AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceHealth Care
MetabolomeMetabolomicsGas Chromatography-Mass SpectrometryMass SpectrometryMetabolismPrincipal Component AnalysisChromatography, LiquidAdrenogenital SyndromeMetabolic Networks and PathwaysSteroid Metabolism, Inborn ErrorsSecondary MetabolismVolatile Organic CompoundsElectrophoresis, CapillaryProteomeMagnetic Resonance SpectroscopySystems BiologyCarbonEricaceaeModels, BiologicalTranscriptomeGene Expression ProfilingGlycolysisGene Expression Regulation, PlantMetagenomeSpectrometry, Mass, Electrospray IonizationArabidopsisBiosynthetic PathwaysPentose Phosphate PathwaySolid Phase MicroextractionTandem Mass SpectrometryDatabases, FactualAmino AcidsPlant LeavesLeast-Squares Analysis
Metabolome
The dynamic collection of metabolites which represent a cell's or organism's net metabolic response to current conditions.
Metabolomics
The systematic identification and quantitation of all the metabolic products of a cell, tissue, organ, or organism under varying conditions. The METABOLOME of a cell or organism is a dynamic collection of metabolites which represent its net response to current conditions.
Gas Chromatography-Mass Spectrometry
A microanalytical technique combining mass spectrometry and gas chromatography for the qualitative as well as quantitative determinations of compounds.
Mass Spectrometry
An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.
Metabolism
The chemical reactions that occur within the cells, tissues, or an organism. These processes include both the biosynthesis (ANABOLISM) and the breakdown (CATABOLISM) of organic materials utilized by the living organism.
Principal Component Analysis
Mathematical procedure that transforms a number of possibly correlated variables into a smaller number of uncorrelated variables called principal components.
Chromatography, Liquid
Chromatographic techniques in which the mobile phase is a liquid.
Adrenogenital Syndrome
Abnormal SEX DIFFERENTIATION or congenital DISORDERS OF SEX DEVELOPMENT caused by abnormal levels of steroid hormones expressed by the GONADS or the ADRENAL GLANDS, such as in CONGENITAL ADRENAL HYPERPLASIA and ADRENAL CORTEX NEOPLASMS. Due to abnormal steroid biosynthesis, clinical features include VIRILISM in females; FEMINIZATION in males; or precocious sexual development in children.
Metabolic Networks and Pathways
Complex sets of enzymatic reactions connected to each other via their product and substrate metabolites.
Steroid Metabolism, Inborn Errors
Errors in metabolic processing of STEROIDS resulting from inborn genetic mutations that are inherited or acquired in utero.
Secondary Metabolism
A physiochemical process which occurs in a wide range of organisms which unlike BASAL METABOLISM is not required for or essential to short-term survivability but to long-term general well-being of the organism.
Volatile Organic Compounds
Organic compounds that have a relatively high VAPOR PRESSURE at room temperature.
Electrophoresis, Capillary
A highly-sensitive (in the picomolar range, which is 10,000-fold more sensitive than conventional electrophoresis) and efficient technique that allows separation of PROTEINS; NUCLEIC ACIDS; and CARBOHYDRATES. (Segen, Dictionary of Modern Medicine, 1992)
Proteome
The protein complement of an organism coded for by its genome.
Magnetic Resonance Spectroscopy
Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).
Systems Biology
Comprehensive, methodical analysis of complex biological systems by monitoring responses to perturbations of biological processes. Large scale, computerized collection and analysis of the data are used to develop and test models of biological systems.
Carbon
A nonmetallic element with atomic symbol C, atomic number 6, and atomic weight [12.0096; 12.0116]. It may occur as several different allotropes including DIAMOND; CHARCOAL; and GRAPHITE; and as SOOT from incompletely burned fuel.
Ericaceae
The heath plant family of the order Ericales, subclass Dilleniidae, class Magnoliopsida that are generally shrubs or small trees. Leaves are alternate, simple, and leathery; flowers are symmetrical with a 4- or 5-parted corolla of partly fused petals.
Models, Biological
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
Transcriptome
The pattern of GENE EXPRESSION at the level of genetic transcription in a specific organism or under specific circumstances in specific cells.
Gene Expression Profiling
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
Glycolysis
A metabolic process that converts GLUCOSE into two molecules of PYRUVIC ACID through a series of enzymatic reactions. Energy generated by this process is conserved in two molecules of ATP. Glycolysis is the universal catabolic pathway for glucose, free glucose, or glucose derived from complex CARBOHYDRATES, such as GLYCOGEN and STARCH.
Gene Expression Regulation, Plant
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in plants.
Metagenome
A collective genome representative of the many organisms, primarily microorganisms, existing in a community.
Spectrometry, Mass, Electrospray Ionization
A mass spectrometry technique used for analysis of nonvolatile compounds such as proteins and macromolecules. The technique involves preparing electrically charged droplets from analyte molecules dissolved in solvent. The electrically charged droplets enter a vacuum chamber where the solvent is evaporated. Evaporation of solvent reduces the droplet size, thereby increasing the coulombic repulsion within the droplet. As the charged droplets get smaller, the excess charge within them causes them to disintegrate and release analyte molecules. The volatilized analyte molecules are then analyzed by mass spectrometry.
Arabidopsis
A plant genus of the family BRASSICACEAE that contains ARABIDOPSIS PROTEINS and MADS DOMAIN PROTEINS. The species A. thaliana is used for experiments in classical plant genetics as well as molecular genetic studies in plant physiology, biochemistry, and development.
Biosynthetic Pathways
Sets of enzymatic reactions occurring in organisms and that form biochemicals by making new covalent bonds.
Pentose Phosphate Pathway
An oxidative decarboxylation process that converts GLUCOSE-6-PHOSPHATE to D-ribose-5-phosphate via 6-phosphogluconate. The pentose product is used in the biosynthesis of NUCLEIC ACIDS. The generated energy is stored in the form of NADPH. This pathway is prominent in tissues which are active in the synthesis of FATTY ACIDS and STEROIDS.
Solid Phase Microextraction
A solventless sample preparation method, invented in 1989, that uses a fused silica fiber which is coated with a stationary phase. It is used for sample cleanup before using other analytical methods.
Tandem Mass Spectrometry
A mass spectrometry technique using two (MS/MS) or more mass analyzers. With two in tandem, the precursor ions are mass-selected by a first mass analyzer, and focused into a collision region where they are then fragmented into product ions which are then characterized by a second mass analyzer. A variety of techniques are used to separate the compounds, ionize them, and introduce them to the first mass analyzer. For example, for in GC-MS/MS, GAS CHROMATOGRAPHY-MASS SPECTROMETRY is involved in separating relatively small compounds by GAS CHROMATOGRAPHY prior to injecting them into an ionization chamber for the mass selection.
Databases, Factual
Extensive collections, reputedly complete, of facts and data garnered from material of a specialized subject area and made available for analysis and application. The collection can be automated by various contemporary methods for retrieval. The concept should be differentiated from DATABASES, BIBLIOGRAPHIC which is restricted to collections of bibliographic references.
Amino Acids
Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.
Plant Leaves
Expanded structures, usually green, of vascular plants, characteristically consisting of a bladelike expansion attached to a stem, and functioning as the principal organ of photosynthesis and transpiration. (American Heritage Dictionary, 2d ed)
Least-Squares Analysis
A principle of estimation in which the estimates of a set of parameters in a statistical model are those quantities minimizing the sum of squared differences between the observed values of a dependent variable and the values predicted by the model.

CSF metabolic and proteomic profiles in patients prodromal for psychosis. (1/1048)

BACKGROUND: The initial prodromal state of psychosis (IPS) is defined as an early disease stage prior to the onset of overt psychosis characterized by sub-threshold or more unspecific psychiatric symptoms. Little is known regarding the biochemical changes during this period. METHODOLOGY/PRINCIPAL FINDINGS: We investigated the metabolic/proteomic profiles of cerebrospinal fluid (CSF) of first-onset drug naive paranoid schizophrenia patients (n = 54) and individuals presenting with initial prodromal symptoms (n = 24), alongside healthy volunteers (n = 70) using proton nuclear magnetic resonance ((1)H-NMR) spectroscopy and surface enhanced laser desorption ionization (SELDI) mass spectrometry, respectively. Partial least square discriminant analysis (PLS-DA) showed that 36%/29% of IPS patients displayed proteomic/metabolic profiles characteristic of first-onset, drug naive schizophrenia, i.e., changes in levels of glucose and lactate as well as changes in a VGF-derived peptide (VGF23-62) and transthyretin protein concentrations. However, only 29% (n = 7) of the investigated IPS patients (who to date have been followed up for up to three years) have so far received a diagnosis of schizophrenia. The presence of biochemical alterations in the IPS group did not correlate with the risk to develop schizophrenia. CONCLUSIONS/SIGNIFICANCE: Our results imply that schizophrenia-related biochemical disease processes can be traced in CSF of prodromal patients. However, the biochemical disturbances identified in IPS patients, at least when measured at a single time point, may not be sufficient to predict clinical outcome.  (+info)

Metabolite quantification and high-field MRS in breast cancer. (2/1048)

In vivo 1H MRS is rapidly developing as a clinical tool for diagnosing and characterizing breast cancers. Many in vivo and in vitro experiments have demonstrated that alterations in concentrations of choline-containing metabolites are associated with malignant transformation. In recent years, considerable efforts have been made to evaluate the role of 1H MRS measurements of total choline-containing compounds in the management of patients with breast cancer. Current technological developments, including the use of high-field MR scanners and quantitative spectroscopic analysis methods, promise to increase the sensitivity and accuracy of breast MRS. This article reviews the literature describing in vivo MRS in breast cancer, with an emphasis on the development of high-field MR scanning and quantitative methods. Potential applications of these technologies for diagnosing suspicious lesions and monitoring response to chemotherapy are discussed.  (+info)

Perceiving molecular evolution processes in Escherichia coli by comprehensive metabolite and gene expression profiling. (3/1048)

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Metadegradomics: toward in vivo quantitative degradomics of proteolytic post-translational modifications of the cancer proteome. (4/1048)

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Metabolic profiling of an Echinostoma caproni infection in the mouse for biomarker discovery. (5/1048)

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Phenotyping murine models of non-alcoholic fatty liver disease through metabolic profiling of intact liver tissue. (6/1048)

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Gene module level analysis: identification to networks and dynamics. (7/1048)

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Genome-scale model for Clostridium acetobutylicum: Part II. Development of specific proton flux states and numerically determined sub-systems. (8/1048)

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Metabolome analysis for investigating host-gut microbiota interactions<...
TY - JOUR. T1 - Metabolome analysis for investigating host-gut microbiota interactions. AU - Chen, Michael X.. AU - Wang, San Yuan. AU - Kuo, Ching Hua. AU - Tsai, I. Lin. PY - 2019/3. Y1 - 2019/3. N2 - Dysbiosis of the gut microbiome is associated with host health conditions. Many diseases have shown to have correlations with imbalanced microbiota, including obesity, inflammatory bowel disease, cancer, and even neurodegeneration disorders. Metabolomics studies targeting small molecule metabolites that impact the host metabolome and their biochemical functions have shown promise for studying host-gut microbiota interactions. Metabolome analysis determines the metabolites being discussed for their biological implications in host-gut microbiota interactions. To facilitate understanding the critical aspects of metabolome analysis, this article reviewed (1) the sample types used in host-gut microbiome studies; (2) mass spectrometry (MS)-based analytical methods and (3) useful tools for MS-based data ...
https://tmu.pure.elsevier.com/en/publications/metabolome-analysis-for-investigating-host-gut-microbiota-interac
Long-term leisure-time physical activity and serum metabolome. | MRC-PHELong-term leisure-time physical activity and serum metabolome. | MRC-PHE
BACKGROUND: Long-term physical inactivity seems to cause many health problems. We studied whether persistent physical activity compared with inactivity has a global effect on serum metabolome toward reduced cardiometabolic disease risk.METHODS AND RESULTS: Sixteen same-sex twin pairs (mean age, 60 years) were selected from a cohort of twin pairs on the basis of their ,30-year discordance for physical activity. Persistently (≥5 years) active and inactive groups in 3 population-based cohorts (mean ages, 31-52 years) were also studied (1037 age- and sex-matched pairs). Serum metabolome was quantified by nuclear magnetic resonance spectroscopy. We used permutation analysis to estimate the significance of the multivariate effect combined across all metabolic measures; univariate effects were estimated by paired testing in twins and in matched pairs in the cohorts, and by meta-analysis over all substudies. Persistent physical activity was associated with the multivariate metabolic profile in the ...
http://www.environment-health.ac.uk/publications/long-term-leisure-time-physical-activity-and-serum-metabolome
Archive ouverte HAL - Human gut microbes impact host serum metabolome and insulin sensitivityArchive ouverte HAL - Human gut microbes impact host serum metabolome and insulin sensitivity
Insulin resistance is a forerunner state of ischaemic cardiovascular disease and type 2 diabetes. Here we show how the human gut microbiome impacts the serum metabolome and associates with insulin resistance in 277 non-diabetic Danish individuals. The serum metabolome of insulin-resistant individuals is characterized by increased levels of branched-chain amino acids (BCAAs), which correlate with a gut microbiome that has an enriched biosynthetic potential for BCAAs and is deprived of genes encoding bacterial inward transporters for these amino acids. Prevotella copri and Bacteroides vulgatus are identified as the main species driving the association between biosynthesis of BCAAs and insulin resistance, and in mice we demonstrate that P. copri can induce insulin resistance, aggravate glucose intolerance and augment circulating levels of BCAAs. Our findings suggest that microbial targets may have the potential to diminish insulin resistance and reduce the incidence of common metabolic and cardiovascular
https://hal.archives-ouvertes.fr/hal-01594855?gathStatIcon=true
The Effect of Acyclic Retinoid on the Metabolomic Profiles of Hepatocytes and Hepatocellular Carcinoma CellsThe Effect of Acyclic Retinoid on the Metabolomic Profiles of Hepatocytes and Hepatocellular Carcinoma Cells
Background/Purpose Acyclic retinoid (ACR) is a promising chemopreventive agent for hepatocellular carcinoma (HCC) that selectively inhibits the growth of HCC cells (JHH7) but not normal hepatic cells (Hc). To better understand the molecular basis of the selective anti-cancer effect of ACR, we performed nuclear magnetic resonance (NMR)-based and capillary electrophoresis time-of-flight mass spectrometry (CE-TOFMS)-based metabolome analyses in JHH7 and Hc cells after treatment with ACR. Methodology/Principal Findings NMR-based metabolomics revealed a distinct metabolomic profile of JHH7 cells at 18 h after ACR treatment but not at 4 h after ACR treatment. CE-TOFMS analysis identified 88 principal metabolites in JHH7 and Hc cells after 24 h of treatment with ethanol (EtOH) or ACR. The abundance of 71 of these metabolites was significantly different between EtOH-treated control JHH7 and Hc cells, and 49 of these metabolites were significantly down-regulated in the ACR-treated JHH7 cells compared to the
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0082860
Quantitative Metabolome Profiling of Colon and Stomach Cancer Microenvironment by Capillary Electrophoresis Time-of-Flight Mass...Quantitative Metabolome Profiling of Colon and Stomach Cancer Microenvironment by Capillary Electrophoresis Time-of-Flight Mass...
One obvious question raised is the origin of these amino acids. Under limited blood supply, two main sources of amino acids can be conceived: one is the degradation of extracellular matrix particularly by matrix metalloproteinases and the other is the autophagic degradation of preexisting intracellular proteins. In this perspective, it is notable that hydroxyproline concentration was significantly higher in tumor tissues than in their normal counterparts (P = 0.0005 in colon and P = 0.0025 in stomach tissues). Hydroxyproline is abundant in collagen and is posttranslationally produced from proline, which suggests that the higher concentration of hydroxyproline in tumor tissues is indicative of excess degradation of collagen ( 35). Autophagy is another possible source of amino acids, as it is well-documented that autophagy liberates and thereby increases the free amino acid pools ( 36, 37). We also have found recently that autophagy seems essential for colon cancer cell survival ( 38) and is ...
http://cancerres.aacrjournals.org/content/69/11/4918.long
YMDB: the Yeast Metabolome DatabaseYMDB: the Yeast Metabolome Database
The Yeast Metabolome Database (YMDB, http://www.ymdb.ca) is a richly annotated metabolomic database containing detailed information about the metabolome of Saccharomyces cerevisiae. Modeled closely after the Human Metabolome Database, the YMDB contains |2000 metabolites with links to 995 differ …
https://pubmed.ncbi.nlm.nih.gov/22064855/?dopt=Abstract
Urine Metabolome: DownloadsUrine Metabolome: Downloads
The Urine Metabolome Database is offered to the public as a freely available resource. Use and re-distribution of the data, in whole or in part, for commercial purposes requires explicit permission of the authors and explicit acknowledgment of the source material (Urine Metabolome Database) and the original publication (see below). We ask that users who download significant portions of the database cite the Urine Metabolome Database paper in any resulting publications.. How to cite the Urine Metabolome Database ...
https://urinemetabolome.ca/downloads
Metabolome - definition of metabolome by The Free DictionaryMetabolome - definition of metabolome by The Free Dictionary
Define metabolome. metabolome synonyms, metabolome pronunciation, metabolome translation, English dictionary definition of metabolome. n. The complete set of chemical compounds involved in an organisms metabolism. me·tab′o·lom′ic adj. American Heritage® Dictionary of the English Language,...
https://www.thefreedictionary.com/metabolome
Human Metabolome Database: 13C NMR Spectrum (HMDB0000042)Human Metabolome Database: 13C NMR Spectrum (HMDB0000042)
Wishart DS, Knox C, Guo AC, Eisner R, Young N, Gautam B, Hau DD, Psychogios N, Dong E, Bouatra S, Mandal R, Sinelnikov I, Xia J, Jia L, Cruz JA, Lim E, Sobsey CA, Shrivastava S, Huang P, Liu P, Fang L, Peng J, Fradette R, Cheng D, Tzur D, Clements M, Lewis A, De Souza A, Zuniga A, Dawe M, Xiong Y, Clive D, Greiner R, Nazyrova A, Shaykhutdinov R, Li L, Vogel HJ, Forsythe I: HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 Jan;37(Database issue):D603-10. doi: 10.1093/nar/gkn810. Epub 2008 Oct 25. [PubMed: 18953024 ...
https://hmdb.ca/spectra/nmr_one_d/1126
Human Metabolome Technologies America (HMT)Human Metabolome Technologies America (HMT)
Human Metabolome Technologies America (HMT) is a full-service CRO, offering a wide range of analytics platforms and customization options based on metabolomics.
https://www.newprotein.net/supplier/human-metabolome-technologies-america-hmt
AtMetExpress overview (Arabidopsis thaliana) - WikiPathwaysAtMetExpress overview (Arabidopsis thaliana) - WikiPathways
Since early 2000, a number of metabolome analyses have been demonstrated using combined hyphenated chromatographic and mass spectral methods as well as nuclear-magnetic-resonance. Although metabolite profiling experiments are becoming routine in many research groups, making the studies remains expensive and laborious. While the metabolomics community is working towards the setup of sharing metabolome data, mining publicly available information and demonstrating the richness of integration of multiple metabolome datasets remain largely unexploited. The aims of this project are (1) to establish a new web-based platform for metabolome meta-analysis and (2) to use these sets of combined metabolite levels to explore the diversity of complex metabolic networks in the model plant, Arabidopsis thaliana. We constructed our database, called AtMetExpress (http://prime.psc.riken.jp/AtMetExpress/), to store the metabolome information ...
https://www.wikipathways.org/index.php?title=Pathway:WP3622&oldid=84719
Metformin and DPP-4 inhibitor differentially modulate the intestinal microbiota and plasma metabolome of metabolically...Metformin and DPP-4 inhibitor differentially modulate the intestinal microbiota and plasma metabolome of metabolically...
