A condition in which there is a change of one adult cell type to another similar adult cell type.
A condition with damage to the lining of the lower ESOPHAGUS resulting from chronic acid reflux (ESOPHAGITIS, REFLUX). Through the process of metaplasia, the squamous cells are replaced by a columnar epithelium with cells resembling those of the INTESTINE or the salmon-pink mucosa of the STOMACH. Barrett's columnar epithelium is a marker for severe reflux and precursor to ADENOCARCINOMA of the esophagus.
Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)
Lining of the STOMACH, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. The surface cells produce MUCUS that protects the stomach from attack by digestive acid and enzymes. When the epithelium invaginates into the LAMINA PROPRIA at various region of the stomach (CARDIA; GASTRIC FUNDUS; and PYLORUS), different tubular gastric glands are formed. These glands consist of cells that secrete mucus, enzymes, HYDROCHLORIC ACID, or hormones.
Inflammation of the GASTRIC MUCOSA, a lesion observed in a number of unrelated disorders.
GASTRITIS with atrophy of the GASTRIC MUCOSA, the GASTRIC PARIETAL CELLS, and the mucosal glands leading to ACHLORHYDRIA. Atrophic gastritis usually progresses from chronic gastritis.
A glandular epithelial cell or a unicellular gland. Goblet cells secrete MUCUS. They are scattered in the epithelial linings of many organs, especially the SMALL INTESTINE and the RESPIRATORY TRACT.
Tumors or cancer of the STOMACH.
The muscular membranous segment between the PHARYNX and the STOMACH in the UPPER GASTROINTESTINAL TRACT.
A de novo myeloproliferation arising from an abnormal stem cell. It is characterized by the replacement of bone marrow by fibrous tissue, a process that is mediated by CYTOKINES arising from the abnormal clone.
Infections with organisms of the genus HELICOBACTER, particularly, in humans, HELICOBACTER PYLORI. The clinical manifestations are focused in the stomach, usually the gastric mucosa and antrum, and the upper duodenum. This infection plays a major role in the pathogenesis of type B gastritis and peptic ulcer disease.
An organ of digestion situated in the left upper quadrant of the abdomen between the termination of the ESOPHAGUS and the beginning of the DUODENUM.
A spiral bacterium active as a human gastric pathogen. It is a gram-negative, urease-positive, curved or slightly spiral organism initially isolated in 1982 from patients with lesions of gastritis or peptic ulcers in Western Australia. Helicobacter pylori was originally classified in the genus CAMPYLOBACTER, but RNA sequencing, cellular fatty acid profiles, growth patterns, and other taxonomic characteristics indicate that the micro-organism should be included in the genus HELICOBACTER. It has been officially transferred to Helicobacter gen. nov. (see Int J Syst Bacteriol 1989 Oct;39(4):297-405).
That part of the STOMACH close to the opening from ESOPHAGUS into the stomach (cardiac orifice), the ESOPHAGOGASTRIC JUNCTION. The cardia is so named because of its closeness to the HEART. Cardia is characterized by the lack of acid-forming cells (GASTRIC PARIETAL CELLS).
High molecular weight mucoproteins that protect the surface of EPITHELIAL CELLS by providing a barrier to particulate matter and microorganisms. Membrane-anchored mucins may have additional roles concerned with protein interactions at the cell surface.
Inflammation of the DUODENUM section of the small intestine (INTESTINE, SMALL). Erosive duodenitis may cause bleeding in the UPPER GI TRACT and PEPTIC ULCER.
A gel-forming mucin that is primarily found on the surface of gastric epithelium and in the RESPIRATORY TRACT. Mucin 5AC was originally identified as two distinct proteins, however a single gene encodes the protein which gives rise to the mucin 5A and mucin 5C variants.
The section of the alimentary canal from the STOMACH to the ANAL CANAL. It includes the LARGE INTESTINE and SMALL INTESTINE.
Endoscopic examination, therapy or surgery of the esophagus.
The development of bony substance in normally soft structures.
An EPITHELIUM with MUCUS-secreting cells, such as GOBLET CELLS. It forms the lining of many body cavities, such as the DIGESTIVE TRACT, the RESPIRATORY TRACT, and the reproductive tract. Mucosa, rich in blood and lymph vessels, comprises an inner epithelium, a middle layer (lamina propria) of loose CONNECTIVE TISSUE, and an outer layer (muscularis mucosae) of SMOOTH MUSCLE CELLS that separates the mucosa from submucosa.
Endoscopic examination, therapy or surgery of the interior of the stomach.
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
A gel-forming mucin found predominantly in SMALL INTESTINE and variety of mucous membrane-containing organs. It provides a protective, lubricating barrier against particles and infectious agents.
A malignant epithelial tumor with a glandular organization.
A gel-forming mucin that is predominantly associated with the gastric epithelium.
The region between the sharp indentation at the lower third of the STOMACH (incisura angularis) and the junction of the PYLORUS with the DUODENUM. Pyloric antral glands contain mucus-secreting cells and gastrin-secreting endocrine cells (G CELLS).
Epithelial cells that line the basal half of the GASTRIC GLANDS. Chief cells synthesize and export an inactive enzyme PEPSINOGEN which is converted into the highly proteolytic enzyme PEPSIN in the acid environment of the STOMACH.
Tumors or cancer of the ESOPHAGUS.
The area covering the terminal portion of ESOPHAGUS and the beginning of STOMACH at the cardiac orifice.
One or more layers of EPITHELIAL CELLS, supported by the basal lamina, which covers the inner or outer surfaces of the body.
The viscous secretion of mucous membranes. It contains mucin, white blood cells, water, inorganic salts, and exfoliated cells.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Retrograde flow of gastric juice (GASTRIC ACID) and/or duodenal contents (BILE ACIDS; PANCREATIC JUICE) into the distal ESOPHAGUS, commonly due to incompetence of the LOWER ESOPHAGEAL SPHINCTER.
Mucins that are found on the surface of the gastric epithelium. They play a role in protecting the epithelial layer from mechanical and chemical damage.
The shortest and widest portion of the SMALL INTESTINE adjacent to the PYLORUS of the STOMACH. It is named for having the length equal to about the width of 12 fingers.
Pathological processes involving the STOMACH.
Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).
A type II keratin found associated with KERATIN-19 in ductal epithelia and gastrointestinal epithelia.
An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.
The mucous membrane lining the RESPIRATORY TRACT, including the NASAL CAVITY; the LARYNX; the TRACHEA; and the BRONCHI tree. The respiratory mucosa consists of various types of epithelial cells ranging from ciliated columnar to simple squamous, mucous GOBLET CELLS, and glands containing both mucous and serous cells.
A type I keratin expressed predominately in gastrointestinal epithelia, MERKEL CELLS, and the TASTE BUDS of the oral mucosa.
Large, branched, specialized sweat glands that empty into the upper portion of a HAIR FOLLICLE instead of directly onto the SKIN.
A species of HELICOBACTER that colonizes in the STOMACH of laboratory MICE; CATS; and DOGS. It is associated with lymphoid follicular hyperplasia and mild GASTRITIS in CATS.
A PEPTIC ULCER located in the DUODENUM.
Endoscopic examination, therapy or surgery of the gastrointestinal tract.
Retrograde bile flow. Reflux of bile can be from the duodenum to the stomach (DUODENOGASTRIC REFLUX); to the esophagus (GASTROESOPHAGEAL REFLUX); or to the PANCREAS.
A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.
The larger air passages of the lungs arising from the terminal bifurcation of the TRACHEA. They include the largest two primary bronchi which branch out into secondary bronchi, and tertiary bronchi which extend into BRONCHIOLES and PULMONARY ALVEOLI.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.

Hybrid capture II, a new sensitive test for human papillomavirus detection. Comparison with hybrid capture I and PCR results in cervical lesions. (1/1094)

AIM: To test a new assay for the detection of human papillomavirus (HPV) DNA, hybrid capture II (HC II), compared with the previous commercialized hybrid capture I (HC I) and polymerase chain reaction (PCR) results on cervical scrapes from fresh cone excision biopsy samples. METHODS: The three methods were used on cervical scrapes from 42 fresh cone excision biopsy samples. There were nine metaplastic and inflammatory lesions, five low grade lesions, and 28 high grade lesions. PCR was performed using the general primers GP5+/GP6+. The viral load of high risk HPV DNA was estimated by the ratio of relative light units to positive control values in the samples. RESULTS: The sensitivity of HC I for the detection of high grade lesions was 71.4%, while it was 92.8% for HC II and 96.4% for the PCR. Considering only the absence of detectable cervical in situ neoplasia, the specificity was 88.9% for HC I, 66.7% for HC II, and 66.7% for PCR. With HC II, for a ratio of cervical sample to normal control of > 200, the sensitivity for the detection of high grade lesion was only 34.6% with a specificity of 66.7%. CONCLUSIONS: HPV detection with the HC II assay is more sensitive than the previous HC I and represents a more convenient and easier test than PCR for routine use. Nevertheless the viral load estimated with this test cannot be a reliable predictive indicator of high grade lesions.  (+info)

Precancerous lesions in two counties of China with contrasting gastric cancer risk. (2/1094)

BACKGROUND: Gastric cancer (GC) is one of the most common cancers worldwide and shows remarkable geographical variation even within countries such as China. Linqu County in Shandong Province of northeast China has a GC rate that is 15 times higher than that of Cangshan County in Shandong, even though these counties are within 200 miles of each other. METHOD: In order to evaluate the frequency of precancerous gastric lesions in Linqu and Cangshan Counties we examined 3400 adults in Linqu County and 224 adults in Cangshan County. An endoscopic examination with four biopsies was performed in each individual of the two populations. RESULTS: The prevalence of intestinal metaplasia (IM) and dysplasia (DYS) was 30% and 15.1%, respectively, in Linqu compared to 7.9% and 5.6% in Cangshan (P < 0.01). Within these histological categories, advanced grades were found more often in Linqu than in Cangshan. The prevalences of IM and DYS were more common at each biopsy site in Linqu, where the lesions also tended to affect multiple sites. CONCLUSIONS: The findings of this study support the concept that IM and DYS are closely correlated with risks of GC and represent late stages in the multistep process of gastric carcinogenesis.  (+info)

KRAS mutations predict progression of preneoplastic gastric lesions. (3/1094)

Eight hundred sixty-three subjects with atrophic gastritis were recruited to participate in an ongoing chemoprevention trial in Narino, Colombia. The participants were randomly assigned to intervention therapies, which included treatment to eradicate Helicobacter pylori infection followed by daily dietary supplementation with antioxidant micronutrients in a 2 x 2 x 2 factorial design. A series of biopsies of gastric mucosa were obtained according to a specified protocol from designated locations in the stomach for each participant at baseline (before intervention therapy) and at year three. A systematic sample of 160 participants was selected from each of the eight treatment combinations. DNA was isolated from each of these biopsies (n = 320), and the first exon of KRAS was amplified using PCR. Mutations in the KRAS gene were detected using denaturing gradient gel electrophoresis and confirmed by sequence analysis. Of all baseline biopsies, 14.4% (23 of 160) contained KRAS mutations. Among those participants with atrophic gastritis without metaplasia, 19.4% (6 of 25) contained KRAS mutations, indicating that mutation of this important gene is likely an early event in the etiology of gastric carcinoma. An important association was found between the presence of KRAS mutations in baseline biopsies and the progression of preneoplastic lesions. Only 14.6% (20 of 137) of participants without baseline KRAS mutations progressed from atrophic gastritis to intestinal metaplasia or from small intestinal metaplasia to colonic metaplasia; however, 39.1% (9 of 23) with baseline KRAS mutations progressed to a more advanced lesion after 3 years [univariate odds ratio (OR), 3.76 (P = 0.05); multivariate OR adjusted for treatment, 3.74 (P = 0.04)]. In addition, the specificity of the KRAS mutation predicted progression. For those participants with G-->T transversions at position 1 of codon 12 (GGT-->TGT), 19.4% (5 of 17) progressed (univariate OR, 2.4); however, 60.0% (3 of 5) of participants with G-->A transitions at position 1 of codon 12 (GGT-->AGT) progressed (univariate OR, 8.7; P = 0.004 using chi2 test).  (+info)

Apoptotic activity is increased in parallel with the metaplasia-dysplasia-carcinoma sequence of the bronchial epithelium. (4/1094)

A high level of apoptotic activity and an independence of apoptosis from the expression of p53 and bcl-2 have been observed in non-small-cell lung carcinoma. We examined 44 samples of normal, metaplastic and premalignant (i.e. mild, moderate and severe dysplasias and carcinoma in situ) bronchial epithelia to evaluate whether differences in the apoptotic activity could already be seen in the stages preceding squamous cell carcinoma of the lung (SQCLC). Apoptotic cells and bodies were visualized by 3' end labelling. The expression of p53 and members of the bcl-2 gene family, such as bcl-2, bax and mcl-1, were determined immunohistochemically with specific antibodies. The relative number of apoptotic cells and bodies [apoptotic index (AI%)] was already increased threefold as the normal bronchial epithelium changed to squamous metaplasia, and the AIs of the dysplastic lesions were about four times higher than those of the normal epithelium. Apoptosis was significantly associated with cell proliferation, as determined by proliferating cell nuclear antigen (PCNA) immunohistochemistry. However, the extent of apoptosis did not correlate with the expression of p53, bcl-2, bax and mcl-1. We conclude that, in the metaplasia-dysplasia-carcinoma sequence in the lung, the elevation of the AI% is an early event associated with cell proliferation activity, but is independent of the expression of p53, bcl-2, mcl-1 and bax.  (+info)

Intestinal metaplasia of human stomach displays distinct patterns of mucin (MUC1, MUC2, MUC5AC, and MUC6) expression. (5/1094)

Intestinal metaplasia is a well-established premalignant condition of the stomach that is characterized by mucin carbohydrate modifications defined by histochemical methods. The purpose of the present study was to see whether the expression of mucin core proteins was modified in the different types of intestinal metaplasia and to evaluate the putative usefulness of mucins as "molecular markers" in this setting. We used a panel of monoclonal antibodies with well-defined specificities to MUC1, MUC2, MUC5AC, and MUC6 to characterize the expression pattern of mucins. In contrast to normal gastric mucosa, the complete form or type I intestinal metaplasia (n = 20) displayed little or no expression of MUC1, MUC5AC, or MUC6 in the metaplastic cells and strong expression of the intestinal mucin MUC2 in the goblet cells of all cases. The incomplete forms of intestinal metaplasia, type II (n = 25) and type III (n = 16), expressed MUC1 and MUC5AC in every case, both in goblet and in columnar cells. MUC6 was also expressed in 16 cases of type II intestinal metaplasia and in 11 cases of type III intestinal metaplasia. The intestinal mucin MUC2 was expressed in every case of incomplete intestinal metaplasia, mostly in goblet cells. The mucin expression profile in the different types of intestinal metaplasia allows the identification of two patterns: one defined by decreased levels of expression of "gastric" mucins (MUC1, MUC5AC, and MUC6) and expression of MUC2 intestinal mucin, which corresponds to type I intestinal metaplasia, and the other defined by coexpression of "gastric mucins" (MUC1, MUC5AC, and MUC6) together with the MUC2 mucin, encompassing types II and III intestinal metaplasia. Our results challenge the classical sequential pathway of intestinal metaplasia (from type I to type III via a type II intermediate step).  (+info)

Helicobacter pylori-induced chronic active gastritis, intestinal metaplasia, and gastric ulcer in Mongolian gerbils. (6/1094)

The establishment of persisting Helicobacter pylori infection in laboratory animals has been difficult, but in 1996 Hirayama reported the development of a successful Mongolian gerbil model. The present study was undertaken with two aims: to better characterize the normal histological structure and histochemical properties of the gastric mucosa of the Mongolian gerbil; and to evaluate the progression of the histopathological features of H. pylori-induced gastritis in this animal model for one year after the experimental infection. Seventy-five Mongolian gerbils were used. Mongolian gerbils were sacrificed at 2, 4, 8, 12, 26, 38, and 52 weeks after H. pylori inoculation. Sections prepared from stomachs immediately fixed in Carnoy's solution were stained with hematoxylin and eosin and Alcian blue at pH 2.5/periodic acid-Schiff, a dual staining consisting of the galactose oxidase-cold thionin Schiff reaction and paradoxical Concanavalin A staining, and with immunostaining for H. pylori and BrdU. H. pylori infection induced in the Mongolian gerbil a chronic active gastritis, in which a marked mucosal infiltration of neutrophils on a background of chronic inflammation became detectable 4 weeks after inoculation and continued up to 52 weeks. Intestinal metaplasia and gastric ulcers appeared after 26 weeks in some of the animals, whereas others developed multiple hyperplastic polyps. The Mongolian gerbil represents a novel and useful model for the study of H. pylori-induced chronic active gastritis and may lend itself to the investigation of the epithelial alterations that lead to intestinal metaplasia and gastric neoplasia.  (+info)

