AnatomyDiseasesChemicals and DrugsHealth Care
MesotheliomaPleural NeoplasmsAsbestosPeritoneal NeoplasmsZeolitesAsbestosisAsbestos, CrocidoliteMesothelioma, CysticPleuraPleural Effusion, MalignantAsbestos, AmphiboleCalbindin 2Mineral FibersAsbestos, SerpentineNeoplasms, MesothelialEpithelioid CellsAsbestos, AmositeLung NeoplasmsOccupational ExposureOccupational DiseasesGPI-Linked ProteinsS100 Calcium Binding Protein GPleural EffusionGuanineGlutamatesTumor Markers, BiologicalPleural DiseasesPleurisyTesticular Hydrocele
Mesothelioma
A tumor derived from mesothelial tissue (peritoneum, pleura, pericardium). It appears as broad sheets of cells, with some regions containing spindle-shaped, sarcoma-like cells and other regions showing adenomatous patterns. Pleural mesotheliomas have been linked to exposure to asbestos. (Dorland, 27th ed)
Pleural Neoplasms
Neoplasms of the thin serous membrane that envelopes the lungs and lines the thoracic cavity. Pleural neoplasms are exceedingly rare and are usually not diagnosed until they are advanced because in the early stages they produce no symptoms.
Asbestos
Asbestos. Fibrous incombustible mineral composed of magnesium and calcium silicates with or without other elements. It is relatively inert chemically and used in thermal insulation and fireproofing. Inhalation of dust causes asbestosis and later lung and gastrointestinal neoplasms.
Peritoneal Neoplasms
Tumors or cancer of the PERITONEUM.
Zeolites
Zeolites. A group of crystalline, hydrated alkali-aluminum silicates. They occur naturally in sedimentary and volcanic rocks, altered basalts, ores, and clay deposits. Some 40 known zeolite minerals and a great number of synthetic zeolites are available commercially. (From Merck Index, 11th ed)
Asbestosis
A form of pneumoconiosis caused by inhalation of asbestos fibers which elicit potent inflammatory responses in the parenchyma of the lung. The disease is characterized by interstitial fibrosis of the lung, varying from scattered sites to extensive scarring of the alveolar interstitium.
Asbestos, Crocidolite
A lavender, acid-resistant asbestos.
Mesothelioma, Cystic
A peritoneal mesothelioma affecting mainly young females and producing cysts of variable size and number lined by a single layer of benign mesothelial cells. The disease follows a benign course and is compatible with a normal life expectancy, requiring occasionally partial excision or decompression for relief of pain or other symptoms. Malignant potential is exceptional. (From Holland et al., Cancer Medicine, 3d ed, p1345)
Pleura
The thin serous membrane enveloping the lungs (LUNG) and lining the THORACIC CAVITY. Pleura consist of two layers, the inner visceral pleura lying next to the pulmonary parenchyma and the outer parietal pleura. Between the two layers is the PLEURAL CAVITY which contains a thin film of liquid.
Pleural Effusion, Malignant
Presence of fluid in the PLEURAL CAVITY as a complication of malignant disease. Malignant pleural effusions often contain actual malignant cells.
Asbestos, Amphibole
A class of asbestos that includes silicates of magnesium, iron, calcium, and sodium. The fibers are generally brittle and cannot be spun, but are more resistant to chemicals and heat than ASBESTOS, SERPENTINE. (From Hawley's Condensed Chemical Dictionary, 11th ed)
Calbindin 2
A calbindin protein that is differentially expressed in distinct populations of NEURONS throughout the vertebrate and invertebrate NERVOUS SYSTEM, and modulates intrinsic neuronal excitability and influences LONG-TERM POTENTIATION. It is also found in LUNG, TESTIS, OVARY, KIDNEY, and BREAST, and is expressed in many tumor types found in these tissues. It is often used as an immunohistochemical marker for MESOTHELIOMA.
Mineral Fibers
Long, pliable, cohesive natural or manufactured filaments of various lengths. They form the structure of some minerals. The medical significance lies in their potential ability to cause various types of PNEUMOCONIOSIS (e.g., ASBESTOSIS) after occupational or environmental exposure. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p708)
Asbestos, Serpentine
A type of asbestos that occurs in nature as the dihydrate of magnesium silicate. It exists in two forms: antigorite, a plated variety, and chrysotile, a fibrous variety. The latter makes up 95% of all asbestos products. (From Merck Index, 11th ed, p.893)
Neoplasms, Mesothelial
Neoplasms composed of tissue of the mesothelium, the layer of flat cells, derived from the mesoderm, which lines the body cavity of the embryo. In the adult it forms the simple squamous epithelium which covers all true serous membranes (peritoneum, pericardium, pleura). The concept does not refer to neoplasms located in these organs. (From Dorland, 27th ed)
Epithelioid Cells
Characteristic cells of granulomatous hypersensitivity. They appear as large, flattened cells with increased endoplasmic reticulum. They are believed to be activated macrophages that have differentiated as a result of prolonged antigenic stimulation. Further differentiation or fusion of epithelioid cells is thought to produce multinucleated giant cells (GIANT CELLS).
Asbestos, Amosite
Asbestos, grunerite. A monoclinic amphibole form of asbestos having long fibers and a high iron content. It is used in insulation. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Lung Neoplasms
Tumors or cancer of the LUNG.
Occupational Exposure
The exposure to potentially harmful chemical, physical, or biological agents that occurs as a result of one's occupation.
Occupational Diseases
Diseases caused by factors involved in one's employment.
GPI-Linked Proteins
A subclass of lipid-linked proteins that contain a GLYCOSYLPHOSPHATIDYLINOSITOL LINKAGE which holds them to the CELL MEMBRANE.
S100 Calcium Binding Protein G
A calbindin protein found in many mammalian tissues, including the UTERUS, PLACENTA, BONE, PITUITARY GLAND, and KIDNEYS. In intestinal ENTEROCYTES it mediates intracellular calcium transport from apical to basolateral membranes via calcium binding at two EF-HAND MOTIFS. Expression is regulated in some tissues by VITAMIN D.
Pleural Effusion
Presence of fluid in the pleural cavity resulting from excessive transudation or exudation from the pleural surfaces. It is a sign of disease and not a diagnosis in itself.
Guanine
Glutamates
Derivatives of GLUTAMIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the 2-aminopentanedioic acid structure.
Tumor Markers, Biological
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
Pleural Diseases
Pleurisy
INFLAMMATION of PLEURA, the lining of the LUNG. When PARIETAL PLEURA is involved, there is pleuritic CHEST PAIN.
Testicular Hydrocele
Accumulation of serous fluid between the layers of membrane (tunica vaginalis) covering the TESTIS in the SCROTUM.

