatic vessels.". When it comes to people at risk, Wdowiak says this can include someone who already has a severe liver condition or unregulated high blood pressure.. "The technique will slightly increase blood volume and push more toxins through the liver to process," she said.. ...
Circulating tumor cells (CTC) released from primary tumor tissues into bloodstream or lymphatic vessels are emerging as novel tools in the detection and prognosis of several types of metastatic cancers. At present, CTC markers are limited to epithelial cancers and there are no specific markers available to detect mesenchymal and epithelial-mesenchymal transformed (EMT) CTCs. EMT cells are characterized by increased motility and invasiveness and are known to escape detection technologies that use EpCAM and cytokeratins as CTC markers. Here we report a novel antibody, 84-1 for detection of mesenchymal and EMT CTC. Antibodies were raised in mice after injecting metastatic cancer cells and clones were selected that were positive only for CTC and negative for PBMCs and normal cells. 84-1 was the only antibody that was unique in its ability to detect CTCs from mesenchymal tumors and EMT CTC from epithelial tumors. Studies for characterization of the epitope for 84-1 antibody are ongoing. We then ...
Choose one of the three main types of lymphocytes - B-cells, T-cells or Natural Killer cells- and describe a function it has in the body.. 2. How does the lymphatic system contribute to the bodys defenses?. 3. Identify the components and anatomy of the lymphatic system. 4. Discuss the role of the innate immune response against pathogens. 5. Describe the power of the adaptive immune response to cure disease. 6. Explain immunological deficiencies and over-reactions of the immune system. 7. Discuss the role of the immune response in transplantation and cancer. 8. Describe the interaction of the immune and lymphatic systems with other body systems. ...

Rapamycin, a specific inhibitor of the mammalian target of rapamycin, suppresses lymphangiogenesis and lymphatic metastasis.  -...Rapamycin, a specific inhibitor of the mammalian target of rapamycin, suppresses lymphangiogenesis and lymphatic metastasis. -...

VEGF-C has recently been identified as a key molecule that involved in tumor lymphangiogenesis and lymphatic metastasis. ... Rapamycin, a specific inhibitor of the mammalian target of rapamycin, suppresses lymphangiogenesis and lymphatic metastasis.. ... Rapamycin, a specific inhibitor of the mammalian target of rapamycin, suppresses lymphangiogenesis and lymphatic metastasis. [ ... Tumor lymphangiogenesis is now known to play a causal role in lymph node metastasis, and thus its inhibition would have great ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/17425689?dopt=Abstract

Vascular endothelial growth factor-D induces lymphangiogenesis and lymphatic metastasis in models of ductal pancreatic cancer. ...Vascular endothelial growth factor-D induces lymphangiogenesis and lymphatic metastasis in models of ductal pancreatic cancer. ...

Our results suggest that VEGF-D plays a pivotal role in stimulating lymphangiogenesis and lymphatic metastasis in human ductal ... We further addressed the biological function of VEGF-D for induction of lymphatic metastasis in a nude mouse xenograft model ... In order to better understand the mechanisms controlling lymphatic growth and lymph node metastasis in human ductal pancreatic ... with a significant increase in lymphatic vessel invasion by tumor cells and an increased rate of lymphatic metastases, as ...
more infohttps://www.imm.ox.ac.uk/publications/102731

PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis. - Radcliffe Department of MedicinePDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis. - Radcliffe Department of Medicine

... blockage of PDGF-induced lymphangiogenesis may provide a novel approach for prevention and treatment of lymphatic metastasis. ... Expression of PDGF-BB in murine fibrosarcoma cells induced tumor lymphangiogenesis, leading to enhanced metastasis in lymph ... These data demonstrate that PDGF-BB is an important growth factor contributing to lymphatic metastasis. Thus, ... In vitro, PDGF-BB stimulated MAP kinase activity and cell motility of isolated lymphatic endothelial cells. In vivo, PDGF-BB ...
more infohttps://www.rdm.ox.ac.uk/publications/102739

PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis (vol 6, pg 333, 2004) - Radcliffe Department...PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis (vol 6, pg 333, 2004) - Radcliffe Department...

PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis (vol 6, pg 333, 2004) ... PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis (vol 6, pg 333, 2004) ... PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis (vol 6, pg 333, 2004) ...
more infohttps://www.rdm.ox.ac.uk/publications/102727

S1PR1 on tumor-associated macrophages promotes lymphangiogenesis and metastasis via NLRP3/IL-1β | JEMS1PR1 on tumor-associated macrophages promotes lymphangiogenesis and metastasis via NLRP3/IL-1β | JEM

Lymphangiogenesis and lymphatic metastasis in breast cancer. Pathophysiology. 17:229-251. doi:10.1016/j.pathophys.2009.11.003. ... indicating dysfunctional lymphangiogenesis (Fig. 3, A and B). Lymphangiogenesis contributes to carcinoma metastasis in various ... Lymphangiogenesis and lymphatic vessel remodelling in cancer. Nat. Rev. Cancer. 14:159-172. doi:10.1038/nrc3677. ... TAMs infiltrating mouse breast tumors prevents pulmonary metastasis and tumor lymphangiogenesis. Reduced lymphangiogenesis was ...
more infohttp://jem.rupress.org/content/214/9/2695

High scavenger receptor class B type I expression is related to tumor aggressiveness and poor prognosis in breast cancer |...High scavenger receptor class B type I expression is related to tumor aggressiveness and poor prognosis in breast cancer |...

Endothelial nitric oxide synthase mediates lymphangiogenesis and lymphatic metastasis. Cancer Res. 2009;69(7):2801-8.CrossRef ... Nitric oxide in breast cancer: induction of vascular endothelial growth factor-C and correlation with metastasis and poor ... Hypochlorite-induced oxidative stress elevates the capability of HDL in promoting breast cancer metastasis. J Transl Med. 2012; ... lymph node metastasis (P = 0.012), and the absence of ER (P = 0.014). The Kaplan-Meier survival analysis revealed that patients ...
more infohttps://link.springer.com/article/10.1007%2Fs13277-015-4141-4

Basement membrane protein distribution in LYVE-1-immunoreactive lymphatic vessels of normal tissues and ovarian carcinomas |...Basement membrane protein distribution in LYVE-1-immunoreactive lymphatic vessels of normal tissues and ovarian carcinomas |...

Cao Y (2005) Opinion: emerging mechanisms of tumour lymphangiogenesis and lymphatic metastasis. Nat Rev Cancer 5:735-743PubMed ... Ji RC (2006) Lymphatic endothelial cells, lymphangiogenesis, and extracellular matrix. Lymphat Res Biol 4:83-100PubMedCrossRef ... Ayhan A, Gultekin M, Taskiran C, Celik NY, Usubutun A, Kucukali T, Yuce K (2005) Lymphatic metastasis in epithelial ovarian ... The localization of basement membrane proteins adjacent to lymphatic endothelia suggests a role for these proteins in lymphatic ...
more infohttps://link.springer.com/article/10.1007%2Fs00441-006-0366-2

TLR agonists regulate PDGF-B production and cell proliferation through TGF-beta/type I IFN crosstalk. - Semantic ScholarTLR agonists regulate PDGF-B production and cell proliferation through TGF-beta/type I IFN crosstalk. - Semantic Scholar

... a growth factor implicated in a number of diseases ranging from tumor metastasis to glomerulonephritis. We demonstrate that CpG ... PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis.. *Renhai Cao, Meit A Björndahl, +10 authors ...
more infohttps://www.semanticscholar.org/paper/TLR-agonists-regulate-PDGF-B-production-and-cell-I-Chow-O%27connell/74d083352990a47f0e3f03ba83fedf0a585fd852

Importance of lymph vessels in gastric cancer: a prognostic indicator in general and a predictor for lymph node metastasis in...Importance of lymph vessels in gastric cancer: a prognostic indicator in general and a predictor for lymph node metastasis in...

