Arteries which arise from the abdominal aorta and distribute to most of the intestines.
A large vessel supplying the whole length of the small intestine except the superior part of the duodenum. It also supplies the cecum and the ascending part of the colon and about half the transverse part of the colon. It arises from the anterior surface of the aorta below the celiac artery at the level of the first lumbar vertebra.
The artery supplying nearly all the left half of the transverse colon, the whole of the descending colon, the sigmoid colon, and the greater part of the rectum. It is smaller than the superior mesenteric artery (MESENTERIC ARTERY, SUPERIOR) and arises from the aorta above its bifurcation into the common iliac arteries.
The vessels carrying blood away from the heart.
Obstruction of the flow in the SPLANCHNIC CIRCULATION by ATHEROSCLEROSIS; EMBOLISM; THROMBOSIS; STENOSIS; TRAUMA; and compression or intrinsic pressure from adjacent tumors. Rare causes are drugs, intestinal parasites, and vascular immunoinflammatory diseases such as PERIARTERITIS NODOSA and THROMBOANGIITIS OBLITERANS. (From Juergens et al., Peripheral Vascular Diseases, 5th ed, pp295-6)
DUODENAL OBSTRUCTION by the superior mesenteric artery (MESENTERIC ARTERY, SUPERIOR) which travels in the root of the MESENTERY and crosses over the DUODENUM. The syndrome is characterized by the dilated proximal duodenum and STOMACH, bloating, ABDOMINAL CRAMPS, and VOMITING. Often it is observed in patient with body casts after spinal surgery.
The arterial trunk that arises from the abdominal aorta and after a short course divides into the left gastric, common hepatic and splenic arteries.
The short wide vessel arising from the conus arteriosus of the right ventricle and conveying unaerated blood to the lungs.
A branch of the abdominal aorta which supplies the kidneys, adrenal glands and ureters.
The arterial blood vessels supplying the CEREBRUM.
The nonstriated involuntary muscle tissue of blood vessels.
The physiological widening of BLOOD VESSELS by relaxing the underlying VASCULAR SMOOTH MUSCLE.
Either of the two principal arteries on both sides of the neck that supply blood to the head and neck; each divides into two branches, the internal carotid artery and the external carotid artery.
The physiological narrowing of BLOOD VESSELS by contraction of the VASCULAR SMOOTH MUSCLE.
The main artery of the thigh, a continuation of the external iliac artery.
The circulation of blood through the BLOOD VESSELS supplying the abdominal VISCERA.
The artery formed by the union of the right and left vertebral arteries; it runs from the lower to the upper border of the pons, where it bifurcates into the two posterior cerebral arteries.
Endogenously-synthesized compounds that influence biological processes not otherwise classified under ENZYMES; HORMONES or HORMONE ANTAGONISTS.
Drugs used to cause constriction of the blood vessels.
Drugs used to cause dilation of the blood vessels.
Veins which return blood from the intestines; the inferior mesenteric vein empties into the splenic vein, the superior mesenteric vein joins the splenic vein to form the portal vein.
Either of two large arteries originating from the abdominal aorta; they supply blood to the pelvis, abdominal wall and legs.
The largest branch of the celiac trunk with distribution to the spleen, pancreas, stomach and greater omentum.
Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
The first branch of the SUBCLAVIAN ARTERY with distribution to muscles of the NECK; VERTEBRAE; SPINAL CORD; CEREBELLUM; and interior of the CEREBRUM.
Surgical therapy of ischemic coronary artery disease achieved by grafting a section of saphenous vein, internal mammary artery, or other substitute between the aorta and the obstructed coronary artery distal to the obstructive lesion.
A branch of the celiac artery that distributes to the stomach, pancreas, duodenum, liver, gallbladder, and greater omentum.
The recording of muscular movements. The apparatus is called a myograph, the record or tracing, a myogram. (From Stedman, 25th ed)
An alpha-1 adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent.
The direct continuation of the brachial trunk, originating at the bifurcation of the brachial artery opposite the neck of the radius. Its branches may be divided into three groups corresponding to the three regions in which the vessel is situated, the forearm, wrist, and hand.
Arteries originating from the subclavian or axillary arteries and distributing to the anterior thoracic wall, mediastinal structures, diaphragm, pectoral muscles and mammary gland.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.
Branch of the common carotid artery which supplies the anterior part of the brain, the eye and its appendages, the forehead and nose.
Artery arising from the brachiocephalic trunk on the right side and from the arch of the aorta on the left side. It distributes to the neck, thoracic wall, spinal cord, brain, meninges, and upper limb.
Surgical formation of an opening into the DUODENUM.
A strain of Rattus norvegicus used as a normotensive control for the spontaneous hypertensive rats (SHR).
That phase of a muscle twitch during which a muscle returns to a resting position.
Pathological conditions involving the CAROTID ARTERIES, including the common, internal, and external carotid arteries. ATHEROSCLEROSIS and TRAUMA are relatively frequent causes of carotid artery pathology.
A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
The veins and arteries of the HEART.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Radiography of blood vessels after injection of a contrast medium.
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
The continuation of the axillary artery; it branches into the radial and ulnar arteries.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Paracrine substances produced by the VASCULAR ENDOTHELIUM with VASCULAR SMOOTH MUSCLE relaxation (VASODILATION) activities. Several factors have been identified, including NITRIC OXIDE and PROSTACYCLIN.
The two principal arteries supplying the structures of the head and neck. They ascend in the neck, one on each side, and at the level of the upper border of the thyroid cartilage, each divides into two branches, the external (CAROTID ARTERY, EXTERNAL) and internal (CAROTID ARTERY, INTERNAL) carotid arteries.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
A strain of Rattus norvegicus with elevated blood pressure used as a model for studying hypertension and stroke.
Pathological outpouching or sac-like dilatation in the wall of any blood vessel (ARTERIES or VEINS) or the heart (HEART ANEURYSM). It indicates a thin and weakened area in the wall which may later rupture. Aneurysms are classified by location, etiology, or other characteristics.
Narrowing or occlusion of the RENAL ARTERY or arteries. It is due usually to ATHEROSCLEROSIS; FIBROMUSCULAR DYSPLASIA; THROMBOSIS; EMBOLISM, or external pressure. The reduced renal perfusion can lead to renovascular hypertension (HYPERTENSION, RENOVASCULAR).
Artery originating from the internal carotid artery and distributing to the eye, orbit and adjacent facial structures.
A stable prostaglandin endoperoxide analog which serves as a thromboxane mimetic. Its actions include mimicking the hydro-osmotic effect of VASOPRESSIN and activation of TYPE C PHOSPHOLIPASES. (From J Pharmacol Exp Ther 1983;224(1): 108-117; Biochem J 1984;222(1):103-110)
A 37-amino acid residue peptide isolated from the scorpion Leiurus quinquestriatus hebraeus. It is a neurotoxin that inhibits calcium activated potassium channels.
A white crystal or crystalline powder used in BUFFERS; FERTILIZERS; and EXPLOSIVES. It can be used to replenish ELECTROLYTES and restore WATER-ELECTROLYTE BALANCE in treating HYPOKALEMIA.
A non-selective inhibitor of nitric oxide synthase. It has been used experimentally to induce hypertension.
The flow of BLOOD through or around an organ or region of the body.
Pathological processes which result in the partial or complete obstruction of ARTERIES. They are characterized by greatly reduced or absence of blood flow through these vessels. They are also known as arterial insufficiency.
Specialized arterial vessels in the umbilical cord. They carry waste and deoxygenated blood from the FETUS to the mother via the PLACENTA. In humans, there are usually two umbilical arteries but sometimes one.
The largest of the cerebral arteries. It trifurcates into temporal, frontal, and parietal branches supplying blood to most of the parenchyma of these lobes in the CEREBRAL CORTEX. These are the areas involved in motor, sensory, and speech activities.
Arteries originating from the subclavian or axillary arteries and distributing to the anterior thoracic wall, mediastinal structures, diaphragm, pectoral muscles, mammary gland and the axillary aspect of the chest wall.
Elements of limited time intervals, contributing to particular results or situations.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
Devices that provide support for tubular structures that are being anastomosed or for body cavities during skin grafting.
The condition of an anatomical structure's being constricted beyond normal dimensions.
Arteries arising from the external carotid or the maxillary artery and distributing to the temporal region.
Left bronchial arteries arise from the thoracic aorta, the right from the first aortic intercostal or the upper left bronchial artery; they supply the bronchi and the lower trachea.
A non-steroidal anti-inflammatory agent (NSAID) that inhibits the enzyme cyclooxygenase necessary for the formation of prostaglandins and other autacoids. It also inhibits the motility of polymorphonuclear leukocytes.
Ultrasonography applying the Doppler effect, with frequency-shifted ultrasound reflections produced by moving targets (usually red blood cells) in the bloodstream along the ultrasound axis in direct proportion to the velocity of movement of the targets, to determine both direction and velocity of blood flow. (Stedman, 25th ed)
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
A powerful vasodilator used in emergencies to lower blood pressure or to improve cardiac function. It is also an indicator for free sulfhydryl groups in proteins.
The continuation of the femoral artery coursing through the popliteal fossa; it divides into the anterior and posterior tibial arteries.
The main trunk of the systemic arteries.
The larger of the two terminal branches of the brachial artery, beginning about one centimeter distal to the bend of the elbow. Like the RADIAL ARTERY, its branches may be divided into three groups corresponding to their locations in the forearm, wrist, and hand.