The European mesothelioma epidemic. (1/1637)

Projections for the period 1995-2029 suggest that the number of men dying from mesothelioma in Western Europe each year will almost double over the next 20 years, from 5000 in 1998 to about 9000 around 2018, and then decline, with a total of about a quarter of a million deaths over the next 35 years. The highest risk will be suffered by men born around 1945-50, of whom about 1 in 150 will die of mesothelioma. Asbestos use in Western Europe remained high until 1980, and substantial quantities are still used in several European countries. These projections are based on the fit of a simple age and birth cohort model to male pleural cancer mortality from 1970 to 1989 for six countries (Britain, France, Germany, Italy, The Netherlands and Switzerland) which together account for three-quarters of the population of Western Europe. The model was tested by comparing observed and predicted numbers of deaths for the period 1990-94. The ratio of mesothelioma to recorded pleural cancer mortality has been 1.6:1 in Britain but was assumed to be 1:1 in other countries.  (+info)

An expert system for the evaluation of historical asbestos exposure as diagnostic criterion in asbestos-related diseases. (2/1637)

Compensation schemes for asbestos-related diseases have developed different strategies for attributing a specific disease to occupational exposure to asbestos in the past. In the absence of quantitative exposure information that allows a valid estimate of an individual's historical exposure, general guidelines are required to retrospectively evaluate asbestos exposure. A risk matrix has been developed that contains qualitative information on the proportion of workers exposed and the level of exposure in particular industries over time. Based on this risk matrix, stepwise decision trees were formulated for decisions regarding the decisive role of historical asbestos exposure in case ascertainment of asbestosis and mesothelioma. Application of decision schemes will serve to speed up the process of verifying compensation claims and also contribute to a uniform decision-making process in legal procedures.  (+info)

A historical cohort mortality study of workers exposed to asbestos in a refitting shipyard. (3/1637)

To investigate the risks of developing asbestos-related diseases we conducted a historical cohort mortality study on 249 ship repair workers (90 laggers and 159 boiler repairers) in a single U.S. Navy shipyard in Japan. We successfully identified the vital status of 87 (96.7%) laggers and 150 (94.3%) boiler repairers, and, of these, 49 (56.3%) and 65 (43.3%) died, respectively, during the follow-up period from 1947 till the end of 1996. Our in-person interviews with some of the subjects clarified that asbestos exposure was considered to be substantially high in the 1950-60s, decreased thereafter gradually but remained till 1979 in the shipyard. The laggers, who had handled asbestos materials directly, showed a significantly elevated SMR of 2.75 (95% C.I.: 1.08-6.48) for lung cancer. The risk developing the disease was greater in the laggers after a 20-year latency (SMR = 3.42). Pancreatic cancer yielded a greater SMR than unity (7.78, 90% C.I.: 2.07-25.19) in a longer working years group. Four laggers died from asbestosis. The boiler repairers, who had many chances for secondary exposure to asbestos and a few for direct exposure, showed no elevation of the SMR of lung cancer overall, but there was a borderline statistically significant SMR of 2.41 (90% C.I.: 1.05-5.45) in a longer working years group. One boiler repairer died from mesothelioma and four from asbestosis.  (+info)

Morphological variations in transplanted tumors developed by inoculation of spontaneous mesothelioma cell lines derived from F344 rats. (4/1637)

Morphological and immunohistochemical features of the abdominal mesotheliomas that were developed by inoculation of 3 cell lines (MeET-4, -5 and -6) established from spontaneous abdominal mesotheliomas in male F344 rats. Although the original tumors of three cell lines showed signs of epithelioid growth with a predominantly simple papillary pattern, transplanted tumors revealed a variety of morphologic features including epithelioid with glandular structures, sarcomatous, and a mixture of these components. All tumor cells of transplanted tumors were positive for alpha-smooth muscle actin (ASMA) but almost negative for desmin as were epithelioid cells of the original tumors, and the cell lines were positive for desmin but not for ASMA. These results suggested that mesothelioma in the F344 rat had the potential for wide spectrum differentiation under in vitro conditions. The microenvironmental factors obtained in vivo can modify their potential ability and their morphological aspects. These factors may be related to tumor cell reexpression of ASMA of tumor cells that were masked under in vitro culture conditions.  (+info)

T-cell receptor transgenic analysis of tumor-specific CD8 and CD4 responses in the eradication of solid tumors. (5/1637)

The role of tumor-specific CD8 and CD4 lymphocytes in rejecting solid tumors has been difficult to determine because of the lack of models in which tumor antigen, specific CD8 cells, and specific CD4 cells can be monitored and controlled. To investigate the minimal components required for the induction and maintenance of CTL activity sufficient to reject a solid tumor in vivo, we transfected the influenza hemagglutinin (HA) gene into a nonimmunogenic class I+/class II- murine malignant mesothelioma (MM) tumor line to generate an endogenous tumor antigen and used TCR transgenic mice with class I- or class II-restricted specificities for HA as sources of naive, tumor-specific T cells. The data show that the presence of a strong tumor antigen is not in itself sufficient to induce an effective CTL response, nor does the presence of a high frequency of precursor cells guarantee tumor rejection. We also show that tumor-specific CD4 cells, when CTL numbers are suboptimal, greatly enhance the eradication of tumor, confirming the importance of antigen-presenting cell presentation of tumor antigens to class II-restricted cells. These data confirm that T-cell receptor transgenic cells, combined with nominal tumor antigen transfection, represent powerful tools to analyze tumor-specific T-cell responses.  (+info)

Photodynamic therapy with mTHPC and polyethylene glycol-derived mTHPC: a comparative study on human tumour xenografts. (6/1637)

The photosensitizing properties of m-tetrahydroxyphenylchlorin (mTHPC) and polyethylene glycol-derivatized mTHPC (pegylated mTHPC) were compared in nude mice bearing human malignant mesothelioma, squamous cell carcinoma and adenocarcinoma xenografts. Laser light (20 J/cm2) at 652 nm was delivered to the tumour (surface irradiance) and to an equal-sized area of the hind leg of the animals after i.p. administration of 0.1 mg/kg body weight mTHPC and an equimolar dose of pegylated mTHPC, respectively. The extent of tumour necrosis and normal tissue injury was assessed by histology. Both mTHPC and pegylated mTHPC catalyse photosensitized necrosis in mesothelioma xenografts at drug-light intervals of 1-4 days. The onset of action of pegylated mTHPC seemed slower but significantly exceeds that of mTHPC by days 3 and 4 with the greatest difference being noted at day 4. Pegylated mTHPC also induced significantly larger photonecrosis than mTHPC in squamous cell xenografts but not in adenocarcinoma at day 4, where mTHPC showed greatest activity. The degree of necrosis induced by pegylated mTHPC was the same for all three xenografts. mTHPC led to necrosis of skin and underlying muscle at a drug-light interval of 1 day but minor histological changes only at drug-light intervals from 2-4 days. In contrast, pegylated mTHPC did not result in histologically detectable changes in normal tissues under the same treatment conditions at any drug-light interval assessed. In this study, pegylated mTHPC had advantages as a photosensitizer compared to mTHPC. Tissue concentrations of mTHPC and pegylated mTHPC were measured by high-performance liquid chromatography in non-irradiated animals 4 days after administration. There was no significant difference in tumour uptake between the two sensitizers in mesothelioma, adenocarcinoma and squamous cell carcinoma xenografts. Tissue concentration measurements were of limited use for predicting photosensitization in this model.  (+info)

Multicentre randomised controlled trial of nursing intervention for breathlessness in patients with lung cancer. (7/1637)

OBJECTIVE: To evaluate the effectiveness of nursing intervention for breathlessness in patients with lung cancer. DESIGN: Patients diagnosed with lung cancer participated in a multicentre randomised controlled trial where they either attended a nursing clinic offering intervention for their breathlessness or received best supportive care. The intervention consisted of a range of strategies combining breathing control, activity pacing, relaxation techniques, and psychosocial support. Best supportive care involved receiving standard management and treatment available for breathlessness, and breathing assessments. Participants completed a range of self assessment questionnaires at baseline, 4 weeks, and 8 weeks. SETTING: Nursing clinics within 6 hospital settings in the United Kingdom. PARTICIPANTS: 119 patients diagnosed with small cell or non-small cell lung cancer or with mesothelioma who had completed first line treatment for their disease and reported breathlessness. OUTCOME MEASURES: Visual analogue scales measuring distress due to breathlessness, breathlessness at best and worst, WHO performance status scale, hospital anxiety and depression scale, and Rotterdam symptom checklist. RESULTS: The intervention group improved significantly at 8 weeks in 5 of the 11 items assessed: breathlessness at best, WHO performance status, levels of depression, and two Rotterdam symptom checklist measures (physical symptom distress and breathlessness) and showed slight improvement in 3 of the remaining 6 items. CONCLUSION: Most patients who completed the study had a poor prognosis, and breathlessness was typically a symptom of their deteriorating condition. Patients who attended nursing clinics and received the breathlessness intervention experienced improvements in breathlessness, performance status, and physical and emotional states relative to control patients.  (+info)