Recent evidence suggests that tumour lymphangiogenesis promotes lymphatic metastasis.. Aims: To study the role of lymph vessel ... Background: Metastasis to regional lymph nodes (LNs) through lymphatic vessels is common in cancer progression and is an ... LVD significantly correlated with LN metastasis at surgery and podoplanin positive lymphatic invasion. In multivariate analysis ... Methods: Lymphatics of 117 primary human gastric cancer cases were investigated by quantitative immunohistochemical staining ...
more infohttp://jcp.bmj.com/content/59/1/77

Frontiers | The Crohns-Like Lymphoid Reaction to Colorectal Cancer-Tertiary Lymphoid Structures With Immunologic and...Frontiers | The Crohn's-Like Lymphoid Reaction to Colorectal Cancer-Tertiary Lymphoid Structures With Immunologic and...

Li S, Li Q. Cancer stem cells, lymphangiogenesis, and lymphatic metastasis. Cancer Lett. (2015) 357:438-47. doi: 10.1016/j. ... Molecular mechanisms of lymphatic metastasis in solid tumors of the gastrointestinal tract. Int J Clin Exp Pathol. (2012) 5:614 ... Molecular control of lymphatic metastasis. Ann N Y Acad Sci. (2008) 1131:225-34. doi: 10.1196/annals.1413.020 ... The abundance of Tregs within TDLN is associated with lymphatic metastasis (72), akin to the evidence discussed above regarding ...
more infohttps://www.frontiersin.org/articles/10.3389/fimmu.2019.01884/full

Frontiers | WMJ-S-001, a Novel Aliphatic Hydroxamate-Based Compound, Suppresses Lymphangiogenesis Through p38mapk-p53-survivin...Frontiers | WMJ-S-001, a Novel Aliphatic Hydroxamate-Based Compound, Suppresses Lymphangiogenesis Through p38mapk-p53-survivin...

... these results indicate that WMJ-S-001 may inhibit lymphatic endothelial remodeling and suppress lymphangiogenesis through the ... However, whether WMJ-S-001 is capable of suppressing lymphangiogenesis remains unclear. We are thus interested in exploring WMJ ... However, whether WMJ-S-001 is capable of suppressing lymphangiogenesis and its underlying mechanisms remain unclear. In this ... 001s anti-lymphangiogenic mechanisms in lymphatic endothelial cell (LECs).Experimental approach: WMJ-S-001s effects on LEC ...
more infohttps://www.frontiersin.org/articles/10.3389/fonc.2019.01188/full

The AMEDEO Literature GuideThe AMEDEO Literature Guide

OxLDL promotes lymphangiogenesis and lymphatic metastasis in gastric cancer by upregulating VEGFC expression and secretion.. ... Long noncoding RNA H19 regulates cell growth and metastasis via the miR223p/Snail1 axis in gastric cancer.. Int J Oncol. 2019; ... MicroRNA-379 inhibits metastasis and epithelial-mesenchymal transition via targeting FAK/AKT signaling in gastric cancer.. Int ... Enhanced expression of alpha2,3-linked sialic acids promotes gastric cancer cell metastasis and correlates with poor prognosis. ...
more infohttps://amedeo.com/medicine/gca/intjonc.htm

DiVA - Search resultDiVA - Search result

Interplay between various lymphangiogenic factors in promoting lymphangiogenesis and lymphatic metastasis remains poorly ... including promotion of lymphatic metastasis by modulating arterial-lymphatic conduits, in the mammalian system. ... Collaborative interplay between FGF-2 and VEGF-C promotes lymphangiogenesis and metastasis2012In: Proceedings of the National ... Nitric oxide permits hypoxia-induced lymphatic perfusion by controlling arterial-lymphatic conduits in zebrafish and glass ...
more infohttp://liu.diva-portal.org/smash/resultList.jsf?af=%5B%5D&aq=%5B%5B%7B%22journalId%22%3A%2215041%22%7D%5D%5D&aqe=%5B%5D&aq2=%5B%5B%5D%5D&language=en&query=

nature.com searchnature.com search

Cervical squamous cell carcinoma-secreted exosomal miR-221-3p promotes lymphangiogenesis and lymphatic metastasis by targeting ... for article Cervical squamous cell carcinoma-secreted exosomal miR-221-3p promotes lymphangiogenesis and lymphatic metastasis ... MicroRNA-221-3p, a TWIST2 target, promotes cervical cancer metastasis by directly targeting THBS2 *Wen-Fei Wei ... Rights & permissionsfor article MicroRNA-221-3p, a TWIST2 target, promotes cervical cancer metastasis by directly targeting ...
more infohttps://www.nature.com/search?author=%22Ming%20Yan%22&error=cookies_not_supported&code=f45025a9-af4c-494b-9ba0-fae3d0fe0a3c

Clinicopathological significance of platelet-derived growth factor (PDGF)-B and vascular endothelial growth factor-A expression...Clinicopathological significance of platelet-derived growth factor (PDGF)-B and vascular endothelial growth factor-A expression...