An NADPH-dependent enzyme that catalyzes the conversion of L-ARGININE and OXYGEN to produce CITRULLINE and NITRIC OXIDE.
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
The portion of the descending aorta proceeding from the arch of the aorta and extending to the DIAPHRAGM, eventually connecting to the ABDOMINAL AORTA.
The neural systems which act on VASCULAR SMOOTH MUSCLE to control blood vessel diameter. The major neural control is through the sympathetic nervous system.
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
A highly neurotoxic polypeptide from the venom of the honey bee (Apis mellifera). It consists of 18 amino acids with two disulfide bridges and causes hyperexcitability resulting in convulsions and respiratory paralysis.
A branch arising from the internal iliac artery in females, that supplies blood to the uterus.
An inhibitor of nitric oxide synthetase which has been shown to prevent glutamate toxicity. Nitroarginine has been experimentally tested for its ability to prevent ammonia toxicity and ammonia-induced alterations in brain energy and ammonia metabolites. (Neurochem Res 1995:200(4):451-6)
The force that opposes the flow of BLOOD through a vascular bed. It is equal to the difference in BLOOD PRESSURE across the vascular bed divided by the CARDIAC OUTPUT.
A steroid metabolite that is the 11-deoxy derivative of CORTICOSTERONE and the 21-hydroxy derivative of PROGESTERONE.
The voltage differences across a membrane. For cellular membranes they are computed by subtracting the voltage measured outside the membrane from the voltage measured inside the membrane. They result from differences of inside versus outside concentration of potassium, sodium, chloride, and other ions across cells' or ORGANELLES membranes. For excitable cells, the resting membrane potentials range between -30 and -100 millivolts. Physical, chemical, or electrical stimuli can make a membrane potential more negative (hyperpolarization), or less negative (depolarization).
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
Radiography of the vascular system of the heart muscle after injection of a contrast medium.
The aorta from the DIAPHRAGM to the bifurcation into the right and left common iliac arteries.
A CALCIUM-dependent, constitutively-expressed form of nitric oxide synthase found primarily in ENDOTHELIAL CELLS.
The state of activity or tension of a muscle beyond that related to its physical properties, that is, its active resistance to stretch. In skeletal muscle, tonus is dependent upon efferent innervation. (Stedman, 25th ed)
Branch of the common carotid artery which supplies the exterior of the head, the face, and the greater part of the neck.
Surgical insertion of BLOOD VESSEL PROSTHESES to repair injured or diseased blood vessels.
A class of drugs that act by inhibition of potassium efflux through cell membranes. Blockade of potassium channels prolongs the duration of ACTION POTENTIALS. They are used as ANTI-ARRHYTHMIA AGENTS and VASODILATOR AGENTS.
A potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.
Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. Adrenergic alpha-antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
Damages to the CAROTID ARTERIES caused either by blunt force or penetrating trauma, such as CRANIOCEREBRAL TRAUMA; THORACIC INJURIES; and NECK INJURIES. Damaged carotid arteries can lead to CAROTID ARTERY THROMBOSIS; CAROTID-CAVERNOUS SINUS FISTULA; pseudoaneurysm formation; and INTERNAL CAROTID ARTERY DISSECTION. (From Am J Forensic Med Pathol 1997, 18:251; J Trauma 1994, 37:473)
Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the tissue (REPERFUSION), including swelling; HEMORRHAGE; NECROSIS; and damage from FREE RADICALS. The most common instance is MYOCARDIAL REPERFUSION INJURY.
An unstable intermediate between the prostaglandin endoperoxides and thromboxane B2. The compound has a bicyclic oxaneoxetane structure. It is a potent inducer of platelet aggregation and causes vasoconstriction. It is the principal component of rabbit aorta contracting substance (RCS).
A 21-amino acid peptide produced in a variety of tissues including endothelial and vascular smooth-muscle cells, neurons and astrocytes in the central nervous system, and endometrial cells. It acts as a modulator of vasomotor tone, cell proliferation, and hormone production. (N Eng J Med 1995;333(6):356-63)
Operative procedures for the treatment of vascular disorders.
Use of electric potential or currents to elicit biological responses.
A potassium-channel opening vasodilator that has been investigated in the management of hypertension. It has also been tried in patients with asthma. (Martindale, The Extra Pharmacopoeia, 30th ed, p352)
A method of hemostasis utilizing various agents such as Gelfoam, silastic, metal, glass, or plastic pellets, autologous clot, fat, and muscle as emboli. It has been used in the treatment of spinal cord and INTRACRANIAL ARTERIOVENOUS MALFORMATIONS, renal arteriovenous fistulas, gastrointestinal bleeding, epistaxis, hypersplenism, certain highly vascular tumors, traumatic rupture of blood vessels, and control of operative hemorrhage.
Application of a ligature to tie a vessel or strangulate a part.
The degree to which BLOOD VESSELS are not blocked or obstructed.
Muscular contractions characterized by increase in tension without change in length.
The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.
A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.
The thoracolumbar division of the autonomic nervous system. Sympathetic preganglionic fibers originate in neurons of the intermediolateral column of the spinal cord and project to the paravertebral and prevertebral ganglia, which in turn project to target organs. The sympathetic nervous system mediates the body's response to stressful situations, i.e., the fight or flight reactions. It often acts reciprocally to the parasympathetic system.
Not an aneurysm but a well-defined collection of blood and CONNECTIVE TISSUE outside the wall of a blood vessel or the heart. It is the containment of a ruptured blood vessel or heart, such as sealing a rupture of the left ventricle. False aneurysm is formed by organized THROMBUS and HEMATOMA in surrounding tissue.
Calcitonin gene-related peptide. A 37-amino acid peptide derived from the calcitonin gene. It occurs as a result of alternative processing of mRNA from the calcitonin gene. The neuropeptide is widely distributed in neural tissue of the brain, gut, perivascular nerves, and other tissue. The peptide produces multiple biological effects and has both circulatory and neurotransmitter modes of action. In particular, it is a potent endogenous vasodilator.
Use of a balloon catheter for dilation of an occluded artery. It is used in treatment of arterial occlusive diseases, including renal artery stenosis and arterial occlusions in the leg. For the specific technique of BALLOON DILATION in coronary arteries, ANGIOPLASTY, BALLOON, CORONARY is available.
An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
An alpha-1 adrenergic agonist that causes prolonged peripheral VASOCONSTRICTION.
Any of the large interior organs in any one of the three great cavities of the body, especially in the abdomen.
An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.
Non-striated, elongated, spindle-shaped cells found lining the digestive tract, uterus, and blood vessels. They are derived from specialized myoblasts (MYOBLASTS, SMOOTH MUSCLE).
Aneurysm caused by a tear in the TUNICA INTIMA of a blood vessel leading to interstitial HEMORRHAGE, and splitting (dissecting) of the vessel wall, often involving the AORTA. Dissection between the intima and media causes luminal occlusion. Dissection at the media, or between the media and the outer adventitia causes aneurismal dilation.
Drugs that selectively bind to and activate alpha adrenergic receptors.
A subclass of alpha-adrenergic receptors that mediate contraction of SMOOTH MUSCLE in a variety of tissues such as ARTERIOLES; VEINS; and the UTERUS. They are usually found on postsynaptic membranes and signal through GQ-G11 G-PROTEINS.
A short thick vein formed by union of the superior mesenteric vein and the splenic vein.
Non-invasive method of vascular imaging and determination of internal anatomy without injection of contrast media or radiation exposure. The technique is used especially in CEREBRAL ANGIOGRAPHY as well as for studies of other vascular structures.
NECROSIS occurring in the MIDDLE CEREBRAL ARTERY distribution system which brings blood to the entire lateral aspects of each CEREBRAL HEMISPHERE. Clinical signs include impaired cognition; APHASIA; AGRAPHIA; weak and numbness in the face and arms, contralaterally or bilaterally depending on the infarction.
The continuation of the subclavian artery; it distributes over the upper limb, axilla, chest and shoulder.
A layer of the peritoneum which attaches the abdominal viscera to the ABDOMINAL WALL and conveys their blood vessels and nerves.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Pentacyclic triterpene saponins, biosynthesized from protoaescigenin and barringtogenol, occurring in the seeds of AESCULUS. It inhibits edema formation and decreases vascular fragility.
Sudden ISCHEMIA in the RETINA due to blocked blood flow through the CENTRAL RETINAL ARTERY or its branches leading to sudden complete or partial loss of vision, respectively, in the eye.
Short thick veins which return blood from the kidneys to the vena cava.
The tearing or bursting of the weakened wall of the aneurysmal sac, usually heralded by sudden worsening pain. The great danger of a ruptured aneurysm is the large amount of blood spilling into the surrounding tissues and cavities, causing HEMORRHAGIC SHOCK.
Hindrance of the passage of luminal contents in the DUODENUM. Duodenal obstruction can be partial or complete, and caused by intrinsic or extrinsic factors. Simple obstruction is associated with diminished or stopped flow of luminal contents. Strangulating obstruction is associated with impaired blood flow to the duodenum in addition to obstructed flow of luminal contents.
Potassium channels whose activation is dependent on intracellular calcium concentrations.
Blood clot formation in any part of the CAROTID ARTERIES. This may produce CAROTID STENOSIS or occlusion of the vessel, leading to TRANSIENT ISCHEMIC ATTACK; CEREBRAL INFARCTION; or AMAUROSIS FUGAX.
A class of drugs that act by selective inhibition of calcium influx through cellular membranes.
Compounds that bind to and activate ADRENERGIC ALPHA-1 RECEPTORS.
An abnormal balloon- or sac-like dilatation in the wall of the ABDOMINAL AORTA which gives rise to the visceral, the parietal, and the terminal (iliac) branches below the aortic hiatus at the diaphragm.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