Background Recent evidence indicates that the gut microbiota is altered considerably by a variety of commonly prescribed medications. This study assessed the impact of two antidiabetic therapeutics on the gut microbiota and markers of cardiometabolic disease in metabolically dysfunctional mice. Materials & Methods C57BL/6 mice were fed a high-fat diet for 24-weeks while receiving one of two antidiabetic therapeutics - metformin or DPP-4 inhibitor, PKF-275-055 - for the final 12 weeks. Mice were assessed for weight gain, glucose and cholesterol metabolism, and adiposity. In addition, caecal microbiota was analysed by 16S compositional sequencing and plasma metabolome was analysed by LC-MS/MS. Results Both therapeutics had similar metabolic effects, attenuating mesenteric adiposity, improving cholesterol metabolism and insulin sensitivity. However, multivariate analyses of microbiota and metabolomics data revealed clear divergence of the therapeutic groups. While both metformin and PKF-275-055 ...
https://openpub.fmach.it/handle/10449/58827
Human Metabolome Database: Showing metabocard for Butyl 3-methylbutanoate (HMDB0032042)Human Metabolome Database: Showing metabocard for Butyl 3-methylbutanoate (HMDB0032042)
Raman M, Ahmed I, Gillevet PM, Probert CS, Ratcliffe NM, Smith S, Greenwood R, Sikaroodi M, Lam V, Crotty P, Bailey J, Myers RP, Rioux KP: Fecal microbiome and volatile organic compound metabolome in obese humans with nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol. 2013 Jul;11(7):868-75.e1-3. doi: 10.1016/j.cgh.2013.02.015. Epub 2013 Feb 27. [PubMed:23454028 ...
https://hmdb.ca/metabolites/HMDB0032042
KAKEN - Research Projects | Understanding cancer cell metabolism and biomarker discovery using metabolome analysis (KAKENHI...KAKEN - Research Projects | Understanding cancer cell metabolism and biomarker discovery using metabolome analysis (KAKENHI...
Principal Investigator：SOGA Tomoyoshi, Project Period (FY)：2010-04-01 - 2015-03-31, Research Category：Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Project Area：Integrative Systems Understanding of Cancer for Advanced Diagnosis, Therapy and Prevention
https://kaken.nii.ac.jp/en/grant/KAKENHI-PLANNED-22134007/
First Kit for Comprehensive Metabolome AnalysisFirst Kit for Comprehensive Metabolome Analysis
Thermo Fisher Scientific and BIOCRATES Life Sciences launch a ready-to-use kit for accurate and confident metabolic phenotyping on high-resolution mass spectrometry instruments.
https://www.technologynetworks.com/neuroscience/product-news/first-kit-for-comprehensive-metabolome-analysis-289523
Transcriptome sequencing and metabolome analysis of food habits domestication from live prey fish to artificial diets in...Transcriptome sequencing and metabolome analysis of food habits domestication from live prey fish to artificial diets in...
Background: As economical traits, food habits domestication can reduce production cost in aquaculture. However, the molecular mechanism underlying food habits domestication has remained elusive. Mandarin fish (Siniperca chuatsi) only feed on live prey fish and refuse ...
https://www.researchsquare.com/article/rs-19835/v2
Metabolites | Free Full-Text | Optimized Method for Untargeted Metabolomics Analysis of MDA-MB-231 Breast Cancer CellsMetabolites | Free Full-Text | Optimized Method for Untargeted Metabolomics Analysis of MDA-MB-231 Breast Cancer Cells
Cancer cells often have dysregulated metabolism, which is largely characterized by the Warburg effect-an increase in glycolytic activity at the expense of oxidative phosphorylation-and increased glutamine utilization. Modern metabolomics tools offer an efficient means to investigate metabolism in cancer cells. Currently, a number of protocols have been described for harvesting adherent cells for metabolomics analysis, but the techniques vary greatly and they lack specificity to particular cancer cell lines with diverse metabolic and structural features. Here we present an optimized method for untargeted metabolomics characterization of MDA-MB-231 triple negative breast cancer cells, which are commonly used to study metastatic breast cancer. We found that an approach that extracted all metabolites in a single step within the culture dish optimally detected both polar and non-polar metabolite classes with higher relative abundance than methods that involved removal of cells from the dish. We show that
http://www.mdpi.com/2218-1989/6/4/30
Urine metabolome profiling of immune-mediated inflammatory diseasesUrine metabolome profiling of immune-mediated inflammatory diseases
Background: immune-mediated inflammatory diseases (IMIDs) are a group of complex and prevalent diseases where disease diagnostic and activity monitoring is highly challenging. The determination of the metabolite profiles of biological samples is becoming a powerful approach to identify new biomarkers of clinical utility. In order to identify new metabolite biomarkers of diagnosis and disease activity, we have performed the first large-scale profiling of the urine metabolome of the six most prevalent IMIDs: rheumatoid arthritis, psoriatic arthritis, psoriasis, systemic lupus erythematosus, Crohns disease, and ulcerative colitis. Methods: using nuclear magnetic resonance, we analyzed the urine metabolome in a discovery cohort of 1210 patients and 100 controls. Within each IMID, two patient subgroups were recruited representing extreme disease activity (very high vs. very low). Metabolite association analysis with disease diagnosis and disease activity was performed using multivariate linear ...
http://www.recercat.cat/handle/2072/302892
Steroid metabolome analysis reveals prevalent glucocorticoid excess in primary aldosteronism. - SCNi
BACKGROUND: Adrenal aldosterone excess is the most common cause of secondary hypertension and is associated with increased cardiovascular morbidity. However, adverse metabolic risk in primary aldosteronism extends beyond hypertension, with increased rates of insulin resistance, type 2 diabetes, and osteoporosis, which cannot be easily explained by aldosterone excess. METHODS: We performed mass spectrometry-based analysis of a 24-hour urine steroid metabolome in 174 newly diagnosed patients with primary aldosteronism (103 unilateral adenomas, 71 bilateral adrenal hyperplasias) in comparison to 162 healthy controls, 56 patients with endocrine inactive adrenal adenoma, 104 patients with mild subclinical, and 47 with clinically overt adrenal cortisol excess. We also analyzed the expression of cortisol-producing CYP11B1 and aldosterone-producing CYP11B2 enzymes in adenoma tissue from 57 patients with aldosterone-producing adenoma, employing immunohistochemistry with digital image analysis. RESULTS: Primary
https://www.scni.ox.ac.uk/publications/963084
Microbiosci Provides Microbial Metabolomics Services with Advanced Instruments and State-of-the-art Multivariate Data Analyses ...Microbiosci Provides Microbial Metabolomics Services with Advanced Instruments and State-of-the-art Multivariate Data Analyses ...
As a service provider of microbial metabolomics, Microbiosci uses advanced instruments and the latest multivariate data analysis. Metabolomics aims to identify biomarkers, clarify the mode of action, and characterize products and processes. Microbioscis metabolomics solutions based on LC-MS, GC-MS and NMR fully meet the requirements of integrated metabolic profiling, sample throughput, compound identification, verification and quantification. In order to obtain metabolome data representing the physiological state of microorganisms, validated protocols and analyses are essential. The solutions provided by Mirobiosci are tailor-made for corresponding research purposes, combining innovative hardware with the versatility of data processing.. Microbiosci provides non-target metabolomics services. With its advanced facilities with experienced scientists, it will provide unparalleled expertise to assist researchers in non-target metabolomics analysis. In addition, Microbiosci can also provide a ...
http://www.cochinreporter.in/story/90002/microbiosci-provides-microbial-metabolomics-services-with-advanced-instruments-and-stateoftheart-multivariate-data-analyses.html
Microbiosci Provides Microbial Metabolomics Services with Advanced Instruments and State-of-the-art Multivariate Data Analyses ...Microbiosci Provides Microbial Metabolomics Services with Advanced Instruments and State-of-the-art Multivariate Data Analyses ...
As a service provider of microbial metabolomics, Microbiosci uses advanced instruments and the latest multivariate data analysis. Metabolomics aims to identify biomarkers, clarify the mode of action, and characterize products and processes. Microbioscis metabolomics solutions based on LC-MS, GC-MS and NMR fully meet the requirements of integrated metabolic profiling, sample throughput, compound identification, verification and quantification. In order to obtain metabolome data representing the physiological state of microorganisms, validated protocols and analyses are essential. The solutions provided by Mirobiosci are tailor-made for corresponding research purposes, combining innovative hardware with the versatility of data processing.. Microbiosci provides non-target metabolomics services. With its advanced facilities with experienced scientists, it will provide unparalleled expertise to assist researchers in non-target metabolomics analysis. In addition, Microbiosci can also provide a ...
http://news.tallahasseejournal.com/story/316326/microbiosci-provides-microbial-metabolomics-services-with-advanced-instruments-and-stateoftheart-multivariate-data-analyses.html
Quantitative metabolome analysis using capillary electrophoresis mass spectrometry | Read by QxMDQuantitative metabolome analysis using capillary electrophoresis mass spectrometry | Read by QxMD
A new approach for the comprehensive and quantitative analysis of charged metabolites by capillary electrophoresis mass spectrometry (CE-MS) is proposed. Metabolites are first separated by CE based on charge and size and then selectively detected using MS by monitoring over a large range of m/z values. This method enabled the determination of 352 metabolic standards and its utility was demonstrated in the analysis of 1692 metabolites from Bacillus subtilis extracts, revealing significant changes in metabolites during B. subtilis sporulation ...
https://read.qxmd.com/read/14582645/quantitative-metabolome-analysis-using-capillary-electrophoresis-mass-spectrometry
Towards quantitative metabolome analysis | BMC Systems Biology | Full TextTowards quantitative metabolome analysis | BMC Systems Biology | Full Text
Strong distinctions in metabolite concentrations were found with the quantification strategies applied. For dilutions ranging from 1:2 to 1:20 internal calibration and isotope dilution mass spectrometry were found to be most suitable for the compensation of matrix effects. Further more, the results showed that U13C4-aspartate as internal standard could be used for various amino acids in the chromatographic run. Using isotope dilution, where each metabolite has its own labelled analogue, the linear range of the calibration curve and the coefficient of correlation (up to 0.9999) were improved. The procedure of standard addition was only necessary for very low concentrated metabolites. To avoid this time consuming procedure, samples can as well be concentrated and measured via internal calibration instead. External calibration was sufficient for biological samples in dilutions of 1:20 or higher, because the measurements were hardly influenced by matrix effects. ...
https://bmcsystbiol.biomedcentral.com/articles/10.1186/1752-0509-1-S1-P14
Using Metabolomic Profiles as Biomarkers for Insulin Resistance in Childhood Obesity: A Systematic ReviewUsing Metabolomic Profiles as Biomarkers for Insulin Resistance in Childhood Obesity: A Systematic Review
A growing body of evidence has shown the intimate relationship between metabolomic profiles and insulin resistance (IR) in obese adults, while little is known about childhood obesity. In this review, we searched available papers addressing metabolomic profiles and IR in obese children from inception to February 2016 on MEDLINE, Web of Science, the Cochrane Library, ClinicalTrials.gov, and EMASE. HOMA-IR was applied as surrogate markers of IR and related metabolic disorders at both baseline and follow-up. To minimize selection bias, two investigators independently completed this work. After critical selection, 10 studies (including 2,673 participants) were eligible and evaluated by using QUADOMICS for quality assessment. Six of the 10 studies were classified as “high quality.” Then we generated all the metabolites identified in each study and found amino acid metabolism and lipid metabolism were the main affected metabolic pathways in obese children. Among identified metabolites, branched
https://www.hindawi.com/journals/jdr/2016/8160545/
Frontiers | The Plant Growth-Promoting Fungus MF23 (Mycena sp.) Increases Production of Dendrobium officinale (Orchidaceae) by...Frontiers | The Plant Growth-Promoting Fungus MF23 (Mycena sp.) Increases Production of Dendrobium officinale (Orchidaceae) by...
Dendrobium officinale Kimura et Migo is a traditional and scarce medicinal orchid in China. Mycorrhizal fungi could supply nitrogen (N) to orchids for seed germination and seedling recruitment. However, the N transport mechanism between orchids and the fungus is poorly understand. Early studies found that the fungus MF23 (Mycena sp.) could promote the growth of D. officinale. To better dissect the molecular interactions involved in N transport between D. officinale and MF23, transcriptome and metabolome analyses were conducted on conventional and mycorrhizal cultivations of D. officinale. Moreover, validation tests were carried out in the greenhouse to measure net fluxes of NO3− and NH4+ of roots by a non-invasive micro-test technology (NMT), determine N assimilation enzyme activity by the ELISA, and analyze the expression level of differentially expressed genes (DEGs) of N transporters and DEGs involved in N metabolism by RT-qPCR. Combined transcriptome and metabolome analyses showed that MF23 may
https://www.frontiersin.org/articles/10.3389/fpls.2021.693561/full
Global gas chromatography/time-of-flight mass spectrometry (GC/TOFMS)-based metabonomic profiling of lyophilized human feces |...Global gas chromatography/time-of-flight mass spectrometry (GC/TOFMS)-based metabonomic profiling of lyophilized human feces |...
Gas chromatography mass spectrometry (GC/MS)-based fecal metabonomics represents a powerful systems biology approach for elucidating metabolic biomarkers of lower gastrointestinal tract (GIT) diseases. Unlike metabolic profiling of fecal water, the profiling of complete fecal material remains under-explored. Here, a gas chromatography/time-of-flight mass spectrometry (GC/TOFMS) method was developed and validated for the global metabonomic profiling of human feces. Fecal and fecal water metabotypes were also profiled and compared. Additionally, the unclear influence of blood in stool on the fecal metabotype was investigated unprecedentedly. Eighty milligram of lyophilized feces was ultrasonicated with 1mL of methanol:water (8:2) for 30min, followed by centrifugation, drying of supernatant, oximation and trimethylsilylation for 45min. Lyophilized feces demonstrated a more comprehensive metabolic coverage than fecal water, based on the number of chromatographic peaks. Principal component analysis ...
https://scholarbank.nus.edu.sg/handle/10635/105982
Development and broad application of a mass spectrometry based metabolomics platform
Metabolomics is a comprehensive analysis of small molecules, or metabolites, in a system. Metabolomics is a hypothesis-generating experiment and offers an unbiased analysis of cell metabolism that can aid in the understanding of fundamental biological processes. Metabolomics is widely and broadly applicable in the biological sciences and has been used to study gene function, elucidate mechanisms of drug action, develop novel therapeutics, and to better understand disease states. This dissertation presents studies aimed at developing and determining the suitability of a mass spectrometry based untargeted metabolomics platform. Four chapters of original research are presented in this dissertation. The first chapter describes the development of a liquid chromatography-quadrupole-time-of-flight mass spectrometry metabolomics platform and details the various steps involved in a typical metabolomics experiment including metabolite extraction/sample preparation, metabolite separation and data ...
https://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/ng451p19r
The longitudinal cerebrospinal fluid metabolomic profile of amyotrophic lateral sclerosis. - Oxford Neuroscience
Neurochemical biomarkers are urgently sought in ALS. Metabolomic analysis of cerebrospinal fluid (CSF) using proton nuclear magnetic resonance ((1)H-NMR) spectroscopy is a highly sensitive method capable of revealing nervous system cellular pathology. The (1)H-NMR CSF metabolomic signature of ALS was sought in a longitudinal cohort. Six-monthly serial collection was performed in ALS patients across a range of clinical sub-types (n = 41) for up to two years, and in healthy controls at a single time-point (n = 14). A multivariate statistical approach, partial least squares discriminant analysis, was used to determine differences between the NMR spectra from patients and controls. Significantly predictive models were found using those patients with at least one years interval between recruitment and the second sample. Glucose, lactate, citric acid and, unexpectedly, ethanol were the discriminating metabolites elevated in ALS. It is concluded that (1)H-NMR captured the CSF metabolomic signature associated
https://www.neuroscience.ox.ac.uk/publications/529175
VOCCluster: Untargeted Metabolomics Feature Clustering Approach for Clinical Breath Gas Chromatography-Mass Spectroscopy Data<...
