Generic term for diseases caused by an abnormal metabolic process. It can be congenital due to inherited enzyme abnormality (METABOLISM, INBORN ERRORS) or acquired due to disease of an endocrine organ or failure of a metabolically important organ such as the liver. (Stedman, 26th ed)
Errors in metabolic processes resulting from inborn genetic mutations that are inherited or acquired in utero.
A collective term for nutritional disorders resulting from poor absorption or nutritional imbalance, and metabolic disorders resulting from defects in biosynthesis (ANABOLISM) or breakdown (CATABOLISM) of endogenous substances.
A status with BODY WEIGHT that is grossly above the acceptable or desirable weight, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
Physiological processes in biosynthesis (anabolism) and degradation (catabolism) of LIPIDS.
The chemical reactions involved in the production and utilization of various forms of energy in cells.
Disorders affecting amino acid metabolism. The majority of these disorders are inherited and present in the neonatal period with metabolic disturbances (e.g., ACIDOSIS) and neurologic manifestations. They are present at birth, although they may not become symptomatic until later in life.
A cluster of metabolic risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components of metabolic syndrome X include excess ABDOMINAL FAT; atherogenic DYSLIPIDEMIA; HYPERTENSION; HYPERGLYCEMIA; INSULIN RESISTANCE; a proinflammatory state; and a prothrombotic (THROMBOSIS) state. (from AHA/NHLBI/ADA Conference Proceedings, Circulation 2004; 109:551-556)
Morphological and physiological development of FETUSES.
A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
Specialized connective tissue composed of fat cells (ADIPOCYTES). It is the site of stored FATS, usually in the form of TRIGLYCERIDES. In mammals, there are two types of adipose tissue, the WHITE FAT and the BROWN FAT. Their relative distributions vary in different species with most adipose tissue being white.
Nutrition of FEMALE during PREGNANCY.
A sirtuin family member found primarily in the CELL NUCLEUS. It is an NAD-dependent deacetylase with specificity towards HISTONES and a variety of proteins involved in gene regulation.
A group of disorders which have in common elevations of tyrosine in the blood and urine secondary to an enzyme deficiency. Type I tyrosinemia features episodic weakness, self-mutilation, hepatic necrosis, renal tubular injury, and seizures and is caused by a deficiency of the enzyme fumarylacetoacetase. Type II tyrosinemia features INTELLECTUAL DISABILITY, painful corneal ulcers, and keratoses of the palms and plantar surfaces and is caused by a deficiency of the enzyme TYROSINE TRANSAMINASE. Type III tyrosinemia features INTELLECTUAL DISABILITY and is caused by a deficiency of the enzyme 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE. (Menkes, Textbook of Child Neurology, 5th ed, pp42-3)
A photoelectric method of recording an X-ray image on a coated metal plate, using low-energy photon beams, long exposure time and dry chemical developers.
The processes whereby the internal environment of an organism tends to remain balanced and stable.
TRANSCRIPTION FACTORS that are activated by ligands and heterodimerize with RETINOID X RECEPTORS and bind to peroxisome proliferator response elements in the promoter regions of target genes.
Consumption of excessive DIETARY FATS.
Cells in the body that store FATS, usually in the form of TRIGLYCERIDES. WHITE ADIPOCYTES are the predominant type and found mostly in the abdominal cavity and subcutaneous tissue. BROWN ADIPOCYTES are thermogenic cells that can be found in newborns of some species and hibernating mammals.
The identification of selected parameters in newborn infants by various tests, examinations, or other procedures. Screening may be performed by clinical or laboratory measures. A screening test is designed to sort out healthy neonates (INFANT, NEWBORN) from those not well, but the screening test is not intended as a diagnostic device, rather instead as epidemiologic.
Pathological conditions resulting from abnormal anabolism or catabolism of lipids in the body.
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Lipid infiltration of the hepatic parenchymal cells resulting in a yellow-colored liver. The abnormal lipid accumulation is usually in the form of TRIGLYCERIDES, either as a single large droplet or multiple small droplets. Fatty liver is caused by an imbalance in the metabolism of FATTY ACIDS.
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
Fatty tissue composed of WHITE ADIPOCYTES and generally found directly under the skin (SUBCUTANEOUS FAT) and around the internal organs (ABDOMINAL FAT). It has less vascularization and less coloration than the BROWN FAT. White fat provides heat insulation, mechanical cushion, and source of energy.
Disruptions of the rhythmic cycle of bodily functions or activities.
Ocular disorders attendant upon non-ocular disease or injury.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
A subclass of histone deacetylases that are NAD-dependent. Several members of the SIRTUINS family are included in this subclass.
A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.
A group of autosomal recessive disorders marked by a deficiency of the hepatic enzyme PHENYLALANINE HYDROXYLASE or less frequently by reduced activity of DIHYDROPTERIDINE REDUCTASE (i.e., atypical phenylketonuria). Classical phenylketonuria is caused by a severe deficiency of phenylalanine hydroxylase and presents in infancy with developmental delay; SEIZURES; skin HYPOPIGMENTATION; ECZEMA; and demyelination in the central nervous system. (From Adams et al., Principles of Neurology, 6th ed, p952).
A large group of diseases which are characterized by a low prevalence in the population. They frequently are associated with problems in diagnosis and treatment.
A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.
The differentiation of pre-adipocytes into mature ADIPOCYTES.
Glucose in blood.
Nutrition of a mother which affects the health of the FETUS and INFANT as well as herself.
An inherited disorder of connective tissue with extensive degeneration and calcification of ELASTIC TISSUE primarily in the skin, eye, and vasculature. At least two forms exist, autosomal recessive and autosomal dominant. This disorder is caused by mutations of one of the ATP-BINDING CASSETTE TRANSPORTERS. Patients are predisposed to MYOCARDIAL INFARCTION and GASTROINTESTINAL HEMORRHAGE.
Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.
Abnormalities in the serum levels of LIPIDS, including overproduction or deficiency. Abnormal serum lipid profiles may include high total CHOLESTEROL, high TRIGLYCERIDES, low HIGH DENSITY LIPOPROTEIN CHOLESTEROL, and elevated LOW DENSITY LIPOPROTEIN CHOLESTEROL.
The amount of fat or lipid deposit at a site or an organ in the body, an indicator of body fat status.
A nuclear transcription factor. Heterodimerization with RETINOID X RECEPTOR ALPHA is important in regulation of GLUCOSE metabolism and CELL GROWTH PROCESSES. It is a target of THIAZOLIDINEDIONES for control of DIABETES MELLITUS.
Acquired or inborn metabolic diseases that produce brain dysfunction or damage. These include primary (i.e., disorders intrinsic to the brain) and secondary (i.e., extracranial) metabolic conditions that adversely affect cerebral function.
The generation of heat in order to maintain body temperature. The uncoupled oxidation of fatty acids contained within brown adipose tissue and SHIVERING are examples of thermogenesis in MAMMALS.
A continuous cell line that is a substrain of SWISS 3T3 CELLS developed though clonal isolation. The mouse fibroblast cells undergo an adipose-like conversion as they move to a confluent and contact-inhibited state.
Salts and esters of the 7-carbon saturated monocarboxylic acid heptanoic acid.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
Errors in the metabolism of LIPIDS resulting from inborn genetic MUTATIONS that are heritable.
A homologous family of regulatory enzymes that are structurally related to the protein silent mating type information regulator 2 (Sir2) found in Saccharomyces cerevisiae. Sirtuins contain a central catalytic core region which binds NAD. Several of the sirtuins utilize NAD to deacetylate proteins such as HISTONES and are categorized as GROUP III HISTONE DEACETYLASES. Several other sirtuin members utilize NAD to transfer ADP-RIBOSE to proteins and are categorized as MONO ADP-RIBOSE TRANSFERASES, while a third group of sirtuins appears to have both deacetylase and ADP ribose transferase activities.
The consequences of exposing the FETUS in utero to certain factors, such as NUTRITION PHYSIOLOGICAL PHENOMENA; PHYSIOLOGICAL STRESS; DRUGS; RADIATION; and other physical or chemical factors. These consequences are observed later in the offspring after BIRTH.
Mutant mice exhibiting a marked obesity coupled with overeating, hyperglycemia, hyperinsulinemia, marked insulin resistance, and infertility when in a homozygous state. They may be inbred or hybrid.
An infant during the first month after birth.
A nuclear transcription factor. It is activated by PROSTACYCLIN.
Fatty tissue under the SKIN through out the body.
Organic compounds that contain 1,2-diphenylethylene as a functional group.
De novo fat synthesis in the body. This includes the synthetic processes of FATTY ACIDS and subsequent TRIGLYCERIDES in the LIVER and the ADIPOSE TISSUE. Lipogenesis is regulated by numerous factors, including nutritional, hormonal, and genetic elements.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
Fatty tissue inside the ABDOMINAL CAVITY, including visceral fat and retroperitoneal fat. It is the most metabolically active fat in the body and easily accessible for LIPOLYSIS. Increased visceral fat is associated with metabolic complications of OBESITY.
A nuclear transcription factor. Heterodimerization with PPAR GAMMA is important in regulation of GLUCOSE metabolism and CELL GROWTH PROCESSES.
A subtype of striated muscle, attached by TENDONS to the SKELETON. Skeletal muscles are innervated and their movement can be consciously controlled. They are also called voluntary muscles.
Intracellular receptors that can be found in the cytoplasm or in the nucleus. They bind to extracellular signaling molecules that migrate through or are transported across the CELL MEMBRANE. Many members of this class of receptors occur in the cytoplasm and are transported to the CELL NUCLEUS upon ligand-binding where they signal via DNA-binding and transcription regulation. Also included in this category are receptors found on INTRACELLULAR MEMBRANES that act via mechanisms similar to CELL SURFACE RECEPTORS.
A condition characterized by an abnormally elevated concentration of KETONE BODIES in the blood (acetonemia) or urine (acetonuria). It is a sign of DIABETES COMPLICATION, starvation, alcoholism or a mitochondrial metabolic disturbance (e.g., MAPLE SYRUP URINE DISEASE).
A test to determine the ability of an individual to maintain HOMEOSTASIS of BLOOD GLUCOSE. It includes measuring blood glucose levels in a fasting state, and at prescribed intervals before and after oral glucose intake (75 or 100 g) or intravenous infusion (0.5 g/kg).
Reduction in caloric intake without reduction in adequate nutrition. In experimental animals, caloric restriction has been shown to extend lifespan and enhance other physiological variables.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Intracellular signaling protein kinases that play a signaling role in the regulation of cellular energy metabolism. Their activity largely depends upon the concentration of cellular AMP which is increased under conditions of low energy or metabolic stress. AMP-activated protein kinases modify enzymes involved in LIPID METABOLISM, which in turn provide substrates needed to convert AMP into ATP.
Various physiological or molecular disturbances that impair ENDOPLASMIC RETICULUM function. It triggers many responses, including UNFOLDED PROTEIN RESPONSE, which may lead to APOPTOSIS; and AUTOPHAGY.
Regular course of eating and drinking adopted by a person or animal.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
The metabolic process of breaking down LIPIDS to release FREE FATTY ACIDS, the major oxidative fuel for the body. Lipolysis may involve dietary lipids in the DIGESTIVE TRACT, circulating lipids in the BLOOD, and stored lipids in the ADIPOSE TISSUE or the LIVER. A number of enzymes are involved in such lipid hydrolysis, such as LIPASE and LIPOPROTEIN LIPASE from various tissues.
Complex sets of enzymatic reactions connected to each other via their product and substrate metabolites.
Polypeptides produced by the ADIPOCYTES. They include LEPTIN; ADIPONECTIN; RESISTIN; and many cytokines of the immune system, such as TUMOR NECROSIS FACTOR-ALPHA; INTERLEUKIN-6; and COMPLEMENT FACTOR D (also known as ADIPSIN). They have potent autocrine, paracrine, and endocrine functions.
A bile salt formed in the liver by conjugation of chenodeoxycholate with taurine, usually as the sodium salt. It acts as detergent to solubilize fats in the small intestine and is itself absorbed. It is used as a cholagogue and choleretic.
Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. Fatty acids are saturated and unsaturated (FATTY ACIDS, UNSATURATED). (Grant & Hackh's Chemical Dictionary, 5th ed)
The chemical reactions that occur within the cells, tissues, or an organism. These processes include both the biosynthesis (ANABOLISM) and the breakdown (CATABOLISM) of organic materials utilized by the living organism.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Each mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP. They contain distinctive RIBOSOMES, transfer RNAs (RNA, TRANSFER); AMINO ACYL T RNA SYNTHETASES; and elongation and termination factors. Mitochondria depend upon genes within the nucleus of the cells in which they reside for many essential messenger RNAs (RNA, MESSENGER). Mitochondria are believed to have arisen from aerobic bacteria that established a symbiotic relationship with primitive protoeukaryotes. (King & Stansfield, A Dictionary of Genetics, 4th ed)
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
A human liver tumor cell line used to study a variety of liver-specific metabolic functions.
A 30-kDa COMPLEMENT C1Q-related protein, the most abundant gene product secreted by FAT CELLS of the white ADIPOSE TISSUE. Adiponectin modulates several physiological processes, such as metabolism of GLUCOSE and FATTY ACIDS, and immune responses. Decreased plasma adiponectin levels are associated with INSULIN RESISTANCE; TYPE 2 DIABETES MELLITUS; OBESITY; and ATHEROSCLEROSIS.
An indicator of body density as determined by the relationship of BODY WEIGHT to BODY HEIGHT. BMI=weight (kg)/height squared (m2). BMI correlates with body fat (ADIPOSE TISSUE). Their relationship varies with age and gender. For adults, BMI falls into these categories: below 18.5 (underweight); 18.5-24.9 (normal); 25.0-29.9 (overweight); 30.0 and above (obese). (National Center for Health Statistics, Centers for Disease Control and Prevention)
Fats present in food, especially in animal products such as meat, meat products, butter, ghee. They are present in lower amounts in nuts, seeds, and avocados.
A class of membrane lipids that have a polar head and two nonpolar tails. They are composed of one molecule of the long-chain amino alcohol sphingosine (4-sphingenine) or one of its derivatives, one molecule of a long-chain acid, a polar head alcohol and sometimes phosphoric acid in diester linkage at the polar head group. (Lehninger et al, Principles of Biochemistry, 2nd ed)
A low-affinity 11 beta-hydroxysteroid dehydrogenase found in a variety of tissues, most notably in LIVER; LUNG; ADIPOSE TISSUE; vascular tissue; OVARY; and the CENTRAL NERVOUS SYSTEM. The enzyme acts reversibly and can use either NAD or NADP as cofactors.
Fat cells with dark coloration due to the densely packed MITOCHONDRIA. They contain numerous small lipid droplets or vacuoles. Their stored lipids can be converted directly to energy as heat by the mitochondria.
A type of pancreatic cell representing about 50-80% of the islet cells. Beta cells secrete INSULIN.
A 16-kDa peptide hormone secreted from WHITE ADIPOCYTES. Leptin serves as a feedback signal from fat cells to the CENTRAL NERVOUS SYSTEM in regulation of food intake, energy balance, and fat storage.
Diseases caused by abnormal function of the MITOCHONDRIA. They may be caused by mutations, acquired or inherited, in mitochondrial DNA or in nuclear genes that code for mitochondrial components. They may also be the result of acquired mitochondria dysfunction due to adverse effects of drugs, infections, or other environmental causes.
The failure of a FETUS to attain its expected FETAL GROWTH at any GESTATIONAL AGE.
A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)
A genetic process by which the adult organism is realized via mechanisms that lead to the restriction in the possible fates of cells, eventually leading to their differentiated state. Mechanisms involved cause heritable changes to cells without changes to DNA sequence such as DNA METHYLATION; HISTONE modification; DNA REPLICATION TIMING; NUCLEOSOME positioning; and heterochromatization which result in selective gene expression or repression.
A condition of having excess fat in the abdomen. Abdominal obesity is typically defined as waist circumferences of 40 inches or more in men and 35 inches or more in women. Abdominal obesity raises the risk of developing disorders, such as diabetes, hypertension and METABOLIC SYNDROME X.
Treatments with drugs which interact with or block synthesis of specific cellular components characteristic of the individual's disease in order to stop or interrupt the specific biochemical dysfunction involved in progression of the disease.
Salts and esters of the 16-carbon saturated monocarboxylic acid--palmitic acid.
Substances which lower blood glucose levels.
Abstaining from all food.
A thermogenic form of adipose tissue composed of BROWN ADIPOCYTES. It is found in newborns of many species including humans, and in hibernating mammals. Brown fat is richly vascularized, innervated, and densely packed with MITOCHONDRIA which can generate heat directly from the stored lipids.
Proteins encoded by the mitochondrial genome or proteins encoded by the nuclear genome that are imported to and resident in the MITOCHONDRIA.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
An enzyme that catalyzes the phosphorylation of AMP to ADP in the presence of ATP or inorganic triphosphate. EC
A pathological state in which BLOOD GLUCOSE level is less than approximately 140 mg/100 ml of PLASMA at fasting, and above approximately 200 mg/100 ml plasma at 30-, 60-, or 90-minute during a GLUCOSE TOLERANCE TEST. This condition is seen frequently in DIABETES MELLITUS, but also occurs with other diseases and MALNUTRITION.
Agents that increase energy expenditure and weight loss by neural and chemical regulation. Beta-adrenergic agents and serotoninergic drugs have been experimentally used in patients with non-insulin dependent diabetes mellitus (NIDDM) to treat obesity.
The main structural component of the LIVER. They are specialized EPITHELIAL CELLS that are organized into interconnected plates called lobules.
A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA.
Generally refers to the digestive structures stretching from the MOUTH to ANUS, but does not include the accessory glandular organs (LIVER; BILIARY TRACT; PANCREAS).
An enzyme, sometimes called GGT, with a key role in the synthesis and degradation of GLUTATHIONE; (GSH, a tripeptide that protects cells from many toxins). It catalyzes the transfer of the gamma-glutamyl moiety to an acceptor amino acid.
The relative amounts of various components in the body, such as percentage of body fat.
Ventral part of the DIENCEPHALON extending from the region of the OPTIC CHIASM to the caudal border of the MAMMILLARY BODIES and forming the inferior and lateral walls of the THIRD VENTRICLE.
A broad category of receptor-like proteins that may play a role in transcriptional-regulation in the CELL NUCLEUS. Many of these proteins are similar in structure to known NUCLEAR RECEPTORS but appear to lack a functional ligand-binding domain, while in other cases the specific ligands have yet to be identified.
The dynamic collection of metabolites which represent a cell's or organism's net metabolic response to current conditions.
The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.
A nuclear transcription factor. Heterodimerization with RETINOID X RECEPTOR GAMMA is important to metabolism of LIPIDS. It is the target of FIBRATES to control HYPERLIPIDEMIAS.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
Pathological processes of the LIVER.
Increase in BODY WEIGHT over existing weight.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
A sterol regulatory element binding protein that regulates expression of GENES involved in FATTY ACIDS metabolism and LIPOGENESIS. Two major isoforms of the protein exist due to ALTERNATIVE SPLICING.
Abnormally high BLOOD GLUCOSE level.
Conditions with excess LIPIDS in the blood.
The technique that deals with the measurement of the size, weight, and proportions of the human or other primate body.
Steroid acids and salts. The primary bile acids are derived from cholesterol in the liver and usually conjugated with glycine or taurine. The secondary bile acids are further modified by bacteria in the intestine. They play an important role in the digestion and absorption of fat. They have also been used pharmacologically, especially in the treatment of gallstones.
The section of the alimentary canal from the STOMACH to the ANAL CANAL. It includes the LARGE INTESTINE and SMALL INTESTINE.
Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing.
An imbalanced nutritional status resulted from insufficient intake of nutrients to meet normal physiological requirement.
Mitochondria of skeletal and smooth muscle. It does not include myocardial mitochondria for which MITOCHONDRIA, HEART is available.
Diet modification and physical exercise to improve the ability of animals to perform physical activities.
A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).
Cellular processes in biosynthesis (anabolism) and degradation (catabolism) of CARBOHYDRATES.