An octapeptide that is a potent but labile vasoconstrictor. It is produced from angiotensin I after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME. The amino acid in position 5 varies in different species. To block VASOCONSTRICTION and HYPERTENSION effect of angiotensin II, patients are often treated with ACE INHIBITORS or with ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Arteries which supply the dura mater.
The section of the alimentary canal from the STOMACH to the ANAL CANAL. It includes the LARGE INTESTINE and SMALL INTESTINE.
Cell membrane glycoproteins that are selectively permeable to potassium ions. At least eight major groups of K channels exist and they are made up of dozens of different subunits.
Ultrasonography applying the Doppler effect combined with real-time imaging. The real-time image is created by rapid movement of the ultrasound beam. A powerful advantage of this technique is the ability to estimate the velocity of flow from the Doppler shift frequency.
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
An antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.
Surgical union or shunt between ducts, tubes or vessels. It may be end-to-end, end-to-side, side-to-end, or side-to-side.
Pathological processes involving any of the BLOOD VESSELS in the cardiac or peripheral circulation. They include diseases of ARTERIES; VEINS; and rest of the vasculature system in the body.
A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.
Flunarizine is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity. It is effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy.
Radiographic visualization of the aorta and its branches by injection of contrast media, using percutaneous puncture or catheterization procedures.
Narrowing or stricture of any part of the CAROTID ARTERIES, most often due to atherosclerotic plaque formation. Ulcerations may form in atherosclerotic plaques and induce THROMBUS formation. Platelet or cholesterol emboli may arise from stenotic carotid lesions and induce a TRANSIENT ISCHEMIC ATTACK; CEREBROVASCULAR ACCIDENT; or temporary blindness (AMAUROSIS FUGAX). (From Adams et al., Principles of Neurology, 6th ed, pp 822-3)
21-Amino-acid peptides produced by vascular endothelial cells and functioning as potent vasoconstrictors. The endothelin family consists of three members, ENDOTHELIN-1; ENDOTHELIN-2; and ENDOTHELIN-3. All three peptides contain 21 amino acids, but vary in amino acid composition. The three peptides produce vasoconstrictor and pressor responses in various parts of the body. However, the quantitative profiles of the pharmacological activities are considerably different among the three isopeptides.
Compounds with a core of fused benzo-pyran rings.
A nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of RAYNAUD DISEASE and frostbite, clonidine withdrawal syndrome, impotence, and peripheral vascular disease.
A compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Solutions in water or alcohol have a deep blue color. Methylene blue is used as a bacteriologic stain and as an indicator. It inhibits GUANYLATE CYCLASE, and has been used to treat cyanide poisoning and to lower levels of METHEMOGLOBIN.
The synapse between a neuron (presynaptic) and an effector cell other than another neuron (postsynaptic). Neuroeffector junctions include synapses onto muscles and onto secretory cells.
A derivative of the NIACINAMIDE that is structurally combined with an organic nitrate. It is a potassium-channel opener that causes vasodilatation of arterioles and large coronary arteries. Its nitrate-like properties produce venous vasodilation through stimulation of guanylate cyclase.
A guanidine that opens POTASSIUM CHANNELS producing direct peripheral vasodilatation of the ARTERIOLES. It reduces BLOOD PRESSURE and peripheral resistance and produces fluid retention. (Martindale The Extra Pharmacopoeia, 31st ed)
Minimally invasive procedures, diagnostic or therapeutic, performed within the BLOOD VESSELS. They may be perfomed via ANGIOSCOPY; INTERVENTIONAL MAGNETIC RESONANCE IMAGING; INTERVENTIONAL RADIOGRAPHY; or INTERVENTIONAL ULTRASONOGRAPHY.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
An essential amino acid that is physiologically active in the L-form.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Device constructed of either synthetic or biological material that is used for the repair of injured or diseased blood vessels.
A method of delineating blood vessels by subtracting a tissue background image from an image of tissue plus intravascular contrast material that attenuates the X-ray photons. The background image is determined from a digitized image taken a few moments before injection of the contrast material. The resulting angiogram is a high-contrast image of the vessel. This subtraction technique allows extraction of a high-intensity signal from the superimposed background information. The image is thus the result of the differential absorption of X-rays by different tissues.
Reconstruction or repair of a blood vessel, which includes the widening of a pathological narrowing of an artery or vein by the removal of atheromatous plaque material and/or the endothelial lining as well, or by dilatation (BALLOON ANGIOPLASTY) to compress an ATHEROMA. Except for ENDARTERECTOMY, usually these procedures are performed via catheterization as minimally invasive ENDOVASCULAR PROCEDURES.
A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.
Radiography of the vascular system of the brain after injection of a contrast medium.
A diverse group of agents, with unique chemical structures and biochemical requirements, which generate NITRIC OXIDE. These compounds have been used in the treatment of cardiovascular diseases and the management of acute myocardial infarction, acute and chronic congestive heart failure, and surgical control of blood pressure. (Adv Pharmacol 1995;34:361-81)
A competitive inhibitor of nitric oxide synthetase.
Use or insertion of a tubular device into a duct, blood vessel, hollow organ, or body cavity for injecting or withdrawing fluids for diagnostic or therapeutic purposes. It differs from INTUBATION in that the tube here is used to restore or maintain patency in obstructions.
A major class of calcium-activated potassium channels that were originally discovered in ERYTHROCYTES. They are found primarily in non-excitable CELLS and set up electrical gradients for PASSIVE ION TRANSPORT.
Drugs that bind to and block the activation of ADRENERGIC ALPHA-1 RECEPTORS.
Rhythmic, intermittent propagation of a fluid through a BLOOD VESSEL or piping system, in contrast to constant, smooth propagation, which produces laminar flow.
A volatile vasodilator which relieves ANGINA PECTORIS by stimulating GUANYLATE CYCLASE and lowering cytosolic calcium. It is also sometimes used for TOCOLYSIS and explosives.
Surgical formation of an opening through the ABDOMINAL WALL into the JEJUNUM, usually for enteral hyperalimentation.
Any of the tubular vessels conveying the blood (arteries, arterioles, capillaries, venules, and veins).
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Cell surface proteins that bind ENDOTHELINS with high affinity and trigger intracellular changes which influence the behavior of cells.
Delivery of drugs into an artery.
A branch of the external carotid artery which distributes to the deep structures of the face (internal maxillary) and to the side of the face and nose (external maxillary).
The portion of the GASTROINTESTINAL TRACT between the PYLORUS of the STOMACH and the ILEOCECAL VALVE of the LARGE INTESTINE. It is divisible into three portions: the DUODENUM, the JEJUNUM, and the ILEUM.
Cell surface proteins that bind PURINES with high affinity and trigger intracellular changes which influence the behavior of cells. The best characterized classes of purinergic receptors in mammals are the P1 receptors, which prefer ADENOSINE, and the P2 receptors, which prefer ATP or ADP.
Benzopyrroles with the nitrogen at the number one carbon adjacent to the benzyl portion, in contrast to ISOINDOLES which have the nitrogen away from the six-membered ring.
Guanosine cyclic 3',5'-(hydrogen phosphate). A guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'- and 5'-positions. It is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases. (From Merck Index, 11th ed)
The act of constricting.
The circulation of blood through the CORONARY VESSELS of the HEART.
The splitting of the vessel wall in one or both (left and right) internal carotid arteries (CAROTID ARTERY, INTERNAL). Interstitial hemorrhage into the media of the vessel wall can lead to occlusion of the internal carotid artery and aneurysm formation.
A group of compounds derived from unsaturated 20-carbon fatty acids, primarily arachidonic acid, via the cyclooxygenase pathway. They are extremely potent mediators of a diverse group of physiological processes.
Ultrasonography applying the Doppler effect, with the superposition of flow information as colors on a gray scale in a real-time image. This type of ultrasonography is well-suited to identifying the location of high-velocity flow (such as in a stenosis) or of mapping the extent of flow in a certain region.
Cell surface proteins that bind THROMBOXANES with high affinity and trigger intracellular changes influencing the behavior of cells. Some thromboxane receptors act via the inositol phosphate and diacylglycerol second messenger systems.
Blocking of a blood vessel by an embolus which can be a blood clot or other undissolved material in the blood stream.
An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues.
Coronary artery bypass surgery on a beating HEART without a CARDIOPULMONARY BYPASS (diverting the flow of blood from the heart and lungs through an oxygenator).
A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Caffeine's most notable pharmacological effect is as a central nervous system stimulant, increasing alertness and producing agitation. It also relaxes SMOOTH MUSCLE, stimulates CARDIAC MUSCLE, stimulates DIURESIS, and appears to be useful in the treatment of some types of headache. Several cellular actions of caffeine have been observed, but it is not entirely clear how each contributes to its pharmacological profile. Among the most important are inhibition of cyclic nucleotide PHOSPHODIESTERASES, antagonism of ADENOSINE RECEPTORS, and modulation of intracellular calcium handling.
Direct myocardial revascularization in which the internal mammary artery is anastomosed to the right coronary artery, circumflex artery, or anterior descending coronary artery. The internal mammary artery is the most frequent choice, especially for a single graft, for coronary artery bypass surgery.

