One of a pair of excretory organs (mesonephroi) which grows caudally to the first pair (PRONEPHROI) during development. Mesonephroi are the permanent kidneys in adult amphibians and fish. In higher vertebrates, proneprhoi and most of mesonephroi degenerate with the appearance of metanephroi. The remaining ducts become WOLFFIAN DUCTS.
The gamete-producing glands, OVARY or TESTIS.
A pair of excretory ducts of the middle kidneys (MESONEPHROI) of an embryo, also called mesonephric ducts. In higher vertebrates, Wolffian ducts persist in the male forming VAS DEFERENS, but atrophy into vestigial structures in the female.
All the organs involved in reproduction and the formation and release of URINE. It includes the kidneys, ureters, BLADDER; URETHRA, and the organs of reproduction - ovaries, UTERUS; FALLOPIAN TUBES; VAGINA; and CLITORIS in women and the testes; SEMINAL VESICLES; PROSTATE; seminal ducts; and PENIS in men.
Common name for two distinct groups of BIRDS in the order GALLIFORMES: the New World or American quails of the family Odontophoridae and the Old World quails in the genus COTURNIX, family Phasianidae.
The process in developing sex- or gender-specific tissue, organ, or function after SEX DETERMINATION PROCESSES have set the sex of the GONADS. Major areas of sex differentiation occur in the reproductive tract (GENITALIA) and the brain.
Small masses of chromaffin cells found near the SYMPATHETIC GANGLIA along the ABDOMINAL AORTA, beginning cranial to the superior mesenteric artery (MESENTERIC ARTERY, SUPERIOR) or renal arteries and extending to the level of the aortic bifurcation or just beyond. They are also called the organs of Zuckerkandl and sometimes called aortic bodies (not to be confused with AORTIC BODIES in the THORAX). The para-aortic bodies are the dominant source of CATECHOLAMINES in the FETUS and normally regress after BIRTH.
An extra-embryonic membranous sac derived from the YOLK SAC of REPTILES; BIRDS; and MAMMALS. It lies between two other extra-embryonic membranes, the AMNION and the CHORION. The allantois serves to store urinary wastes and mediate exchange of gas and nutrients for the developing embryo.
The developmental entity of a fertilized chicken egg (ZYGOTE). The developmental process begins about 24 h before the egg is laid at the BLASTODISC, a small whitish spot on the surface of the EGG YOLK. After 21 days of incubation, the embryo is fully developed before hatching.
A transcription factor that plays an essential role in the development of the TESTES. It is encoded by a gene on the Y chromosome and contains a specific HMG-BOX DOMAIN that is found within members of the SOX family of transcription factors.
The male gonad containing two functional parts: the SEMINIFEROUS TUBULES for the production and transport of male germ cells (SPERMATOGENESIS) and the interstitial compartment containing LEYDIG CELLS that produce ANDROGENS.
A technique for maintenance or growth of animal organs in vitro. It refers to three-dimensional cultures of undisaggregated tissue retaining some or all of the histological features of the tissue in vivo. (Freshney, Culture of Animal Cells, 3d ed, p1)
The middle germ layer of an embryo derived from three paired mesenchymal aggregates along the neural tube.
A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.
The farthest or outermost projections of the body, such as the HAND and FOOT.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.
Morphological and physiological development of EMBRYOS or FETUSES.
The development of anatomical structures to create the form of a single- or multi-cell organism. Morphogenesis provides form changes of a part, parts, or the whole organism.
Microscopy in which the object is examined directly by an electron beam scanning the specimen point-by-point. The image is constructed by detecting the products of specimen interactions that are projected above the plane of the sample, such as backscattered electrons. Although SCANNING TRANSMISSION ELECTRON MICROSCOPY also scans the specimen point by point with the electron beam, the image is constructed by detecting the electrons, or their interaction products that are transmitted through the sample plane, so that is a form of TRANSMISSION ELECTRON MICROSCOPY.
The reproductive organ (GONADS) in female animals. In vertebrates, the ovary contains two functional parts: the OVARIAN FOLLICLE for the production of female germ cells (OOGENESIS); and the endocrine cells (GRANULOSA CELLS; THECA CELLS; and LUTEAL CELLS) for the production of ESTROGENS and PROGESTERONE.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
An abdominal hernia with an external bulge in the GROIN region. It can be classified by the location of herniation. Indirect inguinal hernias occur through the internal inguinal ring. Direct inguinal hernias occur through defects in the ABDOMINAL WALL (transversalis fascia) in Hesselbach's triangle. The former type is commonly seen in children and young adults; the latter in adults.
Time period from 1501 through 1600 of the common era.
Protrusion of tissue, structure, or part of an organ through the bone, muscular tissue, or the membrane by which it is normally contained. Hernia may involve tissues such as the ABDOMINAL WALL or the respiratory DIAPHRAGM. Hernias may be internal, external, congenital, or acquired.
Protrusion of abdominal structures into the THORAX as a result of congenital or traumatic defects in the respiratory DIAPHRAGM.
A hernia caused by weakness of the anterior ABDOMINAL WALL due to midline defects, previous incisions, or increased intra-abdominal pressure. Ventral hernias include UMBILICAL HERNIA, incisional, epigastric, and spigelian hernias.
A protrusion of abdominal structures through the retaining ABDOMINAL WALL. It involves two parts: an opening in the abdominal wall, and a hernia sac consisting of PERITONEUM and abdominal contents. Abdominal hernias include groin hernia (HERNIA, FEMORAL; HERNIA, INGUINAL) and VENTRAL HERNIA.
A groin hernia occurring inferior to the inguinal ligament and medial to the FEMORAL VEIN and FEMORAL ARTERY. The femoral hernia sac has a small neck but may enlarge considerably when it enters the subcutaneous tissue of the thigh. It is caused by defects in the ABDOMINAL WALL.

In vitro hematopoietic and endothelial cell development from cells expressing TEK receptor in murine aorta-gonad-mesonephros region. (1/184)

Recent studies have shown that long-term repopulating hematopoietic stem cells (HSCs) first appear in the aorta-gonad-mesonephros (AGM) region. Our immunohistochemistry study showed that TEK+ cells existed in the AGM region. Approximately 5% of AGM cells were TEK+, and most of these were CD34(+) and c-Kit+. We then established a coculture system of AGM cells using a stromal cell line, OP9, which is deficient in macrophage colony-stimulating factor (M-CSF). With this system, we showed that AGM cells at 10.5 days postcoitum (dpc) differentiated and proliferated into both hematopoietic and endothelial cells. Proliferating hematopoietic cells contained a significant number of colony-forming cells in culture (CFU-C) and in spleen (CFU-S). Among primary AGM cells at 10.5 dpc, sorted TEK+ AGM cells generated hematopoietic cells and platelet endothelial cell adhesion molecule (PECAM)-1(+) endothelial cells on the OP9 stromal layer, while TEK- cells did not. When a ligand for TEK, angiopoietin-1, was added to the single-cell culture of AGM, endothelial cell growth was detected in the wells where hematopoietic colonies grew. Although the incidence was still low (1/135), we showed that single TEK+ cells generated hematopoietic cells and endothelial cells simultaneously, using a single-cell deposition system. This in vitro coculture system shows that the TEK+ fraction of primary AGM cells is a candidate for hemangioblasts, which can differentiate into both hematopoietic cells and endothelial cells.  (+info)

Selective expression of purinoceptor cP2Y1 suggests a role for nucleotide signalling in development of the chick embryo. (2/184)

Responses to extracellular nucleotides (e.g., ATP, ADP, etc.) have been demonstrated in a number of embryonic cell types suggesting they may be important signalling molecules during embryonic development. Here the authors describe for the first time the expression of a G-protein-coupled receptor for extracellular ATP, chick P2Y1 (cP2Y1), during embryonic development of the chick. During the first 10 days of embryonic development, cP2Y1 is expressed in a developmentally regulated manner in the limb buds, mesonephros, brain, somites, and facial primordia, suggesting that this receptor may have a role in the development of each of these systems.  (+info)

Mesonephric cell migration induces testis cord formation and Sertoli cell differentiation in the mammalian gonad. (3/184)