Telomerase activity in human pleural mesothelioma. (8/1637)

BACKGROUND: Gradual telomere erosion eventually limits the replicative life span of somatic cells and is regarded as an ultimate tumour suppressor mechanism, eliminating cells that have accumulated genetic alterations. Telomerase, which has been found in over 85% of human cancers, elongates telomeres and may be required for tumorigenesis by the process of immortalisation. Malignant mesothelioma is an incurable malignancy with a poor prognosis. The disease becomes symptomatic decades after exposure to carcinogenic asbestos fibres, suggesting the long term survival of pre-malignant cell clones. This study investigated the presence of telomerase in pleural malignant mesothelioma, which may be the target for future anti-telomerase drugs. METHODS: Telomerase activity was semiquantitatively measured in extracts from 22 primary pleural mesotheliomas, two benign solitary fibrous tumours of the pleura, four mesothelioma cell lines, and six short term mesothelial cell cultures from normal pleura using a non-isotopic dilution assay of the telomeric repeat amplification protocol. RESULTS: Twenty of the 22 primary mesotheliomas (91%) and all tumour derived mesothelioma cell lines were telomerase positive. Different levels of enzyme activity were observed in the tumours of different histological subtypes. Telomerase activity could not be detected in the six normal mesothelial cell cultures or in the two mesotheliomas. Both benign solitary fibrous tumours showed strong telomerase activity. CONCLUSIONS: Telomerase activity is found in a high proportion of mesotheliomas and anti-telomerase drugs might therefore be useful clinically. The results are consistent with the hypothesis that telomerase activity may be a feature of carcinogenesis in mesotheliomas and possibly in many other cancers.  (+info)

Mesothelioma is a rare form of cancer that develops in the lining of the heart or abdomen (abdominal cavity). It is caused by exposure to asbestos, which is a group of minerals found in old buildings and other products. There are three main types of mesothelioma: pleural (in the lining of the lungs), peritoneal (in the lining of the abdomen), and pericardial (in the lining of the heart).

The symptoms of mesothelioma can vary depending on the location of the cancer, but they may include:

* Shortness of breath or pain in the chest (for pleural mesothelioma)
* Abdominal pain or swelling (for peritoneal mesothelioma)
* Fatigue or fever (for pericardial mesothelioma)
* Weight loss and night sweats

There is no cure for mesothelioma, but treatment options may include surgery, chemotherapy, and radiation therapy. The prognosis for mesothelioma is generally poor, with a five-year survival rate of about 5% to 10%. However, the outlook can vary depending on the type of mesothelioma, the stage of the cancer, and the patient's overall health.

Asbestos exposure is the primary risk factor for developing mesothelioma, and it is important to avoid exposure to asbestos in any form. This can be done by avoiding old buildings and products that contain asbestos, wearing protective clothing and equipment when working with asbestos, and following proper safety protocols when handling asbestos-containing materials.

In summary, mesothelioma is a rare and aggressive form of cancer that develops in the lining of the heart or abdomen due to exposure to asbestos. It can be difficult to diagnose and treat, and the prognosis is generally poor. However, with proper medical care and avoidance of asbestos exposure, patients with mesothelioma may have a better chance of survival.

Pleural Neoplasms are abnormal growths or tumors that occur in the pleura, which is the thin membrane that lines the inside of the chest cavity and surrounds the lungs. These tumors can be benign (non-cancerous) or malignant (cancerous).

Benign pleural neoplasms include:

1. Pleomorphic adenoma: A rare, slow-growing tumor that usually occurs in the soft tissues of the chest wall.
2. Pneumoschisis: A condition where there is a tear or separation in the membrane that lines the lung, which can cause air to leak into the pleural space and create a benign tumor.
3. Pleural plaques: Calcified deposits that form in the pleura as a result of inflammation or injury.

Malignant pleural neoplasms include:

1. Mesothelioma: A rare and aggressive cancer that originates in the pleura, usually caused by exposure to asbestos.
2. Lung cancer: Cancer that spreads to the pleura from another part of the body, such as the lungs.
3. Metastatic tumors: Tumors that have spread to the pleura from another part of the body, such as the breast or colon.

Pleural neoplasms can cause a variety of symptoms, including chest pain, shortness of breath, coughing, and fatigue. Diagnosis is typically made through a combination of imaging tests, such as CT scans and PET scans, and a biopsy to confirm the presence of cancerous cells. Treatment options for pleural neoplasms depend on the type and stage of the tumor, and may include surgery, chemotherapy, and radiation therapy.

Peritoneal Neoplasms are a type of cancer that originates in the peritoneum, which is the thin layer of tissue that lines the inner abdominal cavity and covers the organs within. This type of cancer can arise from various types of cells, including epithelial cells, mesothelial cells, and immune cells.

Peritoneal neoplasms are relatively rare, but they can be aggressive and difficult to treat. The most common types of peritoneal neoplasms include:

1. Peritoneal mesothelioma: This is the most common type of peritoneal neoplasm and arises from the mesothelial cells that line the abdominal cavity. It is often associated with asbestos exposure.
2. Ovarian cancer: This type of cancer originates in the ovaries and can spread to the peritoneum.
3. Appendiceal cancer: This type of cancer arises in the appendix and can spread to the peritoneum.
4. Pseudomyxoma peritonei: This is a rare type of cancer that originates in the abdominal cavity and resembles a mucin-secreting tumor.
5. Primary peritoneal cancer: This type of cancer originates in the peritoneum itself and can be of various types, including adenocarcinoma, squamous cell carcinoma, and sarcoma.

The symptoms of peritoneal neoplasms vary depending on the location and size of the tumor, but may include abdominal pain, distension, and difficulty eating or passing stool. Treatment options for peritoneal neoplasms depend on the type and stage of the cancer, but may include surgery, chemotherapy, and radiation therapy. Prognosis for peritoneal neoplasms is generally poor, with a five-year survival rate of around 20-30%.

Asbestosis is a chronic lung disease caused by exposure to asbestos fibers. It is a type of interstitial lung disease, which means that the fibers cause inflammation and scarring in the lungs. The disease can progress over time and lead to shortness of breath, coughing, and permanent lung damage. Asbestosis is usually diagnosed through a combination of physical examination, medical history, and imaging tests such as chest X-rays or CT scans.

There are several types of asbestos, including chrysotile, amianthus, and crocidolite, each of which has different levels of toxicity. Prolonged exposure to any type of asbestos can cause asbestosis, but some types are more dangerous than others.

Symptoms of asbestosis may not appear until many years after exposure to asbestos, and they can vary in severity. Common symptoms include:

* Shortness of breath
* Coughing
* Permanent lung damage
* Scarring of the lungs
* Decreased lung function

Treatment for asbestosis usually involves managing symptoms and improving lung function. This can include medications to relieve coughing and shortness of breath, pulmonary rehabilitation to improve lung function, and oxygen therapy to help increase oxygen levels in the blood. In severe cases, lung transplantation may be necessary.

Prevention is key in avoiding asbestosis. If you suspect that you have been exposed to asbestos, it is important to speak with a healthcare professional as soon as possible. Proper safety measures and precautions can help minimize the risk of developing asbestosis.

Cystic Mesothelioma: A rare and aggressive form of cancer that affects the lining of the abdominal cavity (peritoneum). It is characterized by the presence of cysts in the affected tissue, which can be filled with fluid or semisolid material.

The term "cystic" refers to the presence of these fluid-filled sacs, which are typically found in the peritoneal lining of the abdomen. Cystic mesothelioma accounts for only about 5% of all mesothelioma cases and tends to affect younger people more frequently than other types of mesothelioma.