Observations on some additional abnormalities in situs inversus viscerum. (1/2143)

The abnormal findings in a case of Situs inversus totalis are described. The duodenum was placed abnormally and retained its primitive mesentery. The proximal 22 in of jejunum were retroperitoneal. The attachment of the root of the mesentery to the posterior abdominal wall had a 7-shaped appearance, and there was a partial failure of the primitive mesocolon to adhere to the posterior abdominal wall. The common hepatic artery arose from the superior meseneric artery, which also provided a branch to the proximal jejunal loop. The right vagus nerve was found anterior to the oesophagus at the oesophageal hiatus in the diaphragm, and the left vagus was posterior. A double ureter was present on the right side. The findings are discussed in relation to mid-gut development.  (+info)

Acetylcholine-induced relaxation in blood vessels from endothelial nitric oxide synthase knockout mice. (2/2143)

1. Isometric tension was recorded in isolated rings of aorta, carotid, coronary and mesenteric arteries taken from endothelial nitric oxide synthase knockout mice (eNOS(-/-) mice) and the corresponding wild-type strain (eNOS(+/+) mice). The membrane potential of smooth muscle cells was measured in coronary arteries with intracellular microelectrodes. 2. In the isolated aorta, carotid and coronary arteries from the eNOS(+/+) mice, acetylcholine induced an endothelium-dependent relaxation which was inhibited by N(omega)-L-nitro-arginine. In contrast, in the mesenteric arteries, the inhibition of the cholinergic relaxation required the combination of N(omega)-L-nitro-arginine and indomethacin. 3. The isolated aorta, carotid and coronary arteries from the eNOS(-/-) mice did not relax in response to acetylcholine. However, acetylcholine produced an indomethacin-sensitive relaxation in the mesenteric artery from eNOS(-/-) mice. 4. The resting membrane potential of smooth muscle cells from isolated coronary arteries was significantly less negative in the eNOS(-/-) mice (-64.8 +/- 1.8 mV, n = 20 and -58.4 +/- 1.9 mV, n = 17, for eNOS(+/+) and eNOS(-/-) mice, respectively). In both strains, acetylcholine, bradykinin and substance P did not induce endothelium-dependent hyperpolarizations whereas cromakalim consistently produced hyperpolarizations (- 7.9 +/- 1.1 mV, n = 8 and -13.8 +/- 2.6 mV, n = 4, for eNOS(+/+) and eNOS(-/-) mice, respectively). 5. These findings demonstrate that in the blood vessels studied: (1) in the eNOS(+/+) mice, the endothelium-dependent relaxations to acetylcholine involve either NO or the combination of NO plus a product of cyclo-oxygenase but not EDHF; (2) in the eNOS(-/-) mice, NO-dependent responses and EDHF-like responses were not observed. In the mesenteric arteries acetylcholine releases a cyclo-oxygenase derivative.  (+info)

