Symptoms of NAUSEA and VOMITING in pregnant women that usually occur in the morning during the first 2 to 3 months of PREGNANCY. Severe persistent vomiting during pregnancy is called HYPEREMESIS GRAVIDARUM.
A quantitative method of combining the results of independent studies (usually drawn from the published literature) and synthesizing summaries and conclusions which may be used to evaluate therapeutic effectiveness, plan new studies, etc., with application chiefly in the areas of research and medicine.
Works about clinical trials that involve at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table.
The first enzyme in the METHIONINE biosynthetic pathway, this enzyme catalyzes the succinylation reaction of L-homoserine to O-succinyl-L-homoserine and COENZYME A using succinyl-CoA.
The methyl esters of methacrylic acid that polymerize easily and are used as tissue cements, dental materials, and absorbent for biological substances.
Acrylic acids or acrylates which are substituted in the C-2 position with a methyl group.
Inorganic or organic compounds that contain boron as an integral part of the molecule.
A group of 1,2-benzenediols that contain the general formula R-C6H5O2.
Catalyzes the oxidation of catechol to 2-hydroxymuconate semialdehyde in the carbazole and BENZOATE degradation via HYDROXYLATION pathways. It also catalyzes the conversion of 3-methylcatechol to cis, cis-2-hydroxy-6-oxohept-2,4-dienoate in the TOLUENE and XYLENE degradation pathway. This enzyme was formerly characterized as EC 1.13.1.2.
A purplish-red, light-sensitive pigment found in RETINAL ROD CELLS of most vertebrates. It is a complex consisting of a molecule of ROD OPSIN and a molecule of 11-cis retinal (RETINALDEHYDE). Rhodopsin exhibits peak absorption wavelength at about 500 nm.
A widely used industrial solvent.
Dental cements composed either of polymethyl methacrylate or dimethacrylate, produced by mixing an acrylic monomer liquid with acrylic polymers and mineral fillers. The cement is insoluble in water and is thus resistant to fluids in the mouth, but is also irritating to the dental pulp. It is used chiefly as a luting agent for fabricated and temporary restorations. (Jablonski's Dictionary of Dentistry, 1992, p159)
A family of isomeric, colorless aromatic hydrocarbon liquids, that contain the general formula C6H4(CH3)2. They are produced by the destructive distillation of coal or by the catalytic reforming of petroleum naphthenic fractions. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Benzoic acid or benzoic acid esters substituted with one or more chlorine atoms.
Conferences, conventions or formal meetings usually attended by delegates representing a special field of interest.
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).
Accounting procedures for determining credit status and methods of obtaining payment.
Extensive collections, reputedly complete, of facts and data garnered from material of a specialized subject area and made available for analysis and application. The collection can be automated by various contemporary methods for retrieval. The concept should be differentiated from DATABASES, BIBLIOGRAPHIC which is restricted to collections of bibliographic references.
Elements of limited time intervals, contributing to particular results or situations.
A theorem in probability theory named for Thomas Bayes (1702-1761). In epidemiology, it is used to obtain the probability of disease in a group of people with some characteristic on the basis of the overall rate of that disease and of the likelihood of that characteristic in healthy and diseased individuals. The most familiar application is in clinical decision analysis where it is used for estimating the probability of a particular diagnosis given the appearance of some symptoms or test result.
Walking aids generally having two handgrips and four legs.
Disciplines concerned with the interrelationships of individuals in a social environment including social organizations and institutions. Includes Sociology and Anthropology.
A contagious disease caused by canine adenovirus (ADENOVIRUSES, CANINE) infecting the LIVER, the EYE, the KIDNEY, and other organs in dogs, other canids, and bears. Symptoms include FEVER; EDEMA; VOMITING; and DIARRHEA.
Diseases of the domestic dog (Canis familiaris). This term does not include diseases of wild dogs, WOLVES; FOXES; and other Canidae for which the heading CARNIVORA is used.
Sequential operating programs and data which instruct the functioning of a digital computer.
A single lung lesion that is characterized by a small round mass of tissue, usually less than 1 cm in diameter, and can be detected by chest radiography. A solitary pulmonary nodule can be associated with neoplasm, tuberculosis, cyst, or other anomalies in the lung, the CHEST WALL, or the PLEURA.
Removal and examination of tissue obtained through a transdermal needle inserted into the specific region, organ, or tissue being analyzed.
Tumors or cancer of the LUNG.
Diagnostic and therapeutic procedures that are invasive or surgical in nature, and require the expertise of a specially trained radiologist. In general, they are more invasive than diagnostic imaging but less invasive than major surgery. They often involve catheterization, fluoroscopy, or computed tomography. Some examples include percutaneous transhepatic cholangiography, percutaneous transthoracic biopsy, balloon angioplasty, and arterial embolization.
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
A country spanning from central Asia to the Pacific Ocean.
The upper part of the trunk between the NECK and the ABDOMEN. It contains the chief organs of the circulatory and respiratory systems. (From Stedman, 25th ed)
Published materials which provide an examination of recent or current literature. Review articles can cover a wide range of subject matter at various levels of completeness and comprehensiveness based on analyses of literature that may include research findings. The review may reflect the state of the art. It also includes reviews as a literary form.
Conduct and synthesis of systematic research comparing interventions and strategies to prevent, diagnose, treat, and monitor health conditions. The purpose of this research is to inform patients, providers, and decision-makers, responding to their expressed needs, about which interventions are most effective for which patients under specific circumstances. (hhs.gov/recovery/programs/cer/draftdefinition.html accessed 6/12/2009)
A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
The ceasing of existence of a species or taxonomic groups of organisms.
The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).

Statistical inference by confidence intervals: issues of interpretation and utilization. (1/1807)

This article examines the role of the confidence interval (CI) in statistical inference and its advantages over conventional hypothesis testing, particularly when data are applied in the context of clinical practice. A CI provides a range of population values with which a sample statistic is consistent at a given level of confidence (usually 95%). Conventional hypothesis testing serves to either reject or retain a null hypothesis. A CI, while also functioning as a hypothesis test, provides additional information on the variability of an observed sample statistic (ie, its precision) and on its probable relationship to the value of this statistic in the population from which the sample was drawn (ie, its accuracy). Thus, the CI focuses attention on the magnitude and the probability of a treatment or other effect. It thereby assists in determining the clinical usefulness and importance of, as well as the statistical significance of, findings. The CI is appropriate for both parametric and nonparametric analyses and for both individual studies and aggregated data in meta-analyses. It is recommended that, when inferential statistical analysis is performed, CIs should accompany point estimates and conventional hypothesis tests wherever possible.  (+info)

Variability in meta-analytic results concerning the value of cholesterol reduction in coronary heart disease: a meta-meta-analysis. (2/1807)

Despite official support for the efficacy of cholesterol reduction, considerable controversy exists, and meta-analyses of this topic have produced conflicting results. The authors assessed the variability of meta-analyses, evaluating the cardiovascular value of cholesterol reduction while attempting to explain the variability. Metaanalyses were identified by electronic search and citation tracking. Included were those conducted prior to 1995 that dealt with cholesterol reduction and total mortality, cardiovascular mortality, or nonfatal cardiovascular disease. In addition to extracting odds ratios for total mortality, cardiovascular mortality, and nonfatal cardiovascular disease, the authors encoded methodological variables, publication variables, and data concerning investigators' backgrounds. Twenty-three meta-analyses were reviewed, and 15 concluded that cholesterol reduction was beneficial. Summary odds ratios for total mortality were heterogeneous, generally failing to support the value of cholesterol reduction. Odds ratios depended on inclusion criteria and investigator variables. Odds ratios for cardiovascular mortality and for nonfatal cardiovascular disease were more homogeneous and supported the value of cholesterol reduction. Methodologically better meta-analyses tended to report more beneficial odds ratios. Although "supportiveness" of the value of cholesterol reduction was associated with inclusion/exclusion criteria and publication variables, the primary outcome variable related to supportiveness was the statistical significance of the odds ratios for cardiovascular mortality.  (+info)

Traditional reviews, meta-analyses and pooled analyses in epidemiology. (3/1807)

BACKGROUND: The use of review articles and meta-analysis has become an important part of epidemiological research, mainly for reconciling previously conducted studies that have inconsistent results. Numerous methodologic issues particularly with respect to biases and the use of meta-analysis are still controversial. METHODS: Four methods summarizing data from epidemiological studies are described. The rationale for meta-analysis and the statistical methods used are outlined. The strengths and limitations of these methods are compared particularly with respect to their ability to investigate heterogeneity between studies and to provide quantitative risk estimation. RESULTS: Meta-analyses from published data are in general insufficient to calculate a pooled estimate since published estimates are based on heterogeneous populations, different study designs and mainly different statistical models. More reliable results can be expected if individual data are available for a pooled analysis, although some heterogeneity still remains. Large prospective planned meta-analysis of multicentre studies would be preferable to investigate small risk factors, however this type of meta-analysis is expensive and time-consuming. CONCLUSION: For a full assessment of risk factors with a high prevalence in the general population, pooling of data will become increasingly important. Future research needs to focus on the deficiencies of review methods, in particular, the errors and biases that can be produced when studies are combined that have used different designs, methods and analytic models.  (+info)

Placenta previa: preponderance of male sex at birth. (4/1807)

To determine the relation between placenta previa and male sex at birth, the authors conducted two types of analysis: 1) a historical cohort analysis of singleton live births in New Jersey hospitals during 1989-1992 (N = 447,963); and 2) a meta-analysis of previously published studies on the subject. For the cohort analysis, subject mother-infant dyads were identified from linked birth certificate and maternal and infant hospital claims data. The infant's sex for mothers with an International Classification of Diseases, Ninth Revision, Clinical Modification, code of 641.0-641.1 for placenta previa (n = 2,685) was compared with infant's sex for mothers without placenta previa (n = 445,270). For the meta-analysis, seven published articles were located and summary effects were calculated using both fixed-effect and random-effects models. In the present cohort study, the male:female ratio at birth was significantly higher in women with placenta previa (1.19) than in those without placenta previa (1.05) (p<0.001). The association of placenta previa with male sex persisted when the analysis was either stratified or adjusted for the effects of maternal age, maternal parity, maternal smoking during the index pregnancy, race/ethnicity, the infant's gestational age, and the infant's birth weight. The meta-analytic results from the fixed-effect and random-effects models showed a 14% excess of placenta previa when women were carrying a viable male fetus as compared with a viable female fetus during pregnancy. The results were the same regardless of whether the present cohort study was included in the meta-analysis. In conclusion, the evidence obtained from these analyses strongly argues for an association between placenta previa and male sex at birth. The mechanism for this association remains to be determined.  (+info)

Glucocorticosteroids in the management of rheumatoid arthritis. (5/1807)

Glucocorticosteroids are used frequently in the management of patients with rheumatoid arthritis. Data supporting their efficacy and safety are still meagre. Glucocorticosteroids may be used systemically with different routes of administration (oral, i.m. and i.v.), in different doses and for different periods of time. The effectiveness of glucocorticosteroids in reducing inflammation in the short term has been shown for oral treatment in a dose of 7.5 mg prednisolone daily or more, for i.m. pulses (120 mg methylprednisolone every 4 weeks) and for i.v. methylprednisolone pulses. For longer periods of treatment, the evidence suggesting effectiveness of low-dose oral glucocorticosteroids is more limited. Some data suggest that different regimens of glucocorticosteroids may retard the development of erosions in patients with rheumatoid arthritis. The toxicity of short-term treatment is relatively low. For long-term treatment, the development of osteoporosis is a serious problem. Concomitant therapy with either calcitriol or bisphosphonates may reduce this risk.  (+info)

Evidence-based nephrology. (6/1807)

Systematic reviews and meta-analyses are the best approaches available for summarizing the available evidence concerning the efficacy of therapies. Although the renal field has been slow to use these techniques, they are being used increasingly. In March 1997, the Cochrane Renal Group was formed, and this group aims to produce and maintain up to date systematic reviews of the evidence on the effectiveness of therapies used to treat patients with renal diseases. This group is part of the Cochrane Collaboration which is an international structure grouping collaborators together, with the aim of preparing, maintaining and disseminating systematic reviews of the effects of health care in all areas of medicine.  (+info)

Evaluation of old and new tests of heterogeneity in epidemiologic meta-analysis. (7/1807)

The identification of heterogeneity in effects between studies is a key issue in meta-analyses of observational studies, since it is critical for determining whether it is appropriate to pool the individual results into one summary measure. The result of a hypothesis test is often used as the decision criterion. In this paper, the authors use a large simulation study patterned from the key features of five published epidemiologic meta-analyses to investigate the type I error and statistical power of five previously proposed asymptotic homogeneity tests, a parametric bootstrap version of each of the tests, and tau2-bootstrap, a test proposed by the authors. The results show that the asymptotic DerSimonian and Laird Q statistic and the bootstrap versions of the other tests give the correct type I error under the null hypothesis but that all of the tests considered have low statistical power, especially when the number of studies included in the meta-analysis is small (<20). From the point of view of validity, power, and computational ease, the Q statistic is clearly the best choice. The authors found that the performance of all of the tests considered did not depend appreciably upon the value of the pooled odds ratio, both for size and for power. Because tests for heterogeneity will often be underpowered, random effects models can be used routinely, and heterogeneity can be quantified by means of R(I), the proportion of the total variance of the pooled effect measure due to between-study variance, and CV(B), the between-study coefficient of variation.  (+info)

The role of vitamin D in corticosteroid-induced osteoporosis: a meta-analytic approach. (8/1807)

OBJECTIVE: To determine if vitamin D is more effective than no therapy or calcium alone in the management of corticosteroid-induced osteoporosis, and to determine how vitamin D compares with other osteoporosis therapies, e.g., bisphosphonates, calcitonin, or fluoride, for this condition. METHODS: We evaluated all formulations of vitamin D, including its active metabolites and analogs. A systematic search for published and unpublished studies was conducted using MEDLINE (1966-December 1997), bibliographic references, abstracts from proceedings of recent national meetings, and contact with pharmaceutical companies and content experts. We included all randomized controlled trials lasting at least 6 months (and reporting extractable results), of patients receiving oral corticosteroids, that compared vitamin D with either 1) no therapy or calcium alone, or 2) bisphosphonates, calcitonin, or fluoride. The primary outcome measure of interest was change in lumbar spine bone mineral density. RESULTS: We found a moderate beneficial effect of vitamin D plus calcium versus no therapy or calcium alone (9 trials) (effect size 0.60; 95% confidence interval [95% CI] 0.34, 0.85; P < 0.0001). In comparisons of vitamin D with other osteoporosis therapies, bisphosphonates were more effective than vitamin D (6 trials) (effect size 0.57; 95% CI 0.09, 1.05). Calcitonin was similar in efficacy to vitamin D (4 trials) (effect size 0.03; 95% CI -0.39, 0.45). Fluoride was more effective than vitamin D, but there were only 2 trials. CONCLUSION: Vitamin D plus calcium is superior to no therapy or calcium alone in the management of corticosteroid-induced osteoporosis. Vitamin D is less effective than some osteoporosis therapies. Therefore, treatment with vitamin D plus calcium, as a minimum, should be recommended to patients receiving long-term corticosteroids.  (+info)