Viral gene delivery selectively restores feeding and prevents lethality of dopamine-deficient mice. (1/1017)

Dopamine-deficient mice (DA-/- ), lacking tyrosine hydroxylase (TH) in dopaminergic neurons, become hypoactive and aphagic and die by 4 weeks of age. They are rescued by daily treatment with L-3,4-dihydroxyphenylalanine (L-DOPA); each dose restores dopamine (DA) and feeding for less than 24 hr. Recombinant adeno-associated viruses expressing human TH or GTP cyclohydrolase 1 (GTPCH1) were injected into the striatum of DA-/- mice. Bilateral coinjection of both viruses restored feeding behavior for several months. However, locomotor activity and coordination were partially improved. A virus expressing only TH was less effective, and one expressing GTPCH1 alone was ineffective. TH immunoreactivity and DA were detected in the ventral striatum and adjacent posterior regions of rescued mice, suggesting that these regions mediate a critical DA-dependent aspect of feeding behavior.  (+info)

Human molybdopterin synthase gene: genomic structure and mutations in molybdenum cofactor deficiency type B. (2/1017)

Biosynthesis of the molybdenum cofactor (MoCo) can be divided into (1) the formation of a precursor and (2) the latter's subsequent conversion, by molybdopterin synthase, into the organic moiety of MoCo. These two steps are reflected by the complementation groups A and B and the two formally distinguished types of MoCo deficiency that have an identical phenotype. Both types of MoCo deficiency result in a pleiotropic loss of all molybdoenzyme activities and cause severe neurological damage. MOCS1 is defective in patients with group A deficiency and has been shown to encode two enzymes for early synthesis via a bicistronic transcript with two consecutive open reading frames (ORFs). MOCS2 encodes the small and large subunits of molybdopterin synthase via a single transcript with two overlapping reading frames. This gene was mapped to 5q and comprises seven exons. The coding sequence and all splice site-junction sequences were screened for mutations, in MoCo-deficient patients in whom a previous search for MOCS1 mutations had been negative. In seven of the eight patients whom we investigated, we identified MOCS2 mutations that, by their nature, are most likely responsible for the deficiency. Three different frameshift mutations were observed, with one of them found on 7 of 14 identified alleles. Furthermore, a start-codon mutation and a missense mutation of a highly conserved amino acid residue were found. The locations of the mutations confirm the functional role of both ORFs. One of the patients with identified MOCS2 mutations had been classified as type B, in complementation studies. These findings support the hypothetical mechanism, for both forms of MoCo deficiency, that formerly had been established by cell-culture experiments.  (+info)

Does a high peritoneal transport rate reflect a state of chronic inflammation? (3/1017)

OBJECTIVE: It has recently been reported that a high peritoneal transport rate was associated with increased mortality in continuous ambulatory peritoneal dialysis (CAPD) patients. One possible explanation is that a high peritoneal transport rate might be caused by a state of chronic inflammation, which also per se might result in increased mortality. Therefore, in this study we investigated whether high peritoneal transport rate patients are in a state of chronic inflammation. METHODS: The study included 39 clinically stable peritoneal dialysis patients (free of peritonitis) who had been on PD for more than 3 months (16.8+/-11.8 months). Seven patients were treated with continuous cycling peritoneal dialysis (CCPD) and the others were on CAPD. A 4-hour standard peritoneal equilibration test (PET) using 2.27% glucose solution was performed in each patient. Dialysate samples at 4 hours and blood samples at 2 hours were measured for interleukin-1beta (IL-1beta), tumor necrosis factor(alpha)(TNFalpha), C-reactive protein (CRP), and hyaluronan as markers of inflammation. RESULTS: There was no significant correlation between dialysate/plasma (DIP) creatinine (0.82+/-0.15, range 0.51 - 1.15) and blood concentrations of IL-1beta (11.2 ng/L, range <5 - 65.9 ng/L),TNFalpha (12.1 ng/L, range <5 - 85.4 ng/L), CRP (<10 mg/L, range <10 - 76 mg/L), nor with the blood hyaluronan concentration (165 microg/L, range 55 - 955 microg/L). The dialysate concentrations of IL-1beta and TNFalpha were below the detectable level in most of the samples. Although dialysate hyaluronan concentration (334 microg/L, range 89 - 1100 microg/L) was correlated with D/P creatinine (r= 0.36, p< 0.05), there was no correlation between the total amount of hyaluronan in the effluent and D/P creatinine. However, a significant correlation was found between serum hyaluronan concentration and glomerular filtration rate (GFR) (r = -0.49, p< 0.005); GFR also tended to be correlated with serum TNFalpha (r = -0.31, p = 0.058) but not with serum IL-1beta and serum CRP. CONCLUSION: Our results suggest that a high peritoneal transport rate is not necessarily related to a state of chronic inflammation in CAPD patients. The high mortality rate observed in high transporters may relate to other issues, such as fluid balance or abnormal nutrition and metabolism, rather than to chronic inflammation.  (+info)

Acute symptomatic seizures - incidence and etiological spectrum: a hospital-based study from South India. (4/1017)

We analysed the incidence and etiological spectrum of acute symptomatic seizures in 2531 patients with seizure disorder, both in-patients and out-patients, seen in a university hospital in South India. Seizure(s) occurred in close temporal association with an acute systemic, metabolic, or toxic insult or in association with an acute central nervous system (CNS) insult in 22.5% of patients. Of the 572 patients, 8% could be grouped under the International League Against Epilepsy (ILAE) category 4.1 and 92% under category 1.2. The seizure type was generalized in all the patients included in category 4.1 and 78% of patients grouped in category 2.1 had simple or complex partial seizure(s) with or without secondary generalization. Sixteen (3%) patients developed status epilepticus during the acute phase of illness and 7% of patients had only single seizure. Infections of the central nervous system (CNS) and single CT enhancing lesions (SCTEL) together accounted for 77% of the provoking factors in patients grouped under category 2.1. These two etiological factors together accounted for 95% of etiologies in patients aged under 16 years. SCTEL and neurocysticercosis together accounted for 67% of the provoking factors. In 14% of patients cerebrovascular diseases were the etiological factors and 60% of the patients were aged over 40 years. In patients with cerebrovascular diseases, aged under 40 years, cortical sinovenous thrombosis accounted for 37%. SCTEL was the provoking factor in 61% of patients with isolated seizure. Infections of CNS and SCTEL together accounted for 62.5% of etiological factors for status epilepticus. This study illustrates that the etiological spectrum of acute symptomatic seizures in this part of the world is different from that described from developed countries and CNS infections account for a significant number of cases.  (+info)

Hypermetabolism in clinically stable patients with liver cirrhosis. (5/1017)

BACKGROUND: Hypermetabolism has a negative effect on prognosis in patients with liver cirrhosis. Its exact prevalence and associations with clinical data, the nutritional state, and beta-adrenergic activity are unclear. OBJECTIVE: We investigated resting energy expenditure (REE) in 473 patients with biopsy-proven liver cirrhosis. DESIGN: This was a cross-sectional study with a controlled intervention (beta-blockade) in a subgroup of patients. RESULTS: Mean REE was 7.12 +/- 1.34 MJ/d and correlated closely with predicted values (r = 0.70, P < 0.0001). Hypermetabolism was seen in 160 patients with cirrhosis (33.8% of the study population). REE was > 30% above the predicted value in 41% of the hypermetabolic patients with cirrhosis. Hypermetabolism had no association with clinical or biochemical data on liver function. REE correlated with total body potassium content (TBP; r = 0.49, P < 0.0001). Hypermetabolic patients had lower than normal body weight and TBP (P < 0.05). About 47% of the variance in REE could be explained by body composition whereas clinical state could maximally explain 3%. Plasma epinephrine and norepinephrine concentrations were elevated in hypermetabolic cirrhotic patients (by 56% and 41%, respectively; P < 0.001 and 0.01). Differences in REE from predicted values were positively correlated with epinephrine concentration (r = 0.462, P < 0.001). Propranolol infusion resulted in a decrease in energy expenditure (by 5 +/- 3%; P < 0.05), heart rate (by 13 +/- 4%; P < 0.01), and plasma lactate concentrations (by 32 +/- 12%; P < 0.01); these effects were more pronounced in hypermetabolic patients (by 50%, 33%, and 68%, respectively; each P < 0.05). CONCLUSIONS: Hypermetabolism has no association with clinical data and thus is an extrahepatic manifestation of liver disease. Increased beta-adrenergic activity may explain approximately 25% of hypermetabolism.  (+info)

Effect on cytokine release and graft-versus-host disease of different anti-T cell antibodies during conditioning for unrelated haematopoietic stem cell transplantation. (6/1017)

Three different types of anti-T cell antibody were used in patients undergoing haematopoietic stem cell transplantation (HSCT) with an HLA-A, -B and -DR compatible unrelated donor: ATG-Fresenius (ATG-F) (n = 26), Thymoglobuline (TMG) (n = 61) and OKT-3 (n = 45). The groups were comparable regarding diagnosis, stage, age, conditioning and GVHD prophylaxis, Adverse events were less frequent after ATG-F treatment. Levels of IL-2, IL-6, IFN-gamma, TNF-alpha and GM-CSF were increased after OKT-3 infusion. In multivariate analysis OKT-3 treatment (P = 0.01), G-CSF treatment (P = 0.02) and a cell dose >/=2.7 x 108/kg (P = 0.03) gave a faster engraftment. Acute GVHD grades II-IV occurred in 25% of the ATG-F patients, 12% of the TMG-patients and 43% (P < 0.001 vs TMG) of the OKT-3 patients. OKT-3 was associated with acute GVHD in multivariate analysis. TRM was 26% using TMG as compared to 43% in the OKT-3 group (P = 0.03). Patient survival at 4 years was 63%, 50% and 45% in the ATG-F, TMG and OKT-3-treated patients, respectively (NS). Relapses were 8%, 49% and 34%, respectively (ATG-F vs TMG, P = 0.03). Relapse-free survivals were 61%, 40% and 37% (NS). Among CML patients the probability of relapse was 61% in TMG-treated patients, while no patients relapsed in the other two groups. To conclude, the type of anti-T cell antibody affects GVHD and relapse after HSCT using unrelated donors.  (+info)

Itraconazole oral solution as antifungal prophylaxis in children undergoing stem cell transplantation or intensive chemotherapy for haematological disorders. (7/1017)

This was an open study of oral antifungal prophylaxis in 103 neutropenic children aged 0-14 (median 5) years. Most (90%) were undergoing transplantation for haematological conditions (77% allogeneic BMT, 7% autologous BMT, 6% PBSC transplants and 10% chemotherapy alone). They received 5.0 mg/kg itraconazole/day (in 10 mg/ml cyclodextrin solution). Where possible, prophylaxis was started at least 7 days before the onset of neutropenia and continued until neutrophil recovery. Of the 103 who entered the study, 47 completed the course of prophylaxis, 27 withdrew because of poor compliance, 19 because of adverse events and 10 for other reasons. Two patients died during the study and another five died within the subsequent 30 days. No proven systemic fungal infections occurred, but 26 patients received i.v. amphotericin for antibiotic-unresponsive pyrexia. One patient received amphotericin for mycologically confirmed oesophageal candidosis. Three patients developed suspected oral candidosis but none was mycologically proven and no treatment was given. Serious adverse events (other than death) occurred in 21 patients, including convulsions (7), suspected drug interactions (6), abdominal pain (4) and constipation (4). The most common adverse events considered definitely or possibly related to itraconazole were vomiting (12), abnormal liver function (5) and abdominal pain (3). Tolerability of study medication at end-point was rated as good (55%), moderate (11%), poor (17%) or unacceptable (17%). Some patients had poor oral intakes due to mucositis. No unexpected problems of safety or tolerability were encountered. We conclude that itraconazole oral solution may be used as antifungal prophylaxis for neutropenic children.  (+info)

Adverse metabolic disorders during highly active antiretroviral treatments (HAART) of HIV disease. (8/1017)

Protease inhibitor treatment has dramatically improved rates of morbidity and mortality in HIV-infected patients. However, it has recently been shown that this medication is associated with long-term side effects characterized by metabolic, clinical and biological alterations. These modifications have been described in patients treated with highly active antiretroviral therapy (HAART), including nucleoside analogue reverse transcriptase inhibitors (NRTI) and generally (but not always) protease inhibitors (PI). Clinical alterations are characterised by a body fat redistribution syndrome or lipodystrophy, with peripheral lipoatrophy and/or central fat accumulation. They are often associated with biological alterations, i.e. insulin resistance, hyperglycaemia and dyslipidaemia, which can also be observed alone. The pathophysiology of these alterations is presently unknown. The deleterious effect of PI on adipose tissue could be direct or indirect, and is probably modulated by genetic or environmental factors. NRTI could also be involved because of their mitochondrial toxicity. The purpose of the treatment is to control metabolic disturbances in order to prevent immediate complications such as acute pancreatitis and limit possible cardiovascular and diabetic complications at longer term. Studies are in progress to evaluate the possibility of therapeutic alternatives to PI when major metabolic disturbances are present.  (+info)