Pathologic changes induced in respiratory tract mucosa by polycyclic hydrocarbons of differing carcinogenic activity. (7/1094)

Seven aromatic polycyclic hydrocarbons (PCHs) were investigated for their toxic effects on respiratory mucosa: benzo(e)pyrene (BeP), pyrene, anthracene, benz(a)anthracene(BaA), dibenz(a,c)anthracene(DBacA), benzo (a)pyrene (BaP), and dimethylbenz(a)anthracene (DMBA). The compounds were chosen because they comprise a spectrum of PCHs ranging from noncarcinogens, to initiators, to weak and strong carcinogens. All of them except DMBA are environmentally relevant chemicals. The chemicals were tested over an 8-week period. Heterotopic tracheal transplants were continously exposed and the histopathologic effects induced by the various PCHs were periodically assessed semiquantitatively. All PCHs exhibited varying degrees of toxicity for respiratory epithelium and submucosa. BeP clearly showed the least toxicity followed by pyrene and anthracene. BaA and DBacA caused marked epithelial and submucosal changes. In addition to epithelial hyperplasia, undifferentiated epithelium and squamous metaplasia developed. Marked mononuclear infiltration occurred in the subepithelial connective tissue. With BaP the epithelial and submucosal changes were similar but were much stronger. DMBA was the most toxic substance, causing epithelial necrosis followed by generalized keratinizing squamous metaplasia; the subepithelial changes consisted of an early acellular exudate and, later (at 8 weeks), marked condensation and hyalinization of the lamina propria. The toxic response pattern of the tracheal mucosa to carcinogenic agents was characterized by the chronicity of epithelial and connective tissue damage, as opposed to the short-lived hyperplastic and inflammatory response elicited by the noncarcinogens and weak initiators.  (+info)

Helicobacter pylori infection enhances glandular stomach carcinogenesis in Mongolian gerbils treated with chemical carcinogens. (8/1094)

Helicobacter pylori (Hp) is thought to be a stomach carcinogen from epidemiological findings. To determine the effects of infection with the bacteria on experimental carcinogenesis, a study of the glandular stomach of Mongolian gerbils (MGs) was performed. Male MGs were treated with N-methyl-N'-nitro-N-nitrosoguanidine followed by inoculation with Hp or infected with Hp followed by N-methyl-N'-nitro-N-nitrosoguanidine administration. Animals were killed at week 50, and their excised stomachs underwent microbiological and histopathological examinations. In addition, a serological investigation was performed. The incidences of adenocarcinomas were significantly higher in animals treated with 60 or 300 p.p.m. N-methyl-N'-nitro-N-nitrosoguanidine for 10 weeks followed by Hp inoculation or Hp followed by 20 p.p.m. N-methyl-N'-nitro-N-nitrosoguanidine for 30 weeks than in the respective controls. Moreover, tumour-bearing animals had higher titres of anti-Hp antibodies than tumour-free animals. Of interest was the finding that a dose of 100 p.p.m. N-methyl-N'-nitro-N-nitrosoguanidine given to infected gerbils eradicated the Hp in about half the animals, with a concomitant reduction in the promoting effect. No tumours were found in animals infected with Hp without N-methyl-N'-nitro-N-nitrosoguanidine or non-treated gerbils. Hp infection enhances glandular stomach carcinogenesis in MGs treated with N-methyl-N'-nitro-N-nitrosoguanidine. Animals with high titres of anti-Hp antibodies are at greatest risk of developing neoplasms.  (+info)