TY - JOUR. T1 - Is aspirin effective in women undergoing in vitro fertilization (IVF)? Results from an individual patient data meta-analysis (IPD MA). AU - Groeneveld, E.. AU - Broeze, K. A.. AU - Lambers, M. J.. AU - Haapsamo, M.. AU - Dirckx, K.. AU - Schoot, B. C.. AU - Salle, B.. AU - Duvan, C. I.. AU - Schats, R.. AU - Mol, B. W.. AU - Hompes, P. G.A.. PY - 2011/7/1. Y1 - 2011/7/1. N2 - Background: Aspirin is believed to improve the outcome of IVF, but previous conventional meta-analyses on the subject are conflicting. Therefore, we performed a meta-analysis with individual patient data (IPD MA) of randomized clinical trials (RCTs) on the subject. Methods: A systematic literature search was conducted to identify RCTs assessing the effectiveness of aspirin in IVF. Authors were asked to share their original data. In a one step meta-analytic approach, the treatment effect of aspirin was estimated with odds ratios (ORs) and 95% confidence intervals (CIs) using logistic regression, based on the ...
BACKGROUND: Individual participant data (IPD) meta-analyses that obtain raw data from studies rather than summary data typically adopt a two-stage approach to analysis whereby IPD within trials generate summary measures, which are combined using standard meta-analytical methods. Recently, a range of one-stage approaches which combine all individual participant data in a single meta-analysis have been suggested as providing a more powerful and flexible approach. However, they are more complex to implement and require statistical support. This study uses a dataset to compare two-stage and one-stage models of varying complexity, to ascertain whether results obtained from the approaches differ in a clinically meaningful way. METHODS AND FINDINGS: We included data from 24 randomised controlled trials, evaluating antiplatelet agents, for the prevention of pre-eclampsia in pregnancy. We performed two-stage and one-stage IPD meta-analyses to estimate overall treatment effect and to explore potential
Medical education Comparing medical knowledge of osteopathic medical trainees in DO and MD programs: A random effect meta-analysis LINJUN SHEN, PhD; THOMAS CAVALIER!, DO; MICHAEL CLEARFIELD, DO; JOSEPH SMOLEY, PhD The authors used random effect meta-analysis to synthesize eight mean score differences of the Part BI/Level 3 examinations of the National Board of Osteo-pathic Medical Examiners (NBOME) between osteopathic medical trainees in DO residency programs and osteopathic medical trainees in MD programs. The anal-ysis involved 6001 trainees and all Part III or Level 3 examinations since 1992. The average mean score difference was not significantly different from zero; however, the estimates of true effect sizes of each examination varied substantially. The findings indicate that, overall, medical knowledge of osteopathic trainees in MD and DO residency programs is compatible at the time they took the exam-inations. However, a large variation of effect size suggests the need for further ...
TY - JOUR. T1 - The Meta VCI Map consortium for meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping. T2 - Design and multicenter pilot study. AU - Meta VCI Map consortium. AU - Calgary Normative Study group. AU - Framingham Heart Study group. AU - The Dutch Parelsnoer Institute - Neurodegenerative diseases group. AU - TABASCO group. AU - Weaver, Nick A.. AU - Zhao, Lei. AU - Biesbroek, J. Matthijs. AU - Kuijf, Hugo J.. AU - Aben, Hugo P.. AU - Bae, Hee Joon. AU - Caballero, Miguel Á.A.. AU - Chappell, Francesca M.. AU - Chen, Christopher P.L.H.. AU - Dichgans, Martin. AU - Duering, Marco. AU - Georgakis, Marios K.. AU - van der Giessen, Ruben S.. AU - Gyanwali, Bibek. AU - Hamilton, Olivia K.L.. AU - Hilal, Saima. AU - vom Hofe, Elise M.. AU - de Kort, Paul L.M.. AU - Koudstaal, Peter J.. AU - Lam, Bonnie Y.K.. AU - Lim, Jae Sung. AU - Makin, Stephen D.J.. AU - Mok, Vincent C.T.. AU - Shi, Lin. AU - Valdés Hernández, Maria C.. AU - ...
TY - JOUR. T1 - Repeat prenatal corticosteroid prior to preterm birth. T2 - A systematic review and individual participant data meta-analysis for the PRECISE study group (prenatal repeat corticosteroid international IPD study group: Assessing the effects using the best level of evidence) - study protocol. AU - Crowther, Caroline A.. AU - Aghajafari, Fariba. AU - Askie, Lisa M.. AU - Asztalos, Elizabeth V.. AU - Brocklehurst, Peter. AU - Bubner, Tanya K.. AU - Doyle, Lex W.. AU - Dutta, Sourabh. AU - Garite, Thomas J.. AU - Guinn, Debra A.. AU - Hallman, Mikko. AU - Hannah, Mary E.. AU - Hardy, Pollyanna. AU - Maurel, Kimberly. AU - Mazumder, Premasish. AU - McEvoy, Cynthia (Cindy). AU - Middleton, Philippa F.. AU - Murphy, Kellie E.. AU - Peltoniemi, Outi M.. AU - Peters, Dawn. AU - Sullivan, Lisa. AU - Thom, Elizabeth A.. AU - Voysey, Merryn. AU - Wapner, Ronald J.. AU - Yelland, Lisa. AU - Zhang, Sasha. PY - 2012/2/12. Y1 - 2012/2/12. N2 - Background: The aim of this individual participant ...
Fingerprint Dive into the research topics of Prognostic factors for adolescent knee pain: an individual participant data meta-analysis of 1281 patients. Together they form a unique fingerprint. ...
PubMed journal article Use of statins and fracture: results of 4 prospective studies and cumulative meta-analysis of observational studies and controlled trial were found in PRIME PubMed. Download Prime PubMed App to iPhone or iPad.
The objective of the present study was to review previous investigations on the association of haplotypes in the G-protein β3 subunit (GNB3) gene with representative cardiovascular risk factors/phenotypes: hypertension, overweight, and variation in the systolic and diastolic blood pressures (SBP and DBP, respectively) and as well as body mass index (BMI). A comprehensive literature search was undertaken in Pubmed, Web of Science, EMBASE, Biological Abstracts, LILACS and Google Scholar to identify potentially relevant articles published up to April 2011. Six genetic association studies encompassing 16,068 participants were identified. Individual participant data were obtained for all studies. The three most investigated GNB3 polymorphisms (G-350A, C825T and C1429T) were considered. Expectation-maximization and generalized linear models were employed to estimate haplotypic effects from data with uncertain phase while adjusting for covariates. Study-specific results were combined through a ...
BACKGROUND: Calls have been made for increased access to individual participant data (IPD) from clinical trials, to ensure that complete evidence is available. However, despite the obvious benefits, progress towards this is frustratingly slow. In the meantime, many systematic reviews have already collected IPD from clinical trials. We propose that a central repository for these IPD should be established to ensure that these datasets are safeguarded and made available for use by others, building on the strengths and advantages of the collaborative groups that have been brought together in developing the datasets. OBJECTIVE: Evaluate the level of support, and identify major issues, for establishing a central repository of IPD. DESIGN: On-line survey with email reminders. PARTICIPANTS: 71 reviewers affiliated with the Cochrane Collaborations IPD Meta-analysis Methods Group were invited to participate. RESULTS: 30 (42%) invitees responded: 28 (93%) had been involved in an IPD review and 24 (80%) had been
Meta-analysis has a long history within the medical sciences and epidemiology [1,2,3]. The main goal of a meta-analysis is to improve the precision of a specific effect size of a treatment or an exposure on a clinical or disease outcome by pooling or combining multiple studies. It is frequently conducted within a systematic review of the scientific literature to guarantee that studies with appropriate information are not ignored or overlooked and to make sure that the pooled estimate represents an unbiased and precise estimate of the true effect size. Moreover, the pooled effect estimate is evaluated in the context of study heterogeneity. In case substantial heterogeneity in the effect sizes across studies is present, the pooled estimate is considered less reliable or even questionable. Thus not only the pooled estimate must be unbiased, also the estimate of the measure of heterogeneity should be correct. Within the area of medical statistics, meta-analysis has evolved into an important and rich ...
A multivariate meta-analysis of two or more correlated outcomes is expected to improve precision compared with a series of independent, univariate meta-analyses especially when there are studies reporting some but not all outcomes. Multivariate meta-analysis requires estimates of the within-study correlations, which are seldom available. Existing methods for analysing multiple outcomes simultaneously are limited to pairwise treatment comparisons. We propose a model for a joint, simultaneous synthesis of multiple dichotomous outcomes in a network of interventions and introduce a simple way to elicit expert opinion for the within-study correlations by utilizing a set of conditional probability parameters. We implement our multiple-outcomes network meta-analysis model within a Bayesian framework, which allows incorporation of expert information. As an example, we analyse two correlated dichotomous outcomes, response to the treatment and dropout rate, in a network of pharmacological interventions for acute
A multivariate meta-analysis of two or more correlated outcomes is expected to improve precision compared with a series of independent, univariate meta-analyses especially when there are studies reporting some but not all outcomes. Multivariate meta-analysis requires estimates of the within-study correlations, which are seldom available. Existing methods for analysing multiple outcomes simultaneously are limited to pairwise treatment comparisons. We propose a model for a joint, simultaneous synthesis of multiple dichotomous outcomes in a network of interventions and introduce a simple way to elicit expert opinion for the within-study correlations by utilizing a set of conditional probability parameters. We implement our multiple-outcomes network meta-analysis model within a Bayesian framework, which allows incorporation of expert information. As an example, we analyse two correlated dichotomous outcomes, response to the treatment and dropout rate, in a network of pharmacological interventions for acute
Network meta-analyses are increasingly used to determine the best available healthcare interventions among all existing treatments for one specific disease. We showed that the conduct, reporting and interpretation of network meta-analyses was questionable. Particularly, the search strategy, assessment of risk of bias and publication bias were inappropriate in most publications. Furthermore, we showed that treatment rankings usually reported with no credibility interval have a substantial degree of imprecision, with a 50% or greater probability that the best-ranked treatment was actually not the best in 28% of networks. We also investigated whether conventional meta-analyses meet clinicians and patients needs. Our results revealed a substantial waste of research, with more than 40% of treatments, treatment comparisons, and trials not covered by existing systematic reviews. We developed a new paradigm, the live cumulative network meta-analysis, a single network meta-analysis covering all ...
An Individual Patient Data (IPD) meta-analysis is often considered the gold-standard for synthesising survival data from clinical trials. An IPD meta-analysis can be achieved by either a two-stage or a one-stage approach, depending on whether the trials are analysed separately or simultaneously. A range of one-stage hierarchical Cox models have been previously proposed, but these are known to be computationally intensive and are not currently available in all standard statistical software. We describe an alternative approach using Poisson based Generalised Linear Models (GLMs). We illustrate, through application and simulation, the Poisson approach both classically and in a Bayesian framework, in two-stage and one-stage approaches. We outline the benefits of our one-stage approach through extension to modelling treatment-covariate interactions and non-proportional hazards. Ten trials of hypertension treatment, with all-cause death the outcome of interest, are used to apply and assess the approach. We
An Individual Patient Data (IPD) meta-analysis is often considered the gold-standard for synthesising survival data from clinical trials. An IPD meta-analysis can be achieved by either a two-stage or a one-stage approach, depending on whether the trials are analysed separately or simultaneously. A range of one-stage hierarchical Cox models have been previously proposed, but these are known to be computationally intensive and are not currently available in all standard statistical software. We describe an alternative approach using Poisson based Generalised Linear Models (GLMs). We illustrate, through application and simulation, the Poisson approach both classically and in a Bayesian framework, in two-stage and one-stage approaches. We outline the benefits of our one-stage approach through extension to modelling treatment-covariate interactions and non-proportional hazards. Ten trials of hypertension treatment, with all-cause death the outcome of interest, are used to apply and assess the approach. We
We consider random effects meta-analysis where the outcome variable is the occurrence of some event of interest. The data structures handled are where one has one or more groups in each study, and in each group either the number of subjects with and without the event, or the number of events and the …
An application of multivariate meta-analysis for pooling estimates of non-linear associations from multiple studies. The code included is applicable beyond the specific setting of time series analysis of temperature-health relationships. The example illustrate the analysis in the article: Gasparrini A, Armstrong B, Kenward MG. Multivariate meta-analysis for non-linear and other multi-parameter associations. Statistics in Medicine. 2012;31(29):3821-39. The original example included in the article was based on data from the National Mortality, Morbidity, and Air Pollution Study (NMMAPS), which at the time of the publication was available through the R package NMMAPSlite. Unfortunately, the data are not available any more and the package NMMAPSlite has been archived. In order to provide a working example, the analysis has been replaced with a similar analysis on a publicly available dataset. The material covers: [1] regEngWales.csv stores the dataset used to perform an illustrative example, ...
TY - JOUR. T1 - Selenium and Prostate Cancer. T2 - Analysis of Individual Participant Data From Fifteen Prospective Studies. AU - Allen, Naomi E.. AU - Travis, Ruth C.. AU - Appleby, Paul N.. AU - Albanes, Demetrius. AU - Barnett, Matt J. AU - Black, Amanda. AU - Bueno-de-Mesquita, H Bas. AU - Deschasaux, Mélanie. AU - Galan, Pilar. AU - Goodman, Gary E.. AU - Goodman, Phyllis J.. AU - Gunter, Marc J.. AU - Heliövaara, Markku. AU - Helzlsouer, Kathy J. AU - Henderson, Brian E.. AU - Hercberg, Serge. AU - Knekt, Paul. AU - Kolonel, Laurence N.. AU - Lasheras, Christina. AU - Linseisen, Jakob. AU - Metter, E. Jeffrey. AU - Neuhouser, Marian L.. AU - Olsen, Anja. AU - Pala, Maria Valeria. AU - Platz, Elizabeth A. AU - Rissanen, Harri. AU - Reid, Mary E. AU - Schenk, Jeannette M. AU - Stampfer, Meir J. AU - Stattin, Pär. AU - Tangen, Catherine M. AU - Touvier, Mathilde. AU - Trichopoulou, Antonia. AU - van den Brandt, Piet A. AU - Key, Timothy J.. AU - Endogenous Hormones, Nutritional Biomarkers ...
Confidence intervals for the between-study variance in random-effects meta-analysis using generalised heterogeneity statistics: should we use unequal tails. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
We read with deep interest the article by Wang et al1 aimed to compare the efficacy of 20 non-steroidal anti-inflammatory drugs (NSAIDs) in the short-term treatment of ankylosing spondylitis (AS). This Bayesian network meta-analysis indicated that etoricoxib was more effective in reducing pain in AS than some other NSAIDs. The result was very useful in the decision-making process, especially for pain relief in treating patients with AS. However, there are some worthwhile issues that need to be explored.. First, it is commonly agreed that meta-analysis, including network meta-analysis, should assess heterogeneity, which may be defined as the presence of variation in true effect sizes underlying the different studies. Unfortunately, however, heterogeneity was not assessed in this network meta-analysis. Between-study heterogeneity indicates the presence of effect modifiers, and variability in relative treatment effects has a bad impact on the external validity of trial evidence, and limits the ...
Background: Frequently, interventions for a given health problem have never been compared in head-to-head randomized controlled trials. In this context, adjusted indirect comparisons based on network meta-analyses (NMAs) could answer the question posed by most healthcare professionals: what is the best intervention among the existing interventions for a specific condition? Objectives: To evaluate the trend in NMAs publication topic in medical electronic databases and in the top five impact factor journals in the Medicine, General and Internal category. Methods: A search strategy was performed in Medline (PubMed), EMBASE, and CENTRAL, since inception (Figure 1). We analysed the general yearly trend all together and separately by database and by journal. Results: During the analysed period, the reporting of studies mentioning NMA has increased since the beginning of the XXI century and markedly since 2009. EMBASE was the database with the highest cumulative number of references bout NMA and the ...
The continuous development and refinement of techniques is a key attribute of the discipline of surgery. Robust evidence derived from randomised clinical trials and subsequent synthesis using meta-analysis methods is therefore an indispensable tool in modern evidence-based surgical practice. This thesis aimed to address two challenges to the development of this evidence, namely the synthesis of trial data where multiple treatment comparisons exist, and the influence of sources of bias on the results of surgical randomised trials. Research synthesis typically employs pairwise meta-analysis methods to summarise trial data. However, there are more than two treatment options available for most conditions, meaning that data pertaining to all treatments cannot be incorporated using pairwise methodology. Network meta-analysis allows for the simultaneous comparison of multiple treatments and enables their ranking in terms of benefit and harm. This thesis used two different examples to explore this ...
BACKGROUND: The last 30 years have seen an exponential increase in metaanalyses. By combining multiple studies, metaanalysis can provide an overview of the totality of evidence on a particular question and the statistical power needed to reduce random error and produce precise estimates of even modest effect sizes. This capability is of particular value when many small studies address similar questions [such as in the investigation of novel cardiovascular disease (CVD) biomarkers]. To provide reliable evidence, however, metaanalyses must be undertaken robustly. CONTENT: In this review, we describe the major issues to consider when designing and conducting metaanalyses, including the design of constituent studies, selection criteria, assessment of exposures and disease outcomes, and control of bias and confounding. Some of the potential challenges and pitfalls associated with metaanalysis are examined, and their consequences are considered. We use 2 examples of novel biomarkers for CVD-homocysteine and
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Meta-analysis is the use of statistical methods to combine evidence across studies for the purposes of drawing general conclusions. The results of each study are summarized by a quantitative index called an effect size, and then the effect sizes from each study are combined across studies to obtain an overall summary effect. Meta-analysis differs from secondary analysis because the latter involves analysis of the raw data from each study, but meta-analysis typically uses only summaries of the raw data from each study (the effect sizes), not the raw data itself. Meta-analyses may have any of several primary objectives. In many cases, meta-analyses are carried out to obtain a summary of average effects. In other cases, they may be carried out to study differential effects of a treatment on different subject populations, different treatment contexts, different variations of a treatment, or different outcome measures. It is also common for meta-analysts to use their results to identify areas of ...