This team focuses its research on cellular and systemic lipid and lipoprotein metabolism which opens up new insights based its recent pioneer works on the identification by Omic approaches of lipid networks controlling biological activities of atheroprotective HDL and cell activation in cardiometabolic diseases. In the last few years, this team has developed translational approaches and new analytic tools for proposing new candidate genes and biomarkers with a high potential of patentability in the context of cardiometabolic diseases.. This team is attached to the doctorale school 394 Physiologie, Physiopathologie et Thérapeutique.. ...
Headline: Bitcoin & Blockchain Searches Exceed Trump! Blockchain Stocks Are Next!. adds a new research report Global Metabolic Disorders Therapeutics Market 2016-2020. The report, Global Metabolic Disorders Therapeutics Market 2016-2020, has been prepared based on an in-depth market analysis with inputs from industry experts. This report covers the market landscape and its growth prospects over the coming years. The report also includes a discussion of the key vendors operating in this market.. This analyst forecast the global metabolic disorders therapeutics market to grow at a CAGR of 4.62% during the period 2016-2020.. Complete report available @ Metabolic disorders occur as a result of disruption of chemical processes and conversions occurring in the cells and fluids of the body. This is mainly because of defects in the enzyme; all process in the body are ...
Friday, April 26, 2013 Researchers at the University of Maryland School of Medicine, Baltimore, have shown in a mouse model that infection with nematodes (also known as roundworms) can not only combat obesity but ameliorate related metabolic disorders. Their research is published ahead of print online in the journal Infection and Immunity.. Gastrointestinal nematodes infect approximately 2 billion people worldwide, and some researchers believe up until the 20th century almost everyone had worms. In developed countries there is a decreasing incidence of nematode infection but a rising prevalence of certain types of autoimmunity, suggesting a relationship between the two. Nematode infection has been purported to have therapeutic effects and currently clinical trials are underway to examine worms as a treatment for diseases associated with the relevant cytokines, including inflammatory bowel disease, multiple sclerosis, and allergies.. In the study researchers tested the effect of nematode ...
Metabolic diseases continue to rise in global prevalence. Although there is evidence that current methods of treatment are effective, the continued rise in prevalence indicates that alternative, more efficient treatment options are needed. Over the last several years, immune cells have been increasingly studied as important players in the development of a range of diseases, including metabolic diseases such as obesity and obesity-induced type 2 diabetes. This review explores how understanding the intrinsic metabolism of innate-like T cells could provide potential targets for treating metabolic disease, and highlights research areas needed to advance this promising therapeutic approach.
The Diabetes and Cardiometabolic Disease Clinical Topic Collection gathers the latest guidelines, news, JACC articles, education, meetings and clinical images pertaining to its cardiovascular topical area - all in one place for your convenience.
How is National Institute of Arthritis and Metabolic Diseases abbreviated? NIAMD stands for National Institute of Arthritis and Metabolic Diseases. NIAMD is defined as National Institute of Arthritis and Metabolic Diseases somewhat frequently.
Next friday 6th September, Dr. Samia Mora, from the Brigham and Womens Hospital, Boston going to talk about Lipoprotein Predictors of Cardiometabolic Disease.. Session will be hold at 11h at Sala Polivalent of the Centre for Omic Sciences.. More information here. ...
The prevalence of diet-induced metabolic diseases, including insulin resistance, type 2 diabetes, hypertension, cardiovascular disease, fatty liver disease, and metabolic syndrome, is rising rapidly worldwide, with obesity representing a central risk factor [1]. Moreover, obesity enhances the likelihood of developing numerous blood borne and solid cancers, thus undoubtedly increasing morbidity and mortality in an unprecedented manner [2]. The pathogenesis of those metabolic diseases that are triggered by excessive caloric intake remains to be fully elucidated, although researchers have recently highlighted that organ and systemic damage associated with these pathologies might be the result of a complex network of interactions between genetics and environment, potentially orchestrated by epigenetic mechanisms [3]. The eukaryotic epigenome is postulated to interact with environmental stimuli through alterations of several chromatin features, and by differential silencing or activation of gene expression.
Diabetes, metabolic syndrome and dyslipidemia are common and rapidly increasing in Asia. Our group constructed a cohort in Chung-ju city, a rural area in Korea, to observe the prevalence of metabolic diseases and its risk factors since 2003. About 12,000 subjects participated in this cohort study till 2006. Now, we are planning to follow-up these subjects and provide health examinations from May, 2007 to Feb, 2011. The prevalence and incidence of metabolic diseases including diabetes, hypertension, metabolic syndrome, dislipidemia and osteoporosis will be observed ...
Function of Collagens in Energy Metabolism and Metabolic Diseases | Open Access | OMICS Publishing Group This article shows a link between collagen production and energy problems associated with Metabolic Diseases. Could this be a new avenue of research? Defining the cellular sources of collagens in the normal and diseased states of the above metabolic…
Chronic inflammation of tissues is thought to cause obesity and metabolic disease, but a new research has found how healthy inflammation could actually prevent metabolic disease
Despite scientific advancements, cardiovascular disease remains the number one cause of death globally, with high residual risk of recurrent events.1,2 A growing body of scientific evidence is uncovering the clinical overlap between cardiovascular, renal and metabolic diseases (CVMD) and their associated complications, which helps explain why reducing cardiovascular risk is so complex - yet in many cases, each condition is managed in isolation. With this growing unmet need in mind, we have developed a distinct approach at AstraZeneca focusing on jointly addressing patients cardio-renal-metabolic risks to change the science and treatment landscape.. Our team is proud of the breadth of AstraZeneca early- to late-stage data across cardiovascular, renal and metabolic diseases that is being presented at the upcoming American Society of Nephrology (ASN) Kidney Week 2017. We will be presenting 33 abstracts investigating anaemia, hyperkalaemia and diabetic kidney disease, among other CVMD conditions ...
TY - JOUR. T1 - Multifunctional p62 Effects Underlie Diverse Metabolic Diseases. AU - Long, Min. AU - Li, Xing. AU - Li, Li. AU - Dodson, Matthew. AU - Zhang, Donna. AU - Zheng, Hongting. PY - 2017. Y1 - 2017. N2 - p62, a protein capable of binding both ubiquitin and autophagy substrates, is well established as a key regulator in cancer and neurodegenerative diseases. Recently, there has been accumulating evidence that p62 is also a pivotal regulator in metabolic diseases, such as obesity, T2DM, NAFLD, metabolic bone disease, gout and thyroid disease. This review summarizes the emerging role of p62 on these diseases by considering its functional domains, phenotypes in genetically modified animals, clinically observed alterations, and its effects on downstream metabolic signaling pathways. At the same time, we highlight the need to explore the roles played by p62 in the gastrointestinal environment and immune system, and the extent to which its elevated expression may confer protection against ...
AN OPPORTUNITY to establish screening procedures for case-finding in a number of metabolic diseases now exists in the United States, because most infants are born in hospitals where appropriate screening can easily be carried out. Case-finding in the neonatal period facilitates early inauguration of therapy, genetic counseling, and improved understanding of the natural history and incidence of metabolic diseases.. The Committee on Fetus and Newborn considered four types of screening programs: (1) screening of all newborn infants, (2) screening of specific groups of neonates with increased risk of certain disorders, (3) large scale, pilot-screening programs, designed primarily for research and acquisition of knowledge about the natural history of disease, (4) screening of expectant mothers, particularly using tests of amniotic fluid.. The committee did not consider screening of older children. However, it is emphasized that a number of important diseases, e.g., Wilsons disease, cannot be ...
Metabolic diseases such as diabetes, steatohepatitis, and coronary artery disease result from the delivery of nutrients that exceed a tissues energetic needs or storage capacity. The excess nutrients give rise to deleterious lipid species that impair cellular function. Summers and colleagues found that ceramides, a class of sphingolipids, alter the metabolism of liver and adipose tissue in a way that gives rise to cardiometabolic disease. Continue reading → Lipid Metabolism and Cardiometabolic Disease ...
The intention has been to provide a simple guide to the interrelationships between nutrition, physiology and metabolic disorders. Metabolic Diseases in Farm
How to Diagnose Metabolic Disease in Older Dogs. Like people, dogs develop a variety of metabolic disorders as they age. Unfortunately, since dogs are unable to communicate like people, their ailments go untreated until symptoms are...
The latest Financial Conduct Authority thematic review, published on 31 October, provides an assessment of the Anti-Money Laundering and Anti-Bribery and Corruption systems and controls across asset management and platform firms. UK Finance and Banking Deloitte 11 Nov 2013
The role of chronic inflammation in the pathogenesis of type 2 diabetes mellitus and associated complications is now well established. Therapeutic interventions counteracting metabolic inflammation improve insulin secretion and action, glucose control, and may prevent long-term complications. Thus, a number of anti-inflammatory drugs approved for the treatment of other inflammatory conditions are evaluated in patients with metabolic syndrome.. Most advanced are clinical studies with interleukin-1 antagonists showing improved β-cell function and glycemia, prevention of cardiovascular diseases, and heart failure. However, alternative anti-inflammatory treatments, alone or in combinations, may turn out to be more effective, depending on genetic predispositions, duration, and manifestation of the disease. Thus, there is a great need for comprehensive and well-designed clinical studies to implement anti-inflammatory drugs in the treatment of patients with metabolic syndrome and its associated ...
The prevalence of asthma and cardiovascular disease and metabolic disease in people with severe asthma is primarily determined by their individual risk factors, such as age, hypertension, obesity, and cigarette smoke exposure.
The mission of the Boshell Diabetes and Metabolic Diseases Research Program is to enhance the opportunities for diabetes research at Auburn University by facilitating cross-disciplinary scientific discussion, supporting the study of new ideas, fostering the development of scientists new to the field of diabetes, and expanding, the overall base of diabetes investigation at the university. more ...
Semantic Scholar extracted view of [Dental treatment in patients with metabolic diseases, especially diabetes mellitus]. by Taisuke Yoshimi et al.
Description: Generic term for diseases caused by an abnormal metabolic process. It can be congenital due to inherited enzyme abnormality (METABOLISM, INBORN ERRORS) or acquired due to disease of an endocrine organ or failure of a metabolically important organ such as the liver. (Stedman, 26th ed ...
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Pilot and Feasibility Clinical Trials in Diabetes, and Endocrine and Metabolic Diseases (R21) PA-15-176. NIDDK
Sugar is shamed as the #1 risk factor for cardiovascular disease, but studies point elsewhere. Get the bigger picture on diet, obesity, and CVD.
Aim: There remains high unmet medical need for therapies to treat cardio/metabolic diseases. We validated in human trials, a platform for reducing the synthesis of genes expressed in the liver. The platform utilizes a GalNAc ligand attached to the 3 end of the sense strand of an RNAi molecule to enable delivery specifically to the liver. Here we extend the platform to targets of interest in cardiovascular disease, including PCSK9, ANGPLT3 and ApoC3.. METHODS: Chemically modified siRNAs were designed and were screened for potency in vitro. pM active siRNA molecules were developed targeting PCSK9, ANGPLT3 and ApoC3. The siRNAs were tested in either rodents or in non-human primates (NHPs) for activity.. RESULTS: In NHPs a single dose of ALN-PCSsc at 6 mg/kg reduced PCSK9 levels up to 97% and LDL-C up to 67%. Moreover the nadir effect (without any rebound of LDL-C) lasted ,30 days indicating that once a month or longer dosing frequency in clinic should be supported. Multidose studies in NHP at ...
Wiley. The first question cancer victims may ask is, Why did I get cancer? The answer is usually sympathetic silence. There is still no concrete answer. In the U.S., cancer is becoming the number-one cause of death. Researchers are far from finding a cure, despite the War on Cancer and billions of dollars of research money poured into labs around the country since 1971. The majority of cancer deaths (90 percent) are the result of metastasis, or spread of cancer, yet most research does not involve metastasis and much of what is known comes from cells that have more in common with non-cancerous tumors than with metastatic ones.. In his groundbreaking book, Cancer as a Metabolic Disease, which is supported by evidence from more than one thousand scientific and clinical studies, Thomas Seyfried, PhD, explains the ins and outs of cancer development, how it metastasizes, where it goes and why. Dr. Seyfried is a professor of biology at Boston College who has conducted research on such topics as ...
TY - CHAP. T1 - Metabolic disorders. AU - Edelmann, Lisa. AU - Yang, Yaping. AU - Yang, Amy. AU - Kornreich, Ruth. PY - 2016/1/1. Y1 - 2016/1/1. N2 - Inborn errors of metabolism represent a highly diverse group of genetic disorders. Although individually the disorders are rare, collectively they are estimated to affect as many as 1 in 600 individuals. This chapter discusses the molecular mechanisms of disease and the available genetic testing for selected metabolic disorders. Mutations in many of the metabolic diseases are genetically heterogeneous and diagnoses are still widely dependent on biochemical testing. DNA testing is critical for confirmatory studies, genetic counseling, carrier and prenatal testing, and genotype-phenotype correlation, and is widely used for carrier screening for metabolic disorders in certain populations that have a high frequency of specific mutations due to founder effects. With increasing use of next-generation sequencing technologies in the clinical laboratory, ...
Metabolic Diseases, Biological Mechanisms of - CHEMICAL BIOLOGY - reflects the multidimensional character of chemical biology, focusing in particular on the fundamental science of biological structures and systems, the use of chemical and biological techniques to elucidate
Cardiovascular, renal and metabolic diseases are inextricably linked and are the leading causes of mortality and morbidity in the United States, especially in M...
Posted on the Department of Health website, National Metabolic Disease Awareness Week highlights the urgent need to recognize this significant group of medical conditions, which often first appear in childhood and cause more disability and deaths in that age group than cancer.
Cancer is a metabolic disease, not a genetic one. As long as your mitochondria remain healthy and functional, your chances of developing cancer are slim.
ABSTRACT Adaptive responses that counter starvation have evolved over millennia to permit organismal survival, including changes at the level of individual organelles, cells, tissues, and organ systems
Jess: Ethans Story. This week is Metabolic Disorders Awareness Week so I am going to share a little - however even finding a profile picture of my little boy Ethan to raise awareness is extremely tough. I dont want to show pictures of him on a life support machine, I want to share pictures of him smiling and happy. I miss him every day and having Climb as a support network really helps me with my grieving some days.. Metabolic disorders arent always easy to spot in a person. You can look perfectly normal and your body on the inside is struggling to break down what it needs to break down in order for you to be healthy. These disorders are sometimes blind to see and there are even children and adults out there with metabolic disorders who dont even know they have one. When I had my son I learnt genetics. I learnt how my little boy couldnt break down protein in his body so he had to have drugs to do it for him. I learnt that if these proteins werent escaping his body he would be at risk of ...
Fasting can help you control your food intake without having to count calories. In a study published in the International Journal of Obesity and Related Metabolic Disorders, researchers observed how volunteers ate after a 36-hour fast.. The participants consumed slightly more calories at their next meal compared to those who didnt fast. However, the results revealed that those who fasted consumed at least 2,000 fewer calories within the next two days.. Dont assume that breaking a fast is the same as an invitation to binge-eat. If you eat a lot of high-calorie food, your body tends to store extra calories by forming fat, which delays your fasting results.. ...
The main objective of this study was to elucidate whether sCD93 plays a role in metabolic disease or CVD. Our results refute sCD93 as an important factor in the early vascular changes indicative of atherosclerosis; however, they do provide solid evidence for a role of sCD93 in glucometabolic regulation and a starting point for understanding the role of CD93 in these diseases.. The most striking result from the current study is the finding that reduced levels of sCD93 were associated with metabolic dysregulation. In addition, we show the following: 1) lower sCD93 levels were observed in subjects with T2D who had high CVD risk than in those subjects without T2D; 2) insulin-related processes were associated with sCD93 levels in subjects without diabetes; 3) lower levels of sCD93 were not due to genetic susceptibility to T2D; 4) lower sCD93 levels precede the development of T2D; 5) dietary stress in a cd93-deficient mouse model caused impaired metabolic regulation and increased endothelial damage; ...
We are the Home of the Cancer Profile and Longevity Profile. Testing for early detection, prevention and treatment response of cancer and other metabolic disorders. These are non-invasive, radiation free blood and urine biomarker tests that you can order with or without a doctors order.
Metabolic disorders in patients with diabetes place them at particularly high risk for CV morbidity. Find insights on Dx and Tx in these slides.
Concentrates on dyslipidemia, atherosclerosis and vascular diseases, type 2 diabetes, heart failure, cardiac arrhythmias and associated disorders.
SuperCoder is powered by the experienced coding and compliance professionals at TCI. TCIs vision is to deliver innovative healthcare solutions and knowledge to our customers worldwide ...
31050 Monastier di Treviso. Aims The 22nd Meeting of the ECCR focused on recent advances in hypertension and cardiometabolic disease with an emphasis on translational research from discovery science to human disease.. Highlights of the 22nd Meeting. ...
Our protein biology products such as Peptide Synthesis and Elisa Kits allow you to detect, measure, and explore a protein expressions identity and function
I know I just published my review of Cancer as a Metabolic Disease, but I stumbled across some news that I thought was worth relating.. One of the most beautifully written and compelling parts of Seyfrieds exhaustive hypothesis is the idea that metastasis is too complex of a process to be accounted for by random genetic mutation. The idea that many different types of cancer cells would all somehow collect the right genetic mutations that would make them able to enter and exit tissues, evade detection by the immune system, and spread throughout the body seems ludicrous. From the very beginnings of Cancer as a Metabolic Disease, Seyfried begins to question this and show how the process of metastasis involves abilities already present in some macrophages and leukocytes ...
The brains and bodies of young female rats can be accelerated into puberty by the presence of an older male or by stimulation of the genitals.. 1 Comment. ...
My team is growing! Interested in starting a postdoc studying cardiometabolic disease in a dynamic and inspiring scientific environment of highest quality? Check out and apply now! Application deadline 17.11 #postdoc # ...
Bacteria inhabit most tissues in the human body, and genes from some of these microbes have made their way to the human genome. Could this genetic transfer contribute to diseases such as cancer?. 3 Comments. ...
Visit Healthgrades for information on Dr. Luis Gonzalez, MD Find Phone & Address information, medical practice history, affiliated hospitals and more.
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Proper control of metabolism is required for essentially every basic biological process. Altered metabolism can lead to a number of metabolic disorders
Visiongain published the Global Metabolic Disorder Therapeutics market forecast analysis, Plus profiles of Leading companies, national and regional level Trends to 2030
"Diseases - Metabolic Diseases - Causes/Inheritance". Muscular Dystrophy Association. Retrieved 2016-03-02.. ... Hoffmann GF (2002-01-01). Inherited Metabolic Diseases. Lippincott Williams & Wilkins. ISBN 9780781729000.. ... "Glycogen storage disease XI - Conditions - GTR - NCBI". Retrieved 2016-03-02.. ... Mutations of the M subunit have been linked to the rare disease exertional myoglobinuria (see OMIM article), and mutations of ...
A class of metabolic diseases *A class of systemic diseases[2][3] ... Diabetes mellitus - group of metabolic diseases in which a ... Disease of affluence - type 2 diabetes is one of the "diseases of affluence", which include mostly chronic non-communicable ... However, the disease can often be delayed through proper nutrition and regular exercise.[7] ... Type 1 diabetes - disease that results in autoimmune destruction of insulin-producing beta cells of the pancreas.[4] ...