TY - JOUR. T1 - Macrophages promote progression of spasmolytic polypeptide-expressing metaplasia after acute loss of parietal cells. AU - Petersen, Christine P.. AU - Weis, Victoria G.. AU - Nam, Ki Taek. AU - Sousa, Josane F.. AU - Fingleton, Barbara. AU - Goldenring, James R.. N1 - Copyright: Copyright 2018 Elsevier B.V., All rights reserved.. PY - 2014/6. Y1 - 2014/6. N2 - Background & Aims Loss of parietal cells causes the development of spasmolytic polypeptide-expressing metaplasia (SPEM) through transdifferentiation of chief cells. In the presence of inflammation, SPEM can advance into a more proliferative metaplasia with increased expression of intestine-specific transcripts. We used L635 to induce acute SPEM with inflammation in mice and investigated the roles of inflammatory cells in the development of SPEM. Methods To study the adaptive immune system, Rag1 knockout, interferon-γ-deficient, and wild-type (control) mice received L635 for 3 days. To study the innate immune system, ...
Magnified intelligence chromoendoscopy (FICE) plus probe-based confocal laser endomicroscopy (pCLE) for Gastric Intestinal Metaplasia (GIM) diagnosis: a feasibility trial. Research Question:. Is confocal endomicroscope feasible to diagnose gastric intestinal metaplasia?. Objective:. To evaluate the feasibility of confocal endomicroscope in diagnose gastric intestinal metaplasia.. Hypothesis:. Confocal endomicreosocpe can provide the accurate diagnosis of gastric intestinal metaplasia.. Research design:. Diagnostic study. Sample size:. The investigators follow the population in recent study from Imraporn et al.: Validity of magnify NBI for gastric intestinal metaplasia targeted biopsy (N= 50). Data analysis:. Confocal Barretts esophagus classification was used to evaluate agreement of confocal endomicroscopic finding in gastric intestinal metaplasia. The accuracy of new criteria for GIM by confocal endomicroscope was evaluated in relation to pathological report, a gold standard for diagnosis, ...
참고문헌 1: Goldenring & Nam. Prog Mol Biol Transl Sci (2010) Review; Oxyntic atrophy, metaplasia, and gastric cancer - Gastric carcinogenesis involves the loss of parietal cells (oxyntic atrophy) and subsequent replacement of the normal gastric lineages with metaplastic cells. In humans, two metaplastic lineages develop as sequelae of chronic Helicobacter pylori infection: intestinal metaplasia and spasmolytic polypeptide-expressing metaplasia (SPEM). Mouse models of both chronic Helicobacter infection and acute pharmacological oxyntic atrophy have led to the discovery that SPEM arises from transdifferentiation of mature chief cells. The presence of inflammation promotes the expansion of SPEM in mice. Furthermore, studies in Mongolian gerbils as well as increasing evidence from human studies indicate that SPEM likely represents a precursor for the development of intestinal metaplasia. These findings suggest that loss of parietal cells, augmented by chronic inflammation, leads to a cascade ...
Synonyms for cartilaginous metaplasia in Free Thesaurus. Antonyms for cartilaginous metaplasia. 2 synonyms for cartilaginous: gristly, rubbery. What are synonyms for cartilaginous metaplasia?
Intestinal metaplasia of the bladder is an uncommon glandular proliferation. We examined a large series of intestinal metaplasia for the clinicopathological features and discuss the significance of this lesion. All cases of intestinal metaplasia diagnosed in our institution between 1990 and 2014 were retrospectively reviewed. Patients with a history of urothelial carcinoma or concurrent adenocarcinoma were excluded. Patient characteristics, pathological features, and follow-up outcomes were obtained. We identified 89 patients with intestinal metaplasia during this period. Sixty seven were men and 22 were women. Mean age at diagnosis was 57 years (range 23-81). Common presenting complaints included haematuria (73 cases), mucosuria (13 cases), and irritative voiding symptoms (seven cases). The majority of intestinal metaplasias located on or near the trigone (67 cases). Eighty-two patients underwent transurethral resection of their lesions. Partial cystectomy was performed in the remaining seven patients.
Gastric cancer exhibits familial clustering, and gastric cancer familial relatives (GCF) tend to present with corpus-predominant gastritis and precancerous lesions as SPEM or IM after H. pylori infection. The study determined whether the children of gastric cancer patients (GCA) had genomic single nucleotide polymorphisms (SNPs) predisposed to the gastric precancerous lesions as spasmolytic polypeptide-expressing metaplasia (SPEM) or intestinal metaplasia (IM). There were 389 family relatives of 193 non-cardiac GCA and 173 duodenal ulcer patients (DU), received blood sampling for DNA collection. The differences of the risk alleles of SNPs in the ITGA5, ITGB1, IL-10, COX-2, RUNX3, and TFF2 genes were compared between 195 children of GCA and 143 DU. The children of GCA had higher allele frequencies of ITGA5-1160 T-carrier (P = 0.006, OR[95% CI] = 2.2[1.2-4]), ITGB1-1949 A-carrier (P = 0.047; OR[95% CI] = 2.8[1.4-5.3]), ITGB1 + 31804 C-carrier (P = 0.013; OR[95% CI] = 4.7[1.7-13.0]), IL-10-592 AA (P = 0
In the stomach, chronic inflammation causes metaplasia and creates a favorable environment for the evolution of gastric cancer. Glucocorticoids are steroid hormones that repress proinflammatory stimuli, but their role in the stomach is unknown. In this study, we show that endogenous glucocorticoids are required to maintain gastric homeostasis. Removal of circulating glucocorticoids in mice by adrenalectomy resulted in the rapid onset of spontaneous gastric inflammation, oxyntic atrophy, and spasmolytic polypeptide-expressing metaplasia (SPEM), a putative precursor of gastric cancer. SPEM and oxyntic atrophy occurred independently of lymphocytes. However, depletion of monocytes and macrophages by clodronate treatment or inhibition of gastric monocyte infiltration using the Cx3cr1 knockout mouse model prevented SPEM development. Our results highlight the requirement for endogenous glucocorticoid signaling within the stomach to prevent spontaneous gastric inflammation and metaplasia, and suggest ...
Gastric intestinal metaplasia (GIM) is a significant risk factor for gastric cancer. Risk of gastric cancer/dysplasia between complete intestinal metaplasia (CIM) and incomplete intestinal metaplasia (IIM) was controversial. Our study aimed to pool relative risk (RR) of cancer/dysplasia of IIM compared with CIM in GIM patients. PubMed, EMBASE, Cochrane Library and Web of Science were searched for studies concerning cancer/dysplasia in GIM patients. Random-effects or fixed-effects model was utilized for pooling RR. Sensitivity and publication bias analyses were conducted. Stability of results would be evaluated in case of publication bias. 12 studies were included. Compared with CIM, pooled RR of cancer/dysplasia in IIM patients was 4.48 (95% CI 2.50-8.03), and the RR was 4.96 (95% CI 2.72-9.04) for cancer, and 4.82 (95% CI 1.45-16.0) for dysplasia. The pooled RR for cancer/dysplasia in type III IM was 6.27 (95% CI 1.89-20.77) compared with type II + I IM, while it was 5.55 (95% CI 2.07-14.92) compared
Metaplasia is a change in which one terminally differentiated cell type is replaced by another cell type of the same germ line. Usually, a specialized type of epithelium is replaced by less specialized type of epithelium. Metaplasia is often, but not always, an adaptive change that occurs in response to repeated epithelial damage and is therefore often accompanied by other lesions such as inflammation or necrosis. Squamous metaplasia may be reversible if the cause is removed. Squamous metaplasia is a common form of metaplasia, presumably because squamous epithelium is more resistant to damage than other forms of epithelia. Squamous metaplasia is usually the result of chronic irritation, but it can have other causes (e.g., hypovitamnosis A). In the salivary ducts, metaplasia of the normally cuboidal ductal epithelium to stratified squamous epithelium has been seen in response to chemicals, ionizing radiation, viral infections, vitamin A deficiency, and blockage of ducts by salivary calculi. ...
TY - JOUR. T1 - Whole-exome sequencing of metaplastic breast carcinoma indicates monoclonality with associated ductal carcinoma component. AU - Avigdor, Bracha Erlanger. AU - Beierl, Katie. AU - Gocke, Christopher. AU - Zabransky, Daniel J.. AU - Cravero, Karen. AU - Kyker-Snowman, Kelly. AU - Button, Berry. AU - Chu, David. AU - Croessmann, Sarah. AU - Cochran, Rory L.. AU - Connolly, Roisin. AU - Park, Ben H.. AU - Wheelan, Sarah. AU - Cimino-Mathews, Ashley M. PY - 2017/8/15. Y1 - 2017/8/15. N2 - Purpose: Although most human cancers display a single histology, there are unusual cases where two or more distinct tissue types present within a primary tumor. One such example is metaplastic breast carcinoma, a rare but aggressive cancer with a heterogeneous histology, including squamous, chondroid, and spindle cells. Metaplastic carcinomas often contain an admixed conventional ductal invasive or in situ mammary carcinoma component, and are typically triple-negative for estrogen receptor, ...
Metaplastic breast carcinomas frequently overexpressed EGFR, which was associated with EGFR gene amplification in one-third of cases. Our findings suggest that some patients with metaplastic breast carcinomas might benefit from novel therapies targeting EGFR. Because most metaplastic breast carcinom …
Localisation digestive intestinal metaplasia esophageal intestinal metaplasia / Barrett esophagus gastric intestinal metaplasia intestinal (...)
TY - JOUR. T1 - Uterine metaplasia and plasma levels of vitamin A. AU - Reiter, Russel J.. PY - 1965/5. Y1 - 1965/5. N2 - The relationship between vitamin A deficiency and estrogen as etiological agents of uterine stratified squamous metaplasia (keratinizing metaplasia) was studied using the rat. This is the initial attempt to correlate plasma levels of vitamin A with the uterine lesions. From the results the following conclusions can be drawn. Uterine metaplastic lesions which develop in estrogen‐treated rats are not a result of generalized hypovitaminosis A, since plasma levels of vitamin A are not altered in animals treated with estrogen. Estrogen per se can cause uterine keratinizing metaplasia. The histopathologic lesions occur more frequently in vitamin Adeficient estrogenized rats having decreased plasma vitamin A levels as compared to rats with normal vitamin A intake. The two insults are complementary in producing epithelial metaplasia of the endometrium of the rat.. AB - The ...
What is chronic gastritis with intestinal metaplasia (intestinal metaplasia)?,After the completion of gastroscopy and biopsy of patients to take the report, and sometimes will see such a few words: intestinal +, of cou
The presence and the extent of gastric intestinal metaplasia(IM) is a good indicator of high risk group of gastric cancer. Many methods was developed to survey it, including multiple gastric biopsy or methylene blue chromoendoscopy. But they are not practical in the routine screening exam, limited by cost and accessibility. Spraying of acetic acid is commonly used in screening cervical cancer, to induce whitish discoloration of metaplastic mucosa. The investigators have confirmed such whitish discoloration is induced in gastric IM, with accuracy , 80% in a pilot study of the investigators. This prospective study will tell the accuracy, sensitivity and specificity of acetic acid chromoendoscopy for judging gastric IM ...
OPCML hypermethylation is considered a promising cancer biomarker. We examined methylation levels in the first exon of OPCML in two patient cohorts within the esophageal adenocarcinoma and gastric adenocarcinoma cascades and in a range of cell-lines using a custom PyroMark CpG assay. Methylation levels were significantly higher in esophageal tissue with histologically confirmed glandular mucosa as compared to tissue from normal esophagi or gastro-esophageal reflux disease. Higher levels of OPCML methylation were absent in the adjacent normal esophageal tissue of patients with glandular mucosa. Higher levels of methylation were confirmed in cell-lines derived from patients with adenocarcinoma, but also detected in two cell-lines with signs of dysplasia. We validated our assay by showing no differences in methylation levels in DNA extracted from blood of patients within the gastric adenocarcinoma cascade. OPCML hypermethylation is present in a subset of patients with metaplastic changes in their esophagus
There is minimal information regarding the prevalence of intratumoral adipose in renal cell carcinoma (RCC), and no study has assessed the impact of intratumoral adipose on the preoperative imaging diagnosis. The aim of this study was to investigate the prevalence and histopathologic characteristics of entrapped adipose with or without osseous metaplasia in RCC nephrectomy specimens and to determine if this finding impacted the preoperative imaging interpretation. 704 RCC specimens were prospectively evaluated for entrapped adipose and osseous metaplasia (423 partial nephrectomies, 281 total nephrectomies; 327 pT1a, 377 ≥ pT1b; 510 clear cell, 119 papillary, 30 chromophobe, 22 clear cell papillary, 23 other). Imaging reports were obtained, and the presence of intratumoral fat or calcification and the radiologic diagnostic impression were recorded. 3% (n = 21) contained microscopically identified intratumoral adipose, with a similar frequency in the main histologic subtypes (p = 0.76). Mean metaplastic
TY - JOUR. T1 - Dietary habits and the risk of stomach cancer. T2 - A comparison study of patients with and without intestinal metaplasia. AU - Fay, Martha. AU - Fennerty, M (Brian). AU - Emerson, Julia. AU - Larez, Mary. PY - 1994. Y1 - 1994. N2 - Patients with chronic atrophic gastritis intestinal metaplasia (IM) are suspected of being at increased risk for the intestinal type of gastric cancer. Diet is one of several etiologic components that may contribute to the development of the IM lesion. One hundred patients (50 with IM and 50 without IM) were evaluated to determine their dietary intake of nitrosating agents and vitamin C and their smoking habits. Patients with IM reported a higher consumption of two foods rich in nitrosating agents, bacon (.28 vs. .10, p = .02) and sausages (.16 vs. .02, p = .01), compared to patients without IM. Smoking and vitamin C intake were similar in both the IM-positive and the IM-negative groups.. AB - Patients with chronic atrophic gastritis intestinal ...
Metaplastic carcinoma of the breast: multimodality imaging and histopathologic assessment. Nov 2011 Choi BB, Shu KS. Source Department of Radiology. Correspondence to: Bo Bae Choi. Email: [email protected] Abstract BACKGROUND Metaplastic carcinomas are ductal carcinomas that display metaplastic transformation of the glandular epithelium to non-glandular mesenchymal tissue. Metaplastic carcinoma has a poorer prognosis than most other breast cancers, so the differential diagnosis is important. Although many clinical and pathologic findings have been reported, to our knowledge, few imaging findings related to metaplastic carcinoma have been reported.PurposeTo investigate whole-breast imaging findings, including mammography, sonography, MRI, and pathologic findings, including immunohistochemical studies of metaplastic carcinomas of the breast. MATERIAL AND METHODS: We analyzed 33 cases of metaplastic carcinoma between January 2001 and January 2011. Mammography, ultrasonography, and MRI were recorded ...
TY - JOUR. T1 - Adenocarcinoma risk in gastric atrophy and intestinal metaplasia: a systematic review. AU - Spence, Andrew D.. AU - Cardwell, Chris R.. AU - McMenamin, Úna C.. AU - Hicks, Blanaid M.. AU - Johnston, Brian T.. AU - Murray, Liam J.. AU - Coleman, Helen G.. PY - 2017/12/11. Y1 - 2017/12/11. N2 - Background: Gastric cancer (GC) has a poor prognosis with wide variation in survival rates across the world. Several studies have shown premalignant lesions gastric atrophy (GA) and intestinal metaplasia (IM) influence gastric cancer risk. This systematic review examines all available evidence of the risk of GC in patients with GA or IM and explores the geographical variation between countries. Methods: EMBASE, MEDLINE, Web of Science and the Cochrane Library were searched for relevant articles published to June 2016 investigating the risk of GC in individuals with GA or IM. Analysis was performed to determine variation based on geographical location. Study quality was assessed using the ...
Results We identified several genes as potential targets of miRNAs altered during metaplasia progression. We showed evidence that HNF4γ (upregulated in intestinal metaplasia) is targeted by miR-30 and that miR-194 targets a known co-regulator of HNF4 activity, NR2F2 (downregulated in intestinal metaplasia). Intestinal metaplasia markers such as VIL1, TFF2 and TFF3 were downregulated after overexpression of miR-30a in a HNF4γ-dependent manner. In addition, overexpression of HNF4γ was sufficient to induce the expression of VIL1 and this effect was potentiated by downregulation of NR2F2. ...
TY - JOUR. T1 - Cancer-associated acinar-to-ductal metaplasia within the invasive front of pancreatic cancer contributes to local invasion. AU - Kibe, Shin. AU - Ohuchida, Kenoki. AU - Ando, Yohei. AU - Takesue, Shin. AU - Nakayama, Hiromichi. AU - Abe, Toshiya. AU - Endo, Sho. AU - Koikawa, Kazuhiro. AU - Okumura, Takashi. AU - Iwamoto, Chika. AU - Shindo, Koji. AU - Moriyama, Taiki. AU - Nakata, Kohei. AU - Miyasaka, Yoshihiro. AU - Shimamoto, Masaya. AU - Ohtsuka, Takao. AU - Mizumoto, Kazuhiro. AU - Oda, Yoshinao. AU - Nakamura, Masafumi. N1 - Funding Information: This work was supported in part by JSPS KAKENHI (Grant Numbers JP16H05418, JP16K10601, JP17H04284, JP17K19602, JP17K19605, JP18K07943).The authors thank E. Manabe, S. Sadatomi, N. Torada (Department of Surgery and Oncology, Kyushu University Hospital), and members of the Research Support Center and Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University for their expert technical assistance. The ...
When cells are faced with physiological or pathological stresses, they respond by adapting in any of several ways, one of which is metaplasia. It is a benign (i.e. non-cancerous) change that occurs as a response to change of milieu (physiological metaplasia) or chronic physical or chemical irritation. One example of pathological irritation is cigarette smoke, which causes the mucus-secreting ciliated pseudostratified columnar respiratory epithelial cells that line the airways to be replaced by stratified squamous epithelium, or a stone in the bile duct that causes the replacement of the secretory columnar epithelium with stratified squamous epithelium (squamous metaplasia). Metaplasia is an adaptation that replaces one type of epithelium with another that is more likely to be able to withstand the stresses it is faced with. It is also accompanied by a loss of endothelial function, and in some instances considered undesirable; this undesirability is underscored by the propensity for metaplastic ...
The sodium/iodide symporter (NIS) is a plasma membrane glycoprotein that mediates iodide (I-) transport in the thyroid, lactating breast, salivary glands, and stomach. Whereas NIS expression and regulation have been extensively investigated in healthy and neoplastic thyroid and breast tissues, little is known about NIS expression and function along the healthy and diseased gastrointestinal tract. Thus, we investigated NIS expression by immunohistochemical analysis in 155 gastrointestinal tissue samples and by immunoblot analysis in 17 gastric tumors from 83 patients. Regarding the healthy Gl tract, we observed NIS expression exclusively in the basolateral region of the gastric mucin-producing epithelial cells. In gastritis, positive NIS staining was observed in these cells both in the presence and absence of Helicobacter pylori. Significantly, NIS expression was absent in gastric cancer, independently of its histological type. Only focal faint NIS expression was detected in the direct vicinity of