What is the little thing you can do to increase reproducibility, replicability and trust in science? How can reporting quality interfere with reproducibility issues and overall trust in science results? With that question in mind, we participated in the Reproducibility, Replicability and Trust in Science conference organised by the Wellcome Genome Campus from 9 to 11.... ...
The purpose of the Bulletin of Economics and Meta-Analysis (BEMA) is to provide a forum for recent meta-analyses in economics, to publish fresh research quickly, and thereby to improve the quality of meta-analytic research before it is submitted to traditional scholarly journals. We seek to publish, electronically, short notes and longer abstracts that briefly sketch recent research about meta-analysis or that employs meta-analysis. It is assumed that all notes submitted will contain links to longer working papers. Authors wishing to have their notes considered for publication in BEMA should submit them for review to: [email protected] ...
Fast and easy meta-analysis software. Research synthesis, systematic review for finding effect size, creating forest plots, and much more. Free trial.
Background and aims: Our study aims to evaluate the efficacy and safety of long-term treatment of statins for coronary heart disease (CHD). Methods: Efficacy outcomes included changes in blood lipids, risk of CHD mortality and all-cause mortality. Safety outcomes were evaluated by the risk of adverse events (AE). Bayesian network meta-analysis was used to compare the direct and indirect effects between different statins. Results: The systematic review showed that levels of blood lipids decreased during statin treatment. High dose of atorvastatin was the most obvious treatment for the reduction of blood lipids. Network meta-analysis showed that statins were significantly more effective than the control in reducing the risk of CHD mortality (Odds Ratio (OR) 0.69, 95% CI 0.61-0.77) and all-cause mortality (OR 0.84, 95% CI 0.80-0.87). In terms of reducing the risk of CHD morality, fluvastatin (77.3%), atorvastatin (72.3%) and lovastatin (68.4%) had higher cumulative probability than other statins, ...
Compute variance-covariance matrix for multivariate meta-analysis. Effect sizes include correlation (r), mean difference (MD), standardized mean difference (SMD), log odds ratio (logOR), log risk ratio (logRR), and risk difference (RD).. ...
Evidence-based health-care decision making requires comparisons of all relevant competing interventions. In the absence of randomized, controlled trials involving a direct comparison of all treatments of interest, indirect treatment comparisons and network meta-analysis provide useful evidence for j …
BACKGROUND: Understanding of the genetic basis of type 2 diabetes (T2D) has progressed rapidly, but the interactions between common genetic variants and lifestyle risk factors have not been systematically investigated in studies with adequate statistical power. Therefore, we aimed to quantify the combined effects of genetic and lifestyle factors on risk of T2D in order to inform strategies for prevention. METHODS AND FINDINGS: The InterAct study includes 12,403 incident T2D cases and a representative sub-cohort of 16,154 individuals from a cohort of 340,234 European participants with 3.99 million person-years of follow-up. We studied the combined effects of an additive genetic T2D risk score and modifiable and non-modifiable risk factors using Prentice-weighted Cox regression and random effects meta-analysis methods. The effect of the genetic score was significantly greater in younger individuals (p for interaction = 1.20×10-4). Relative genetic risk (per standard deviation [4.4 risk alleles]) was
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Here are three studies (for all abstracts & links see below) highlighting the increasingly encouraging results being reported for internet-delivered psychological interventions. Vant Hof, Cuijpers et al report on ... a systematic review of meta-analyses on the efficacy of self-help interventions, including internet-guided therapy, for depression and anxiety disorders. They conclude that the 13 meta-analyses indicate self-help methods are effective in a range of different disorders, including depression and anxiety disorders. Most meta-analyses found relatively large effect sizes for self-help treatments, independent of the type of self-help, and comparable to effect sizes for face-to-face treatments (see below for abstracts and links to the six research papers mentioned). Riper, Kramer et al describe how an experimental internet-delivered self-help alcohol reduction intervention transferred well to being made more generally available. The authors conclude that .... ...
Here are three studies (for all abstracts & links see below) highlighting the increasingly encouraging results being reported for internet-delivered psychological interventions. Vant Hof, Cuijpers et al report on ... a systematic review of meta-analyses on the efficacy of self-help interventions, including internet-guided therapy, for depression and anxiety disorders. They conclude that the 13 meta-analyses indicate self-help methods are effective in a range of different disorders, including depression and anxiety disorders. Most meta-analyses found relatively large effect sizes for self-help treatments, independent of the type of self-help, and comparable to effect sizes for face-to-face treatments (see below for abstracts and links to the six research papers mentioned). Riper, Kramer et al describe how an experimental internet-delivered self-help alcohol reduction intervention transferred well to being made more generally available. The authors conclude that .... ...
The number of studies on the association between clock genes polymorphisms and cancer susceptibility has increased over the last years but the results are often conflicting and no comprehensive overview and quantitative summary of the evidence in this field is available. RESULTS: Literature search identified 27 eligible studies comprising 96756 subjects (cases: 38231) and investigating 687 polymorphisms involving 14 clock genes. Overall, 1025 primary and subgroup meta-analyses on 366 gene variants were performed. Study distribution by tumor was as follows: breast cancer (n=15), prostate cancer (n=3), pancreatic cancer (n=2), non-Hodgkins lymphoma (n=2), glioma (n=1), chronic lymphocytic leukemia (n=1), colorectal cancer (n=1), non-small cell lung cancer (n=1) and ovarian cancer (n=1).We identified 10 single nucleotide polymorphisms (SNPs) significantly associated with cancer risk: NPAS2 rs10165970 (mixed and breast cancer shiftworkers), rs895520 (mixed), rs17024869 (breast) and rs7581886 ...
TY - JOUR. T1 - Dealing with missing standard deviation and mean values in meta-analysis of continuous outcomes: a systematic review. AU - Weir, Christopher J. AU - Butcher, Isabella. AU - Assi, Valentina. AU - Lewis, Stephanie C. AU - Murray, Gordon. AU - Langhorne, Peter. AU - Brady, Marian. N1 - Acceptance in SAN OA article Funding: This project was funded by The Stroke Association, grant number 2012/05 with additional support from the Rosetrees Trust.. PY - 2018/3/7. Y1 - 2018/3/7. N2 - Abstract BackgroundRigorous, informative meta-analyses rely on availability of appropriate summary statistics or individual participant data. For continuous outcomes, especially those with naturally skewed distributions, summary information on the mean or variability often goes unreported. While full reporting of original trial data is the ideal, we sought to identify methods for handling unreported mean or variability summary statistics in meta-analysis.MethodsWe undertook two systematic literature reviews ...
A study appeared this week sure to drive members of the low-fat and vegan tribes sprinting for their Protexid.. Ron Krauss and his group published a paper in the Articles in Press section of the American Journal of Clinical Nutrition (AJCN) stating there is no evidence that saturated fat intake increases the risk for heart disease. The paper, titled Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease, is not a study per se, but is a meta-analysis, a compilation of numerous studies looking at the relationship between saturated fat intake and the risk for developing heart disease.. As Ive discussed before on these pages, meta-analyses are not my favorite types of studies. Ive attacked them when theyve been used to prove the low-fat diets are better, so I cant very well embrace meta-analyses when they present a conclusion I agree with. And I really cant embrace meta-analyses when they are compilations of observational studies, ...
In this article, we provide guidance on how to systematically review and quantitatively synthesize the predictive performance of a prediction model. Although we focused on systematic review and meta-analysis of a prognostic model, all guidance can similarly be applied to the meta-analysis of a diagnostic prediction model. We discussed how to define the systematic review question, identify the relevant prediction model studies from the literature, critically appraise the identified studies, extract relevant summary statistics, quantitatively summarise the extracted estimates, and investigate sources of between-study heterogeneity.. Meta-analysis of a prediction models predictive performance bears many similarities to other types of meta-analysis. However, in contrast to synthesis of randomised trials, heterogeneity is much more likely in meta-analysis of studies assessing the predictive performance of a prediction model, owing to the increased variation of eligible study designs, increased ...
There is an emerging body of literature relating to the effectiveness of frequent aerobic exercise as a prophylactic for age-associated dysfunction of large arteries, yet systematic evaluation and precise estimate of this effect is unknown. We conducted a systematic review and meta-analysis of controlled studies examining flow mediated dilatation (FMD) of athletic older persons and otherwise healthy sedentary counterparts to (i) compare FMD as a determinant of endothelial function between athletes and sedentary individuals and, (ii) summarize the effect of exercise training on FMD in studies of sedentary aging persons. Studies were identified from systematic search of major electronic databases from inception to January 2018. Study quality was assessed before conducting a random effects meta-analysis to calculate a pooled ES (mean difference) with 95% CIs. Thirteen studies [4 interventional (n = 125); 10 cross-sectional [including one study from the interventional analysis; (n = 485)] with age ...
Objective: Spontaneous or experimentally induced high blood pressure (BP) is associated with reduced pain perception, known as BP-related hypoalgesia. Despite its clinical implications, such as the interference with early detection of myocardial infarction in at risk groups, the size of the association between high BP and pain has not yet been quantified. Moreover, the distinct association between high BP and physiological or psychological components of pain has not yet been considered so far. The aim of this study was to overcome this gap by performing separate meta-analyses on nociceptive response versus quantifiable perceptual measures of pain in relation to high BP. Methods: PubMed and Web of Knowledge databases were searched for English language studies conducted in humans. Fifty-nine studies were eligible for the analyses. Pooled effect sizes (Hedges g) were compared. Random effect models were used. Results show that higher BP is significantly associated with lower nociceptive response ...
Findings Twenty NMAs were eligible for inclusion. The number of randomised controlled trials per NMA ranged from 11 to 234, and included between 801 to more than 26 000 participants. Overall, antidepressants were found to be efficacious and tolerable agents for several disorders based on rankings (45%) or statistical significance (55%). The majority of NMAs in this review adhered to guidelines by including a network diagram (70%), assessing consistency (75%), making use of a random effects model (75%), providing information on the model used to fit the data (75%) and adjusting for covariates (75%). ...
Results from the present study add to the growing body of studies showing that iSMIs can be an accessible and effective way of reducing work-related stress. In line with our expectations, we found that the guided iSMI effectively reduces symptoms of perceived stress in a sample of distressed managers. Analyses also indicate effects on other mental health and work-related outcomes. Long-term effects were seen on several of the mental health-related outcomes (perceived stress, insomnia and cognitive weariness). However, effects on the work-related outcomes were not sustained at the 6 months follow-up.. The effects found in the present study were larger compared with those found in our previous iSMIs trials (d≈0.60),23 25 however within CI of guided interventions (Cohens d=0.64, 95% CI 0.50 to 0.79) presented in a recently published meta-analyses on iSMI.24 Compared with regular face-to-face CBT-based SMIs, d=0.68 to 1.16,17 our effects are lower on stress-related measures (perceived stress, ...
It is considered that fruit and vegetable (F&V) protect against oesophagus and gastric cancer (GC). However, 2 recent meta-analyses suggest that the strength of association on GC seems to be weaker for vegetables than for fruit and weaker in cohort than in case-control studies. No evidence exists from cohort studies about adenocarcinoma of oesophagus (ACO). In 521,457 men and women participating in the EPIC cohort in 10 European countries, information of diet and lifestyle was collected at baseline. After an average of 6.5 years of follow-up, a total of 330 GC and 65 ACO, confirmed and classified by a panel of pathologists, was used for the analysis. We examined the relation between F&V intake and GC and ACO. A calibration study in a sub-sample was used to control diet measurement errors. In a sub-sample of cases and a random sample of controls, antibodies against Helicobacter pylori (Hp) were measured and interactions with F&V were examined in a nested case-control study. We observed no ...
Meta-analysis is a formal quantitative method for pooling scientific data reported from multiple studies, therefore allowing for an evaluation of the treatment or exposure effect on a specific health outcome. In a meta-analysis, researchers assess heterogeneity across studies, examine subgroups of studies to determine if selected subsets of the research data provide similar or different results, and calculate summary relative risk estimates. A meta-analysis provides a statistically precise summary risk estimate, as well as a better understanding of the consistency of reported findings (or lack of) in the research literature. A meta-analysis is distinct from a qualitative or narrative review in that a meta-analysis involves a systematic review of the literature, relevant data extraction, and quantitative analyses of data across multiple studies. A pooled analysis is similar to a traditional meta-analysis, except that participant-level data from multiple studies are combined and analyzed as a ...
Meta-analysis can be used to examine differences in treatment effects across trials; however, the fact that randomised trials are included in meta-analyses does not mean that comparisons between trials are also randomised comparisons. Meta-analytic subgroup analyses, like subgroup analyses within trials, are prone to bias and need to be interpreted with caution. A more reliable way of assessing differences in treatment effects is to relate outcome to some underlying patient characteristic on a continuous, or ordered, scale. The underlying level of risk is a key variable which is often related to a given treatment effect, with patients at higher risk receiving more benefit then low risk patients. Individual patient data, rather than published summary statistics, are often required for meaningful subgroup analyses. ...
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Caroline Crowther, Philippa Middleton, Merryn Voysey, Lisa Askie, Lelia Duley, et al.. Assessing the neuroprotective benefits for babies of antenatal magnesium sulphate: An individual participant data meta-analysis. PLoS Medicine, Public Library of Science, 2017, 14 (10), pp.e1002398. ⟨10.1371/journal.pmed.1002398⟩. ⟨hal-02452278⟩ ...
Pooling of data from 14,874 women in an individual participant data meta-analysis by Nicola Low and colleagues reveals that some intravaginal practices increase the risk of HIV acquisition.
Dietary Reference Values (DRVs) for vitamin D have a key role in the prevention of vitamin D deficiency. However, despite adopting similar risk assessment protocols, estimates from authoritative agencies over the last 6 years have been diverse. This may have arisen from diverse approaches to data analysis. Modelling strategies for pooling of individual subject data from cognate vitamin D randomized controlled trials (RCTs) are likely to provide the most appropriate DRV estimates. Thus, the objective of the present work was to undertake the first-ever individual participant data (IPD)-level meta-regression, which is increasingly recognized as best practice, from seven winter-based RCTs (with 882 participants ranging in age from 4 to 90 years) of the vitamin D intake-serum 25-hydroxyvitamin D (25(OH)D) dose-response. Our IPD-derived estimates of vitamin D intakes required to maintain 97.5% of 25(OH)D concentrations >25, 30, and 50 nmol/L across the population are 10, 13, and 26 µg/day, respectively.
TY - JOUR. T1 - A collaborative analysis of individual participant data from 19 prospective studies assesses circulating vitamin D and prostate cancer risk. AU - Travis, Ruth C. AU - Martin, Richard. AU - Donovan, Jenny. PY - 2018/11/13. Y1 - 2018/11/13. KW - prostate cancer. KW - vitamin D. KW - 25-hydroxyvitamin D. KW - 1,25-dihydroxyvitamin D. KW - pooled analysis. U2 - 10.1158/0008-5472.CAN-18-2318. DO - 10.1158/0008-5472.CAN-18-2318. M3 - Article (Academic Journal). C2 - 30425058. JO - Cancer Research. JF - Cancer Research. SN - 0008-5472. ER - ...
OBJECTIVES: Early saphenous vein graft (SVG) occlusion is typically attributed to technical factors. We aimed at exploring clinical, anatomical, and operative factors associated with the risk of early SVG occlusion (within 12 months postsurgery). METHODS: Published literature in MEDLINE was searched for studies reporting the incidence of early SVG occlusion. Individual patient data (IPD) on early SVG occlusion were used from the SAFINOUS-CABG Consortium. A derivation (n = 1492 patients) and validation (n = 372 patients) cohort were used for model training (with 10-fold cross-validation) and external validation respectively. RESULTS: In aggregate data meta-analysis (48 studies, 41,530 SVGs) the pooled estimate for early SVG occlusion was 11%. The developed IPD model for early SVG occlusion, which included clinical, anatomical, and operative characteristics (age, sex, dyslipidemia, diabetes mellitus, smoking, serum creatinine, endoscopic vein harvesting, use of complex grafts, grafted target vessel, and
article{2a540d9f-73ba-41d7-8442-fe16f20afb72, abstract = {,p,Emerging evidence suggests that the basis for variation in late-life mobility is attributable, in part, to genetic factors, which may become increasingly important with age. Our objective was to systematically assess the contribution of genetic variation to gait speed in older individuals. We conducted a meta-analysis of gait speed GWASs in 31,478 older adults from 17 cohorts of the CHARGE consortium, and validated our results in 2,588 older adults from 4 independent studies. We followed our initial discoveries with network and eQTL analysis of candidate signals in tissues. The meta-analysis resulted in a list of 536 suggestive genome wide significant SNPs in or near 69 genes. Further interrogation with Pathway Analysis placed gait speed as a polygenic complex trait in five major networks. Subsequent eQTL analysis revealed several SNPs significantly associated with the expression of PRSS16, WDSUB1 and PTPRT, which in addition to the ...
Downloadable! Despite the vast literature dealing with the impact of the subsidies on world cotton prices, there is no consensus regarding the quantification of these effects. The aim of this paper is to contribute to this literature through the implementation of a meta-regression analysis. This methodology allows us to: (i) identify the main sources of heterogeneity between the primary studies, (ii) give some tracks to improve the modeling, (iii) provide a reliable quantification of the removal of subsidies on world cotton prices. Relying on the estimation of various models to derive robust results, our findings show that a withdrawal of US subsidies would increase the world cotton price by around 10%.