Cystic mesothelioma is often difficult to diagnose accurately, as the cysts can be confused with benign (non-cancerous) conditions such as ovarian cysts or abscesses. Surgery is the primary treatment for cystic mesothelioma, and it may involve the removal of affected organs or tissues. Chemotherapy and radiation therapy may also be used in combination with surgery to treat this rare and aggressive form of cancer.

Cystic mesothelioma is a rare subtype of malignant mesothelioma that accounts for approximately 5% of all cases. It is characterized by the presence of fluid-filled cysts in the peritoneal lining of the abdominal cavity. The cysts can be filled with a variety of substances, including serous fluid, hemorrhagic fluid, or semisolid material.

The exact cause of cystic mesothelioma is not known, but it is believed to be linked to exposure to asbestos, which can cause inflammation and scarring in the peritoneum. The disease typically affects younger people, with most cases occurring in those under the age of 50.

The symptoms of cystic mesothelioma can vary depending on the location and size of the cysts, but may include abdominal pain, nausea, vomiting, fever, and weight loss. Diagnosis is based on a combination of imaging tests, such as CT scans and PET scans, and a biopsy to confirm the presence of cancer cells.

Treatment for cystic mesothelioma is usually a combination of surgery and chemotherapy. The goal of surgery is to remove as much of the cancerous tissue as possible, while chemotherapy is used to kill any remaining cancer cells. In some cases, radiation therapy may also be recommended to help relieve symptoms such as pain or blockage of the intestine.

The prognosis for cystic mesothelioma is generally poor, with a five-year survival rate of less than 10%. However, the outlook can vary depending on factors such as the stage of the disease at the time of diagnosis and the effectiveness of treatment.

Overall, cystic mesothelioma is a rare and aggressive form of cancer that can be difficult to diagnose and treat. However, with the latest advances in surgical techniques and chemotherapy, patients with this condition may have a better chance of survival than ever before.

Pleural effusion is the accumulation of fluid within the pleural space between the lungs and chest wall. When this buildup of fluid occurs due to a malignancy (cancer), it is referred to as malignant pleural effusion. This type of effusion is most commonly associated with lung cancer, but can also occur with other types of cancer that have spread (metastasized) to the lungs.

The symptoms of malignant pleural effusion can vary depending on the location and size of the tumor and the amount of fluid accumulated. Common symptoms include:

* Chest pain or discomfort
* Shortness of breath (dyspnea)
* Coughing up blood or pink, frothy liquid (hemoptysis)
* Fatigue
* Weight loss
* Night sweats
* Fevers

A diagnosis of malignant pleural effusion is typically made based on a combination of physical examination findings, medical imaging studies such as chest X-rays or CT scans, and laboratory tests to evaluate the fluid drained from the pleural space.

Treatment for malignant pleural effusion depends on the underlying cause and may include:

* Chemotherapy to shrink the tumor and reduce fluid buildup
* Radiation therapy to target cancer cells in the chest
* Surgery to remove the cancerous tissue or drain the fluid
* Pain management medications to relieve chest pain and discomfort.

Neoplasms, mesothelial refer to abnormal growths or tumors that arise from the mesothelium, a layer of tissue that covers the internal organs and body cavities. These tumors can occur in various parts of the body, such as the pleura (lining of the lungs), peritoneum (lining of the abdominal cavity), or pericardium (lining of the heart sac).

Mesothelial neoplasms are relatively rare compared to other types of cancer, but they can be aggressive and difficult to treat. The most common type of mesothelial neoplasm is malignant mesothelioma, which can arise from any of the three layers of mesothelium. Other less common types include benign mesothelioma and sarcomatoid mesothelioma.

The symptoms of mesothelial neoplasms vary depending on the location and size of the tumor. They may include chest pain, abdominal pain, difficulty breathing, or swelling in the affected area. Diagnosis is typically made through a combination of imaging studies (such as CT scans or PET scans) and biopsy, where a sample of tissue is removed from the tumor for examination under a microscope.

Treatment options for mesothelial neoplasms depend on the location, size, and stage of the tumor, as well as the patient's overall health. Surgery, chemotherapy, and radiation therapy may be used alone or in combination to treat the disease. Prognosis is generally poor for malignant mesothelioma, with a five-year survival rate of less than 10%. However, patients with benign mesothelioma have a better prognosis, with a five-year survival rate of up to 50%.

Lung Neoplasms, also known as lung tumors or pulmonary neoplasms, refer to any abnormal growth of tissue in the lungs that can be benign or malignant. Benign lung neoplasms are non-cancerous and do not spread to other parts of the body, while malignant lung neoplasms are cancerous and have the potential to invade nearby tissues and organs, as well as spread to other parts of the body through the bloodstream or lymphatic system.

There are several types of lung neoplasms, including:

1. Adenocarcinoma: This is the most common type of lung cancer, accounting for approximately 40% of all lung cancers. It is a malignant tumor that originates in the glands of the respiratory tract and can be found in any part of the lung.
2. Squamous cell carcinoma: This type of lung cancer accounts for approximately 25% of all lung cancers and is more common in men than women. It is a malignant tumor that originates in the squamous cells lining the airways of the lungs.
3. Small cell lung cancer (SCLC): This is a highly aggressive form of lung cancer that accounts for approximately 15% of all lung cancers. It is often found in the central parts of the lungs and can spread quickly to other parts of the body.
4. Large cell carcinoma: This is a rare type of lung cancer that accounts for only about 5% of all lung cancers. It is a malignant tumor that originates in the large cells of the respiratory tract and can be found in any part of the lung.
5. Bronchioalveolar carcinoma (BAC): This is a rare type of lung cancer that originates in the cells lining the airways and alveoli of the lungs. It is more common in women than men and tends to affect older individuals.
6. Lymphangioleiomyomatosis (LAM): This is a rare, progressive, and often fatal lung disease that primarily affects women of childbearing age. It is characterized by the growth of smooth muscle-like cells in the lungs and can lead to cysts, lung collapse, and respiratory failure.
7. Hamartoma: This is a benign tumor that originates in the tissue of the lungs and is usually found in children. It is characterized by an overgrowth of normal lung tissue and can be treated with surgery.
8. Secondary lung cancer: This type of cancer occurs when cancer cells from another part of the body spread to the lungs through the bloodstream or lymphatic system. It is more common in people who have a history of smoking or exposure to other carcinogens.
9. Metastatic cancer: This type of cancer occurs when cancer cells from another part of the body spread to the lungs through the bloodstream or lymphatic system. It is more common in people who have a history of smoking or exposure to other carcinogens.
10. Mesothelioma: This is a rare and aggressive form of cancer that originates in the lining of the lungs or abdomen. It is caused by asbestos exposure and can be treated with surgery, chemotherapy, and radiation therapy.

Lung diseases can also be classified based on their cause, such as:

1. Infectious diseases: These are caused by bacteria, viruses, or other microorganisms and can include pneumonia, tuberculosis, and bronchitis.
2. Autoimmune diseases: These are caused by an overactive immune system and can include conditions such as sarcoidosis and idiopathic pulmonary fibrosis.
3. Genetic diseases: These are caused by inherited mutations in genes that affect the lungs and can include cystic fibrosis and primary ciliary dyskinesia.
4. Environmental diseases: These are caused by exposure to harmful substances such as tobacco smoke, air pollution, and asbestos.
5. Radiological diseases: These are caused by exposure to ionizing radiation and can include conditions such as radiographic breast cancer and lung cancer.
6. Vascular diseases: These are caused by problems with the blood vessels in the lungs and can include conditions such as pulmonary embolism and pulmonary hypertension.
7. Tumors: These can be benign or malignant and can include conditions such as lung metastases and lung cancer.
8. Trauma: This can include injuries to the chest or lungs caused by accidents or other forms of trauma.
9. Congenital diseases: These are present at birth and can include conditions such as bronchopulmonary foregut malformations and congenital cystic adenomatoid malformation.

Each type of lung disease has its own set of symptoms, diagnosis, and treatment options. It is important to seek medical attention if you experience any persistent or severe respiratory symptoms, as early diagnosis and treatment can improve outcomes and quality of life.