Epithelial hyperplasia and metaplasia are common features of inflammatory and neoplastic disease, but the basis for the altered epithelial phenotype is often uncertain. Here we show that long-term ciliated cell hyperplasia coincides with mucous (goblet) cell metaplasia after respiratory viral clearance in mouse airways. This chronic switch in epithelial behavior exhibits genetic susceptibility and depends on persistent activation of EGFR signaling to PI3K that prevents apoptosis of ciliated cells and on IL-13 signaling that promotes transdifferentiation of ciliated to goblet cells. Thus, EGFR blockade (using an irreversible EGFR kinase inhibitor designated EKB-569) prevents virus-induced increases in ciliated and goblet cells whereas IL-13 blockade (using s-IL-13Rα2-Fc) exacerbates ciliated cell hyperplasia but still inhibits goblet cell metaplasia. The distinct effects of EGFR and IL-13 inhibitors after viral reprogramming suggest that these combined therapeutic strategies may also correct ...
Cancer subtype switching, which involves unclear cancer cell origin, cell fate decision, and transdifferentiation of cells within a confined tumor microenvironment, remains a major problem in pancreatic cancer (PDA). By analyzing PDA subtypes in The Cancer Genome Atlas, we identified that epigenetic silencing of apoptosis-associated tyrosine kinase (AATK) inversely was correlated with mRNA expression and was enriched in the quasi-mesenchymal cancer subtype. By comparing early mouse pancreatic lesions, the non-invasive regions showed AATK co-expression in cells with acinar-to-ductal metaplasia, nuclear VAV1 localization, and cell cycle suppression; but the invasive lesions conversely revealed diminished AATK expression in those with poorly differentiated histology, cytosolic VAV1 localization, and co-expression of p63 and HNF1α. Transiently activated AATK initiates acinar differentiation into a ductal cell fate to establish apical-basal polarization in acinar-to-ductal metaplasia. Silenced AATK and
 Adenocarcinoma with cartilaginous and osseous metaplasia - an invasive adenocarcinoma characterized by focal or extensive cartilage and
In this study, we found that Cdx2 and Hep, especially combined analysis of these two markers are very sensitive and specific for identifying intestinal-type carcinoma, as well as being significant for understanding carcinogenesis and biological behavior, and predicting outcome of patients with gastric carcinoma.. Extensive epidemiologic investigation revealed that intestinal metaplasia increased the risk for development of gastric carcinoma, especially intestinal-type carcinoma. Intestinal metaplasia is an important precancerous lesion in the multisteps of gastric carcinoma proposed by Correa (3). Several studies to elucidate the mechanism underlying Cdx2 expression and its role have been done. The study by Silberg et al. (19) showed that gastric expression of Cdx2 alone was sufficient to induce intestinal metaplasia in mice. A recent study in Cdx2-transgenic mouse by Mutoh et al. (4) provided direct evidence that intestinal-type carcinoma could develop from intestinal metaplasia. Therefore, ...
S. M. Cazacu(1), C.C. Vere(1), N. Bodrug(2), D.I. Gheonea(1), Violeta Comanescu(3), T. Ciurea(1) (1)Department of-Gastroenterology, County Emergency Hospital Craiova, University of Medicine and Pharmacy, Craiova; (2) Department of Internal Medicine, Hospital of Chisinau, (3)Department of Pathology, Emergency University Hospital, Craiova Abstract Background &aims Gastric atrophy and intestinal metaplasia represent the most important premalignant lesions in gastric carcinogenesis (risk 1
in American Journal of Pathology (2008), 172(5), 1391-402. Epithelial metaplasia (EpM) is an acquired tissue abnormality resulting from the transformation of epithelium into another tissue with a different structure and function. This adaptative process is ... [more ▼]. Epithelial metaplasia (EpM) is an acquired tissue abnormality resulting from the transformation of epithelium into another tissue with a different structure and function. This adaptative process is associated with an increased frequency of (pre)cancerous lesions. We propose that EpM is involved in cancer development by altering the expression of adhesion molecules important for cell-mediated antitumor immunity. Langerhans cells (LCs) are intraepithelial dendritic cells that initiate immune responses against viral or tumor antigens on both skin and mucosal surfaces. In the present study, we showed by immunohistology that the density of CD1a LCs is reduced in EpM of the uterine cervix compared with native squamous epithelium and ...
It is a rare finding that is related to secondary subfertility. Less than two hundred cases have been reported in scientific literature internationally and their diagnosis may often be missed.. Mayer, a German pathologist (1901) was the first to report the presence of bony tissue in the uterus. Following that, there have also been reports by Thaler H. (1923), De Brul et al., (1956), Frydman R. και Hamou J. (1985,1991), Edwards R.G. (1985), Acharya et al., (1993). A similar case report has been published by our Unit in an international scientific journal. (Osseous Metaplasia: Case report and review, T. Lainas et al., Fertility and Sterility, Vol. 82, No 5, November 2004, 1433-1435).. Two main hypotheses have been advanced to account for such formations. The first hypothesis accounts for the majority of the cases reported and it suggests that osseous metaplasia has resulted from osseous foetal tissue that remained in the uterine cavity following an abortion that has occurred at ,3 months of ...
intestinal metaplasia in Chinese translation, English Chinese dictionary, English Chinese translation, with pronunciation, a lot of example sentences
Gastric endoscopic patterns with chromoendoscopy and magnification seem reproducible and valid for the diagnosis of lesions associated with gastric cancer. This procedure may improve the follow-up of individuals at high-risk of gastric cancer, at least for the exclusion of severe lesions.
76 Best Clinics for gastric metaplasia Treatment. ➔ ➔ ➔ The hospitals ranking is based on 15 requests, prices, and information from clinics
Of these patients, 3 underwent gastroscopy with antral and 3 body biopsies for histology according to the Sydney System.. The team found that at 7-year follow-up body atrophy and intestinal metaplasia remained unchanged in all 106 patients irrespective of H pylori status.. Antral atrophy was significantly increased at follow-up only in Group C, whereas antral intestinal metaplasia was unchanged in all 3 groups.. During follow-up, the team noted that 8% developed neoplastic lesions.. Of those that developed neoplastic lesions, 1 had adenocarcinoma, 1 had adenoma with low-grade dysplasia and 6 had low-grade dysplasia without endoscopic lesions.. The researchers observed that antral atrophic gastritis was present at baseline in all but 1 of the 8 patients with neoplastic lesions.. The team noted that antral atrophic gastritis was present only in 15 of the 98 patients without neoplastic lesions.. Dr Annibales team concludes, Atrophy and intestinal metaplasia persist at 7-year follow-up and atrophic ...
Lung - Metaplasia, Osseous from a male Wistar Han rat in a chronic study. Though this focus of osseous metaplasia (arrow) is within an area of inflammation, it is likely not treatment related ...
Since first reported EIPD in 1960, there were around 200 cases published world-wide.1,2 Up to 90% of patients with EIPD have associated oesophageal stenosis of various levels most commonly in the upper oesophagus secondary to chronic stasis oesophagitis.3,4 EIPD is often regarded as benign oesophageal disease but there are several reports where EIPD was found in patients with oesophageal carcinoma. 5 The aetiology behind EIPD developing oesophageal cancer could be due to metaplastic changes of the squamous epithelium within the excretory ducts of oesophageal submucosal glands in EIPD. 6 The pre-malignant nature of metaplastic epithelium is widely recognised in the upper gastro-intestinal tract. The increased prevalence of EIPD in patients with oesophageal carcinoma may warrant periodic surveillance in this small population of patients. ...
The H. pylori gene was present in only 6 of the 41 samples. This was expected because, when H. pylori has been present for many years and the stomach becomes atrophic and hypochlorhydric, the intragastric environment is no longer optimal for H. pylori. Competing faecal-type organisms are then able to colonise the stomach. Furthermore, H. pylori is able to colonise only normal gastric cells, and not those that have differentiated into intestinal metaplasia. Therefore, H. pylori disappears from the stomach when atrophy and intestinal metaplasia supervene. In patients who are most likely to develop gastric cancer (those with extensive intestinal metaplasia and atrophy) and those already with advanced cancer, as in our cases, the serology is often negative and the genes will almost always not be detectable by PCR.. No significant relationship was found between age and either IL-1RN or IL-1B in gastric carcinoma from Kenyan patients; the chi-square test for both was not significant: p=0.9 for IL-1RN ...
The H. pylori gene was present in only 6 of the 41 samples. This was expected because, when H. pylori has been present for many years and the stomach becomes atrophic and hypochlorhydric, the intragastric environment is no longer optimal for H. pylori. Competing faecal-type organisms are then able to colonise the stomach. Furthermore, H. pylori is able to colonise only normal gastric cells, and not those that have differentiated into intestinal metaplasia. Therefore, H. pylori disappears from the stomach when atrophy and intestinal metaplasia supervene. In patients who are most likely to develop gastric cancer (those with extensive intestinal metaplasia and atrophy) and those already with advanced cancer, as in our cases, the serology is often negative and the genes will almost always not be detectable by PCR.. No significant relationship was found between age and either IL-1RN or IL-1B in gastric carcinoma from Kenyan patients; the chi-square test for both was not significant: p=0.9 for IL-1RN ...
Chronic Obstructive Pulmonary Disease | COPD | MAPK/FoxA2-mediated cigarette smoke-induced squamous metaplasia of bronchial epithelial cells - Dove Me
foveolar metaplasia of the duodenal mucosa; duodenal foveolar metaplasia Gastric-type epithelium and islands of oxyntic mucosa in duodenal (...)
https://doi.org/10.18632/oncotarget.2041 Parama Dey, Satyanarayana Rachagani, Arokia P. Vaz, Moorthy P. Ponnusamy, Surinder K. Batra
This graph shows the total number of publications written about Metaplasia by people in this website by year, and whether Metaplasia was a major or minor topic of these publications ...
Metaplastic breast carcinomas -- analysis of prognostic factors in a case series. Nowara, Elżbieta; Drosik, Anna; Samborska-Plewicka, Marzenna; Nowara, Ewa Magdalena; Stanek-Widera, Agata // Contemporary Oncology / Wspolczesna Onkologia;2014, Vol. 18 Issue 2, p116 Aim of the study: Metaplastic breast carcinomas (MBC) are a rare group of cancers, accounting for about 1% of all breast cancers. The study presents a case series of MBC patients diagnosed, treated and followed up in one healthcare center. Material and methods: The study group comprised 18 women... ...
Wed like to send you periodic updates regarding Pathology educational materials released by our department. Youll hear about new websites, iPad apps, PathCasts, and other educational materials.. ...
en] Epithelial metaplasia (EpM) is an acquired tissue abnormality resulting from the transformation of epithelium into another tissue with a different structure and function. This adaptative process is associated with an increased frequency of (pre)cancerous lesions. We propose that EpM is involved in cancer development by altering the expression of adhesion molecules important for cell-mediated antitumor immunity. Langerhans cells (LCs) are intraepithelial dendritic cells that initiate immune responses against viral or tumor antigens on both skin and mucosal surfaces. In the present study, we showed by immunohistology that the density of CD1a LCs is reduced in EpM of the uterine cervix compared with native squamous epithelium and that the low number of LCs observed in EpM correlates with the down-regulation of cell-surface E-cadherin. We also demonstrated that transforming growth factor- 1 is not only overexpressed in metaplastic tissues but also reduces E-cadherin expression in keratinocytes ...
Disorders of epithelial ion transport play an important role in the development of many diseases such as cystic fibrosis or diarrhea. Recent research has shown that altered ion transport may also be responsible for the pathomechanism of pancreatic inflammatory diseases and for the abnormal, metaplastic changes of the esophagus (Barretts esophagus). The incidence of these diseases is increasing worldwide, placing a huge and costly burden on health-care system. At present, the pathomechanism of pancreatitis or Barretts esophagus is not completely understood, which makes it difficult to develop effective therapies. The aim of our research work is to examine the role of ion transport processes in the development and progression of these gastrointestinal diseases and to identify therapeutic targets that can be a promising starting point for treating of these diseases ...
Journal of Clinical and Diagnostic Research aims to publish findings of doctors at grass root level and post graduate students, so that all unique medical experiences are recorded in literature.
PNAS | September 12, 2017 Nguyen LP, Al-Sawalha NA, Parra S, Pokkunuri I, Omoluabi O, Okulate AA, Windham Li E, Hazen M, Gonzalez-Granado JM, Daly CJ,
TY - JOUR. T1 - Silencing of MGMT expression by promoter hypermethylation in the metaplasia-dysplasia-carcinoma sequence of Barretts esophagus. AU - Kuester, Doerthe. AU - El-Rifai, Wael. AU - Peng, Dun Fa. AU - Ruemmele, Petra. AU - Kroeckel, Ivonne. AU - Peters, Brigitte. AU - Moskaluk, Christopher A.. AU - Stolte, Manfred. AU - Mönkemüller, Klaus. AU - Meyer, Frank. AU - Schulz, Hans Ulrich. AU - Hartmann, Arndt. AU - Roessner, Albert. AU - Schneider-Stock, Regine. N1 - Funding Information: This study was supported in part by financial support for a Spitzenbonusprojekt of the Medical Faculty, Otto-von-Guericke University, Magdeburg, Germany (institutional grant to the Department of Pathology, Magdeburg) and by the National Cancer Institute Grant R01CA106176 (WER). The contents of this work are solely the responsibility of the authors and do not necessarily represent the official views of the National Cancer Institute, Vanderbilt University or University of Magdeburg. The authors thank ...
TY - JOUR. T1 - Mucinous metaplasia of the prepuce - A case report and review of literature - A case report. AU - Mathew, Mary. AU - Joshi, Anurag. AU - Roy, Alfred. PY - 2006/4/1. Y1 - 2006/4/1. N2 - Benign mutinous metaplasia of the prepuce is a rare and under recognized entity which can easily be mistaken for extramammary Pagets disease. It is characterized by the presence of benign mucin containing cells in the squamous epithelium. To the best of our knowledge only 6 such cases have been documented in the literature. We would like to report the first case in our country.. AB - Benign mutinous metaplasia of the prepuce is a rare and under recognized entity which can easily be mistaken for extramammary Pagets disease. It is characterized by the presence of benign mucin containing cells in the squamous epithelium. To the best of our knowledge only 6 such cases have been documented in the literature. We would like to report the first case in our country.. UR - ...
TY - JOUR. T1 - Matrix metalloproteinase-7 is expressed by pancreatic cancer precursors and regulates acinar-to-ductal metaplasia in exocrine pancreas. AU - Crawford, Howard C.. AU - Scoggins, Charles R.. AU - Kay Washington, M.. AU - Matrisian, Lynn M.. AU - Leach, Steven D.. PY - 2002. Y1 - 2002. N2 - In gastrointestinal epithelium, metaplastic conversion between predominant cell types is associated with an increased risk of neoplasia. However, the mechanisms regulating metaplastic transitions in adult epithelia are largely undefined. Here we show that matrix metalloproteinase-7 (MMP-7) is expressed not only in the majority of human pancreatic ductal adenocarcinoma specimens, but also in human pancreatic intraepithelial neoplasia and metaplastic duct lesions in human and mouse. In a mouse model of pancreatic acinar-to-ductal metaplasia, MMP-7 progressively accumulates during the metaplastic transition, resulting in a concomitant increase in solubilization of Fas ligand (FasL). Under identical ...
Carnivorous reptiles are not usually thought of as being prone to metabolic bone disorders. A constant diet lacking in calcium or bone and/or high in phosphorus or low in vitamin D3 can lead to this nutritional disorder in certain situations. Nile monitor lizards are carnivorous lizards native to Africa and common in the pet trade and as display animals in zoos. They normally consume whole vertebrate prey but will readily take muscle and organ offerings. This is a case of a Nile monitor that suffered fibrous osteodystrophy and chondroid metaplasia after being fed mostly muscle tissue for over two years. Once the diet was corrected the clinical signs resolved.. ...
AIM: To determine associations between enterogastric bile reflux and gastric mucosal pathology. METHOD: A retrospective study using fasting gastric juice bile acid measurements and antral or prestomal biopsy specimens from 350 patients, 66 of whom had previously undergone surgery that either bypassed or disrupted the pyloric sphincter. RESULTS: Bile reflux was positively associated with reactive gastritis and negatively with Helicobacter pylori density. After stratification for previous surgery, age, and H pylori status, the histological feature most strongly associated with bile reflux was intestinal metaplasia, including all its subtypes. The prevalence of intestinal metaplasia was greatest in patients with both H pylori infection and high bile acid concentrations. Bile reflux was also positively associated with the severity of glandular atrophy, chronic inflammation, lamina propria oedema and foveolar hyperplasia. CONCLUSIONS: Bile reflux is a cause of reactive gastritis. It modifies the ...
TY - JOUR. T1 - Coexistence of gastric- and intestinal-type endocrine cells in gastric and intestinal mixed intestinal metaplasia of the human stomach. AU - Otsuka, Takafumi. AU - Tsukamoto, Tetsuya. AU - Mizoshita, Tsutomu. AU - Inada, Ken Ichi. AU - Takenaka, Yoshiharu. AU - Kato, Sosuke. AU - Yamamura, Yoshitaka. AU - Miki, Kazumasa. AU - Tatematsu, Masae. PY - 2005/4/1. Y1 - 2005/4/1. N2 - Intestinal metaplasia (IM) in the human stomach has previously been classified into a gastric and intestinal mixed (GI-IM) and a solely intestinal phenotype (I-IM). The phenotypes of mucous and endocrine cells were evaluated in 3034 glandular ducts associated with chronic gastritis. In the pyloric region, the relative expression of gastric endocrine cell markers, such as gastrin and somatostatin, decreased gradually from glandular ducts with only gastric mucous cell phenotype (G type) to GI-IM toward I-IM, while that of the intestinal endocrine cell markers, glicentin, gastric inhibitory polypeptide (GIP), ...