Endocrine, nutritional, and metabolic diseases (E00-E88). *Injury, poisoning and certain other consequences of external causes ... G00-G99 - Diseases of the nervous system[edit]. (G00-G09) Inflammatory diseases of the central nervous system[edit]. *(G00) ... G30) Alzheimer's disease. *(G31) Other degenerative diseases of nervous system, not elsewhere classified *(G31.0) ... G94) Other disorders of brain in diseases classified elsewhere. *(G95) Other diseases of spinal cord *(G95.0) Syringomyelia and ...
Metabolic disease: DNA replication and DNA repair-deficiency disorder. DNA replication. *Separation/initiation: RNASEH2A * ... Li-Fraumeni syndrome, in the National Library of Medicine Genetics Home Reference (an introduction to the disease) ...
MRC Metabolic Diseases Unit (MRC MDU). *MRC Mitochondrial Biology Unit (MRC MBU) ... Centers for Disease Control (CDC) (1991). "Use of folic acid for prevention of spina bifida and other neural tube defects-1983- ... "Liver Study Offers Insights into Hard-to-treat Diseases" (Press release). University of Edinburgh. 9 March 2018. Retrieved 9 ... MRC Centre for Neuromuscular Diseases (based at University College London). *MRC Centre for Outbreak Analysis and Modelling ( ...
Nyhan WL, Hoffmann GF, Barshop BA (30 December 2011). Atlas of Inherited Metabolic Diseases 3E. CRC Press. pp. 141-. ISBN 978-1 ... dihydrofolate metabolic process. • one-carbon metabolic process. • axon regeneration. • regulation of transcription involved in ... folic acid metabolic process. • tetrahydrobiopterin biosynthetic process. • oxidation-reduction process. • regulation of ... tetrahydrofolate metabolic process. • tetrahydrofolate biosynthetic process. • positive regulation of nitric-oxide synthase ...
... one with parathyroid disease and a normal appearance (MEN 2A) and the other without parathyroid disease but with mucosal ... Although not officially categorized as multiple endocrine neoplasia syndromes, Von Hippel-Lindau disease[2] and Carney complex[ ... Inheritance is autosomal dominant; any affected parent has a 50% chance to transmit the disease to his or her progeny. MEN1 ... There is significant intra- and inter-familial variability in the age of onset, severity of disease, and tumor types. Despite ...
Metabolic Disease; and Oncology.[33] In October 2013, AstraZeneca announced it would acquire biotech oncology company Spirogen ... In February 2012, AstraZeneca and Amgen announced a collaboration on treatments for inflammatory diseases.[25] Then in April ... "GEN - News Highlights:Aegerion Snaps Up Rare Disease Drug from AstraZeneca for $325M+". GEN.. ... AstraZeneca and Amgen collaborate on treatments for inflammatory diseases Medcity News, 4 February 2012 ...
Metabolic Brain Disease. 30 (5): 1279-84. doi:10.1007/s11011-015-9672-2. PMID 25920484.. ... Puck JM, Willard HF (January 1998). "X inactivation in females with X-linked disease". The New England Journal of Medicine. 338 ... An extreme case of this was seen where monozygotic female twins had extreme variance in expression of Menkes disease (an X- ... For example, a female heterozygous for haemophilia (an X-linked disease) would have about half of her liver cells functioning ...
Metabolic Brain Disease. 23 (1): 115-22. doi:10.1007/s11011-007-9076-z. PMID 18034292.. ... Metabolic Brain Disease. 14 (1): 1-20. doi:10.1023/A:1020653312697. PMID 10348310.. ... Failure in diagnosis of WE and thus treatment of the disease leads to death in approximately 20% of cases, while 75% are left ... Metabolic Brain Disease. 10 (1): 17-24. doi:10.1007/BF01991779. PMID 7596325.. ...
"Addison's Disease". National Endocrine and Metabolic Diseases Information Service. Retrieved 14 August 2013. "Etiology of ... This may be the result of either previously undiagnosed or untreated Addison's disease, a disease process suddenly affecting ... Adrenal crisis is caused by a deficiency of cortisol resulting from Addison's disease, congenital adrenal hyperplasia (CAH), ... Addison's Disease Self Help Group (ADSHG). Addisonian crisis on ...
... has been linked to Alzheimer's disease as well as other metabolic and vascular diseases.[3] ... Alzheimer's disease[edit]. Based on studies, it is evident that obesity has a strong association with vascular and metabolic ... This parameter has been used in the study of metabolic syndrome[67][68] and cardiovascular disease.[69] ... Poehlman, Eric T. (1998). "Abdominal Obesity: The Metabolic Multi-risk Factor". Coronary Heart Disease. Exp. 9 (8): 469-471. ...
"National Endocrine and Metabolic Diseases Information Service (NEMDIS). July 2008. Retrieved 16 March 2015. These benign, or ... "In Chrousos G. Adrenal physiology and diseases. *^ Tomlinson JW, Walker EA, Bujalska IJ, Draper N, Lavery GG, ... This form of the syndrome, known as Cushing's disease. *^ Forbis P (2005). Stedman's medical eponyms (2nd ed.). Baltimore, Md ... Metabolic response[edit]. In the early fasting state, cortisol stimulates gluconeogenesis (the formation of glucose), and ...
Jakobs, C.; Jaeken, J.; Gibson, K. M. (1993). "Inherited disorders of GABA metabolism". Journal of Inherited Metabolic Disease ... Such diseases are caused by an error in a single DNA gene. Because the disease is autosomal, the defective gene is found on an ... Journal of Inherited Metabolic Disease. 30 (3): 279-294. doi:10.1007/s10545-007-0574-2. PMID 17457693.. ... Ultimately, the metabolic pathway of SSADH deficiency is known, but how the enzyme deficiency and accumulation of GABA and GHB ...
Bosch AM (Aug 2006). "Classical galactosaemia revisited". Journal of Inherited Metabolic Disease. 29 (4): 516-25. doi:10.1007/ ... Decreased expression of ChAT is one of the hallmarks of Alzheimer's disease. Patients with Alzheimer's disease show a 30 to 90 ... The disease is caused by a defect in the gene CPT2. This deficiency will present in patients in one of three ways: lethal ... However, ChAT deficiency is not believed to be the main cause of this disease. Patients with ALS show a marked decrease in ChAT ...
"Journal of Inherited Metabolic Disease. 33 (5): 469-477. doi:10.1007/s10545-010-9061-2. ISSN 0141-8955. PMC 2950079 . PMID ...
Journal of Inherited Metabolic Disease. 10 Suppl 1: 159-200. doi:10.1007/bf01812855. PMID 3119938. Zhang J, Frerman FE, Kim JJ ... Deficiency in ETF dehydrogenase causes the human genetic disease multiple acyl-CoA dehydrogenase deficiency. ETQ-QO links the ... More severe cases involve congenital defects and full metabolic crisis. Genetically, it is an autosomal recessive disorder, ... although due to the varying mutations causing the disease treatment and symptoms can vary considerably. Oxidative ...
"Histidinemia: a benign metabolic disorder". Archives of Disease in Childhood. 74 (4): 343-346. doi:10.1136/adc.74.4.343. PMC ... Histidinemia, is a rare autosomal recessive metabolic disorder caused by a deficiency of the enzyme histidase. Histidase is ...
Stern, William (1 March 2016). "Pride and protein". Journal of Inherited Metabolic Disease. 39 (2): 321-324. doi:10.1007/s10545 ... In 2016, a scientific paper published in the Journal of Inherited Metabolic Diseases speculated that Mrs. Bennet may have been ... a carrier of a rare genetic disease, explaining why the Bennets didn't have any sons, and why some of the Bennet sisters are so ...
Bailey, CJ (2009). "Orotic aciduria and uridine monophosphate synthase: a reappraisal". Journal of Inherited Metabolic Disease ... Major metabolic pathways in metro-style map. Click any text (name of pathway or metabolites) to link to the corresponding ... Defects in purine catabolism can result in a variety of diseases including gout, which stems from an accumulation of uric acid ... Deficiencies of enzymes involved in pyrimidine synthesis can lead to the genetic disease Orotic aciduria which causes excessive ...
Journal of Inherited Metabolic Disease. 33 Suppl 3: S481-7. doi:10.1007/s10545-010-9246-8. PMID 21088898.. ...
Mancini GM, Havelaar AC, Verheijen FW (May 2000). "Lysosomal transport disorders". Journal of Inherited Metabolic Disease. 23 ( ... ATP metabolic process. • cellular amino acid metabolic process. • personal grooming. • L-cystine transport. • transport. • ... glutathione metabolic process. • visual learning. • long-term memory. • brain development. • lens development in camera-type ... Mutations in CTNS are responsible for cystinosis, an autosomal recessive lysosomal storage disease.[5] ...
Journal of Inherited Metabolic Disease. 21 (5): 498-506. doi:10.1023/A:1005458703363. PMID 9728330.. ... The effect usually relates to an enzyme with a crucial function in a metabolic pathway, or to a component of an electron- ... The risk of Parkinson's disease has been shown to increase with occupational exposure to herbicides and pesticides.[36] The ... Gorell, JM; Johnson, CC; Rybicki, BA; Peterson, EL; Richardson, RJ (1998). "The risk of Parkinson's disease with exposure to ...
Metabolic Basis of Inherited Disease. 5th ed. New York: McGraw-Hill, 1983. ... Wernicke's disease is one of the most prevalent neurological or neuropsychiatric diseases.[25] In autopsy series, features of ... R.E. Austic and M.L. Scott, Nutritional deficiency diseases, in Diseases of poultry, ed. by M.S. Hofstad, Iowa State University ... Mortality caused by Wernicke's disease reaches 17% of diseases, which means 3.4/1000 or about 25 million contemporaries.[27][28 ...
Nutrition Management of Inherited Metabolic Diseases: Lessons from Metabolic University. Springer. p. 91. ISBN 9783319146218. ... It was recently suggested that PKU may resemble amyloid diseases, such as Alzheimer's disease and Parkinson's disease, due to ... "Journal of Inherited Metabolic Disease. 33 (6): 671-6. doi:10.1007/s10545-010-9216-1. PMC 2992655. PMID 20976625.. ... summary of recent sessions of the committee of experts to study inborn metabolic diseases". Public Health Committee, Eur. J. ...
Other common causes include metabolic bone diseases (e.g. Paget's disease of bone), post-Perthes deformity, osteomyelitis, and ... Coxa vara is also seen in Niemann-Pick disease. Congenital coxa vara[edit]. Presence at birth is extremely rare and associated ... It is most commonly a sequela of osteogenesis imperfecta, Pagets disease, osteomyelitis, tumour and tumour-like conditions (e.g ...
"Cholesterol-lowering probiotics as potential biotherapeutics for metabolic diseases". Experimental Diabetes Research. 2012: ... Inflammatory bowel disease[edit]. Probiotics are being studied for their potential to influence inflammatory bowel disease. ... Assessment of certain metabolic activities (e.g. D-lactate production, bile salt deconjugation) ... Alvarez-Olmos MI, Oberhelman RA (2001). "Probiotic agents and infectious diseases: a modern perspective on a traditional ...
A Metabolic Disease" (PDF). New York Arch Intern Med -Vol 120.. ...
Metabolic Brain Disease Metab Brain Dis. 30 (5): 1279-284. doi:10.1007/s11011-015-9672-2. CS1 maint: Multiple names: authors ... An extreme case of this was seen where monozygotic female twins had extreme variance in expression of Menkes disease (an X- ... Puck, J; Willard, HF (1998). "X Inactivation in Females with X-Linked Disease". N. Engl. J. Med. 338 (5): 325-8. doi:10.1056/ ... For example, a female heterozygous for haemophilia (an X-linked disease) would have about half of her liver cells functioning ...
Malformations and Diseases Cardiovascular Research The Herbert and Dorothy Nadolny Cardio-Metabolic Diseases Research Hub ... "Metabolic disease". Retrieved 2016-05-03. "The "Microbe Brain Storming Hub" (MIBS)". medicine.ekmd. ... The Kuvin Center for the Study of Infectious and Tropical Diseases; The Brain Disease Research Center - BDRC; The Autism Center ... "Brain Diseases Research Center". Retrieved 2016-05-03. "Autism". Retrieved ...
"Bile acid signaling in metabolic disease and drug therapy". Pharmacol. Rev. 66 (4): 948-83. doi:10.1124/pr.113.008201. PMC ... Bile acids have metabolic actions in the body resembling those of hormones, acting through two specific receptors, the ... Metabolic functionsEdit. Emerging evidence associates FXR activation with alterations in triglyceride metabolism, glucose ... It is commonly found when the ileum is abnormal or has been surgically removed, as in Crohn's disease, or cause a condition ...
Cody, J. D. (1 December 1993). "Metabolic Precursors to Amphetamine and Methamphetamine". Forensic Science Review. 5 (2): 109- ... a therapeutic strategy for Parkinson's disease?". BioEssays. 26 (1): 80-90. doi:10.1002/bies.10378. PMID 14696044.. ... "Neuroprotection of MAO-B inhibitor and dopamine agonist in Parkinson disease". International Journal of Clinical and ...
Diseases of the endocrine system (ICD-10 Chapter IV: Endocrine, nutritional and metabolic diseases - Endocrine diseases, E00- ... Diabetes was one of the first diseases described.[21] The importance of insulin in the disease was determined in the 1920s.[22] ... two to four times the risk of cardiovascular disease, including ischemic heart disease and stroke; a 20-fold increase in lower ... "Exercise and disease management (2nd ed.). Boca Raton: CRC Press. p. 25. ISBN 978-1-4398-2759-8. . OCLC 725919496.. ...
cellular protein metabolic process. · ventricular cardiac muscle cell development. · cellular response to hypoxia. ... Dense Deposit Disease/Membranoproliferative Glomerulonephritis Type II. 19 May 2011. PMID 20301598. NBK1425.. In GeneReviews ... Life at the edge: the nuclear envelope and human disease. Nat. Rev. Mol. Cell Biol. 2002, 3 (8): 575-85. PMID 12154369. doi: ... Mutations in the LMNA gene are associated with several diseases, including Emery-Dreifuss muscular dystrophy, familial partial ...
Metabolic alterations including hyperlipidemia (cholesterol or triglyceride elevations) and hyperglycemia. *Alterations in body ... Impairs endothelial function in healthy HIV-negative men and may accelerate atherosclerotic disease.[10] ... It significantly increased life expectancies and decreased noticeable symptoms from infectious diseases that were the result of ... Capaldini L (August 1997). "Protease inhibitors' metabolic side effects: cholesterol, triglycerides, blood sugar, and "Crix ...
Heritable disease and multifactorial inheritance[edit]. A mutation resulting in a disease state is often recessive, so both ... found beneficial to identify the gene responsible by a cross-validation of genes within the interacting loci with metabolic ... If it is shown that the brothers and sisters of the patient have the disease, then there is a strong chance that the disease is ... Alzheimer's Disease. Multifactorially inherited diseases are said to constitute the majority of genetic disorders affecting ...
... functional imaging technique that is used to observe metabolic processes in the body as an aid to the diagnosis of disease. The ... Infectious diseasesEdit. Imaging infections with molecular imaging technologies can improve diagnosis and treatment follow-up. ... Cardiology, atherosclerosis and vascular disease study: In clinical cardiology, FDG-PET can identify so-called "hibernating ... March 1999). "In vivo mapping of cerebral acetylcholinesterase activity in aging and Alzheimer's disease". Neurology. 52 (4): ...
Fowk wi endocrine, nutreetional an metabolic diseases. *Preses o the Philippines. *Filipino Roman Catholics ...
This article is about a skin disease common during adolescence. For other acneiform skin diseases, see Acne (disambiguation). ... Kuhl H (1997). "Metabolische Effekte der Östrogene und Gestagene" [Metabolic effects of estrogens and progestogens]. Der ... Disease Primers. 1: 15033. doi:10.1038/nrdp.2015.33. PMID 27227877.. *^ a b "Frequently Asked Questions: Acne" (PDF). U.S. ... Acne, also known as acne vulgaris, is a long-term skin disease that occurs when dead skin cells and oil from the skin clog hair ...
These vibrations result in an increase in the metabolic demands of the auditory system. During exposure to sound, metabolic ... any major damage or loss of these hair cells leads to permanent hearing impairment and other hearing-related diseases.[2] Outer ... The extra demands on the metabolic activity of the system can result in damage that can propagate throughout the ear. ... Physical activity also results in an increase in metabolic activity, which has already been increased as a result of the ...
lipid metabolic process. • very-low-density lipoprotein particle assembly. • very-low-density lipoprotein particle clearance. ... 2008). "Newly identified loci that influence lipid concentrations and risk of coronary artery disease". Nat. Genet. 40 (2): 161 ... "Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk". Hum. Mol. Genet ... "APOE/C1/C4/C2 gene cluster genotypes, haplotypes and lipid levels in prospective Coronary Heart Disease Risk among UK healthy ...
Human diseaseEdit. Kluyveromyces marxianus is not usually an agent of human disease, although infection in humans can occur in ... "Physiological and metabolic diversity in the yeast Kluyveromyces marxianus". Antonie van Leeuwenhoek. 100 (4): 507-519. doi: ... an Emerging Pathogen in Patients with Oncohematological Diseases?". Clinical Infectious Diseases. 43 (5): 666-667. doi:10.1086/ ...
Mandel SJ, Brent GA, Larsen PR (September 1993). "Levothyroxine therapy in patients with thyroid disease". Annals of Internal ... as thyroid hormones may cause an acute adrenal crisis by increasing the metabolic clearance of glucocorticoids.[20] For oral ... For older people (over 50 years old) and people with known or suspected ischemic heart disease, levothyroxine therapy should ... T4 and T3 bind to thyroid receptor proteins in the cell nucleus and cause metabolic effects through the control of DNA ...
FPL also refers to a rare metabolic condition in which there is a loss of subcutaneous fat in the arms, legs and lower torso. ... 2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0. Herbst KL, Tannock LR, Deeb ... There is an increased risk of coronary heart disease. Cardiomyopathy and muscular dystrophy may occur rarely. Xanthoma and nail ... Familial partial lipodystrophy (FPL), also known as Köbberling-Dunnigan syndrome, is a rare genetic metabolic condition ...
listen)) is the science and practice of the diagnosis, treatment, and prevention of disease.[4][5] The word "medicine" is ... metabolic pathway, blood flow, or other), and a radionuclide (usually either a gamma-emitter or a positron emitter). There is a ... Preventive medicine is the branch of medicine concerned with preventing disease. *Community health or public health is an ... Pathology as a medical specialty is the branch of medicine that deals with the study of diseases and the morphologic, ...
sulfur compound metabolic process. • metanephric S-shaped body morphogenesis. • metanephros development. • cellular response to ... differentiation and disease". Nature Reviews. Endocrinology. 11 (1): 29-42. doi:10.1038/nrendo.2014.186. PMID 25350068.. ... "Thyroid hormone resistance and increased metabolic rate in the RXR-gamma-deficient mouse". The Journal of Clinical ... "Pax genes in renal development, disease and regeneration". Seminars in Cell & Developmental Biology. Paramutation & Pax ...
Chronic illnesses, malnutrition, endocrine, metabolic disorders or chromosomal anomalies are characterized by proportionate ... chronic kidney disease, being small for gestational age at birth, Prader-Willi syndrome, Wiedemann-Steiner syndrome, or other ... disease of a major organ system, mistreatment, treatment with certain drugs, chromosomal deletions. Human growth hormone (HGH) ... have worked to medicalize short stature by convincing the public that short stature is a disease rather than a natural ...
Intended for use in the diagnosis of disease or other conditions, or in the cure, mitigation, treatment, or prevention of ... and which does not achieve its principal intended action in or on the human body by pharmacological, immunological or metabolic ... diagnosis, prevention, monitoring, treatment or alleviation of disease,. *diagnosis, monitoring, treatment, alleviation of or ... cure or prevention of diseases in humans or other animals; intended to affect the structure or functions of the body of man or ...
"Metabolic syndrome pathophysiology: The role of adiposetissue". Nutrition, Metabolism and Cardiovascular Diseases. 17 (2): 125 ... Mixed connective tissue disease - a disease of the autoimmune system, also undifferentiated connective tissue disease. ... Congenital diseases include Marfan syndrome and Ehlers-Danlos Syndrome.. *Myxomatous degeneration - a pathological weakening of ... Systemic lupus erythematosus (SLE) - a major autoimmune disease of connective tissue. *Scurvy, caused by a deficiency of ...
Hourigan CS (2006). "The molecular basis of coeliac disease". Clin Exp Med (Review). 6 (2): 53-59. doi:10.1007/s10238-006-0095- ... Glia come in several types, which perform a number of critical functions, including structural support, metabolic support, ... GBD 2015 Disease and Injury Incidence and Prevalence, Collaborators. (8 October 2016). "Global, regional, and national ... Hodgson TS, Nielsen SM, Lesniak MS, Lukas RV (2016). "Neurological Management of Von Hippel-Lindau Disease". Neurologist ( ...
"Microbial Ecology in Health and Disease. 30 (sup1): 1535737. doi:10.1080/16512235.2018.1535737. PMC 6225515. PMID 30425610.. ... Bacteria in the large intestine further break down the material.[1][2] Feces contain a relatively small amount of metabolic ... For other types of body waste, see metabolic waste. For the American punk rock band, see Fecal Matter (band). ... Stokstad, Erik (28 July 2000). "Divining Diet and Disease From DNA". Science. 289 (5479): 530-531. doi:10.1126/science.289.5479 ...
Symptoms of disease are more severe in males, who are generally diagnosed in early childhood. Children afflicted by CLS display ... Metabolic. *Amino acid: Ornithine transcarbamylase deficiency. *Oculocerebrorenal syndrome. *Dyslipidemia: Adrenoleukodystrophy ... The prevalence of CLS is uncertain due to the rarity of the disease, but CLS is estimated to affect between 1 in 50,000 and 1 ... In 20-30% of cases, however, there is a family history of disease. In these cases, the disorder is typically inherited from the ...
... and metabolic diseases (diabetes, cystinosis). Structural abnormalities of the kidneys are identified with imaging tests. These ... and systemic diseases that occur as a result of kidney disease, such as renal osteodystrophy and hypertension. A physician who ... the study of normal kidney function and kidney disease, the preservation of kidney health, and the treatment of kidney disease ... Many diseases affecting the kidney are systemic disorders not limited to the organ itself, and may require special treatment. ...
Although death by suicide in schizophrenia has received much needed attention, death from cardiovascular disease is far more ... The fatal conditions include cardiovascular, respiratory and metabolic disorders. ... Schizophrenia and increased risks of cardiovascular disease. Am Heart J 2005; 150(6): 1,115-21. Phelan, M; et al. (2001). " ...