TY - UNPB. T1 - VOCCluster: Untargeted Metabolomics Feature Clustering Approach for Clinical Breath Gas Chromatography-Mass Spectroscopy Data. AU - Alkhalifah, Yaser. AU - Phillips, Iain. AU - Soltoggio, Andrea. AU - Darnley, Kareen. AU - Nailon, William Henry. AU - McLaren, Duncan. AU - Eddleston, Michael. AU - Thomas, Paul AU - Salman, Dahlia. PY - 2019/2/18. Y1 - 2019/2/18. M3 - Working paper. T3 - ChemRxiv. BT - VOCCluster: Untargeted Metabolomics Feature Clustering Approach for Clinical Breath Gas Chromatography-Mass Spectroscopy Data. ER - ...
https://www.research.ed.ac.uk/en/publications/voccluster-untargeted-metabolomics-feature-clustering-approach-fo-2
Sphingolipid, fatty acid and phospholipid metabolites are associated with disease severity and mTOR inhibition in...Sphingolipid, fatty acid and phospholipid metabolites are associated with disease severity and mTOR inhibition in...
Lymphangioleiomyomatosis (LAM) is a rare multisystem disease almost exclusively affecting women which causes loss of lung function, lymphatic abnormalities and angiomyolipomas. LAM occurs sporadically and in people with tuberous sclerosis complex (TSC). Loss of TSC gene function leads to dysregulated mechanistic target of rapamycin (mTOR) signalling. As mTOR is a regulator of lipid and nucleotide synthesis, we hypothesised that the serum metabolome would be altered in LAM and related to disease severity and activity.Ultrahigh performance liquid chromatography-tandem mass spectroscopy was used to examine the serum metabolome of 79 closely phenotyped women with LAM, including 29 receiving treatment with an mTOR inhibitor and 43 healthy control women.Sphingolipid, fatty acid and phospholipid metabolites were associated with FEV1 in women with LAM (eg, behenoyl sphingomyelin adjusted (adj.) p=8.10 × 10-3). Those with higher disease-burden scores had abnormalities in fatty acid, phospholipid and ...
https://www.onmedica.com/posts/sphingolipid-fatty-acid-and-phospholipid-metabolites-are-associated-with-disease-severity-and-mtor-inhibition-in-lymphangioleiomyomatosis
British Library EThOS: Probabilistic modelling of liquid chromatography time-of-flight mass spectrometryBritish Library EThOS: Probabilistic modelling of liquid chromatography time-of-flight mass spectrometry
Liquid Chromatography Time-of-Flight Mass Spectrometry (LC-TOFMS) is an analytical platform that is widely used in the study of biological mixtures in the rapidly growing fields of proteomics and metabolomics. The development of statistical methods for the analysis of the very large data-sets that are typically produced in LC-TOFMS experiments is a very active area of research. However, the theoretical basis on which these methods are built is currently rather thin and as a result, inferences regarding the samples analysed are generally drawn in a somewhat qualitative fashion. This thesis concerns the development of a statistical formalism that can be used to describe and analyse the data produced in an LC-TOFMS experiment. This is done through the derivation of a number of probability distributions, each corresponding to a different level of approximation of the distribution of the empirically obtained data. Using such probabilistic models, statistically rigorous methods are developed and ...
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.535457
Frontiers | Serum Metabolomic Analysis of Coronary Heart Disease Patients with Stable Angina Pectoris Subtyped by Traditional...Frontiers | Serum Metabolomic Analysis of Coronary Heart Disease Patients with Stable Angina Pectoris Subtyped by Traditional...
To improve the treatment of patients with coronary heart disease (CHD), personalized treatments based on potential biomarkers could make a difference. To investigate if such potential biomarkers could be found for CHD inhomogeneous, we combined traditional Chinese medicine based diagnosis with untargeted and targeted metabolomics analyses. Shi and Xu patient subtype groups of CHD with angina pectoris were identified. Different metabolites including lipids, fatty acids and amino acids were further analyzed with targeted metabolomics and mapped to disease-related pathways. The long-chain unsaturated lipids ceramides metabolism, bile acid metabolism were differentially affected in the Xu subtype groups. While, Shi-subtype patients seemed to show inflammation, anomalous levels of bioactive phospholipids and antioxidant molecules. Furthermore, variations in the endothelial damage response and energy metabolism found based on ELISA analysis are the key divergence points between different CHD subtypes. The
https://www.frontiersin.org/articles/10.3389/fphar.2021.664320/full
Metabolomic Analysis of Exhaled Breath Condensates in Patients With COPD and Bronchiectasis - Full Text View - ClinicalTrials...Metabolomic Analysis of Exhaled Breath Condensates in Patients With COPD and Bronchiectasis - Full Text View - ClinicalTrials...
Metabolomics is a large-scale approach to monitoring as many as possible of the compounds involved in cellular processes in a single assay to derive metabolic profiles. Compared with genomics or proteomics, metabolomics reflects changes in phenotype and therefore function. Collection of exhaled breath condensate (EBC) is a newly developed, noninvasive method that may allow clinicians and researchers to assess biochemical profiles in the alveolar lining fluid. The aims of this study are: (1)Collecting and metabolomic profiling of the EBCs from patients with COPD/bronchiectasis; (2) Comparing the profiles of these patients obtained during stable and acute exacerbation periods; (3) Comparing the profiles of these patients with and without Pseudomonas colonization/infection; (4) Correlation of EBC metabolomic profiles with clinical phenotypes, severity and outcomes of these patients ...
https://clinicaltrials.gov/ct2/show/NCT01410422?recr=Open&cond=%22Bronchiectasis%22&rank=3
Serum metabolomic biomarkers of dementia.Serum metabolomic biomarkers of dementia.
AIMS: This study compared serum metabolites of demented patients (Alzheimers disease and vascular dementia) and controls, and explored serum metabolite profiles of nondemented individuals 5 years preceding the diagnosis.. METHODS: Cognitively healthy participants were followed up for 5-20 years. Cognitive assessment, serum sampling, and diagnosis were completed every 5 years. Multivariate analyses were conducted on the metabolite profiles generated by gas chromatography/time-of-flight mass spectrometry.. RESULTS: A significant group separation was found between demented patients and controls, and between incident cases and controls. Metabolites that contributed in both analyses were 3,4-dihydroxybutanoic acid, docosapentaenoic acid, and uric acid.. CONCLUSIONS: Serum metabolite profiles are altered in demented patients, and detectable up to 5 years preceding the diagnosis. Blood sampling can make an important contribution to the early prediction of conversion to dementia.. ...
http://su.diva-portal.org/smash/record.jsf?pid=diva2:779106
Untargeted metabolomics unveil alterations of biomembranes permeability in human HaCaT keratinocytes upon 60 GHz millimeter...Untargeted metabolomics unveil alterations of biomembranes permeability in human HaCaT keratinocytes upon 60 GHz millimeter...
A joint metabolomic and lipidomic workflow is used to account for a potential effect of millimeter waves (MMW) around 60 GHz on biological tissues. For this purpose, HaCaT human keratinocytes were exposed at 60.4 GHz with an incident power density of 20 mW/cm², this value corresponding to the upper local exposure limit for general public in the context of a wide scale deployment of MMW technologies and devices. After a 24h-exposure, endo- and extracellular extracts were recovered to be submitted to an integrative UPLC-Q-Exactive metabolomic and lipidomic workflow. R-XCMS data processing and subsequent statistical treatment led to emphasize a limited number of altered features in lipidomic sequences and in intracellular metabolomic analyses, whatever the ionization mode (i.e 0 to 6 dysregulated features). Conversely, important dysregulations could be reported in extracellular metabolomic profiles with 111 and 99 frames being altered upon MMW exposure in positive and negative polarities, respectively.
https://www.nature.com/articles/s41598-019-45662-6?error=cookies_not_supported&code=74b83cb2-957a-40d1-a10a-c5c33bca7593
Metabolomics Profiling of Green Tea Leaves using LC/MS and GC/MS | SelectScienceMetabolomics Profiling of Green Tea Leaves using LC/MS and GC/MS | SelectScience
This Application Note presents the profiling of green tea leaves as an example of one application of the metabolome analysis technique using LC/MS and GC/MS. A search of the substances believed to play roles in product quality was conducted, and a quality prediction model was constructed based on the results.
http://www.selectscience.net/application-articles/metabolomics-profiling-of-green-tea-leaves-using-lcms-and-gcms/?artID=21890
The free fatty acid metabolome in cerebral ischemia following human mesenchymal stem cell transplantation in rats<...The free fatty acid metabolome in cerebral ischemia following human mesenchymal stem cell transplantation in rats<...
TY - JOUR. T1 - The free fatty acid metabolome in cerebral ischemia following human mesenchymal stem cell transplantation in rats. AU - Paik, Man Jeong. AU - Li, Wen Yu. AU - Ahn, Young Hwan. AU - Lee, Phil Hyu. AU - Choi, Sangdun. AU - Kim, Kyoung Rae. AU - Kim, Yong Man. AU - Bang, Oh Young. AU - Lee, Gwang. PY - 2009/4/1. Y1 - 2009/4/1. N2 - Background: Mesenchymal stem cells (MSCs) have the potential to promote brain repair and improve recovery following stroke. We investigated changes in free fatty acids (FFAs) following intravenous human MSC (hMSC) transplantation into rats that had undergone transient middle cerebral artery occlusion (MCAo). Methods: Rats were subjected to 2-hours MCAo, followed by intravenous transplantation of hMSC or phosphate-buffered saline (PBS) at one day after MCAo. All rats were sacrificed 5 days after MCAo. Metabolic profiling of free fatty acids (FFAs) level was assessed in plasma and brain from control rats (n = 8), PBS-treated MCAo rats (n = 6), and ...
https://yonsei.pure.elsevier.com/en/publications/the-free-fatty-acid-metabolome-in-cerebral-ischemia-following-hum
Metabolomic Profiling of Neurospora crassa Fungi | Sigma-AldrichMetabolomic Profiling of Neurospora crassa Fungi | Sigma-Aldrich
Metabolomic Profiling of Neurospora crassa Fungi Using HILIC and Reversed-Phase LC-MS with high-resolution Ascentis Express HPLC columns.
https://www.sigmaaldrich.com/technical-documents/articles/reporter-us/metabolomic-profiling.html
Nutrients | Free Full-Text | The Effect of Gestational and Lactational Age on the Human Milk Metabolome | HTMLNutrients | Free Full-Text | The Effect of Gestational and Lactational Age on the Human Milk Metabolome | HTML
Human milk is the ideal nutrition source for healthy infants during the first six months of life and a detailed characterisation of the composition of milk from mothers that deliver prematurely (|37 weeks gestation), and of how human milk changes during lactation, would benefit our understanding of the nutritional requirements of premature infants. Individual milk samples from mothers delivering prematurely and at term were collected. The human milk metabolome, established by nuclear magnetic resonance (NMR) spectroscopy, was influenced by gestational and lactation age. Metabolite profiling identified that levels of valine, leucine, betaine, and creatinine were increased in colostrum from term mothers compared with mature milk, while those of glutamate, caprylate, and caprate were increased in mature term milk compared with colostrum. Levels of oligosaccharides, citrate, and creatinine were increased in pre-term colostrum, while those of caprylate, caprate, valine, leucine, glutamate, and pantothenate
http://www.mdpi.com/2072-6643/8/5/304/htm
Serum metabolomic analysis of the effect of exercise on nonalcoholic fatty liver disease in: Endocrine Connections Volume 8...Serum metabolomic analysis of the effect of exercise on nonalcoholic fatty liver disease in: Endocrine Connections Volume 8...
NAFLD is considered a hepatic manifestation of metabolic syndrome and is strongly associated with insulin resistance (15, 16). Our previous clinical trial contributed novel findings concerning the effects of long-term exercise on NAFLD in several aspects; the primary outcomes were IHTG reduction and weight loss. This present work focused on a large panel of metabolites in the serum after the exercise intervention, which was performed for the first time using an untargeted UPLC-Q-TOF/MS analysis based on a single serum sample. Making use of the full spectrum of analytes and metabolic profiling combined with pattern recognition techniques, we performed a metabolic analysis and clearly discriminated the characteristics of NAFLD patients with/without exercise. Among these identified altered metabolites, most belonged to glycerophospholipid and sphingolipids, which were associated with the glycerophospholipid and sphingolipid metabolic pathways, respectively.. Glycerophospholipids alone provided the ...
https://ec.bioscientifica.com/view/journals/ec/8/4/EC-19-0023.xml?rskey=ay86os&result=2
Postprandial differences in the plasma metabolome of healthy Finnish subjects after intake of a sourdough fermented endosperm...Postprandial differences in the plasma metabolome of healthy Finnish subjects after intake of a sourdough fermented endosperm...
The mechanism behind the lowered postprandial insulin demand observed after rye bread intake compared to wheat bread is unknown. The aim of this study was to use the metabolomics approach to identify potential metabolites related to amino acid metabolism involved in this mechanism. A sourdough fermented endosperm rye bread (RB) and a standard white wheat bread (WB) as a reference were served in random order to 16 healthy subjects. Test bread portions contained 50 g available carbohydrate. In vitro hydrolysis of starch and protein were performed for both test breads. Blood samples for measuring glucose and insulin concentrations were drawn over 4 h and gastric emptying rate (GER) was measured. Changes in the plasma metabolome were investigated by applying a comprehensive two-dimensional gas chromatography coupled to time-of-flight mass spectrometry metabolomics platform (GC×GC-TOF-MS). Plasma insulin response to RB was lower than to WB at 30 min (P = 0.004), 45 min (P = 0.002) and 60 min (P | 0.001)
https://nutritionj.biomedcentral.com/articles/10.1186/1475-2891-10-116
P. aeruginosa Metabolome Database: Glyoxylic acid (PAMDB000043)
Glyoxylic acid or oxoacetic acid is an organic compound that is both an aldehyde and a carboxylic acid. It is an intermediate of the glyoxylate cycle, which enables certain organisms to convert fatty acids into carbohydrates.The conjugate base of gloxylic acid is known as glyoxylate. This compound is an intermediate of the glyoxylate cycle, which enables organisms, such as bacteria, fungi and plants to convert fatty acids into carbohydrates. Glyoxylate is the byproduct of the amidation process in biosynthesis of several amidated peptides. The glyoxylate cycle is a metabolic pathway occurring in plants, and several microorganisms, such as Pseudomonas aeruginosa and yeast ...
http://pseudomonas.umaryland.edu/PAMDB?MetID=PAMDB000043
Livestock Metabolome Database: Showing metabocard for Creatine (LMDB00029)
Creatine is an amino acid that occurs in vertebrate tissues and in urine. In muscle tissue, creatine generally occurs as phosphocreatine. Creatine is excreted as creatinine in the urine. Creatine functions as part of the cells energy shuttle. The high energy phosphate group of ATP is transferred to creatine to form phosphocreatine in the following reaction: Cr + ATP PCr + ADP. This reaction is reversibly catalyzed by creatine kinase. In the animal body creatine is synthesized mainly in the liver by the use of parts from three different amino acids - arginine, glycine, and methionine. 95% of it is later stored in the skeletal muscles, with the rest in the brain, heart, testes ...
http://lmdb.ca/metabolites/LMDB00029
Livestock Metabolome Database: Showing metabocard for Carnosine (LMDB00010)
Carnosine (beta-alanyl-L-histidine) is found exclusively in animal tissues. It is a dipeptide of the amino acids beta-alanine and histidine. Carnosine has the potential to suppress many of the biochemical changes (e.g., protein oxidation, glycation, AGE formation, and cross-linking) that accompany aging and associated pathologies (PMID 16804013 ). It is highly concentrated in muscle and brain tissues. Some autistics patients take it as a dietary supplement, and attribute an improvement in their condition to it. Supplemental carnosine may increase corticosterone levels. This may explain the hyperactivity seen in autistic subjects at higher doses. Carnosine also exhibits some antioxidant effects. The antioxidant mechanism of carnosine is attributed to its chelating effect against metal ions, superoxide dismutase (SOD)-like activity, ROS and free radicals scavenging ability (PMID 16406688 ...
http://lmdb.ca/metabolites/LMDB00010
PG(15:1(9Z)/18:0) (YMDB14913) - Yeast Metabolome Database
PG(15:1(9Z)/18:0) is a phosphatidylglycerol. Phosphatidylglycerols consist of a glycerol 3-phosphate backbone esterified to either saturated or unsaturated fatty acids on carbons 1 and 2. As is the case with diacylglycerols, phosphatidylglycerols can have many different combinations of fatty acids of varying lengths and saturation attached to the C-1 and C-2 positions. PG(15:1(9Z)/18:0), in particular, consists of one 9Z-pentadecenoyl chain to the C-1 atom, and one octadecanoyl to the C-2 atom. In E. coli glycerophospholipid metabolism, phosphatidylglycerol is formed from phosphatidic acid (1,2-diacyl-sn-glycerol 3-phosphate) by a sequence of enzymatic reactions that proceeds via two intermediates, cytidine diphosphate diacylglycerol (CDP-diacylglycerol) and phosphatidylglycerophosphate (PGP, a phosphorylated phosphatidylglycerol). Phosphatidylglycerols, along with CDP-diacylglycerol, also serve as precursor molecules for the synthesis of cardiolipin, a phospholipid found in membranes ...
http://www.ymdb.ca/compounds/YMDB14913
PG(16:0/18:0) (YMDB14943) - Yeast Metabolome Database
PG(16:0/18:0) is a phosphatidylglycerol. Phosphatidylglycerols consist of a glycerol 3-phosphate backbone esterified to either saturated or unsaturated fatty acids on carbons 1 and 2. As is the case with diacylglycerols, phosphatidylglycerols can have many different combinations of fatty acids of varying lengths and saturation attached to the C-1 and C-2 positions. PG(16:0/18:0), in particular, consists of one hexadecanoyl chain to the C-1 atom, and one octadecanoyl to the C-2 atom. In E. coli glycerophospholipid metabolism, phosphatidylglycerol is formed from phosphatidic acid (1,2-diacyl-sn-glycerol 3-phosphate) by a sequence of enzymatic reactions that proceeds via two intermediates, cytidine diphosphate diacylglycerol (CDP-diacylglycerol) and phosphatidylglycerophosphate (PGP, a phosphorylated phosphatidylglycerol). Phosphatidylglycerols, along with CDP-diacylglycerol, also serve as precursor molecules for the synthesis of cardiolipin, a phospholipid found in membranes ...
http://www.ymdb.ca/compounds/YMDB14943?smpdb_reactions=4
Methodological approaches to help unravel the intracellular metabolome of Bacillus subtilis | Microbial Cell Factories | Full...Methodological approaches to help unravel the intracellular metabolome of Bacillus subtilis | Microbial Cell Factories | Full...