Angiogenesis is important in the growth and metastasis of various kinds of solid tumors, including gastric cancers. The ... Cao Y: Opinion: emerging mechanisms of tumour lymphangiogenesis and lymphatic metastasis. Nat Rev Cancer. 2005, 5: 735-743. ... PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis. Cancer Cell. 2004, 6: 333-345. 10.1016/j.ccr. ... Cao Y, Cao R, Hedlund EM: R Regulation of tumor angiogenesis and metastasis by FGF and PDGF signaling pathways. J Mol Med. 2008 ...
more infohttps://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-10-659

The AMEDEO Literature GuideThe AMEDEO Literature Guide

Cervical squamous cell carcinoma-secreted exosomal miR-221-3p promotes lymphangiogenesis and lymphatic metastasis by targeting ... Programmed death ligand 1 promotes lymph node metastasis and glucose metabolism in cervical cancer by activating integrin beta4 ... SPSB3 targets SNAIL for degradation in GSK-3beta phosphorylation-dependent manner and regulates metastasis.. Oncogene. 2018;37: ... TWIST1 induces expression of discoidin domain receptor 2 to promote ovarian cancer metastasis.. Oncogene. 2018 Jan 19. pii: ...
more infohttps://amedeo.com/medicine/gyn/onco.htm

Keystone Symposia | Scientific Conferences on Biomedical and Life Science TopicsKeystone Symposia | Scientific Conferences on Biomedical and Life Science Topics

Lymphangiogenesis: Insights to Lymphedema and Lymphatic Metastasis. William G. Kaelin, Jr., Dana-Farber Cancer Institute, USA ... Tumor Lymphangiogenesis. Hellmut G. Augustin, DKFZ & Heidelberg University, Germany Role of EphB/ephrinB Interactions during ... Angiogenesis and Lymphangiogenesis: Insights from Intravital Microscopy. Gabriele A.I. Bergers, University of California, San ... Short Talk: Recruitment of VEGFR1+ Hematopoietic Progenitors Contributes to the Establishment of Tumor Metastasis. ...
more infohttp://www.keystonesymposia.org/index.cfm?e=web.Meeting.Program&meetingid=664

Axon Guidance Factor SLIT2 Inhibits Neural Invasion and Metastasis in Pancreatic Cancer | Cancer ResearchAxon Guidance Factor SLIT2 Inhibits Neural Invasion and Metastasis in Pancreatic Cancer | Cancer Research

Slit-Robo signaling mediates lymphangiogenesis and promotes tumor lymphatic metastasis. Biochem Biophys Res Commun 2010;396:571 ... and lymphatic metastasis (D; P = 0.035; all Fisher exact test). Number of metastases per mouse increased in DANGROBO1-KD tumor- ... Angiopoietin-2 drives lymphatic metastasis of pancreatic cancer. Faseb J 2011;25:3325-35. ... re-expression of p16 in an orthotopic mouse model of pancreatic cancer inhibits lymphangiogenesis and lymphatic metastasis. Br ...
more infohttps://cancerres.aacrjournals.org/content/74/5/1529?ijkey=26338afae88a3c6165de1df65958cd83c6530f48&keytype2=tf_ipsecsha

Vegfd modulates both angiogenesis and lymphangiogenesis during zebrafish embryonic development | DevelopmentVegfd modulates both angiogenesis and lymphangiogenesis during zebrafish embryonic development | Development