Metaplasia is the replacement of one differentiated somatic cell type with another differentiated somatic cell type in the same tissue. Typically, metaplasia is triggered by environmental stimuli, which may act in concert with the deleterious effects of microorganisms and inflammation. The cell of origin for intestinal metaplasia in the oesophagus and stomach and for pancreatic acinar-ductal metaplasia has been posited through genetic mouse models and lineage tracing but has not been identified in other types of metaplasia, such as squamous metaplasia. A hallmark of metaplasia is a change in cellular identity, and this process can be regulated by transcription factors that initiate and/or maintain cellular identity, perhaps in concert with epigenetic reprogramming. Universally, metaplasia is a precursor to low-grade dysplasia, which can culminate in high-grade dysplasia and carcinoma. Improved clinical screening for and surveillance of metaplasia might lead to better prevention or early ...
Danahay, Henry and Pessotti, Angelica and Coote, Julie and Montgomery, Brooke and Xia, Donghui and Wilson, Aaron and Yang, Haidi and Wang, Zhao and Bevan, Luke and Thomas, Chris and Petit, Stephanie and London, Anne and Lemotte, Peter and Doelemeyer, Arno and Velez-Reyes, German and Bernasconi, Paula and Fryer, Christy and Edwards, Matthew and Capodieci, Paola and Chen, Amy and Hild, Marc and Jaffe, Aron (2015) Notch2 is required for inflammatory cytokine-driven goblet cell metaplasia in the lung. Cell Reports. ...
The molecular pathogenesis of Barretts metaplasia (BM) of the esophagus is poorly understood. The change to an intestinal phenotype occurs on a background of esophagitis due to refluxing acid and bile. CDX1, an important regulator of normal intestinal development, was studied as a potential key molecule in the pathogenesis of BM. CDX1 mRNA and protein were universally expressed in all samples of BM tested but not in normal esophageal squamous or gastric body epithelia. This tissue-specific expression was attributable to the methylation status of the CDX1 promoter. Conjugated bile salts and the inflammatory cytokines TNF-alpha and IL-1beta were all found to increase CDX1 mRNA expression in vitro. These effects were primarily mediated by NF-kappaB signaling but only occurred when the CDX1 promoter was unmethylated or partially methylated. The data suggest that CDX1 is a key molecule linking etiological agents of BM to the development of an intestinal phenotype. Although the initial trigger for CDX1
ORCID: 0000-0003-2130-9181, Provenzale, Dawn and Moayyedi, Paul (2002) Esophageal adenocarcinoma arising from Barretts metaplasia has regional variations in the west. Gastroenterology, 122 (2). pp. 588-590. ISSN 0016-5085 Full text not available from this repository.. Official URL: http://dx.doi.org/10.1053/gast.2002.31599. ...
In this study, we aimed to investigate the characteristics of the duodenal mucosal microbiota of patients with intestinal metaplasia (IM) and compare it with those of the gastric mucosal microbiota. We collected the duodenal and gastric mucosal samples from 10 adult patients with IM and 10 healthy controls (HC). The V3-V4 region of the bacterial 16S rRNA gene was examined by high throughput sequencing method. The diversity of the HC duodenal microbiota was higher than that of IM patient based on the Shannon and Simpson index while the Chao indices of IM duodenal mucosal microbiota was significantly higher than that of gastric mucosal microbiota of patients with IM. There was a marked difference in the duodenal microbiota structure between patients with IM and HC (ANOSIM, R = 1, P = 0.001). We also found that the Helicobacter pylori infection in gastric mucosa did not influence the structure of duodenal mucosal microbiota. The gastric mucosal microbiota structure significantly differed between patients
TY - JOUR. T1 - Expression of small intestinal and colonic phenotypes in complete intestinal metaplasia of the human stomach. AU - Tanaka, Harunari. AU - Tsukamoto, Tetsuya. AU - Mizoshita, Tsutomu. AU - Inada, Ken Ichi. AU - Ogasawara, Naotaka. AU - Cao, Xueyuan. AU - Kato, Sosuke. AU - Joh, Takashi. AU - Tatematsu, Masae. N1 - Funding Information: Acknowledgements This study was supported in part by a Grant-in-Aid for the Third-term Comprehensive 10-year Strategy for Cancer Control and a Grant-in-Aid for Cancer Research from the Ministry of Health, Labour and Welfare, Japan, and a Grant-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology of Japan. The authors thank Dr. Malcolm A. Moore for revision of the scientific English language and Ms. Hisayo Ban for expert technical assistance. The anti-sucrase antibody was a generous gift from Dr. Kazuyuki Hirano, Department of Pharmaceutics, Gifu Pharmaceutical University, Gifu, Japan.. PY - 2005/11. Y1 - 2005/11. N2 - The ...
TY - JOUR. T1 - A longitudinal study of the JAK2V617F mutation in myelofibrosis with myeloid metaplasia. T2 - Analysis at two time points. AU - Mesa, Ruben A.. AU - Powell, Heather. AU - Lasho, Terra. AU - DeWald, Goron W.. AU - McClure, Rebecca. AU - Tefferi, Ayalew. PY - 2006/3/1. Y1 - 2006/3/1. N2 - Serial analysis for the activating JAK2V617F mutation performed in 44 patients with myelofibrosis with myeloid metaplasia showed no interval change in 88% (22/25) of patients over a median interval of 18.6 months. The increase in JAK2 expression observed in three patients did not correspond to disease progression or leukemic transformation.. AB - Serial analysis for the activating JAK2V617F mutation performed in 44 patients with myelofibrosis with myeloid metaplasia showed no interval change in 88% (22/25) of patients over a median interval of 18.6 months. The increase in JAK2 expression observed in three patients did not correspond to disease progression or leukemic transformation.. KW - ...
Chronic inflammation with mucous metaplasia and airway remodeling are hallmarks of allergic asthma, and these outcomes have been associated with enhanced expression and activation of EGFR signaling. Here, we demonstrate enhanced expression of EGFR ligands such as amphiregulin as well as constitutive EGFR activation in cultured nasal epithelial cells from asthmatic subjects compared with nonasthmatic controls and in lung tissues of mice during house dust mite-induced (HDM-induced) allergic inflammation. EGFR activation was associated with cysteine oxidation within EGFR and the nonreceptor tyrosine kinase Src, and both amphiregulin production and oxidative EGFR activation were diminished by pharmacologic or genetic inhibition of the epithelial NADPH oxidase dual oxidase 1 (DUOX1). DUOX1 deficiency also attenuated several EGFR-dependent features of HDM-induced allergic airway inflammation, including neutrophilic inflammation, type 2 cytokine production (IL-33, IL-13), mucous metaplasia, ...
TY - JOUR. T1 - Acidic Bile Salts Induce Epithelial to Mesenchymal Transition via VEGF Signaling in Non-Neoplastic Barretts Cells. AU - Zhang, Qiuyang. AU - Agoston, Agoston T.. AU - Pham, Thai H.. AU - Zhang, Wei. AU - Zhang, Xi. AU - Huo, Xiaofang. AU - Peng, Sui. AU - Bajpai, Manisha. AU - Das, Kiron. AU - Odze, Robert D.. AU - Spechler, Stuart J.. AU - Souza, Rhonda F.. PY - 2019/1/1. Y1 - 2019/1/1. N2 - Background & Aims: Metaplastic glands buried under squamous epithelium are frequently detected in patients with Barrett esophagus (BE). This subsquamous intestinal metaplasia might be responsible for cancers that develop despite endoscopic surveillance and for metaplasia recurrences after endoscopic ablation. To determine whether reflux induces BE cells to undergo an epithelial-to-mesenchymal transition (EMT) that produces subsquamous intestinal metaplasia, we assessed EMT in BE cells exposed to acidic bile salts and in rat and human esophageal tissues. Methods: We compared markers of EMT ...
The first step in treatment is getting a diagnosis. Because Barretts esophagus doesnt lead to any noticeable symptoms, its more likely that the doctor will notice the condition while checking for a related acid reflux condition. To diagnose the condition, doctors do something called an endoscopy. This is essentially a procedure where the doctor will push a small, flexible camera down the esophagus to do a visual inspection of the damage.. The doctor will then take a small biopsy of tissue from the esophagus and examine the tissue under a microscope to see if metaplasia has occurred. Once youve got a diagnosis, there are a few ways to treat the condition.. The first step is to minimize the risk of cancer. This usually involves basic treatments for acid reflux and lifestyle changes to reduce risk. Things like smoking and alcohol use are not only a significant factor in acid reflux but can raise your risk of cancer. By making changes to these habits and your diet, you can help reduce the amount ...
Blood analysis revealed a leukocytosis (29370/mm3) with neutrophilia (23202/mm3). Low-dose dexamethasone test definitely excluded Cushing disease (basal cortisol levels 2,17 µg/dl; cortisol at 4 and 8 hours , 1 µg/dl). A prostatic wash was performed and revealed a severe prostatitis and presence of keratinized prostatic cells, indicating a squamous metaplasia of the prostate. Measurement of seric LH levels (LH Witness®, Synbiotics) showed an LH concentration lower than 1 ng/ml, indicating a hormonal negative feedback on the hypothalamo-hypophyso-gonadal axis ...
During the EGD, Barrett esophagus is diagnosed. Omeprazole is taken following the surgery. Without parietal cells, how does PPI work?(or some metaplastic cell have acid secreting function which can be suppressed by PPI?) Would EGD increase the risk of bile reflux and aggravate metaplasia?....:dead ...
Idiopathic generalized myelofibrosis with myeloid metaplasia is a disease of unknown etiology in which the clinical and morphologic manifestations vary greatly even during the course of an individual case. The resulting confusion has led to an undue number of synonyms, each of which tends to focus on a single aspect of the disease. Many cases exhibit panhyperplasia of all bone marrow elements including fibroblasts, although eventually the more characteristic picture of fibrosis may predominate. Myeloid metaplasia is a constant and persistent finding, even when the bone marrow is hypercellular. A leukoerythroblastic peripheral blood picture is usually present at some time ...
Male and female breeder rats spontaneously develop arteriosclerosis. This occurs first in the aorta and coronary arteries and subsequently in the carotid and intracranial arteries. The carotid arteries show mesenchymal cell proliferation in the media followed by subintimal swelling and mucoid deposition, elastosis, cartilaginous metaplasia and eventual bone formation. Lipid deposition occurs infrequently, and then only in advanced lesions in the media. Severe lesions are much more frequent in the female breeder and the tendency towards cartilaginous metaplasia and bone formation is peculiar to the carotid arteries. The cerebral arteries show little arteriosclerotic involvement except for aneurysm-like outpouchings of the internal elastic membrane associated with mucopolysaccha-ride accumulation about the sites of elastic tissue disruption. Despite severe fulminating arteriosclerosis in the carotid arteries, the cerebral arteries and the brain tissue itself show little or no significant evidence ...
Burgel, P., and Nadel, J. (2004). Roles of epidermal growth factor receptor activation in epithelial cell repair and mucin production in airway epithelium. Thorax 59, 992-996.. Casalino-Matsuda, S., Monzón, M., and Forteza, R. (2006). Epidermal Growth Factor Receptor Activation by Epidermal Growth Factor Mediates Oxidant-Induced Goblet Cell Metaplasia in Human Airway Epithelium. Am J Respir Cell Mol Biol 34, 581-591.. Curran, D., and Cohn, L. (2010). Advances in mucous cell metaplasia: a plug for mucus as a therapeutic focus in chronic airway disease. Am J Respir Cell Mol Biol 42, 268-275.. Gao, W., Li, L., Wang, Y., Zhang, S., Adcock, I.M., Barnes, P.J., Huang, M., and Yao, X. (2015). Bronchial epithelial cells: The key effector cells in the pathogenesis of chronic obstructive pulmonary disease? Respirology 20, 722-729.. Hennessy, B.T., Smith, D.L., Ram, P.T., Lu, Y. and Mills, G.B., 2005. Exploiting the PI3K/AKT pathway for cancer drug discovery. Nat Rev Drug Discov 4, 988-1004.. Øvrevik, ...
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Supine duodeno-gastro-oesophageal bile reflux measured with the Bilitec-2000 appears to protect against the presence of microscopic intestinal metaplasia at the cardia Conference Paper ...
Published in the Journal of PLoS One http://www.ncbi.nlm.nih.gov/pubmed/23308100 Abstract: We examined whether colonization of selected oral pathogens is associated with gastric precancerous lesions in a cross-sectional study. A total of 119 participants were included, discount viagra of which 37 were cases of chronic atrophic gastritis, intestinal metaplasia, or dysplasia. An oral examination was performed to […]. ...
Numerous reviews and guidelines encourage us to undertake surveillance of patients with Barretts oesophagus (BO). Despite this, many experienced gastroenterologists consider there is insufficient evidence to support this approach. The definition of what constitutes BO remains an issue and is an important element of critically analysing reports. The previous idea that patients could be selected by the length of the Barrets segment (,3 cm) appears incorrect as it does not have a major influence on the subsequent risk of carcinoma.1 The presence of intestinal metaplasia (IM) is important in the pathogenesis of cancer development but the absolute requirement to identify an area of IM before making a diagnosis of BO appears irrational. This is because virtually all patients with a columnar lined oesophagus also have some IM if enough biopsies are taken.2. Depending on the definition, 0.25-2% of the general population have BO.3,4 The introduction of surveillance for this huge number would therefore ...
This suggests that the influx of inflammatory cells during the metaplasia to BE is not mainly caused by an inflammatory http://www.selleckchem.com/products/chir-99021-ct99021-hcl.html process but in fact is the consequence of alterations due to the metaplastic tissue more resembling duodenal tissue. Further studies on the role of these ��intestinal�� lymphocytes in BE may result in a better understanding of the pathogenesis and/or prognosis of BE. Materials and Methods Patient characteristics Fifty-nine patients were included in our study. Of these, 41 patients had BE, as defined by the presence of specialised intestinal metaplasia (IM) containing goblet cells in at least one of the biopsies.. Eleven patients were excluded from the BE group due to the presence of macroscopic esophagitis (ulcers and erosions) proximal to the Barretts segment (n=1), BE segments being smaller then C0M2 because of the risk of biopsying squamous esophageal epithelium or gastric tissue instead of BE tissue ...
Synonyms for mucus cell in Free Thesaurus. Antonyms for mucus cell. 24 synonyms for cell: room, chamber, lock-up, compartment, cavity, cubicle, dungeon, stall, unit, group, section, core, nucleus, caucus, coterie, electric cell. What are synonyms for mucus cell?
TY - JOUR. T1 - LA LASER-CITOFLUORIMETRIA A FLUSSO NELLO STUDIO DELLE LESIONI INDOTTE DA PAPILLOMAVIRUS. AU - Altomare, G. F.. AU - Pigatto, P. D.. AU - Capella, G. L.. AU - Finzi, A. F.. PY - 1990. Y1 - 1990. N2 - HPV insertion into the genome can cause permanent changes in cellular DNA that disturb the regulation of cell proliferation. Most HPV-induced epithelial proliferative disease are benign, but not all. We have studied both types of lesion by automated laser flow cytometry to see if there were any permanent changes in the DNA that might serve as reliable prognostic indicators. There were 101 lesions of interest to the dermatologist, stomatologist and gynecologist. Although fluctuations in yields of cells make it difficult to formulate definite conclusions, since many results are heterogeneous and hard to summarize, we found dysplastic and metaplastic lesions always to be hyper- or hypodiploid and to our surprise two cases of common wart were hyperdisploid and another hypodiploid. This ...
Department of Biology and Biochemistry, University of Bath. Dr David Tosh leads the Vertebrate Embryonic Development research group at the Department of Biology and Biochemistry , University of Bath. His lab is interested in the phenomenon of transdifferentiation (sometimes referred to as metaplasia). Transdifferentiation is defined as the conversion of one differentiated cell type to another. It belongs to a wider class of cell type conversions known as metaplasias that include conversions between stem cell types.. The Tosh group has developed a number of models for the transdifferentiation of pancreas to liver and the reverse. They use their studies of transdifferentiation and metaplasia to help: ...
Over the past three to four decades, esophageal adenocarcinoma (EAC) incidence has increased dramatically in the Western world due to causes that are not well understood. Current screening strategies for early detection aim to identify individuals with Barretts esophagus (BE), an intestinal metaplasia that develops in the ...
We have examined the cell surface molecule CD44, which is attracting interest because of reports that isoforms are associated with metastasis. The prognostic value of CD44 expression has yet to be assessed for a solid tumour. Benign (59) and malignant (primary 61, metastatic 59) gastric tissues were examined with antibodies directed at epitopes common to known CD44 isoforms. Normal mucosa was CD44 negative. In atrophic gastritis and intestinal metaplasia expression was restricted to the epithelial cells of the basal glands and was positively correlated with an increased leucocyte infiltrate and with the expression of HLA DR by mucosal cells. These observations suggest a role for chronic inflammation in the induction of CD44 expression on benign mucosa. No such association was observed between inflammatory infiltrate and CD44 expression on gastric tumours. CD44 expression, observed in only 49% of primary tumours, was associated with distant metastases at time of diagnosis and, among 31 curatively ...
Tytu : Serum adiponectin, resistin, leptin concentration and central adiposity parameters in Barretts esophagus patients with and without intestinal metaplasia in comparison to healthy controls and patients with GERD ...
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Results The histological features include epithelial hyperplasia (21.1%), surface ulceration (2.2%), goblet cells (62.2%), squamous metaplasia (11.1%), active fibrosis (31.1%), severe inflammation (8.9%), multinucleated giant cells (3.3%), stromal calcification (8.9%) and active proliferating vessels (5.6%). Among these histological features, patients with either hyperplasia or calcification in their excised corneal pannus show an unfavourable outcome compared with patients without hyperplasia (p=0.003) or calcification (p=0.018). A similar unfavourable outcome was not seen with other histological features and various clinical parameters.. ...
Symptoms and treatment alternatives in cystitis, acute or chronic cystitis, interstitiel cystitis, squamous metaplasia, tuberculosis, nephritis
Precancerous lesions are areas of tissue with abnormally rapid cell growth. Though many precancerous lesions can be treated, if...
The standard treatment for patients with gastric low-grade dysplasia (LGD) remains controversial, even though diagnosis of LGD is increasingly common as esophagogastrodeuodenoscopy becomes more available. The aim of this study was to identify a lesio