© 2017 Tucker et al. Background: Self-monitoring of blood pressure (BP) appears to reduce BP in hypertension but important questions remain regarding effective implementation and which groups may benefit most. This individual patient data (IPD) meta-analysis was performed to better understand the effectiveness of BP self-monitoring to lower BP and control hypertension. Methods and findings: Medline, Embase, and the Cochrane Library were searched for randomised trials comparing self-monitoring to no self-monitoring in hypertensive patients (June 2016). Two reviewers independently assessed articles for eligibility and the authors of eligible trials were approached requesting IPD. Of 2,846 articles in the initial search, 36 were eligible. IPD were provided from 25 trials, including 1 unpublished study. Data for the primary outcomes-change in mean clinic or ambulatory BP and proportion controlled below target at 12 months-were available from 15/19 possible studies (7,138/8,292 [86%] of randomised
Granulocyte colony stimulating factor (G-CSF) may enhance recovery from stroke through neuroprotective mechanisms if administered early, or neurorepair if given later. Several small trials suggest administration is safe but effects on efficacy are unclear. We searched for randomised controlled trials (RCT) assessing G-CSF in patients with hyperacute, acute, subacute or chronic stroke, and asked Investigators to share individual patient data on baseline characteristics, stroke severity and type, end-of trial modified Rankin Scale (mRS), Barthel Index, haematological parameters, serious adverse events and death. Multiple variable analyses were adjusted for age, sex, baseline severity and time-to-treatment. Individual patient data were obtained for 6 of 10 RCTs comprising 196 stroke patients (116 G-CSF, 80 placebo), mean age 67.1 (SD 12.9), 92% ischaemic, median NIHSS 10 (IQR 5-15), randomised 11 days (interquartile range IQR 4-238) post ictus; data from three commercial trials were not shared. ...
Order books on meta-analysis and systematic reviews authored by experts (including Larry Hedges, Terri Pigott, Hannah Rothstein).
Objectives: To assess the accuracy in diagnosing heart failure of clinical features and potential primary care investigations, and to perform a decision analysis to test the impact of plausible diagnostic strategies on costs and diagnostic yield in the UK health-care setting. Data sources: MEDLINE and CINAHL were searched from inception to 7 July 2006. Grey literature databases and conference proceedings were searched and authors of relevant studies contacted for data that could not be extracted from the published papers. Review methods: A systematic review of the clinical evidence was carried out according to standard methods. Individual patient data (IPD) analysis was performed on nine studies, and a logistic regression model to predict heart failure was developed on one of the data sets and validated on the other data sets. Cost-effectiveness modelling was based on a decision tree that compared different plausible investigation strategies. Results: Dyspnoea was the only symptom or sign with high
Brindle, R. C., Ginty, A. T., Phillips, A. C. and Carroll, D. (2014), A tale of two mechanisms: A meta-analytic approach toward understanding the autonomic basis of cardiovascular reactivity to acute psychological stress. Psychophysiology, 51: 964-976. doi: 10.1111/psyp.12248 ...
See related article, pp 642-653. In this issue of the journal, Verdecchia et al1 report an important analysis of the accumulation of evidence comparing more versus less intensive blood pressure (BP)-lowering strategies. Their key message is critical for guidelines and practice internationally: with the addition of SPRINT (Systolic Blood Pressure Intervention Trial),2 this set of trials now provides compelling evidence that more intensive BP-lowering reduces stroke and myocardial infarction (MI), and significant reductions are now also seen in cardiovascular death and heart failure. The authors have also assessed sequential monitoring boundaries for each outcome, making the analogy of a hypothetical Data and Safety Monitoring Board (DSMB) assessing the accumulation of evidence in the field.. Before examining the implications, it is worth reviewing the techniques and aims of the cumulative meta-analysis and trial sequential analysis methods used by Verdecchia et al.1 Cumulative meta-analysis ...
The current study used a convenience sample of 95 SRs included across seven overview topics to provide empirical evidence on issues surrounding quality assessments of SRs in overviews. This study found that AMSTAR assessments and inter-rater reliability were higher for Cochrane compared to non-Cochrane SRs; these results were consistent within each overview topic and for many of the individual questions of the AMSTAR tool. Minor challenges were encountered when assessing quality of SRs in the context of overviews, but decision rules were developed and recommendations for overview authors were provided. Results also suggested that inter-rater reliability of Cochrane and non-Cochrane SRs may be lower for SRs with moderate AMSTAR assessments and higher for SRs that were assessed as strong; inter-rater reliability may also be higher for non-Cochrane SRs assessed as weak. Consistent with a previous study [33], we found that the conclusions, but not the results, of Cochrane and non-Cochrane SRs ...
TY - JOUR. T1 - Meta-analysis of survey data. T2 - Application to health services research. AU - Rao, Sowmya R.. AU - Graubard, Barry I.. AU - Schmid, Christopher H.. AU - Morton, Sally C.. AU - Louis, Thomas A.. AU - Zaslavsky, Alan M.. AU - Finkelstein, Dianne M.. PY - 2008/6/1. Y1 - 2008/6/1. N2 - Traditionally, meta-analysis methods have been developed and used to combine data from several independent clinical trials as well as observational studies, but have not been as widely used in survey research. This paper describes the steps in conducting such a meta-analysis of surveys, to obtain a single summary estimate from a combination of individual-level and summary data. The methods are applied in the context of a project aimed at obtaining an estimate of the prevalence of use of electronic health records.. AB - Traditionally, meta-analysis methods have been developed and used to combine data from several independent clinical trials as well as observational studies, but have not been as ...
OBJECTIVES: To survey the frequency of use of indirect comparisons in systematic reviews and evaluate the methods used in their analysis and interpretation. Also to identify alternative statistical approaches for the analysis of indirect comparisons, to assess the properties of different statistical methods used for performing indirect comparisons and to compare direct and indirect estimates of the same effects within reviews. DATA SOURCES: Electronic databases. REVIEW METHODS: The Database of Abstracts of Reviews of Effects (DARE) was searched for systematic reviews involving meta-analysis of randomised controlled trials (RCTs) that reported both direct and indirect comparisons, or indirect comparisons alone. A systematic review of MEDLINE and other databases was carried out to identify published methods for analysing indirect comparisons. Study designs were created using data from the International Stroke Trial. Random samples of patients receiving aspirin, heparin or placebo in 16 centres were used
Background Four studies previously indicated that the effect of malaria infection during pregnancy on the risk of low birthweight (LBW; ,2,500 g) may depend upon maternal nutritional status. We investigated this dependence further using a large, diverse study population. Methods and findings We evaluated the interaction between maternal malaria infection and maternal anthropometric status on the risk of LBW using pooled data from 14,633 pregnancies from 13 studies (6 cohort studies and 7 randomized controlled trials) conducted in Africa and the Western Pacific from 1996-2015. Studies were identified by the Maternal Malaria and Malnutrition (M3) initiative using a convenience sampling approach and were eligible for pooling given adequate ethical approval and availability of essential variables. Study-specific adjusted effect estimates were calculated using inverse probability of treatment-weighted linear and log-binomial regression models and pooled using a random-effects model. The adjusted risk ...
PART A: META-ANALYSIS METHODOLOGY: THE BASICS Introduction: Meta-analysis: Its Development and Uses Defining Outcome Measures used for Combining via Meta-analysis Random Effects Models for Combining Study Estimates Exploring Between Study Heterogeneity Publication Bias Study Quality Sensitivity Analysis Reporting the Results of a Meta-analysis Fixed Effects Methods for Combining Study Estimates PART B: ADVANCED AND SPECIALIZED META-ANALYSIS TOPICS Bayesian Methods in Meta-analysis Meta Regression Meta-analysis of Different Types of Data Incorporating Study Quality into a Meta-analysis Meta-analysis of Multiple and Correlated Outcome Measures Meta-analysis of Epidemiological and other Observational Studies Generalised Synthesis of Evidence ...
Dear Editor. Having recently published a meta-analysis on the same clinical question,[1] it was with great interest that we read Michael et al.s systematic review of short vs. standard duration antibiotics for urinary tract infections in children.[2] Given the publication (in close succession) of two meta-analyses on the same question with (on the surface) strikingly different results, we thought a comment was in order. First, we applaud the authors on their methodologically sound review. The literature search was explicitly described and exhaustive. In fact, the authors identified a few studies that we had missed.[3-6] The study outcomes for meta-analysis (frequency of positive urine cultures at 0-7 days after treatment and at 10 days to 15 months after treatment, and development of resistant organisms and recurrent UTI) were relevant and clearly defined. The authors provided appropriate and important meta-analysis measures including summary relative risks and a quasi-NNT calculation with ...
T]his is a comprehensive and up-to-date compendium of all relevant aspects for meta-analysis conduction in ecology, evolution, and related topics. Scientists from these areas who already have some knowledge on meta-analysis will find valuable guidance.-Daniela Vetter, Quarterly Review of Biology. A superb guide to the conduct and interpretation of meta-analysis, from an exceptional team of international experts. This comprehensive manual covers essential concepts, steps, and standards for rigorous research synthesis in ecology and evolutionary biology. Its clear prose, helpful illustrations, and worked examples will be useful for beginners and experts alike. Highly recommended for use as a textbook or for self-study.-Julia Littell, Bryn Mawr College, coauthor of Systematic Reviews and Meta-Analysis. This is a well-written and valuable book, one that is unique within biology. The use of meta-analysis in ecology and evolution has reached the point where there is a need for a comprehensive, ...
Accurate representation of ecosystem processes in land models is crucial for reducing predictive uncertainty in energy and greenhouse gas feedbacks with the atmosphere. Here we describe an observational and modeling meta-analysis approach to benchmark land models, and apply the method to the land model CLM4.5 with two versions of belowground biogeochemistry. We focused our analysis on the above and belowground high-latitude ecosystem responses to warming and nitrogen addition, and identified mechanisms absent, or poorly parameterized in CLM4.5. While the two model versions predicted similar trajectories for soil carbon stocks following both types of perturbation, other variables (e.g., belowground respiration) differed from the observations in both magnitude and direction, indicating the underlying mechanisms are inadequate for representing high-latitude ecosystems. The observational synthesis attribute these differences to missing representations of microbial dynamics, characterization of above ...
TY - JOUR. T1 - Correction to. T2 - Epinephrine and short-term survival in cardiogenic shock: an individual data meta-analysis of 2583 patients (Intensive Care Medicine, (2018), 44, 6, (847-856), 10.1007/s00134-018-5222-9). AU - Léopold, Valentine. AU - Gayat, Etienne. AU - Pirracchio, Romain. AU - Spinar, Jindrich. AU - Parenica, Jiri. AU - Tarvasmäki, Tuukka. AU - Lassus, Johan. AU - Harjola, Veli Pekka. AU - Champion, Sébastien. AU - Zannad, Faiez. AU - Valente, Serafina. AU - Urban, Philip. AU - Chua, Horng Ruey. AU - Bellomo, Rinaldo. AU - Popovic, Batric. AU - Ouweneel, Dagmar M.. AU - Henriques, José P.S.. AU - Simonis, Gregor. AU - Lévy, Bruno. AU - Kimmoun, Antoine. AU - Gaudard, Philippe. AU - Basir, Mir Babar. AU - Markota, Andrej. AU - Adler, Christoph. AU - Reuter, Hannes. AU - Mebazaa, Alexandre. AU - Chouihed, Tahar. PY - 2018/11/1. Y1 - 2018/11/1. N2 - Because of a technical error, the code corresponding to the outcome for the Basir et al. cohort was mis-implemented in the ...
Expression quantitative trait loci (eQTLs) analysis is commonly used to identify genetic variants affecting gene regulation. While such studies provide insight into genetic associations, they generally consider only cis-acting SNPs, and fail to address tissue-specific effects that might influence eQTL associations. Here we applied a meta-analysis approach that jointly analyzes cis- and trans-eQTLs. Using data from twelve tissue types from the Genotype-Tissue Expression (GTEx) project V6, we identified hundreds of thousands significant eQTLs in each tissue (FDR , 10%), among which 12% to 42% were trans-eQTLs. By representing the associations between SNPs and genes as links in a bipartite graph, we discovered that these eQTL networks organize into dense, highly modular communities, driven by biological processes. While some communities are enriched for processes relevant to the tissue of origin, other communities can be retrieved in several tissues and are enriched for general functions. We found ...
I am raising my recommendation of 1,000 IU of vitamin D per day to 2,000 IU per day. Since 2005, when I raised it from 400 to 1,000 IU, clinical evidence has been accumulating to suggest that a higher dose is more appropriate to help maintain optimum health.. We have known for many years that we need vitamin D to facilitate calcium absorption and promote bone mineralization. But newer research has shown that we also need it for protection against a number of serious diseases. In recent years, scientists have discovered that it may help to prevent several cancers, cardiovascular disease, autoimmune disorders, psoriasis, diabetes, psychosis, and respiratory infections including colds and flu.. To focus particularly on cancer prevention, two recent meta-analyses (in which data from multiple studies is combined) conducted by the Moores Cancer Center at the University of California at San Diego and colleagues suggested that raising blood levels of vitamin D could prevent one-half of the cases of ...
Introduction: According to the World Health Organization, patient education mainly deals with chronic diseases and conditions which require self care. We know that this practice is still emerging and it is therefore interesting to observe the amount of international research produced in this field during the last years. Objective: We have analysed the quantitative evolution of scientific papers devoted to patient education (PE) over a 10 years period (1999-2009). Methods: Fourty-one chronic diseases and conditions in 11 disciplines have been selected as being the most concerned with patient education (PE). The identification on Pubmed of the studies dealing with these diseases, published from 1999 to 2009, has been undertaken considering the total number of articles mentioning PE activities, the distribution and the evolution in time of PE studies in those disciplines and chronic diseases, the types of publications (reviews, randomized control trials, meta-analyses) on PE. Results: We have ...
This study supports the recommendations by Cochrane Collaboration to prioritize MEDLINE, EMBASE and CENTRAL as the basic databases for literature search to locate RCTs in the musculoskeletal area. Secondly, this study indicates that besides MEDLINE, EMBASE and CENTRAL a literature search to locate RCTs in the musculoskeletal area could also consider SCOPUS and CINAHL. Finally, this study indicates that even with the addition search of 10 other often used databases median recall is not improved noticeably.. Thirteen different databases were not enough to identify all relevant references. Searching MEDLINE, EMBASE and CENTRAL retrieved 88.9%, and searches in 10 additional databases increased the median recall by only 2 percentage point. Thus, results from this study could be interpreted, as an indication that searching databases is not sufficient to identify all relevant references and that other sources must be included in the literature search in order to achieve a larger recall. This study does ...
Systematic reviews and meta-analyses are the best approaches available for summarizing the available evidence concerning the efficacy of therapies. Although the renal field has been slow to use these techniques, they are being used increasingly. In March 1997, the Cochrane Renal Group was formed, and this group aims to produce and maintain up to date systematic reviews of the evidence on the effectiveness of therapies used to treat patients with renal diseases. This group is part of the Cochrane Collaboration which is an international structure grouping collaborators together, with the aim of preparing, maintaining and disseminating systematic reviews of the effects of health care in all areas of medicine.. ...
To our knowledge, this is the first systematic review with cohort analysis and meta-analysis that has evaluated the role of WHO group 5 drugs in the treatment of fluoroquinolone-resistant MDR-TB and XDR-TB and with emphasis on the strength of association rather than statistical significance. We have systematically collected individual patient data from 20 articles in English to assemble a cohort of 194 fluoroquinolone-resistant MDR-TB patients treated with WHO group 5 drugs. Statistical analyses showed neither between-study heterogeneity nor publication bias. Both cohort analysis using robust Poisson regression models and meta-analysis using random-effects models showed that use of linezolid substantially and significantly increased the probability of favorable outcome by 50% to 60%. Defining clinically significant improvement by risk ratios ≥ 1.2 or ≤ 0.9, neither cohort analysis nor meta-analysis demonstrated any add-on benefit from the use of the other group 5 drugs (high-dose isoniazid, ...
Whether PWA increases risk of infection or severe outcomes from COVID-19 remains unclear. There is no consensus from systematic reviews, and high quality primary studies report conflicting results in some areas. Within PWA with COVID-19, people with co-morbid COPD and people with non-allergic asthma appear more vulnerable to worse outcomes. Older age and non-white ethnicity also appear to confer greater risk within PWA, as would be expected from data from the general population. Data on asthma medication use is difficult to interpret due to inconsistent findings across primary studies and possible confounding/co-linearity between asthma severity and medication prescribed, though the largest study of its type found that ICS use was associated with higher mortality risk in PWA.(22) Further primary studies and comprehensive meta-analyses are needed.. As well as - and perhaps linked to- the conflicting and imprecise results noted above, there a number of other important limitations to evidence in ...
Although recent meta-analyses of the HIV prevention intervention literature have demonstrated that behavioral interventions reduce sexual risk-taking among men who have sex with men (MSM), interventions for not-in-treatment substance using MSM are lacking. Consequently, and based upon overwhelming evidence that substance use is a primary driver of HIV infection among urban MSM, public health authorities have identified the development of efficacious interventions for substance using MSM as a concern of the highest priority. The proposed study aims to test a new intervention based upon psychological empowerment theory that, in preliminary field tests, produced high levels of acceptability and participation, as well as large reductions in sexual risks and substance use, among a sample of ethnically-diverse, high risk, substance using, HIV+ and -negative MSM. The intervention to be tested is based upon a theory of MSM health risk behaviors that posits that urban gay fast lane subcultures present ...
Although recent meta-analyses of the HIV prevention intervention literature have demonstrated that behavioral interventions reduce sexual risk-taking among men who have sex with men (MSM), interventions for not-in-treatment substance using MSM are lacking. Consequently, and based upon overwhelming evidence that substance use is a primary driver of HIV infection among urban MSM, public health authorities have identified the development of efficacious interventions for substance using MSM as a concern of the highest priority. The proposed study aims to test a new intervention based upon psychological empowerment theory that, in preliminary field tests, produced high levels of acceptability and participation, as well as large reductions in sexual risks and substance use, among a sample of ethnically-diverse, high risk, substance using, HIV+ and -negative MSM. The intervention to be tested is based upon a theory of MSM health risk behaviors that posits that urban gay fast lane subcultures present ...