A common example of pleiotropy is the human disease phenylketonuria (PKU). This disease causes mental retardation and reduced ... Metabolic supermice. *Polygene. References[edit]. *^ a b Paaby, Annalise B.; Rockman, Matthew V. (2016-11-15). "The many faces ... "Complications and Treatments , Sickle Cell Disease". CDC. Retrieved 2016-11-11.. *^ a b c d "Marfan Syndrome". National ... "sickle cell disease". Genetics Home Reference. Retrieved 2016-11-11.. *^ MD, Kenneth R. Bridges. "How Does Sickle Cell Cause ...
Paterson, Sue (December 17, 2007). Skin Diseases of Exotic Pets. Blackwell Science, Ltd. pp. 74-79. ISBN 9780470752432. .. ... The allantois (8) is a sac that collects the metabolic waste produced by the embryo. The amniotic sac (10) contains amniotic ... Hellebuyck, Tom; Pasmans, Frank; Haesbrouck, Freddy; Martel, An (July 2012). "Dermatological Diseases in Lizards". The ... a common skin disease in snakes and lizards, will occur when ecdysis, or shedding, fails.[94] There are numerous reasons why ...
Several efficient benzodiazepines offer choices about dosage form, length of action, metabolic interaction and safety. ... "Neuropsychiatric Disease and Treatment. 1 (4): 329-43. PMC 2424120. PMID 18568113.. .mw-parser-output cite.citation{font-style: ...
"Effect of a 21 day Daniel Fast on metabolic and cardiovascular disease risk factors in men and women" (PDF). Lipids in Health ... 2006). "Low-carbohydrate-diet score and the risk of coronary heart disease in women". N. Engl. J. Med. 355 (19): 1991-2002. doi ... Jennifer Petrelli; Kathleen Y. Wolin (2009). Obesity (Biographies of Disease). Westport, Conn: Greenwood. p. 11. ISBN 978-0-313 ... 2006). "Low-fat dietary pattern and risk of cardiovascular disease: the Women's Health Initiative Randomized Controlled Dietary ...
"OIE Listed Diseases and Other Diseases of Importance" (PDF). Terrestrial Manual. 2012. Archived from the original (PDF) on ... It is commonly characterised by rupture or absorption of the spore coat, swelling of the endospore, an increase in metabolic ... Examples of bacteria having terminal endospores include Clostridium tetani, the pathogen that causes the disease tetanus. ... Germination involves the dormant endospore starting metabolic activity and thus breaking hibernation. ...
Heinonen EH, Myllylä V (July 1998). "Safety of selegiline (deprenyl) in the treatment of Parkinson's disease". Drug Saf. 19 (1 ... "Moclobemide treatment causes a substantial rise in the sparteine metabolic ratio. Danish University Antidepressant Group". Br ... Reversible MAOIs such as moclobemide may have advantages in the treatment of depression associated with Alzheimer's disease due ... Tikal K, Hrabánková M (June 1993). "[Indications for antidepressive agents in relation to diseases of the cardiovascular system ...
... metabolic syndrome, and type 2 diabetes mellitus. One important pathway that may link these metabolic diseases to sugar ... Richelsen B. Sugar-sweetened beverages and cardio-metabolic disease risks. Curr Opin Clin Nutr Metab Care. 2013;16(4):478-484. ... Conversion of Sugar to Fat: Is Hepatic de Novo Lipogenesis Leading to Metabolic Syndrome and Associated Chronic Diseases?. The ... Bugianesi E, McCullough AJ, Marchesini G. Insulin resistance: a metabolic pathway to chronic liver disease. Hepatology. 2005;42 ...
... including metabolic diseases, such as obesity and diabetes, and cardiovascular diseases. This is because alterations in the ... Microbiota Microbiome Diabetes Obesity Cardiovascular disease Metabolic syndrome Abbreviations. AMPK. AMP-Activated protein ... P.D. Cani, N.M. Delzenne, The role of the gut microbiota in energy metabolism and metabolic disease. Curr. Pharm. Des. 15, 1546 ... 2.Diabetes and endocrine and metabolic diseases Unit and the Centre for Applied Clinical Research (Ce.R.C.A.) Clinical ...
... diseases of the cardiac valves, and metabolic disorders, many of which can only be identified or ruled out histopathologically ... Potentially fatal diseases include vascular diseases, diseases of the cardiac valves, and metabolic disorders, many of which ... Dettmeyer R.B. (2018) Vascular, Cardiac Valve, and Metabolic Diseases. In: Forensic Histopathology. Springer, Cham. * DOI https ... Rozin L, Koehler SA, Shakir A, Ladham S, Wecht CH (2003) Kawasaki disease: a review of pathologic features of stage IV disease ...
Instructions for Authors Types of papers Metabolic Brain Disease is committed to high standards of presentation and will ... Metabolic Brain Disease is committed to high standards of presentation and will consider:. Research Papers: No page limitations ...
Understanding metabolic syndrome, a cluster of conditions including high blood pressure and obesity, can help prevent symptoms ... Metabolic Syndrome Can Increase Your Risk of Other Chronic Diseases. Find out what you can do to prevent strokes and heart ... Kidney disease. People with metabolic syndrome have a 55 percent increased risk of developing kidney problems, according to a ... "About half of all patients that we diagnose with metabolic syndrome already have undiagnosed cardiovascular disease, such as ...
... Metabolic Brain Disease serves as a forum for the publication of outstanding basic and ... diseases affecting neurotransmitters, Alzheimers disease, Parkinsons disease, amyotrophic lateral sclerosis and aging. The ... Metabolic Brain Disease is directed to neuroscientists, psychiatrists, neurologists, pathologists, and others involved in the ... genetic diseases affecting the brain, alcohol and brain metabolism, neuroendocrinopathies, viral and nonviral encephalitides, ...
Stress affects circadian rhythm, increases metabolic disease risk Stress is a normal part of life, but too much of everything ... Study shows why fatty liver disease contributes to increase in liver cancer Fatty liver disease is contributing to an increase ... NIH grants boost rare diseases research efforts Of an estimated 6,500 to 7,000 known rare diseases, only a fraction - maybe 5 ... it can increase the risk of developing metabolic diseases. ... Chronic disease prevention could help curb the opioid epidemic ...
... is for the researchers, scientists, scholars, engineers, academic, scientific and ... Metabolic Diseases. Metabolic Diseases Conferences in 2022. Metabolic Diseases Conferences in 2022 is an indexed listing of ... ICMD 2022: Metabolic Diseases Conference, Tokyo (Mar 25-26, 2022) * ICGMS 2022: Genetics of the Metabolic Syndrome Conference, ... ICMS 2022: Metabolic Syndromes Conference, Athens (Apr 08-09, 2022) * ICVMD 2022: Vascular and Metabolic Diseases Conference, ...
Working with community partners to better inform and empower the population about obesity and metabolic diseases. ... Advancing our understanding of obesity and metabolic diseases and their effects in human populations. ... metabolic syndrome, diabetes, and associated metabolic disorders in Central Appalachia. The mission statement is accomplished ... outreach strategies to prevent obesity and metabolic diseases. * ... for prevention of obesity and metabolic diseases. *To obtain ...
Metabolic bone disease: The normal function of bone requires an adequate supply of amino acids (the building blocks for ... Skeletal disease, when it is due to inadequacies in the supply or action of the above essentials, associated with abnormalities ... outside the skeleton, is termed metabolic; in such cases the entire skeleton is affected. ... Metabolic bone disease. The normal function of bone requires an adequate supply of amino acids (the building blocks for ...
Cancer is a metabolic disease, not a genetic one. As long as your mitochondria remain healthy and functional, your chances of ... Cancer is a metabolic disease, not a genetic one. As long as your mitochondria remain healthy and functional, your chances of ... Cancer as a Metabolic Disease The traditionally held view or dogma is that cancer is a genetic disease, but what Warburg ... On the other hand, when you view cancer as a metabolic disease, you can target and manage the disease without creating systemic ...
Cancer is a metabolic disease, not a genetic one. As long as your mitochondria remain healthy and functional, your chances of ... Cancer as a Metabolic Disease The traditionally held view or dogma is that cancer is a genetic disease, but what Warburg ... On the other hand, when you view cancer as a metabolic disease, you can target and manage the disease without creating systemic ... Cancer as a Metabolic Disease - A New Look at an Old Foe Previous Article Next Article ...
The Metabolic Clinic consists of a multidisciplinary team dedicated to providing care to children with known or suspected ... The Metabolic Clinic staff evaluates patients with a history concerning for a metabolic disease. The evaluation process ... This team includes metabolic physicians, genetic counselors, a metabolic dietitian and a metabolic social worker. ... The Texas State Department of Health (TDSH) screens approximately 400,000 newborns annually for inherited metabolic diseases ...
Purchase Metabolic and Degenerative Diseases of the Central Nervous System - 1st Edition. Print Book & E-Book. ISBN ... metabolic or degenerative. Metabolic and Degenerative Diseases of the Central Nervous System is intended to provide a sound ... Metabolic and Degenerative Diseases of the Central Nervous System 1st Edition. Pathology, Biochemistry, and Genetics. ... Metabolic and Degenerative Diseases of the Central Nervous System is a comprehensive reference work that provides the ...
40 Studies found for: Diseases, Metabolic , Adrenomyeloneuropathy. Also searched for Adrenoleukodystrophy, Metabolic Disease ... in Patients With Inherited Metabolic Diseases. *Inherited Metabolic Diseases ... UCB Transplant of Inherited Metabolic Diseases With Administration of Intrathecal UCB Derived Oligodendrocyte-Like Cells. * ... Number of Patients With Grade 0 Graft-Versus-Host Disease (GVHD). *Number of Patients With Grade 1 Graft-Versus-Host Disease ( ...
... Manoj Kumar,1 Ravinder Nagpal,2 Rajesh ... WHO, "Diet, Nutrition and Prevention of Chronic Diseases," Report of a Joint WHO/FAO Expert Consultation, Geneva, Switzerland, ... Cardiovascular diseases are one of the major causes of deaths in adults in the western world. Elevated levels of certain blood ... R. Nagpal, P. V. Behare, M. Kumar et al., "Milk, milk products and disease free health: an updated overview," Critical Reviews ...
NF-κB, inflammation, and metabolic disease.. Baker RG1, Hayden MS, Ghosh S. ... and development of metabolic diseases. Consistent with its central role in coordinating inflammatory responses, numerous recent ... Metabolic disorders including obesity, type 2 diabetes, and atherosclerosis have been viewed historically as lipid storage ... Nutrient excess is sensed in peripheral metabolic tissues to result in production of pro- inflammatory cytokines IL-6, IL-1 and ...
Advancements in our understanding of the interactions between NAFLD and metabolic syndrome-associated disorders could help ... Shared Disease Mechanisms Between Nonalcoholic Fatty Liver Disease and Metabolic Syndrome. Translating Knowledge From Systems ... Aim To use systems biology strategies to interrogate disease mechanisms that are common to NAFLD and metabolic syndrome. ... Non-alcoholic fatty liver disease (NAFLD) is the most prevalent cause of chronic liver disease worldwide.[1,2,3] Non-alcoholic ...
Novel metabolic biomarkers of cardiovascular disease.. Jensen MK1, Bertoia ML1, Cahill LE1, Agarwal I1, Rimm EB2, Mukamal KJ3. ... Coronary heart disease (CHD) accounts for one in every six deaths in US individuals. Great advances have been made in ... In this Review, we summarize ongoing scientific research in a number of metabolic molecules or features, including lipoproteins ...
Diets high in fructose can rapidly produce all of the key features of the metabolic syndrome. Here we review the biology of ... As a result of its unique metabolic properties, the fructose component of sugar may be particularly harmful. ... metabolism as well as potential mechanisms by which excessive fructose consumption may contribute to cardiometabolic disease. ...
Barth syndrome is a rare metabolic disease in boys caused by mutation of a gene called tafazzin or TAZ. It can cause life- ... Stress affects circadian rhythm, increases metabolic disease risk Stress is a normal part of life, but too much of everything ... Recently discovered protein may play key role in obesity and metabolic disease With unexpected findings about a protein thats ... High testosterone in women ups risk for cancer, diabetes, and metabolic disease Testosterone is a steroid hormone that triggers ...
Minireview: Estrogenic protection of beta-cell failure in metabolic diseases. Endocrinology 2010;151:859-864pmid:19966178. ... Estrogen Sulfotransferase: Intracrinology Meets Metabolic Diseases Message Subject (Your Name) has forwarded a page to you from ... adds a novel dimension of estrogen intracrinology to our knowledge of metabolic diseases. It is now emerging that estrogen ... Ambient Air Pollution and Type 2 Diabetes: Do the Metabolic Effects of Air Pollution Start Early in Life? ...
A newly discovered biomarker associated with a rare metabolic disorder may facilitate better diagnosis and identification of ... new drugs for clinical trials for the disease. Development of treatments for the neurological symptoms of mucopolysaccharidoses ... New biomarker found for group of rare metabolic diseases Development may facilitate quicker, more accurate diagnosis to aid in ... New biomarker found for group of rare metabolic diseases. University of Pennsylvania School of Medicine ...
Results: The therapeutic aims of surgery for obesity and/or metabolic disease are to improve the quality of life and to prolong ... Obesity Surgery and the Treatment of Metabolic Diseases. Dtsch Arztebl Int 2018; 115(42): 705-11; DOI: 10.3238/arztebl. ... Surgery for obesity and metabolic disease is less common in Germany than in the neighboring Western European countries (Germany ... In the presence of an appropriate indication, the various surgical treatment options for obesity and/or metabolic disease ...
... in consultation with metabolic disease specialists. A multitier system could be designed, depending on methodology, metabolic ... Another challenge to the definitive diagnosis of metabolic disease is that persons with one of these disorders might by ... All MS/MS used for metabolic disease detection requires high-purity compressed nitrogen delivered at a specified pressure. This ... Treatment resources might be inadequate as a result of the rarity of metabolic diseases among newborns; therefore, ensuring ...
... Nat Rev Endocrinol. 2009 Jul;5(7):401-8. doi: 10.1038 ... outcome of adaptive plasticity and the current environment increases the risk of metabolic and cardiovascular disease. These ... to stable changes in the epigenome that alter the individuals susceptibility to chronic metabolic and cardiovascular disease, ... 1 Centre for Human Evolution, Adaptation and Disease, Liggins Institute, The University of Auckland, New Zealand. [email protected] ...
Metabolic diseases, congenital metabolic defects, disorders of the brain (epilepsy) and growth failure ... Metabolic diseases. .. Organ-specific and general paediatric care is offered to patients in all three work groups, including ... Our Department is a major centre for the treatment of kidney, liver and metabolic diseases. It has become a leader in the care ... Paediatric Kidney, Liver and Metabolic Diseases. Professor Dr. med. Dieter Haffner, Director of the Department of Paediatric ...
this article has been prepared to help you understand how hair disorders can affect you, what tests are used, and what treatment is available. it outlines the advantages and disadvantages of different treatments.. ...
This site is used to accumulate student created resources relating to relationships between a number of chronic disease states ... Retrieved from "" ... Students will evaluate the pathophysiology and functional consequences of metabolic conditions including obesity, ... implementation and evaluation of intervention skills required for the practice of exercise physiology in cancers and metabolic ...
... 15.02.2007. Dutch researcher Terry Derks has demonstrated that the metabolic disease MCAD ... A recently developed screening method makes it possible to screen newborns for several metabolic diseases, such as MCAD ... which can cause the disease. From this the expected number of patients was 1:12,100. And how often was this disease found? ... Therefore the disease was not discovered in more than half of the patients. With the heel prick screening in the northern part ...
  • This is because alterations in the microbiota composition can cause insulin resistance, inflammation, vascular, and metabolic disorders. (
  • Potentially fatal diseases include vascular diseases, diseases of the cardiac valves, and metabolic disorders, many of which can only be identified or ruled out histopathologically. (
  • Metabolic Brain Disease is directed to neuroscientists, psychiatrists, neurologists, pathologists, and others involved in the research and treatment of a broad range of brain disorders. (
  • Improving the quality of life in the Central Appalachian region and beyond by creating an environment free from the health consequences of obesity, diabetes, and associated metabolic disorders. (
  • To provide scientific expertise and partnership opportunities for the prevention, detection, and management of obesity, metabolic syndrome, diabetes, and associated metabolic disorders in Central Appalachia. (
  • Working with clinicians and health care professionals to better detect and manage patients with obesity, metabolic syndrome, diabetes, and associated metabolic disorders. (
  • The Outi Mäkitie research group studies genetic defects and clinical factors underlying skeletal disorders, with main interests in early-onset primary and secondary osteoporosis, skeletal dysplasias, and vitamin D. Our aim is to enhance understanding of disease mechanisms and establish means for early diagnosis, prevention and treatment in childhood-onset skeletal disorders. (
  • This includes Gaucher disease, Fabry disease, and mucopolysaccharidoses (MPS disorders) such as Hurler, Sanfilippo and Morquio syndromes. (
  • The relationship among sleep quality, duration, regularity and metabolic disorders is an unknown territory. (
  • We know that OSAS/disturbed sleep has a causative role in most metabolic and cardiovascular disorders and possibly even in cancer. (
  • entitled "The Relationship between Simple Snoring and Metabolic Syndrome: A Cross-Sectional Study" assessed the cross-sectional relationship between simple snoring and metabolic syndrome in a sample of 866 adults from southeastern China without diagnosed sleep breathing disorders, such as apnea and hypoxia. (
  • The overall findings not only suggest that simple snoring is independently linked to metabolic syndrome but also that snoring severity linearly relates to metabolic score and that females are more vulnerable to metabolic disorders. (
  • Metabolic disorders including obesity, type 2 diabetes, and atherosclerosis have been viewed historically as lipid storage disorders brought about by overnutrition. (
  • Characterised by abnormal fat accumulation in the liver, NAFLD presents high degree of comorbidity with disorders of the metabolic syndrome, including type 2 diabetes, obesity and cardiovascular disease. (
  • Likewise, gene-based disease-enrichment analysis suggested underlying molecular effectors that are shared with major systemic disorders, including diverse autoimmune diseases, kidney, respiratory and nervous system disorders, cancer and infectious diseases. (
  • In addition, NAFLD presents high degree of concomitance with the Metabolic syndrome-associated disorders, including type 2 diabetes, obesity, cardiovascular disease and dyslipidemia. (
  • Therefore, our aim was to map gene/protein-disease interaction networks, which would conceptually allow the identification of molecular mediators that link related disorders/diseases. (
  • Increasingly, tandem mass spectrometry (MS/MS) is being used for newborn screening because this laboratory testing technology substantially increases the number of metabolic disorders that can be detected from dried blood-spot specimens. (
  • Detectable disorders include metabolic disorders (e.g., phenylketonuria [PKU]), hematologic disorders (e.g., sickle cell disease), and endocrinopathies (e.g., congenital hypothyroidism). (
  • These three groups of disorders account for approximately 3,000 new cases of potentially fatal or debilitating disease each year for which outcomes are improved with early identification and treatment through newborn screening systems. (
  • The introduction of tandem mass spectrometry (MS/MS) in the 1990s for population-based newborn screening has enabled health-care providers to detect an increased number of metabolic disorders in a single process by using dried blood-spot specimens routinely collected from newborns ( 13 ). (
  • MS/MS technology enables improvements in and consolidation of metabolic screening methods to detect amino acid disorders (e.g. (
  • MS/MS technology expands the metabolic disorder screening panel (i.e., the number of disorders that can be detected) by incorporating an acylcarnitine profile, which enables detection of fatty acid oxidation disorders (e.g., medium-chain acyl-CoA dehydrogenase [MCAD] deficiency) ( 7-10 ) and other organic acid disorders. (
  • Internationally, Professor Haffner is involved in the cooperation and coordination of clinical research on topics such as growth and development, cardiovascular health and bone disease in children with renal disorders. (
  • Our own metabolic laboratory is able to analyse complex disorders of amino and organic acids and respiratory chain defects. (
  • Research groups on congenital and acquired kidney and liver diseases, neurological and metabolic disorders focus on the cause of these diseases, while also continuing to develop innovative diagnostic and treatment strategies. (
  • Inherited metabolic diseases are a group of disorders that result in missing or defective enzymes. (
  • Rice GM, Steiner RD. Inborn Errors of Metabolism (Metabolic Disorders). (
  • Now University of Utah Health scientists say they have detected new genetic clues about this phenomenon that could lead to better understanding and treatment of obesity and metabolic disorders that afflict millions worldwide. (
  • Analysis of the different disorders that make up metabolic syndrome showed a similar pattern of increasing prevalence with psoriasis severity. (
  • Like people, dogs develop a variety of metabolic disorders as they age. (
  • Further complicating this is that many owners dismiss the symptoms of metabolic disorders as natural outcomes of advanced age. (