In mammals a single gene on the Y chromosome, Sry, controls testis formation. One of the earliest effects of Sry expression is the induction of somatic cell migration from the mesonephros into the XY gonad. Here we show that mesonephric cells are required for cord formation and male-specific gene expression in XY gonads in a stage-specific manner. Culturing XX gonads with an XY gonad at their surface, as a 'sandwich', resulted in cell migration into the XX tissue. Analysis of sandwich gonads revealed that in the presence of migrating cells, XX gonads organized cord structures and acquired male-specific gene expression patterns. From these results, we conclude that mesonephric cell migration plays a critical role in the formation of testis cords and the differentiation of XY versus XX cell types.  (+info)

The mouse GATA-2 gene is expressed in the para-aortic splanchnopleura and aorta-gonads and mesonephros region. (4/184)

We previously reported that the mouse GATA-2 gene is regulated by two alternative promoters (Minegishi et al, J Biol Chem, 273:3625, 1998). Although the more proximal IG (general) promoter is active in almost all GATA-2-expressing cells, the distal IS (specific) promoter activity was selectively detected in hematopoietic tissues but not in other mesodermal tissues. We report here in vivo analysis of the GATA-2 locus and its regulatory characteristics in hematopoietic tissues of transgenic mice. Transgenes containing 6 or 7 kbp of sequence flanking the 5' end of the IS first exon direct expression of beta-galactosidase or green fluorescent protein (GFP) reporter genes specifically to the para-aortic splanchnopleura, aorta-gonads, and mesonephros (AGM) region, and in the neural tissues. In situ hybridization analysis showed that reporter gene expression specifically recapitulates the endogenous expression profile of GATA-2 in these tissues. The flk-1, CD34, c-kit, and CD45 antigens were identified in the GFP-positive cells from the AGM region and fetal liver, indicating that GATA-2 is expressed in immature hematopoietic cells. Deletion of 3.5 kbp from the 5' end of the 6.0 kbp IS promoter construct, including one of the DNase I hypersensitive sites, completely abolished hematopoietic expression. These experiments describe an early developmental GATA-2 hematopoietic enhancer located between 6.0 and 2.5 kbp 5' to the IS exon.  (+info)

Detailed characterization of the human aorta-gonad-mesonephros region reveals morphological polarity resembling a hematopoietic stromal layer. (5/184)

The definitive long-term repopulating human hematopoietic stem cell, which seeds the adult blood system, was previously thought to derive from the extra-embryonic yolk sac. However, there is now considerable evidence that in both avian and murine systems, yolk sac hematopoietic cells are largely a transient, embryonic population and the definitive stem cell, in fact, derives from a distinct region within the embryonic mesoderm, the aorta-gonad-mesonephros region. In the human embryo, an analogous region has been found to contain a cluster of cells distinct from, but closely associated with, the ventral endothelium of the dorsal aorta, the appearance of which is restricted both spatially and temporally. We have used antibodies recognising hematopoietic regulatory factors to further characterise this region in the human embryo. These studies indicate that all factors examined, including vascular endothelial growth factor and its receptor FLK-1, Flt-3 ligand and its receptor STK-1, and stem cell leukemia transcription factor, are expressed by both hematopoietic cells in the cluster and endothelial cells. However, there is some discontinuity in cells directly underlying the cluster. Furthermore, we have identified a morphologically distinct region of densely-packed, rounded cells in the mesenchyme directly beneath the ventral wall of the dorsal aorta, and running along its entire length. In the preumbilical AGM region, directly underlying the hematopoietic cluster, but not at more rostral and caudal levels, this region of mesenchyme expresses tenascin-C, an extracellular matrix glycoprotein known to facilitate cell-cell interactions and migration. This region of cells may therefore provide the microenvironmental support for the intraembryonic development of definitive hematopoietic stem cells, a process in which tenascin-C may play a pivotal role.  (+info)

Endogenous galectins and effect of galectin hapten inhibitors on the differentiation of the chick mesonephros. (6/184)

Galectins are galactoside-binding lectins. In the mesonephros of the chick embryo, the 16-kDa galectin is abundant in the glomerular and tubular basement membranes where it colocalizes with fibronectin and laminin. To test whether galectin-glycoprotein interactions could play a role in mesonephric development, the effects of the galectin hapten inhibitors thiodigalactoside (TDG) and lactose on the differentiation of the cultured mesonephros were investigated. When compared to control saccharide-free or maltose-treated cultures, mesonephroi cultured in the presence of TDG and lactose exhibited defects in tissue organization. These included a distorted tubule shape, pseudo-stratification of the tubular epithelium, and detachment of glomerular podocytes from the basement membrane. The presence of molecular differentiation markers in the developing mesonephros was investigated. In vivo, expression of the epithelial-specific cell adhesion molecule E-cadherin is restricted to differentiated tubular epithelial cells, whereas the intermediate filament protein vimentin is present in mesonephrogenic mesenchyme and is undetectable in tubular epithelial cells. In mesonephroi cultured in the absence of sugars or in the presence of maltose, the expression pattern of these two marker molecules resembles that found in the mesonephros in vivo. In contrast, in the mesonephroi cultured in the presence of TDG and lactose, the epithelial tubular cells expressing E-cadherin also express vimentin. Re-expression of vimentin in the tubular epithelial cells could indicate a partial reversal to a mesenchymal phenotype. Results suggest that galectin-glycoprotein interactions in the basement membrane are important in the maintenance of the renal epithelial phenotype. Dev Dyn 1999;215:248-263.  (+info)

Stem cell emergence and hemopoietic activity are incompatible in mouse intraembryonic sites. (7/184)

In the mouse embryo, the generation of candidate progenitors for long-lasting hemopoiesis has been reported in the paraaortic splanchnopleura (P-Sp)/ aorta-gonad-mesonephros (AGM) region. Here, we address the following question: can the P-Sp/AGM environment support hemopoietic differentiation as well as generate stem cells, and, conversely, are other sites where hemopoietic differentiation occurs capable of generating stem cells? Although P-Sp/AGM generates de novo hemopoietic stem cells between 9.5 and 12.5 days post coitus (dpc), we show here that it does not support hemopoietic differentiation. Among mesoderm-derived sites, spleen and omentum were shown to be colonized by exogenous cells in the same fashion as the fetal liver. Cells colonizing the spleen were multipotent and pursued their evolution to committed progenitors in this organ. In contrast, the omentum, which was colonized by lymphoid-committed progenitors that did not expand, cannot be considered as a hemopoietic organ. From these data, stem cell generation appears incompatible with hemopoietic activity. At the peak of hemopoietic progenitor production in the P-Sp/AGM, between 10.5 and 11.5 dpc, multipotent cells were found at the exceptional frequency of 1 out of 12 total cells and 1 out of 4 AA4.1+ cells. Thus, progenitors within this region constitute a pool of undifferentiated hemopoietic cells readily accessible for characterization.  (+info)

Hematopoietic cells in cultures of the murine embryonic aorta-gonad-mesonephros region are induced by c-Myb. (8/184)

Definitive hematopoiesis begins in the para-aortic, splanchnopleural (P-Sp) and aorta-gonad-mesonephros (AGM) regions of mouse embryos and then switches to the fetal liver [1] [2] [3]. Gene-targeted mice lacking the c-Myb transcription factor have severe hematopoietic defects in the fetal liver [4]. The role of c-Myb, if any, in P-Sp/AGM hematopoiesis has not been examined, however. Recently, we reported that oncostatin M can effectively expand both hematopoietic and endothelial-like cells from in vitro cultures of the AGM region [5]. Using this cell culture system, we examined the involvement of c-Myb in definitive hematopoiesis in the P-Sp and AGM regions. When primary cultures from the P-Sp or AGM regions of wild-type mouse embryos were probed with an anti-c-Myb antibody, hematopoietic cells but not endothelial-like cells showed positive staining. In contrast, in the P-Sp/AGM culture from c-myb(-/-) embryos, no hematopoietic cells were generated and endothelial-like cells predominated, indicating that the impairment of hematopoiesis in the liver of c-myb(-/-) embryos is actually preceded by a defect in P-Sp/AGM hematopoiesis. Hematogenic precursor cells were, however, still present in an inert but competent form among the endothelial-like, adherent cell population of c-myb(-/-) P-Sp/AGM cultures. When infected with a retrovirus carrying c-myb cDNA, these cultures gave rise to a significant number of hematopoietic cells. The rescued cells, unlike wild-type hematopoietic cells, were negative for c-Kit (a marker of hematopoietic progenitors), but did express other hematopoietic cell surface markers such as Mac-1, Gr-1 (myeloid markers), CD19, B220, Thy-1.2 (Iymphoid markers), and Ter119 (an erythroid marker). Thus, c-Myb plays a role in the generation of hematopoietic cells in the embryonic P-Sp and AGM regions.  (+info)

Mesonephros is defined as the intermediate part of the embryonic excretory system in higher vertebrates, which develops into the permanent kidney in some lower vertebrates. In humans, it represents the transitory kidney that functions during early fetal life and gives rise to the male reproductive structures (i.e., epididymis, vas deferens, and efferent ductules) after its excretory function is taken over by the metanephros or permanent kidney. The mesonephros consists of a number of tubules called mesonephric tubules, which open into the mesonephric (Wolffian) duct, and a network of blood vessels known as the mesonephric capillaries or glomeruli.