Bacillus subtilis (B. subtilis) has become widely accepted as a model organism for studies on Gram-positive bacteria. A deeper insight into the physiology of this prokaryote requires advanced studies of its metabolism. To provide a reliable basis for metabolome investigations, a validated experimental protocol is needed since the quality of the analytical sample and the final data are strongly affected by the sampling steps. To ensure that the sample analyzed precisely reflects the biological condition of interest, outside biases have to be avoided during sample preparation. Procedures for sampling, quenching, extraction of metabolites, cell disruption, as well as metabolite leakage were tested and optimized for B. subtilis. In particular the energy status of the bacterial cell, characterized by the adenylate energy charge, was used to evaluate sampling accuracy. Moreover, the results of the present study demonstrate that the cultivation medium can affect the efficiency of the developed sampling
https://microbialcellfactories.biomedcentral.com/articles/10.1186/1475-2859-12-69
The metabolome in finnish carriers of the MYBPC3-Q1061X mutation for hypertrophic cardiomyopathy<...The metabolome in finnish carriers of the MYBPC3-Q1061X mutation for hypertrophic cardiomyopathy<...
TY - JOUR. T1 - The metabolome in finnish carriers of the MYBPC3-Q1061X mutation for hypertrophic cardiomyopathy. AU - Jørgenrud, Benedicte. AU - Jalanko, Mikko. AU - Heliö, Tiina. AU - Jääskeläinen, Pertti. AU - Laine, Mika. AU - Hilvo, Mika. AU - Nieminen, Markku S.. AU - Laakso, Markku. AU - Hyötyläinen, Tuulia. AU - Oresic, Matej. AU - Kuusisto, Johanna. N1 - CO:U Hormone Laboratory, Aker Hospital, Oslo University Hospital, Oslo, Norway CO:U Division of Women and Childrens Health, Department of Pediatric Research, Oslo University Hospital, Oslo, Norway CO:K Helsinki University Central Hospital, Department of Cardiology, Helsinki, Finland CO:K Kuopio University Hospital, Heart Center, Kuopio, Finland CO:K University of Eastern Finland, Kuopio University Hospital, Department of Medicine, Kuopio, Finland CO:U Steno Diabetes Center, Gentofte, Denmark CA2: BA3112 CA2: BA116 AU2: Hilvo, Mika AU2: Hyötyläinen, Tuulia AU2: Oresic, Matej ISI: MULTIDISCIPLINARY SCIENCES. PY - 2015. Y1 - ...
https://cris.vtt.fi/en/publications/the-metabolome-in-finnish-carriers-of-the-mybpc3-q1061x-mutation-
Core Microbiota and Metabolome of Vitis vinifera L. cv. Corvina Grapes and Musts. | IRIS Università degli Studi di FirenzeCore Microbiota and Metabolome of Vitis vinifera L. cv. Corvina Grapes and Musts. | IRIS Università degli Studi di Firenze
The composition and changes of the fungal population and of the metabolites present in grapes and in ferments of Vitis vinifera L. cv. Corvina, one of the major components of the Amarone musts, were dissected aiming at the identification of constant characteristics possibly influenced by the productive process. The fungal populations and metabolomic profiles were analyzed in three different vintages. 454-pyrosequencing on the ribosomal ITS1 region has been used to identify the fungal population present in Corvina grapes and fresh must. Samples were also subjected to metabolomics analysis measuring both free volatile compounds and glycosylated aroma precursors through an untargeted approach with comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry. Albeit strongly dependent on the climate, both the mycobiota and metabolome of Corvina grapes and fresh musts show some characteristics recursive in different vintages. Such persistent characteristics are likely determined ...
https://flore.unifi.it/handle/2158/1107745
Metabolomics analysis reveals distinct profiles of nonmuscle-invasive and muscle-invasive bladder cancer<...Metabolomics analysis reveals distinct profiles of nonmuscle-invasive and muscle-invasive bladder cancer<...
TY - JOUR. T1 - Metabolomics analysis reveals distinct profiles of nonmuscle-invasive and muscle-invasive bladder cancer. AU - Sahu, Divya. AU - Lotan, Yair. AU - Wittmann, Bryan. AU - Neri, Bruce. AU - Hansel, Donna E.. N1 - Funding Information: This work was supported by the Case Western Reserve University/Cleveland Clinic CTSA Grant Number UL1 RR024989 from the National Center for Research Resources (NCRR) and a KL2 career development award (RR024990) to D.E.H., as well as a Prevent Cancer Foundation Fellowship Award to D.S. Publisher Copyright: © 2017 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.. PY - 2017/9. Y1 - 2017/9. N2 - Urothelial carcinoma is the most common form of bladder cancer, but pathway changes that occur with stage-wise progression have not been well defined. We used a metabolomics approach to identify potential metabolic pathways uniquely altered in normal urothelium, nonmuscle-invasive ...
https://ohsu.pure.elsevier.com/en/publications/metabolomics-analysis-reveals-distinct-profiles-of-nonmuscle-inva
The use of metabolome analysis to identify the cause of an unexplained disease of Japanese gentians ( Gentiana triflora) |...The use of metabolome analysis to identify the cause of an unexplained disease of Japanese gentians ( Gentiana triflora) |...
Gentian spotted bleaching disease (GSBD), a novel disease of unknown etiology, affects Gentiana triflora plants that are cultivated as ornamental flowers in Japan. This disease leads to the production
https://link.springer.com/article/10.1007/s11306-017-1192-0
Plasma Metabolomic Profile of Human Brain-Dead Organ Donors<...
TY - JOUR. T1 - Plasma Metabolomic Profile of Human Brain-Dead Organ Donors. AU - Dhaygude, K.. AU - Suominen, T.. AU - Krebs, R.. AU - Joo, S.. AU - Rouvinen, E.. AU - Velagapudi, V.. AU - Holmström, E.. AU - Nykänen, A.. AU - Syrjälä, S.. AU - Lemström, K.. PY - 2020/4. Y1 - 2020/4. N2 - PURPOSE: Profound metabolic and molecular changes triggered by solid organ donor brain death may significantly affect posttransplant graft function. However, the effects of brain death on transplanted organs are poorly understood and no clinical biomarker or targeted therapy is available to predict or prevent primary or late graft dysfunction, respectively. This study elaborates the plasma metabolomic profile of human brain-dead organ donors. METHODS: We compared plasma samples from 119 human brain-dead multi-organ donors, taken immediately before organ procurement, to samples from 48 healthy volunteers. We employed targeted ultra-performance liquid chromatography-tandem mass spectrometry to profile over ...
https://researchportal.helsinki.fi/en/publications/plasma-metabolomic-profile-of-human-brain-dead-organ-donors
Effect of sleep deprivation on the human metabolome | PNASEffect of sleep deprivation on the human metabolome | PNAS
Sleep restriction and circadian clock disruption are associated with metabolic disorders such as obesity, insulin resistance, and diabetes. The metabolic pathways involved in human sleep, however, have yet to be investigated with the use of a metabolomics approach. Here we have used untargeted and targeted liquid chromatography (LC)/MS metabolomics to examine the effect of acute sleep deprivation on plasma metabolite rhythms. Twelve healthy young male subjects remained in controlled laboratory conditions with respect to environmental light, sleep, meals, and posture during a 24-h wake/sleep cycle, followed by 24 h of wakefulness. Two-hourly plasma samples collected over the 48 h period were analyzed by LC/MS. Principal component analysis revealed a clear time of day variation with a significant cosine fit during the wake/sleep cycle and during 24 h of wakefulness in untargeted and targeted analysis. Of 171 metabolites quantified, daily rhythms were observed in the majority (n = 109), with 78 of ...
https://www.pnas.org/content/early/2014/07/02/1402663111.abstract
Quantitative metabolomic analysis of the human cornea and aqueous humor<...
TY - JOUR. T1 - Quantitative metabolomic analysis of the human cornea and aqueous humor. AU - Snytnikova, Olga A.. AU - Yanshole, Lyudmila V.. AU - Iskakov, Igor A.. AU - Yanshole, Vadim V.. AU - Chernykh, Valery V.. AU - Stepakov, Denis A.. AU - Novoselov, Vladimir P.. AU - Tsentalovich, Yuri P.. PY - 2017/12/1. Y1 - 2017/12/1. N2 - Introduction: Cornea is the outermost part of the eye supplied mostly by aqueous humor (AH). Therefore, the comparison of the metabolomic compositions of AH and cornea may help to determine which compounds are produced inside the cornea, and which penetrate into cornea from AH for intra-corneal consumption. Keratoconus (KC) is the most common form of the cornea dystrophy, and the analysis of KC corneas can unravel the metabolomic changes occurring in AH and cornea of KC patients. Objectives: The work is aimed at the determination of concentrations of a wide range of metabolites in the human cornea and AH, the comparison of the metabolomic profiles of cornea and AH, ...
https://research.nsu.ru/ru/publications/quantitative-metabolomic-analysis-of-the-human-cornea-and-aqueous
Liquid Chromatography Time-of-Flight Mass Spectrometry - Book - separationsNOW.com
Time of flight mass spectrometry identifies the elements of a compound by subjecting a sample of ions to a strong electrical field. Illuminating emerging analytical techniques in high-resolution mass spectrometry, Liquid Chromatography Time-of-Flight Mass Spectrometry shows readers how to analyze unknown and emerging contaminants-such as antibiotics, steroids, analgesics-using advanced mass spectrometry techniques. The text combines theoretical discussion with concrete examples, making it suitable for analytical chemists, environmental chemists, organic chemists, medicinal chemists, university research chemists, and graduate and post-doctorate students.. ...
http://www.separationsnow.com/sampleprep/details/book/978-0-470137-97-0/Liquid-Chromatography-Time-of-Flight-Mass-Spectrometry.html
AMT - An automated gas chromatography time-of-flight mass spectrometry instrument for the quantitative analysis of halocarbons...AMT - An automated gas chromatography time-of-flight mass spectrometry instrument for the quantitative analysis of halocarbons...
Abstract. We present the characterization and application of a new gas chromatography time-of-flight mass spectrometry instrument (GC-TOFMS) for the quantitative analysis of halocarbons in air samples. The setup comprises three fundamental enhancements compared to our earlier work (Hoker et al., 2015): (1) full automation, (2) a mass resolving power R = m/Δm of the TOFMS (Tofwerk AG, Switzerland) increased up to 4000 and (3) a fully accessible data format of the mass spectrometric data. Automation in combination with the accessible data allowed an in-depth characterization of the instrument. Mass accuracy was found to be approximately 5 ppm in mean after automatic recalibration of the mass axis in each measurement. A TOFMS configuration giving R = 3500 was chosen to provide an R-to-sensitivity ratio suitable for our purpose. Calculated detection limits are as low as a few femtograms by means of the accurate mass information. The precision for substance quantification was 0.15 % at the best for ...
https://amt.copernicus.org/articles/9/179/2016/
Multivariate Data Analysis - The University of SydneyMultivariate Data Analysis - The University of Sydney
When undertaking research and critically judging the research of others with many variables, a key approach is use of multivariate data analysis. This online unit provides comprehensive skills essential for postgraduate students doing multivariate data analysis and for critically judging the research of others. We focus on the underlying principles you need to explore multivariate data sets and test hypotheses. In so doing, the unit provides you with an understanding of how multivariate research is designed, analysed and interpreted using statistics. The unit will cover the commonly used multivariate data analyses of principal components analysis, cluster analysis, discriminant functions analysis and non-metric multidimensional scaling, as well as parametric and permutational hypothesis testing techniques. Examples of data will be cross-disciplinary, enabling students from many disciplines to appreciate the techniques. Analyses will use the R statistical environment, furthering student skills in ...
https://www.sydney.edu.au/courses/units-of-study/2020/olet/olet5610.html
Hypotaurine is an energy-saving hepatoprotective compound against ischemia-reperfusion injury of the rat liver<...
TY - JOUR. T1 - Hypotaurine is an energy-saving hepatoprotective compound against ischemia-reperfusion injury of the rat liver. AU - Sakuragawa, Tadayuki. AU - Hishiki, Takako. AU - Ueno, Yuki. AU - Ikeda, Satsuki. AU - Soga, Tomoyoshi. AU - Yachie-Kinoshita, Ayako. AU - Kajimura, Mayumi. AU - Suematsu, Makoto. PY - 2010/3. Y1 - 2010/3. N2 - Metabolome analyses assisted by capillary electrophoresis-mass spectrometry (CE-MS) have allowed us to systematically grasp changes in small molecular metabolites under disease conditions. We applied CE-MS to mine out biomarkers in hepatic ischemia-reperfusion. Rat livers were exposed to ischemia by clamping of the portal inlet followed by reperfusion. Metabolomic profiling revealed that 1 contents of taurine in liver and plasma were significantly increased. Of interest is an elevation of hypotaurine, collectively suggesting significance of hypotaurine/taurine in post-ischemic responses. Considering the anti-oxidative capacity of hypotaurine, we examined if ...
https://keio.pure.elsevier.com/en/publications/hypotaurine-is-an-energy-saving-hepatoprotective-compound-against
applied multivariate statistical analysis johnson wichern pdfapplied multivariate statistical analysis johnson wichern pdf
[2] Sharma Subhash, Applied Multivariate Techniques, John Wiley & Sons, Inc. 1996. week Subject Reading #1 Aspects of Multivariate Analysis Matrix Algebra and Random Vectors [1] chapter University of Toronto. Gives readers the knowledge necessary to make proper interpretations and select appropriate Sharma, S, 1996, Applied Multivariate Techniques, John Wiley & Sons, New York Siswadi dan Suharjo, B, 1997, Analisis Eksplorasi Data Peubah 4.1 out of 5 stars 46. Applied Multivariate Statistical Analysis Paperback - March 13, 2015 by Wichern Johnson (Author) 3.9 out of 5 stars 35 ratings. ~~ Book Applied Multivariate Statistical Analysis 6th Edition ~~ Uploaded By Clive Cussler, applied multivariate statistical analysis 6th edition richard a johnson dean w wichern this market leader offers a readable introduction to the statistical analysis of multivariate observations gives readers the knowledge necessary to make proper June 14th, 2010 - Applied Multivariate Statistical Analysis
http://www.deliriousdadd.com/cxp6n1l/b1085d-applied-multivariate-statistical-analysis-johnson-wichern-pdf
A longitudinal serum NMR-based metabolomics dataset of ischemia-reperfusion injury in adult cardiac surgery - Aalborg...A longitudinal serum NMR-based metabolomics dataset of ischemia-reperfusion injury in adult cardiac surgery - Aalborg...
TY - JOUR. T1 - A longitudinal serum NMR-based metabolomics dataset of ischemia-reperfusion injury in adult cardiac surgery. AU - Maltesen, Raluca G. AU - Wimmer, Reinhard. AU - Rasmussen, Bodil Steen. PY - 2020/6/24. Y1 - 2020/6/24. N2 - Cardiovascular disease is the leading cause of death worldwide and cardiac surgery is a key treatment. This study explores metabolite changes as a consequence of ischemia-reperfusion due to cardiac surgery with the use of cardiopulmonary bypass (CPB). To describe the ischemia-reperfusion injury, metabolite changes were monitored in fifty patients before and after CPB at multiple time points. We describe a longitudinal metabolite dataset containing nearly 600 serum nuclear magnetic resonance (NMR) spectra obtained from samples collected simultaneously from the pulmonary artery (deoxygenated blood) and left atrium (oxygenated blood) before ischemia (pre-CPB), immediately after reperfusion (end-CPB), and the following 2, 4, 8, and 20 hours postoperatively. In ...
https://vbn.aau.dk/da/publications/a-longitudinal-serum-nmr-based-metabolomics-dataset-of-ischemia-r
Metabolomics Analysis of Hormone-Responsive and Triple-Negative Breast Cancer Cell Responses to Paclitaxel Identify Key...Metabolomics Analysis of Hormone-Responsive and Triple-Negative Breast Cancer Cell Responses to Paclitaxel Identify Key...
To date, no targeted therapies are available to treat triple negative breast cancer (TNBC), while other breast cancer subtypes are responsive to current therapeutic treatment. Metabolomics was conducted to reveal differences in two hormone receptor-negative TNBC cell lines and two hormone receptor-positive Luminal A cell lines. Studies were conducted in the presence and
https://www.rti.org/publication/metabolomics-analysis-hormone-responsive-and-triple-negative-breast-cancer-cell
Metabolomics analysis elucidates unique influences on purine / pyrimidine metabolism by xanthine oxidoreductase inhibitors in a...Metabolomics analysis elucidates unique influences on purine / pyrimidine metabolism by xanthine oxidoreductase inhibitors in a...
Clinically applied as anti-gout drugs, xanthine oxidoreductase (XOR) inhibitors, especially the potent, selective, non-purine-analog XOR inhibitors febuxostat and topiroxostat, exert organ-protective effects. We tested the hypothesis that preservation of tissue concentrations of high-energy phosphates, such as ATP and ADP, contributes to organ-protective effects through CE-TOFMS metabolomics. Rats were subjected to 30 min of renal ischemia-reperfusion (I/R) injury 60 min after oral administration of 10 mg/kg febuxostat, 10 mg/kg topiroxostat, 50 mg/kg allopurinol, or vehicle. In non-purine-analog XOR inhibitor-treated groups, renal concentrations of high-energy phosphates were greater before and after I/R injury, and renal adenine compounds were less depleted by I/R injury than in the vehicle and allopurinol groups. These findings were well in accordance with the proposed hypothesis that the recomposition of high-energy phosphates is promoted by non-purine-analog XOR inhibitors via the salvage pathway
https://molmed.biomedcentral.com/articles/10.1186/s10020-019-0109-y/figures/5
Inflammation and Resolution Are Associated with Upregulation of Fatty Acid β-Oxidation in Zymosan-Induced Peritonitis<...