Occupational diseases refer to health conditions that are caused or made worse by a person's job or work environment. These diseases can be acute or chronic, and can affect any part of the body. Some common examples of occupational diseases include:

1. Asbestosis: a lung disease caused by inhaling asbestos fibers.
2. Carpal tunnel syndrome: a nerve disorder caused by repetitive motion and pressure on the wrist.
3. Mesothelioma: a type of cancer caused by exposure to asbestos.
4. Pneumoconiosis: a lung disease caused by inhaling dust from mining or other heavy industries.
5. Repetitive strain injuries: injuries caused by repetitive motions, such as typing or using vibrating tools.
6. Skin conditions: such as skin irritation and dermatitis caused by exposure to chemicals or other substances in the workplace.
7. Hearing loss: caused by loud noises in the workplace.
8. Back injuries: caused by lifting, bending, or twisting.
9. Respiratory problems: such as asthma and other breathing difficulties caused by exposure to chemicals or dust in the workplace.
10. Cancer: caused by exposure to carcinogens such as radiation, certain chemicals, or heavy metals in the workplace.

Occupational diseases can be difficult to diagnose and treat, as they often develop gradually over time and may not be immediately attributed to the work environment. In some cases, these diseases may not appear until years after exposure has ended. It is important for workers to be aware of the potential health risks associated with their job and take steps to protect themselves, such as wearing protective gear, following safety protocols, and seeking regular medical check-ups. Employers also have a responsibility to provide a safe work environment and follow strict regulations to prevent the spread of occupational diseases.

Pleural Effusion is an accumulation of fluid within the pleural space, which is the thin layer of tissue that lines the lungs and the inside of the chest cavity. The fluid can come from various sources such as inflammation, injury or cancer. It can cause shortness of breath, chest pain and coughing up blood. A diagnosis can be made through a physical examination, imaging tests like X-rays and CT scans and by taking a sample of the fluid with a needle. Treatment depends on the underlying cause and can range from draining the fluid to medications for infection or cancer treatment.

Pleural diseases are a group of conditions that affect the pleura, which is the thin membrane that lines the inside of the chest cavity and covers the lungs. These diseases can cause inflammation, fluid accumulation, or thickening of the pleura, leading to various symptoms such as chest pain, shortness of breath, and coughing.

Some common types of pleural diseases include:

1. Pleurisy: This is an inflammation of the pleura that can be caused by infection, injury, or cancer. Symptoms include chest pain, fever, and difficulty breathing.
2. Pneumothorax: This is a collection of air or gas between the pleural membranes that can cause the lung to collapse. Symptoms include sudden severe chest pain, shortness of breath, and coughing up blood.
3. Empyema: This is an infection of the pleural space that can cause the accumulation of pus and fluid. Symptoms include fever, chills, and difficulty breathing.
4. Mesothelioma: This is a type of cancer that affects the pleura and can cause symptoms such as chest pain, shortness of breath, and weight loss.
5. Pleural effusion: This is the accumulation of fluid in the pleural space that can be caused by various conditions such as infection, heart failure, or cancer. Symptoms include chest pain, shortness of breath, and coughing up fluid.

Pleural diseases can be diagnosed through various tests such as chest X-rays, CT scans, and pleuroscopy (a minimally invasive procedure that uses a thin tube with a camera and light on the end to examine the pleura). Treatment options vary depending on the underlying cause of the disease and can include antibiotics, surgery, or radiation therapy.

Pleurisy is inflammation of the pleura, which is a thin membrane that lines the inside of the chest cavity and covers the lungs. It can be caused by a variety of factors, such as viral or bacterial infections, pneumonia, or injury to the chest wall. Symptoms of pleurisy may include chest pain, coughing, shortness of breath, and fever. Treatment typically involves antibiotics if the cause is a bacterial infection, as well as supportive care such as pain management and rest. In severe cases, surgery may be necessary to remove fluid or adhesions that have developed in the pleural space.

Testicular hydrocele is a condition where fluid accumulates within a sac that forms around the testicle, causing it to swell. This condition is usually present at birth but can also occur later in life due to injury or infection. It is more common in males and can be diagnosed through physical examination and imaging tests such as ultrasound or MRI.

Symptoms of testicular hydrocele may include:

* A swollen testicle
* Painless lump in the scrotum
* Difficulty moving the testicle
* Discomfort or pain in the scrotum or groin area

If you suspect that you or your child has testicular hydrocele, it is important to seek medical attention as soon as possible. A healthcare professional will perform a physical examination and may order imaging tests to confirm the diagnosis and determine the cause of the condition. Treatment options for testicular hydrocele may include:

* Watchful waiting: If the hydrocele is small and not causing any discomfort, your healthcare provider may recommend monitoring the condition closely without immediate treatment.
* Surgery: In some cases, surgery may be necessary to remove the fluid and repair any damage to the testicle.
* Antibiotics: If the hydrocele is caused by an infection, antibiotics may be prescribed to treat the infection.

It is important to seek medical attention if you experience any of the following symptoms, as they could be a sign of a more serious condition:

* Fever
* Pain or discomfort in the scrotum or groin area
* Difficulty urinating
* Redness or swelling of the skin around the testicle

Understanding the definition and symptoms of testicular hydrocele can help you identify this condition early on and seek appropriate medical attention if necessary. If you suspect that you or your child has testicular hydrocele, do not hesitate to consult with a healthcare professional for proper diagnosis and treatment.