Barton T. Barrett, DMD is a practicing Dentist in Ardmore, TN. Dr. Barrett accepts multiple insurance plans including Aetna, Dental Network of America and ...
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Intestinal metaplasia[edit]. The presence of goblet cells, called intestinal metaplasia, is necessary to make a diagnosis of ... The presence of intestinal metaplasia in Barrett's esophagus represents a marker for the progression of metaplasia towards ... Colonic metaplasia is usually identified by finding goblet cells in the epithelium and is necessary for the true diagnosis.[ ... The metaplasia is grossly visible through a gastroscope, but biopsy specimens must be examined under a microscope to determine ...
Main article: Metaplasia. Apocrine metaplasia is a reversible transformation of cells to an apocrine phenotype. It is common in ... This type of metaplasia represents an exception to the common rule of metaplasia increasing the risk for developing cancer; ... Metaplasia happens when there is an irritation to the breast (breast cyst). Apocrine-like cells form in a lining of developing ... Apocrine metaplasia of the breast.http://radiopaedia.org/articles/apocrine-metaplasia-of-the-breast ...
"Nephrogenic metaplasia". Pathology Outlines. Retrieved 22 October 2016. CS1 maint: discouraged parameter (link) Peeker R ...
"Intraocular osseous metaplasia. A clinico-pathological study". Indian J Ophthalmol. 50 (3): 183-8. PMID 12355691.CS1 maint: ...
Endometriosis Metaplasia Bermejo, Rosa; Gómez, Alicia; Galiana, Nuria; Campos, Antonio; Puente, Rebeca; Bas, Ernesto; Díaz- ...
Metaplasia Squamous. Glandular. Cell death. Necrosis Coagulative necrosis. Liquefactive necrosis. Gangrenous necrosis. Caseous ...
Metaplasia Squamous. Glandular. Cell death. Necrosis Coagulative necrosis. Liquefactive necrosis. Gangrenous necrosis. Caseous ... Prior to the abnormal growth of tissue, as neoplasia, cells often undergo an abnormal pattern of growth, such as metaplasia or ... dysplasia.[6] However, metaplasia or dysplasia does not always progress to neoplasia.[1] The word is from Ancient Greek νέος- ...
The reversible transformation of cells of one differentiated cell type to another is called metaplasia. This transition can be ... Slack, J. M. W. (2009). "Metaplasia and somatic cell reprogramming". The Journal of Pathology. 217 (2): 161-8. doi:10.1002/path ...
An example of PAS-D in use is in showing gastric/duodenal metaplasia in duodenal adenomas. PAS diastase stain is also used to ... Periodic acid-Schiff stain Diastase Rubio CA (2007). "Gastric duodenal metaplasia in duodenal adenomas". J. Clin. Pathol. 60 (6 ...
Fukunaga M(2000). Smooth muscle metaplasia in ovarian endometriosis. Histopathology 36(4):348-352. Fujii S, Konishi I, Mori T ( ... Anyway, the phenomenon of smooth muscle cell metaplasia occurring in association with endometriosis (endomyometriosis), as well ...
The disease was also known as myelofibrosis with myeloid metaplasia and agnogenic myeloid metaplasia The World Health ... 2010). "The role of splenectomy in myelofibrosis with myeloid metaplasia". Minerva Chirurgica. 65 (6): 619-25. PMID 21224796. " ... Lichtman MA (July 2005). "Is it chronic idiopathic myelofibrosis, myelofibrosis with myeloid metaplasia, chronic megakaryocytic ... Tefferi, Ayalew (2003). "The Forgotten Myeloproliferative Disorder: Myeloid Metaplasia". The Oncologist. 8 (3): 225-231. doi: ...
GERD may lead to Barrett's esophagus, a type of intestinal metaplasia,[13] which is in turn a precursor condition for ... Barrett's esophagus - intestinal metaplasia (changes of the epithelial cells from squamous to intestinal columnar epithelium) ...
Metaplasia, however, aligns more closely with transdifferentiation, because metaplasia refers more to the idea of a phenotypic ... Metaplasia refers to the change from a fully differentiated cell type to another. This implies that the cell is able to adapt ... The idea of metaplasia depends on the ability for a cell to dedifferentiate. This definition is important to consider when ... Metaplasia [13] is not another definition of dedifferentiation, but the two words have very similar implications for cells. ...
Squamous metaplasia of breast epithelia is known to be more prevalent in postmenopausal women (where it does not cause any ... Squamous metaplasia of lactiferous ducts - abbreviated SMOLD is a change where the normal double layer cuboid epithelium of the ... Further uncertainty in the relation of SMOLD and the subareolar abscess is that squamous metaplasia is very often caused by ... It is a frequently aseptic inflammation and has been associated with squamous metaplasia of lactiferous ducts. The term is ...
Adenocarcinoma of the stomach and intestinal metaplasia. H&E stain. If cancer cells are found in the tissue sample, the next ... Tsukamoto T, Mizoshita T, Tatematsu M (2006). "Gastric-and-intestinal mixed-type intestinal metaplasia: aberrant expression of ... and intestinal metaplasia. To find the cause of symptoms, the doctor asks about the patient's medical history, does a physical ... it associates intestinal metaplasia in neighbouring mucosa. Depending on glandular architecture, cellular pleomorphism and ...
subareolar abscess and squamous metaplasia of lactiferous ducts. *most forms of fibrocystic breast changes and cysts are ...
"Visceral Nodular Cartilaginous Metaplasia in Rockfishes (Sebastes Spp.) in the Eastern North Pacific Ocean." Journal of ... discrete nodules of cartilaginous metaplasia. Like other rockfish, yellowmouth rockfish have swim bladders that are unable to ...
Spechler SJ, Goyal RK (February 1996). "The columnar-lined esophagus, intestinal metaplasia, and Norman Barrett". ...
In 2018, Merchant was awarded additional NIH funding to study "MDSC Polarization and Helicobacter-Induced Gastric Metaplasia;" ... "1R01DK118563-01, MDSC POLARIZATION AND HELICOBACTER-INDUCED GASTRIC METAPLASIA". projectreporter.nih.gov. Retrieved 2020-06-10 ...
Slack, J.M.W. (2007). "Metaplasia and transdifferentiation: from pure biology to the clinic". Nature Reviews Molecular Cell ... Casimir CM, Gates PB, Patient RK, Brockes JP (1988-12-01). "Evidence for dedifferentiation and metaplasia in amphibian limb ...
"CDX1 is an important molecular mediator of Barrett's metaplasia". Proceedings of the National Academy of Sciences of the United ... with special emphasis on participation in intestinal metaplasia of the human stomach". Gastric Cancer. 4 (4): 185-91. doi: ...
Intestinal metaplasia is classified histologically as complete or incomplete. With complete metaplasia, gastric mucosa is ... Intestinal metaplasia typically begins in response to chronic mucosal injury in the antrum and may extend to the body. Gastric ... Mucous gland metaplasia, the reversible replacement of differentiated cells, occurs in the setting of severe damage of the ... In incomplete metaplasia, the epithelium assumes a histologic appearance closer to that of the large intestine and frequently ...
This mode of bone formation is identified as metaplasia. Osteoderms are not historically uniform but include a mix of tissues, ...
Yadav UC, Aguilera-Aguirre L, Ramana KV, Boldogh I, Srivastava SK (2010). "Aldose reductase inhibition prevents metaplasia of ... root pathology modulating treatment for asthma and COPD since it has been shown that they inhibit goblet cell metaplasia in the ...
Areas of squamous metaplasia and epithelial pearls may be present. The tumor is not enveloped, but it is surrounded by a ...
"Notch signaling promotes airway mucous metaplasia and inhibits alveolar development". Development. 136 (10): 1751-1759. doi: ...
... into neck cells and can lead to the formation of mucus cell metaplasia known as spasmolytic polypeptide expressing metaplasia ( ... "The origin of pre-neoplastic metaplasia in the stomach: chief cells emerge from the Mist". Experimental Cell Research. 317 (19 ... "Mature chief cells are cryptic progenitors for metaplasia in the stomach". Gastroenterology. 139 (6): 2028-2037.e9. doi ...
Gastric cancer develops within areas (field defects) of the stomach with atrophic gastritis and intestinal metaplasia: these ... O'Connor, A; McNamara, D; O'Moráin, CA (Sep 23, 2013). "Surveillance of gastric intestinal metaplasia for the prevention of ... is confirmed by a metaplastic change of the esophageal mucosa from squamous to columnar mucosa with intestinal metaplasia. ...
Interleukin-13 has a critical role in the Goblet cell metaplasia. Goblet cells are filled with mucin (MUC). MUC5AC Mucin 5AC is ... goblet cell metaplasia, mucus hypersecretion and airway remodelling which all contribute to airway obstruction. murine studies ...
The tongue of Agalychnis lemur is prominently affected by squamous metaplasia. Other associated problems occur elsewhere, such ... with a very small number contracting lungworm infection and squamous metaplasia. A stumbling block to the conservation of ...
If the stimulus causing metaplasia is removed or ceases, tissues return to their normal pattern of differentiation. Metaplasia ... squamous metaplasia). Metaplasia is an adaptation that replaces one type of epithelium with another that is more likely to be ... Metaplasia Squamous. Glandular. Cell death. Necrosis Coagulative necrosis. Liquefactive necrosis. Gangrenous necrosis. Caseous ... Metaplasia (Greek: "change in form") is the transformation of one differentiated cell type to another differentiated cell type ...
A person can prevent intestinal metaplasia by avoiding risk factors, such as smoking and poor diet. ... Intestinal metaplasia is a condition where the cells lining the stomach transform into cells that resemble those found in the ... Some doctors consider intestinal metaplasia to be a precancerous condition.. Intestinal metaplasia is more common in people who ... Intestinal metaplasia can be severe. The transformation of the cells of the gastric lining puts a person at a much higher risk ...
We present the case of a dedifferentiated paratesticular liposarcoma with osseous metaplasia of the spermatic cord, in a male ... Dedifferentiated Paratesticular Liposarcoma with Osseous Metaplasia,. Case Reports in Urology,. vol. 2015. ,. Article ID ... The osseous metaplasia was not considered to confer any aggressiveness to the tumor. The radiologic evaluation was negative for ... Osseous metaplasia is rare and does not represent an unfavorable prognostic factor. However, these tumors, due to their ...
I had an upper endoscopy and the pathology report shows I have focal intestinal metaplasia. The doctor did not even tell me. I ... I was diagnosed with goblet cell metaplasia one and -a half years ago. Dr. was supposed to call after the biopsy came back ,but ... I had an upper endoscopy and the pathology report shows I have focal intestinal metaplasia. The doctor did not even tell me. I ... Im upset because what I read online about focal intestinal metaplasia is that it is a pre-cancerous condition and a high risk ...
Squamous metaplasia definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look ... squamosal, squamous, squamous cell, squamous cell carcinoma, squamous epithelium, squamous metaplasia, squamous metaplasia of ...
Lenalidomide therapy in myelofibrosis with myeloid metaplasia.. Tefferi A1, Cortes J, Verstovsek S, Mesa RA, Thomas D, Lasho TL ... in a total of 68 patients with symptomatic myelofibrosis with myeloid metaplasia (MMM). Protocol treatment consisted of oral ...
Intestinal metaplasia Squamous metaplasia Micrograph of Barretts esophagus, an example of glandular metaplasia. "Metaplasia". ... Glandular metaplasia is a type of metaplasia where irritated tissue converts to a glandular form. An example occurs in the ... CS1 maint: discouraged parameter (link) Ward AM (July 1971). "Glandular metaplasia and mucin production in transitional cell ...
cartilaginous metaplasia synonyms, cartilaginous metaplasia pronunciation, cartilaginous metaplasia translation, English ... dictionary definition of cartilaginous metaplasia. adj. 1. Of, relating to, or consisting of cartilage. 2. Having a skeleton ... redirected from cartilaginous metaplasia). Also found in: Thesaurus, Medical. car·ti·lag·i·nous. (kär′tl-ăj′ə-nəs). adj.. 1. Of ... 7) Some authors make a distinction between a primary form, which represents an active cartilaginous metaplasia, and a secondary ...
... Yoshihisa Nakamura,1 Yuki Hamajima,1 Masahiro Komori,2 Makoto Yokota,1 Motohiko ... An infection of whipworm (Trichuris muris) in the mouse intestine is reported to induce mucous cell metaplasia where Math1 is ... 1. Mucous Cell Metaplasia in Intractable Otitis Media. One of the most characteristic features of intractable otitis media is ... Y. Tsuboi, Y. Kim, G. S. Giebink et al., "Induction of mucous cell metaplasia in the middle ear of rats using a three-step ...
Metaplasia refers to normal growth and repair of cells and usually does... ... Squamous metaplasia is a normal condition that sometimes requires further testing, according to the University of Pennsylvania ... Cervical metaplasia is detected by a pap smear test. More than half of women have metaplasia at some point, the University of ... Squamous metaplasia is also commonly found in the bladder, Wikipedia notes. Smokers sometimes show squamous metaplasia in their ...
In the first stage of intestinal metaplasia, the patients damaged esophageal lining begins to grow the type of cells that line ... In the first stage of intestinal metaplasia, the patients damaged esophageal lining begins to grow the type of cells that line ... Doctors believe the process of intestinal metaplasia begins in response to gastroesophageal reflux, states Johns Hopkins ...
JAK2(V617F) and leukemic transformation in myelofibrosis with myeloid metaplasia.. Mesa RA1, Powell H, Lasho T, Dewald G, ... Amongst 42 consecutive patients with leukemic transformation (LT) from myelofibrosis with myeloid metaplasia (MMM) 72% carried ...
In the stomach, chronic inflammation causes metaplasia and creates a favorable environment for the evolution of gastric cancer ... and spasmolytic polypeptide-expressing metaplasia (SPEM), a putative precursor of gastric cancer. SPEM and oxyntic atrophy ... for endogenous glucocorticoid signaling within the stomach to prevent spontaneous gastric inflammation and metaplasia, and ...
Osseous metaplasia may vary in size, and hematopoietic cells may be present in larger lesions ( Figure 1. and Figure 2. ). ... Kidney - Metaplasia, Osseous in a male B6C3F1 mouse from a chronic study. An area of mature bone is present in the cortex. ... Osseous metaplasia is characterized by mature-appearing bone in the renal parenchyma. It is usually noted as a focal lesion in ... Kidney - Metaplasia, Osseous in a female B6C3F1 mouse from a chronic study. An area of mature bone and associated hematopoietic ...
Early squamous metaplasia, where only the surface cells are flattened, can be difficult to identify. Squamous metaplasia should ... Squamous metaplasia of the alveolar epithelium ( Figure 1. , Figure 2. , Figure 3. , Figure 4. , Figure 5. , Figure 6. , Figure ... more than one layer of cells is present in squamous metaplasia. Squamous metaplasia can be seen as a response to chronic ... Lung, Bronchiole - Metaplasia, Squamous in a male F344/N rat from an acute study. The normal bronchiolar epithelium has been ...
Myeloid metaplasia does not occur in aplastic disease. Thus, its presence in a patient who is anemic suggests bone marrow ... encoded search term (What does the presence of myeloid metaplasia suggest in the workup of anemia?) and What does the presence ... What does the presence of myeloid metaplasia suggest in the workup of anemia?. Updated: Oct 08, 2018 ... The diagnosis of myelofibrosis or neoplastic involvement of bone marrow is often suggested by evidence of myeloid metaplasia in ...
... metaplasia in English->English dictionary. Search nearly 13 million words and phrases in more than 460 language pairs. ... Results for: metaplasia. English. English. metaplasia. tissue alteration, state in which one type of tissue changes into ... metaplasia (British) package, bundle; group, gang; field, plot of land, yard, batch of commercial goods, bunch, make parcel of ... metaplasia. metaplastic. metaprotein. metapsychology. metasequoia. metasomatism; metasomatosis. metastable. metastasis. ...
Sponges are known to possess remarkable reconstitutive and regenerative abilities ranging from common wounding or body part regeneration to more impressive re-building of a functional body from dissociated cells. Among the four sponge classes, Homoscleromorpha is notably the only sponge group to possess morphologically distinct basement membrane and specialized cell-junctions, and is therefore considered to possess true epithelia. The consequence of this peculiar organization is the predominance of epithelial morphogenesis during ontogenesis of these sponges. In this work we reveal the underlying cellular mechanisms used during morphogenesis accompanying ectosome regeneration in the homoscleromorph sponge model: Oscarella lobularis. We identified three main sources of novel exopinacoderm during the processes of its regeneration and the restoration of functional peripheral parts of the aquiferous system in O. lobularis: (1) intact exopinacoderm surrounding the wound surface, (2) the endopinacoderm from
Hepatocyte Antigen Expression in Subtypes of Intestinal Metaplasia of the Stomach. Objective: Recently, hepatocyte antigen (Hep ... Read more about Hepatocyte Antigen Expression in Subtypes of Intestinal Metaplasia of the Stomach ... Read more about Hepatocyte Antigen Expression in Subtypes of Intestinal Metaplasia of the Stomach ... was introduced as a sensitive and reliable marker of intestinal metaplasia (IM). However, the distribution of Hep expression in ...
Cellular Plasticity: Reprogramming, Regeneration and Metaplasia (J3). joint with the meeting on Signal Dynamics and Signal ... Rates and Deadlines listed below are for the 2019-J3 "Cellular Plasticity: Reprogramming, Regeneration and Metaplasia" ...
Myelofibrosis with myeloid metaplasia (MMM) is currently classified as a classic (ie, BCR-ABL-negative) myeloproliferative ... Conventional and experimental drug therapy in myelofibrosis with myeloid metaplasia Curr Hematol Malig Rep. 2007 Feb;2(1):25-33 ... Myelofibrosis with myeloid metaplasia (MMM) is currently classified as a classic (ie, BCR-ABL-negative) myeloproliferative ...
Acetic Acid Chromoendoscopy to Judge Gastric Intestinal Metaplasia (IM). The safety and scientific validity of this study is ... The presence and the extent of gastric intestinal metaplasia(IM) is a good indicator of high risk group of gastric cancer. Many ... Metaplasia. Gastrointestinal Neoplasms. Digestive System Neoplasms. Neoplasms by Site. Neoplasms. Digestive System Diseases. ... Endoscopist judges the presence and the extent of gastric intestinal metaplasia during acetic acid chromoendoscopy. Endoscopist ...
agnogenic myeloid metaplasia listen (ag-noh-JEH-nik MY-eh-loyd meh-tuh-PLAY-zhuh) A progressive, chronic disease in which the ... Also called chronic idiopathic myelofibrosis, idiopathic myelofibrosis, myelosclerosis with myeloid metaplasia, and primary ...
Osseous Metaplasia in a Juvenile Rectal Polyp. Haynes, Harry R.*; Wiskin, Anthony E.†; Basude, Dharam†; Gradhand, Elise‡ ...
Genetic pathways involved in the progression of Barretts metaplasia to adenocarcinoma Br J Surg. 2002 Jul;89(7):824-37. doi: ... Background: The prediction of which patients with Barretts metaplasia will develop cancer is difficult. Better genetic ...