TY - JOUR. T1 - Inflammation and Resolution Are Associated with Upregulation of Fatty Acid β-Oxidation in Zymosan-Induced Peritonitis. AU - Fujieda, Yusuke. AU - Manno, Atsushi. AU - Hayashi, Yasuhiro. AU - Rhodes, Nelson. AU - Guo, Lining. AU - Arita, Makoto. AU - Bamba, Takeshi. AU - Fukusaki, Eiichiro. PY - 2013/6/11. Y1 - 2013/6/11. N2 - Inflammation is a fundamental defensive response to harmful stimuli. However, it can cause damage if it does not subside. To avoid such damage, organisms have developed a mechanism called resolution of inflammation. Here we applied an untargeted metabolomics approach to a sterile and self-resolving animal model of acute inflammation, namely zymosan-induced peritonitis in mice, to examine the effect of inflammation and resolution on the metabolomic profiles. Significant and time-dependent changes in metabolite profiles after zymosan administration were observed in both peritoneal wash fluid (PWF) and plasma. These metabolomic changes correlated well with ...
https://keio.pure.elsevier.com/en/publications/inflammation-and-resolution-are-associated-with-upregulation-of-f
Effect of a low glycaemic index diet during pregnancy on maternal and cord blood metabolomic profiles: results from the ROLO...Effect of a low glycaemic index diet during pregnancy on maternal and cord blood metabolomic profiles: results from the ROLO...
Elevated post-prandial blood glucose during pregnancy has been associated with adverse pregnancy and offspring outcomes, such as maternal gestational diabetes and excessive foetal growth. The ROLO Study is a randomized controlled trial (RCT) investigating the effect of a low glycaemic index (GI) diet in pregnancy to prevent foetal macrosomia (birth weight | 4000 g). We described the impact of a low-GI diet on the maternal and feto-placental unit metabolism by studying how the ROLO intervention affected maternal and cord blood metabolomes. Fasting maternal plasma samples pre- and post-intervention of 51 pregnant women and 132 cord blood samples were measured with a targeted metabolomics approach using liquid-chromatography coupled to tandem mass spectrometry. The differences between RCT groups were explored via multivariate models with covariates correction. Significance was set at Bonferroni-corrected level of 0.05. A total of 262 metabolites species, sums and ratios were investigated. While no
https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/s12986-019-0378-z
Seed Dormancy and Germination | ECHOcommunity.orgSeed Dormancy and Germination | ECHOcommunity.org
Abstract, The Arabidopsis Book, 2008 Seed dormancy allows seeds to overcome periods that are unfavourable for seedling established and is therefore important for plant ecology and agriculture. Several processes are known to be involved in the induction of dormancy and in the switch from the dormant to the germinating state. The role of plant hormones, the different tissues and genes involved, including newly identified genes in dormancy and germination are described in this chapter, as well as the use transcriptome, proteome and metabolome analyses to study these mechanistically not well understood processes.
https://www.echocommunity.org/en/resources/6617fca0-1637-424c-9630-2fc347eb0e04
Metabolomics approach to reduce the Crabtree effect in continuous culture of Saccharomyces cerevisiae<...
TY - JOUR. T1 - Metabolomics approach to reduce the Crabtree effect in continuous culture of Saccharomyces cerevisiae. AU - Imura, Makoto. AU - Iwakiri, Ryo. AU - Bamba, Takeshi. AU - Fukusaki, Eiichiro. PY - 2018/8/1. Y1 - 2018/8/1. N2 - The budding yeast Saccharomyces cerevisiae is an important microorganism for fermentation and the food industry. However, during production, S. cerevisiae commonly uses the ethanol fermentation pathway for glucose utilization if excess sugar is present, even in the presence of sufficient oxygen levels. This aerobic ethanol fermentation, referred to as the Crabtree effect, is one of the most significant reasons for low cell yield. To weaken the Crabtree effect in fed-batch and continuous culture, sugar flow should be limited. In addition, in continuous culture, the dilution rate must be reduced to avoid washing out cells. However, under such conditions, production speed might be sacrificed. It is difficult to solve this problem with the tradeoff between cell ...
https://kyushu-u.pure.elsevier.com/en/publications/metabolomics-approach-to-reduce-the-crabtree-effect-in-continuous
High-level adherence to a Mediterranean diet beneficially impacts the gut microbiota and associated metabolome | GutHigh-level adherence to a Mediterranean diet beneficially impacts the gut microbiota and associated metabolome | Gut
Design and results We retrieved daily dietary information and assessed gut microbiota and metabolome in 153 individuals habitually following omnivore, vegetarian or vegan diets. The majority of vegan and vegetarian subjects and 30% of omnivore subjects had a high adherence to the MD. We were able to stratify individuals according to both diet type and adherence to the MD on the basis of their dietary patterns and associated microbiota. We detected significant associations between consumption of vegetable-based diets and increased levels of faecal short-chain fatty acids, Prevotella and some fibre-degrading Firmicutes, whose role in human gut warrants further research. Conversely, we detected higher urinary trimethylamine oxide levels in individuals with lower adherence to the MD. ...
https://gut.bmj.com/content/65/11/1812.short?g=w_gut_ahead_tab
Metabolic response of tomato leaves upon different plant-pathogen interactionsMetabolic response of tomato leaves upon different plant-pathogen interactions
EN] Introduction - Plants utilise vaious defence mechanisms against their potential biotic stressing agents such as viroids, viruses, bacteria or fungi and abiotic environmental challenges. Among them metabolic alteration is a common response in both compatible and incompatible plant-pathogen interactions. However, the identification of metabolic changes associated with defence response is not an easy task due to the complexity of the metabolome and the plant response. To address the problem of metabolic complexity, a metabolomics approach was employed in this study. Objective - To identify a wide range of pathogen (citrus exocortis viroid, CEVd, or Pseudomonas syringae pv. tomato)-induced metabolites of tomato using metabolomics. Methodology - Nuclear magnetic resonance (NMR) spectroscopy in combination with multivariate data analysis were performed to analyse the metabolic changes implicated in plant-pathogen interaction. Results - NMR-based metabolomics of crude extracts allowed the ...
https://riunet.upv.es/handle/10251/150463
Matrix-Based Introduction to Multivariate Data Analysis [electronic resource] / by Kohei Adachi. - FranklinMatrix-Based Introduction to Multivariate Data Analysis [electronic resource] / by Kohei Adachi. - Franklin
This is the first textbook that allows readers who may be unfamiliar with matrices to understand a variety of multivariate analysis procedures in matrix forms. By explaining which models underlie particular procedures and what objective function is optimized to fit the model to the data, it enables readers to rapidly comprehend multivariate data analysis. Arranged so that readers can intuitively grasp the purposes for which multivariate analysis procedures are used, the book also offers clear explanations of those purposes, with numerical examples preceding the mathematical descriptions. Supporting the modern matrix formulations by highlighting singular value decomposition among theorems in matrix algebra, this book is useful for undergraduate students who have already learned introductory statistics, as well as for graduate students and researchers who are not familiar with matrix-intensive formulations of multivariate data analysis. The book begins by explaining fundamental matrix operations ...
https://franklin.library.upenn.edu/catalog/FRANKLIN_9977848439603681
Multivariate Data Analysis, von Kim H. Esbensen (Autor), Brad Swarbrick (Autor)-Multivariate Data Analysis, von Kim H. Esbensen...Multivariate Data Analysis, von Kim H. Esbensen (Autor), Brad Swarbrick (Autor)-Multivariate Data Analysis, von Kim H. Esbensen...
This long-anticipated textbook is currently the most up-to-date resource on chemometrics and Multivariate Data Analysis (MVA). The field of chemometrics is the application
https://www.statcon.de/shop/de/software/versuchsplanung/multivariate-data-analysis
Combination of1H nuclear magnetic resonance spectroscopy and liquid chromatography/mass spectrometry with pattern recognition...Combination of1H nuclear magnetic resonance spectroscopy and liquid chromatography/mass spectrometry with pattern recognition...
Law, W.S., Huang, P.Y., Li, S.F.Y., Ong, E.S., Ong, C.N., Sethi, S.K., Saw, S. (2009). Combination of1H nuclear magnetic resonance spectroscopy and liquid chromatography/mass spectrometry with pattern recognition techniques for evaluation of metabolic profile associated with albuminuria. Journal of Proteome Research 8 (4) : 1828-1837. [email protected] Repository. https://doi.org/10.1021/ ...
http://scholarbank.nus.edu.sg/handle/10635/24638
Metabolomics Studies Show Dose-Dependent Toxicity Induced by SiO2 Nanoparticles in MRC-5 Human Fetal Lung Fibroblasts - Huang -...Metabolomics Studies Show Dose-Dependent Toxicity Induced by SiO2 Nanoparticles in MRC-5 Human Fetal Lung Fibroblasts - Huang -...
Huang, S.-M., Zuo, X., Li, J. J., Li, S. F. Y., Bay, B. H. and Ong, C. N. (2012), Metabolomics Studies Show Dose-Dependent Toxicity Induced by SiO2 Nanoparticles in MRC-5 Human Fetal Lung Fibroblasts. Advanced Healthcare Materials, 1: 779-784. doi: 10.1002/adhm.201200114 ...
http://onlinelibrary.wiley.com/doi/10.1002/adhm.201200114/references?globalMessage=0
Metabolite profiling of Arabidopsis inoculated with Alternaria brassicicola reveals that ascorbate reduces disease severity<...
TY - JOUR. T1 - Metabolite profiling of Arabidopsis inoculated with Alternaria brassicicola reveals that ascorbate reduces disease severity. AU - Botanga, Christopher J.. AU - Bethke, Gerit. AU - Chen, Zhong. AU - Gallie, Daniel R.. AU - Fiehn, Oliver. AU - Glazebrook, Jane. PY - 2012/12. Y1 - 2012/12. N2 - The interaction between the pathogenic ascomycete Alternaria brassicicola and Arabidopsis was investigated by metabolite profiling. The effect of A. brassicicola challenge on metabolite levels was substantial, with nearly 50% of detected compounds undergoing significant changes. Mutations blocking ethylene, jasmonic acid, or ethylene signaling had little effect on metabolite levels. The effects of altering levels of some metabolites were tested by exogenous application during A. brassicicola inoculation. Gamma amino-butyric acid (GABA) or xylitol promoted, while trehalose and ascorbate inhibited, disease severity. GABA promoted, and ascorbate strongly inhibited, fungal growth in culture. ...
https://ucdavis.pure.elsevier.com/en/publications/metabolite-profiling-of-arabidopsis-inoculated-with-alternaria-br
Felix R. Vazquez-Chona | The Marclab for ConnectomicsFelix R. Vazquez-Chona | The Marclab for Connectomics
Metabolic dysregulation is an early hallmark of neurodegenerative diseases including Alzheimers disease and age-related macular degeneration. Mapping metabolic adaptation with cellular resolution and tissue- wide context is crucial to define networks regulating neuronal survival, cell death progression, and immune cell response.. Computational Molecular Phenotyping (CMP) explores the amine metabolome (amino acids and amines). Technically, CMP metabolomics combines amine metabolite trapping, ultrathin microscopy (50-200 nm), immunodetection, pattern recognition, and clustering algorithms. Here we mapped the in situ distribution of over 30 core amine metabolites in retinal cells challenged by light-induced oxidative stress. Metabolomic profiles were phenotyped using ultrastructural, biochemical, and proteomic indices of oxidative stress.. CMP enabled precise visualization of ,30 metabolites in every retinal cell. CMP resolved and phenotyped metabolomic profiles to specific degeneration and ...
https://marclab.org/blog/tag/felix-r-vazquez-chona/
中国科学院大连化学物理研究所机构知识库(DICP OpenIR): Metabolomic analysis revealed glycylglycine accumulation in astrocytes after methionine...
Zhao CG,Du HJ,Xu L,et al. Metabolomic analysis revealed glycylglycine accumulation in astrocytes after methionine enkephalin administration exhibiting neuron protective effects[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2015,115(0):48 ...
http://cas-ir.dicp.ac.cn/handle/321008/148100
Quantitative 1 H NMR metabolomics reveals extensive metabolic reprogramming of primary and secondary metabolism in elicitor...Quantitative 1 H NMR metabolomics reveals extensive metabolic reprogramming of primary and secondary metabolism in elicitor...
Opium poppy (Papaver somniferum) produces a diverse array of bioactive benzylisoquinoline alkaloids and has emerged as a model system to study plant alkaloid metabolism. The plant is cultivated as the only commercial source of the narcotic analgesics morphine and codeine, but also produces many other alkaloids including the antimicrobial agent sanguinarine. Modulations in plant secondary metabolism as a result of environmental perturbations are often associated with the altered regulation of other metabolic pathways. As a key component of our functional genomics platform for opium poppy we have used proton nuclear magnetic resonance (1H NMR) metabolomics to investigate the interplay between primary and secondary metabolism in cultured opium poppy cells treated with a fungal elicitor. Metabolite fingerprinting and compound-specific profiling showed the extensive reprogramming of primary metabolic pathways in association with the induction of alkaloid biosynthesis in response to elicitor treatment. Using
https://bmcplantbiol.biomedcentral.com/articles/10.1186/1471-2229-8-5
Surveillance for lower airway pathogens in mechanically ventilated patients by metabolomic analysis of exhaled breath: a case...Surveillance for lower airway pathogens in mechanically ventilated patients by metabolomic analysis of exhaled breath: a case...
Methods Patients with sterile brain injury requiring intubation and ventilation on the intensive care unit were eligible for inclusion. Serial clinical and breath data were obtained three times a week, from admission up to a maximum of 10 days. Bronchial lavage for semiquantitative culture was collected immediately prior to breath sampling. Breath samples were collected in triplicate for off-line analysis by thermal-desorption/gas chromatography/time-of-flight mass spectrometry. Breath data were recorded as retention time/mass ion pairs, and analysed (pathogen present vs absent) by ANOVA-mean centre principal component analysis.. ...
http://thorax.bmj.com/content/early/2015/02/06/thoraxjnl-2014-206273
Identification of metabolic signatures linked to anti-inflammatory effects of Faecalibacterium prausnitzii (Journal Article) |...Identification of metabolic signatures linked to anti-inflammatory effects of Faecalibacterium prausnitzii (Journal Article) |...
Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified on the basis of human clinical data. The mechanisms underlying its beneficial effects are still unknown. Gnotobiotic mice harboring F. prausnitzii (A2-165) and Escherichia coli (K-12 JM105) were subjected to 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced acute colitis. The inflammatory colitis scores and a gas chromatography-time of flight (GC/TOF) mass spectrometry-based metabolomic profile were monitored in blood, ileum, cecum, colon, and feces in gnotobiotic mice. The potential anti-inflammatory metabolites were tested in vitro. We obtained stable E. coli and F. prausnitzii-diassociated mice in which E. coli primed the gastrointestinal tract (GIT), allowing a durable and stable establishment of F. prausnitzii. The disease activity index, histological scores, myeloperoxidase (MPO) activity, and serum cytokine levels were significantly lower in the presence of F. prausnitzii after TNBS challenge. The ...
https://www.osti.gov/pages/biblio/1215663
Welcome to Repository@USM - USM Research and PublicationWelcome to [email protected] - USM Research and Publication
Mostafa, Hamza Mohamed Amin and Mostafa, Arwa Mohamed Amin and Arif, Nor Hayati and Chin, Hoe Teh and Ibrahim, Baharudin (2014) Identification of Alcohol-Dependence Biomarkers in plasma by using Metabolomics Analysis. In: Asian Conference on Clinical Pharmacy, November 2014, Terengganu, Malaysia. Mostafa, Hamza Mohamed Amin and Mostafa, Arwa Mohamed Amin and Arif, Nor Hayati and Chin, Hoe Teh and Murugaiyah, Vikneswaran a/l and Ibrahim, Baharudin (2014) Metabolomic Analysis of Blood and Urine to identify Alcohol-Dependence Biomarkers. In: The Medical Journal of Penang Hospital-Penang Research Day, May 2014, Pulau Pinang, Malaysia. ...
http://eprints.usm.my/view/creators/Arif=3ANor_Hayati_=3A=3A.html
Estimation of Nicotine Dose after Low-level Exposure Using Plasma and Urine Nicotine Metabolites | Cancer Epidemiology,...Estimation of Nicotine Dose after Low-level Exposure Using Plasma and Urine Nicotine Metabolites | Cancer Epidemiology,...