2005). Vascular endothelial growth factor-D induces lymphangiogenesis and lymphatic metastasis in models of ductal pancreatic ... 2002). Metastasis: Lymphangiogenesis and cancer metastasis. Nat. Rev. Cancer 2, 573-583. doi:10.1038/nrc863. ... Arrows indicate the presence of normal medial facial lymphatics (MFL), lateral facial lymphatics (LFL) and otolithic lymphatic ... 2014). Lymphangiogenesis and lymphatic vessel remodelling in cancer. Nat. Rev. Cancer 14, 159-172. doi:10.1038/nrc3677. ...
more infohttps://dev.biologists.org/content/144/3/507?ijkey=c22cc6380812e4506cb98f5f0f7bd1f2c79a9240&keytype2=tf_ipsecsha

Yihai Cao - WikipediaYihai Cao - Wikipedia

"PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis". Cancer Cell. 6 (4): 333-345. doi:10.1016/j. ... They also discovered several lymphangiogenic factors that potentially contribute to cancer metastasis. Cao proposed a new ... a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma". Cell. 79 (2): 315-328. ... of vascular endothelial growth factor receptor-3 signaling inhibits fibroblast growth factor-2-induced lymphangiogenesis in ...
more infohttps://en.wikipedia.org/wiki/Yihai_Cao

Immune response profile of primary tumour, sentinel and non-sentinel axillary lymph nodes related to metastasis in breast...Immune response profile of primary tumour, sentinel and non-sentinel axillary lymph nodes related to metastasis in breast...

Ran S, Volk L, Hall K, Flister MJ (2010) Lymphangiogenesis and lymphatic metastasis in breast cancer. Pathophysiology 17:229- ... Stacker SA, Williams SP, Karnezis T, Shayan R, Fox SB, Achen MG (2014) Lymphangiogenesis and lymphatic vessel remodelling in ... Lymphatic expression of CLEVER-1 in breast cancer and its relationship with lymph node metastasis. Anal Cell Pathol (Amst) 34: ... tumor associated macrophages in gaps of ductal tumor structures negatively correlate with the lymphatic metastasis in human ...
more infohttps://rd.springer.com/article/10.1007%2Fs00418-019-01802-7

An orally administered DNA vaccine targeting vascular endothelial growth factor receptor-3 inhibits lung carcinoma growth |...An orally administered DNA vaccine targeting vascular endothelial growth factor receptor-3 inhibits lung carcinoma growth |...

Soluble vascular endothelial growth factor receptor-3 suppresses lymphangiogenesis and lymphatic metastasis in bladder cancer. ... VEGFR-3 expression in breast cancer tissue is not restricted to lymphatic vessels. Pathol Res Pract. 2005;201(2):93-9. CrossRef ... Suppression of VEGFR-3 signaling inhibits lymph node metastasis in gastric cancer. Cancer Sci. 2004;95(4):328-33. CrossRef ... The VEGF-C/Flt-4 axis promotes invasion and metastasis of cancer cells. Cancer Cell. 2006;9(3):209-23. doi: 10.​1016/​j.​ccr.​ ...
more infohttps://www.springermedizin.de/an-orally-administered-dna-vaccine-targeting-vascular-endothelia/9260374

Collagen I fiber density increases in lymph node positive breast cancers: pilot studyCollagen I fiber density increases in lymph node positive breast cancers: pilot study

S. Hirakawaet al., "VEGF-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis," J. Exp. ... 4 metastasis prediction,5,6 and prognosis of survival.7 Cancer metastasis is a multistep process in which the tumor ... and metastasis,6 and provide the first patient data linking lymph node metastasis with Col1 fiber density. In addition, recent ... versus those without lymph node metastasis (. -<). Col1 fiber density, which was quantified using our in-house SHG image ...
more infohttps://www.spiedigitallibrary.org/journals/journal-of-biomedical-optics/volume-17/issue-11/116017/Collagen-I-fiber-density-increases-in-lymph-node-positive-breast/10.1117/1.JBO.17.11.116017.full

Hypoxia | GreenMedInfo | Disease | Natural Medicine | AlternativeHypoxia | GreenMedInfo | Disease | Natural Medicine | Alternative

Fucoidan suppresses hypoxia-induced lymphangiogenesis and lymphatic metastasis in mouse hepatocarcinoma.Jun 02, 2015. ... Diseases : Cancer Metastasis, Hypoxia, Ovarian Cancer. Pharmacological Actions : Anti-metastatic, Hypoxia inducible factor-1 ... Diseases : Cancer Metastasis, Hypoxia, Liver Cancer. Pharmacological Actions : Anti-Angiogenic, Vascular Endothelial Growth ... Diseases : Cancer Metastasis, Hypoxia, Melanoma. Pharmacological Actions : Anti-Angiogenic, Tumor Suppressor Protein p53 ...
more infohttp://m.greenmedinfo.com/disease/hypoxia

JCM  | Free Full-Text | Epithelial to Mesenchymal Transition and Cell Biology of Molecular Regulation in Endometrial...JCM | Free Full-Text | Epithelial to Mesenchymal Transition and Cell Biology of Molecular Regulation in Endometrial...