Studies of the role of endothelium-dependent nitric oxide release in the sustained vasodilator effects of corticotrophin releasing factor and sauvagine. (3/2143)

1. The mechanisms of the sustained vasodilator actions of corticotrophin-releasing factor (CRF) and sauvagine (SVG) were studied using rings of endothelium de-nuded rat thoracic aorta (RTA) and the isolated perfused rat superior mesenteric arterial vasculature (SMA). 2. SVG was approximately 50 fold more potent than CRF on RTA (EC40: 0.9 +/- 0.2 and 44 +/- 9 nM respectively, P < 0.05), and approximately 10 fold more active in the perfused SMA (ED40: 0.05 +/- 0.02 and 0.6 +/- 0.1 nmol respectively, P < 0.05). Single bolus injections of CRF (100 pmol) or SVG (15 pmol) in the perfused SMA caused reductions in perfusion pressure of 23 +/- 1 and 24 +/- 2% that lasted more than 20 min. 3. Removal of the endothelium in the perfused SMA with deoxycholic acid attenuated the vasodilatation and revealed two phases to the response; a short lasting direct action, and a sustained phase which was fully inhibited. 4. Inhibition of nitric oxide synthase with L-NAME (100 microM) L-NMMA (100 microM) or 2-ethyl-2-thiopseudourea (ETPU, 100 microM) had similar effects on the vasodilator responses to CRF as removal of the endothelium, suggesting a pivotal role for nitric oxide. However the selective guanylate cyclase inhibitor 1H-[l,2,4]oxadiazolo[4,3-alpha]quinoxalin-1-one (ODQ, 10 microM) did not affect the response to CRF. 5. High potassium (60 mM) completely inhibited the vasodilator response to CRF in the perfused SMA, indicating a role for K channels in this response. 6. Compared to other vasodilator agents acting via the release of NO, the actions of CRF and SVG are strikingly long-lasting, suggesting a novel mechanism of prolonged activation of nitric oxide synthase.  (+info)

Altered vascular reactivity following partial nephrectomy in the rat: a possible mechanism of the blood-pressure-lowering effect of heparin. (4/2143)

BACKGROUND: This study was designed to assess whether the antihypertensive effect of heparin in rats after renal mass reduction (RMR) is related to changes in nitric oxide activity, and to study in vitro the altered behaviour of resistance-sized arteries induced by chronic administration of heparin. METHODS: Male Wistar rats were assigned to one of two experimental protocols. In the first protocol, RMR rats received heparin (250 units/day s.c.) and tail systolic blood pressure (SBP) was measured weekly for 4 weeks. In a subgroup, urinary nitrate excretion (UNO3) and in vitro vascular reactivity of isolated perfused mesenteric arterial beds were measured 2 weeks after RMR. The second protocol assessed whether inhibition of NO synthesis with L-NAME (70 mg/l added to the drinking water) prevents the blood-pressure-lowering effect of heparin. RESULTS: In untreated RMR rats SBP increased from 111+/-3 mmHg to 127+/-5 mmHg at 2 weeks and 139+/-5 mmHg at 4 weeks. In contrast, in RMR rats treated with heparin, SBP was 114 +/-3 mmHg at 2 weeks and 115+/-4 mmHg at 4 weeks (P<0.05 for both). Treatment with L-NAME increased SBP both in untreated and heparin-treated RMR groups. Two weeks after nephrectomy daily urinary nitrate increased significantly more in RMR rats treated with heparin than in untreated RMR rats (22+/-2 vs 14.2+/-2.3 micromol/day, P<0.05). In vitro studies performed at 2 weeks showed that vessels of untreated RMR rats had a blunted vasodilator response to acetylcholine that was restored to levels similar to that of controls in the heparin-treated group. CONCLUSIONS: These results suggest that, in rats after renal ablation, heparin may exert its antihypertensive effect, at least in part, by affecting the altered behaviour of resistance vessels during the development phase of hypertension. Increased NO production may contribute to this effect.  (+info)

Maintenance of normal agonist-induced endothelium-dependent relaxation in uraemic and hypertensive resistance vessels. (5/2143)

BACKGROUND: The nitric oxide system has been implicated in several diseases with vascular complications including diabetes mellitus and hypertension. Despite the high prevalence of hypertension and cardiovascular complications in renal failure few studies have examined vascular and endothelial function in uraemia. We therefore chose to study possible abnormalities of the nitric oxide vasodilator system in an animal model of chronic renal failure. METHODS: Adult spontaneous hypertensive rats and Wistar Kyoto rats were subjected to a 5/6 nephrectomy with control animals having sham operations. After 4 weeks blood pressure was recorded and the animals were sacrificed. Branches of the mesenteric arteries were isolated and mounted on a Mulvany myograph. All experiments were performed in the presence of indomethacin (10(-5) M). The vessels were first preconstricted with noradrenaline, exposed to increasing concentrations of acetylcholine (10(-8) to 10(-4) M) and subsequently to sodium nitroprusside (10(-5) M). RESULTS: There was no difference in the relaxation of the four groups of vessels to any of the concentrations of acetylcholine used nor was there any significant difference in the EC50s (control Wistar Kyoto 6.1+/-1.4 x 10(-8) M; uraemic Wistar Kyoto 5.4+/-0.8 x 10(-8) M; control spontaneous hypertensive rats 4.5+/-0.6 x 10(-8) M; uraemic spontaneous hypertensive rats 6+/-0.7 x 10(-8) M). Vasodilatation in response to sodium nitroprusside was unchanged in uraemic vessels. In addition the vascular responses to both acetylcholine and sodium nitroprusside were unaltered in spontaneous hypertensive rats. CONCLUSIONS: We conclude that normal agonist-induced endothelium-dependent relaxation is maintained in experimental uraemia and hypertension.  (+info)

Modulation of temperature-induced tone by vasoconstrictor agents. (6/2143)

One of the primary cardiovascular adjustments to hyperthermia is a sympathetically mediated increase in vascular resistance in the viscera. Nonneural factors such as a change in vascular tone or reactivity may also contribute to this response. Therefore, the aim of this study was to determine whether vascular smooth muscle tone is altered during heating to physiologically relevant temperatures >37 degrees C. Gradually increasing bath temperature from 37 degrees C (normothermia) to 43 degrees C (severe hyperthermia) produced graded contractions in vascular ring segments from rat mesenteric arteries and thoracic aortae. In untreated rings these contractions were relatively small, whereas hyperthermia elicited near-maximal increases in tension when rings were constricted with phenylephrine or KCl before heating. In phenylephrine-treated mesenteric arterial rings, the contractile responses to heating were markedly attenuated by the Ca2+ channel antagonists nifedipine and diltiazem. Diltiazem also blocked the contractile responses to heating in thoracic aortic rings. These results demonstrate that hyperthermia has a limited effect on tension generation in rat vascular smooth muscle in the absence of vascular tone. However, in the presence of agonist-induced tone, tension generation during heating is markedly enhanced and dependent on extracellular Ca2+. In conclusion, these data suggest that local regulation of vascular tone can contribute to the hemodynamic adjustments to hyperthermia.  (+info)

Kir2.1 encodes the inward rectifier potassium channel in rat arterial smooth muscle cells. (7/2143)