Lithium has already shown value as an augmentation agent in Major Depression: in recent meta-analyses, augmentation with lithium was nearly 3 times more likely to produce a response than placebo.7,8 Forty percent showed response versus 14.4% in the placebo group, for a number needed to treat (NNT) of 5: youd need to treat 5 patients with lithium to see an effect of statistical magnitude; a less pronounced effect could be seen in even fewer patients.7 True, the antidepressants in these studies were mostly tricyclics, though 3 of 9 studies used SRIs8; do we have to wait for yet more studies with newer antidepressants? I think the Finnish population data, while they do not specify an NNT, are compelling-especially given the size of the effect seen (50% lower rehospitalization rate). As advocated in the most recent review,9 if my patient was hospitalized with severe depression, and there were no contraindications, shed likely leave on lithium-regardless of how bipolar she is ...
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Contains a new chapter on microcirculation The already existing chapters have been rearranged and updated on the basis of the most recent meta-analyses
Multilevel network meta-regression for population adjustment based on individual and aggregate level data. Abstract: Standard network meta-analysis (NMA) and indirect comparisons combine aggregate data (AgD) from multiple studies on treatments of interest, assuming that any effect modifiers are balanced across populations. We can relax this assumption if individual patient data (IPD) are available from all studies by fitting an IPD meta-regression. However, in many cases IPD are only available from a subset of studies. In the simplest scenario, IPD are available for an AB study but only AgD for an AC study. Methods such as Matching Adjusted Indirect Comparison (MAIC) create a population-adjusted indirect comparison between treatments B and C. However, the resulting comparison is only valid in the AC population without additional assumptions, and the methods cannot be extended to larger treatment networks. Meta-regression-based approaches can be used in larger networks. However, these typically ...
This study provides evidence that the combined use of RAS inhibitors and statins may be associated with greater anticancer effects than use of either class of drugs in isolation. To explain this phenomenon, our animal data indicated that RAS blockade prevented the development of renal cell carcinoma in UNX rats via normalizing the expression of the HMGCR and IGF-1 signaling pathways.. The risk associations of statin use and cancer remain controversial. In epidemiological studies, the use of statins was associated with a large relative risk reduction for cancer (37). Conversely, nearly all meta-analyses of clinical trials (13,38) showed that statins have a neutral effect on incidence of cancer. However, results from meta-analyses are often inconclusive because of heterogeneity of study design, clinical profile of patient cohorts, different definitions for outcome measures, and quality of data. This statement is illustrated by the marked variations in cancer incidence ranging from 0.2 to 6.3% in ...
BioScience Laboratories, Inc. has always been capable in the realm of bio-statistics, and now we offer a new service: meta-analysis. Meta-analysis is the process of integrating the data from multiple individual studies performed by different technicians at different times at different laboratories into one unified study.. By using meta-analysis, you can have the various non-FDA studies performed on your product integrated into one study to make sense of the results. This is important, for example, when one researcher finds your product to be very good, and another finds it to be not acceptable. Instead of favoring one researcher and discounting the other, meta-analysis integrates all the studies results into one final result.. For FDA studies, you likely will have performed more than one study on your product. Perhaps two studies were done, one pivotal and the other, confirmatory. Meta-analysis can integrate the results from these for inclusion in your FDA submission packet.. To learn more ...
Due to the rapid spread of coronavirus disease 2019 (COVID-19) worldwide, it is necessary to ascertain essential immune inflammatory parameters that describe the severity of the disease and provide guidance for treatment. We performed network meta-analyses to determine differences in blood cells, lymphocyte subsets, and cytokines in COVID-19 patients with different clinical stages. Databases were systematically searched to May 2, 2020, and updated on June 1, 2020. Network meta-analyses were conducted via Stata 15.0, and the mean difference (MD) and its 95% CI were used as the effect values of the pooled analysis. Seventy-one studies were included involving 8647 COVID-19 patients, White blood cell (WBC), neutrophil (NEUT), IL-6, and IL-10 counts increased significantly with worsening of the COVID-19, while lymphocyte (LYM) counts decreased. The levels of platelet (PLT), CD3+, CD4+, CD8+, and CD19+ cells in severe and critical patients were significantly lower than those in mild patients. IL-1β count was
The heterogeneity test identified no significant cross-study heterogeneity, and the results of cumulative meta-analysis, sensitivity analysis, and the publication bias test verified the reliability of our study ...
Health,... NOVATO Calif. Sept. 27 /- BioMarinPharma... This meta-analysis stresses the importance of early and continuous Ph...Highlights from the meta-analysis are summarized below: ...-- Significant proportional correlations were found during critical/...,Meta-Analysis,of,Blood,Phe,Levels,and,Clinical,Outcomes,in,PKU,Published,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
PubMed journal article Comparative tolerability and harms of individual statins: a study-level network meta-analysis of 246 955 participants from 135 randomized, controlled trial were found in PRIME PubMed. Download Prime PubMed App to iPhone or iPad.
A Systematic Review and Meta-Analysis". PLOS ONE. 9 (7): e101320. doi:10.1371/journal.pone.0101320. PMC 4106761. PMID 25051345. ... Urology - Health Topics/Urodynamic Testing".. *^ de Jong, Y; Pinckaers, JH; Ten Brinck, RM; Lycklama À Nijeholt, AA; Dekkers, ... storing and releasing urine analysis. Urodynamic testing or urodynamics is a study that assesses how the bladder and urethra ...
Lilly M, Godwin M (Apr 2009). "Treating prediabetes with metformin: systematic review and meta-analysis". Canadian Family ... UptoDate: Prediction and prevention of type 2 diabetes mellitus; www.utdol.com/utd/content/topic.do?topicKey=diabetes. ... systematic review and meta-analysis of screening tests and interventions". BMJ (Clinical research ed.). 356: i6538. doi:10.1136 ... systematic review and meta-analysis". BMJ: i5953. doi:10.1136/bmj.i5953. PMC 5121106 . PMID 27881363.. ...
... a meta-analysis". Am J Clin Nutr. 69 (1): 30-42. doi:10.1093/ajcn/69.1.30. PMID 9925120.. ... In: Spiller GA (ed) Topics in dietary fiber research. Plenum Press, New York, pp. 127-68 ...
... a meta-analysis". The American Journal of Clinical Nutrition. 69 (1): 30-42. doi:10.1093/ajcn/69.1.30. PMID 9925120.. ... In: Spiller GA (ed) Topics in dietary fiber research. Plenum Press, New York, pp. 127-68 ... an umbrella review of systematic reviews and meta-analyses". The American Journal of Clinical Nutrition. 107 (3): 436-444. doi: ... a series of systematic reviews and meta-analyses". Lancet. 393 (10170): 434-445. doi:10.1016/S0140-6736(18)31809-9. PMID ...
127-68 Brown L, Rosner B, Willett WW, Sacks FM (January 1999). "Cholesterol-lowering effects of dietary fiber: a meta-analysis ... In: Spiller GA (ed) Topics in dietary fiber research. Plenum Press, New York, pp. ... an umbrella review of systematic reviews and meta-analyses". The American Journal of Clinical Nutrition. 107 (3): 436-444. doi: ... a series of systematic reviews and meta-analyses". Lancet. 393 (10170): 434-445. doi:10.1016/S0140-6736(18)31809-9. PMID ...
... systematic review and meta-analysis of randomised trials". BMJ. 358: j3887. doi:10.1136/bmj.j3887. PMC 5605780. PMID 28931508. ... ISBN 978-0-323-05472-0. "Sore Throat and Other Throat Problems-Topic Overview". Shaikh N, Leonard E, Martin JM (September 2010 ... a meta-analysis". Pediatrics. 126 (3): e557-64. doi:10.1542/peds.2009-2648. PMID 20696723. S2CID 8625679. "Group A Strep , ...
The majority of studies are small size case studies or meta-analysis. The most extensive research study to date was ... The lead researcher Jerad Gardner spoke at a Ted Talk in February 2020 on the topic. Taylor, RW, in 1890. first identified DFSP ... an analysis of 12,114 cases". Cancer. 113 (3): 616-627. doi:10.1002/cncr.23571. ISSN 0008-543X. PMID 18618615. S2CID 23746544. ... A clinicopathologic analysis of patients treated and followed at a single institution". Cancer. 88 (12): 2711-2720. doi:10.1002 ...
... a meta-analysis". Dev Med Child Neurol (Meta-analysis). 51 (5): 340-49. doi:10.1111/j.1469-8749.2008.03244.x. PMID 19379289.. ... "Topics in complementary and alternative therapies (PDQ)". National Cancer Institute, National Institutes of Health. PMID ... a systematic review and meta-analysis". Dev Med Child Neurol (Meta-analysis). 53 (9): 783-92. doi:10.1111/j.1469-8749.2011. ... A meta-analysis". J Gen Intern Med. 20 (12): 1151-58. doi:10.1111/j.1525-1497.2005.0243.x. PMC 1490287. PMID 16423108.. ...
... a systematic review and meta-analysis". Otology & Neurotology. 35 (6): 1033-1045. doi:10.1097/MAO.0000000000000324. ISSN 1537- ... "GMS Current Topics in Otorhinolaryngology, Head and Neck Surgery. 4: Doc05. PMC 3201005. PMID 22073053.. ...
... a systematic review and meta-analysis". Eur. J. Cancer. 41 (13): 2023-32. doi:10.1016/j.ejca.2005.05.010. PMID 16084719. "CDC ... Cancer Policy - NIOSH Workplace Safety and Health Topic". www.cdc.gov. Retrieved 2016-02-12. "Occupational Cancer". National ...
A meta-analysis of thirty-seven studies that examined relationships between the Moon's four phases and human behavior revealed ... List of topics characterized as pseudoscience Astrology Human menstrual cycle Menstrual synchrony Reproductive synchrony ... This has allowed several extensive literature reviews and meta-analyses to be produced, which have found no correlation between ... A meta-analysis of lunar-lunacy research". Psychological Bulletin. 97 (2): 286-306. doi:10.1037/0033-2909.97.2.286. ISSN 1939- ...
A meta-analysis of 36 studies". Arch Gen Psychiatry. 68 (7): 724-731. doi:10.1001/archgenpsychiatry.2011.74.. ... Current Topics in Behavioral Neurosciences. 6. pp. 141-56. doi:10.1007/7854_2010_91. ISBN 978-3-642-15130-9. PMC 3599773. PMID ... a meta-analysis of VBM studies". BMC Psychiatry. 13: 110. doi:10.1186/1471-244X-13-110. PMC 3664070. PMID 23570420.. ... a systemic review and meta-analysis". European Eating Disorders Review. 22 (2): 92-101. doi:10.1002/erv.2271. PMID 24277724.. ...
Meta-analysis is the preferred technique of quantitative research synthesis in many fields, such as medical science. This ... It aims to generate new knowledge by combining and comparing the results of multiple studies on a given topic. One approach is ... Narrative synthesis allows researchers to address a wide range of questions in their review, while meta-ethnography aims to ... Methods of qualitative research synthesis include narrative synthesis and meta-ethnography. ...
In their 2013 meta-analysis, Fawcett et al. (2013) presented the issues surrounding the arousal/threat hypothesis. This is one ... This finding adds to the ecological validity of the laboratory studies conducted on this topic. One reason why this effect's ... Even so, a recent meta-analysis conducted by Fawcett et al. (2013) has demonstrated that when the data for all of the applied ... They show great promise that weapon focus effect and be counteracted by education on the topic, but they will remain ...
The meta-analyses conducted by Alfieri and colleagues reconfirmed such findings. Mayer (2004) argues that unassisted discovery ... Bruner also cautioned that such discovery could not be made prior to or without at least some base of knowledge in the topic. ... According to a meta-analytic review conducted by Alfieri, Brooks, Aldrich, and Tenenbaum (2011), a discovery learning task can ... Kirschner, P. A.; Sweller, J. & Clark, R. E. (2006). "Why minimal guidance during instruction does not work: an analysis of the ...
Discourse Markers as Indicators of Text Structure in the multiple-topic Qur'anic suras: a meta-analysis of Q:2. Journal of ... El-Awa provides a detailed analysis in terms of coherence theory on chapters 33 and 75 and shows that these two chapters cohere ...
Sherris[citation not found] Ternhag A, Asikainen T, Giesecke J, Ekdahl K (2007). "A meta-analysis on the effects of antibiotic ... "Campylobacter". Health Topics A TO Z. Retrieved 6 March 2011. ...
... a trial sequential meta-analysis". The Lancet Diabetes & Endocrinology (Meta-analysis). 2 (4): 307-20. doi:10.1016/S2213-8587( ... Emerging and Evolving Topics in Multiple Sclerosis Pathogenesis and Treatments. Current Topics in Behavioral Neurosciences. 26 ... One meta-analysis found a decrease in mortality in elderly people.[12] Another meta-analysis covering over 350,000 people ... A 2012 meta-analysis showed that the risk of cardiovascular diseases increases when blood levels of vitamin D are lowest in a ...
A Systematic Review and Meta-Analysis. Available at SSRN 3208968. *^ Nadimpalli, M., Rinsky, J. L., Wing, S., Hall, D., Stewart ... Retrieved from: https://www.frontiersin.org/research-topics/6689/livestock-associated-staphylococcus-aureus-la-mrsa ... Risk Analysis: An Official Publication of the Society for Risk Analysis. 28 (3): 695-710. doi:10.1111/j.1539-6924.2008.01054.x ... Hu, X.; Zhou, Q.; Luo, Y. (2010). "Occurrence and source analysis of typical veterinary antibiotics in manure, soil, vegetables ...
replied that Spiegel misrepresented their analysis, since they did not use Landis' study in the meta-analysis of childhood ... The APA mandated a policy change by which APA journal editors would alert the organization of potentially controversial topics ... meta-analysis, can be interpreted as providing a hopeful and positive message to therapists, parents, and children. Child ... Anna Salter comments that Rind et al.'s results are "truly an outlier" compared to other meta-analyses. The Rind paper has been ...
To set a minimum standard for the paper's results to be included in a meta analysis. A researcher conducting a systematic ... review for example might elect to exclude all papers on the topic with a Jadad score of 3 or less. For critical analysis of an ... Lancaster T, Stead L (1999). Dealing with drop-outs in clinical trials and meta-analyses. 7th Best Evidence Health Care ... ISBN 978-1-4051-3266-4. Chow, Shein-Chung; Liu, Jen-pei (2004). Design and Analysis of Clinical Trials. Wiley. p. 2. ISBN 978-0 ...
Rhoades and Eisenberger's meta-analysis covered some 70 POS studies carried out through 1999, and over 300 studies have been ... Although there were relatively few studies of POS until the mid-1990s, research on the topic has burgeoned in the last few ... The meta-analysis found clear and consistent relationships of POS with its predicted antecedents and consequences. The three ... There are many possible consequences of POS discussed in Eisenberger and Rhoade's meta-analysis of studies done on POS. The ...
Summarizing studies and meta-analysis remain scarce due to the amount of data involved. Max Marwick, John Middleton, Mary ... a confusion of topics. Another common parlance refers to political persecution in general as "witch-hunt", an example were the ... Anthropology and History in the Analysis of Witchcraft Beliefs of the Maka (Southeast Cameroon). In: Schefold, Schoorl and ...
Wood, W., & Quinn, J. M. (2003). Forewarned and forearmed? Two meta-analysis syntheses of forewarnings of influence appeals. ... Specific research topics in Woods' lab include how and why people fall back into old habits, how good patterns help people meet ... She has thus produced numerous highly authoritative meta-analyses of social psychological phenomena. In addition to her ... Wood, W., & Eagly, A. H. (2002). A cross-cultural analysis of the behavior of women and men: Implications for the origins of ...
Hwang, Y; Jeong, S-H. (2009). "Revisiting the knowledge gap hypothesis: A meta-analysis of thirty-five years of research". ... People with greater education also tend express interest in, and expose themselves to, a broader range of topics, including ... At least two narrative reviews and one meta-analysis of knowledge gap hypothesis research exist. Gaziano conducted two ... Because narrative reviews examine significance tests rather than effect sizes, Hwang and Jeong (2009) conducted a meta-analysis ...
Meta-analyses have been used to aggregate data (modern approaches to meta-analyses rely on HLM), and draw conclusions across ... Research topics[edit]. Important theoretical models in OHP research[edit]. Three influential theoretical models in OHP research ... a b c Paul, K. I., & Moser, K. (2009). Unemployment impairs mental health: Meta-analyses. Journal of Vocational Behavior, 74, ... A literature review and meta-analysis links high demands, low control, and low support to clinical depression.[112] A meta- ...
It is usually best to use reviews and meta-analyses where possible, as these give a balanced and general perspective of a topic ... The "Limits" tab can further limit the search, for example, to meta-analyses, to freely readable sources, and/or "core clinical ... In medicine, primary sources include clinical trials, which test new treatments; secondary sources include meta-analyses, which ... To create a new topic, slick [new section] at the top of the page, give the section a title, and leave your comment. New topics ...
Therefore, one should carry out an analysis of all studies on one topic and correct for artifacts, leading to a strong increase ... Jan te Nijenhuis, Kenya Kura, Yoon-Mi Hur (2014) The correlation between g loadings and heritability in Japan: A meta-analysis ... 2007), one can use psychometric meta-analysis to negate this problem. Second, Jensen's MCV has been criticized with regards to ... 2004) is not without limitations: A principle of meta-analysis is that the amount of information contained in one individual ...
Published examples that are used in meta analysis are of variable quality with omissions. However, the number of empirical ... such as those used in other kinds of network analysis (e.g., graph theory), to study emergent patterns and properties shared ... Ecologists identify feeding relations and organize species into trophic species through extensive gut content analysis of ... "Compilation and Network Analyses of Cambrian Food Webs". PLOS Biology. 6 (4): e102. doi:10.1371/journal.pbio.0060102 ...
... had been assessed with a meta-analysis.[112] According to a 2005 book by a US Institute of Medicine panel, the number of RCTs ... teaching includes such topics as doctor-patient communication, ethics, the art of medicine,[96] and engaging in complex ... Ernst, E. (2008). "Placebo and other Non-specific Effects". In Ernst, E. (ed.). Healing, Hype, or Harm? A Critical Analysis of ... An analysis of the conclusions of only the 145 Cochrane reviews was done by two readers. In 83% of the cases, the readers ...
For the discipline of topology, which topics can be included and excluded? If a topic appears in Munkres' Topology, then one ... Meta learning (computer science) Done. *Michael Roberts (mathematician) → Covariant Done (see next thread) D.Lazard (talk) 09: ... For example, the discipline of topology heavily overlaps with geometry, analysis, algebra, etc. And Wikipedia should explain ... What should 'big topic' articles like this cover? Is there any thing that you feel is necessary or standard for such articles? ...
... through the use of systematic reviews and meta-analysis. The movement is facilitated by modern global information science, ... The medical decision-making (MDM) process involves analysis and synthesis of all the above data to come up with a list of ... is an aspect of health services concerned with threats to the overall health of a community based on population health analysis ...
A Comparative Effectiveness Meta-Analysis". Spine (Meta-analysis). 39 (7): E463-72. doi:10.1097/BRS.0000000000000230. PMID ... List of topics characterized as pseudoscience. *Chiropractic education. *Chiropractic schools. *Councils on Chiropractic ... A 2011 systematic review and meta-analysis concluded that the addition of manual mobilizations to an exercise program for the ... A 2013 systematic review and meta-analysis found a statistically significant improvement in overall recovery from sciatica ...