Gonads are the reproductive organs that produce gametes (sex cells) and sex hormones. In males, the gonads are the testes, which produce sperm and testosterone. In females, the gonads are the ovaries, which produce eggs and estrogen and progesterone. The development, function, and regulation of the gonads are crucial for reproductive health and fertility.

The Wolffian ducts, also known as the mesonephric ducts, are a pair of embryological structures present in the developing urinary system of male fetuses. They originate from the intermediate mesoderm and descend towards the posterior end of the developing kidney, or the metanephros.

The Wolffian ducts play a crucial role in the formation of the male reproductive system. In males, these ducts give rise to the vas deferens, seminal vesicles, and ejaculatory ducts. They also contribute to the development of the kidneys, specifically the pronephros and mesonephros, which are transient structures that eventually give way to the permanent kidney, or metanephros.

In females, the Wolffian ducts regress due to the absence of testicular hormones, as they do not contribute to the formation of female reproductive organs. Instead, the paramesonephric ducts, also known as the Mullerian ducts, develop into the female reproductive structures such as the fallopian tubes, uterus, and vagina.

The urogenital system is a part of the human body that includes the urinary and genital systems. The urinary system consists of the kidneys, ureters, bladder, and urethra, which work together to produce, store, and eliminate urine. On the other hand, the genital system, also known as the reproductive system, is responsible for the production, development, and reproduction of offspring. In males, this includes the testes, epididymis, vas deferens, seminal vesicles, prostate gland, bulbourethral glands, and penis. In females, it includes the ovaries, fallopian tubes, uterus, vagina, mammary glands, and external genitalia.

The urogenital system is closely related anatomically and functionally. For example, in males, the urethra serves as a shared conduit for both urine and semen, while in females, the urethra and vagina are separate but adjacent structures. Additionally, some organs, such as the prostate gland in males and the Skene's glands in females, have functions that overlap between the urinary and genital systems.

Disorders of the urogenital system can affect both the urinary and reproductive functions, leading to a range of symptoms such as pain, discomfort, infection, and difficulty with urination or sexual activity. Proper care and maintenance of the urogenital system are essential for overall health and well-being.

I believe there may be some confusion in your question. "Quail" is typically used to refer to a group of small birds that belong to the family Phasianidae and the subfamily Perdicinae. There is no established medical definition for "quail."

However, if you're referring to the verb "to quail," it means to shrink back, draw back, or cower, often due to fear or intimidation. In a medical context, this term could be used metaphorically to describe a patient's psychological response to a threatening situation, such as receiving a difficult diagnosis. But again, "quail" itself is not a medical term.

"Sex differentiation" is a term used in the field of medicine, specifically in reproductive endocrinology and genetics. It refers to the biological development of sexual characteristics that distinguish males from females. This process is regulated by hormones and genetic factors.

There are two main stages of sex differentiation: genetic sex determination and gonadal sex differentiation. Genetic sex determination occurs at fertilization, where the combination of X and Y chromosomes determines the sex of the individual (typically, XX = female and XY = male). Gonadal sex differentiation then takes place during fetal development, where the genetic sex signals the development of either ovaries or testes.

Once the gonads are formed, they produce hormones that drive further sexual differentiation, leading to the development of internal reproductive structures (such as the uterus and fallopian tubes in females, and the vas deferens and seminal vesicles in males) and external genitalia.

It's important to note that while sex differentiation is typically categorized as male or female, there are individuals who may have variations in their sexual development, leading to intersex conditions. These variations can occur at any stage of the sex differentiation process and can result in a range of physical characteristics that do not fit neatly into male or female categories.

Para-aortic bodies, also known as autonomic ganglia or para-aortic chains, are clusters of nerve cells (ganglia) located near the aorta, the largest artery in the body. These ganglia are part of the autonomic nervous system, which controls involuntary bodily functions such as heart rate, digestion, and respiratory rate.

The para-aortic bodies are primarily responsible for regulating the function of the organs in the abdomen and pelvis. They receive input from sensory neurons and send output to effector organs through a complex network of nerves. The neurotransmitters acetylcholine and noradrenaline are released at these ganglia to mediate the transmission of signals between nerve cells.

These structures can be important in the diagnosis and treatment of certain medical conditions, such as neuroblastoma, a type of cancer that arises from immature nerve cells in infants and children. In some cases, surgical removal of para-aortic bodies may be necessary to treat this condition.

The allantois is a fetal membranous structure in mammals, including humans, that arises from the posterior end of the embryonic hindgut during early development. It plays an essential role in the exchange of waste products and nutrients between the developing fetus and the mother's uterus.

The allantois serves as a reservoir for urinary waste produced by the fetal kidneys, which are the primitive metanephros at this stage. As the allantois grows, it extends toward the chorion, another fetal membrane lining the uterine wall. The point where these two structures meet forms the allantoic bud, which eventually develops into the umbilical cord.

In some non-mammalian vertebrates, like birds and reptiles, the allantois plays a significant role in gas exchange and calcium transport for eggshell formation. However, in humans and other mammals, its primary function is to form part of the umbilical cord, which connects the developing fetus to the placenta, allowing for nutrient and waste exchange between the mother and the fetus.

After birth, the remnants of the allantois become a small fibrous structure called the urachus or median umbilical ligament, which extends from the bladder to the umbilicus. This structure usually obliterates during infancy but may persist as a variant anatomical feature in some individuals.

A chick embryo refers to the developing organism that arises from a fertilized chicken egg. It is often used as a model system in biological research, particularly during the stages of development when many of its organs and systems are forming and can be easily observed and manipulated. The study of chick embryos has contributed significantly to our understanding of various aspects of developmental biology, including gastrulation, neurulation, organogenesis, and pattern formation. Researchers may use various techniques to observe and manipulate the chick embryo, such as surgical alterations, cell labeling, and exposure to drugs or other agents.

The Sex-Determining Region Y (SRY) protein is a transcription factor that plays a critical role in male sex determination. It is encoded by the SRY gene, which is located on the Y chromosome in humans and many other mammal species. The primary function of the SRY protein is to initiate the development of the testes during embryonic development.

In the absence of a functional SRY protein, the gonads will develop into ovaries. With a functional SRY protein, the gonads will develop into testes, which then produce androgens, including testosterone, that are necessary for the development of male secondary sexual characteristics. Mutations in the SRY gene can lead to sex reversal, where an individual with a Y chromosome develops as a female due to non-functional or absent SRY protein.

The testis, also known as the testicle, is a male reproductive organ that is part of the endocrine system. It is located in the scrotum, outside of the abdominal cavity. The main function of the testis is to produce sperm and testosterone, the primary male sex hormone.

The testis is composed of many tiny tubules called seminiferous tubules, where sperm are produced. These tubules are surrounded by a network of blood vessels, nerves, and supportive tissues. The sperm then travel through a series of ducts to the epididymis, where they mature and become capable of fertilization.

Testosterone is produced in the Leydig cells, which are located in the interstitial tissue between the seminiferous tubules. Testosterone plays a crucial role in the development and maintenance of male secondary sexual characteristics, such as facial hair, deep voice, and muscle mass. It also supports sperm production and sexual function.

Abnormalities in testicular function can lead to infertility, hormonal imbalances, and other health problems. Regular self-examinations and medical check-ups are recommended for early detection and treatment of any potential issues.

Organ culture techniques refer to the methods used to maintain or grow intact organs or pieces of organs under controlled conditions in vitro, while preserving their structural and functional characteristics. These techniques are widely used in biomedical research to study organ physiology, pathophysiology, drug development, and toxicity testing.