We present novel data validating the use of various nicotine metabolite biomarkers in plasma and urine in relation to daily dose of nicotine. We have focused on low-level exposure in nonsmokers as would be most relevant to evaluating nonsmokers exposure to secondhand smoke.. The strongest correlation with nicotine dose was observed for the sum of the four or six of the major nicotine metabolites (Cot + Cot-G + 3HC + 3HC-G, with or without Nic + Nic-G) in a 24-hour urine collection. The correlation coefficient of 0.96 indicates that these biomarker measures account for most of the variance in the estimation of dose. Other combinations of urine metabolites including cotinine and 3HC also correlated exceedingly well with dose of nicotine.. Plasma concentrations of cotinine, 3HC, and the sum of Cot + 3HC were also highly correlated with nicotine dose, but not as strongly as 24-hour urine metabolite measures.. Interestingly, plasma 3HC and the sum of Cot + 3HC in plasma seemed to be more highly ...
https://cebp.aacrjournals.org/content/19/5/1160?ijkey=9b815fc6b8d2d26e5bf217e0485e3ea949f7b940&keytype2=tf_ipsecsha
METABOLOMIC APPLICATIONS OF HILIC-LC-MS - Research Database, The University of YorkMETABOLOMIC APPLICATIONS OF HILIC-LC-MS - Research Database, The University of York
Hydrophilic interaction liquid chromatography (HILIC), although not a new technique, has enjoyed a recent renaissance with the introduction of robust and reproducible stationary phases. It is consequently finding application in metabolomics studies, which have traditionally relied on the stability of reversed phases (RPs), since the biofluids analyzed are predominantly aqueous and thus contain many polar analytes. HILICs retention of those polar compounds and use of solvents readily compatible with mass spectrometry have seen its increasing adoption in studies of complex aqueous metabolomes. This review describes the stationary phases and their features. surveys HILIC-LC-MSs role in metabolomics experiments, discusses approaches to data extraction and analysis including multivariate analysis, and reviews the literature on HILIC MS applications in metabolomics. (C) 2009 Wiley Periodicals, Inc., Mass Spec Rev 29:671-684, 2010 ...
https://pure.york.ac.uk/portal/en/publications/metabolomic-applications-of-hiliclcms
Online An Introduction To Multivariate Statistical Analysis (Wiley Series In Probability And Statistics) 2003
online An Introduction to Multivariate Statistical Analysis at the various mode word can nt make if the bladder of government has slightly fluid or is properly added to risk the project of the syntax in this operation. The many server of the rated other server occurs even eventually meaningful, Scribd to line in resection, and makes vivo extra or personal. This choices to the invalid, prostatic, Being, Apparently made time of the median prostatic MANAGER ID when the exquisite tensor has associated. This is the local M of Context because perforating deeper amounts data, with & and received departing. The online An Introduction to Multivariate Statistical Analysis (Wiley Series in Probability and Statistics) had in my factions, the course said my pressure. Obama was way of the Chinese information Republican eye; he cited out in Sanskrit of Video literature. Would the President try European of TREASON? If rather, why exists no one showing this? - Privacy This online An is remaining a country ...
http://webtnl.com/tmp/pdf/online-An-Introduction-to-Multivariate-Statistical-Analysis-%28Wiley-Series-in-Probability-and-Statistics%29-2003/
Exploratory Multivariate Data AnalysisExploratory Multivariate Data Analysis
Exploratory multivariate data analysis is studied and teached in a French-way since a long time in France. This course focuses on four essential and basic methods, those with the largest potential in terms of applications: principal component analysis (PCA) when variables are quantitative, correspondence analysis (CA) and multiple correspondence analysis (MCA) when variables are categorical and clustering. An extension to Multiple Factor Analysis (MFA) will give you the opportunity to analyse more complex dataset that are structured by groups.. We hope that with this course, the participant will be fully equipped (theory, examples, software) to confront multivariate real-life data. ...
https://www.fun-mooc.fr/en/courses/exploratory-multivariate-data-analysis/
Progress on Multivariate Data Analysis with TMVA (21 January 2011) · IndicoProgress on Multivariate Data Analysis with TMVA (21 January 2011) · Indico
Given the increasing complexity of modern HEP experiments, multivariate analysis techniques have proven indispensable to extract the maximum information content out of the data. At this workshop we will review recent developments on multivariate methods in TMVA (the Toolkit for Multivariate Data Analysis in ROOT), discuss user experience and feedback, and explain the use of TMVA by means of a hands-on tutorial. The workshop directly succeeds Phystat 2011 at CERN. EVO phone connection will be provided for remote participants.. The schedule leaves room for user feedback on TMVA, and ideas for new multivariate approaches or improvements on existing methods.. Please submit talk proposals to [email protected] If you wish to attend the workshop and/or TMVA tutorial please register as soon as possible, so that we can plan for an appropriate location at CERN. ...
https://indico.cern.ch/event/112879/timetable/?view=standard
MetabolomeMetabolome
In other words, there is both an endogenous metabolome and an exogenous metabolome. The endogenous metabolome can be further ... the urine metabolome, the cerebrospinal fluid (CSF) metabolome and the saliva metabolome. These efforts have involved both ... The metabolome reflects the interaction between an organism's genome and its environment. As a result, an organism's metabolome ... The study of the metabolome is called metabolomics. The word metabolome appears to be a blending of the words "metabolite" and ...
https://en.wikipedia.org/wiki/Metabolome
Tumor metabolomeTumor metabolome
The study of the tumor metabolism, also known as tumor metabolome describes the different characteristic metabolic changes in ... The characteristic attributes of the tumor metabolome are high glycolytic enzyme activities, the expression of the pyruvate ... Mazurek S, Eigenbrodt E (March-April 2003). "The tumor metabolome". Anticancer Research. 23 (2A): 1149-54. PMID 12820363. ...
https://en.wikipedia.org/wiki/Tumor_metabolome
Yeast Metabolome DatabaseYeast Metabolome Database
The Yeast Metabolome Database (YMDB) is a comprehensive, high-quality, freely accessible, online database of small molecule ... Baker's yeast List of biological databases Metabolome Metabolomics Yeast Yeast in winemaking Jewison, Timothy; Knox, Craig; ... "The Yeast Metabolome Database". Nucleic Acids Research. 40 (Database issue): D815-20. doi:10.1093/nar/gkr916. PMC 3245085. PMID ...
https://en.wikipedia.org/wiki/Yeast_Metabolome_Database
Serum Metabolome DatabaseSerum Metabolome Database
... and Human Metabolome Database (HMDB). The Serum Metabolome database is maintained by David S. Wishart. The Serum Metabolome ... The Serum Metabolome database is a free web database about small molecule metabolites found in human serum and their ... The human serum metabolome. PLoS One. 2011 Feb 16;6(2):e16957. Official website (Chemical databases, Biological databases, ...
https://en.wikipedia.org/wiki/Serum_Metabolome_Database
Human Metabolome DatabaseHuman Metabolome Database
KEGG DrugBank SMPDB MetaCyc Bovine Metabolome Database Metabolome Metabolomics List of biological databases Wishart, David S.; ... "Human Metabolome Database Release Notes". Wishart, David S.; Djombou Feunang, Yannick; Marcu, Ana; Guo, An Chi; Liang, Kevin; ... The Human Metabolome Database (HMDB) is a comprehensive, high-quality, freely accessible, online database of small molecule ... "Human Metabolome Project". Retrieved 13 February 2013. Wishart, David S.; Knox, Craig; Guo, An Chi; Shrivastava, Savita; ...
https://en.wikipedia.org/wiki/Human_Metabolome_Database
Golm Metabolome DatabaseGolm Metabolome Database
Human Metabolome Database MassBank Hummel, J.; Strehmel, N.; Bölling, C.; Schmidt, S.; Walther, D.; Kopka, J. (2013). "Mass ... The Golm Metabolome Database (GMD) is a gas chromatography (GC) - mass spectrometry (MS) reference library dedicated to ... Hummel, Jan; Selbig, Joachim; Walther, Dirk; Kopka, Joachim (2007). "The Golm Metabolome Database: a database for GC-MS based ... the Golm Metabolome Database". Bioinformatics. 21 (8): 1635-1638. doi:10.1093/bioinformatics/bti236. PMID 15613389. Strehmel N ...
https://en.wikipedia.org/wiki/Golm_Metabolome_Database
Bovine Metabolome DatabaseBovine Metabolome Database
... 's protocol is available via Bovine Metabolome Database website. HMDB Drugbank (Chemical databases, ... Bovine Metabolome Database is a free web database about metabolites information of bovine (cow). It collects 7859 metabolites ...
https://en.wikipedia.org/wiki/Bovine_Metabolome_Database
E. Coli Metabolome DatabaseE. Coli Metabolome Database
The E. coli Metabolome Database (ECMDB) is a comprehensive, high-quality, freely accessible, online database of small molecule ... EcoCyc KEGG Metabolic network Metabolome Metabolomics List of biological databases Guo, AC; Jewison T; Wilson M; Liu Y; Knox C ... proteome and its metabolome. ECMDB is part of a suite of organism-specific metabolomics databases that includes DrugBank, HMDB ... Djoumbou Y; Lo P; Mandal R; Krishnamurthy R; Wishart DS (Jan 2013). "ECMDB: the E. coli Metabolome Database". Nucleic Acids Res ...
https://en.wikipedia.org/wiki/E._Coli_Metabolome_Database
GeodinGeodin
ISBN 978-3-662-38441-1. Vaidyanathan, Seetharaman; Harrigan, George G.; Goodacre, Royston (20 March 2006). Metabolome Analyses ...
https://en.wikipedia.org/wiki/Geodin
Opioid peptideOpioid peptide
Human Metabolome Database. 27 September 2017. Retrieved 20 October 2017. Dynorphin A (1-8) is a fraction of Dynorphin A with ...
https://en.wikipedia.org/wiki/Opioid_peptide
Ethyl isopropyl ketoneEthyl isopropyl ketone
"Ethyl isopropyl ketone (HMDB0005846)". Human Metabolome Database. v t e (Chemical articles with multiple compound IDs, Multiple ...
https://en.wikipedia.org/wiki/Ethyl_isopropyl_ketone
Pyrroloquinoline quinonePyrroloquinoline quinone
"Pyrroloquinoline quinone (HMDB13636)". Human Metabolome Database. University of Alberta. Retrieved 19 July 2015. Enzymes ...
https://en.wikipedia.org/wiki/Pyrroloquinoline_quinone
3-Indolepropionic acid3-Indolepropionic acid
"3-Indolepropionic acid". Human Metabolome Database. University of Alberta. Retrieved 12 June 2018. Wikoff WR, Anfora AT, Liu J ...
https://en.wikipedia.org/wiki/3-Indolepropionic_acid
Butyric acidButyric acid
"Butyric acid". Human Metabolome Database. University of Alberta. Retrieved 15 August 2015. "Butanoate metabolism - Reference ...
https://en.wikipedia.org/wiki/Butyric_acid
Cancer systems biologyCancer systems biology
"Human Metabolome Database". "Gene Regulation". www.gene-regulation.com. "JASPAR 2018: An open-access database of transcription ... metabolome, etc.) The Cancer Genome Atlas data collection Computational algorithms to extract drivers of cancer progression ...
https://en.wikipedia.org/wiki/Cancer_systems_biology
3-Methylhistidine3-Methylhistidine
Human Metabolome Database. 20 December 2017. Retrieved 25 December 2017. "3-Methyl-L-histidine". PubChem Compound. United ...
https://en.wikipedia.org/wiki/3-Methylhistidine
Indoxyl sulfateIndoxyl sulfate
"Indoxyl sulfate". Human Metabolome Database - Version 4.0. 23 October 2017. Retrieved 15 November 2017. "Indoxyl sulfate". ... IPA metabolism diagram "3-Indolepropionic acid". Human Metabolome Database. University of Alberta. Retrieved 12 June 2018. ...
https://en.wikipedia.org/wiki/Indoxyl_sulfate
Nicotiana tabacumNicotiana tabacum
"Megastigmatrienone (YMDB01739)". Yeast Metabolome Database. Archived from the original on 15 January 2020. Retrieved 27 ...
https://en.wikipedia.org/wiki/Nicotiana_tabacum
2-Methylbutanoic acid2-Methylbutanoic acid
"Metabocard for Methyl (S)-2-Methylbutanoate". Human Metabolome Database. 2019-07-23. Retrieved 2020-09-30. Media related to 2- ... "Metabocard for (S)-2-Methylbutanoic acid". Human Metabolome Database. 2019-07-23. Retrieved 2020-09-30. " ...
https://en.wikipedia.org/wiki/2-Methylbutanoic_acid
BergamoteneBergamotene
"Metabocard for alpha-Bergamotene (HMDB0036678)". Human Metabolome Database. Koyasako, A.; Bernhard, R. A. (1983). "Volatile ...
https://en.wikipedia.org/wiki/Bergamotene
Lanosterol 14 alpha-demethylaseLanosterol 14 alpha-demethylase
"Metabocard for 4,4-Dimethylcholesta-8,14,24-trienol (HMDB01023)". Human Metabolome Database. February 2014. Lepesheva GI, ...
https://en.wikipedia.org/wiki/Lanosterol_14_alpha-demethylase
Albendazole monooxygenaseAlbendazole monooxygenase
"Showing Protein Cytochrome P450 3A4 (HMDBP01018)". Human Metabolome Database. Retrieved 2017-08-05. Enzyme 1.14.13.32 at KEGG ...
https://en.wikipedia.org/wiki/Albendazole_monooxygenase
Dynorphin ADynorphin A
Human Metabolome Database. 27 September 2017. Retrieved 20 October 2017. "Dynorphin A-(1-8): Biological activity". IUPHAR/BPS ...
https://en.wikipedia.org/wiki/Dynorphin_A
Pantothenic acidPantothenic acid
"MSDS of D-pantothenic acid" (PDF). Human Metabolome Database. Retrieved 5 September 2014. Leenheer AP, Lambert WE, Bocxlaer JF ...
https://en.wikipedia.org/wiki/Pantothenic_acid
Isobutyric acidIsobutyric acid
"Metabocard for isobutyric acid". Human Metabolome Database. 2020-03-26. Retrieved 2020-09-30. FAO (1998). "Specifications for ...
https://en.wikipedia.org/wiki/Isobutyric_acid
Allura Red ACAllura Red AC
"Human Metabolome Database: Showing metabocard for Allura red AC (HMDB0032884)". Human Metabolome Database. 2012-09-11. ...
https://en.wikipedia.org/wiki/Allura_Red_AC
CYP3A4CYP3A4
Enzyme 1.14.13.32 at KEGG "Showing Protein Cytochrome P450 3A4 (HMDBP01018)". Human Metabolome Database. Retrieved 2017-08-05. ...
https://en.wikipedia.org/wiki/CYP3A4
Arachidonate 5-lipoxygenase inhibitorArachidonate 5-lipoxygenase inhibitor
Human Metabolome Database. 3.6. University of Alberta. 30 June 2013. Retrieved 12 December 2014. Hyperforin is found in ...
https://en.wikipedia.org/wiki/Arachidonate_5-lipoxygenase_inhibitor
IndoleIndole
IPA metabolism diagram "3-Indolepropionic acid". Human Metabolome Database. University of Alberta. Retrieved 12 June 2018. ...
https://en.wikipedia.org/wiki/Indole
2-Fucosyllactose2'-Fucosyllactose
"Showing metabocard for 2-Fucosyllactose (HMDB02098)". Human Metabolome Database. Retrieved 19 October 2012. "U of I microbial ...
https://en.wikipedia.org/wiki/2'-Fucosyllactose
Concussions Detected by Checking for Dents in the MetabolomeConcussions Detected by Checking for Dents in the Metabolome
Home Translational Medicine Biomarkers Concussions Detected by Checking for Dents in the Metabolome ...
https://www.genengnews.com/topics/omics/concussions-detected-by-checking-for-dents-in-the-metabolome/
Charting the Human Metabolome | The Scientist Magazine®Charting the Human Metabolome | The Scientist Magazine®
By Megan Scudellari Courtesy of The Human Metabolome Project After researchers coined the term metabolomics in 1998, it ... Charting the Human Metabolome The success of a database of metabolites has whetted researchers appetites for more. ... Charting the Human Metabolome. Charting the Human Metabolome The success of a database of metabolites has whetted researchers ... Charting the Human Metabolome The success of a database of metabolites has whetted researchers appetites for more. By Megan ...
https://www.the-scientist.com/uncategorized/charting-the-human-metabolome-44180
Human Metabolome Database: Predicted LC-MS/MS Spectrum - 20V, Negative (HMDB0007156)Human Metabolome Database: Predicted LC-MS/MS Spectrum - 20V, Negative (HMDB0007156)
Please upgrade your browser to a newer version to get the best experience on Human Metabolome Database. ...
https://hmdb.ca/spectra/ms_ms/2460974
Metabolome and transcriptome of the interaction between Ustilago maydis and Fusarium verticillioides in vitro. | John Innes...Metabolome and transcriptome of the interaction between Ustilago maydis and Fusarium verticillioides in vitro. | John Innes...
The metabolome and transcriptome of the maize-infecting fungi Ustilago maydis and Fusarium verticillioides were analyzed as the ... Metabolome and transcriptome of the interaction between Ustilago maydis and Fusarium verticillioides in vitro. 1st May 2012 ... The metabolome and transcriptome of the maize-infecting fungi Ustilago maydis and Fusarium verticillioides were analyzed as the ... Metabolome and transcriptome of the interaction between Ustilago maydis and Fusarium verticillioides in vitro. ...
https://www.jic.ac.uk/research-impact/publications/metabolome-and-transcriptome-of-the-interaction-between-ustilago-maydis-and-fusarium-verticillioides-in-vitro/
Disease-associated gut microbiome and metabolome changes in patients with chronic obstructive pulmonary disease | Nature...Disease-associated gut microbiome and metabolome changes in patients with chronic obstructive pulmonary disease | Nature...
While correlative, our results suggest that the faecal microbiome and metabolome of COPD patients are distinct from those of ... Here we examine the faecal microbiome and metabolome of COPD patients and healthy controls, finding 146 bacterial species ... 4: Faecal metabolome of COPD patients (n = 28) is distinguished from that of healthy individuals (n = 29) using a multi-omic ... 6: Integration of faecal microbiomes and metabolomes identifies a COPD-associated network.. ...
https://www.nature.com/articles/s41467-020-19701-0?error=cookies_not_supported&code=e21feeeb-e05b-415a-9e7b-0a06f63912c0
Human Metabolome DatabaseHuman Metabolome Database
Please upgrade your browser to a newer version to get the best experience on Human Metabolome Database. ... Gender-specific pathway differences in the human serum metabolome. Metabolomics. 2015;11(6):1815-1833. Epub 2015 Aug 4. [PubMed ...
https://hmdb.ca/metabolomic_categories/7661
Frontiers | Assessing Drought and Heat Stress-Induced Changes in the Cotton Leaf Metabolome and Their Relationship With...Frontiers | Assessing Drought and Heat Stress-Induced Changes in the Cotton Leaf Metabolome and Their Relationship With...
The objective of this study was to analyze the effect of water deficit and heat stress on the leaf metabolome of 22 genetically ... The objective of this study was to analyze the effect of water deficit and heat stress on the leaf metabolome of 22 genetically ... The leaf metabolome effectively summarizes stress-driven perturbations of the plant physiological status and represents an ... The leaf metabolome effectively summarizes stress-driven perturbations of the plant physiological status and represents an ...
https://www.frontiersin.org/articles/10.3389/fpls.2021.751868/full
Transcriptome and metabolome analyses provide insights into root and root-released organic anion responses to phosphorus...Transcriptome and metabolome analyses provide insights into root and root-released organic anion responses to phosphorus...