"meta-synthesis.com. Retrieved 6 April 2012.. *^ a b Kaner, Richard (2003). "C&EN: It's Elemental: The Periodic Table - Cesium" ... Topics in Current Chemistry. 124/1984. pp. 91-133. doi:10.1007/3-540-13534-0_3. ISBN 978-3-540-13534-0. .. ... "Chemical risk analysis: a practical handbook. p. 215. ISBN 978-1-903996-65-2. .. ... MacPherson, H. G. (1934). "An Investigation of the Magneto-Optic Method of Chemical Analysis". Physical Review. American ...
Random-restart hill climbing is a meta-algorithm built on top of the hill climbing algorithm. It is also known as Shotgun hill ... In numerical analysis, hill climbing is a mathematical optimization technique which belongs to the family of local search. It ... Wikibooks has more on the topic of: Hill climbing. Retrieved from "https://en.wikipedia.org/w/index.php?title=Hill_climbing& ...
The first part of their analysis (which the only relevant part to this section) was not meant to discover the types of free ... Randolph Clarke (1996). "Agent Causation and Event Causation in the Production of Free Action". Philosophical Topics. 24 (2): ... Without entering into metaphysical speculations, I may perhaps add that an analysis of the very concept of explanation would, ... Using functional magnetic resonance imaging with specialized multivariate analyses to study the temporal dimension in the ...
Pittler MH, Ernst E (2000). "Efficacy of kava extract for treating anxiety: systematic review and meta-analysis". Journal of ... A. Kumar; A.G.C. Nair; A.V.R. Reddy; A.N. Garg (2005). "Analysis of essential elements in Pragya-peya-a herbal drink and its ... constituents by neutron activation". Journal of Pharmaceutical and Biomedical Analysis. 37 (4): 631-828. doi:10.1016/j.jpba. ...
The role of a public intellectual can lead to the individual placing himself in danger as he engages with disputed topics. In ... Also important is Sartre's analysis of psychological concepts, including his suggestion that consciousness exists as something ... Related topics. *Axiology. *Cosmology. *Epistemology. *Feminist metaphysics. *Interpretations of quantum mechanics. *Meta- ...
"Meta-analysis of Brazilian genetic admixture and comparison with other Latin America countries". American Journal of Human ...
A systematic review and meta-analysis". Oncol. Nurs. Forum. 40 (2): 163-170. doi:10.1188/13.onf.163-170. ISSN 0190-535X. PMID ... a longitudinal analysis". Pharmacotherapy. 27 (9): 1237-47. doi:10.1592/phco.27.9.1237. PMID 17723077. S2CID 3905654.. ...
Participant performance is a key component during the analysis phase. However, performance can often be a difficult topic to ... a systematic review and meta-analysis. Medical Education, 48, 657-666. DOI: 10.1111/medu.12432 ... AnalysisEdit. The second phase of debriefing is often referred to as "analysis,"[1][13][29][28][22] "description,"[30] or " ... A process which draws these beliefs & ideas out, with the intent of re-examining & re-testing them against a topic in order to ...
A Meta-Analysis of the Antecedents and Outcomes of Corporate Political Activity". Journal of Management. Retrieved November 26, ... or argumentative essay that states a Wikipedia editor's personal feelings or presents an original argument about a topic. ... A 2011 meta-analysis of previous research findings found a positive correlation between corporate political activity and firm ... reports and analysis on the lobbying industry ...
A Systematic Review and Meta-Analysis". PLOS ONE. 8 (9): e72484. doi:10.1371/journal.pone.0072484. PMC 3759386. PMID 24023744. ... numerous studies and recent large-scale meta-analysis cast serious doubt on claims made about the ability of psychopathy ... "Violence risk meta-meta: Instrument choice does matter: Despite popularity, psychopathy test and actuarials not superior to ... Yang, M; Wong, SC; Coid, J (September 2010). "The efficacy of violence prediction: a meta-analytic comparison of nine risk ...
... a meta analysis". J Clin Exp Neuropsychol (Meta-analysis) 34 (9): 989-98. PMID 22913619. doi:10.1080/13803395.2012.712676. Cite ... http://www.nia.nih.gov/alzheimers/topics/symptoms. pristupljeno 28 December 2011. ... Greater cognitive deterioration in women than men with Alzheimer's disease: a meta analysis. Journal of Clinical and ... a systematic analysis for the Global Burden of Disease Study 2010.". Lancet 380 (9859): 2095-128. PMID 23245604. doi:10.1016/ ...
Phaladhikaranam, Topic 8, Sutras 38-41.. *^ Thompson, GJ; Hurd, PL; Crespi, BJ (2013). "Genes underlying altruism". Biol Lett. ... Two related strands of research on altruism have emerged from traditional evolutionary analyses and from evolutionary game ... by analysis of other-regard within creative individuation of the self, and by contrasting love for the few with love for the ... and has become a major topic for psychologists (especially evolutionary psychology researchers), evolutionary biologists, and ...
Brachman, Ronald J. (1983); What IS-A is and isn't: An analysis of taxonomic links in semantic networks, IEEE Computer, vol. 16 ... Meta-Object Facility (MOF), a different standard for the Unified Modeling Language (UML) of the Object Management Group (OMG) ... Annotations carry machine and human oriented meta-data. Information about the classes, properties and individuals that compose ... Related topics. *Collective intelligence. *Description logic. *Folksonomy. *Geotagging. *Information architecture. *Knowledge ...
"How much do we think about thinking? Science of Meta-awareness and Mind-wandering". Bridging the Gaps: A Portal for Curious ... This effect was somewhat counteracted by people's tendency to mind-wander to happy topics, but unhappy mind-wandering was more ... mind wandering reduces cortical analysis of the task environment". Journal of Cognitive Neuroscience. 20 (3): 458-469. doi: ... The experience of thoughts not remaining on a single topic for a long period of time ...
... a meta-analysis". Journal of Travel Medicine. 13 (3): 127-132. doi:10.1111/j.1708-8305.2006.00029.x. ISSN 1195-1982. PMID ... "CDC - Aircrew Safety and Health - Cosmic Ionizing Radiation - NIOSH Workplace Safety & Health Topics". www.cdc.gov. 2018-11-08 ... labour performed by flight attendants and cross-cultural aspects of it have since been actively studied and are a topic of ...
... meta-analysis". Frontiers in Human Neuroscience. 7: 548. doi:10.3389/fnhum.2013.00548. PMC 3762365. PMID 24027520.. CS1 maint: ... Topics. *Brain-computer interface. *Brain regions. *Clinical neuropsychology. *Cognitive neuroscience. *Human brain ...
... a systematic review and meta-analysis". CMAJ : Canadian Medical Association 183 (3): 310-9. doi:10.1503/cmaj.092129. பப்மெட்: ... https://web.archive.org/web/20110917205243/http://www.ebmedicine.net/topics.php?paction=showTopic&topic_id=118. ...
Discourse analysis. *Environmental communication. *Global communication. *Health communication. *International communication. * ...
A Systematic Review and Meta-Analysis". PLOS One. 10 (5): e0126971. doi:10.1371/journal.pone.0126971. PMC 4440710. PMID ... an ESS analysis". Journal of Evolutionary Biology. 17: 1035-1047. doi:10.1111/j.1420-9101.2004.00751.x.. ... Topics. *Evolution of eusociality. *Presociality. *Social insects *Gamergate. *Group selection. *Haplodiploidy. *Identity in ... "Morphometric analysis and biogeography of Apis koschevnikovi Enderlein (1906)". Apidologie. 39 (5): 495-503. doi:10.1051/apido ...
A systematic review and meta-analysis". The Laryngoscope. 123 (1): 197-203. doi:10.1002/lary.23551. ISSN 1531-4995. PMID ... "Gms Current Topics in Otorhinolaryngology, Head and Neck Surgery. 12: Doc01. doi:10.3205/cto000093. PMC 3884536. PMID 24403969. ... Bohlender, Jörg (2013). "Diagnostic and therapeutic pitfalls in benign vocal fold diseases". GMS Current Topics in ... "GMS , GMS Current Topics in Otorhinolaryngology - Head and Neck Surgery , Diagnostic and therapeutic pitfalls in benign vocal ...
A second meta-analysis found no effect on the risk of prostate cancer.[35] Two meta-analyses evaluated the effect of vitamin C ... started publishing research on the topic and also published a book "Vitamin C and the Common Cold" in 1970.[28] A revised and ... a meta-analysis and meta-regression". Cancer Causes & Control. 22 (10): 1383-96. doi:10.1007/s10552-011-9811-y. PMID 21761132. ... A meta-analysis of 44 clinical trials has shown a significant positive effect of vitamin C on endothelial function when taken ...
... a systematic review and meta-analysis". Infectious Diseases of Poverty. 7 (1): 44. doi:10.1186/s40249-018-0434-3. PMC 5956617. ... Scholia has a topic profile for Cholangiocarcinoma.. *American Cancer Society Detailed Guide to Bile Duct Cancer. ... A systematic review with a meta-analysis of observational studies". Cancer Treat Rev. 38 (2): 111-119. doi:10.1016/j.ctrv. ... Analysis of 100 patients". Annals of Surgery. 235 (3): 392-9. doi:10.1097/00000658-200203000-00011. PMC 1422445. PMID 11882761. ...
... used for medical meta-analyses reviewed 29 meta-analyses and found that COIs in the studies underlying the meta-analyses were ... researchers from different areas who are brought together for several days of intensive discussions about a particular topic ... "How Well Do Meta-Analyses Disclose Conflicts of Interests in Underlying Research Studies". The Cochrane Collaboration website. ... The 29 meta-analyses reviewed an aggregate of 509 randomized controlled trials (RCTs). Of these, 318 RCTs reported funding ...
... systematic review and meta-analysis of observational studies.". The Lancet infectious diseases 9 (2): 118-29. PMID 19179227. ... Walker, BD (2007 Aug-Sep). "Elite control of HIV Infection: implications for vaccines and treatment.". Topics in HIV medicine ... systematic review and meta-analysis of observational studies". The Lancet Infectious Diseases 9 (2): 118-129. PMID 19179227. ... systematic review and meta-analysis". BMJ 345 (oct03 3): e5945-e5945. doi:10.1136/bmj.e5945.. ...
A meta-analysis can be downloaded at the website of the Journal sozialpolitik.ch, Volume 2/2016, pp. 1-24 (charges may apply ... Top-ics. Sub-navigation items. Focus. Overall Research Project Mental Health in the Working World ... A meta-analysis. The complete article "The impact of supplementary short rest breaks on task performance - A meta-analysis" can ... The impact of supplementary short rest breaks on task performance - A meta-analysis. in: sozialpolitik.ch, Volume 2/2016 2016. ...
Meta-Analysis; Research Support, Non-U.S. Govt ... TOPIC: Preoperative corneal neovascularization (CNV) is thought ... Corneal neovascularization as a risk factor for graft failure and rejection after keratoplasty: an evidence-based meta-analysis ... Results were reported both descriptively for each study and using random effects meta-analysis. Potential moderating factors ... for the association between vascularization and graft failure and rejection were examined using metaregression analysis. ...
What is already known on this topic. *. Evidence suggests that both traditional and cyclo-oxygenase-2 selective non-steroidal ... Statistical analysis. The available data for the IPD meta-analysis were gathered at two levels. At the higher level of analysis ... This led to the final set of target confounders (or IPD meta-analysis confounders) selected for adjustment in the meta-analysis ... Project meta-analysis of observational studies36 are overall lower than those of our IPD meta-analysis. In accordance with most ...
Effect of dietary fatty acids on serum lipids and lipoproteins-a meta-analysis of 27 trials. Arterioscler Thromb 1992;12:911-9. ... We conducted a meta-analysis of 395 published, metabolic ward experiments of the effects of various dietary lipids on blood ... Dietary lipids and blood cholesterol: quantitative meta-analysis of metabolic ward studies BMJ 1997; 314 :112 ... Design: Meta-analysis of metabolic ward studies of solid food diets in healthy volunteers. ...
Topics. Public Economics. National Fiscal Issues. Health, Education, and Welfare. Health. Programs. Health Care. Health ... Assessing the Age Specificity of Infection Fatality Rates for COVID-19: Systematic Review, Meta-analysis, & Public Policy ...
Topics * All Topics Biotechnology Biotech Business Biotech Products Cancer Cardiovascular Dermatology Drug Discovery ... The authors performed a meta-analysis to study the incidence of nonunion and symptomatic malunion and test the hypothesis that ... Topics. All Topics Biotechnology Biotech Business Biotech Products Cancer Cardiovascular Dermatology Drug Discovery ... Operative Versus Nonoperative Outcomes of Middle-Third Clavicle Fractures: A Systematic Review and Meta-Analysis.. 07:00 EST ...
Topics * All Topics Biotechnology Biotech Business Biotech Products Cancer Cardiovascular Dermatology Drug Discovery ... Network Meta-analysis. Meta-analysis of randomized trials in which estimates of comparative treatment effects are visualized ... A meta-analysis and systematic review of clinical randomized trials.". Ginseng is a widely used ingredient in several ... A meta-analysis and systematic review of clinical randomized trials.. 08:00 EDT 14th July 2019 , BioPortfolio ...
Seroevidence for H5N1 Influenza Infections in Humans: Meta-Analysis. T. Wang et al. ...
OR review literature as topic[MeSH Terms] OR review[Text Word]) NOT (case reports[Publication Type]). ... Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in ... Meta-analysis: Travel and Risk for Venous Thromboembolism Free Divay Chandra, MD, MSc; Emilio Parisini, MSc, PhD; Dariush ... As in any meta-analysis that uses grouped data from separate published studies, we cannot be certain that our estimates are ...
Time-to-event meta-analyses showed that the relative hazard for all-cause mortality in the first 3 months after hip fracture ... Meta-analysis: Excess Mortality After Hip Fracture Among Older Women and Men Patrick Haentjens, MD, PhD; Jay Magaziner, PhD; ... Meta-analysis: Excess Mortality After Hip Fracture Among Older Women and Men. Ann Intern Med. 2010;152:380-390. doi: 10.7326/ ... carry out a life-table analysis, and display the survival curves of the hip fracture group and age- and sex-matched control ...
To systematically review and meta-analyze evidence of nonpharmacological interventions for postoperative pain management after ... Of 5509 studies, 39 randomized clinical trials were included in the meta-analysis (2391 patients). The most commonly performed ... CONCLUSIONS AND RELEVANCE In this meta-analysis, electrotherapy and acupuncture after total knee arthroplasty were associated ... Interventions to Reduce Pain or Opioid Consumption After Total Knee Arthroplasty A Systematic Review and Meta-analysis ...
No results found! No results found for that in WHO HQ Library catalog. ...
Study Type : Meta Analysis. Additional Links Substances : Beta-glucan : CK(259) : AC(45), Fiber : CK(898) : AC(117), Oats : CK( ... DESIGN: A meta-analysis was performed on 28 RCTs comparing≥3 g OBG/d with an appropriate control. Systematic searches were ... Cholesterol-lowering effects of oatβ-glucan: a meta-analysis of randomized controlled trials. ... cholesterol from baseline between the OBG and control diets were analyzed by using random-effects meta-analysis models and meta ...
This meta-analysis showed that the administration of garlic resulted in a significant reduction in fasting blood glucose ... Our pooled analyses did not include PPG control and HbA1c outcomes. Because only 1 study included in the meta-analysis reported ... This meta-analysis showed that the administration of garlic resulted in a significant reduction in fasting blood glucose ... In conclusion, the current meta-analysis showed that the administration of garlic resulted in a significant reduction in FBG ...
... of randomized controlled trials. ... DATA SYNTHESIS: All pooled analyses were based on random-effects models. Five RCTs for hip fracture (n = 9294) and 7 RCTs for ... Topic Research Discovery. *Diseases. *Therapeutic Substances. *Therapeutic Actions. *Pharmacological Actions. *Problem ...
EBM Special Topic. Developing, Conducting, and Publishing Appropriate Systematic Review and Meta-Analysis Articles. Kelley, ... Preoperative Analysis/Marking. Video 1 from Gluteal Augmentation and Enhancement of the Female Silhouette -Analysis and ... Gluteal Augmentation and Enhancement of the Female Silhouette: Analysis and Technique. Mendieta, Constantino; Stuzin, James M. ... The Lateral Thigh Perforator Flap for Autologous Breast Reconstruction: A Prospective Analysis of 138 Flaps. Tuinder, Stefania ...
Meta-analysis findings. Individual study estimates reporting ITT analysis, overall pooled estimate and measures of ... One additional study by Petersen et al22 has been published on this topic since the 2010 Cochrane Review.36 This study differed ... Commentary: heterogeneity in meta-analysis should be expected and appropriately quantified. Int J Epidemiol 2008;37:1158-60. ... Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Int J Surg 2010;8:336-41. ...
What is already known on this topic. *. A number of meta-analyses have demonstrated that low-load blood flow restriction (BFR) ... 47 All meta-analyses were conducted with the Comprehensive Meta-Analysis software V.2.2.064 (Biostat, Englewood, New Jersey, ... Meta-analysis. Data analysis was performed by one author (LH) and reviewed by a statistician (CG). Data were extracted in the ... Meta-analysis. There is a growing interest in the use of LL-BFR training as a clinical MSK rehabilitation tool; however, the ...
How safe is PrEP? Meta-analysis finds no increased risk of serious side-effects A meta-analysis of randomised controlled trials ... according to the results of a meta-analysis published in the Journal of Virus Eradication. It was only when used in an ... ... Topics * Testing and health monitoring Types of HIV tests , HIV testing policies and guidelines , Taking an HIV test , HIV ... A new analysis also found a correlation between higher adherence to the daily drug regimen and greater bone density loss. ...
Overall meta-analyses quality was evaluated using a Spearmen regression analysis and found to positively correlate with time ( ... we evaluate the quality of meta-analyses published in 5 leading anesthesiology journals from 2005 to 2014. A total of 220 meta- ... Meta-analysis, when preceded by a systematic review, is considered the "gold standard" in data aggregation; however, the ... The quality of each meta-analysis was determined using the Revised Assessment of Multiple Systematic Reviews (R-AMSTAR). R- ...
Meta-analysis showed the odds of adults meeting minimum recommended PA levels were doubled in groups provided a PLPA ... Meta-analyses were conducted separately for interventions measuring the following: (1) participants meeting recommended PA ... Nonstatistical analysis identified that PLPA interventions were efficacious at increasing the amount of PA adults performed at ... Pooled effects were calculated using a fixed-effects model as standardized mean differences (SMDs). Nonstatistical analysis was ...
Thus, we conducted a meta-analysis to investigate the association between different dietary protein sources and breast cancer ... Topic. Search Strategy. Breast Cancer. "Breast Neoplasms" OR "Breast Cancer". Study. "Cohort" OR "Nested Case-control" OR "Case ... This meta-analysis was conducted in adherence to the Preferred Reporting Items for Systematic Review and Meta-analysis ... Subgroup and Sensitivity Analysis. Subgroup analysis and meta-regression were conducted for both highest versus lowest analysis ...
This systematic review and meta-analysis was undertaken to determine the survival rates and assess potential... ... Topic Review. First Online: 05 July 2017. Received: 08 February 2017. Accepted: 27 June 2017. ... Meta-analysis was undertaken using a binomial random effects model. Sixty-five studies (2336 participants) were included. Meta- ... Meta-analysis of 2 year overall survival was 15.3% (95% confidence interval 12-20%, I-sq 71.3%) based on 40 data sets (1329 ...
What is known on this topic?. Obesity is a primary risk factor for cardiovascular disease (CVD) and cardiometabolic disease ( ... Meta-regression. The results of the random-effects meta-regression analysis indicated that year of study (coefficient = −0.03; ... Results of the meta-analysis. We created forest plots of AUC scores based on BMI, WC, and WHR for CVD and CMD risk in men and ... This meta-analysis included 38 cross-sectional and 2 cohort studies with 105 to 137,256 participants aged 18 or older. The ...
... meta-analyses) on the use of PET for different clinical indications. It will provide evidence-based information on PET which ... Topics. *Nuclear Medicine. *immediately available upon purchase as print book shipments may be delayed due to the COVID-19 ... Summary of Recent Meta-analyses on PET. Editors: Treglia, Giorgio, Giovanella, Luca (Eds.) ... It is divided into five main sections, starting with an introduction to PET and meta-analysis. In turn, the second part ...