1. The molecular nature of the strong inward rectifier K+ channel in vascular smooth muscle was explored by using isolated cell RT-PCR, cDNA cloning and expression techniques. 2. RT-PCR of RNA from single smooth muscle cells of rat cerebral (basilar), coronary and mesenteric arteries revealed transcripts for Kir2.1. Transcripts for Kir2.2 and Kir2.3 were not found. 3. Quantitative PCR analysis revealed significant differences in transcript levels of Kir2.1 between the different vascular preparations (n = 3; P < 0.05). A two-fold difference was detected between Kir2.1 mRNA and beta-actin mRNA in coronary arteries when compared with relative levels measured in mesenteric and basilar preparations. 4. Kir2.1 was cloned from rat mesenteric vascular smooth muscle cells and expressed in Xenopus oocytes. Currents were strongly inwardly rectifying and selective for K+. 5. The effect of extracellular Ba2+, Ca2+, Mg2+ and Cs2+ ions on cloned Kir2.1 channels expressed in Xenopus oocytes was examined. Ba2+ and Cs+ block were steeply voltage dependent, whereas block by external Ca2+ and Mg2+ exhibited little voltage dependence. The apparent half-block constants and voltage dependences for Ba2+, Cs+, Ca2+ and Mg2+ were very similar for inward rectifier K+ currents from native cells and cloned Kir2.1 channels expressed in oocytes. 6. Molecular studies demonstrate that Kir2.1 is the only member of the Kir2 channel subfamily present in vascular arterial smooth muscle cells. Expression of cloned Kir2.1 in Xenopus oocytes resulted in inward rectifier K+ currents that strongly resemble those that are observed in native vascular arterial smooth muscle cells. We conclude that Kir2.1 encodes for inward rectifier K+ channels in arterial smooth muscle.  (+info)

Mechanisms of hypoxic vasodilatation of isolated rat mesenteric arteries: a comparison with metabolic inhibition. (8/2143)

1. Hypoxia (PO2 < 5 mmHg) decreased vessel tone in isolated rat mesenteric arteries precontracted with either high [K+] or the thromboxane analogue U46619. This response was not altered by N-nitro-L-arginine (L-NA) and indomethacin. 2. Simultaneous measurement of pHi and tension showed that the decrease in vessel tone was accompanied by an intracellular acidification. Similar reductions in tone and pHi were observed with the metabolic inhibitors 2,4-dinitrophenol (DNP) and sodium azide. 3. The presence of the lactate transport inhibitor alpha-cyano-4-hydroxy-cinnamic acid (CHC) increased the magnitude of the acidification and resulted in a significantly faster reduction in tone in response to hypoxia. Addition of CHC to normoxic tissues caused both a vasodilatation and a reduction of pHi. 4. A decrease in pHi induced on washout of ammonium chloride (NH4Cl) resulted in an increase in tone. 5. Relaxation to hypoxia or metabolic inhibition was unaffected when the change in pHi was neutralized by addition of the weak base trimethylamine (TMA). 6. It is concluded that severe hypoxia decreases tone in isolated rat mesenteric arteries by a mechanism which is independent of nitric oxide and prostaglandins. Both severe hypoxia and metabolic inhibition reduced pHi, although this does not appear to be contributing to the changes in tone observed.  (+info)