  • However, by watching for signs, consulting your vet, and learning about metabolic disorders in older dogs, you'll be able to diagnose and get treatment for your dog quickly. (
  • Unfortunately, many owners confuse the symptoms of metabolic disorders with the natural signs of age. (
  • Know which breeds are more prone to metabolic disorders. (
  • Certain dog breeds are more prone to metabolic disorders than others. (
  • Generally, mixed breed dogs have a lower risk of developing metabolic disorders. (
  • German shepherds, boxers, spaniels, and certain types of terriers are prone to a variety of metabolic disorders. (
  • You need to make sure to differentiate the symptoms of old age from symptoms of metabolic disorders. (
  • Veterinary specialists often have more training and experience dealing with diseases and disorders that are somewhat uncommon. (
  • Depending on the school, it will likely have a specialist who focuses on canine metabolic disorders. (
  • It increases our risk of developing metabolic disorders, such as obesity and diabetes, and can shorten our life expectancy by several years. (
  • The condition is one of the congenital disorders of glycosylation or CDG, a group of syndromes in which inborn metabolic errors result in serious, sometimes fatal, malfunctions of different organ systems, especially the nervous system, muscles and intestines. (
  • The Charles Dent Metabolic Unit (CDMU) is one of the largest and longest established services in the world for the treatment of adolescents and adults (aged 16 years and older) with inherited metabolic diseases, including, among others, phenylketonuria, homocystinuria, galactosemia, fatty acid oxidation defects, glycogen storage disorders, X-linked hypophosphatemia, peroxisomal and urea cycle defects. (
  • To obtain urgent advice by telephone - GPs, A&E staff or other medical staff can contact switchboard (0845 155 5000 or 020 3456 7890) at University College London Hospital, and ask for the consultant-on-call for adult inherited metabolic disorders and lysosomal storage disorders at Queen Square. (
  • Individuals with inherited metabolic disorders usually require lifetime follow-up. (
  • The Committee on Fetus and Newborn considered four types of screening programs: (1) screening of all newborn infants, (2) screening of specific groups of neonates with increased risk of certain disorders, (3) large scale, pilot-screening programs, designed primarily for research and acquisition of knowledge about the natural history of disease, (4) screening of expectant mothers, particularly using tests of amniotic fluid. (
  • Researchers in the U.K. are looking to breed marijuana to make medicines for metabolic disorders, epilepsy, and other diseases. (
  • Treatment for metabolic disorders varies with the symptoms. (
  • Inherited metabolic disorders may be treated using nutritional guidance, physical therapy, regular assessments and support. (
  • The authoritative reference to bone diseases and disorders of mineral metabolism, revised and update. (
  • Now in its ninth edition, The Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism offers an updated and comprehensive guide to bone and mineral health. (
  • The ninth edition provides concise coverage of the widest possible spectrum of metabolic bone diseases and disorders of mineral metabolism. (
  • The new edition of this invaluable reference expands coverage and includes the most recent developments in the field that help to strengthen its usefulness and ensure that the Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism maintains its place as the pre-eminent reference on bone and mineral health. (
  • Written for advanced students, clinicians, and researchers working in the field of bone health and disease, Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism is the definitive, one-stop reference for anyone working in the field of bone health and disease. (
  • Collectively, their projects lead to a better understanding of these diseases' risk factors, including genetic factors, hypertension, dyslipidemia, endothelial cell dysfunctions and metabolic disorders. (
  • Parasite-infected dragonflies suffer the same metabolic disorders that have led to an epidemic of obesity and type-2 diabetes in humans, reveal the findings of research conducted at Penn State University that are due to be published in the 5 December 2006 issue of the Proceedings of the National Academy of Science and also in the PNAS early online edition at on 21 November. (
  • The work raises a fascinating question about what role microbial communities found in human intestines may play in human metabolic disorders like insulin resistance, type-2 diabetes, and obesity. (
  • In mammals, these metabolic disorders are known to be associated with a chronic inflammatory response, thought to be triggered by an accumulation of fat. (
  • Vitamin D Signaling through Induction of Paneth Cell Defensins Maintains Gut Microbiota and Improves Metabolic Disorders and Hepatic Steatosis in Animal Models. (
  • The division provides research funding and support for basic and clinical research and research training in diabetes, and other metabolic and endocrine disorders. (
  • Ronald Evans, Director of Salk's Gene Expression Laboratory, claimed the work could pave the way for new clinical interventions for those suffering with obesity and other metabolic disorders . (
  • Several metabolic disorders, such as diabetes, hypertension, dyslipidemia, and obesity, represent significant risk factors for cardiovascular disease, which is the leading cause of morbidity and mortality among adult populations in western societies. (
  • Understandably, these chronic disorders have now replaced infectious diseases as the most important public health problem and economic burden to society in most countries. (
  • This review discusses the development of innovative therapeutic agents, focusing on the use of molecular vaccines for the treatment of common and highly prevalent chronic metabolic disorders, ie, diabetes, hypertension, dyslipidemia, and obesity. (
  • We aim to identify the mechanisms by which mitochondrial dysfunction participates in the development of complex metabolic disorders such as obesity, insulin resistance, and type 2 diabetes. (
  • Some external environmental factors (i.e., air pollution) coupled with a wrong diet might increase the risk of cardiovascular diseases and metabolic disorders. (
  • For orthopaedists, emphasis is placed on operative and non-operative management of all problems of musculoskeletal disorders, including diseases of the lumbar spine, trauma, orthopaedic oncology, and degenerative diseases. (
  • The aim of this review is to focus on the potential benefits of a dietary supplement of myo-inositol, by far the most common inositol isomer in foodstuffs, in human disorders associated with insulin resistance (polycystic ovary syndrome, gestational diabetes mellitus or metabolic syndrome) or in prevention or treatment of some diabetic complications (neuropathy, nephropathy, cataract). (
  • The Metabolic Bone Disease & Endocrine Calcium Center is comprised of a team of expert physician-scientists who specialize in the treatment of a vast number of common and rare bone, calcium and other mineral disorders associated with the regulation of skeletal and parathyroid hormone functions. (
  • Metabolic bone disease is an abnormality of bones caused by a broad spectrum of disorders. (
  • Conversion of Sugar to Fat: Is Hepatic de Novo Lipogenesis Leading to Metabolic Syndrome and Associated Chronic Diseases? (
  • Epidemiologic studies suggest a link between excess sugar consumption and obesity, fatty liver disease, metabolic syndrome, and type 2 diabetes mellitus. (
  • You're one of the millions of Americans at risk of developing metabolic syndrome, a cluster of health conditions that includes obesity, high blood pressure, type 2 diabetes and abnormal cholesterol. (
  • About half of all patients that we diagnose with metabolic syndrome already have undiagnosed cardiovascular disease, such as changes in the walls of their blood vessels that haven't yet caused symptoms," Bruemmer says. (
  • People with metabolic syndrome are more likely to develop a condition known as insulin resistance, in which your body's cells don't respond normally to the hormone insulin. (
  • A 2017 study published in the J ournal of Epidemiology found that people with just two risk factors for metabolic syndrome were over four times as likely to develop type 2 diabetes over a five-year period, while people with four risk factors were about 10 times more likely. (
  • As a result, people with metabolic syndrome are three times more likely to have a stroke or heart attack than those who don't have it, according to the American College of Cardiology. (
  • There's no magic pill to reverse metabolic syndrome, but you can help reduce your risk of developing potentially deadly complications by getting various risk factors under control, Bruemmer says. (
  • To carry out scientific studies for characterizing obesity, metabolic syndrome, and diabetes in human populations. (
  • Sleep-Disordered Breathing Is Associated with Metabolic Syndrome in Outpatients with Diabetes Mellitus Type 2," uses the severity of OSAS to assess the relationship with the metabolic syndrome in subjects with type 2 diabetes mellitus. (
  • These comorbidities have strong negative impact on the natural course of NAFLD and vice versa, whereby the presence of NAFLD substantially modifies the course and prognosis of metabolic syndrome-associated diseases. (
  • Aim To use systems biology strategies to interrogate disease mechanisms that are common to NAFLD and metabolic syndrome. (
  • Considered jointly, the aforementioned evidence suggests the existence of shared pathogenic mechanisms between NAFLD and Metabolic syndrome-associated diseases. (
  • It thus becomes essential not only to uncover the shared pathogenic networks that link NAFLD, NASH, and Metabolic syndrome but also to understand how they interact with each other to define combined preventive strategies and to explore novel therapeutic approaches. (
  • Here, we hypothesise that NAFLD and the Metabolic syndrome phenotypes present common etiology and share similar underlying biological processes. (
  • Diets high in fructose can rapidly produce all of the key features of the metabolic syndrome. (
  • Barth syndrome is a rare metabolic disease in boys caused by mutation of a gene called tafazzin or TAZ. (
  • The new mitochondrial DNA (mtDNA) variant drastically speeds up the disease progression in a mouse model of GRACILE syndrome. (
  • As an experimental confirmation, it was observed that elimination of the aromatase or ERα genes in male and female mice produced the same metabolic syndrome as in humans ( 3 , 4 ). (
  • In patients with obesity and metabolic syndrome, EST correlates with the expression of proinflammatory factors, suggesting that excess estrogen inactivation in WAT may predispose these individuals to the metabolic syndrome ( 10 ). (
  • We have new projects emerging for aging, dementia, and metabolic syndrome. (
  • Explain that several different studies demonstrated an association between psoriasis and metabolic syndrome, obesity, type 2 diabetes, or hypertension. (
  • PHOENIX -- Psoriasis increased the odds for metabolic syndrome by 40%, and the strength of the association grew with the severity of the skin disease, investigators reported here. (
  • Severe psoriasis doubled the likelihood of metabolic syndrome as compared with no history of psoriasis. (
  • Moreover, the prevalence of each component of metabolic syndrome increased with psoriasis severity, including obesity, hypertriglyceridemia, and elevated glucose, Sinead Langan, MD, of the London School of Hygiene and Tropical Medicine, reported at the Society for Investigative Dermatology meeting. (
  • The findings suggest that patients with psoriasis should be considered for enhanced screening for metabolic syndrome, Langan said. (
  • Several small clinic-based studies have shown an association between psoriasis and metabolic syndrome, which has well-documented links to diabetes and cardiovascular disease. (
  • The investigators defined metabolic syndrome by the National Cholesterol Education Program Adult Treatment Program III diagnostic criteria. (
  • Overall, patients with psoriasis had a 33.7% prevalence of metabolic syndrome compared with 25.9% in the control group. (
  • After adjustment for age, sex, and duration of follow-up, patients with psoriasis had a 1.41 odds ratio for metabolic syndrome compared with the control group (95% CI 1.31 to 1.51). (
  • An understanding of the contributions of different neuronal and non-neuronal cell types to hypothalamic inflammatory processes, and delineation of the differences and similarities between acute and chronic activation of these inflammatory pathways, will be critical for the development of novel therapeutic strategies for the treatment of obesity and metabolic syndrome. (
  • The finding that obesity and metabolic disorder are accompanied by chronic low-grade inflammation has fundamentally changed our view of the underlying causes and progression of obesity and metabolic syndrome. (
  • and therapeutic approaches to modulate inflammation in the context of obesity and metabolic syndrome. (
  • These Reviews also discuss how inflammation can lead to other aspects of metabolic syndrome, including hyperphagia, reduced energy expenditure, β cell dysfunction, and liver disease, and summarize the status of therapeutic interventions that target inflammation in the context of metabolic syndrome. (
  • Metabolic Syndrome is associated with sedentary lifestyle .It makes a person more prone to develop type 2 diabetes and coronary artery disease. (
  • Syndrome X" or "Metabolic syndrome" is a group of conditions that puts a person at risk for diabetes and heart disease. (
  • With Syndrome X, the risk of developing heart disease jumps twentyfold. (
  • Metabolic syndrome is an ever-increasing health problem among the world's population. (
  • TAG) level and severity of metabolic syndrome. (
  • Thus, controlling the synthesis of TAG will have a great impact on overall systemic lipid metabolism and thus metabolic syndrome progression. (
  • As research data, Laakso's group uses the METabolic Syndrome in Men (METSIM) study comprising more than 10,000 men living in eastern Finland. (
  • Alterations in gut microbiota composition and metabolic parameters after dietary intervention with barley beta glucans in patients with high risk for metabolic syndrome development. (
  • Metabolic syndrome is a complex disease that is exponentially increasing in the western world, and diet is one of the possible ways to improve the metabolic status of patients. (
  • Biological functional analysis of these proteins showed that they relate to, among others, cholesterol metabolism, immune mechanisms, blood clotting and other biological mechanisms known to be involved in metabolic diseases, also known as the metabolic syndrome. (
  • If these proteins could be validated in humans, these protein levels could therefore be used as an early warning system that metabolism is changing towards the metabolic syndrome and general unhealthy status. (
  • All of these symptoms, and the underlying processes behind these symptoms that we're seeing in these dragonflies, are pretty much identical to what you see in mammalian metabolic syndrome and obesity," said Marden. (
  • Metabolic syndrome is the name given to a group of symptoms that increase your risk for heart disease, diabetes, and stroke. (
  • A diet high in fat is one trigger for metabolic syndrome, as it contributes in many ways - potential weight gain, especially in the abdominal area, and increasing cholesterol levels, a risk factor for heart disease and stroke. (
  • New research suggests that a deficiency in Vitamin D may contribute to metabolic syndrome . (
  • Based on this study, we believe that keeping vitamin D levels high, either through sun exposure, diet or supplementation, is beneficial for prevention and treatment of metabolic syndrome," says Professor Pandol. (
  • You must have at least three metabolic risk factors to be diagnosed with metabolic syndrome. (
  • The prevalence of diet-induced metabolic diseases, including insulin resistance, type 2 diabetes (T2D), hypertension, cardiovascular disease, non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome, is rising rapidly worldwide, with obesity representing a major cause of these diseases ( Han and Lean, 2016 ). (
  • Recent studies show that mTOR pathway activation, glucose utilization, mitochondrial oxidative phosphorylation, and antioxidant defenses play critical roles in the pathogenesis of autoimmune diseases, including rheumatoid arthritis, immune thrombocytopenia, Sjögren's syndrome, large vessel vasculitis, and systemic lupus erythematosus. (
  • What is the role of metabolic syndrome in the etiology of fatty liver disease? (
  • The condition most commonly associated with fatty liver disease is metabolic syndrome. (
  • Diabetes, metabolic syndrome and dyslipidemia are common and rapidly increasing in Asia. (
  • The prevalence and incidence of metabolic diseases including diabetes, hypertension, metabolic syndrome, dislipidemia and osteoporosis will be observed. (
  • Does Metabolic Syndrome Exist? (
  • In a move that initially seems surprising, the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) released a joint statement questioning the utility of the term "metabolic syndrome," and discouraging doctors from using it. (
  • The two diabetes associationsobject to the use of the term "metabolic syndrome. (
  • Doctors, they say, should not try to treat this presumed disease as a whole, but should simply address each one of the risk factors encompassed by metabolic syndrome individually. (
  • They object to the use of metabolic syndrome as a specific target of therapy in clinical trials, such as those testing .com/od/dietandobesity/a/rimonabant6.htm"> rimonabant . (
  • The joint statement is very perplexing to the tens of thousands of doctors who have been trying to help their patients cope with metabolic syndrome. (
  • That way when going into a Dr.'s office, especially for the first time, if you told them that you had Metabolic Syndrome, they would now what to address. (
  • Lo and behold, just a few weeks ago there was an article about the ADA questioning the existence of Metabolic Syndrome and discouraging doctors from using this terminology. (
  • Now, the AHA and the NHLBI have released a new statement on the importance of metabolic syndrome. (
  • The new statement adjusts the criteria for diagnosing metabolic syndrome slightly (mainly in light of new guidelines for treating cholesterol. (
  • But its main point is to reemphasize the importance of metabolic syndrome and its treatment. (
  • Metabolic syndrome, (also known as syndrome X), is characterized by a cluster of risk factors that come together to predispose a person to cardiovascular disease and diabetes, increasing the risk for heart attacks and strokes. (
  • The dominant underlying risk factors for the development of metabolic syndrome are abdominal obesity and insulin resistance. (
  • Blood sugar levels of people with metabolic syndrome are not high enough to qualify as diabetes. (
  • About 50 million Americans are believed to have metabolic syndrome. (
  • The incidence of metabolic syndrome increases significantly after age 50, with Hispanics and Asians more frequently effected. (
  • In many cases, early onset metabolic syndrome can be successfully treated without medication. (
  • Weight loss, a healthy diet, regular exercise, and smoking cessation are potently effective in improving the various components of metabolic syndrome. (
  • 4 The Centers for Disease Control and Prevention estimated that eliminating 3 risk factors-poor diet, inactivity, and smoking-would prevent 80% of heart disease and stroke cases, 80% of type 2 diabetes mellitus cases, and 40% of cancer cases. (
  • 5 Chronic diseases and conditions such as cardiovascular disease, stroke, cancer, type 2 diabetes, obesity, and arthritis are among the most costly and preventable of all health problems. (
  • There is growing evidence that any modification in the microbiota composition can lead to several diseases, including metabolic diseases, such as obesity and diabetes, and cardiovascular diseases. (
  • The relationship between heart disease and type 2 diabetes has become so interrelated now, that some experts in the field are even suggesting the creation of a new specialty: "cardiabetes. (
  • A study by researchers at Yale has uncovered why belly fat surrounding organs increases as people age, a finding that could offer new treatment possibilities for improving metabolic health, thereby reducing the likelihood for diseases like diabetes and atherosclerosis that stem from inflammation. (
  • The AMP-activated protein kinase (AMPK) is a central regulator of multiple metabolic pathways and may have therapeutic importance for treating obesity, insulin resistance, type 2 diabetes (T2D), non-alcoholic fatty liver disease (NAFLD), and cardiovascular disease (CVD). (
  • Melbourne researchers have uncovered important differences between the male and female immune system which may explain why men are more susceptible to obesity and metabolism-related associated diseases, such as heart disease, stroke and diabetes. (
  • Students will evaluate the pathophysiology and functional consequences of metabolic conditions including obesity, dyslipidaemias, impaired glucose tolerance and diabetes mellitus. (
  • Metabolism shapes risks for a lot of different diseases, including obesity, type 2 diabetes, cancer and Alzheimer's disease. (
  • There are currently over 1.9 billion people who are obese or overweight, leading to a rise in related health complications, including insulin resistance, type 2 diabetes, cardiovascular disease, liver disease, cancer, and neurodegeneration. (
  • Pathological protein clumps are characteristic of a series of diseases, such as Alzheimer's disease, Parkinson's disease, and type 2 diabetes. (
  • Fraunhofer researchers are investigating the potential of microimplants to stimulate nerve cells and treat chronic conditions like asthma, diabetes, or Parkinson's disease. (
  • An altered gut microbiota has been associated with several diseases, including obesity and diabetes, but the mechanisms involved remain elusive. (
  • It is a group of intertwined maladies that includes obesity, hypertriglyceridemia, hypertension, nonalcoholic fatty liver disease (NAFLD), and diabetes mellitus type II (T2D). (
  • What type 2 diabetes and cardiovascular diseases have in common is the fact that they are becoming increasingly widespread due to the prevalence of unhealthy lifestyle habits and the population's ageing and weight gain. (
  • These diseases often go hand in hand, making each other worse: 75% of persons with diabetes die of cardiovascular diseases. (