Pleural MesotheliomaTumorsExposure to asbestosLung cancerPeritoneal mesotheliomaDiagnosisAsbestosisExposed to asbestosAggressiveCancersChemotherapy2023TreatmentClinical TrialsLungsMesotheliumAffectsLawsuitsTunica vaginalisLawyersPatientsCentersCompensationsOrgansAbdomenCompensation2001NanoparticlesSymptoms of MesotheliomaFoundOccursTissueLitigationLawyerDiseasesChest3,000IncludeFormRisksCasesVictimsLawsuitTendencyRaising awarenessResearch
Pleural Mesothelioma15
  • Genomic Instability and Protumoral Inflammation Are Associated with Primary Resistance to Anti-PD-1 + Antiangiogenesis in Malignant Pleural Mesothelioma. (nih.gov)
  • He, along with Heather and young Lily, had their worlds turned upside down when Heather was diagnosed with malignant pleural mesothelioma, just 3 1/2 months after the birth of his only child. (mesothelioma.com)
  • Two-thirds of the time, the cancer manifests in the membrane lining the lungs (pleural mesothelioma), and most other cases are found in the abdomen. (bu.edu)
  • Results of final clinical trials for the drug released May 20 showed patients receiving the drug, chemotherapy medicine and vitamins lived 13 months after being diagnosed with pleural mesothelioma . (mesotheliomaweb.org)
  • Pleural mesothelioma, which affects nearly 75 percent of all mesothelioma patients, attacks the linings of a person's lungs, called the mesothelium. (sokolovelaw.com)
  • Symptoms of pleural mesothelioma include short-ness of breath and chest pain. (carle.org)
  • Dr. Harvey Pass is a thoracic surgeon and leading pleural mesothelioma expert, involved in clinical trials finding new ways to diagnose and treat the rare cancer. (maacenter.org)
  • Dr. Harvey Pass has been dedicated to conducting innovative research for pleural mesothelioma and lung cancer since the start of his career. (maacenter.org)
  • One of his most significant breakthroughs for mesothelioma research occurred during his time at Karmanos Cancer Institute, when his research team identified a protein (osteopontin) that presents at elevated levels in patients with pleural mesothelioma. (maacenter.org)
  • The discovery allows doctors to use blood tests to diagnose pleural mesothelioma earlier in patients with a history of asbestos exposure. (maacenter.org)
  • A diagnosis of pleural mesothelioma - an aggressive form of cancer caused by asbestos exposure - shocked our clients. (weitzlux.com)
  • The main cause of pleural mesothelioma is asbestos exposure. (customerservicemanager.com)
  • An epidemiological and environmental study was carried out in Shubra El-Kheima city, greater Cairo, of the exposure-response relationship between asbestos and malignant pleural mesothelioma. (who.int)
  • Malignant pleural mesothelioma (MPM) is associated with environmental and occupational exposure to asbestos [1]. (who.int)
  • Malignant pleural mesothelioma (MPM) is a highly aggressive cancer, accounting for 3,000 deaths in the US annually. (nih.gov)
Tumors7
  • In cases of peritoneal mesothelioma, which affects the membrane lining the abdominal cavity and is diagnosed in about 600 people a year in the United States , surgeons open a patient's belly to remove visible tumors and insert a catheter. (bu.edu)
  • Tumor Cell With peritoneal mesothelioma, tumors form along the thin membrane surrounding the abdominal cavity. (bu.edu)
  • Mesothelioma results in tumors, usually caused by asbestos fibers lodged in the lung, which attach to the lung lining and chest wall. (mesotheliomaweb.org)
  • Recent medical research out of Boston may point to an improvement of chemotherapy effectiveness in the treatment of mesothelioma cancer tumors when the drugs are delivered after doctors have injected nanoparticles into the tumors beforehand. (braytonlaw.com)
  • Mesothelioma tumors develop in the linings around internal organs, usually around the lungs, chest or abdomen, and even more rarely surrounding the heart or testicles. (braytonlaw.com)
  • In mesothelioma and related cancers, chemotherapeutic drugs injected alone do not tend to concentrate well in tumors, according to researchers affiliated with Boston University and Brigham and Women's Hospital in Boston who conducted the study, published in a January 2016 article in Scientific Reports. (braytonlaw.com)
  • Researchers linked asbestos exposure to an increased incidence of lung tumors and mesotheliomas, and found that asbestos-exposed workers who smoke cigarettes have a risk of lung cancer more than ten times as great as asbestos-exposed individuals who do not smoke. (nih.gov)
Exposure to asbestos7
  • Exposure to asbestos causes most cases of mesothelioma. (cdc.gov)
  • Often detected at a late stage, mesothelioma is linked to exposure to asbestos, a substance commonly found in insulation, shingles, and flooring made before 1989. (bu.edu)
  • If multiple members of a certain family develop mesothelioma, it is likely that this is due to secondhand exposure to asbestos. (sokolovelaw.com)
  • Mesothelioma is a terminal form of cancer that is caused by exposure to asbestos. (sokolovelaw.com)
  • Most commonly mesothelioma is caused by repeated and prolonged exposure to asbestos, and such extended exposure typically occurs at one's workplace, where asbestos is being mined or used in manufacturing on a consistent basis. (sokolovelaw.com)
  • The prevalence of mesothelioma increased with increased cumulative exposure to asbestos. (who.int)
  • Pleural mesotheliomas have been linked to exposure to asbestos. (nih.gov)
Lung cancer10
  • Sometimes it is hard to tell the difference between malignant mesothelioma and lung cancer. (nih.gov)
  • Q. Is mesothelioma a type of lung cancer? (cancercare.org)
  • Like in the group's lung cancer project , the mesothelioma team is developing a targeted method for delivering drugs directly to tumor cells. (bu.edu)
  • Breathing in stray asbestos fibers after they have been disturbed can lead to several fatal diseases, including asbestos-caused lung cancer, mesothelioma, and asbestosis. (sokolovelaw.com)
  • During his extensive medical career, Dr. Pass has focused his research into distinct areas, like biomarkers for mesothelioma detection and surgical techniques to treat mesothelioma and various types of lung cancer. (maacenter.org)
  • Dr. Pass has focused his studies on discovering new potential biomarkers for lung cancer and mesothelioma to allow for early screenings of the disease and faster diagnosis. (maacenter.org)
  • Since 1998, Dr. Pass has also had his research continuously funded by the National Cancer Institute, Centers of Disease Control and Prevention and the U.S. Department of Defense for mesothelioma and lung cancer. (maacenter.org)
  • Diagnosed with Mesothelioma or Lung Cancer from Asbestos? (mesotheliomatreatmentcenters.org)
  • ALERT: We are curently filing mesothelioma, lung cancer and asbestosis claims during the coronavirus / COVID-19 pandemic. (mesotheliomatreatmentcenters.org)
  • The airborne asbestos fibers can lodge themselves in the lungs and other internal organs, where they may begin a disease process that culminates in asbestosis, lung cancer, or mesothelioma cancer . (mesotheliomatreatmentcenters.org)
Peritoneal mesothelioma5
  • Genomic landscape of pleural and peritoneal mesothelioma tumours. (nih.gov)
  • Colby hopes to be among the researchers who find a better treatment for late-stage peritoneal mesothelioma. (bu.edu)
  • The Grinstaff Group is focusing on the less common peritoneal mesothelioma because it's easier to isolate (it doesn't metastasize like other cancers) and therefore easier to attack with an innovative drug delivery system. (bu.edu)
  • A New York man diagnosed with peritoneal mesothelioma has been awarded $2 million in an asbestos lawsuit brought against a Canadian mining company. (aboutlawsuits.com)
  • A Florida jury has awarded a Sarasota construction worker $14 million in a peritoneal mesothelioma lawsuit against Union Carbide. (aboutlawsuits.com)
Diagnosis8
  • The diagnosis of mesothelioma should be made with care. (medscape.com)
  • A clinical history of asbestos exposure and radiologic findings that are consistent with mesothelioma warrant inclusion of mesothelioma in the differential diagnosis, but it is important to stress that a diagnosis of mesothelioma cannot be made exclusively with imaging studies. (medscape.com)
  • Biopsy with special staining and immunohistochemical and ultrastructural analysis are absolutely essential for the accurate diagnosis of mesothelioma. (medscape.com)
  • Without an early mesothelioma diagnosis, however, treatment options are limited to chemotherapy or radiation. (pleuralmesothelioma.com)
  • Almost half of the patients with testicular mesothelioma survive for five or more years after diagnosis, while 33% survive at least 10 years. (pleuralmesothelioma.com)
  • The majority of patients have a diagnosis of epithelial cell type, which has a more favorable mesothelioma prognosis and a better response to treatment than other variants. (pleuralmesothelioma.com)
  • If I was to receive a grim diagnosis, such as O'Connor did when he received his mesothelioma diagnosis, I would take and OWN my diagnosis, but know that my diagnosis was just a part of what is going on with me. (survivingmesothelioma.com)