Organ culture can be performed using a variety of methods, including:

1. Static organ culture: In this method, the organs or tissue pieces are placed on a porous support in a culture dish and maintained in a nutrient-rich medium. The medium is replaced periodically to ensure adequate nutrition and removal of waste products.
2. Perfusion organ culture: This method involves perfusing the organ with nutrient-rich media, allowing for better distribution of nutrients and oxygen throughout the tissue. This technique is particularly useful for studying larger organs such as the liver or kidney.
3. Microfluidic organ culture: In this approach, microfluidic devices are used to create a controlled microenvironment for organ cultures. These devices allow for precise control over the flow of nutrients and waste products, as well as the application of mechanical forces.

Organ culture techniques can be used to study various aspects of organ function, including metabolism, secretion, and response to drugs or toxins. Additionally, these methods can be used to generate three-dimensional tissue models that better recapitulate the structure and function of intact organs compared to traditional two-dimensional cell cultures.

In medical and embryological terms, the mesoderm is one of the three primary germ layers in the very early stages of embryonic development. It forms between the ectoderm and endoderm during gastrulation, and it gives rise to a wide variety of cell types, tissues, and organs in the developing embryo.

The mesoderm contributes to the formation of structures such as:

1. The connective tissues (including tendons, ligaments, and most of the bones)
2. Muscular system (skeletal, smooth, and cardiac muscles)
3. Circulatory system (heart, blood vessels, and blood cells)
4. Excretory system (kidneys and associated structures)
5. Reproductive system (gonads, including ovaries and testes)
6. Dermis of the skin
7. Parts of the eye and inner ear
8. Several organs in the urogenital system

Dysfunctions or abnormalities in mesoderm development can lead to various congenital disorders and birth defects, highlighting its importance during embryogenesis.

In situ hybridization (ISH) is a molecular biology technique used to detect and localize specific nucleic acid sequences, such as DNA or RNA, within cells or tissues. This technique involves the use of a labeled probe that is complementary to the target nucleic acid sequence. The probe can be labeled with various types of markers, including radioisotopes, fluorescent dyes, or enzymes.

During the ISH procedure, the labeled probe is hybridized to the target nucleic acid sequence in situ, meaning that the hybridization occurs within the intact cells or tissues. After washing away unbound probe, the location of the labeled probe can be visualized using various methods depending on the type of label used.

In situ hybridization has a wide range of applications in both research and diagnostic settings, including the detection of gene expression patterns, identification of viral infections, and diagnosis of genetic disorders.

The term "extremities" in a medical context refers to the most distant parts of the body, including the hands and feet (both fingers and toes), as well as the arms and legs. These are the farthest parts from the torso and head. Medical professionals may examine a patient's extremities for various reasons, such as checking circulation, assessing nerve function, or looking for injuries or abnormalities.

Developmental gene expression regulation refers to the processes that control the activation or repression of specific genes during embryonic and fetal development. These regulatory mechanisms ensure that genes are expressed at the right time, in the right cells, and at appropriate levels to guide proper growth, differentiation, and morphogenesis of an organism.

Developmental gene expression regulation is a complex and dynamic process involving various molecular players, such as transcription factors, chromatin modifiers, non-coding RNAs, and signaling molecules. These regulators can interact with cis-regulatory elements, like enhancers and promoters, to fine-tune the spatiotemporal patterns of gene expression during development.

Dysregulation of developmental gene expression can lead to various congenital disorders and developmental abnormalities. Therefore, understanding the principles and mechanisms governing developmental gene expression regulation is crucial for uncovering the etiology of developmental diseases and devising potential therapeutic strategies.

Embryonic and fetal development is the process of growth and development that occurs from fertilization of the egg (conception) to birth. The terms "embryo" and "fetus" are used to describe different stages of this development:

* Embryonic development: This stage begins at fertilization and continues until the end of the 8th week of pregnancy. During this time, the fertilized egg (zygote) divides and forms a blastocyst, which implants in the uterus and begins to develop into a complex structure called an embryo. The embryo consists of three layers of cells that will eventually form all of the organs and tissues of the body. During this stage, the basic structures of the body, including the nervous system, heart, and gastrointestinal tract, begin to form.
* Fetal development: This stage begins at the end of the 8th week of pregnancy and continues until birth. During this time, the embryo is called a fetus, and it grows and develops rapidly. The organs and tissues that were formed during the embryonic stage continue to mature and become more complex. The fetus also begins to move and kick, and it can hear and respond to sounds from outside the womb.

Overall, embryonic and fetal development is a complex and highly regulated process that involves the coordinated growth and differentiation of cells and tissues. It is a critical period of development that lays the foundation for the health and well-being of the individual throughout their life.

Morphogenesis is a term used in developmental biology and refers to the process by which cells give rise to tissues and organs with specific shapes, structures, and patterns during embryonic development. This process involves complex interactions between genes, cells, and the extracellular environment that result in the coordinated movement and differentiation of cells into specialized functional units.

Morphogenesis is a dynamic and highly regulated process that involves several mechanisms, including cell proliferation, death, migration, adhesion, and differentiation. These processes are controlled by genetic programs and signaling pathways that respond to environmental cues and regulate the behavior of individual cells within a developing tissue or organ.

The study of morphogenesis is important for understanding how complex biological structures form during development and how these processes can go awry in disease states such as cancer, birth defects, and degenerative disorders.

Scanning electron microscopy (SEM) is a type of electron microscopy that uses a focused beam of electrons to scan the surface of a sample and produce a high-resolution image. In SEM, a beam of electrons is scanned across the surface of a specimen, and secondary electrons are emitted from the sample due to interactions between the electrons and the atoms in the sample. These secondary electrons are then detected by a detector and used to create an image of the sample's surface topography. SEM can provide detailed images of the surface of a wide range of materials, including metals, polymers, ceramics, and biological samples. It is commonly used in materials science, biology, and electronics for the examination and analysis of surfaces at the micro- and nanoscale.

An ovary is a part of the female reproductive system in which ova or eggs are produced through the process of oogenesis. They are a pair of solid, almond-shaped structures located one on each side of the uterus within the pelvic cavity. Each ovary measures about 3 to 5 centimeters in length and weighs around 14 grams.

The ovaries have two main functions: endocrine (hormonal) function and reproductive function. They produce and release eggs (ovulation) responsible for potential fertilization and development of an embryo/fetus during pregnancy. Additionally, they are essential in the production of female sex hormones, primarily estrogen and progesterone, which regulate menstrual cycles, sexual development, and reproduction.

During each menstrual cycle, a mature egg is released from one of the ovaries into the fallopian tube, where it may be fertilized by sperm. If not fertilized, the egg, along with the uterine lining, will be shed, leading to menstruation.

A kidney, in medical terms, is one of two bean-shaped organs located in the lower back region of the body. They are essential for maintaining homeostasis within the body by performing several crucial functions such as:

1. Regulation of water and electrolyte balance: Kidneys help regulate the amount of water and various electrolytes like sodium, potassium, and calcium in the bloodstream to maintain a stable internal environment.

2. Excretion of waste products: They filter waste products from the blood, including urea (a byproduct of protein metabolism), creatinine (a breakdown product of muscle tissue), and other harmful substances that result from normal cellular functions or external sources like medications and toxins.

3. Endocrine function: Kidneys produce several hormones with important roles in the body, such as erythropoietin (stimulates red blood cell production), renin (regulates blood pressure), and calcitriol (activated form of vitamin D that helps regulate calcium homeostasis).

4. pH balance regulation: Kidneys maintain the proper acid-base balance in the body by excreting either hydrogen ions or bicarbonate ions, depending on whether the blood is too acidic or too alkaline.

5. Blood pressure control: The kidneys play a significant role in regulating blood pressure through the renin-angiotensin-aldosterone system (RAAS), which constricts blood vessels and promotes sodium and water retention to increase blood volume and, consequently, blood pressure.

Anatomically, each kidney is approximately 10-12 cm long, 5-7 cm wide, and 3 cm thick, with a weight of about 120-170 grams. They are surrounded by a protective layer of fat and connected to the urinary system through the renal pelvis, ureters, bladder, and urethra.

Inguinal hernia, also known as an inguinal rupture or groin hernia, is a protrusion of abdominal-cavity contents through the inguinal canal. The inguinal canal is a passage in the lower abdominal wall that carries the spermatic cord in males and a round ligament in females. Inguinal hernias are more common in men than women.

There are two types of inguinal hernias: direct and indirect. Direct inguinal hernias occur when the abdominal lining and/or fat push through a weakened area in the lower abdominal wall, while indirect inguinal hernias result from a congenital condition where the abdominal lining and/or fat protrude through the internal inguinal ring, a normal opening in the abdominal wall.