Transcriptome and metabolome analyses provide insights into root and root-released organic anion responses to phosphorus ... and analysed changes in the transcriptome and metabolome. Oat roots showed enhanced citrate and malate exudation after 4 weeks ...
https://pubmed.ncbi.nlm.nih.gov/29757407/
Answering biological questions by analysis of the strawberry metabolome | The James Hutton InstituteAnswering biological questions by analysis of the strawberry metabolome | The James Hutton Institute
Answering biological questions by analysis of the strawberry metabolome. Title. Answering biological questions by analysis of ... Printed from /publications/answering-biological-questions-analysis-strawberry-metabolome on 06/12/22 09:25:41 PM ...
https://www.hutton.ac.uk/publications/answering-biological-questions-analysis-strawberry-metabolome
Seeing the forest for the trees : retrieving plant secondary biochemical pathways from metabolome networksSeeing the forest for the trees : retrieving plant secondary biochemical pathways from metabolome networks
... Sandrien Desmet ( ... "Seeing the Forest for the Trees : Retrieving Plant Secondary Biochemical Pathways from Metabolome Networks." COMPUTATIONAL AND ... "Seeing the Forest for the Trees : Retrieving Plant Secondary Biochemical Pathways from Metabolome Networks." COMPUTATIONAL AND ... "Seeing the Forest for the Trees : Retrieving Plant Secondary Biochemical Pathways from Metabolome Networks." COMPUTATIONAL AND ...
https://biblio.ugent.be/publication/8686431
Dryad Data -- The induction of the fibroblast extracellular senescence metabolome is a dynamic processDryad Data -- The induction of the fibroblast extracellular senescence metabolome is a dynamic process
Data from: The induction of the fibroblast extracellular senescence metabolome is a dynamic process. James, Emma N.L., ... the extracellular senescence metabolome, or ESM). The post-mitotic phase of senescence is dynamic, making the detection of ... The induction of the fibroblast extracellular senescence metabolome is a dynamic process, Dryad, Dataset, https://doi.org/ ...
https://datadryad.org/stash/dataset/doi:10.5061/dryad.45747rs
Effects of exposure to water disinfection by-products in a swimming pool: A metabolome-wide association studyEffects of exposure to water disinfection by-products in a swimming pool: A metabolome-wide association study
Metabolome-wide association between DBP exposures and each metabolic feature was evaluated using multivariate normal (MVN) ... Effects of exposure to water disinfection by-products in a swimming pool: A metabolome-wide association study. DSpace/Manakin ... Keywords: Disinfection by-products, DBPs, Metabolome, LC-MS, Blood, Exposome. DOI: https://doi.org/10.1016/j.envint.2017.11.017 ...
https://dspace.library.uu.nl/handle/1874/374936
Maximizing Throughput and Metabolome Coverage with Dual Separation LC-MS for Improved Bioprocessing OutcomesMaximizing Throughput and Metabolome Coverage with Dual Separation LC-MS for Improved Bioprocessing Outcomes
Combining reversed-phase (RP) and HILIC separation in one integrated LC system increases metabolome coverage, improves ... Maximizing Throughput and Metabolome Coverage with Dual Separation LC-MS for Improved Bioprocessing Outcomes. ... Find out how to combine complementary separations in one analysis to increase metabolome coverage and reduce analysis time for ... Combining reversed-phase (RP) and HILIC separation in one integrated LC system increases metabolome coverage, improves ...
https://www.chromatographyonline.com/view/maximizing-throughput-and-metabolome-coverage-dual-separation-lc-ms-improved-bioprocessing-outcomes
Linking the abiotic stress metabolome to the genome and proteome of peanut | National Peanut BoardLinking the abiotic stress metabolome to the genome and proteome of peanut | National Peanut Board
Linking the abiotic stress metabolome to the genome and proteome of peanut ...
https://www.nationalpeanutboard.org/more/production-research-database/13240-1121.htm
The Thing Metabolome Repository family (XMRs): comparable untargeted metabolome databases for analyzing sample-specific unknown...
The Thing Metabolome Repository family (XMRs): comparable untargeted metabolome databases for analyzing sample-specific unknown ... The Thing Metabolome Repository family (XMRs): comparable untargeted metabolome databases for analyzing sample-specific unknown ... A set of application programming interfaces for the XMRs facilitates the use of metabolome data for large-scale analysis and ... The identification of unknown chemicals has emerged as a significant issue in untargeted metabolome analysis owing to the ...
https://www.nig.ac.jp/nig/2022/11/research-highlights/pr20221124.html
Metabolome- and genome-scale model analyses for engineering of Aureobasidium pullulans to enhance polymalic acid and malic acid...Metabolome- and genome-scale model analyses for engineering of Aureobasidium pullulans to enhance polymalic acid and malic acid...
Comparative metabolome analysis of sucrose- and glucose-based fermentation identified 81 intracellular metabolites and ... We showed that integrated metabolome- and genome-scale model analyses were an effective approach for engineering the metabolic ... Metabolome- and genome-scale model analyses for engineering of Aureobasidium pullulans to enhance polymalic acid and malic acid ...
https://biotechnologyforbiofuels.biomedcentral.com/articles/10.1186/s13068-018-1099-7/metrics
Changes in the milk metabolome of the giant panda (ailuropoda melanoleuca) with time after birth - three phases in early...Changes in the milk metabolome of the giant panda (ailuropoda melanoleuca) with time after birth - three phases in early...
Text. Filename: Zhang_etal_Plos_One_2015_Changes_in_the_milk_metabolome_of_the_giant_panda_ailuropoda_melanoleuca_with_time_ ... Changes in the milk metabolome of the giant panda (ailuropoda melanoleuca) with time after birth - three phases in early ... Changes in the milk metabolome of the giant panda (ailuropoda melanoleuca) with time after birth - three phases in early ...
https://strathprints.strath.ac.uk/55178/
The yeast metabolome addressed by electrospray ionization mass spectrometry: Initiation of a mass spectral library and its...The yeast metabolome addressed by electrospray ionization mass spectrometry: Initiation of a mass spectral library and its...
To address the capabilities of ESI-MS in detecting the metabolome of Saccharomyces cerevisiae, the in silico metabolome of this ... which could be assigned using the in silico metabolome. By this approach metabolic footprinting can advance from a ... organism was used as a template to present a theoretical metabolome. This showed that in combination with the specificity of MS ... To address the capabilities of ESI-MS in detecting the metabolome of Saccharomyces cerevisiae, the in silico metabolome of this ...
https://research.chalmers.se/publication/?id=92126
Differences in airway microbiome and metabolome of single lung transplant recipients | Respiratory Research | Full TextDifferences in airway microbiome and metabolome of single lung transplant recipients | Respiratory Research | Full Text
Airway metabolome distinguished the native lung from the allografts and an increased concentration of sphingosine-like ... Airway metabolome distinguishes the allografts from native lungs and is associated with distinct microbial communities, ... 16S rRNA microbiome analysis was performed on BAL bacterial pellets and supernatant used for metabolome, cytokines and ... To investigate the host-microbiome interactions, we characterized the airway microbiome and metabolome of the allograft ( ...
https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-020-01367-3
Multi-omic profiling reveals associations between the gut mucosal microbiome, the metabolome, and host DNA methylation...Multi-omic profiling reveals associations between the gut mucosal microbiome, the metabolome, and host DNA methylation...
MPH contributed to metabolome data analysis. QW, LT, JWKH and EG participated in the data analysis and result interpretation. ... Wang, Q., Ye, J., Fang, D. et al. Multi-omic profiling reveals associations between the gut mucosal microbiome, the metabolome ... Comparison of the mucosal metabolome between tumour tissues and normal tissues in CRC patients a. OPLS-DA scores plot of ... The microbial taxa that were associated with the colonic metabolome were included. As a result, the increase in genus ...
https://bmcmicrobiol.biomedcentral.com/articles/10.1186/s12866-020-01762-2
Maternal diet and the serum metabolome in pregnancy: robust dietary biomarkers generalizable to multi-ethnic birth cohorts ...Maternal diet and the serum metabolome in pregnancy: robust dietary biomarkers generalizable to multi-ethnic birth cohorts ...
Maternal diet and the serum metabolome in pregnancy: robust dietary biomarkers generalizable to multi-ethnic birth cohorts [ ... Maternal diet and the serum metabolome in pregnancy: robust dietary biomarkers generalizable to multi-ethnic birth cohorts [ ... Maternal diet and the serum metabolome in pregnancy: robust dietary biomarkers generalizable to multi-ethnic birth cohorts [ ...
https://www.phri.ca/publication/start-family-maternal-diet-and-the-serum-metabolome-in-pregnancy-robust-dietary-biomarkers-generalizable-to-a-multi-ethnic-birth-cohort/
Genetic and environmental variation impact the cuticular hydrocarbon metabolome on the stigmatic surfaces of maize | BMC Plant...Genetic and environmental variation impact the cuticular hydrocarbon metabolome on the stigmatic surfaces of maize | BMC Plant...
Alkenes accounted for 5-60% of the total hydrocarbon metabolome, and the majority of alkenes were monoenes with a double bond ... Only minor differences in the metabolome were observed on silks that were emerged into the external environment for 3- versus 6 ... The environmental influence on the metabolome was further investigated by growing inbred lines in 2 years, one of which was ... In summary, the surface hydrocarbon metabolome of silks is primarily governed by genotype and husk encasement status, with ...
https://bmcplantbiol.biomedcentral.com/articles/10.1186/s12870-019-2040-3
Co-edition METABOLITES issues: Fruit Metabolism and Metabolomics | Bordeaux MetabolomeCo-edition METABOLITES issues: 'Fruit Metabolism and Metabolomics' | Bordeaux Metabolome
Deux membres de la plateforme Facility, A. Moing & P. Pétriacq, sont co-editeurs dun numéro spécial sur "Fruit Metabolism and Metabolomics" dans le journal METABOLITES, et sont à la recherche darticles, de revues ou de communications courtes dans ce domaine.. Keywords : Fruit metabolomics, Developmental metabolomics, Spatial metabolomics, Lipidomics, Fruit metabolomic profiling, Central metabolism, Specialized metabolism, Mass spectrometry, Nuclear magnetic resonance spectroscopy, Omics data integration.. Submission deadline : 30 novembre 2019. https://www.mdpi.com/journal/metabolites/special_issues/Fruit_Metabolism. ...
https://metabolome.cgfb.u-bordeaux.fr/fr/news/co-edition-metabolites-issues-fruit-metabolism-and-metabolomics
Nitrogen metabolism - Yeast Metabolome Database
Please upgrade your browser to a newer version to get the best experience on Yeast Metabolome Database. ...
http://www.ymdb.ca/pathways/4?c=locus&d=up
Microbiome and metabolome modifying effects of several cardiovascular disease interventions in apo-E−/− mice | Microbiome |...Microbiome and metabolome modifying effects of several cardiovascular disease interventions in apo-E−/− mice | Microbiome |...
... in addition to the host fecal and serum metabolome. We observed major shifts in the composition of the gut microbiome of PSE ... and STAT all appeared to have considerable impact on the host serum metabolome, including alterations in several acylcarnitines ... Effect of cardiovascular disease interventions on the host serum metabolome. Serum metabolome OPLS-DA: a PSE (green) vs. HFC ( ... From: Microbiome and metabolome modifying effects of several cardiovascular disease interventions in apo-E−/− mice ...
https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-017-0246-x/figures/4
Integrative analysis of the microbiome and metabolome of the human intestinal mucosal surface reveals exquisite inter...Integrative analysis of the microbiome and metabolome of the human intestinal mucosal surface reveals exquisite inter...
Analysis of the metabolome-driven distribution of OTU phylogeny and function revealed clusters of clades that were both ... Conclusions The results suggest that microbes are syntropic with mucosal metabolome composition and therefore may be the source ... Analysis of the metabolome-driven distribution of OTU phylogeny and function revealed clusters of clades that were both ... Conclusions The results suggest that microbes are syntropic with mucosal metabolome composition and therefore may be the source ...
https://escholarship.org/uc/item/2kv644w0
Multigenerational Exposure to Uranium Changes Sperm Metabolome in Rats - Aix-Marseille UniversitéMultigenerational Exposure to Uranium Changes Sperm Metabolome in Rats - Aix-Marseille Université
Multigenerational Exposure to Uranium Changes Sperm Metabolome in Rats Stéphane Grison 1 Audrey Legendre 1 Ljubica Svilar 2 ... Multigenerational Exposure to Uranium Changes Sperm Metabolome in Rats. International Journal of Molecular Sciences, 2022, 23 ( ...
https://hal-amu.archives-ouvertes.fr/hal-03791887
Integration of datasets from different analytical techniques to assess the impact of nutrition on human metabolome.<...
Integration of datasets from different analytical techniques to assess the impact of nutrition on human metabolome. Frontiers ... Integration of datasets from different analytical techniques to assess the impact of nutrition on human metabolome. In: ... Integration of datasets from different analytical techniques to assess the impact of nutrition on human metabolome. / Vernocchi ... Integration of datasets from different analytical techniques to assess the impact of nutrition on human metabolome.. ...
https://moh-it.pure.elsevier.com/en/publications/integration-of-datasets-from-different-analytical-techniques-to-a
Saliva metabolome alterations after acute stress - ePrints - Newcastle UniversitySaliva metabolome alterations after acute stress - ePrints - Newcastle University
Saliva metabolome alterations after acute stress. Lookup NU author(s): Professor Melissa BatesonORCiD ... Our results provide a fingerprint of the acute effect of psychological stress on the metabolome and suggest candidate ...
https://eprints.ncl.ac.uk/287753
AMON: annotation of metabolite origins via networks to integrate microbiome and metabolome data | BMC Bioinformatics | Full TextAMON: annotation of metabolite origins via networks to integrate microbiome and metabolome data | BMC Bioinformatics | Full Text
AMON is an open-source bioinformatics application that can be used to annotate which compounds in the metabolome could have ... Through integrated analysis of microbiome and metabolome data, mechanistic relationships between microbial communities and host ... "metabolome". Host-associated metabolomes represent a complex milieu of compounds that can have different origins, including the ... In addition, the metabolome contains metabolic products of these compounds, i.e. metabolites, that can result from host and/or ...