TY - JOUR. T1 - The GPR55 agonist lysophosphatidylinositol relaxes rat mesenteric resistance artery and induces Ca2+ release in rat mesenteric artery endothelial cells. AU - Alsuleimani, Y. M.. AU - Hiley, C. R.. PY - 2015/6/1. Y1 - 2015/6/1. N2 - Background and Purpose Lysophosphatidylinositol (LPI), a lipid signalling molecule, activates GPR55 and elevates intracellular Ca2+. Here, we examine the actions of LPI in the rat resistance mesenteric artery and Ca2+ responses in endothelial cells isolated from the artery. Experimental Approach Vascular responses were studied using wire myographs. Single-cell fluorescence imaging was performed using a MetaFluor system. Hypotensive effects of LPI were assessed using a Biopac system. Key Results In isolated arteries, LPI-induced vasorelaxation was concentration- and endothelium-dependent and inhibited by CID 16020046, a GPR55 antagonist. The CB1 receptor antagonist AM 251 had no effect, whereas rimonabant and O-1918 significantly potentiated LPI ...
TY - JOUR. T1 - Assessing myogenic response and vasoactivity in resistance mesenteric arteries using pressure myography. AU - Jadeja, Ravirajsinh N.. AU - Rachakonda, Vikrant. AU - Bagi, Zsolt. AU - Khurana, Sandeep. PY - 2015/7/6. Y1 - 2015/7/6. N2 - Small resistance arteries constrict and dilate respectively in response to increased or decreased intraluminal pressure; this phenomenon known as myogenic response is a key regulator of local blood flow. In isobaric conditions small resistance arteries develop sustained constriction known as myogenic tone (MT), which is a major determinant of systemic vascular resistance (SVR). Hence, ex vivo pressurized preparations of small resistance arteries are major tools to study microvascular function in near-physiological states. To achieve this, a freshly isolated intact segment of a small resistance artery (diameter ~260 μm) is mounted onto two small glass cannulas and pressurized. These arterial preparations retain most in vivo characteristics and ...
We have investigated effects of altered extracellular sodium, intracellular sodium concentration, and membrane potential on the contractile responses of rat isolated mesenteric small arteries (internal diameter ca. 200 microns), when mounted as ring preparations on an isometric myograph. To avoid possible neural effects, all vessels were denervated in vitro using 6-hydroxydopamine. In unstimulated vessels, exposure to low-Na+ solutions (25 mM sodium, sucrose, or choline-substituted) did not cause any response nor did exposure to ouabain (1 mM) for 1 hour [when intracellular sodium concentration increased to 64 mmol/(liter-cell)]. However, a response was obtained if ouabain-exposed vessels were subjected to low-sodium solutions (ca. 15% of maximal response). The magnitude of the response was dependent on the ratio of intracellular to extracellular sodium and was not inhibitable by the calcium blockers, felodipine (1 nM) or D600 (10 microM). This response could therefore be explained in terms of ...
TY - JOUR. T1 - Mechanisms of vasorelaxation induced by oleoylethanolamide in the rat small mesenteric artery. AU - Alsuleimani, Yousuf M.. AU - Hiley, C. Robin. PY - 2013/2/28. Y1 - 2013/2/28. N2 - The actions of the anandamide-like mono-unsaturated fatty acid oleoylethanolamide (OEA) were first linked to satiety and control of food intake and recently reported to relax resistance vessels. This study characterizes its vasorelaxant mechanisms. Vasorelaxation to OEA were assessed in third order branches of rat superior mesenteric artery using a wire myograph. The roles of the endothelium, KCa channels, perivascular sensory nerves, NO, cannabinoid receptors, and the phospholipase C (PLC)/inositol trisphosphate (InsP3) and RhoA/ROCK signalling pathways, were assessed. OEA caused concentration- and endothelium-dependent vasorelaxation (pEC50=6.7±0.1, Rmax=93.1±2. 5%). L-NAME greatly reduced the response (residual relaxation of only 24.6±12.8%). Capsaicin and pertussis toxin significantly reduced ...
In WT mice, endothelium-dependent relaxations of small mesenteric arteries were mainly mediated by EDHF, whereas those of the aorta were mediated by NO, a finding that is consistent with our previous studies (2, 4, 14). Interestingly, EDHF-mediated relaxations were progressively reduced in accordance with the number of disrupted NOS genes in mesenteric arteries and were absent in n/i/eNOS−/− mice, indicating that EDHF-mediated relaxations are totally mediated by the endothelial NOSs system in mouse mesenteric arteries.. In this study, after the classical definition of EDHF (1-3), we evaluated EDHF-mediated responses in mouse mesenteric arteries in the presence of indomethacin and l-NNA. It is known that eNOS generates superoxide anions under normal conditions from reductase domain and only when uncoupled (e.g., BH4 and/or l-arginine depletion) from the oxidase domain, and that l-arginine analogues only inhibit the latter process (40). Indeed, we were able to demonstrate that endothelial ...
In the isolated canine mesenteric artery relaxation caused by nicorandil [N-(2-hydroxyethyl)nicotinamide nitrate ester; SG-75] in the presence of noradrenaline was accompanied by a concomitant...
1. In order to examine the effects of experimental hypertension on intracellular pH in mesenteric resistance arteries, intracellular pH was measured in mesenteric resistance arteries from rats with coarctation 72 h, 9 days and 28 days after the aorta was partially constricted between the origins of the renal arteries. Carotid arterial pressure was significantly raised at all time points.. 2. Second-order mesenteric resistance arteries were mounted in a myograph and were loaded with the acetoxymethyl ester of the pH-sensitive dye 2′,7′-bis(carboxyethyl)-5,6-carboxyfluorescein. Morphological measurements demonstrated that arteries from rats with coarctation had an increased media volume at 9 days and at 28 days compared with vessels from sham-operated control animals, but this was only statistically significant at 28 days.. 3. Resting intracellular pH was not significantly different at any time point in arteries from rats with coarctation compared with control animals, although there was a ...
1 the alpha(2)-adrenoceptor function in mesenteric arteries of spontaneously hypertensive rats (SHR) was investigated by comparing membrane potential changes in response to adrenergic agonists in preparations from female SHR, Wistar-Kyoto (WKY) and normotensive Wistar rats (NWR).2 Resting membrane potential was found to be less negative in mesenteric arteries from SHR than in those from NWR and WKY. Apamin induced a decrease in the membrane potential of mesenteric artery rings without endothelium from NWR and WKY, but had no effects in those from SHR. Both UK 14,304 and adrenaline, in the presence of prazosin, induced a hyperpolarization that was significantly lower in de-endothelialized mesenteric rings from SHR than in those from NWR and WKY. in mesenteric rings with endothelium, however, similar hyperpolarization was observed in the three strains.3 in NWR mesenteric rings with endothelium the hyperpolarization induced by activation of alpha(2)-adrenoceptors was abolished by apamin, whereas in ...
1. The properties of isolated 150-μm mesenteric resistance vessels from chemically denervated 5-month spontaneously hypertensive and normotensive Wistar-Kyoto rats have been examined.. 2. Chemical denervation reduced the blood pressure of both strains of rats, but the denervated spontaneously hypertensive rats were still hypertensive with respect to their denervated Wistar-Kyoto controls.. 3. Chemical denervation did not affect the morphological characteristics or calcium sensitivity of the resistance vessels.. 4. The results suggest that the media hypertrophy and increased calcium sensitivity seen in resistance vessels from non-denervated spontaneously hypertensive rats are intrinsic defects unrelated to either blood pressure or neurogenic influences. ...
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Downregulation of L-type Ca2+ channel in rat mesenteric arteries leads to loss of smooth muscle contractile phenotype and inward hypertrophic ...
article{b05afb58-252f-4a27-a2c1-eeed80e365a7, author = {Möller, Sebastian and Uddman, Erik and Welsh, Nicola and Edvinsson, Lars and Adner, Mikael}, issn = {1879-0712}, language = {eng}, number = {2-3}, pages = {209--215}, publisher = {Elsevier}, series = {European Journal of Pharmacology}, title = {Analysis of the time course for organ culture-induced endothelin ET(B) receptor upregulation in rat mesenteric arteries.}, url = {}, volume = {454}, year = {2002 ...
Methods Rat mesenteric arteries were mounted in a wire myograph and pre-constricted with U46619; cumulative concentration response curves were then constructed for the vasodilator responses to DHA (100 nM-30 µM). Blockade of NO PGI2 and endothelium dependent hyperpolarization (EDH) vasodilator pathways on DHA induced relation were assessed using pharmacological blockade. The effect of DHA on endothelium-dependent and independent relaxation produced by ACh and NONOate, respectively, was also assessed.. ...
Evidence is provided for expression and a functional role for phosphodiesterase type V (PDE-V) in the rat isolated small mesenteric artery. The reverse transcription polymerase chain reaction (RT--PCR) demonstrated mRNA for PDE-V, while Western blotting and immunocytochemical studies showed corresponding protein expression. Smooth muscle relaxation to the nitric oxide donor, diethylamine NONOate (DEA NONOate; 1 nM - 10 microM; pEC(50)=6.7+/-0.3) was potentiated significantly by the specific inhibitor of PDE-V, 4-[[3,4-(methylenedioxy)benzyl]amino]-6-chloroquinazoline (MBCQ; 1 microM; pEC(50)=10.5+/-0.04). These data show that PDE-V is expressed in both the smooth muscle and endothelial cells of a resistance artery, and the enzyme can significantly influence nitric oxide-evoked vasorelaxation.
Vascular thiol redox state has been shown to modulate vasodilator functions in large conductance Ca2+-activated K+ channels and other related channels. However, the role of vascular redox in small resistance arteries is unknown. To determine how in vivo modulation of thiol redox state affects small resistance arteries relaxation, we generated a transgenic mouse strain that overexpresses thioredoxin, a small redox protein (Trx-Tg), and another strain that is thioredoxin-deficient (dnTrx-Tg). The redox state of the mesenteric arteries (MAs) in Trx-Tg mice is found to be predominantly in reduced state; in contrast, MAs from dnTrx-Tg mice remain in oxidized state. Thus, we created an in vivo redox system of mice and isolated the second-order branches of the main superior MAs from wild-type, Trx-Tg, or dnTrx-Tg mice to assess endothelium-dependent relaxing responses in a wire myograph. In MAs isolated from Trx-Tg mice, we observed an enhanced intermediate-conductance Ca2+-activated potassium channel ...