Inguinal hernias can cause discomfort or pain, especially during physical activities, coughing, sneezing, or straining. In some cases, incarceration or strangulation of the hernia may occur, leading to serious complications such as bowel obstruction or tissue necrosis, which require immediate medical attention.

Surgical repair is the standard treatment for inguinal hernias, and it can be performed through open or laparoscopic techniques. The goal of surgery is to return the protruding tissues to their proper position and strengthen the weakened abdominal wall with sutures or mesh reinforcement.

I believe there might be a bit of confusion in your question. A "history" in medical terms usually refers to the detailed account of a patient's symptoms, illnesses, and treatments over time. It is a crucial part of the medical record and helps healthcare professionals understand the patient's health status and inform their care plans.

On the other hand, "16th century" refers to a specific period in history, spanning from 1501 to 1600 AD.

There isn't a direct medical definition for 'History, 16th Century.' However, if you are interested in learning about the medical advancements and practices during that time, I would be happy to provide some information. The 16th century was marked by significant developments in anatomy, surgery, and pharmacology, thanks to pioneers like Andreas Vesalius, Ambroise Paré, and William Shakespeare, who incorporated medical themes into his plays.

A hernia is a protrusion of an organ or tissue through a weakened area in the abdominal wall, often appearing as a bulge beneath the skin. This condition can occur in various parts of the body such as the groin (inguinal hernia), navel (umbilical hernia), or site of a previous surgical incision (incisional hernia). Hernias may cause discomfort or pain, especially when straining, lifting heavy objects, or during bowel movements. In some cases, they may lead to serious complications like intestinal obstruction or strangulation, requiring immediate medical attention.

A diaphragmatic hernia is a type of hernia that occurs when the abdominal organs (such as the stomach, intestines, or liver) protrude through an opening in the diaphragm, the thin muscle that separates the chest and abdominal cavities. This condition can be present at birth (congenital) or acquired due to injury or surgery.

There are two main types of diaphragmatic hernias:

1. Bochdalek hernia: This is a congenital defect that occurs when the posterior portion of the diaphragm fails to close properly during fetal development, creating an opening through which abdominal organs can move into the chest cavity. It is more common on the left side and can lead to pulmonary hypoplasia (underdevelopment of the lungs) and other complications if not detected and treated early.
2. Morgagni hernia: This is a less common type of congenital diaphragmatic hernia that occurs when there is an opening in the anterior portion of the diaphragm, allowing abdominal organs to move into the chest cavity near the sternum. It tends to be asymptomatic and may not be discovered until adulthood.

Acquired diaphragmatic hernias can result from trauma, such as a car accident or penetrating injury, which causes a tear in the diaphragm. In some cases, surgical procedures involving the abdomen or chest can also lead to a diaphragmatic hernia.

Symptoms of a diaphragmatic hernia may include difficulty breathing, chest pain, vomiting, and bowel obstruction. Treatment typically involves surgery to repair the defect in the diaphragm and return the abdominal organs to their proper position.

A ventral hernia is a type of hernia that occurs in the abdominal wall, specifically in the anterior (front) aspect. It can occur due to a weakness or defect in the abdominal wall muscles and fascia, which allows the internal organs or tissues to push through and create a bulge or swelling.

Ventral hernias can be classified into several types based on their location, size, and cause. Some of the common types include:

1. Incisional Hernia - occurs at the site of a previous surgical incision, where the abdominal wall has not healed properly or has become weakened over time.
2. Epigastric Hernia - located in the upper middle part of the abdomen, between the breastbone and the navel.
3. Umbilical Hernia - occurs around the belly button, most commonly seen in infants but can also affect adults.
4. Spigelian Hernia - a rare type of hernia that occurs lateral to the rectus sheath, usually at the level of the semilunar line.
5. Diastasis Recti - a separation of the abdominal muscles in the midline, which can lead to a ventral hernia if not treated.

Symptoms of a ventral hernia may include pain or discomfort, especially when lifting heavy objects, straining, coughing, or during physical activity. In some cases, a hernia may become incarcerated or strangulated, which requires immediate medical attention. Treatment options for ventral hernias typically involve surgical repair, either through open surgery or laparoscopic techniques.

An abdominal hernia refers to the protrusion of an organ or tissue through a weakened area in the abdominal wall, resulting in a bulge. This condition can occur due to various factors such as congenital defects, aging, obesity, pregnancy, persistent coughing, or previous surgeries that have left behind weak spots in the abdominal wall.

There are several types of abdominal hernias, including:

1. Inguinal Hernia: This is the most common type of hernia, occurring when the intestine or bladder protrudes through the inguinal canal in the lower abdomen. Inguinal hernias are more prevalent in men than women.
2. Femoral Hernia: This type of hernia occurs when the intestine or fatty tissue pushes through a weakened area near the femoral artery, located in the upper thigh region. Femoral hernias are more common in women, especially those who are pregnant or obese.
3. Incisional Hernia: This type of hernia develops at the site of a previous abdominal surgery where the abdominal muscles have weakened or failed to heal properly.
4. Umbilical Hernia: An umbilical hernia occurs when the intestine protrudes through the abdominal wall near the navel, often visible as a bulge around the belly button. This type of hernia is more common in infants but can also affect adults, particularly those who are overweight or have had multiple pregnancies.
5. Epigastric Hernia: An epigastric hernia occurs when fatty tissue protrudes through a weakened area between the breastbone and the navel. These hernias are usually small and often painless but can cause discomfort or complications if they become incarcerated or strangulated.

Abdominal hernias can vary in size, from small and barely noticeable to large and severely painful. Symptoms may include a visible bulge, localized pain or discomfort, especially when lifting heavy objects, coughing, or straining during bowel movements. In some cases, hernias may become incarcerated (trapped) or strangulated (blood supply is cut off), which can lead to severe pain, nausea, vomiting, and require immediate medical attention.

Treatment for abdominal hernias typically involves surgical repair, either through open surgery or laparoscopic techniques. The choice of procedure depends on various factors, including the size and location of the hernia, the patient's overall health, and their personal preferences. In some cases, watchful waiting may be recommended for small, asymptomatic hernias, but it is essential to consult with a healthcare professional to determine the best course of action.

A femoral hernia is a type of hernia that occurs when a portion of the abdominal wall tissue or intestine protrudes through a weakened area in the lower part of the abdominal wall, specifically at the opening of the femoral canal. This canal is located near the groin region and contains blood vessels that pass from the abdomen to the leg.

Femoral hernias are more common in women than men, particularly those who are pregnant, obese, or have a history of multiple pregnancies. Symptoms may include a visible bulge in the inner thigh or groin area, especially when standing, coughing, or straining. Pain or discomfort in the lower abdomen or groin region, particularly during physical activities, is also common.

While some femoral hernias may not cause any symptoms and can be left untreated, they have a higher risk of becoming incarcerated or strangulated compared to other types of hernias. Incarceration occurs when the protruding tissue becomes trapped and cannot be pushed back in, while strangulation happens when the blood supply to the trapped tissue is cut off, leading to tissue death if not treated promptly with surgery.