... for quantitative researchers and students in the medical and social sciences who wish to learn how to perform meta-analysis ... This book provides a comprehensive introduction to performing meta-analysis using the statistical software R. It is intended ... Includes chapters on the following advanced topics: publication bias and small study effects; missing data; multivariate meta- ... particularly meta-analysis. Her principal interests are small-study effects and heterogeneity in meta-analysis, meta-analysis ...
The objective of this meta-analysis was to quantitatively synthesize the results of CDSMP studies conducted in English-speaking ... we conducted 1 meta-analysis on this delivery mode and a separate meta-analysis on results by other delivery modes. In studies ... This meta-analysis had several limitations. First, the unit of analysis was the study, not the individual. Factors such as ... All analyses used Comprehensive Meta-Analysis version 2 (Biostat, Englewood, New Jersey) (13). Using the convention established ...
Determining an Effective Intervention Within a Brief Experimental Analysis for Reading: A Meta-Analytic Review ... The current study applied meta-analytic procedures to brief experimental analysis research of reading fluency interventions to ... Special Topic: Promoting Academic Competence for Underserved Students Volume 37, Issue 1 (2008 ). Editor: Thomas J. Power ... Using discriminant function analyses at four times, results suggest that in the fall of fourth grade several distinctions ...
Our meta-analysis aims to answer the question whether PTNB strategy increases the risk of recurrence. PubMed, EMBASE, The ... Subgroup analysis showed that PTNB was associated with increased pleural recurrence (Odds Ratio, 10.76; 95% CI, 2.92 to 39.70) ... this is the first meta-analysis focusing on this topic.. It is noteworthy that, despite the pooled analysis showed no ... This meta-analysis was performed according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) ...
The growing trend of network meta-analyses topic appearance in medical literature. ... The growing trend of network meta-analyses topic appearance in medical literature ... In this context, adjusted indirect comparisons based on network meta-analyses (NMAs) could answer the question posed by most ... Figure 1. Yearly trend in NMA publication topic in medical electronic databases.jpg ...
  • 3 4 Network meta-analyses of randomised controlled trials of NSAIDs and myocardial infarction risk have attempted to improve statistical power, but the results of direct and indirect comparisons of NSAIDs and placebo remain imprecise and occasionally inconclusive. (bmj.com)
  • A Systematic Review and Network Meta-analysis of 22 Randomized Controlled Trials. (bioportfolio.com)
  • Effects of Zinc Supplementation on Cardiometabolic Risk Factors: a Systematic Review and Meta-analysis of Randomized Controlled Trials. (bioportfolio.com)
  • Given the number of recently published randomized controlled trials (RCTs), it is important to update the findings of previous meta-analyses. (greenmedinfo.com)
  • Garlic intake lowers fasting blood glucose: meta-analysis of randomized controlled trials. (greenmedinfo.com)
  • Previous meta-analyses of chronic disease self-management programs suggest they offer modest health benefits (10-12), but these analyses combined multiple types of self-management programs, focused exclusively on randomized controlled trials (RCTs), and examined a limited range of outcomes. (cdc.gov)
  • Randomized controlled trials on the efficacy of structured versus abrupt withdrawal of desmopressin in sustaining relapse-free status in pediatric enuresis were included for meta-analysis. (aappublications.org)
  • Four randomized controlled trials (total 500 subjects) of adequate methodological quality were included for meta-analysis. (aappublications.org)
  • To address the uncertainties, the investigators propose to conduct a series of systematic reviews and meta-analyses of the totality of the evidence from randomized controlled trials and prospective cohort studies to investigate the effect of nut consumption on body weight and adiposity. (clinicaltrials.gov)
  • 2014]. Although an earlier systematic review and meta-analysis of controlled trials showed a lack of effect of nut intake on body weight [Flores-Mateo et al. (clinicaltrials.gov)
  • High quality systematic reviews and meta-analyses of randomized controlled trials and prospective cohort studies represent the highest level of evidence to support dietary guidelines and public health policy development. (clinicaltrials.gov)
  • Meta-analysis and randomized controlled trials provide a large data base of evidence towards improvement and opportunities, but it is suggested that case reports can still provide valuable clinical information. (biomedsearch.com)
  • Furthermore, the study supports that evidence from randomised controlled trials (RCTs) does not clearly support the intended benefits of nonnutritive sweeteners for weight management, however, in interpreting the pooled analyses of RCTs, the authors failed to account for the nature of the comparator, as highlighted in a published response to this publication. (sweeteners.org)
  • A total of 65 RCTs were eligible for inclusion (20 from the update and 45 from the original SR). The meta-analysis results demonstrate that all active interventions were associated with a statistically significant reduction (improvement) in OFF time (hours/day), UPDRS II, and UPDRS III scores compared with placebo. (ispor.org)
  • A meta-analysis was performed on 28 RCTs comparing≥3 g OBG/d with an appropriate control. (greenmedinfo.com)
  • The search will be limited to meta-analyses and RCTs. (clinicaltrials.gov)
  • Because of this exponential growth in publication rates, many meta-analysis authors may not discuss the results of previous meta-analyses and systematic reviews on the same topic - in a manner analogous to authors of RCTs not referring to a substantial portion of other relevant RCTs [ 3 ] or systematic reviews [ 4 , 5 ]. (biomedcentral.com)
  • Importantly, the selection criteria used for the meta-analysis of RCTs in this study led to the exclusion of several well-designed clinical trials that were included in previous thorough systematic reviews and meta-analyses. (sweeteners.org)
  • Common considerations in network meta-analysis include conceptual and statistical heterogeneity and incoherence. (bioportfolio.com)
  • Her principal interests are small-study effects and heterogeneity in meta-analysis, meta-analysis of diagnostic accuracy studies and application of graph theory in network meta-analysis. (springer.com)
  • The current meta-analysis emphasized the heterogeneity of modifiable risk factors of [Alzheimer's disease] and the complexity of its etiology, and indicated that the effective interventions in diet, medications, biochemical exposures, psychological condition, pre-existing disease and lifestyle may be promising options for preventative strategies. (healio.com)
  • Summary effect estimates were calculated by a random-effect model, and tests for multivariable-unadjusted pooled risk ratios (RR) and heterogeneity, as well as the sensitivity analyses were conducted to assess publication bias. (scielo.br)
  • In the cumulative dose and duration analyses, highest effect was observed in the highest/longest exposure group, but substantial heterogeneity was present. (springer.com)
  • To identify characteristics that significantly contributed to heterogeneity, we used meta-regression analysis. (psu.edu)
  • Meta-regression analysis identified that the most important factor contributing to heterogeneity among results for invasive lesions was departures from Hardy-Weinberg equilibrium in the control group. (psu.edu)
  • We performed subgroup analysis and metaregression analysis to examine potential sources of heterogeneity. (hindawi.com)
  • Subgroup and metaregression analyses indicated that the OCT type was the main source of heterogeneity. (hindawi.com)
  • Operative Versus Nonoperative Outcomes of Middle-Third Clavicle Fractures: A Systematic Review and Meta-Analysis. (bioportfolio.com)
  • Our pooled analyses did not include PPG control and HbA1c outcomes. (greenmedinfo.com)
  • Subgroup analysis comparing date of study, classification of tumor, use of temozolomide, non-standard interventions or phase 1/2 versus other studies demonstrated no difference in survival outcomes. (springer.com)
  • Decisions about studies to be included, statistical analyses, and moderating factors are made after the analysts know the outcomes of the studies. (frontiersin.org)
  • Although it was not studied in the meta-analysis, Feldman noted that new-onset A-fib is a potential periprocedural complication that can have a critical impact on later outcomes after AVR. (tctmd.com)
  • A meta-analysis was performed on studies that measured comparable outcomes. (jmir.org)
  • Review methods Eligible studies were sourced from computerised drug prescription or medical databases, conducted in the general or an elderly population, documented acute myocardial infarction as specific outcome, studied selective cyclo-oxygenase-2 inhibitors (including rofecoxib) and traditional NSAIDs, compared risk of acute myocardial infarction in NSAID users with non-users, allowed for time dependent analyses, and minimised effects of confounding and misclassification bias. (bmj.com)
  • Meta-analysis of metabolic ward studies of solid food diets in healthy volunteers. (bmj.com)
  • We update the TMSDG analysis by including studies omitted from that analysis and extracting additional data from included studies, such as deriving standard errors from p-values when the standard errors are not reported in the original article. (nber.org)
  • We find that the TMSDG analysis is underpowered: it would conclude that MDA has no effect even if the true effect were (1) large enough to be cost-effective relative to other interventions in similar populations, or (2) of a size that is consistent with results from studies of children known to be infected. (nber.org)
  • The studies had to assess mortality in women (22 cohorts) or men (17 cohorts) aged 50 years or older with hip fracture, carry out a life-table analysis, and display the survival curves of the hip fracture group and age- and sex-matched control groups. (annals.org)
  • Of 5509 studies, 39 randomized clinical trials were included in the meta-analysis (2391 patients). (stanford.edu)
  • Because only 1 study included in the meta-analysis reported PPG variables and only 2 studies reported HbA1c variables. (greenmedinfo.com)
  • Future studies should harmonize outcome and prognostic variable reporting to enable accurate meta-analysis and better exploration of prognosis. (springer.com)
  • This meta-analysis included 38 cross-sectional and 2 cohort studies with 105 to 137,256 participants aged 18 or older. (cdc.gov)
  • and meta-analysis of diagnostic studies. (springer.com)
  • The objective of this meta-analysis was to quantitatively synthesize the results of CDSMP studies conducted in English-speaking countries to determine the program's effects on health behaviors, physical and psychological health status, and health care utilization at 4 to 6 months and 9 to 12 months after baseline. (cdc.gov)
  • we conducted 1 meta-analysis on these studies and a separate analysis on results by other delivery modes. (cdc.gov)
  • Meta-analyses aim to provide a full and comprehensive summary of related studies which have addressed a similar question. (nih.gov)
  • We performed a meta-analysis of inception cohort studies. (cmaj.ca)
  • 1 They reported a meta-analysis of crude estimates and relative risk of death derived from nine published studies for Staphylococcus aureus bacteraemia. (mja.com.au)
  • Systematic review and meta-analysis of observational studies published between 1966 and June 2004 that examined the association between breast feeding and the development of CD. (bmj.com)
  • We undertook a systematic review and meta-analysis of longitudinal studies that reported the association between paracetamol exposure during pregnancy or infancy and the subsequent development of childhood asthma (≥5 years). (bmj.com)
  • Systematic review and meta-analysis of 15 studies of home visiting. (pubmedcentralcanada.ca)
  • Each meta-analysis doesn't just add studies up. (plos.org)
  • The small number of studies included in meta-analysis represents a major limitation. (aappublications.org)
  • The present paper points out that the principles of preregistered, well-powered confirmatory research apply for meta-analyses as well as for individual studies. (frontiersin.org)
  • To provide confirmatory evidence, the methodological decisions in a meta-analysis must be made prospectively, before the results of the included studies are known and ideally before the studies have been conducted. (frontiersin.org)
  • The most obvious option is to preregister the meta-analysis plan and include in the meta-analysis only studies conducted after the plan was registered. (frontiersin.org)
  • The meta-analysis plan would specify the statistical analyses and the criteria for deciding which studies are included. (frontiersin.org)
  • Subsequent studies that comply with the inclusion/exclusion criteria would be included in the meta-analysis. (frontiersin.org)
  • A total of 26 studies with cycling as the exercise modality were included in the meta-analysis. (frontiersin.org)
  • Combining data from similar studies (meta-analysis) can help to provide more reliable estimates of treatment effects. (jameslindlibrary.org)
  • Characteristics of the studies included in the meta-analysis. (elsevier.es)
  • In a meta-analysis of 323 studies, researchers identified medical, dietary, biochemical, psychological and lifestyle factors associated with increased and decreased risk for Alzheimer's disease. (healio.com)
  • Therefore, we have carried out the most extensive and comprehensive systematic review and meta-analysis to date, which employs a full-scale search of observational studies to calculate effect sizes of various modifiable risk factors for [Alzheimer's disease]," researchers from Qingdao University in Qingdao, China, wrote. (healio.com)
  • Four studies involving 595.776 participants, mean age range from 60 to 73.2 years old, were included in a meta-analysis, which produced a summary unadjusted RR of the risk of MBC for the treatment of 5ARIs of 1.16 (95% CI 0.85-1.58, P=0.36) and the multivariable-adjusted RR is 1.03, (95% CI 0.75-1.41, p=0.86). (scielo.br)
  • This meta-analysis was based on a systematic review of peer-reviewed observational studies published prior to September 30, 2016. (springer.com)
  • References from included studies and from previous meta-analyses were screened for additional records. (springer.com)
  • Of 363 identified records, 23 studies were included in this review and 18 in the actual meta-analyses. (springer.com)
  • In the sensitivity analysis, only studies adjusted for lifestyle-related factors were included and the frequentist effect size was 1.18 (95% CI, 1.00-1.40, p = 0.054). (springer.com)
  • Information on specific methodological features of studies addressing this topic published between 1998 and 2002 were obtained. (psu.edu)
  • Charat Thongprayoon, MD, from Bassett Medical Center, and his colleagues conducted an analysis of published studies that reported the risk of chronic kidney disease or kidney failure among proton pump inhibitor users compared with non-users. (healio.com)
  • Five studies with 536,902 participants met the eligibility criteria and were included in the meta-analysis. (healio.com)
  • The mathematical representation of Brunswik's lens model has been used extensively to study human judgment and provides a unique opportunity to conduct a meta-analysis of studies that covers roughly five decades. (ssrn.com)
  • An analysis of learning studies reveals that the most effective form of feedback is information about the task. (ssrn.com)
  • Karelaia, Natalia and Hogarth, Robin M., Determinants of Linear Judgment: A Meta-Analysis of Lens Model Studies (February 2007). (ssrn.com)
  • Findings: The meta-analysis included 29 studies representing 2,090 individuals. (ssrn.com)
  • Studies address a variety of topics including alternative welfare-to-work strategies, career pathways and post-secondary training models, employment retention and advancement approaches, subsidized employment and job search strategies, and tests to understand the effects of employment coaching models. (hhs.gov)
  • This will be done by comparing prediction performance based on meta-analytically derived networks and as well as networks from large individual studies. (fz-juelich.de)
  • The meta-analysis, published online February 1, 2018, ahead of print in Catheterization and Cardiovascular Interventions , included six studies published between 2012 and 2017 that enrolled a total of 3,484 patients. (tctmd.com)
  • According to the results of this meta-analysis, new studies could be planned to state the role of SPPB as a marker for tailoring the best management for elderly patients with cardiovascular disorders needing invasive procedure. (biomedcentral.com)
  • Use of meta-analysis in cross-national studies / Edith D. de Leeuw and Joop J. Hox. (worldcat.org)
  • A meta-analysis was carried out of studies that evaluate the effectiveness of mass media campaigns to influence drug use, intention to use, or the attitude towards illicit drugs of young people under the age of 26. (europa.eu)
  • The results of the analysis of the nine randomised controlled studies are presented below. (europa.eu)
  • Use of these methods should improve the efficiency and reliability of meta-analyses of the published literature with survival-type endpoints. (nih.gov)
  • The topics of debate have included the analysts' decisions about outcome measures, statistical methods, moderating variables, and inclusion/exclusion criteria for a meta-analysis. (frontiersin.org)
  • With meta-analysis methods playing a crucial role in health research in recent years, this important and clearly-written book provides a much-needed survey of the field. (wiley.com)
  • Medical researchers will grasp the basic principles of meta-analysis, and learn how to apply the various methods. (wiley.com)
  • Dr. Sutton is co-author of a textbook on metaanalysis (Methods for Meta Analysis in Medical Research), which was published by Wiley in 2000. (wiley.com)
  • Design Systematic review followed by a one stage bayesian individual patient data meta-analysis. (bmj.com)
  • Several sensitivity analyses including hierarchical Bayesian meta-analysis with country-specific effects were conducted. (springer.com)
  • Just last week, a new Bayesian analysis took a look at the EXCEL mortality question. (tctmd.com)
  • CONCLUSIONS AND RELEVANCE In this meta-analysis, electrotherapy and acupuncture after total knee arthroplasty were associated with reduced and delayed opioid consumption. (stanford.edu)
  • Conclusions: Although the relevance of our search strategy was not validated, this study showed a growing report of NMA topics in medical literature, probably reflecting the absence of head-to-head comparisons to identify the best interventions for specific conditions. (cochrane.org)
  • A bad or patchy meta-analysis might not come to as reliable conclusions as a well-conducted, adequately powered single study. (plos.org)
  • The investigators will review and perform meta-analyses of vitamin and mineral supplementation trials in relation to cardiovascular disease. (clinicaltrials.gov)
  • There was insufficient data to undertake subgroup meta-analysis of patient age, duration of symptoms, K27M histone mutations and AVCR1 mutations. (springer.com)
  • This open access book summarizes the findings of recent evidence-based articles (meta-analyses) on the use of positron emission tomography (PET) for various clinical indications. (springer.com)
  • In a series of earlier systematic reviews and meta-analyses, we have shown that nuts improve glycemic control and metabolic syndrome criteria, findings which run contrary to any expected weight gain. (clinicaltrials.gov)
  • Those wishing to challenge the findings of a retrospective meta-analysis easily find methodological decisions to debate. (frontiersin.org)
  • Meta-analyses on pharmacological treatments do not consistently refer to and discuss findings of previous meta-analyses on the same topic. (biomedcentral.com)
  • We reviewed the accumulated evidence and updated findings from previous meta-analyses. (springer.com)
  • Meta-analysis of randomized trials in which estimates of comparative treatment effects are visualized and interpreted from a network of interventions that may or may not have been evaluated directly against each other. (bioportfolio.com)
  • To systematically review and meta-analyze evidence of nonpharmacological interventions for postoperative pain management after total knee arthroplasty. (stanford.edu)
  • Nonstatistical analysis was used to identify the effect of PLPA interventions on the volume of PA performed at different intensities. (ovid.com)
  • Nonstatistical analysis identified that PLPA interventions were efficacious at increasing the amount of PA adults performed at all intensities. (ovid.com)