What is apocrine metaplasia? Meaning of apocrine metaplasia medical term. What does apocrine metaplasia mean? ... Looking for online definition of apocrine metaplasia in the Medical Dictionary? apocrine metaplasia explanation free. ... fibroadenoma with squamous metaplasia is a rare entity.. Squamous metaplasia with multiple epidermal cysts in fibroadenoma: a ... apocrine metaplasia. ap·o·crine met·a·pla·si·a. alteration of acinar epithelium of breast tissue to resemble apocrine sweat ...
Straightforward, unambiguous terminology can reduce the risk of labelling patients inappropriately. Whenever the definition of a diagnostic term is changed, a Pandoras box of potential confusion is opened. Are all clinicians and research investigators using the same criteria? If a patient has been given a diagnostic label, does it refer to the old or the new definition? Barretts oesophagus has changed its definition more than once over the past five decades and is a prime example of how changing definitions causes confusion for clinicians and investigators alike.1,2 A solution to this problem lies in avoiding the potentially confusing term "Barretts oesophagus" altogether. Moreover, this is possible by using existing terminology without the need for any new definitions.. ...
Agnogenic myeloid metaplasia, Authors: Jean-Loup Huret. Published in: Atlas Genet Cytogenet Oncol Haematol. ... Myelofibrosis with Myeloid Metaplasia (MMM). Idiopathic myelofibrosis. Agnogenic myeloid metaplasia. Written. 1997-08. Jean- ... Myelofibrosis with Myeloid Metaplasia (MMM); Idiopathic myelofibrosis; Agnogenic myeloid metaplasia;. Atlas Genet Cytogenet ... Cavazzini, F ; Cuneo, A. Myelofibrosis with myeloid metaplasia (MMM) - Idiopathic myelofibrosis - Agnogenic myeloid metaplasia ...
Metaplasia or transdifferentiation in striated muscle of Podocoryne carnea M. Sars ,Coelenterata, Hydrozoa,. [Andreas Brunnert] ... Metaplasia or transdifferentiation in striated muscle of Podocoryne carnea M. Sars ,Coelenterata, Hydrozoa,. Author:. Andreas ... schema:name "Metaplasia or transdifferentiation in striated muscle of Podocoryne carnea M. Sars " ;. schema:productID "45922134 ... Metaplasia or transdifferentiation in striated muscle of Podocoryne carnea M. Sars ,Coelenterata, Hydrozoa,/Andreas Brunnert; ...
  • Lenalidomide therapy in myelofibrosis with myeloid metaplasia. (nih.gov)
  • We present results of 2 similarly designed but separate phase 2 studies involving single-agent lenalidomide (CC-5013, Revlimid) in a total of 68 patients with symptomatic myelofibrosis with myeloid metaplasia (MMM). (nih.gov)
  • JAK2(V617F) and leukemic transformation in myelofibrosis with myeloid metaplasia. (nih.gov)
  • Amongst 42 consecutive patients with leukemic transformation (LT) from myelofibrosis with myeloid metaplasia (MMM) 72% carried the JAK2(V617F) mutation. (nih.gov)
  • What does the presence of myeloid metaplasia suggest in the workup of anemia? (medscape.com)
  • The diagnosis of myelofibrosis or neoplastic involvement of bone marrow is often suggested by evidence of myeloid metaplasia in the peripheral smear (ie, erythroid and granulocyte precursors). (medscape.com)
  • Myeloid metaplasia does not occur in aplastic disease. (medscape.com)
  • Myelofibrosis with myeloid metaplasia (MMM) is currently classified as a classic (ie, BCR-ABL-negative) myeloproliferative disorder characterized by anemia, multiorgan extramedullary hematopoiesis, constitutional symptoms, and premature death from either leukemic transformation or other disease complications. (nih.gov)
  • Also called chronic idiopathic myelofibrosis, idiopathic myelofibrosis, myelosclerosis with myeloid metaplasia, and primary myelofibrosis. (cancer.gov)
  • Causes of death include infection, leukemic transformation, bleeding, hepatic failure with portal hypertension due to myeloid metaplasia, heart failure. (atlasgeneticsoncology.org)
  • Agnogenic myeloid metaplasia (AMM) is a myeloproliferative disorder characterized by leukoerythroblastosis, tear-drop erythrocytes, extramedullary hematopoiesis with hepatosplenomegaly, and varying degrees of myelofibrosis. (koreamed.org)
  • The splenomegaly associated with myelofibrosis and agnogenic myeloid metaplasia should not be considered a manifestation of the fundamental proliferative process, nor should it be considered as necessarily compensatory for reduced marrow haematopoiesis. (bmj.com)
  • Consideration of two cases studied by the authors indicates that marked clinical improvement may be associated with splenectomy in selected cases of agnogenic myeloid metaplasia. (bmj.com)
  • In this trial, the question is addressed if zoledronic acid (Zometa, Novartis Pharma)could be of clinical benefit for patients with myelofibrosis and myeloid metaplasia (MMM). (clinicaltrials.gov)
  • male or female and at least 18 years-of-age histologically confirmed diagnosis of myelofibrosis with myeloid metaplasia (MMM). (clinicaltrials.gov)
  • This includes patients with agnogenic myeloid metaplasia (also known as idiopathic myelofibrosis) and patients with a preceding history of polycythemia vera or essential thrombocytemia (also known as post-polycytemic myelofibrosis). (clinicaltrials.gov)
  • Agnogenic myeloid metaplasia - also known as myelofibrosis (MF), chronic idiopathic myelofibrosis, idiopathic myeloid metaplasia, or MMM (myelofibrosis with myeloid metaplasia) - is the spontaneous scarring (or "fibrosis") of the bone marrow that disrupts the normal production of blood cells . (naturalpedia.com)
  • Agnogenic myeloid metaplasia often begins slowly and a patient's condition deteriorates over time. (naturalpedia.com)
  • Indicators for agnogenic myeloid metaplasia include abdominal pain and fullness, fatigue, and susceptibility to infection. (naturalpedia.com)
  • Treatment options for agnogenic myeloid metaplasia include bone marrow transplant, chronic blood infusions, and iron chelation therapy. (naturalpedia.com)
  • Idiopathic generalized myelofibrosis with myeloid metaplasia is a disease of unknown etiology in which the clinical and morphologic manifestations vary greatly even during the course of an individual case. (annals.org)
  • Myeloid metaplasia is a constant and persistent finding, even when the bone marrow is hypercellular. (annals.org)
  • Standard myeloablative conditioning prior to allogeneic hematopoietic stem cell (HSC) transplantation has been associated with significant toxicity in patients older than 45 years of age with myelofibrosis with myeloid metaplasia (MMM). (bloodjournal.org)
  • Myelofibrosis with myeloid metaplasia (MMM) is a clonal hematopoietic disorder characterized by bone marrow fibrosis, a leukoerythroblastic blood picture, splenomegaly, and extramedullary hematopoiesis. (bloodjournal.org)
  • Agnogenic myeloid metaplasia (AMM) is a chronic myeloproliferative disorder in which patients with poor prognostic features, receiving conventional treatments, have a median survival of less than 3 years. (bloodjournal.org)
  • A GNOGENIC MYELOID metaplasia (AMM) is a clonal hematopoietic stem cell disorder characterized by bone marrow fibrosis, extramedullary hematopoiesis, splenomegaly, and a leukoerythroblastic blood picture. (bloodjournal.org)
  • Determine the efficacy of allogeneic bone marrow transplantation (BMT) following high-dose cyclophosphamide and total body irradiation in patients with multiple myeloma, agnogenic myeloid metaplasia, or chronic myelogenous leukemia in first or second chronic phase. (knowcancer.com)
  • Agnogenic myeloid metaplasia (medical condition): The bone marrow is consists of tissues which make blood cells and fibrous. (rightdiagnosis.com)
  • Agnogenic myeloid metaplasia is listed as a " rare disease " by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH). (rightdiagnosis.com)
  • This means that Agnogenic myeloid metaplasia, or a subtype of Agnogenic myeloid metaplasia, affects less than 200,000 people in the US population. (rightdiagnosis.com)
  • myeloid metaplasia occurring as the primary condition, often in association with myelofibrosis. (thefreedictionary.com)
  • See myeloid metaplasia . (thefreedictionary.com)
  • Metaplasia is not synonymous with dysplasia , and is not considered to be an actual cancer. (wikipedia.org)
  • The medical significance of metaplasia is that in some sites where pathological irritation is present, cells may progress from metaplasia, to develop dysplasia, and then malignant neoplasia (cancer). (wikipedia.org)
  • My lab results from an endoscopy state positive for intestinal metaplasia(IM), negative for dysplasia. (healingwell.com)
  • Often in pathological tests, a condition of Dysplasia where the growth and differentiation of cells are delayed are compared with Metaplasia where a mature cell of a distinct kind is replaced by another mature cell of yet another distinguished type. (differencebetween.net)
  • Experimental group consisted of 48 patients with Barrett's adenocarcinoma and age-matched control group consisted of 44 patients with reflux esophagitis or Barrett's metaplasia without dysplasia. (aacrjournals.org)
  • This paper to describe a case of dysontogenic urethral metaplasia in a one month old mongrel feline who also had bilateral renal dysplasia. (uel.br)
  • Dysontogenic metaplasia in cats are scarce and this change may be associated with renal dysplasia and/or lower urinary tract. (uel.br)
  • Dysontogenic metaplasia in urinary tract feline with renal dysplasia, has not been described. (uel.br)
  • Metaplasia is not synonymous with dysplasia and is not considered as directly carcinogenetic. (humpath.com)
  • This technique leaves a significant proportion of mucosa unsampled, decreasing the likelihood of detecting residual or recurrent intestinal metaplasia (IM) and ED. Wide Area Transepithelial Sampling with Computer-Assisted 3-Dimensional Tissue Analysis (WATS3D) has been shown to improve detection of both metaplasia and dysplasia when added to FB in screening/surveillance of BE. (sages.org)
  • Within the cross-sectional group, 15% of patients (n = 17) had intestinal metaplasia or dysplasia in the cardia after CEIM. (mdedge.com)
  • Of those 17 patients, 12 had intestinal metaplasia, 2 were indefinite for dysplasia, and 3 had low-grade dysplasia. (mdedge.com)
  • Within the longitudinal group, 28% of patients (n = 12) had intestinal metaplasia or dysplasia in the cardia before ablation. (mdedge.com)
  • at 18 months post CEIM, two patients had intestinal metaplasia and none had dysplasia. (mdedge.com)
  • Late Recurrence of Barrett's Esophagus After Complete Eradication of Intestinal Metaplasia is Rare: Final Report From Ablation in Intestinal Metaplasia Containing Dysplasia Trial. (snfge.org)
  • The goal of treatment for Barrett's esophagus (BE) with dysplasia is complete eradication of intestinal metaplasia (CEIM). (snfge.org)
  • We report results from a 5-year follow-up analysis of patients with BE and dysplasia treated by radiofrequency ablation (RFA) in the randomized controlled Ablation of Intestinal Metaplasia Containing Dysplasia (AIM) trial. (snfge.org)
  • Gastric intestinal metaplasia is a precancerous change of the mucosa of the stomach with intestinal epithelium, and is associated with an increased risk of dysplasia and cancer. (readbyqxmd.com)
  • Newer methods of mucosal ablation, such as the radiofrequency balloon, have been developed for the treatment of patients with Barrett's metaplasia or dysplasia. (elsevier.com)
  • These newly developed techniques are able to treat large fields of glandular epithelium in a short treatment procedure using safe, effective, durable methods for the complete ablation of Barrett's metaplasia and low-grade dysplasia. (elsevier.com)
  • Wolfsen, HC 2005, ' Endoprevention of esophageal cancer: Endoscopic ablation of Barrett's metaplasia and dysplasia ', Expert Review of Medical Devices , vol. 2, no. 6, pp. 713-723. (elsevier.com)
  • Gastric metaplasia and Helicobacter pylori infection. (bmj.com)
  • Effect of Helicobacter pylori eradication on gastric metaplasia of the duodenum. (bmj.com)
  • Helicobacter pylori (H. pylori) is a major factor in determining the risk for development of gastric adenocarcinoma through the intermediate steps of atrophic gastritis and intestinal metaplasia. (unboundmedicine.com)
  • TY - JOUR T1 - Atrophic gastritis and intestinal metaplasia in Helicobacter pylori infection: the role of CagA status. (unboundmedicine.com)
  • In this sense, a prospective and descriptive study was conducted in the Institute of Gastroenterology in patients presenting with duodenogastric and high total bile acids to know the association between the intestinal metaplasia and the presence or not of Helicobacter pylori . (sld.cu)
  • In patients with duodenogastric reflux, presence of Helicobacter pylori don't seems to be associated with intense degrees of intestinal metaplasia, although the microorganism is present in all categories, but when there is not Helicobacter pylori , intestinal metaplasia to tend to develop in its less severe degrees. (sld.cu)
  • Because gastric metaplasia to the SPEM lineage is considered as a preneoplastic lesion of gastric cancer, it is possible that inhibition of TNF-α-dependent inflammation, together with eradication of Helicobacter , can be an effective prevention strategy for gastric cancer. (aacrjournals.org)
  • Gastric hyperplasia and mucous cell metaplasia with Brunner's gland-like morphology in the K19-C2mE mice is similar to that found in the Helicobacter -infected mice ( 3 , 6 ). (aacrjournals.org)
  • Background: To determine the relation of Helicobacter pylori infection with chronic inflammation, atrophy, activity level and intestinal metaplasia. (ajol.info)
  • A statistically significant relationship was found between Helicobacter pylori colonization intensity and the degrees of neutrophil activity, chronic inflammation and intestinal metaplasia. (ajol.info)
  • Conclusion: We concluded that Helicobacter pylori infection results in neutrophil activation and chronic gastritis, and that it has a role in the development of intestinal metaplasia. (ajol.info)
  • The greater the intensity of Helicobacter pylori infection, the greater the degrees of neutrophil activation, chronic gastritis and intestinal metaplasia. (ajol.info)
  • Multiple risk factors have been associated with the development of gastric intestinal metaplasia interplay, including Helicobacter pylori infection and associated genomics, host genetic factors, environmental milieu, rheumatologic disorders, diet, and intestinal microbiota. (readbyqxmd.com)
  • Chronic atrophic gastritis and intestinal metaplasia related to Helicobacter pylori infection, are major risk factors for gastric adenocarcinoma. (readbyqxmd.com)
  • Intracellular and interstitial expression of Helicobacter pylori virulence genes in gastric precancerous intestinal metaplasia and adenocarcinoma. (semanticscholar.org)
  • Gastric intestinal metaplasia (IM) and gastric cancer are associated with Helicobacter pylori, but the bacterium often is undetectable in these lesions. (semanticscholar.org)
  • Abstract - Tendons that wrap around bones often undergo fibrocartilaginous metaplasia. (va.gov)
  • I cam across this abstract on Paneth Cell Metaplasia . (crohnsforum.com)
  • Because infection by H. pylori strains possessing cagA (cytotoxin-associated gene A), a gene encoding a high-molecular-weight immunodominant antigen (CagA), is associated with enhanced induction of gastritis, the aim of our study was to evaluate potential differences in the prevalence and intensity of atrophy and intestinal metaplasia between CagA-positive and CagA-negative H. pylori-infected patients. (unboundmedicine.com)
  • Infection with CagA-positive H. pylori strains is associated with an increased prevalence and intensity of antral atrophy and intestinal metaplasia, in addition to higher degrees of gastritis. (unboundmedicine.com)
  • The positive associations with atrophy and intestinal metaplasia have implications for models of gastric carcinogenesis. (bmj.com)
  • The specimens were histologically evaluated for H. pylori, inflammatory activity, chronic inflammation, gastric atrophy and intestinal metaplasia. (ajol.info)
  • Autoimmune gastritis present a risk of cancer related to atrophy and intestinal metaplasia. (readbyqxmd.com)
  • Atrophy and intestinal metaplasia are early phenotypic markers in gastric carcinogenesis. (readbyqxmd.com)
  • Intestinal metaplasia Squamous metaplasia Micrograph of Barrett's esophagus, an example of glandular metaplasia. (wikipedia.org)
  • The prediction of which patients with Barrett's metaplasia will develop cancer is difficult. (nih.gov)
  • BACKGROUND AND AIMS: Cytokeratin (CK) 7 and 20 patterns are specific for long and short segments of Barrett's oesophagus but their use has not been assessed in intestinal metaplasia arising in macroscopically normal gastro-oesophageal junction (GOJ). (biomedsearch.com)
  • CONCLUSION: In patients presenting with intestinal metaplasia in normal appearing GOJ, the cytokeratin pattern identifies two groups of patients, one with features identical to those of long segment Barrett's oesophagus and one with features seen in H pylori gastritis. (biomedsearch.com)
  • Background: Barrett's metaplasia is an acquired condition caused by protracted gastroesophageal reflux and involves replacement of normal squamous with the columnar, intestinal type epithelium. (aacrjournals.org)
  • Patients diagnosed with Barrett's metaplasia have a 30- to 40-fold increased risk of developing adenocarcinoma compared with the general population. (aacrjournals.org)
  • 2001). The effect of this polymorphism has not been evaluated in patients with esophageal adenocarcinoma arising in Barrett's metaplasia. (aacrjournals.org)
  • The objective of this study was to evaluate Ki-67 antigen expression in patients with Barrett's esophagus and esophageal adenocarcinoma and to assess its correlation with the metaplasia-esophageal adenocarcinoma progression. (ufrgs.br)
  • Using immunohistochemistry we evaluated the Ki-67 index in patients with Barrett's esophagus, esophageal adenocarcinoma, and controls.We included patients with endoscopically visible columnar mucosa of the distal esophagus (whose biopsies revealed specialized intestinal-type metaplasia), patients with esophageal and esophagogastric tumors types I and II, and patients with histologically normal gastric mucosa (control). (ufrgs.br)
  • The pathological basis of the mucous hypersecretion is mucous cell metaplasia, abnormal transformation of the normal respiratory tract mucosa into a thickened mucosa with a high density of the goblet cell population in response to microorganic infections or asthma. (hindawi.com)
  • However, under pathological conditions inducing mucous cell metaplasia, an increased goblet cell population in the mucosa produces excessive mucins, while the loss of ciliated cells in the mucosa results in the dysfunction of the mucociliary transport system, leading to subsequent problems such as fluid accumulation and repeated infections. (hindawi.com)
  • Bile reflux and intestinal metaplasia in gastric mucosa. (bmj.com)
  • Mucinous metaplasia of the squamous mucosa in Zoon's balanitis is exceedingly rare - only seven cases occurring in elder men have been reported in the English literature [1-4], and the pathogenic association between the two processes is unknown. (scirp.org)
  • Gastric Metaplasia in Duodenal Mucosa - Key Factor for H. pylori Colonization and Duodenal Ulcer Pathogenesis? (springer.com)
  • In conclusion, a single dose of 2,6-(diCl-MeSO 2 -B) results in persistent metaplasia and remodeling of the olfactory mucosa, and a long-lasting but transient induction of GFAP in the olfactory bulb. (diva-portal.org)
  • White light endoscopy does not allow direct biopsy of intestinal metaplasia due to a lack of contrast of the mucosa. (readbyqxmd.com)