The Wolffian body is composed of: mesonephros + paramesonephrotic blastema) The mesonephros acts as a structure similar to the ... The tubules collectively constitute the mesonephros.[citation needed] The mesonephros as a whole produces urine from the 6th ... In humans, the mesonephros consists of units which are similar in structure and function to nephrons of the adult kidney. Each ... The mesonephros (Greek: middle kidney) is one of three excretory organs that develop in vertebrates. It serves as the main ...
The mesonephros go on to form nephrons and other associated structures of the kidneys. The formation of the AGM region has been ... The aorta-gonad-mesonephros (AGM) is a region of embryonic mesoderm that develops during embryonic development from the para- ... LTR-HSC activity was also found in the aorta gonad mesonephros region at a slightly earlier time than in the yolk sac and fetal ... The aorta gonad mesonephros region has been shown to harbour multipotent hematopoietic colony-forming unit-spleen (CFU-S) ...
Mesonephros develops after the pronephros, replacing it. The mesonephros is the final kidney in amphibians and most fish. In ... Nephrostomes are typically absent in the embryonic mesonephros of birds and mammals. Mesonephros in fish has the ability to add ... after which the mesonephros develops. The mesonephros probably appeared in the course of evolution in response to the increase ... from which both the mesonephros and metanephros are developed in the embryo of amniotes. Unlike the pronephros, the mesonephros ...
The tubules collectively constitute the mesonephros. The mesonephros persists and form the permanent kidneys in fish and ... Some of the tubules of the mesonephros form part of the permanent kidney. In the outer part of the intermediate mesoderm, ... The renal tubules of the metanephros, unlike those of the pronephros and mesonephros, do not open into the Wolffian duct. ... These embryonic structures are on either side; the pronephros, the mesonephros and the metanephros of the kidney, and the ...
... the term mesonephros is usually reserved for the embryonic kidney of amniotes. The mesonephros and metanephros of amniotes are ... mesonephros', but the opisthonephros in anamniotes (lampreys, fish, and amphibians) differ considerably than the mesonephros in ... Pronephros Mesonephros Metanephros Juneja, Kavita (January 2002). Animal Physiology (1st ed.). Anmol Publications. ISBN 81-261- ... It is formed from the extended mesonephros along with tubules from the posterior nephric ridge. The functional embryonic kidney ...
In males, the mesonephros releases retinoic acid. RA then goes to the gonad causing an enzyme called CYP26B1 to be released by ... In females, the mesonephros releases RA, which enters the gonad. RA stimulates Stra8, a critical gatekeeper of meiosis (1), and ...
In the majority of vertebrates, the mesonephros persists into the adult, albeit usually fused with the more advanced ... mesonephros, and metanephros. The metanephros are primordia of the permanent kidney. The kidneys excrete a variety of waste ... metanephros; only in amniotes is the mesonephros restricted to the embryo. The kidneys of fish and amphibians are typically ...
... are genital ridges that are next to the mesonephros. In males, some of the mesonephric kidney tubules, ...
Kidney disease and also affections of the renal pelvis and mesonephros. "Traumatische Leukämie," in "Deutsche Med. ...
It is named after Caspar Friedrich Wolff who described the mesonephros and its ducts in his dissertation in 1759. Diagram of a ... The mesonephric duct connects the primitive kidney, the mesonephros, to the cloaca. It also serves as the primordium for male ...
In the male toad, the Bidder's organ is beneath the mesentery of the intestine, between the two mesonephroi. It is a ... or mesonephros. It is formed at the cranial tip of the male and female gonad during the larval stage. Its main function appears ...
... the mesonephros. The paramesonephric ducts are formed by the craniocaudal invagination of a ribbon of thickened coelomic ...
The urogenital ridge is made up of the gonadal anlage and the mesonephros. The mesonephros is involved in the development of ... This is indicated by the absence of SRY expression in the mesonephros. SRY expression is expressed exclusively in the ...
Some of the tubules of the mesonephros form part of the permanent kidney. Disorders of the genitourinary system includes a ... These embryonic structures are on either side: the pronephros, the mesonephros and the metanephros of the kidney, and the ... The pronephros disappears very early; the structural elements of the mesonephros mostly degenerate, but the gonad is developed ...
2004). "Spred-2 suppresses aorta-gonad-mesonephros hematopoiesis by inhibiting MAP kinase activation". J. Exp. Med. 199 (5): ...
The mammalian mesonephros is similar to the kidneys of aquatic amphibians and fishes. During the fifth week of gestation, the ... mesonephros, and metanephros. The pronephros is the most immature form of kidney, while the metanephros is most developed. The ...
It has been suggested that Sertoli cells may derive from the fetal mesonephros. After puberty, Sertoli cells begin to elongate ...
Zamboni, L.; Bezard, J.; Mauleon, P. (1979). "The role of the mesonephros in the development of the sheep fetal ovary". Annales ... Upadhyay S, Zamboni L (1982). "Preliminary observations on the role of the mesonephros in the development of the adrenal cortex ...
... to the mesonephros. From the front of the mesonephros a fold of peritoneum termed the inguinal fold grows forward to meet and ... At first, the mesonephros and gonadal ridge are continuous, but as the embryo grows the gonadal ridge gradually becomes pinched ... The ovary is thus formed mainly from the genital ridge and partly from the mesonephros. Later the mass is differentiated into a ... The testis is developed in much the same way as the ovary, originating from mesothelium as well as mesonephros. Like the ovary ...
The suspensory ligament originates from the mesonephros, which, in turn, originates from intermediate mesoderm. The prenatal ...
The mesonephros derives from intermediate mesoderm in the upper thoracic to upper lumbar segments. Excretory tubules are formed ... Three different kidney systems form in the developing embryo: the pronephros, the mesonephros and the metanephros. Only the ... Embryo loss Aorta-gonad-mesonephros CDX2 Developmental biology Drosophila embryogenesis Embryomics Human tooth development List ...
The very first hematopoietic stem cells during (mouse and human) embryonic development are found in aorta-gonad-mesonephros ... In mammalian embryology, the first definitive Hematopoietic stem cells are detected in the AGM (aorta-gonad-mesonephros), and ... aorta-gonad-mesonephros region, through a process known as endothelial-to-hematopoietic transition. In adults, haematopoiesis ... "Highly potent human hematopoietic stem cells first emerge in the intraembryonic aorta-gonad-mesonephros region". The Journal of ...
Maturation continues as the medial aspect of each mesonephros grows to form the genital ridge. The genital ridge continues to ...
Hematopoiesis also takes place in many other tissues or organs such as the yolk sac, the aorta-gonad mesonephros (AGM) region, ... The formation of these cells occurs in the AGM (aorta-gonad-mesonephros) later in development. This occurs by conversion of ...
Subsequently, the mesonephros degrades in females, and in males it participates in the development of the reproductive system. ... Then, caudal to the pronephros, the mesonephros develops, which is the functioning kidney of the embryo. ... mesonephros and metanephros. All three types develop from the intermediate mesoderm sequentially in the cranio-caudal direction ...
He was the discoverer of the primitive kidneys (mesonephros), or "Wolffian bodies" and its excretory ducts. He described these ... Wolffian ducts or mesonephric ducts Wolffian cysts Wolffian body or mesonephros Wolff's islands or blood islands William A. ...
... mesonephros and metanephros respectively (anamniote embryos form only a pronephros and mesonephros). The intermediate mesoderm ... The mesonephros is constituted of a set of new tubules formed from the lateral and ventral sides of the gonadal ridge joining ... The mesonephros functions between the 6th and 10th weeks of embryological life of mammals as a temporary kidney, but serves as ... Despite its transiency, the mesonephros is crucial for the development of structures such as the Wolffian duct (or mesonephric ...
In the embryo, the epididymis develops from tissue that once formed the mesonephros, a primitive kidney found in many aquatic ...
The 1st phase is the pronephros, the 2nd phase is the mesonephros and the 3rd and final stage is the metanephros. Singh, ...
The male germ cells are protected from external signalling, like retinoic acid from the mesonephros, by the Leydig and Sertoli ... excreted by the mesonephros. Retinoic acid is the major factor in meiosis, upregulating genes including ''Stra8'', ''Dmc1'' and ...
It is succeeded by the mesonephros, which in fish and amphibians remains as the adult kidney. In amniotes, the mesonephros is ... In human beings, it is rudimentary, appears at the end of the third week (day 20) and replaced by mesonephros after 3.5 weeks. ... The duct of the mesonephros forms the Wolffian duct and ureter of the adult kidney. The embryonic kidney and its derivatives ... Mesonephros Metanephros Development of the pronephros in zebrafish[permanent dead link] (Articles with short description, Short ...