  • Furthermore, the investigators aim to identify new genetic and non-genetic biomarkers for type 2 diabetes, insulin resistance and coronary artery disease. (
  • Type 1 diabetes is an example of a metabolic disease. (
  • Researchers at Duke University have identified a protein that may help determine whether a person will develop an apple- or pear-shaped body, which could point to his or her risk of diabetes or heart disease. (
  • Fat concentration in the midsection is thought to induce inflammation and trigger metabolic diseases including high blood pressure, stroke and diabetes. (
  • When they gave the fish glucose, the genetically modified fish also cleared sugar from their bloodstream more efficiently, which in humans points to a reduced risk of diabetes and heart disease. (
  • Metabolic disturbances are a major cause of chronic diseases including obesity, diabetes, atherosclerosis, and hypertension, thereby increasing health insurance costs and early death of patients. (
  • An increasing proportion of the western population suffers from diet-induced metabolic and endocrine abnormalities causing diseases like obesity, diabetes, atherosclerosis, high blood pressure, heart problems, and cardio-vascular diseases. (
  • William T. Cefalu, MD, has been appointed the new director of the Division of Diabetes, Endocrinology, and Metabolic Diseases (DEM) at the NIDDK. (
  • His clinical and basic science research has focused on interventions to improve the metabolic state of people with insulin resistance and type 2 diabetes, and on the cellular mechanisms for insulin resistance. (
  • The NIDDK looks forward to Dr. Cefalu bringing his scientific expertise, physician experience, and leadership in the diabetes community to his new role, promoting the mission of the NIDDK Division of Diabetes, Endocrinology, and Metabolic Diseases. (
  • Aging is the most universal contributor to the aetiologies of metabolic decline and related diseases, including type 2 diabetes mellitus, cardiovascular disease, non-alcoholic steatohepatitis (NASH), stroke, neurodegenerative diseases, and cancer. (
  • According to the Centers for Disease Control and Prevention, 37 percent of adults living in the United States are obese and at higher risk of developing heart disease, stroke, type 2 diabetes and cancer. (
  • It also supports the suggestion that having the ability to increase the number of fat cells in the lower body affords some protection to the upper body, thus lessening the risk of developing metabolic disease, which can lead to diabetes and other health problems. (
  • The work could lead to new treatments that target common metabolic maladies such as high cholesterol and diabetes as well as hemolytic anemia, which occurs when red blood cells break down prematurely. (
  • These combined effects of insulin resistance increase an individual's risk for heart disease, stroke, diabetes and other conditions. (
  • The traditionally held view or dogma is that cancer is a genetic disease, but what Warburg discovered is that cancer is really caused by a defect in the cellular energy metabolism of the cell, primarily related to the function of the mitochondria, which are the little power stations within each cell. (
  • If defective mitochondria are responsible for the origin of cancer, and defective energy metabolism is responsible for the majority of the phenotypes, i.e., the observable characteristics of the disease that you see, then how do you treat the disease? (
  • The Metabolic Clinic consists of a multidisciplinary team dedicated to providing care to children with known or suspected inborn errors of metabolism. (
  • Babies who have abnormal newborn screens and go on to be diagnosed with an inborn error of metabolism receive follow up and long term care in the Metabolic Clinic. (
  • The Metabolism Clinic physicians are available for inpatient and outpatient consultations for physicians with diagnostic or management concerns related to metabolic diseases. (
  • The Metabolic Clinic consists of a team of specialists dedicated to working with families to provide on-going management recommendations and support for treatment of inborn errors of metabolism. (
  • The Metabolic Clinic provides genetic counseling and education related to inborn errors of metabolism. (
  • In this review we evaluate the metabolic phenotypes of transgenic mouse models in which AMPK expression and function have been manipulated, and the impact this has on controlling lipid metabolism, glucose homeostasis, and inflammation. (
  • Also searched for Adrenoleukodystrophy , Metabolic Disease , Metabolism and more. (
  • Here we review the biology of fructose metabolism as well as potential mechanisms by which excessive fructose consumption may contribute to cardiometabolic disease. (
  • Since obesity and metabolism shape risks for so many different diseases, the discovery of these parts of the genome is a really exciting insight that lays foundations for many important new research directions," Gregg says. (
  • The Molecular Metabolism and Metabolic Diseases (3MD) Track is designed to deepen students' understanding of biological processes and molecular mechanisms underlying metabolic diseases. (
  • Research at UT Southwestern in metabolism and metabolic diseases is renowned and has been led by some of the country's most respected investigators. (
  • The mission of the Track is to prepare graduate students to conduct cutting-edge basic science research on the biological processes underlying metabolism and the metabolic drivers of disease. (
  • The Molecular Metabolism and Metabolic Diseases (3MD) Track at UT Southwestern is designed with metabolism in mind. (
  • In addition to metabolic derangements in peripheral organs, obesity-related inflammatory changes perturb brain function, especially affecting brain areas that regulate energy homeostasis and systemic metabolism. (
  • Furthermore, the gut microbiota affect xenobiotic metabolism, bone mineral density, behavior, and several metabolic functions ( 5 , 6 ), and emerging data from humans and mouse models suggest that the gut microbiota play a role in the development of metabolic diseases. (
  • The group has also been involved in the discovery of several gene variants relating to overweight, disturbed lipid metabolism, blood pressure and coronary artery disease. (
  • A metabolic disease is any condition that disrupts your body's ability to convert food to energy (your metabolism). (
  • More specifically, we focus on the implications of mitochondrial fusion or mitochondrial fission proteins in age-related diseases, and the role of interplay between autophagy, mitochondrial function, and energy metabolism. (
  • Indeed, adverse events during prenatal life may result in permanent changes in the physiology and metabolism of the offspring, which in turn lead to programming and an increased risk of a variety of metabolic diseases. (
  • provide evidence of the epigenetic regulation (mainly DNA methylation and microRNAs) of the developmental programming of metabolism that may be related to the insurgence of cardiometabolic disease. (
  • Through this collaboration, we can be better equipped to find solutions for metabolic diseases that affect millions worldwide and are inadequately treated with current therapies," said Jerrold Olefsky, MD, associate dean for scientific affairs at UC San Diego School of Medicine and professor of medicine in the Division of Endocrinology and Metabolism. (
  • Olfactory receptors, responsible for perception of smell in our noses, have a role to play in glucose and fat metabolism as well, and could open up novel therapeutic possibilities for these diseases. (
  • Finally , brain metabolism differs between both AD subtypes as well, where EOAD indicates the wide spread damage and metabolic breakdown across more diverse regions of the brain. (
  • Cancer and metabolism The book looks at cancer as a metabolic disease. (
  • Targeting energy metabolism with metabolic therapy produces a therapeutic effect in ALS micewhich may prolong survival and quality of life in ALS patients. (
  • those whose mother (but not father) had the disease also show reduced glucose metabolism and cognitive function , as well as elevated PIB uptake (a marker of amyloid) and brain atrophy . (
  • In this review, we summarize metabolic alterations in aging brain and AD-related metabolic deficits associated with glucose metabolism dysregulation, glycolysis dysfunction, tricarboxylic acid (TCA) cycle, oxidative phosphorylation (OXPHOS) deficits, and pentose phosphate pathway impairment. (
  • Using the HOMA Index and the overnight metabolic profile, the authors could demonstrate a change in the indexes of insulin resistance, a deep involvement of the hypothalamic-endocrine axis and an increase of the inflammatory cytokines in the most severe OSAS patients. (
  • Neuronal inflammation and the subsequent insulin and leptin resistance of ARC neurons disrupts this metabolic feedback loop, further promoting increased food intake and body weight gain. (
  • Transgenic and pharmacological studies in mice have demonstrated the beneficial effects of MGAT inhibition as a therapy for treating several metabolic diseases, including obesity, insulin resistance, T2D, and NAFLD. (
  • see the Perspective by Ferrante) found that the mice were protected against many of the diet-induced metabolic changes, including insulin resistance, despite similar weight gain as control mice on a high-fat diet. (
  • They are conducting a full metabolic assessment of the cells "to determine whether the cells in the offspring of obese moms display inflammation, insulin resistance or other metabolic differences," the release said. (
  • Dr. Taesun Park of Yonsei University, Korea, who has been part of some fascinating recent research on olfactory receptors throughout our body, and has led a recent study that implicates one such receptor as a drug target for treating high fat induced metabolic diseases like insulin resistance. (
  • our findings reveal, for the first time, a novel function of MOR23 in regulating obesity-related metabolic diseases such as insulin resistance as well as ɑ-cedrene as a specific activating molecule for this receptor. (
  • Learn about the cellular, molecular, and biochemical pathways of CRISPR-associated proteins, DNA repair pathways, and applications in diverse organisms, including for human health and disease biology. (
  • Researchers unveil the most comprehensive atlas of genes underlying human metabolic pathways, paving the way for improved understanding and treatment of metabolic diseases. (
  • Here, we highlight recent advances in the role of proinflammatory metabolic pathways in autoimmune disease, including treatment with antioxidants and mechanistic target of rapamycin (mTOR) inhibitors. (
  • But ɑ-cedrene does not act via the common pathways known to improve obesity-induced metabolic diseases. (
  • However, the true value of such advances requires a 'Systems' approach that can be provided by Metabolic Engineering, through its ability to characterize metabolic pathways composed of a constellation of different enzymes. (
  • NF-κB, inflammation, and metabolic disease. (
  • It is now widely appreciated that chronic low-grade inflammation plays a key role in the initiation, propagation, and development of metabolic diseases. (
  • Consistent with its central role in coordinating inflammatory responses, numerous recent studies have implicated the transcription factor NF-κB in the development of such diseases, thereby further establishing inflammation as a critical factor in their etiology and offering hope for the development of new therapeutic approaches for their treatment. (
  • In addition, factors involved in the progression of NAFLD, such as inflammation and fibrogenesis, represent common pathophenotypes implicated in the progression of complex systemic diseases. (
  • The nature of obesity-induced inflammation differs from other inflammatory paradigms in that it involves tonic activation of the innate immune system that impacts metabolic homeostasis, in some cases over a lifetime. (
  • These features of obesity-induced inflammation present a challenge to understanding the underlying mechanisms and the manner by which they impact metabolic systems. (
  • In this issue of the JCI , a group of experts have provided reviews that dive deeply into the mechanisms by which obesity-induced inflammation influences metabolic homeostasis, surveying the modes and mechanisms of inflammation in different tissues and how they might contribute to disease. (
  • A kinase in macrophages is required for high-fat diet-induced metabolic changes and inflammation. (
  • Additionally, an estimated 3 to 12 percent of adults have NASH -- a more severe type of non-alcoholic fatty liver disease (NAFLD) that includes fat accumulation, liver inflammation and liver damage, increasing potential risk for cirrhosis. (
  • The causes of the microbiota alterations and the mechanisms by which microbiota modifications can act on the development of metabolic and cardiovascular diseases have been reported. (
  • Cardiovascular diseases are one of the major causes of deaths in adults in the western world. (
  • WHO has predicted that, by 2030, cardiovascular diseases will remain the leading causes of death, affecting approximately 23.6 million people around the world [ 2 ]. (
  • The shared list of genes/proteins was enriched in drug targets for anti-inflammatory therapy, drugs used to treat cardiovascular diseases, antimicrobial agents and phytochemicals, among many other approved pharmaceutical compounds. (
  • Diseases such as cardiovascular diseases, cancer or certain lung diseases are among the most common non-natural causes of death today and account for about 70 percent of deaths worldwide. (
  • Cardiovascular diseases have been studied for a long time, yet we keep finding new approaches to their treatment," Ylä-Herttuala says. (
  • cardiovascular diseases in epidemiological studies, although the mechanisms of this association are unclear. (
  • Cardiovascular diseases remain among the leading causes of death in the western world. (
  • NIEHS research uses state-of-the-art science and technology to investigate the interplay between environmental exposures, human biology, genetics, and common diseases to help prevent disease and improve human health. (
  • This work identifies a new molecular pathway that determines how fat is stored in the body, and as a result, affects overall metabolic health,' senior study author John F. Rawls, associate professor of molecular genetics and microbiology at Duke University School of Medicine, said in the news release. (
  • Metabolic Brain Disease serves as a forum for the publication of outstanding basic and clinical papers on brain diseases, including both human and animal studies. (
  • Several animal and clinical trials have shown a positive association between cholesterol levels and the risks of coronary heart disease. (
  • PHILADELPHIA - A newly discovered biomarker associated with a rare metabolic disorder may facilitate better diagnosis and identification of new drugs for clinical trials for the disease, according to researchers in the Perelman School of Medicine at the University of Pennsylvania. (
  • These studies suggest CSF spermine could be used as a biomarker to evaluate the outcome of novel therapeutics designed to treat the CNS manifestations of MPS diseases, which will greatly simplify clinical trials. (
  • Here, we review the evidence that environmental influences during mammalian development lead to stable changes in the epigenome that alter the individual's susceptibility to chronic metabolic and cardiovascular disease, and discuss the clinical implications. (
  • This unit aims to develop the clinical decision making processes, knowledge and skills necessary for effective assessment and treatment of patients with metabolic conditions. (
  • I think it's remarkable how many scientific papers have come out at this meeting looking at psoriasis and cardiovascular disease, metabolic comorbidities, something like 13 abstracts, from the basic level to the clinical level, linking psoriasis to these outcomes in some direct manner," Gelfand told MedPage Today . (
  • Patient support is provided by two clinical nurse specialists, research nurses, a clinical psychologist, four metabolic dietitians, a dietetic assistant and administrative staff. (
  • Developed by his group, gene therapy for severe coronary artery disease has already been tested in clinical trials led by Professor Juha Hartikainen at Kuopio University Hospital. (
  • With contributions from noted experts, the text explores basic biological factors of healthy development and disease states and makes the information accessible for clinical interventions. (
  • However, before the clinical symptoms of disease become apparent, there is often a subclinical period which may last for many years. (
  • Predictors reflecting the pathological severity of non-alcoholic fatty liver disease: comprehensive study of clinical and immunohistochemical findings in younger Asian patients. (
  • Alexander J, Torbenson M, Wu TT, Yeh MM. Non-alcoholic fatty liver disease contributes to hepatocarcinogenesis in non-cirrhotic liver: a clinical and pathological study. (
  • These two Durango-based health professionals have combined their clinical experience with current research to co-author a book on how diet and lifestyle can prevent or heal chronic disease. (
  • Cancer is a metabolic disease, not a genetic one. (
  • A dogma is considered irrefutable truth, and that cancer is a genetic disease is, no question, a dogma. (
  • All of the major college textbooks talk about cancer as a genetic disease. (
  • and] if cancer is a genetic disease, everything flows from that concept. (
  • Therefore we must maintain ourselves on the established track that all of this metabolic stuff could be resolved if we just understood more about the genetic underpinning of the disease. (
  • This team includes metabolic physicians, genetic counselors, a metabolic dietitian and a metabolic social worker. (
  • In the future, genetic engineering is expected to provide effective molecular therapy for the countless diseases currently termed 'metabolic' or 'degenerative. (
  • Hereditary hemochromatosis , also called iron overload disease, is genetic disorder in which the body absorbs and stores too much iron. (
  • Alpha-I antitrypsin deficiency (AATD) is a rare genetic condition that often causes emphysema in adults and/or liver disease at any age. (
  • Wilson Disease is a rare genetic disease in which copper accumulates in the liver, brain, eyes and other organs. (
  • Case-finding in the neonatal period facilitates early inauguration of therapy, genetic counseling, and improved understanding of the natural history and incidence of metabolic diseases. (
  • If patients have genetic mutations, do they have metabolic dysfunction? (
  • This work fits within the frame of two really big health problems worldwide: increased prevalence of genetic disease predispositions, and obesity," says Costa. (
  • Cystathionine-β-synthase (CBS) deficiency is a human genetic disease causing homocystinuria, thrombosis, mental retardation, and a suite of other devastating manifestations. (
  • Production of the critical antioxidant glutathione through the CBS pathway was greatly decreased when CBS function was restricted through genetic, cofactor, or substrate restriction, a metabolic consequence with implications for treatment. (
  • Homocystinuria, elevated levels of the sulfur-containing metabolite homocystine in the urine, illustrates several challenges inherent to elucidating the molecular bases of human genetic diseases. (
  • The genetic basis linking EOAD and LOAD has been the apolipoprotein E gene (APOE) to indicate metabolic alteration with the ε 4 allele specifically. (
  • its activity is reduced not just in those with Alzheimer's , but even in asymptomatic individuals who are at genetic risk for the disease or had a mother with Alzheimer's . (
  • For example, genetic or hereditary hypophosphatemia may cause the metabolic bone disorder osteomalacia. (
  • Although there is currently no treatment for the genetic condition, replacement of phosphate often corrects or improves the metabolic bone disorder. (
  • The clinic provides diagnostic evaluations of children, age's birth to 18 years, in whom a metabolic disorder is considered. (
  • Metabolic and Degenerative Diseases of the Central Nervous System is a comprehensive reference work that provides the neuroscience community with valuable, current, and scholarly summaries on every known degenerative disorder. (
  • however, neither of these treatments cure the disorder, especially when the disease enters the central nervous system. (
  • Thus, these are some of the best signs of metabolic disorder in older dogs. (
  • A dog's behavior can also tell you a lot about their general health and if they are suffering from a metabolic disorder. (
  • If your vet suspects a metabolic disorder, they may refer you to a veterinary specialist or a specialty group. (
  • New research on mouse model (Gcdh-/- mice) by William Zinnanti and colleagues at Penn State, Hershey, has provided insight into the mechanisms underlying injury and age-dependent susceptibility to Glutaric acidemia type I (GA-I), an inherited disorder similar to Huntington disease. (
  • The observation means that increasing dietary fat intake could ease some sufferer's symptoms, or using drugs which stressed the mitochondria could activate beneficial metabolic shift in patients living with a metabolic disorder. (
  • Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig's disease, is a neurodegenerative disorder of motor neurons causing progressive muscle weakness, paralysis, and eventual death from respiratory failure. (
  • Fructose intolerance is a metabolic disorder with hereditary determinism, clinically manifested on terms of fructose intake. (
  • In my view, this information is the game changer that not only treats cancer but virtually every single disease known to man, because at the core of most serious ailments you find mitochondrial dysfunction. (
  • The discovery expands the known taxonomic breadth of metabolic disease and suggests that the study of microbes found in human intestines may provide a greater understanding of the root causes of human metabolic dysfunction. (
  • James Marden, professor of biology and an insect physiologist at Penn State, and Ruud Schilder, who in August 2006 earned his doctorate in biology at Penn State and is now a postdoctoral fellow at the University of Nebraska, are the first to show a non-mammalian species suffering from metabolic dysfunction in ways similar to humans. (
  • Mitochondrial dysfunction has been reported in complex age-related diseases, as well as in aging itself. (
  • These observations thus support the notion that mitochondrial dysfunction and the accumulation of oxidative damage contribute to the pathogenesis of these diseases. (