  • This systematic review and meta-analysis was undertaken to determine the survival rates and assess potential prognostic factors including selected interventions. (springer.com)
  • In this context, adjusted indirect comparisons based on network meta-analyses (NMAs) could answer the question posed by most healthcare professionals: what is the best intervention among the existing interventions for a specific condition? (cochrane.org)
  • We conducted a systematic review and meta-analysis to determine the effect of school-based physical activity interventions on body mass index (BMI) in children. (cmaj.ca)
  • Meta-analysis showed that BMI did not improve with physical activity interventions (weighted mean difference -0.05 kg/m 2 , 95% confidence interval -0.19 to 0.10). (cmaj.ca)
  • We reviewed 19 randomized clinical trials of parent-mediated interventions for children with autism spectrum disorder between the ages of 1 and 6 years and conducted a meta-analysis on their efficacy. (autismsciencefoundation.org)
  • Results were reported both descriptively for each study and using random effects meta-analysis. (nih.gov)
  • The meta-analysis results were consistent when conducted at the individual intervention level or drug class level and when conducted regardless of study follow-up (4 weeks to 9 months) and when restricting the data to 8-16 weeks follow-up. (ispor.org)
  • however, the quality of meta-analyses is often questionable, leading to uncertainty about the accuracy of results. (ovid.com)
  • Meta-analyses of median overall survival results was not possible due to the lack of reported measures of variance. (springer.com)
  • Using discriminant function analyses at four times, results suggest that in the fall of fourth grade several distinctions existed between students in regular and bilingual classrooms.By the spring of fifth grade, the number of differences diminished to just two variables among the groups. (nasponline.org)
  • But while combined results can carry a lot of weight, there are 3 main problems with the idea that a meta-analysis always trumps a single study. (plos.org)
  • A study by Paul Glasziou and colleagues in 2010 found that even when there were several trials, the most precise one carried on average half the weight of the results - and around 80% of the time the conclusion of the meta-analysis was pretty much the same as that single study. (plos.org)
  • The third problem is so big, it gets the next place on this listicle: a single new study can overturn the results of a meta-analysis. (plos.org)
  • As soon as the results of HF-ACTION were available, it was, on its own, a more reliable source on many questions than previous meta-analyses. (plos.org)
  • A PMA is one where trials are identified for inclusion in the analysis before any of the individual results are known. (clinicaltrials.gov)
  • The trials are sufficiently similar with respect to design, participants and intervention and, with planning, will have enough common outcome measures to enable their results to be prospectively meta-analysed. (clinicaltrials.gov)
  • Systematic reviews and meta-analyses represent a high level of evidence and are invaluable to health professionals in synthesizing the results of medical research [ 1 ]. (biomedcentral.com)
  • They find two similar meta-analyses with discordant results. (biomedcentral.com)
  • Results changed minimally in multiple sensitivity analyses, and there was no statistical support for the use of a nonlinear model. (stopumts.nl)
  • However, research on this topic has produced controversial results. (psu.edu)
  • Witberg said the conclusion of the meta-analysis could potentially be changed by the trials, adding, " I, as well as the whole of the interventional cardiology community, am eagerly awaiting their results within the next 18 months. (tctmd.com)
  • Meta-analysis provides a framework for combining the results of several clinical trials and drawing inferences about the effectiveness of medical treatments. (wiley.com)
  • Random-effects models were used for both main effects and a sensitivity analysis. (bmj.com)
  • His principal interests are coping with missing data in complex hierarchical models, sensitivity analysis and meta-analysis, with applications to medical and social data. (springer.com)
  • It all started with a Cochrane systematic review/meta-analysis in May that concluded the vaccine was, essentially, effective and safe for women ( Arbyn 2018 ). (plos.org)
  • In July, a scathing critique was published by a group of meta-analysts, under the banner of the Nordic Cochrane Centre in Copenhagen ( Jørgensen 2018 ). (plos.org)
  • A meta-analysis and systematic review of clinical randomized trials. (bioportfolio.com)
  • In addition to key topics such as bioethics, clinical outcome data, cultural diversity, protocol guidelines, and "omic platforms, this edition contains new chapters devoted to electronic health records and information resources for clinical researchers, as well as the many opportunities associated with big data. (barnesandnoble.com)
  • Covering a vast number of topics and practical advice for both novice and advanced clinical investigators, this book is a highly relevant and essential resource for all those involved in conducting research. (barnesandnoble.com)
  • Meta-analysis of Clinical Trials 26. (barnesandnoble.com)
  • As a substitute, we get a meta-analysis of randomized, clinical trials. (science20.com)
  • To provide patients, clinicians, and policymakers with the most useful information about a clinical question, meta-analyses should not neglect previous systematic reviews about the same topic. (biomedcentral.com)
  • We aimed to address this limitation in a systematic review and meta-analysis and to examine the clinical, biochemical and radiological risk factors in a meta-regression. (ssrn.com)
  • Our meta-analysis showed that a SPPB value below 10 predicts all-cause mortality in different clinical settings, geographical areas, and independently by age and follow-up lengths. (biomedcentral.com)
  • They did note whether trials were carried out under good clinical practice, whether an intention-to-treat (ITT) analysis had been performed, and if analysis had been per protocol. (york.ac.uk)
  • A Cochrane systematic review and meta-analyses by Hart et al. (springer.com)
  • He is an established researcher in the area of meta-analysis and lead statistician of several Cochrane reviews. (springer.com)
  • 14 Meta-analysis and risk of bias assessment were performed according to the Cochrane Collaboration recommendations. (aappublications.org)
  • Under-powered meta-analyses (such as TMSDG) are common in health research, and this methodological issue will be increasingly important as growing numbers of economists and other social scientists conduct meta-analysis. (nber.org)
  • Typical retrospective meta-analyses resemble exploratory rather than confirmatory research. (frontiersin.org)
  • Darbandi M, Pasdar Y, Moradi S, Mohamed HJJ, Hamzeh B, Salimi Y. Discriminatory Capacity of Anthropometric Indices for Cardiovascular Disease in Adults: A Systematic Review and Meta-Analysis. (cdc.gov)
  • We conducted a systematic review and meta-analysis to determine the effectiveness of these 3 indices to accurately predict CVD risk in adults and found that WC and WHR better predicted CVD risk than did BMI. (cdc.gov)
  • Firstly, a systematic review and meta-analysis isn't a formal experimental study. (plos.org)
  • To provide a systematic review and meta-regression analysis of recent trends in sperm counts as measured by sperm concentration (SC) and total sperm count (TSC), and their modification by fertility and geographic group. (stopumts.nl)
  • Prevalence, severity, and nature of preventable patient harm across medical care settings: systematic review and meta-analysis. (ahrq.gov)
  • Therefore, a systematic review and meta-analysis were carried out to evaluate choroidal changes in unilateral amblyopia. (hindawi.com)
  • After having published in chemical graph theory for a number of years, she started working in biostatistics, particularly meta-analysis. (springer.com)
  • Intermediate Topics in Biostatistics 23. (barnesandnoble.com)
  • A recent meta-analysis presented at ASN Kidney Week 2017 has linked certain medications commonly used to treat heartburn, acid reflux, and ulcers with the development of kidney disease. (healio.com)
  • A total of 220 meta-analyses published in Anesthesiology, Pain, British Journal of Anaesthesia, Anaesthesia, or Anesthesia & Analgesia were identified for inclusion. (ovid.com)
  • This is the type of retrospective decision that introduces bias in a meta-analysis-and makes retrospective specification of inclusion/exclusion criteria much easier than prospective specification. (frontiersin.org)
  • Only 14 of these met the criteria for inclusion in the meta-analysis. (europa.eu)
  • The primary objective of this meta-analysis was to determine the short-term (4-6 months) and longer-term (9-12 months) effect of the Stanford CDSMP. (cdc.gov)
  • Objective Analysis. (rand.org)
  • The RAND Drug Policy Research Center is a non-partisan research center dedicated to providing objective analysis and research to decisionmakers. (rand.org)
  • A new meta analysis in Menopause indicates that acupuncture can affect the severity and frequency of hot flashes for women in natural menopause. (science20.com)
  • Interpretation: Risk factors that emerged in our analyses predicting severity and case fatality should inform clinicians to define endophenotypes possessing a greater risk. (ssrn.com)
  • Potential moderating factors for the association between vascularization and graft failure and rejection were examined using metaregression analysis. (nih.gov)
  • The current study provides a comprehensive meta-analysis of adjuvant treatments of patients with PD. (ispor.org)
  • His special interests are in small-study effects in meta-analysis and statistical computing. (springer.com)
  • Random effects meta-regressions were performed to explore the predictive role of perinatal and demographic factors for between-study variance in effect sizes. (bmj.com)
  • Meta-analysis is combining and analyzing data from more than one study at a time. (plos.org)
  • 1. A meta-analysis is a safer starting point than a single study - but it won't necessarily be more reliable. (plos.org)
  • Secondly, it's not at all unusual for a meta-analysis to be heavily dominated by a single study. (plos.org)
  • Study-specific odds ratios (ORs) were combined in a meta-analysis, assuming random effects. (psu.edu)
  • The study relied on a statistical technique called meta-analysis. (envirolink.org)
  • This follow-up analysis of a phase 3 study provides further insights into the efficacy of valbenazine for tardive dyskinesia by extending the analysis to include odds ratios and number-needed-to-treat statistics. (psychiatrist.com)
  • The latest study to take a crack at the question of increased mortality according to revascularization choice in left main coronary artery disease-this one a meta-analysis looking at long-term data-has found no increased risk of mortality with PCI compared with CABG. (tctmd.com)
  • The aim of the current meta-analysis was to evaluate the comparative efficacy of agents used as adjuvant therapy in PD. (ispor.org)
  • Objectives: To evaluate the trend in NMAs publication topic in medical electronic databases and in the top five impact factor journals in the "Medicine, General and Internal" category. (cochrane.org)
  • Corneal neovascularization as a risk factor for graft failure and rejection after keratoplasty: an evidence-based meta-analysis. (nih.gov)
  • Thus, we conducted a meta-analysis to investigate the association between different dietary protein sources and breast cancer risk. (mdpi.com)
  • Our meta-analysis aims to answer the question whether PTNB strategy increases the risk of recurrence. (nature.com)
  • We therefore conducted this meta-analysis to assess whether PTNB strategy will increase the risk of pleural recurrence. (nature.com)
  • Meta-analysis showed that the risk of CD was significantly reduced in infants who were breast feeding at the time of gluten introduction (pooled odds ratio 0.48, 95% CI 0.40 to 0.59) compared with infants who were not breast feeding during this period. (bmj.com)
  • This meta-analysis provides insight in academic performance of the current population of preterm children and moderating effects of perinatal and demographic risk factors. (bmj.com)
  • Meta-regression analyses examined the moderator effects of potential risk factors. (ssrn.com)
  • On a positive note, the meta-analysis also found that the risk/benefit profile for periprocedural complications in low-risk patients is similar to that seen in the overall TAVR population, including less acute kidney injury and bleeding counterbalanced by an increase in pacemaker implantation and vascular complications. (tctmd.com)
  • Estimates of the mean reduction in serum cholesterol from baseline between the OBG and control diets were analyzed by using random-effects meta-analysis models and meta-regression. (greenmedinfo.com)
  • All pooled analyses were based on random-effects models. (greenmedinfo.com)
  • Meta-analysis was undertaken using a binomial random effects model. (springer.com)
  • Academic test scores and special educational needs of preterm and full-term children were analysed using random effects meta-analysis. (bmj.com)
  • Women experiencing natural menopause and aged between 40 and 60 years were included in the analysis, which evaluated the effects of various forms of acupuncture, including traditional Chinese medicine acupuncture (TCMA), acupressure, electroacupuncture, laser acupuncture and ear acupuncture. (science20.com)
  • Meta-analysis hazards ratios were derived using a random-effects model. (springer.com)
  • Random-effects meta-analyses were performed. (ssrn.com)
  • For the mean number of recurrent urinary tract infections, the pooled weighted mean difference (WMD) and corresponding 95% confidence intervals were calculated using both fixed-effect and random-effects meta-analysis. (york.ac.uk)
  • The evidence on this topic is controversial. (nature.com)
  • W]e have seldom seen a meta-analysis resolve a controversial debate in a field. (frontiersin.org)
  • To date, the topic of amblyopic changes remains controversial. (hindawi.com)
  • Drawing upon decades of experience, RAND provides research services, systematic analysis, and innovative thinking to a global clientele that includes government agencies, foundations, and private-sector firms. (rand.org)
  • Written by two leading drug advisors, the analysis contributes to an important field of research. (rand.org)
  • Primary, secondary and meta-analysis of research. (jameslindlibrary.org)
  • Not referring to important related research is also against the principles of evidence-based medicine, because meta-analysts agree that all available evidence should be systematically searched and reviewed in an unbiased manner [ 12 ]. (biomedcentral.com)
  • PDF] A meta-analysis of 25 years of mood-creativity research: hedonic tone, activation, or regulatory focus? (semanticscholar.org)
  • The article co-author with recognized expertise in meta-analysis, Ingram Olkin, applied for a grant from Council of Tobacco Research (CTR) in 1976. (envirolink.org)
  • and an introduction to meta-analysis in comparative survey research. (worldcat.org)
  • As the number of systematic reviews is growing rapidly, we systematically investigate whether meta-analyses published in leading medical journals present an outline of available evidence by referring to previous meta-analyses and systematic reviews. (biomedcentral.com)
  • Previous systematic reviews and meta-analyses were identified with electronic searches of keywords and by searching reference sections. (biomedcentral.com)
  • We identified 52 recent meta-analyses and 242 previous meta-analyses on the same topics. (biomedcentral.com)
  • Of these, 66% of identified previous meta-analyses were cited, 36% described, and only 20% discussed by recent meta-analyses. (biomedcentral.com)
  • If the question has been already answered in a previous meta-analysis, the authors should clearly justify why they decided to perform a similar analysis again. (biomedcentral.com)
  • We report a systematic investigation of whether recent meta-analyses published in the leading medical journals cite, describe, and discuss previous meta-analyses and systematic reviews on the same topic. (biomedcentral.com)
  • Previous meta-analyses on this topic utilized publications prior to 2013. (springer.com)
  • Meta-analysis showed 1 year overall survival (OS) of 41% (95% confidence interval (CI) 38-44%, I-sq 52%, 2083 participants), 2 year OS of 15.3% (95% confidence interval 12-20%, I-sq 73.1%, 1329 participants) and 3 year OS of 7.3% (95% confidence interval 5.2-10%, I-sq 26%, 584 participants). (springer.com)
  • BP meta-analysis summary statistics combined 757,601 participants from the United Kingdom Biobank (n = 458,577) and International Consortium of Blood Pressure GWASs (n = 299,024 across 77 cohorts). (ajmc.com)
  • We searched PubMed for recent meta-analyses of pharmacological treatments published in high impact factor journals. (biomedcentral.com)
  • For incidence of dysuria, leukocyturia and bacteriuria at final visit, the pooled odds ratio and corresponding 95% confidence intervals were calculated using an unspecified meta-analysis. (york.ac.uk)
  • Given the inconsistency among the current publications and insufficient statistical power of primary trials, we used a meta-analysis to examine the existing evidence obtained by EDI-OCT for detecting choroidal changes in unilateral amblyopia. (hindawi.com)
  • The move towards evidence-based health care and practice is underpinned by the use of meta-analysis. (wiley.com)
  • This analysis aims to contribute to the debate via a review of available evidence on the topic. (europa.eu)
  • Meta-analysis showed the odds of adults meeting minimum recommended PA levels were doubled in groups provided a PLPA intervention [OR = 2.15, 95% confidence interval (CI) = 1.35-3.43]. (ovid.com)
  • For the proportion of patients without recurrent urinary tract infections, the authors calculated the pooled odds ratio and corresponding 95% confidence intervals using an unspecified meta-analysis. (york.ac.uk)
  • The development of enhanced depth imaging optical coherence tomography (EDI-OCT) has allowed in vivo cross-sectional choroidal imaging and precise quantitative analysis of choroidal thickness (CT). (hindawi.com)
  • Incomplete or inconsistent reporting of outcome measures limited the data available for meta-analysis beyond 24 months. (aappublications.org)
  • The quality of each meta-analysis was determined using the Revised Assessment of Multiple Systematic Reviews (R-AMSTAR). (ovid.com)
  • The complete article "The impact of supplementary short rest breaks on task performance - A meta-analysis" can be downloaded at the website of the Journal "sozialpolitik.ch", Volume 2/2016, pp. 1-24 (charges may apply). (baua.de)
  • Published in BMC Medicine , a meta-analysis looks at whether a patient's SPPB score can be used a predictor for all cause mortality. (biomedcentral.com)
  • The value of these gold-standard trials can be further enhanced when, with careful planning, they are synthesised into a prospective meta-analysis (PMA). (clinicaltrials.gov)
  • We have established the Neonatal Oxygenation Prospective Meta-analysis (NeOProM) Collaboration, comprising the investigators of these five trials and a methodology team. (clinicaltrials.gov)
  • Three options for prospective meta-analysis are discussed below. (frontiersin.org)
  • This book provides a comprehensive introduction to performing meta-analysis using the statistical software R. It is intended for quantitative researchers and students in the medical and social sciences who wish to learn how to perform meta-analysis with R. As such, the book introduces the key concepts and models used in meta-analysis. (springer.com)
  • Using the most recent GWAS summary-level data from the International Headache Genetics Consortium for migraine, the researchers conducted a meta-analysis on 59,674 cases and 316,078 controls from 22 cohort-level GWASs. (ajmc.com)
  • The researchers also found 9 replicating single nucleotide polymorphisms (SNPs) from cross-trait association analysis, in addition to 12 genes from TWAS of both migraine and BP, which suggested potential functions relevant to migraine, the authors write. (ajmc.com)
  • 10 trials are available in a meta-analysis, publication bias analysis will not be assessed due to insufficient power. (clinicaltrials.gov)
  • Alex Sutton has published extensively on meta-analysis methodology generally, and on publication bias specifically in recent years, including a major systematic review on the topic of the methodology that has been developed for meta-analysis. (wiley.com)
  • Assumptions were examined using multiple sensitivity analyses and nonlinear models. (stopumts.nl)
  • It is divided into five main sections, starting with an introduction to PET and meta-analysis. (springer.com)
  • An Introduction to Survival Analysis 22. (barnesandnoble.com)