A large part of the head end of the mesonephros atrophies and disappears; of the remainder the anterior tubules form the ... Via the rete testis, the seminiferous tubules become connected with outgrowths from the mesonephros, which form the efferent ...
They are similar to the mesonephros of higher vertebrates (reptiles, birds, and mammals). The kidneys contain clusters of ...
... aorta-gonad-mesonephros (AGM) and the umbilical and vitelline arteries. HSPCs are generated via the hemogenic endothelium, a ...
At five to six weeks of gestation, the Mesonephros differentiates into a tissue known as the gonadal ridge. The gonadal ridge ... Cells that will become adrenal tissue move Retroperitoneally to the upper portion of the Mesonephros. At seven weeks of ...
At five to six weeks of gestation, the mesonephros differentiates into a tissue known as the genital ridge. The genital ridge ... Cells that will become adrenal tissue move retroperitoneally to the upper portion of the mesonephros. At seven weeks of ...
The Wolffian body is composed of: mesonephros + paramesonephrotic blastema) The mesonephros acts as a structure similar to the ... The tubules collectively constitute the mesonephros.[citation needed] The mesonephros as a whole produces urine from the 6th ... In humans, the mesonephros consists of units which are similar in structure and function to nephrons of the adult kidney. Each ... The mesonephros (Greek: middle kidney) is one of three excretory organs that develop in vertebrates. It serves as the main ...
Mesonephros / pathology* * Mullerian Ducts / pathology* * Neoplasm Staging * PAX2 Transcription Factor / metabolism* * ...
A large part of the head end of the mesonephros atrophies and disappears; of the remainder the anterior tubules form the ... Via the rete testis, the seminiferous tubules become connected with outgrowths from the mesonephros, which form the efferent ...
As the mesonephros degenerates, only the testis remains suspended. At its caudal end, the attachment is ligamentous and is ... Near the end of the second month, the testis and mesonephros are attached by the urogenital mesentery to the posterior ... which lie on the medial aspect of the mesonephros. The coelomic epithelium proliferates, and the underlying mesenchyme ...
MESONEPHROS. The number of segments occupied by the mesonephros is reduced, extending approximately from T-9 to L-3. The ... The mesonephric duct is narrow at its cranial end but enlarges as it courses caudally on the ventral aspect of the mesonephros ... It attaches to the medial side of the mesonephros by the gonadal mesentery where it comes into contact with some of the ...
A) Schematic drawing of the turtle gonad-mesonephros complex. (B) Timeline for ovarian cell proliferation analysis. (C,D) ... The brain and gonad-mesonephros complex were dissected in situ, incubated in Bouins solution (Sigma-Aldrich, Saint Louis, MO, ... To evaluate ovarian cell proliferation, at least two gonad-mesonephros complexes per nest were frozen, cryosectioned at 30 μm ... In this study, ovarian weight was not formally evaluated, since each was dissected together with the mesonephros. Interestingly ...
The transcriptional landscape of the Aorta-Gonad-Mesonephros hematopoietic microenvironment. C Durand (France) ...
Development of the mesonephros, metanephros and gonads in the foetal dog. Funct Dev Morphol 1991;1:59-63. ... Development of the mesonephros, metanephros and gonads in the foetal dog. Funct Dev Morphol 1991;1:59-63. ... Development of the mesonephros, metanephros and gonads in the foetal dog. . Funct Dev Morphol. 1991. ;. 1. :. 59. -. 63. .. ), ... Development of the mesonephros, metanephros and gonads in the foetal dog. . Funct Dev Morphol. 1991. ;. 1. :. 59. -. 63. .. ), ...
mesonephros (xenopus). XAO:0000141. reproductive system (xenopus). XAO:0000142. renal system (xenopus). XAO:0000143. ureter ( ...
pMKK4-positive cells were found to be positive for pHH3 too, both in the gonad and adjacent mesonephros (Figure 6B-6D). We then ... F) Culture of an XY byg/byg gonad with a marked mesonephros reveals negligible cell migration into the gonad (indicated by the ... The gonad (left) is separated from the mesonephros (right) by a dotted white line. (E-G) Transverse sections of 21 ts XY gonad ... E) Culture of a wild-type XY gonad adjacent to a stage-matched mesonephros derived from a line expressing GFP (recombination) ...
29] In males, the left testicle or other derivatives of the mesonephros connect to splenic tissue, usually an accessory spleen ...
Taylor, E., Taoudi, S., and Medvinsky, A. (2010). "Hematopoietic stem cell activity in the aorta-gonad-mesonephros region ...
Differentiation of human embryonic stem cells to HOXA+ hemogenic vasculature that resembles the aorta-gonad-mesonephros. ( ...
search results: mesonephros Search Atlas 5-1 Atlas 5-4 Atlas 5-5 Atlas 5-6 Atlas 6-4 Atlas 6-5 Atlas 6-7 Atlas 7-2 Atlas 7-4 ... A new longitudinal channel called the subcardinal vein begins to develop along the medial side of the mesonephros. It gradually ... in a longitudinal manner toward the heart in the lateral part of the dorsal body wall between the somites and mesonephros. It ... enlarges and eventually takes over the drainage of the expanding mesonephros. The subcardinal vein drains into the postcardinal ...
A pair of excretory ducts of the middle kidneys (MESONEPHROI) of an embryo, also called mesonephric ducts. In higher ...
... c-Myb-positive cells in the mesonephros and fetal liver give rise to a mix of long- and shorter-lived populations. Microglia ... the yolk sac and the aorta-gonad mesonephros. From there, macrophages take one of two routes: they migrate directly to their ... it was demonstrated that most macrophages originate prenatally either from the yolk sac or from the aorta-gonad mesonephros, ...
Mesonephros. Main article: Mesonephros. Each pronephric duct grows towards the tail of the embryo, and in doing so induces ... The mammalian mesonephros is similar to the kidneys of aquatic amphibians and fishes. ... mesonephros, and metanephros.[5] (The plural forms of these terms end in -oi.) ...
Mesonephros. Main article: Mesonephros. Each pronephric duct grows towards the tail of the embryo, and in doing so induces ... The mammalian mesonephros is similar to the kidneys of aquatic amphibians and fishes. ... mesonephros, and metanephros.[5] (The plural forms of these terms end in -oi.) ...
Mesonephros. The mesonephros develops caudally (inferiorly) to the pronephros. First, the presence of the pronephric duct ... Mesonephros. The mesonephros develops caudally (inferiorly) to the pronephros. First, the presence of the pronephric duct ... Fig 2 - The sequential development and degeneration of the pronephros and mesonephros, and the induction of the ureteric bud ... Fig 2 - The sequential development and degeneration of the pronephros and mesonephros, and the induction of the ureteric bud ...
Then I just needed to add somites along the back and the mesonephros and trigeminal ganglion. An actual embryo will have 43 ...
... prolonged persistence of nephrostomes in the mesonephros) [41]. The Desmostylia were also amphibious and probably used to live ...
mesonephros + mesopodial skeleton + metanephric capsule metanephric collecting duct + metanephric cortex mesenchyme + ...
I-I) E10.5 Nkx2-5irescre;ROSAYFP embryos sectioned at the level of the aorta gonad mesonephros (AGM) region and ...
... mesonephros, and metanephros. It explains why the origin and development of the urinary and reproductive systems are considered ...
... differentiation of mouse ESCs and favor the development of definitive HSCs from pre-HSCs in the mouse aorta-gonad-mesonephros ( ...
Disa studime sugjerojnë se acidi retinoik që rrjedh nga veshka primitive (mesonephros) stimulon mejozën në oogonia embrionale ...
... the fetus is equipped with both male and female genital ducts derived from the mesonephros. Mullerian ducts serve as the analog ...
  • moreover, they also promote the hematopoietic differentiation of mouse ESCs and favor the development of definitive HSCs from pre-HSCs in the mouse aorta-gonad-mesonephros (AGM) region [ 8 ]. (biomedcentral.com)
  • These more advanced hematopoietic progenitors isolated from the aorta-gonad-mesonephros (AGM) region at embryonic day 9.5 to 10 can give rise to lymphoid lineages and are LT reconstituting definitive HSCs, but since this time point is after the establishment of the circulatory system in the embryo their source was difficult to determine [ 13 ]. (biomedcentral.com)
  • Across vertebrate species, definitive HSCs are believed to be generated in the aorta-gonad-mesonephros (AGM) region. (amegroups.org)
  • The mesonephros persists and forms the anterior portion of the permanent kidneys in fish and amphibians, but in reptiles, birds, and mammals, it atrophies and for the most part disappears rapidly as the permanent kidney (metanephros) begins to develop during the sixth or seventh week. (wikipedia.org)
  • the pronephros, the mesonephros, and the metanephros. (teachmeanatomy.info)
  • This chapter begins with intermediate mesoderm, and discusses the origin of the kidneys in human development, including the pronephros, mesonephros, and metanephros. (taylorfrancis.com)