... leading to endometrial carcinogenesis and distant metastasis. The PI3K/AKT pathway activates the ransforming growth factor beta ... VEGF induces tumor lymph angiogenesis and it is an important cause of tumor cell metastasis through the lymphatic system [55]. ... Clinical pathological analysis has confirmed that lymphangiogenesis and lymphatic metastasis are early events in the ... HIF-1α and VEGF are also closely related to early lymphatic metastasis of endometrial cancer [52]. ...
more infohttps://www.mdpi.com/2077-0383/8/4/439/htm
  • This review focuses on the role of the immune populations in the primary tumour in the locoregional metastasis of the ALN, and the relationship of the immune response in these regions to distant metastasis. (springer.com)
  • The genetic mutation and germline mitochondrial DNA mutations also impair cell proliferation, anti-apoptosis signaling, and epithelial-mesenchymal transition by several transcription factors, leading to endometrial carcinogenesis and distant metastasis. (mdpi.com)
  • Chondrosarcoma is the second most frequently occurring type of bone malignancy that is characterized by the distant metastasis propensity. (clinsci.org)
  • In recent years, adiponectin is also indicated to facilitate tumorigenesis, angiogenesis and metastasis. (clinsci.org)
  • Also indirectly VEGF-C can be responsible for hereditary lymphedema: The rare Hennekam syndrome can result from the inability of the mutated CCBE1 to assist the ADAMTS3 protease in activating VEGF-C. While a lack of VEGF-C results in lymphedema, too much VEGF-C is implicated in tumor angiogenesis and metastasis. (wikipedia.org)
  • Macrophage-dependent lymphangiogenesis in vitro was triggered upon inflammasome activation and required both S1PR1 signaling and IL-1β production. (rupress.org)
  • We investigated the role of mTOR, which is a downstream kinase of the phosphatidylinositol 3-kinase/Akt pathway, and the MAPK family (MEK1/2, p38, and JNK) in the regulation of VEGF-C and VEGF-A expression in B13LM cells, a lymphatic metastasis-prone pancreatic tumor cell line. (nih.gov)
  • High SR-BI expression was observed in 54 % of all breast cancer cases and was significantly associated with advanced pTNM stage ( P = 0.002), larger tumor size ( P = 0.023), lymph node metastasis ( P = 0.012), and the absence of ER ( P = 0.014). (springer.com)
  • Ammar A, Mohammed RA, Salmi M, Pepper M, Paish EC, Ellis IO, Martin SG (2011) Lymphatic expression of CLEVER-1 in breast cancer and its relationship with lymph node metastasis. (springer.com)
  • Our study is the first to describe the mechanism of adiponectin-promoted lymphangiogenesis by upregulating VEGF-C expression in chondrosarcomas. (clinsci.org)
  • However, the effect of adiponectin on VEGF-C regulation and lymphangiogenesis in chondrosarcoma has largely remained a mystery. (clinsci.org)
  • These results demonstrated that the oral VEGFR-3-based vaccine could induce specific humoral and cellular immune responses and then significantly inhibit lung carcinoma growth via suppressing lymphangiogenesis. (springermedizin.de)
  • In normal lymphatic capillaries, the presence of primarily α4 chain laminins may therefore compromise the formation of endothelial basement membrane, as these truncated laminins lack one of the three arms required for efficient network assembly. (springer.com)
  • In addition to the laminin α4, β1, β2 and γ1 chains, type IV and XVIII collagens and nidogen-1, carcinoma lymphatics showed immunoreactivity for the laminin α5 chain and Lutheran glycoprotein, a receptor for the laminin α5 chain. (springer.com)