  • Griffith, J. and Kelly-Worden, M. (2018) Early-Onset Alzheimer's Disease and Metabolic Dysfunction, a Comparative Review. (
  • Its proponents posit that mitochondrial dysfunction lies at the heart of neural degeneration, driven by metabolic abnormalities which lead to classic Alzheimer's pathology. (
  • So if mitochondrial dysfunction initiates the Alzheimer's cascade, what are the steps leading from metabolic disruption to neurodegeneration and ultimately, dementia? (
  • Based in the Department of Endocrinology, the Metabolic Bone Disease & Endocrine Calcium Center provides superior access to a multidisciplinary team, providing Center-of-Excellence DXA bone density testing and interpretation, on-site laboratory testing, and a fully staffed infusion center for even the most sophisticated testing and drug administration requirements. (
  • It's become more common in people of all ages, including children, but older adults are especially at risk because they're also more prone to weight gain and developing chronic diseases such as hypertension as they age," Bruemmer notes. (
  • As a result, scientists don't fully understand the interactions between the disease and other environmental and lifestyle factors such as stress, hypertension, and obesity over the course of adulthood. (
  • Te Pas M.F.W., S-J. Koopmans, L. Kruijt, S. Boeren, M.A. Smits (2018) Changes in Plasma Protein Expression Indicative of Early Diet-induced Metabolic Disease in Male Pigs (Sus scrofa) . (
  • The Metabolic Bone Disease & Endocrine Calcium Center team has partnered with their highly skilled Endocrine Surgery colleagues to provide timely, integrated assessment of parathyroid abnormalities with ultrasonography, direct laryngoscopy, and other state of the art testing. (
  • The Metabolic Bone Disease & Endocrine Calcium Center and the Department of Endocrine Surgery continue to collaborate to provide comprehensive pre-surgical assessment, timely surgical intervention, and post-surgical follow up for all patients with parathyroid disease in their care. (
  • The Metabolic Bone Disease & Endocrine Calcium Center addresses problems associated with the regulation of the body's bone, mineral and hormone functions. (
  • Researchers also observed that those without the gene had visceral fat tissue composed of smaller but more numerous cells- a factor known to reduce the risk of metabolic disease in humans- compared to the fish that still had the gene. (
  • Pigs are a good model animal for humans because humans and pigs show high similarity among nutritional, metabolic and physiological mechanisms. (
  • Metabolic disease isn't some strange thing having just to do with humans," said Marden. (
  • Detection of early-onset changes related to metabolic syndromes might help to prevent progression of the disease or to enable the initiation of interventions at an early stage of disease. (
  • That's what we've been doing for the last 20 years: simply decreasing the slope of the progression of the disease," says Costa. (
  • Metabolic Therapy with Deanna Protocol Supplementation Delays Disease Progression and Extends Survival in Amyotrophic Lateral Sclerosis (ALS) Mouse Model. (
  • The pathological metabolic alterations in aging (e.g., cerebral glucose hypometabolism) are early and consistent events in the progression of AD. (
  • Learn about the latest research breakthroughs in the fight against Alzheimer's, cancer and other devastating diseases. (
  • Alzheimer's disease is quickly becoming one of the most known diseases in the country due to its devastating effects and lack of treatment options. (
  • Within this lethal disease, there is a smaller group, those individuals that are diagnosed with early-onset Alzheimer's disease. (
  • The topographical atrophy disparities between EOAD and LOAD supported the more noticeable cognitive differences between the two Alzheimer's disease categories. (
  • Advances in Alzheimer's Disease , 7 , 1-11. (
  • In late-onset Alzheimer's disease (LOAD), adults over the age of 65 show the characteristic decline in memory function and some mood swings. (
  • When the hallmarks of Alzheimer's disease are viewed: Amyloid Beta (Aβ) plaque and tau tangles, the EOAD and LOAD patients differ still. (
  • The Mitochondrial Hypothesis: Is Alzheimer's a Metabolic Disease? (
  • Despite decades of research devoted to understanding its origins, Alzheimer's disease remains a daunting and devastating neurological mystery, ranking as the sixth leading killer of Americans. (
  • A common thread across many of these drugs is their targeting the defining marker of the disease, amyloid plaques - those nasty extracellular deposits of beta-amyloid protein that invariably present in the Alzheimer's brain and are thought to be toxic to neurons. (
  • For the mitochondrial theory to hold water, it must critically account for the classic pathological markers that define Alzheimer's and have shaped traditional disease models - namely, amyloid plaques, tau tangles and brain atrophy. (
  • Alzheimer's disease (AD) is an incurable neurodegenerative disease. (
  • Alzheimer's disease (AD) is an age-related neurodegenerative disease characterized by a progressive loss of neuronal structure and function. (
  • Background Non-alcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease worldwide. (
  • Nonalcoholic fatty liver disease (NAFLD) affects over 40% of American adults and is due in part to physical inactivity and obesity. (
  • The clinicopathological profile of Indian patients with nonalcoholic fatty liver disease (NAFLD) is different from that in the West. (
  • Following is a rerun of this popular and important article and interview with Seyfried, in which we discuss his book, "Cancer as a Metabolic Disease" - an important contribution to the field of how cancer starts and can be treated. (
  • His book, " Cancer as a Metabolic Disease " is an important contribution to the field of how cancer starts and can be treated. (
  • The present paper reviews the mechanisms of action of anti-cholesterolemic potential of probiotic microorganisms and probiotic food products, with the aim of lowering the risks of cardiovascular and coronary heart diseases. (
  • Laakso's research group has been involved in the discovery of nearly all of them, shaping our understanding of the mechanisms of the disease. (
  • Whether dietary habits or specific nutrients during prenatal and postnatal life may trigger specific epigenetic mechanisms, which in turn are involved in the development of disease phenotypes, has not yet been fully established. (
  • In the first year of the partnership, nine projects will be initiated focusing on the development of animal and cell models of NASH and CKD, as well as the discovery of mechanisms invoked by bariatric surgery, disease-related biomarkers and novel therapeutic targets. (
  • In the case of endocarditis, histopathology can contribute to determining the etiology of the disease and identifying bacterial ulcerative endocarditis, possibly with septic microembolisms. (
  • Do you have a question about diet-induced metabolic diseases? (
  • In this Research Topic, we present a series of both review articles and original research manuscripts that illuminate the role and effects of epigenetic modifications occurring in diet-induced metabolic diseases. (
  • Examples of such abnormalities are dietary deficiency and gastrointestinal, liver, kidney, and hormonal diseases. (
  • Changes in bone tissue due to metabolic abnormalities are classified with regard to the amount and composition of the bone tissue. (
  • Additionally, metabolic abnormalities associated with obesity, bariatric surgery and organ transplantation are diagnosed and treated. (
  • This finding begs the question of whether something similar might be happening in human metabolic diseases, the root causes of which remain poorly understood despite intense study. (
  • Sure, it is just on a computer but a new reconstruction of human metabolic activity, created by researchers at the University of California, San Diego, could revolutionize the study of how the body breaks down food into energy and assembles hormones and proteins to power biological processes crucial to daily life. (
  • The result," he says, "is the first comprehensive reconstruction of the human metabolic map that is biochemically, genetically and genomically accurate or structured. (
  • This new biomarker for CNS symptoms in MPS patients may help families better understand their child's diagnosis and prognosis and should help clinicians and regulatory agencies to evaluate the efficacy of new therapies," said senior author James Wilson, MD, PhD, a professor of Medicine and director of the Orphan Disease Center (ODC) at Penn. (
  • Diagnosis and therapy is available for children with inborn and acquired kidney and liver diseases. (
  • The information should not be used for either diagnosis or treatment or both for any health related problem or disease. (
  • The Metabolic Clinic staff evaluates patients with a history concerning for a metabolic disease. (
  • We are currently exploring it as a new target for therapies that might work in patients with diseases like psoriasis and multiple sclerosis, where treatment options are limited. (
  • In MPS I patients, elevated CSF spermine was restricted to patients with genotypes associated with CNS disease. (
  • We are offering access to this biomarker to the orphan disease research community for all research purposes at no cost to enable labs to freely conduct assays for their own research and patients' needs. (
  • At present the disease is only found in half of the expected number of patients. (
  • The number of patients can be predicted based on the presence of changes in the DNA, so called gene mutations, which can cause the disease. (
  • Therefore the disease was not discovered in more than half of the patients. (
  • The patients with psoriasis were grouped according to disease severity. (
  • There were 2,044 of the psoriasis patients who had mild disease, 1,377 with moderate disease, and 475 with severe psoriasis. (
  • This is the basic step that is blocked in our patients, and the disease is the result. (
  • We have a purpose-built metabolic diet kitchen to support treatment and education of patients. (
  • We see patients with a range of LSDs including Fabry disease, Pompe disease, Gaucher disease, Niemann-Pick diseases, mucolipidoses and the mucopolysaccharidoses. (
  • For many conditions, disease modifying treatments are available, and all patients are offered regular review and symptomatic treatment. (
  • Researchers at the Salk Institute found a diet high in fat may provide benefits for human patients suffering with mitochondrial disease. (
  • The Metabolic Bone Diseases Clinic at Tufts Medical Center provides cutting edge care to patients with osteoporosis, hyperparathyroidism, and other conditions that weaken bones. (
  • Additionally, we work closely with other Departments to provide care for patients who have complex metabolic bone disease. (
  • The HSS Metabolic Bone Disease Fellowship is designed to provide the participant with an ongoing, in-depth experience in the medical management of patients with metabolic bone disease. (
  • Guidelines provided by the Department of Health and Human Services, American College of Sports Medicine, and the American Association or the Study of Liver Diseases state that all patients with fatty liver should get at least 150 minutes of moderate-intensity physical activity each week. (
  • Researchers will also evaluate biological samples obtained from patients with various diseases using UC San Diego's core capabilities in high-throughput metabolomics, microbiome research and bioinformatics. (
  • Procoagulant imbalance in patients with non-alcoholic fatty liver disease. (
  • Due to the previously mentioned differences in symptomology and presentation of the disease state, this paper will look to see if there is a difference in metabolic dysfunctions in EOAD patients as compared to LOAD patients. (
  • The Metabolic Approach to Cancer: Integrating Deep Nutrition, the Ketogenic Diet, and Non-Toxic Bio-individualized Therapies, from Chelsea Green Publishing, was created as a guide for not only cancer patients and survivors but for anyone facing chronic disease. (
  • Our facilities allow our experts to perform specialized testing not found in most medical centers, and patients are provided access to a wide variety of therapies using the most up to date medications to diagnose and treat both common and rare bone diseases. (
  • The Deanna Protocol (DP) is a metabolic therapy that has been reported to alleviate symptoms in patients with ALS. (
  • 11. Sachs M, Asskali F, Encke A, Förster H. Metabolic changes in patients with hereditary fructose intolerance. (
  • We have also demonstrated that Mfn2 deficiency causes a chronic Unfolded Protein Response (UPR), which is crucial in the metabolic alterations associated with this condition. (
  • The same article also mentions the possibility of the ε4 allele being linked to metabolic alterations within the brain. (
  • If no screening tests are available or the disease is not detected on screening test, symptoms develop. (
  • Certain symptoms, though, are important indications of metabolic problems. (
  • If children with GA-I reach 5 years of age without suffering brain injury they usually never show symptoms of the disease. (
  • Symptoms vary widely depending on the type of metabolic disease. (
  • Treatment of metabolic risk factors in order to prevent cardiovascular disease requires an enduring approach with multiple drugs, which can be associated with considerable costs, side effects, and a low rate of therapeutic compliance due to lack of symptoms until later stages of the disease. (
  • A few well-characterized alleles of the gene encoding cystathionine β-synthase ( CBS ) correlate with disease symptoms, providing an appealing molecular mechanism. (
  • Both events occur early in the disease process, even before individuals show any symptoms of cognitive impairment. (
  • The work identifies PKM2 as a potential therapeutic target for treating a host of diseases mediated by over-active immune cells, such as psoriasis and multiple sclerosis. (
  • AMPK as a Therapeutic Target for Treating Metabolic Diseases. (
  • These findings place ɑ-cedrene as a novel therapeutic approach to these metabolic diseases and MOR23 as a novel therapeutic target. (
  • It is widely believed that this reduction in lifespan is caused by metabolic defects. (
  • Additionally, we discuss recent treatment strategies targeting metabolic defects in AD, including their limitations, in an effort to encourage the development of novel therapeutic strategies. (
  • In addition, osteoporosis (age-related loss of bone with tendency to fractures) is traditionally included among the metabolic conditions even though its cause is not known. (
  • These terms do not imply any specific disease but simply describe the amount of bone present. (
  • Widespread but hardly ever truly generalized, osteosclerosis occurs in osteopetrosis ( marble bone disease ) and in Paget disease . (
  • These images are a random sampling from a Bing search on the term "Metabolic Bone Disease Following ICU Admission. (
  • Our doctors use a wide range of advanced diagnostic techniques to uncover what is causing your bone and/or mineral disease. (
  • Our doctors often recommend cutting edge diet and lifestyle changes to effectively treat many bone and related diseases. (
  • Throughout your time in our care, the doctors of the Metabolic Bone Diseases Clinic will take the time to get to know you so that they can tailor treatment strategies to your needs and lifestyle. (
  • The Metabolic Bone Disease Fellowship program within the combined orthopaedic, medical and radiology bone consortium represents the continued commitment of Hospital for Special Surgery to train clinicians and scientists in basic and applied research. (
  • Previous training for the Metabolic Bone Disease Fellowship includes all medical residencies and fellowships, physical medicine and rehabilitation, radiology, pathology and orthopaedic surgery. (
  • Each fellow will cover the monthly Metabolic Bone Disease Clinic, the weekly Metabolic Bone Disease Conference and the weekly Osteoporosis Patient sign-out. (
  • The Metabolic Bone Disease Fellows are the primary surgeons on service cases under the supervision of the attending staff and are the primary assistants to the attending physician on private operative cases. (
  • osteoporosis osteomalacia (adults) & rickets (children) osteitis fibrosa cystica Paget's disease of bone pyramiding (turtles) Osteoporosis is due to causal factors like atrophy of disuse and gonadal deficiency. (
  • Aufderheide A, Henke B, Parker E (1981) Granulomatous coronary arteritis (Takayasu disease). (
  • Although cholesterol is an important basic block for body tissues, elevated blood cholesterol is a well-known major risk factor for coronary heart diseases [ 1 ]. (
  • Could the patient's own genes be activated to combat coronary artery disease? (
  • At the moment, they are working on the sequencing of the entire genome of the METSIM data, seeking to discover new gene variants associated with early onset coronary artery disease. (
  • The microbiota plays a major role in many metabolic functions, including modulation of glucose and lipid homeostasis, regulation of satiety, production of energy and vitamins. (
  • Thus, it is reasonable to assume that although men have lower circulating estrogen concentrations than premenopausal women, aromatization of circulating androgen to estrogen in target metabolic tissues equilibrates cellular estrogen concentrations, and ER activation is critical in both sexes in promoting fuel homeostasis ( 5 ). (
  • A study reported in the Proceedings of the National Academy of Sciences investigated mice populations born with thousands of mutations in their mitochondrial DNA, and revealed how a hormone normally associated with longevity may aid in metabolic homeostasis in early years. (
  • Current and future preventive and therapeutic strategies to prevent these diseases by an adequate modulation of the microbiota have been also discussed. (
  • Here, we will review factors that affect the gut microbiota, how the gut microbiota may contribute to metabolic diseases, and how to assess the composition and function of the gut microbiota. (
  • A recently developed screening method makes it possible to screen newborns for several metabolic diseases, such as MCAD deficiency. (
  • it's that they cannot accept that this could be the truth behind the nature of the disease, because it changes how you approach treatment. (
  • In the presence of an appropriate indication, the various surgical treatment options for obesity and/or metabolic disease should be discussed with the patient. (
  • Moreover, the expression bariatric surgery has been replaced by obesity surgery in order to make it clear that such procedures are a treatment for the disease called obesity. (
  • Our Department is a major centre for the treatment of kidney, liver and metabolic diseases. (
  • Treatment focuses on reducing the complications of the associated chronic liver disease. (
  • Vaccination strategies for chronic diseases in particular are an exciting area of research, with new treatment targets and strategies on the horizon. (
  • We provide solid scientific evidence for the early identification of individuals at increased risk of metabolic diseases and their cardiovascular complications, for the improved diagnostics, prevention and treatment of metabolic diseases and their cardiovascular complications, the utilization of precision medicine in healthcare, improving cost-effectiveness of healthcare and limiting the increasing healthcare costs. (
  • Though diet-related diseases, or metabolic diseases, are the oldest diseases in humanity, an effective treatment for it eludes us, and it remains a leading cause of death. (
  • Finally, the talk will conclude with an example of a future research project that combines the fields of Protein and Metabolic Engineering, in an attempt to advance a new therapy for the treatment of Parkinson's disease. (
  • After observing weight gain in volunteers, US researchers found fat growth in the lower body such as the thighs was biologically different to fat growth in the abdomen, and this may explain why bigger thighs pose a lower risk of metabolic disease than a big belly. (
  • The researchers wrote in their background information that while we already know that different types of body fat and where it is situated affects the risk of metabolic disease in obesity , the underlying biology of fat gain is somewhat of a mystery. (
  • This site is used to accumulate student created resources relating to relationships between a number of chronic disease states and exercise/physical activity. (
  • In today's world, the incidence of cancer and chronic disease is at an all-time high and continues to rise. (
  • These diseases are caused by a problem with the genes that determine how specific enzymes are made. (
  • It is probably just one of many of different genes that each contribute to overall body shape and metabolic health. (
  • However, the increasing prevalence rates of diet-related diseases indicate that, in practice, people's diet does not follow the recommendations. (
  • Our group constructed a cohort in Chung-ju city, a rural area in Korea, to observe the prevalence of metabolic diseases and its risk factors since 2003. (
  • The three most common metabolic liver diseases are: hereditary hemochromatosis, Alpha-I antitrypsin deficiency (AATD), and Wilson Disease. (
  • Guideline] O'Shea RS, Dasarathy S, McCullough AJ, for the Practice Guideline Committee of the American Association for the Study of Liver Diseases. (
  • Perfused organ models coupled with Metabolic Flux Analysis have been used to quantitatively characterize these systemic responses, as well as the effects of interventions aimed at diminishing these responses, in both the liver and the skeletal muscle. (
  • Fatty liver disease is contributing to an increase in liver cancer and basic scientists at The University of Texas Health Science at Houston have new insight as to why. (
  • Following 20 weeks of aerobic exercise five days a week for 30 minutes, AMPK/mTORC1 is favorably changed shifting energy balance towards one where fatty liver disease can be improved. (
  • Hedgehog pathway activation parallels histologic severity of injury and fibrosis in human nonalcoholic fatty liver disease. (
  • Significant non-alcoholic fatty liver disease is found in non-diabetic, pre-obese Chinese in Singapore. (
  • De novo nonalcoholic fatty liver disease after liver transplantation. (
  • The natural history of nonalcoholic fatty liver disease: a population-based cohort study. (
  • Metabolic diseases are often hereditary, meaning they are passed to you from a family member. (
  • This is the only comprehensive authoritative review of the neuropathology of metabolic and neurodegenerative diseases. (