  • The metanephric mesenchyme (mm, dark grey) lies posterior and dorsal to the mesonephros and will develop into the metanephros (kidney). (atlas-d2k.org)
  • They arrive at the primitive gonads early in the fifth week of development and, during the sixth week, invade the genital ridges, which lie on the medial aspect of the mesonephros. (medscape.com)
  • The mesonephric duct is narrow at its cranial end but enlarges as it courses caudally on the ventral aspect of the mesonephros to terminate in the urogenital sinus. (ehd.org)
  • This arises as a distinct, rostro-caudally elongated mound of tissue that develops on the medial aspect of the mesonephros . (atlas-d2k.org)
  • citation needed] The tubules collectively constitute the mesonephros. (wikipedia.org)
  • By the beginning of the fifth month of human development, only the ducts and a few of the tubules of the mesonephros remain. (wikipedia.org)
  • It attaches to the medial side of the mesonephros by the gonadal mesentery where it comes into contact with some of the mesonephric tubules. (ehd.org)
  • The uriniferous tubules of the kidney arise independently of the ureter in a backward prolongation of the tissue which, further forward, gives origin to the tubules of the mesonephros. (co.ma)
  • Cranial and caudal mesonephric tubules (mt, dark grey) develop within the mesonephros. (atlas-d2k.org)
  • A section through the C-6 neural crest, cranial end of the mesonephros and hepatic antrum. (ehd.org)
  • hence the metanephric tissue ceases to lie to the caudal end of the mesonephros. (co.ma)
  • 4. The medial position of the subcardinal vein to the mesonephros. (ehd.org)
  • The gonad (go, blue) lies medial to the mesonephros (mes, light grey) and is subdivided into anterior (a), central (c) and posterior (p) regions. (atlas-d2k.org)
  • F-J ) Cross sections through different stages of embryonic development corresponding to the embryos shown in A-D. The mouse Isl1- en (green, GFP) and control pCAAG-RFP (red). (elifesciences.org)
  • Mesonephros is a vestige, transient renal organ that functions only during embryonic development. (ehu.eus)
  • In females the mesonephros degenerates entirely, though vestigial structures such as Gartner's ducts, the epoophoron, and paroophoron are common. (wikipedia.org)
  • As the mesonephros degenerates, only the testis remains suspended. (medscape.com)
  • mesonephros the intermediate stage of renal development remains at this stage. (edu.au)
  • The nephric duct lies ventral to the mesonephros and metanephric mesenchyme. (atlas-d2k.org)
  • Near the end of the second month, the testis and mesonephros are attached by the urogenital mesentery to the posterior abdominal wall. (medscape.com)
  • 2. In the fetus, a fold of tunica vaginalis testis (the serous membrane surrounding the front and sides of the testicle) supporting the mesonephros and the developing testis. (wordinfo.info)
  • By Northern analysis the principal transcript expressed in the mesonephros and the anlage of the external genitalia on gestation day 18 appeared to be identical to the mRNA expressed in adult prostate and epididymis. (laprp.com)
  • the latter are formed in mesoderm, known as the metanephric cell mass, which is continuous at its anterior end with the tissue from which the mesonephros is derived. (co.ma)
  • A-H ) Time lapse analysis of a live chick embryo expressing GFP under the control of Nkx2-5- en analyzed at different time points. (elifesciences.org)
  • Section of the fold in the mesonephros of a chick embryo of the fourth day. (iiab.me)
  • The mesonephros (Greek: middle kidney) is one of three excretory organs that develop in vertebrates. (wikipedia.org)
  • The Wolffian body is composed of: mesonephros + paramesonephrotic blastema) The mesonephros acts as a structure similar to the kidney that, in humans, functions between the sixth and tenth weeks of embryological life. (wikipedia.org)
  • In humans, the mesonephros consists of units which are similar in structure and function to nephrons of the adult kidney. (wikipedia.org)
  • In the female, when the permanent kidney is rmed, the mesonephros and its duct undergo atrophy to a greater extent than in the ale, and they are only represented in the adult by the vestigial structures present in e broad ligament of the uterus (see pp. 1315 and 1316). (co.ma)
  • The origin of mesonephros from intermediate mesoderm and the dependence of its differentiation on the nephric or Wolffian duct have been well established. (ehu.eus)
  • citation needed] The mesonephros as a whole produces urine from the 6th through the 10th week of development. (wikipedia.org)
  • The process whose specific outcome is the progression of a nephron in the mesonephros over time, from its formation to the mature structure. (zfin.org)
  • Our laboratory was the first to show that HSCs are born in the aorta-gonad-mesonephros region of the developing mammalian embryo. (ed.ac.uk)
  • We combine index sorting of single cells from the embryonic aorta-gonad-mesonephros region with endothelial cell co-culture and transplantation to characterize the phenotypic properties and engraftment potential of single hematopoietic precursors. (jove.com)
  • Immature multipotent hematopoietic progenitors lacking bone-marrow repopulating activity in the aorta-gonad-mesonephros region of murine day 10 fetuses. (kyoto-u.ac.jp)
  • Intriguingly HSC location changes during development with hematopoiesis shifting from the yolk sac and aorta-gonad-mesonephros region to the placenta fetal liver and bone marrow.1 In adult life HSC remain in dynamic contact with bone marrow niches and can also be found in extramedullary sites such as spleen liver and blood at various levels in response to stress or experimental stimuli. (bio-cavagnou.info)
  • The analysis focused on the hematopoietic cells from which immune cells are derived, as well as on the yolk sac (YS) and the aorta-gonad-mesonephros (AGM), which are involved in hematopoiesis during the fetal stage. (neurosciencenews.com)
  • It is found that both in aorta-gonad-mesonephros (AGM) and yolk sac (YS) progenitors, the dysregulation of HDAC1-mediated epigenetic machinery alters definitive hematopoiesis during embryogenesis and downregulates the expression of the AP-1 complex for microglia development. (neurosciencenews.com)
  • While the yolk sac is the first tissue in the mammalian conceptus to visibly exhibit hematopoietic cells, the intrabody region-which at different stages of development includes the splanchnopleural mesoderm, para-aortic splanchnopleura (PAS) and the aorta-gonad-mesonephros (AGM) region-clearly contains more potent undifferentiated hematopoietic progenitors and stem cells before the yolk sac. (ox.ac.uk)
  • The mesonephros is included in the Wolffian body after Caspar Friedrich Wolff who described it in 1759. (wikipedia.org)
  • The Wolffian body is composed of: mesonephros + paramesonephrotic blastema) The mesonephros acts as a structure similar to the kidney that, in humans, functions between the sixth and tenth weeks of embryological life. (wikipedia.org)
  • The second system consists of the mesonephroi (singular = mesonephros) and the mesonephric (Wolffian) ducts. (bmj.com)
  • Different cell-intrinsic and extrinsic factors direct the specification of early mesodermal progenitor cells towards hematopoietic stem cells (HSC), which arise in the aorta-gonad-mesonephros (AGM) region, mature in the fetal liver and finally home and reside in the bone marrow. (haematologica.org)
  • Mesonephroi are the permanent kidneys in adult amphibians and fish. (nih.gov)
  • This historic 1918 paper by Bremer describes the mesonephros, kidney and placenta in different animals. (edu.au)
  • The developing ovary and mesonephros were fluoresently stained with an endothelial and germ cell marker called PECAM (platelet endothelial cell adhesion molecule). (ucsd.edu)
  • The long projections extending from the right are the endothelial cells migrating into the developing ovary from the adjacent mesonephros. (ucsd.edu)
  • In females the mesonephros degenerates entirely, though vestigial structures such as Gartner's ducts, the epoophoron, and paroophoron are common. (wikipedia.org)
  • Sanjuan-Pla A, Romero-Moya D, Prieto C, Bueno C, Bigas A, Menendez P. Intra-bone marrow transplantation confers superior multilineage engraftment of murine aorta-gonad mesonephros cells over intravenous transplantation. (upf.edu)
  • Begin by adding Aorta-Gonad-Mesonephros, AGM, tissues dissected from embryos between 9.5 and 11.5 days post coitum to a 15 milliliter conical tube containing 10 milliliters of PBS supplemented with 10%FBS on ice. (jove.com)
  • If, then, the mesonephros had functioned as an excretory organ, there must necessarily have been an interruption of this function on its degeneration. (edu.au)
  • One theory for the development of SNT is that there is incomplete degeneration of a portion of the mesonephros and subsequent development of peritoneal bands [ 3 ]. (hindawi.com)
  • One of a pair of excretory organs (mesonephroi) which grows caudally to the first pair ( PRONEPHROI ) during development. (nih.gov)
  • Stromal cell lines from mouse aorta-gonads-mesonephros subregions are potent supporters of hematopoietic stem cell activity. (ox.ac.uk)
  • the latter are formed in mesoderm, known as the metanephric cell mass, which is continuous at its anterior end with the tissue from which the mesonephros is derived. (co.ma)