https://bmcbioinformatics.biomedcentral.com/articles/10.1186/s12859-019-3176-8
Microbiome and metabolomeMetabolitesMass-spectrometrySerum metabolomeAnalysesMetabolicMicrobiotaMetaboliteProteome and metabolomeTranscriptome and metabolomeFood MetabolomeCircadian metabolomeAbioticUrineGenomeRepositoryMetabolomicsMicrobialCompoundsUrinaryMetabolismCorrelationMaternalAcuteOrganismAnalysisInteractionsDatabaseBacterialDataDifferencesSignificantlyHumanProfilesChemicalsExamineInteractionInfluencePlantStudy
Microbiome and metabolome6
  • Here we examine the faecal microbiome and metabolome of COPD patients and healthy controls, finding 146 bacterial species differing between the two groups. (nature.com)
  • While correlative, our results suggest that the faecal microbiome and metabolome of COPD patients are distinct from those of healthy individuals, and may thus aid in the search for biomarkers for COPD. (nature.com)
  • To investigate the host-microbiome interactions, we characterized the airway microbiome and metabolome of the allograft (transplanted lung) and native lung of single lung transplant recipients. (biomedcentral.com)
  • Airway metabolome distinguishes the allografts from native lungs and is associated with distinct microbial communities, suggesting a functional relationship between the local microbiome and metabolome. (biomedcentral.com)
  • Through integrated analysis of microbiome and metabolome data, mechanistic relationships between microbial communities and host phenotypes can be better understood. (biomedcentral.com)
  • She has led observational studies on the neonatal microbiome and metabolome, and facilitates ongoing translational research in neonates, particularly in relation to necrotising enterocolitis and late onset sepsis development, prevention, diagnosis and treatment. (medela.com)
Metabolites13
  • Charting the Human Metabolome The success of a database of metabolites has whetted researchers' appetites for more. (the-scientist.com)
  • There are estimations that the human metabolome is in the order of thousands of metabolites, but there are maybe 20,000 for microbes and 200,000 for plants," says Christoph Steinbeck of the European Bioinformatics Institute (EBI) in Cambridge. (the-scientist.com)
  • Several serum metabolites are independent indicators of chronological age and some of these accumulate outside senescent fibroblasts independently of cell cycle arrest, repairable DNA breaks and cell size (the extracellular senescence metabolome, or ESM). (datadryad.org)
  • As such a resource, we released databases, Food-, Plant-, and Thing- Metabolome Repository (http://metabolites.in/foods, http://metabolites.in/plants, and http://metabolites.in/things, referred to as XMRs) in which the sample-specific localization of unknowns detected by liquid chromatography-mass spectrometry in a wide variety of samples can be examined, helping to discover and prioritize the unknowns. (nig.ac.jp)
  • Airway metabolome distinguished the native lung from the allografts and an increased concentration of sphingosine-like metabolites that negatively correlated with abundance of bacteria from phyla Proteobacteria . (biomedcentral.com)
  • Conclusions The results suggest that microbes are syntropic with mucosal metabolome composition and therefore may be the source of and/or dependent upon gut epithelial metabolites. (escholarship.org)
  • AMON is an open-source bioinformatics application that can be used to annotate which compounds in the metabolome could have been produced by bacteria present or the host, to evaluate pathway enrichment of host verses microbial metabolites, and to visualize which compounds may have been produced by host versus microbial enzymes in KEGG pathway maps. (biomedcentral.com)
  • We examined whether machine learning (ML) tools applied to the human plasma metabolome could consistently identify and prioritize metabolites implicated in sepsis survivorship, and whether these methods improved upon conventional statistical approaches. (springeropen.com)
  • Across the plasma metabolome, the 13 metabolites with the strongest linkage to mortality defined through an ensemble ML importance score included lactate, bilirubin, kynurenine, glycochenodeoxycholate, phenylalanine, and others. (springeropen.com)
  • Conventional statistical methods such as logistic regression may have important limitations when applied to data with high degrees of internal correlation (including the metabolome), missingness, subclass heterogeneity, and imbalance between exposures (metabolites) and outcomes-frequent challenges in high-dimensional human biologic data in critically cohorts. (springeropen.com)
  • However, less focus has been placed on how robustly and consistently ML could enhance biologic discovery through statistical mining of the metabolome to identify metabolites may show the strongest links with clinical outcomes. (springeropen.com)
  • In the present study, we hypothesized that parallel and ensemble ML methods could facilitate identification of individual metabolites potentially implicated in sepsis survivorship using gas chromatography-liquid chromatography (GC/LC) mass spectrometry profiling of the human metabolome. (springeropen.com)
  • We develop and use liquid chromatography and capillary electrophoresis-mass spectrometry-based (LC-MS, CE-MS) methods for in-depth characterization and quantification of complex lipids ( lipidome ), polar metabolites ( metabolome ), various exogenous compounds such as food components and drugs ( exposome ), and proteins ( proteome ). (cas.cz)
Mass-spectrometry5
  • 16S rRNA microbiome analysis was performed on BAL bacterial pellets and supernatant used for metabolome, cytokines and acetylated proline-glycine-proline (Ac-PGP) measurement by liquid chromatography-high-resolution mass spectrometry. (biomedcentral.com)
  • BASF Metabolome Solutions GmbH is the expert service provider of Mass Spectrometry-based Biological Analytics for customers within and outside of BASF. (basf.com)
  • Several methods based on mass spectrometry have been developed to analyse the metabolome in blood and urine samples (polyphenols, sex steroids, and intermediate metabolism). (who.int)
  • Analytical platform for metabolome analysis of microbial cells using methyl chloroformate derivatization followed by gas chromatography-mass spectrometry (GC-MS). Nature Protocols 5: 1709 - 1729. (drchrispook.com)
  • Dr. Nissim is a biochemist and a pioneer in the application of stable isotopes, mass spectrometry, and nuclear magnetic resonance to study metabolome and fluxome and their coupling to genome in normal and disease states. (chop.edu)
Serum metabolome1
  • Effect of cardiovascular disease interventions on the host serum metabolome. (biomedcentral.com)
Analyses3
  • Several applications of XMRs, including integrated metabolome and genome analyses, are presented. (nig.ac.jp)
  • Please use the data with appropriate knowledge for untargeted metabolome analyses using LC-MS. (metabolites.in)
  • However, large-scale metabolome studies in children combining analyses of these biological fluids are lacking. (biomedcentral.com)
Metabolic2
  • Metabolome-wide association between DBP exposures and each metabolic feature was evaluated using multivariate normal (MVN) models. (uu.nl)
  • The response in whole plant tissues may be different and we have therefore investigated the response of Arabidopsis roots to menadione treatment, analyzing the transcriptome, metabolome and key metabolic fluxes with focus on primary as well as secondary metabolism. (ox.ac.uk)
Microbiota2
  • Modifying the maternal microbiota alters the gut-brain metabolome and prevents emotional dysfunction in the adult offspring of obese dams. (ox.ac.uk)
  • Oral microbiota contribute significantly to the WMS metabolome . (bvsalud.org)
Metabolite4
  • Figure2: Metabolite and gene candidates found in the integrated metabolome and genome analysis. (nig.ac.jp)
  • Here, we sought to characterise the major determinants of the child metabolome and to define metabolite associations with age, sex, BMI and dietary habits in European children, by exploiting a unique biobank established as part of the Human Early-Life Exposome project ( http://www.projecthelix.eu ). (biomedcentral.com)
  • Daniel Globisch, a postdoctoral fellow in the Janda laboratory, studied the available literature referencing the metabolome of the nematode and pinpointed the metabolite source. (chromatographyonline.com)
  • The Ph.D. project aims to focus on novel approaches for comprehensive characterization of the metabolome and lipidome in biological samples, specifically, (i) merging targeted and untargeted methods, (ii) increasing the coverage of spectral libraries used for metabolite annotation, and (iii) using bioinformatics tools for visualization and interpretation of the data obtained within metabolomics and lipidomics studies. (cas.cz)
Proteome and metabolome1
  • We believe that the ultimate goals of urine profiling of proteome and metabolome should be (i) to identify non-invasive diagnostic and prognostic biomarkers of bladder diseases, (ii) to better understand the biology of bladder diseases, and (iii) to determine the therapeutic strategies targeting the critical pathways of various bladder diseases. (medscape.com)
Transcriptome and metabolome1
  • We conducted a hydroponic experiment and measured root morphology and organic anion exudation, and analysed changes in the transcriptome and metabolome. (nih.gov)
Food Metabolome2
  • We are delighted to announce that the 1st International Workshop on "The Food Metabolome and Biomarkers for Dietary Exposure" will be held on 4-5 July 2013 at the 9th International Conference of the Metabolomics Society in Glasgow, Scotland. (who.int)
  • Associations between growth It is currently being applied to large food metabolome (Scalbert et al. (who.int)
Circadian metabolome1
  • By analyzing the liver metabolome of mice deficient in the expression of the dopamine D2 receptor (D2R) in striatal medium spiny neurons, the researchers found profound changes in the liver circadian metabolome compared to control mice. (yidashuzi.com)
Abiotic1
  • Investigation of the Influence of PGPR on plant metabolome under abiotic stresses. (umd.edu)
Urine4
  • We have established a pan-European reference metabolome for urine and serum of healthy children and gathered critical resources not previously available for future investigations into the influence of the metabolome on child health. (biomedcentral.com)
  • The team analysed the urinary metabolome of infected and uninfected patients, identifying one particular protein that became elevated in the urine of infected patients. (chromatographyonline.com)
  • On the evening of the steroid-free day, the participants were started on overnight urine collection for analysis of the steroid metabolome. (endocrinologyadvisor.com)
  • Analysis of the steroid metabolome in the overnight urine collection showed that individuals with detectable serum cortisol also had secretion of several other glucocorticoid and mineralocorticoids. (endocrinologyadvisor.com)
Genome4
  • In 2004, with funding from the Canadian Foundation for Innovation and Genome Canada, Wishart began the Human Metabolome Database (HMDB), part of Genome Canada's Human Metabolome Project. (the-scientist.com)
  • The leaf metabolome effectively summarizes stress-driven perturbations of the plant physiological status and represents an intermediate phenotype that bridges the plant genome and phenome. (frontiersin.org)
  • Here we demonstrate how to link genome (Ensembl), proteome (UniProt), and metabolome (ChEBI) data using federated queries that leverage the SPARQL endpoint of Rhea (https://sparql.rhea-db.org/sparql) and data from these other resources. (figshare.com)
  • 2020. A Genome-wide Association Study Discovers 46 Loci of the Human Metabolome in the Hispanic Community Health Study/Study of Latinos. . (unc.edu)
Repository2
  • Things Metabolome Repository is being constructed for data mining and further use of unknown compounds. (metabolites.in)
  • For the next generation discovery and use of unknown compounds, Things Metabolome Repository accumulates and provides mass spectral data of unknowns from various things in a "comparable" way. (metabolites.in)
Metabolomics2
  • By Megan Scudellari Courtesy of The Human Metabolome Project After researchers coined the term "metabolomics" in 1998, it appeared in only one or two papers per year. (the-scientist.com)
  • To crunch the metabolome data, Dashwood's team utilized the Integrated Metabolomics Analysis Core facility established by Arul Jayaraman, PhD, at the Texas A&M College of Engineering. (tamhsc.edu)
Microbial2
  • The microbial conversion of carbohydrates and other food components leads to the formation of a large number of compounds that affect the host metabolome and have beneficial or adverse effects on human health. (elsevier.com)
  • WMS spectral exhibited greater inter-individual variation than those of PS or plasma (6.7 and 3.6 fold, respectively), likely reflecting diversity of microbial metabolomes . (bvsalud.org)
Compounds1
  • Host-associated metabolomes represent a complex milieu of compounds that can have different origins, including the diet of the host organism and a variety of environmental exposures such as pollutants. (biomedcentral.com)
Urinary1
  • Her current research involves exploration of the canine urinary metabolome and the relationship to diet. (northpointpets.com)
Metabolism1
  • The metabolome is the all set of low molecular weight chemicals that are produced by cells during metabolism and provides a direct functional readout of cellular activity and biomolecular, nutritional and functional status. (onogen.com)
Correlation2
  • Identification and correlation of novel metabolome profiles associated with specific pathological microbiome signatures may help guide personalized treatment of host disease states [ 16 ]. (biomedcentral.com)
  • Given the strengths and weaknesses of the existing methods and considering the characteristics of different types of omics data, we designed a special strategy, called Generalized coRrelation analysis for Metabolome and Microbiome (GRaMM), for the intercorrelation discovery between the metabolome and microbiome. (edu.hk)
Maternal1
  • Taken together, we show that maternal probiotic supplementation exerts a long-lasting effect on offspring neuroplasticity and the offspring gut-liver-brain metabolome, increasing resilience to emotional dysfunction induced by maternal obesity. (ox.ac.uk)
Acute1
  • In addition, they found that activation of dopaminergic circuits by acute cocaine administration reprograms the circadian liver metabolome. (yidashuzi.com)
Organism2
  • To address the capabilities of ESI-MS in detecting the metabolome of Saccharomyces cerevisiae, the in silico metabolome of this organism was used as a template to present a theoretical metabolome. (chalmers.se)
  • Atmospheric chemistry is like metabolome of just one organism, which is the globe. (themetabolomist.com)
Analysis4
  • Combining reversed-phase (RP) and HILIC separation in one integrated LC system increases metabolome coverage, improves efficiency, and reduces analysis time of cell media. (chromatographyonline.com)
  • A set of application programming interfaces for the XMRs facilitates the use of metabolome data for large-scale analysis and data mining. (nig.ac.jp)
  • Statistical analysis of the footprinting data revealed discriminating ions, which could be assigned using the in silico metabolome. (chalmers.se)
  • Analysis of the metabolome-driven distribution of OTU phylogeny and function revealed clusters of clades that were both metabolically and metagenomically similar. (escholarship.org)
Interactions1
  • In summary, the surface hydrocarbon metabolome of silks is primarily governed by genotype and husk encasement status, with smaller impacts of environment and genotype-by-environment interactions. (biomedcentral.com)
Database1
  • Please upgrade your browser to a newer version to get the best experience on Human Metabolome Database. (hmdb.ca)
Bacterial1
  • Determining bacterial and host contributions to the human salivary metabolome. (bvsalud.org)
Data3
  • This has led to the next challenge in this research field: retrieving biochemical pathway information from the various types of networks that can be constructed from metabolome data. (ugent.be)
  • this is a major bottleneck for the accumulation of reusable metabolome data in systems biology. (nig.ac.jp)
  • However, there is still a lack of sufficient data on the metabolome and lipidome characterizing biofluids and tissues which can be easily accessible and reused at any time for future studies. (cas.cz)
Differences1
  • Only minor differences in the metabolome were observed on silks that were emerged into the external environment for 3- versus 6-days. (biomedcentral.com)
Significantly1
  • This study reveals that the composition of the cuticular hydrocarbon metabolome on silks is affected significantly by genetic factors, and is therefore amenable to dissection using quantitative genetic approaches. (biomedcentral.com)
Human2
  • Integration of datasets from different analytical techniques to assess the impact of nutrition on human metabolome. (elsevier.com)
  • Human Metabolome Technologies America Inc. (humanmetabolome.com)
Profiles1
  • Some of our current research is looking into how gestational diabetes can be predicted around week 10 instead of around week 28 based on omics research tools such as women's metabolome profiles. (medlineplus.gov)
Chemicals1
  • explored the relationship between the intestinal metabolome (all chemicals present in the intestine) and CDI through fecal metabolomic profiling. (cdc.gov)
Examine1
  • To test the hypotheses that genetics and environment influence the accumulation of surface hydrocarbons on silks and to examine the breadth of metabolome compositions across diverse germplasm, cuticular hydrocarbons were analyzed on husk-encased silks and silks that emerged from the husk leaves from 32 genetically diverse maize inbred lines, most of which are commonly utilized in genetics experiments. (biomedcentral.com)
Interaction1
  • Metabolome and transcriptome of the interaction between Ustilago maydis and Fusarium verticillioides in vitro. (jic.ac.uk)
Influence1
  • The environmental influence on the metabolome was further investigated by growing inbred lines in 2 years, one of which was warmer and wetter. (biomedcentral.com)
Plant3
  • Desmet S, Brouckaert M, Boerjan W, Morreel K. Seeing the forest for the trees : retrieving plant secondary biochemical pathways from metabolome networks. (ugent.be)
  • S. Desmet, M. Brouckaert, W. Boerjan, and K. Morreel, "Seeing the forest for the trees : retrieving plant secondary biochemical pathways from metabolome networks," COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL , vol. 19, pp. 72-85, 2021. (ugent.be)
  • The results also showed that CSBS impacted the soil microbiome and plant metabolome. (cdc.gov)
Study2
  • The objective of this study was to analyze the effect of water deficit and heat stress on the leaf metabolome of 22 genetically diverse accessions of upland cotton grown in the Arizona low desert over two consecutive years. (frontiersin.org)
  • In 2004, when the download Also been for youth, the Solomon Note In the such Keynesian story, postcards brought 10 cover to Movie, although then 13 of Tower's 89 local metabolomes had reflected to find s study. (schuetzenverein-odenbach.de)
Diel investments in metabolite production and consumption in a model microbial system | The ISME Journal
Diel investments in metabolite production and consumption in a model microbial system | The ISME Journal (nature.com)
Frontiers | Metabolic Profiling at COVID-19 Onset Shows Disease Severity and Sex-Specific Dysregulation
Frontiers | Metabolic Profiling at COVID-19 Onset Shows Disease Severity and Sex-Specific Dysregulation (frontiersin.org)
Frontiers | Vegan Diet Is Associated With Favorable Effects on the Metabolic Performance of Intestinal Microbiota: A Cross...
Frontiers | Vegan Diet Is Associated With Favorable Effects on the Metabolic Performance of Intestinal Microbiota: A Cross... (frontiersin.org)
Group Companies
Group Companies (basf.com)
Breast cancer quantitative proteome and proteogenomic landscape | Nature Communications
Breast cancer quantitative proteome and proteogenomic landscape | Nature Communications (nature.com)
PDF) The role of supplementary dietary antioxidants on immune response in puppies
PDF) The role of supplementary dietary antioxidants on immune response in puppies (researchgate.net)
Concussions Detected by Checking for Dents in the Metabolome
Concussions Detected by Checking for Dents in the Metabolome (genengnews.com)
Gut Bacteria Profile Remains Stable With Healthy Aging
Gut Bacteria Profile Remains Stable With Healthy Aging (medscape.com)
Discrimination and the Brain-Gut-Microbiome (BGM) Axis - Full Text View - ClinicalTrials.gov
Discrimination and the Brain-Gut-Microbiome (BGM) Axis - Full Text View - ClinicalTrials.gov (clinicaltrials.gov)
Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function | Nature Communications
Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function | Nature Communications (nature.com)
PDF) The Powdering Process with a Set of Ceramic Mills for Green Tea Promoted Catechin Extraction and the ROS Inhibition Effect
PDF) The Powdering Process with a Set of Ceramic Mills for Green Tea Promoted Catechin Extraction and the ROS Inhibition Effect (researchgate.net)
Metabolome and transcriptome of the interaction between Ustilago maydis and Fusarium verticillioides in vitro. | John Innes...
Metabolome and transcriptome of the interaction between Ustilago maydis and Fusarium verticillioides in vitro. | John Innes... (jic.ac.uk)
Frontiers | A Testosterone Metabolite 19-Hydroxyandrostenedione Induces Neuroendocrine Trans-Differentiation of Prostate Cancer...
Frontiers | A Testosterone Metabolite 19-Hydroxyandrostenedione Induces Neuroendocrine Trans-Differentiation of Prostate Cancer... (frontiersin.org)
IJERPH | Free Full-Text | Nonylphenol Toxicity Evaluation and Discovery of Biomarkers in Rat Urine by a Metabolomics Strategy...
IJERPH | Free Full-Text | Nonylphenol Toxicity Evaluation and Discovery of Biomarkers in Rat Urine by a Metabolomics Strategy... (mdpi.com)
Severe preeclampsia is associated with a higher relative abundance of Prevotella bivia in the vaginal microbiota | Scientific...
Severe preeclampsia is associated with a higher relative abundance of Prevotella bivia in the vaginal microbiota | Scientific... (nature.com)
Bacterial Overgrowth Syndrome: Background, Pathophysiology, Epidemiology
Bacterial Overgrowth Syndrome: Background, Pathophysiology, Epidemiology (medscape.com)
Frontiers | Assessing Drought and Heat Stress-Induced Changes in the Cotton Leaf Metabolome and Their Relationship With...
Frontiers | Assessing Drought and Heat Stress-Induced Changes in the Cotton Leaf Metabolome and Their Relationship With... (frontiersin.org)
Gut microbiota and human NAFLD: disentangling microbial signatures from metabolic disorders | Nature Reviews Gastroenterology &...
Gut microbiota and human NAFLD: disentangling microbial signatures from metabolic disorders | Nature Reviews Gastroenterology &... (nature.com)
Applied Sciences | Free Full-Text | Myths and Realities about Genetically Modified Food: A Risk-Benefit Analysis
Applied Sciences | Free Full-Text | Myths and Realities about Genetically Modified Food: A Risk-Benefit Analysis (mdpi.com)
Frontiers | The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication
Frontiers | The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication (frontiersin.org)
Our Services
Our Services (basf.com)
Fresh Data Confirm Healthy Plant Foods Link to Lower Diabetes Risk
Fresh Data Confirm Healthy Plant Foods Link to Lower Diabetes Risk (medscape.com)
Ultraprocessed Food Adversely Impacts Metabolome in Kids
Ultraprocessed Food Adversely Impacts Metabolome in Kids (medscape.com)
Is There Hope in the Fight Against Aging?
Is There Hope in the Fight Against Aging? (medscape.com)
NIH and NFL tackle concussion research | NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development
NIH and NFL tackle concussion research | NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development (nichd.nih.gov)
SRP Centers Expand Scope to Address COVID-19 Research Needs
SRP Centers Expand Scope to Address COVID-19 Research Needs (niehs.nih.gov)