  • Malignant mesothelioma is a highly aggressive form of cancer with poor prognosis due to lack of markers for early diagnosis and resistance to conventional therapies. (nih.gov)
Asbestosis1
  • Mesothelioma and its association with asbestosis. (nih.gov)
Exposed to asbestos4
  • Not everyone who is exposed to asbestos will get mesothelioma or other cancers. (cdc.gov)
  • Wagner et al connected asbestos to mesothelioma in a classic 1960 study of 33 patients with mesothelioma who were exposed to asbestos in a mining area in South Africa's North Western Cape Province. (medscape.com)
  • If you have been exposed to asbestos in consumer products, the environment, or from working in an industry likely to be exposed to asbestos -- like construction, mining, manufacturing, longshore -- and have developed health issues resulting from asbestos exposure, an asbestos and mesothelioma lawyer can help. (findlaw.com)
  • People who worked at and around the DEW stations may have been exposed to asbestos and were put at risk of developing mesothelioma . (mesothelioma.net)
Aggressive4
  • Mesothelioma Symptoms was founded by a team of advocates to educate people about this aggressive form of cancer. (mesotheliomasymptoms.com)
  • Mesothelioma of the tunica vaginalis is an aggressive form of cancer, and 52% of patients develop local recurrence or metastasis. (pleuralmesothelioma.com)
  • Mesothelioma often does not manifest until its victim is elderly, making aggressive treatment even more taxing. (braytonlaw.com)
  • Mesothelioma is an aggressive and incurable form of cancer. (customerservicemanager.com)
Cancers6
  • It can be hard to tell the difference between mesothelioma and other cancers. (cdc.gov)
  • As is the case with all cancers, mesothelioma is not contagious. (sokolovelaw.com)
  • While some cancers can be hereditary, such as breast and ovarian cancer, mesothelioma is not hereditary. (sokolovelaw.com)
  • Mesothelioma can be treated, like most cancers, though the treatment's effectiveness varies depending on what stage the cancer has advanced to. (sokolovelaw.com)
  • It eventually became apparent that exposure to this mineral resulted in dangerous health complications, including a number of cancers like mesothelioma, which is notable for its low survival rate . (eco.ca)
  • Fewer medical professionals are familiar with mesothelioma than with other cancers. (braytonlaw.com)
Chemotherapy3
  • In a fifth floor lab in the Metcalf Center for Science and Engineering, Colby and Ekladious don white coats, goggles, and purple latex gloves as they prepare a batch of nanoparticles loaded with paclitaxel, one of the chemotherapy drugs used to treat mesothelioma. (bu.edu)
  • According to a 2004 published review in one of the world's leading medical journals, The Lancet, it was written that "For the treatment of mesothelioma, there is little evidence that current therapies (chemotherapy, radiation, surgery) provide significant benefit for survival or quality of life. (survivingmesothelioma.com)
  • This two-step approach to chemotherapy for mesothelioma was successful in the laboratory and in mice. (braytonlaw.com)
20231
Treatment10
  • Treatment depends on where the mesothelioma is located and whether it has spread to other parts of the body. (cdc.gov)
  • Learn more about mesothelioma through the National Cancer Institute's Malignant Mesothelioma Treatment (PDQ®) . (cancercare.org)
  • Our patient advocates have over 20 years of successfully guiding mesothelioma patients to access treatment and pursue compensation. (mesotheliomasymptoms.com)
  • The best treatment option for mesothelioma patients with early-stage cancer is surgery. (pleuralmesothelioma.com)
  • Malignant mesothelioma has largely defeated treatment…" This was not acceptable to Rhio O'Connor, nor was the advice from his oncologist - to take his wife on a nice cruise and begin hospice care upon his return. (survivingmesothelioma.com)
  • This study aims to develop poly lactic-co-glycolic acid (PLGA) nanoparticles with an innovative imaging-guided approach based on Boron Neutron Capture Therapy for the treatment of mesothelioma. (nih.gov)
  • Treatment options for mesothelioma are determined by the age and healthiness of the patient, the stage of the cancer, whether or not the cancer seems resectable (removable through surgery), and the probability of a given treatment method to help improve the state of the patient. (sokolovelaw.com)
  • As we've written about on this blog before, building awareness about mesothelioma is paramount in the effort to keep people safer from asbestos and get mesothelioma patients better treatment options. (simmonsfirm.com)
  • The results of recent research into the combination of nanoparticles and chemotherapeutic drugs in mesothelioma treatment are positive. (braytonlaw.com)
  • Contact mesothelioma treatment centers today for more information about firefighters, asbestos exposure, and asbestos cancer illnesses. (mesotheliomatreatmentcenters.org)
Clinical Trials2
  • His research in clinical trials to find groundbreaking ways to diagnose and treat mesothelioma , as well as his tenured experience as a leading thoracic surgeon has allowed Dr. Pass to help numerous mesothelioma patients and their loved ones. (maacenter.org)
  • These results strongly imply that heparanase plays an important role in mesothelioma tumor progression, thus encouraging the use of heparanase inhibitors in combination with existing drugs as a new therapeutic modality in mesothelioma clinical trials. (nih.gov)
Lungs4
  • The most common kind of mesothelioma forms in the tissue around the lungs, called the pleura. (cdc.gov)
  • Mesothelioma is a cancer that affects the mesothelium, the tissue that lines the lungs, abdomen, and heart. (sokolovelaw.com)
  • Mesothelioma can be localized (found only on the membrane) or advanced (spread to lymph nodes, lungs, chest wall, or abdominal organs). (carle.org)
  • Mesothelioma most often occurs in the pleura, which is the tissue that surrounds the lungs. (customerservicemanager.com)
Mesothelium3
  • Peritoneal cystic mesothelioma (BMPM) is a very rare benign cystic tumor arising from the peritoneal mesothelium (lining of the abdominal wall). (nih.gov)
  • According to www.survivingmesothelioma.com, mesothelioma is a rare form of cancer in which malignant cells are found in the mesothelium, the protective sac that covers most of the body's internal organs. (survivingmesothelioma.com)
  • Mesothelioma is a rare cancer that affects the mesothelium. (carle.org)
Affects2
  • Mesothelioma affects thousands of people each year. (mesotheliomasymptoms.com)
  • Testicular mesothelioma, a rare form of the disease, affects the tunica vaginalis in the testes and accounts for less than 5% of all cases. (pleuralmesothelioma.com)
Lawsuits4
  • They have experience and are knowledgeable about the complexities, medical consideration, as well as history surrounding the Mesothelioma lawsuits, case law, as well as the relevant practical procedure rules and paperwork required of every case they hold. (bartleby.com)
  • It has been seen that mesothelioma lawsuits can win millions in remuneration for the casualties and their families. (bartleby.com)
  • These include mesothelioma lawsuits, mesothelioma settlements, and asbestos trust funds. (customerservicemanager.com)
  • At the end of a trial, mesothelioma lawsuits are decided by the jury. (customerservicemanager.com)
Tunica vaginalis7
  • Signs of malignant mesothelioma of the tunica vaginalis are similar to other disorders of the testes. (pleuralmesothelioma.com)
  • Malignant mesothelioma of the tunica vaginalis does not have a unique set of symptoms and presents similarly to more common testicular diseases. (pleuralmesothelioma.com)
  • Testicular mesothelioma forms on the membrane that lines the testes called the tunica vaginalis. (pleuralmesothelioma.com)
  • Testicular mesothelioma develops as hard yellowish lesions on the surface of the tunica vaginalis. (pleuralmesothelioma.com)
  • The prognosis for malignant mesothelioma of the tunica vaginalis is substantially more favorable than other types. (pleuralmesothelioma.com)
  • Median life expectancy for mesothelioma of the tunica vaginalis is about 24 months. (pleuralmesothelioma.com)
  • Due to the similarity of symptoms with other types of testicular disease, diagnosing mesothelioma of the tunica vaginalis can be difficult. (pleuralmesothelioma.com)
Lawyers5
  • Experienced Extremely experienced Mesothelioma lawyers win highest compensations for their clients. (bartleby.com)
  • These days there are various mesothelioma lawyers who are masters in these cases and can get the most extreme remuneration for you. (bartleby.com)
  • Please select a city to find local Massachusetts Asbestos Mesothelioma lawyers. (findlaw.com)
  • Alaska mesothelioma lawyers are experts in the related laws and have proven experience helping victims file successful claims. (mesothelioma.net)
  • Alaska mesothelioma lawyers know where exposure occurred. (mesothelioma.net)
Patients4