  • One example of pathological irritation is cigarette smoke, which causes the mucus-secreting ciliated pseudostratified columnar respiratory epithelial cells that line the airways to be replaced by stratified squamous epithelium, or a stone in the bile duct that causes the replacement of the secretory columnar epithelium with stratified squamous epithelium ( squamous metaplasia ). (wikipedia.org)
  • Metaplasia is an adaptation that replaces one type of epithelium with another that is more likely to be able to withstand the stresses it is faced with. (wikipedia.org)
  • Squamous metaplasia of the airway epithelium is characterized by replacement of bronchiolar or bronchial epithelium with squamous epithelium. (nih.gov)
  • Squamous metaplasia can be seen as a response to chronic irritation or injury and is thought to be an adaptive change, as the squamous epithelium is more resistant to injury than is respiratory or alveolar epithelium. (nih.gov)
  • A deficiency of vitamin A (retinoic acid) induces squamous metaplasia in the respiratory epithelium, and vitamin A excess suppresses keratinization . (humpath.com)
  • Metaplasia from squamous to columnar type may also occur, as in Barrett esophagus, in which the esophageal squamous epithelium is replaced by intestinal-like columnar cells under the influence of refluxed gastric acid. (humpath.com)
  • However, the factors that predispose to metaplasia, if persistent, may induce malignant transformation in metaplastic epithelium. (humpath.com)
  • Thus, the common form of cancer in the respiratory tract is composed of squamous cells, which arise in areas of metaplasia of the normal columnar epithelium into squamous epithelium. (humpath.com)
  • Mucinous metaplasia of the squamous epithelium of the glans penis is very rarely seen in the setting of Zoon's balanitis. (scirp.org)
  • Squamous metaplasia of the bronchial epithelium is often associated with a history of cigarette smoking and the development of squamous cell carcinoma. (medscimonit.com)
  • Further histopathological examination of the anterior lens capsule demonstrated replacement of the capsule by a thick layer of fibrous tissue with histological evidence of metaplasia of anterior lens epithelium. (arvojournals.org)
  • Reduced aqueous tear production is known to promote squamous metaplasia with goblet cell (GC) loss in the conjunctival epithelium. (arvojournals.org)
  • A key issue in otitis media is mucous cell metaplasia which is responsible for mucous hypersecretion and persistence of the disease. (hindawi.com)
  • However, little is known about the molecular mechanisms of mucous cell metaplasia in otitis media. (hindawi.com)
  • On the other hand, SAM-pointed domain-containing Ets transcription factor (SPDEF), a member of the "Ets" transcription factor family, has been reported to trigger the mucous cell metaplasia of pulmonary infectious diseases or athsma. (hindawi.com)
  • Atoh1 and SPDEF could be the therapeutic targets for otitis media associated with mucous cell metaplasia which is frequently considered "intractable" in the clinical settings. (hindawi.com)
  • I had an upper endoscopy and the pathology report shows I have focal intestinal metaplasia. (dailystrength.org)
  • I did some research and found a paper published in the Amer. Jnl of Gastroenterology- on the www.ncbi.nlm.nih.gov/pmc/articles website--It's called "Pathology of Gastric Intestinal Metaplasia-Clinical Implications. (dailystrength.org)
  • In the first stage of intestinal metaplasia, the patient's damaged esophageal lining begins to grow the type of cells that line the intestinal wall rather than the normal squamous cells of the esophagus, explains Johns Hopkins Pathology. (reference.com)
  • Doctors believe the process of intestinal metaplasia begins in response to gastroesophageal reflux, states Johns Hopkins Pathology. (reference.com)
  • Among 1566 prostate specimens referred to 2 pathology centers of Tehran, we studied on cases with a diagnosis of metaplasia, during a 2-year period. (eurekamag.com)
  • We present the case of a dedifferentiated paratesticular liposarcoma with osseous metaplasia of the spermatic cord, in a male presented with acute scrotum. (hindawi.com)
  • Kidney - Metaplasia, Osseous in a female B6C3F1 mouse from a chronic study. (nih.gov)
  • Osseous metaplasia is characterized by mature-appearing bone in the renal parenchyma. (nih.gov)
  • Osseous metaplasia needs to be distinguished from mineralization. (nih.gov)
  • Osseous metaplasia should be recorded but need not be graded. (nih.gov)
  • In addition, the frequency of osseous metaplasia and/or chondromatous metaplasia increased with age at time of excision of bicuspid aortic valves, while tricuspid aortic valves showed the same incidence regardless of patient age. (harvard.edu)
  • No osseous or chondromatous metaplasia was observed within the cusps of any of the prosthetic tissue valves.Conclusions: Osseous and chondromatous metaplasia are common findings in native aortic valves but do not occur in prosthetic tissue aortic valves. (harvard.edu)
  • Bicuspid valves appear to have an inherent proclivity for metaplasia, as demonstrated by their higher rates of osseous metaplasia and/or chondromatous metaplasia both overall and at earlier age compared to tricuspid and prosthetic tissue aortic valves. (harvard.edu)
  • Though not typically considered preneoplastic, under some conditions squamous metaplasia may give rise to neoplasia (cystic keratinizing epithelioma or squamous cell carcinoma). (nih.gov)
  • There have been reports of keratinising squamous metaplasia progressing to squamous cell carcinoma or having concurrent squamous cell carcinoma. (bmj.com)
  • Evaluating bronchial brushings, we concluded that squamous metaplasia accompanied pathological processes other than squamous cell carcinoma. (medscimonit.com)
  • The finding of squamous metaplasia in bronchial brushings might suggest the presence of a proliferative process other than squamous cell carcinoma, especially small cell carcinoma and be an indication for further diagnostics. (medscimonit.com)
  • Micrograph of a gastro - esophageal junction with pancreatic acinar metaplasia . (wikipedia.org)
  • Lesions were classified as fibrocystic change with or without epithelial hyperplasia if the lesion had apocrine metaplasia , nodular adenosis, sclerosing adenosis, papillomatosis, and usual ductal hyperplasia. (thefreedictionary.com)
  • Complex fibroadenoma refers to fibroadenomas with foci of cysts, sclerosing adenosis, epithelial calcifications, and papillary apocrine metaplasia , and has a higher future risk of malignancy. (thefreedictionary.com)
  • A striking aspect of c-erbB2 staining was that 7 of the 10 IDH lesions containing apocrine metaplasia or hyperplasia showed focal, weak staining. (thefreedictionary.com)
  • Papillary apocrine metaplasia is a common papillary lesion that is associated with breast cysts. (thefreedictionary.com)
  • Epitheliosis, apocrine metaplasia , pseudo angiomatous stromal hyperplasia, atrophy and cystically dilated ducts were among the major microscopic features observed. (thefreedictionary.com)
  • Juvenile papillomatosis is characterized by the presence of multiple dilated ducts and cysts, extensive UDH, extensive apocrine metaplasia , apocrine papillary hyperplasia, and intraductal and intracystic papillomas (Figure 1, a and b). (thefreedictionary.com)
  • 1 Similarly fibroadenoma with apocrine metaplasia and multinucleated stromal giant cells occur rarely in the age group found in our series. (thefreedictionary.com)
  • Focal apocrine metaplasia is frequently seen within intraductal papillomas but is almost always absent in intraductal papillary carcinomas, making it a useful adjunct in the differential diagnosis along with other features (Figure 3, A and B). (thefreedictionary.com)
  • The immunoprofiles of this oncocytic metaplasia such as p53 negativity and positivity for androgen receptor and GCDFP-15 demonstrates similarity to apocrine metaplasia in the breast. (ovid.com)
  • The prevalence of intestinal metaplasia was greatest in patients with both H pylori infection and high bile acid concentrations. (bmj.com)
  • I was diagnosed with intestinal metaplasia with no Hpylori few weeks ago. (dailystrength.org)
  • The study also added that chronic H. pylori infections may develop over many years, progressing from gastritis to internal metaplasia, and even gastric cancer . (medicalnewstoday.com)
  • Two recent classifications OLGA (Operative Link on Gastritis Assessment) and OLGIM (Operative Link on Gastritic Intestinal Metaplasia assessment) have been proposed to reveal the high progressive risk forms (stages III and IV). (readbyqxmd.com)
  • Intestinal metaplasia of the urethra may be seen in many congenital, iatrogenic, and reactive conditions, as well as in association with malignant conditions such as urethral adenocarcinoma. (pubmedcentralcanada.ca)
  • A metaplasia tubária (MT) endocervical é uma lesão benigna, classificada como pseudoneoplásica, que tem sido confundida com o adenocarcinoma in situ. (scielo.br)
  • OBJECTIVE - Among uterine cervix tumorlike lesions, tubal metaplasia (TM) has been confused with endocervical in situ adenocarcinoma. (scielo.br)
  • I was diagnosed with goblet cell metaplasia one and -a half years ago. (dailystrength.org)
  • After long-term inhalation of Printex 90 and titanium dioxide, goblet cell metaplasias occured in the peripheral lung tissue of 11/1700 female SPF Wistar rats. (fraunhofer.de)
  • The majority of goblet cell metaplasias was seen at the bronchiolo-alveolar junction as round, mucus-filled nodules with a diameter of 1 - 20 mm. (fraunhofer.de)
  • Goblet cell metaplasias have been reported in pulmonary airways of man and hamsters, but have rarely been described in the peripheral lung tissue of rats. (fraunhofer.de)
  • In the stomach, chronic inflammation causes metaplasia and creates a favorable environment for the evolution of gastric cancer. (jci.org)
  • Removal of circulating glucocorticoids in mice by adrenalectomy resulted in the rapid onset of spontaneous gastric inflammation, oxyntic atrophy, and spasmolytic polypeptide-expressing metaplasia (SPEM), a putative precursor of gastric cancer. (jci.org)
  • Our results highlight the requirement for endogenous glucocorticoid signaling within the stomach to prevent spontaneous gastric inflammation and metaplasia, and suggest that glucocorticoid deficiency may lead to gastric cancer development. (jci.org)
  • Persistent pulmonary inflammation, airway mucous metaplasia and migration of multiwalled carbon nanotubes from the lung after subchronic exposure. (cdc.gov)
  • Metaplasia is reversible and usually occurs in response to chronic irritation and inflammation and allows for substitution of cells that are better able to survive under circumstances in which a more fragile cell type might succumb. (humpath.com)
  • It is possible that infection of bacteria, parasites or virus such as salmonellae caused inflammation of some cells of the peritoneum resulting in coelomic metaplasia. (worldwidehealth.com)
  • Among 705 evaluable cytology specimens, prevalence of inflammation (39%), hyperkeratosis (30%), metaplasia (33%), and frank atypia (0.4%) was notably higher than in previously studied, non-endemic populations. (ajtmh.org)
  • Importantly, spasmolytic polypeptide/trefoil factor 2-expressing metaplasia (SPEM) in the K19-C2mE stomach was also suppressed in the Tnf (−/−) K19-C2mE mice, indicating that TNF-α-dependent inflammation is responsible for SPEM development. (aacrjournals.org)
  • Inflammation was found in 95%, glandular atrophy in 38%, intestinal metaplasia in 28% of the cases. (ajol.info)
  • Chronic inflammation with mucous metaplasia and airway remodeling are hallmarks of allergic asthma, and these outcomes have been associated with enhanced expression and activation of EGFR signaling. (jci.org)
  • DUOX1 deficiency also attenuated several EGFR-dependent features of HDM-induced allergic airway inflammation, including neutrophilic inflammation, type 2 cytokine production (IL-33, IL-13), mucous metaplasia, subepithelial fibrosis, and central airway resistance. (jci.org)
  • The primary outcome was diagnostic ability of the two methods for patients with pre-neoplastic lesions such as intestinal metaplasia (IM) and mucosal atrophy. (springer.com)
  • Thus, the main purpose of this work is to localize and characterize tubal metaplasia and its relation to other morphological lesions in the cervix. (scielo.br)
  • In this study, the progression of precancerous lesions after H pylori treatment was evaluated.Patients with incomplete or complete intestinal metaplasia and/or gastric atrophy at the index endoscopy, were examined for the extension/histological worsening of precancerous lesions at the endoscopy surveillance for gastric cancer. (readbyqxmd.com)
  • In both the pyloric and the fundic gland mucosae, the average numbers of type C metaplasia (intestinal crypts with Paneth cells) and total numbers of metaplastic foci in rats of group 3 were much higher than those in group 4 (P less than 0.05). (biomedsearch.com)
  • All showed Paneth Cell Metaplasia. (crohnsforum.com)
  • Glandular metaplasia is a type of metaplasia where irritated tissue converts to a glandular form. (wikipedia.org)
  • Light micrograph of a section through bronchial (airway) tissue from the lungs showing metaplasia, the transformation of one cell type to another. (sciencephoto.com)
  • This is a case of a Nile monitor that suffered fibrous osteodystrophy and chondroid metaplasia after being fed mostly muscle tissue for over two years. (bva.co.uk)
  • The urethra was thickened, hard to cut, and histologically, was replacing the connective tissue, cartilage and endochondral ossification areas, which features dysontogenic metaplasia. (uel.br)
  • Connective tissue metaplasia is the formation of cartilage, bone, or adipose tissue (mesenchymal tissues) in tissues that normally do not contain these elements. (humpath.com)
  • An area of squamous metaplasia and an area of residual Skene's gland tissue both showed strong nuclear reactivity for p63. (pubmedcentralcanada.ca)
  • The two types of tissue both showed a reversal of hyperplasia and metaplasia when treated with retinoids (= vitamin A and analogs). (springer.com)
  • Carrick J, Lee A, Hazell S, Ralston M, Daskalopoulos G (1989) Campylobacter pylori, duodenal ulcer, and gastric metaplasia: possible role of functional heterotopic tissue in ulcerogenesis. (springer.com)
  • Metaplasia is frequently induced by chronic cellular injury and represents an adaptation in which a tissue replaces a sensitive cell type with one better able to resist the injury. (pathwaymedicine.org)
  • Airway epithelial changes included hypertrophy, cellular atypia and mucous metaplasia. (cdc.gov)
  • This type of metaplasia is less clearly seen as an adaptive response. (humpath.com)
  • The 7,12-dimethylbenzanthracene-induced skin papilloma of the mouse and the 3-methylcholanthrene-induced hyperplasia and metaplasia in prostate organ cultures were studied by electron microscopy. (springer.com)
  • An H. pylori infection may be a cause of intestinal metaplasia. (medicalnewstoday.com)
  • Some healthcare professionals believe an H. pylori infection causes intestinal metaplasia, but there is also a range of risk factors that may increase the risk of developing it. (medicalnewstoday.com)
  • One study in Gastroenterology Research and Practice noted that 38.6 percent of people with intestinal metaplasia also had an H. pylori infection. (medicalnewstoday.com)
  • Squamous metaplasia is simply the replacement of one normal squamous cell with another by pathological definition. (healthtap.com)
  • Although by definition metaplasia is a reversible adaptation, it frequently precedes and may represent the initial steps of malignant transformation. (pathwaymedicine.org)
  • Predisposition to urinary tract epithelial metaplasia in Schistosoma haematobium infection. (ajtmh.org)
  • Histopathological examination revealed keratinising squamous metaplasia of the urinary bladder ( figure 3 ). (bmj.com)
  • Keratinising squamous metaplasia of the urinary bladder is a rare condition that occurs due to chronic irritation of urinary bladder usually by bacteria, and predisposing conditions include neurogenic bladder, chronic catheterisation, vitamin A deficiency, urinary fistulas and bladder outlet obstruction. (bmj.com)
  • Mucinous metaplasia was confirmed by PAS and Mucin stains, and plasmacytosis was confirmed by immunohistochemistry for CD138 and MUM1 markers. (scirp.org)
  • The etiology of zoon's balanitis as well as the significance of mucinous metaplasia in these setting are unclear and need to be further investigated. (scirp.org)
  • 7) Some authors make a distinction between a primary form, which represents an active cartilaginous metaplasia , and a secondary form that is characterized by less cellular atypia, which is a passive process that involves intra-articular loss of fragments secondary to trauma, arthropathies, or arthritis. (thefreedictionary.com)
  • The principal clinical differential diagnosis are extraskeletal mesenchimal chondrosarcoma, giant cell tumor of the tendon sheath with foci of cartilaginous metaplasia , calcifying aponeurotic fibroma, synovial chondromatosis, and nodular chondrometaplasia. (thefreedictionary.com)
  • The most common epithelial metaplasia is columnar to squamous (squamous metaplasia), as occurs in the respiratory tract in response to chronic irritation. (humpath.com)
  • The authors' case demonstrates the benign nature of oncocytic metaplasia and supports the common origin of oncocytic cells and columnar cells in hidradenoma papilliferum. (ovid.com)
  • A total of 56 (56%) patients belonged to blood group A. Among them, six (10.7%) patients who did not express antigen in squamous metaplasia, showed carcinoma at the moment of the biopsy (n = 3) or developed synchronous lung carcinoma (n = 3). (ersjournals.com)
  • In the follow-up, synchronous carcinoma was defined as a carcinoma diagnosed within 1 yr after a biopsy, demonstrating squamous metaplasia. (ersjournals.com)
  • Wyatt JI, Rathbone BJ, Dixon MF, Heatley RV (1987) Campylobacter pyloridis and acid induced gastric metaplasia in the pathogenesis of duodenitis. (springer.com)
  • To investigate the role of interferon (IFN)-γ in the pathogenesis of conjunctival squamous metaplasia in dry eye. (arvojournals.org)
  • These findings suggest that IFN-γ plays a pivotal role in promoting conjunctival squamous metaplasia in dry eye, and they provide insight into the immune pathogenesis of keratoconjunctivitis sicca. (arvojournals.org)
  • Lung, Alveolus - Metaplasia, Squamous in a female Harlan Sprague-Dawley rat from a subchronic study. (nih.gov)
  • Lung, Alveolus - Metaplasia, Squamous in a female Harlan Sprague-Dawley rat from a chronic study. (nih.gov)
  • Lung, Bronchiole - Metaplasia, Squamous in a male F344/N rat from an acute study. (nih.gov)
  • Lung, Bronchus - Metaplasia, Squamous in a male F344/N rat from a subchronic study. (nih.gov)
  • Lung, Bronchiole - Metaplasia, Squamous, Atypical from a male B6C3F1 mouse in a subchronic study. (nih.gov)
  • Lung - Metaplasia, Squamous should be diagnosed whenever present and assigned a severity grade. (nih.gov)
  • Lung metaplasia. (sciencephoto.com)
  • The aim of the present study was to evaluate the expression of blood group antigens in squamous bronchial metaplasia in order to determine whether this factor could identify patients at risk of lung cancer. (ersjournals.com)
  • Keratinizing desquamative squamous metaplasia (KDSM) in the renal pelvis is a rare condition with unclear malignant potential. (canjurol.com)
  • During the period 1995-1996, we performed 212 bronchial brushings, finding 69 cases of metaplasia. (medscimonit.com)