  • The clinical latency period between asbestos exposure and mesothelioma development is 35-40 years, and as a result, the number of mesothelioma patients has continued to rise despite decreased asbestos production. (medscape.com)
  • Phase II trial to study the effectiveness of gefitinib in treating patients who have malignant mesothelioma. (clinicaltrials.gov)
  • I. Determine the activity of gefitinib, in terms of failure-free survival, in patients with malignant mesothelioma. (clinicaltrials.gov)
  • Three out of five mesothelioma patients do not get surgical therapy that could add three years to their lives, according to the findings of a new study. (aboutlawsuits.com)
Centers1
  • The Centers for Disease Control and Prevention (CDC), National Institute for Occupational Safety and Health (NIOSH) announces the availability of funds for fiscal year (FY) 2006 to support cooperative agreement (U19) applications for the establishment of a National Mesothelioma Virtual Tissue Bank and Registry. (nih.gov)
Compensations2
Organs2
  • Mesothelioma is a cancer that forms in the thin tissue that lines many of your internal organs. (cdc.gov)
  • Other types of mesothelioma affect tissue in the abdomen the heart, and other organs. (customerservicemanager.com)
Abdomen2
  • Malignant mesothelioma forms in the tissue that lines the chest or abdomen. (cdc.gov)
  • Symptoms of mesothelioma are severe and can include significant pain, shortness of breath, excess fluid in the chest or abdomen, coughing, swelling, blood clots, weight loss, marked fatigue and others. (braytonlaw.com)
Compensation7
  • Use FindLaw to hire a local asbestos lawyer near you to seek compensation for medical expenses resulting from asbestos exposure or mesothelioma cancer. (findlaw.com)
  • Individuals who have been diagnosed with mesothelioma are eligible to file a compensation claim. (customerservicemanager.com)
  • On a general note, mesothelioma compensation payouts are determined based on a set of factors such as the occupational history of the plaintiff, military service, history of asbestos exposure , and the type of asbestos claim filed. (customerservicemanager.com)
  • If the person diagnosed with mesothelioma dies, their family or spouse can receive compensation through a wrongful death lawsuit. (customerservicemanager.com)
  • It usually takes up to a year for the plaintiff to receive a mesothelioma compensation either from trust funds and settlements. (customerservicemanager.com)
  • An Alaska mesothelioma lawyer can help you seek a settlement or other type of compensation for asbestos exposure and illness. (mesothelioma.net)
  • If your exposure occurred during active military service, claim with the VA for compensation and other benefits, like healthcare from mesothelioma specialists. (mesothelioma.net)
20011
  • James "Rhio" O'Connor chose to see the opportunities when he was diagnosed with mesothelioma in October, 2001. (survivingmesothelioma.com)
Nanoparticles1
  • The herein-reported results demonstrate that PLGA nanoparticles incorporating oligo-histidine chains and the dual Gd/B theranostic agent AT101 can successfully be exploited to deliver a therapeutic dose of boron to mesothelioma cells, significantly higher than in healthy mesothelial cells as assessed by ICP-MS and MRI. (nih.gov)
Symptoms of Mesothelioma1
  • What Are the Symptoms of Mesothelioma? (cdc.gov)
Found3
  • Malignant mesothelioma is often found when it is advanced. (nih.gov)
  • Can Malignant Mesothelioma Be Found Early? (nih.gov)
  • We found that mesothelioma tumor growth was markedly attenuated by heparanase gene silencing and by heparanase inhibitors. (nih.gov)
Occurs3
Tissue3
  • Malignant mesothelioma may also form in the tissue that surrounds the heart (the pericardium ) or the testicles, but this is rare. (cdc.gov)
  • Mesothelioma, also known as malignant mesothelioma, is cancer of that tissue. (nih.gov)
  • The purpose of the virtual Tissue Bank and Registry is to maximize the effectiveness of data collection and serve as a resource that will allow researchers real time access to clinical data associated with tissue specimens from the registry, thus expanding scientific discovery and effective treatments to benefit the mesothelioma research and patient community. (nih.gov)
Litigation3
  • There are attorneys who specialize in Mesothelioma cases or asbestos litigation. (bartleby.com)
  • Simmons Hanly Conroy's support blog is a place for clients and families to find news, education, and inspirational stories about the following areas of litigation: mesothelioma and asbestos, dangerous drugs and devices, consumer protection and mass torts, personal injury and environmental litigation. (simmonsfirm.com)
  • If you are looking for an asbestos attorney, you can get legal advice who specializes in mesothelioma litigation. (customerservicemanager.com)
Lawyer1
  • It is at this time the need for choosing a good Mesothelioma Lawyer becomes imperative. (bartleby.com)
Diseases2
  • More common diseases, such as benign asbestos-related pleural disease and metastatic adenocarcinoma , can look radiographically identical to mesothelioma. (medscape.com)
  • The radiographic findings of mesothelioma are nonspecific and are observed in other diseases, including metastatic carcinoma, lymphoma, and benign asbestos disease. (medscape.com)
Chest1
  • Mesothelioma is a rare form of cancer which develops in the lining of the chest and lung . (cancercare.org)
3,0001
Include3
  • The increase with mesothelioma situations coming to gentle has witnessed a new rate of growth with the number of consultant mesothelioma legal professionals functioning, along with these kinds of knowledgeable experts include piled up proven back links to aid using numerous aspects of your current mesothelioma lawsuit. (bartleby.com)
  • Signs and symptoms of perito-neal mesothelioma include weight loss, abdominal pain and swelling, bowel obstruction, blood clotting abnormalities, anemia, and fever. (carle.org)
  • Applications of the technology include models for screening compounds as potential therapeutics for mesothelioma and for studying the pathology of mesothelioma. (nih.gov)
Form5
  • Researchers are still working to understand how asbestos fibers cause mesothelioma to form in the testes. (pleuralmesothelioma.com)
  • If the treating physician suspects their patient has this rare form of mesothelioma, they will order imaging, such as an ultrasound, to investigate irregularities. (pleuralmesothelioma.com)
  • Mesothelioma is an ultimately fatal form of cancer. (sokolovelaw.com)
  • Mesothelioma kills because it is a terminal form of cancer. (sokolovelaw.com)
  • If these fibers are inhaled or ingested, the result could be a particularly deadly form of cancer called mesothelioma. (sokolovelaw.com)
Risks1
  • The Mesothelioma.com editorial team works hard to offer current, factual, expert reviewed information about mesothelioma cancer and the risks of asbestos exposure. (mesothelioma.com)
Cases3
  • See rates or numbers of new cases or deaths from mesothelioma for the entire United States and individual states. (cdc.gov)
  • Due to the limited number of observed cases, there is no formal mesothelioma staging system for the testicular variant of the disease. (pleuralmesothelioma.com)
  • There were 88 cases of mesothelioma diagnosed, 87 in the exposed group. (who.int)
Victims2
  • Mesothelioma Resource Group is dedicated to helping mesothelioma victims and their families. (mesotheliomasymptoms.com)
  • More than half of all mesothelioma victims die within 18 months of discovery. (sokolovelaw.com)
Lawsuit1
  • As indicated by Houston's law specialists, on the off chance that you are determined to have mesothelioma you have each privilege to record a lawsuit in the court. (bartleby.com)
Tendency2
  • A type of mesothelioma with a tendency to metastasize. (nih.gov)
  • One reason mesothelioma can be challenging to treat is its tendency to spread from the tumor of origin to other internal surfaces, the blood and nervous system, making complete eradication of the involved cancer cells elusive. (braytonlaw.com)
Raising awareness1
  • Mesothelioma.com is dedicated to providing the latest mesothelioma information and free resources while raising awareness of the dangers of asbestos. (mesothelioma.com)
Research5
  • The Mesothelioma Applied Research Foundation also provides information and patient stories. (cancercare.org)
  • After a decade with the National Cancer Institute, Dr. Pass moved to Detroit to lead mesothelioma research at the Karmanos Cancer Institute from 1996 to 2005. (maacenter.org)
  • During this time, Dr. Pass was also part of a group that helped lead to the development of the Mesothelioma Applied Research Foundation. (maacenter.org)
  • The second step in filing a mesothelioma claim is to thoroughly research the details of your claim. (customerservicemanager.com)
  • The National Cancer Institute is seeking parties interested in collaborative research to co-develop, evaluate, or commercialize a new mouse model for monoclonal antibodies and immunoconjugates that target malignant mesotheliomas. (nih.gov)