Ligating to induce ischemia: ligate the feeding branch of the anterior mesenteric artery and the corresponding vein simultaneously with a snare created by 2-0 silk suture or polyethylene tube for 10 min. Both artery and vein were ligated to stop blood supply and induce venule congestion to enhance ischemia.Sham-operated rats without I/R were used as control ...
Rho-kinase expression was investigated in the rat mesenteric artery and the effects of its inhibitors, (+)-(R)-trans-4-(1-aminoethyl)-N(4-pyridyl) cyclohexanecarboxamide dihydrochloride monohydrate (Y-27632) and fasudil (HA-1077), were examined on the increase in perfusion pressure induced by two different receptor agonists, namely the alpha-adrenoceptor agonist, phenylephrine and, the endothelin ETA and ETB receptor agonist, endothelin-1. Y-27632 and fasudil produced a concentration-dependent decrease in perfusion pressure. There was no difference between the concentration -response lines of these two inhibitors. The maximum decrease in the perfusion pressure induced by 10(-5) M Y-27632 was 85.8 +/- 3.7% when the tone was increased by phenylephrine. However, it was 48.1 +/- 5.4% ( ...
Video articles in JoVE about mesenteric artery superior include Assessing Myogenic Response and Vasoactivity In Resistance Mesenteric Arteries Using Pressure Myography.
TY - JOUR. T1 - Endothelial cell facilitation of longitudinal spreading hyperpolarization and dilatation in rat isolated mesenteric artery. AU - Takano, H. AU - Dora, K A. AU - Garland, C J. PY - 2003. Y1 - 2003. M3 - Article. VL - 547P. SP - C109. JO - Journal of Physiology and Pharmacology. JF - Journal of Physiology and Pharmacology. SN - 0867-5910. ER - ...
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Affiliation:筑波大学,基礎医学系,講師, Research Field:General pharmacology,血管生物学, Keywords:エンドセリン,腸管膜動脈,神経ペプチド,血管拡張神経,冠血管,mesenteric artery,血管内皮細胞,CGRP,脳脊髄液,骨格筋, # of Research Projects:4, # of Research Products:0
TY - JOUR. T1 - Endothelial dysfunction in rat mesenteric resistance artery after transient middle cerebral artery occlusion. AU - Martinez-Revelles, Sonia. AU - Jiménez-Altayó, Francesc. AU - Caracuel, Laura. AU - Pérez-Asensio, Fernando J.. AU - Planas, Anna M.. AU - Vila, Elisabet. PY - 2008/1/1. Y1 - 2008/1/1. N2 - Stroke triggers a local and systemic inflammatory response leading to the production of cytokines that can influence blood vessel reactivity. In this study, we aimed to assess whether cerebral ischemia/reperfusion could affect vasoconstriction and vasodilatation on mesenteric resistance arteries (MRA) from Wistar Kyoto rats. The right middle cerebral artery was occluded (90 min) and reperfused (24 h). Sham-operated animals were used as controls. Plasma levels of interleukin (IL)-6 and IL-1β were measured at 24 h. Vasoconstrictor and vasodilator responses were recorded in a wire myograph. Protein expression was determined by Western blot and immunofluorescence, and superoxide ...
TY - JOUR. T1 - The contribution of d-tubocurarine-sensitive and Apamin-sensitive K-channels to EDHF-mediated Relaxation of Mesenteric Arteries from eNOS-/- Mice. AU - Chen, Xiaoliang. AU - Li, Yang. AU - Hollenberg, Morley. AU - Triggle, Christopher. AU - Ding, Hong. PY - 2012/5. Y1 - 2012/5. N2 - The nature of the potassium channels involved in determining endothelium-derived hyperpolarizing factor-mediated relaxation was investigated in first-order small mesenteric arteries from male endothelial nitric oxide synthase (eNOS-/-)-knockout and control (+/+) mice. Acetylcholine-induced endothelium-dependent relaxation of small mesenteric arteries of eNOS-/- was resistant to N-nitro-L-arginine and indomethacin and the guanylyl cyclase inhibitor, 1H-(1,2,4) oxadiazolo (4,3-a) quinoxalin-1-one. Apamin and the combination of apamin and iberiotoxin or apamin and charybdotoxin induced a transient endothelium-dependent contraction of small mesenteric arteries from both eNOS-/- and +/+ mice. ...
Increasing evidence shows that sex hormones exert a protective effect on the vasculature, especially in the regulation of the active vasomotor responses. However, whether sex hormones affect vascular remodelling is currently unclear. In the present study, we tested the hypothesis that testosterone in males and β-oestradiol in females prevent inward remodelling, possibly through inhibition of cross-linking activity induced by enzymes of the TG (transglutaminase) family. Small mesenteric arteries were isolated from male and female Wistar rats. Dose-dependent relaxation to testosterone and β-oestradiol was inhibited by the NO synthase inhibitor L-NAME (NG-nitro-L-arginine methyl ester), confirming that these hormones induce NO release. When arteries were cannulated, pressurized and kept in organ culture with ET-1 (endothelin-1) for 3 days we observed strong vasoconstriction and inward remodelling. Remodelling was significantly inhibited by testosterone in males, and by β-oestradiol in females. ...
Many studies in recent years have implicated an altered microvascular structure in the genesis and maintenance of hypertension.4 5 6 7 8 9 10 11 In the present study we have provided further evidence that resistance arteries from genetically hypertensive rats have a reduced internal diameter compared with arteries from their normotensive controls. In order to do this, we used a pressure myograph. This technique has the advantage that it allows arteries to assume the stereological conformation they would attain in vivo,12 13 in contrast to some other methodologies used for examining resistance artery structure, such as wire myography.13 The media-to-lumen ratio of resistance arteries from DI/H rats was increased compared with DI/N controls. Although this could be taken as evidence for vascular growth, there was no difference in media cross-sectional surface area in arteries from DI/N and DI/H rats. Our results suggest, therefore, that the architecture of the mesenteric vasculature in DI/H rats ...
The novel findings of the present investigation in pressurized rat resistance mesenteric arteries with endothelium include the following: (1) raloxifene at therapeutically achievable concentrations reduces myogenic constriction in a concentration-dependent manner; (2) dilatations to raloxifene are rapid and nongenomic in nature, unrelated to ICI 182,780-sensitive estrogen receptor; (3) endothelium-derived NO accounts in large part for raloxifene-induced dilatations, as they are inhibited by l-NAME; (4) eNOS activation is causally controlled by Ca2+ influx stimulated by raloxifene without involving PI3K/Akt-related mechanisms; (5) raloxifene dose not modulate CTX/apamin-sensitive endothelium-derived hyperpolarizing factor-mediated dilatations; and (6) there is a marked gender difference in dilator responses to raloxifene, which is more effective on female arteries. The present study has provided the first line of experimental evidence exhibiting a potent vasodilating effect of raloxifene in ...
The objective of this study was to evaluate the changes in vascular reactivity of mesenteric arteries resulting from hyperbaric oxygen treatment. It was hypothesized that hyperbaric oxygen treatment alters vascular reactivity in mesenteric arteries due to enhanced production of ATP resulting in significantly larger responses to vasoactive stimuli. All arteries were dissected from porcine mesenteries and placed in Krebs- Henseleit solution. Arteries were initially mounted in isolated organ baths and passively loaded with tensions ranging from 1 to 25 grams at odd intervals to ascertain the optimal passive tension for studying mesenteric arteries. Following a 1-hour equilibration in Krebs-Henseleit solution, arteries were treated with potassium chloride (a nonreceptormediated vasoconstrictor; KCl; 15 - 60 mM) to assess vascular reactivity. Following determination of the optimal passive tension, additional arteries were dissected and tested for viability with KCl. Viable arteries were then subjected to a 2
Trykk myography brukes til å vurdere vasoactivity av små arterier som utvikler vedvarende innsnevring når trykk. Dette manuskriptet...
Yamawaki H, Sato K, Hori M, Ozaki H, Nakamura S, Nakayama H, Doi K, Karaki H. Impairment of EDR by a long-term PDGF treatment in organ-cultured rabbit mesenteric artery. Am J Physiol. 1999 07; 277(1):H318-23 ...
TY - JOUR. T1 - Gender differences in the effect of age on electrical field stimulation (EFS)-induced adrenergic vasoconstriction in rat mesenteric resistance arteries. AU - Sullivan, Jennifer C. AU - Davison, Cathy A.. PY - 2001/3/14. Y1 - 2001/3/14. N2 - The objective of this study was to examine the effects of gender and age on electrical field stimulation (EFS)-induced vasoconstriction. Fisher 344 rats were studied: young females (YF, n = 38), young males (YM, n = 29), old females (OF, n = 33), and old males (OM, n = 30). Isolated mesenteric resistance arteries (endothelium-intact or denuded) were pressurized, and outer diameter was monitored. Dose-response curves were performed to KCl and phenylephrine (PE). EFS (0.1-16 Hz) responses were expressed as percentage of constriction from baseline. Area under the curve (AUC) was calculated and comparisons were made using analysis of variance and t tests. Females became less responsive to EFS-induced constriction with age, whereas constrictor ...
Transient receptor potential (TRP) channels contribute to endothelial cytosolic calcium signaling. Roles for both transient receptor potential C3 (TRPC3) and vallinoid type4 (TRPV4) in agonist-evoked endothelium-dependent vascular relaxation have been proposed. Thus, in this study we have investigated the functional contribution of these channels to endothelium-dependent modulation of phenylephrine- and nerve-evoked increases in tone and to acetylcholine-evoked relaxation in rat mesenteric arteries. Using an immunohistochemical approach, TRPC3 and TRPV4 antibodies showed low level diffuse and punctate labeling in endothelial cells and absence in smooth muscle cells. 1-[4- [(2,3,3-Trichloro-1-oxo-2-propen-1-yl)amino]phenyl]-5- (trifluoromethyl)-1H-pyrazole-4-carboxylic acid (Pyr3), a selective inhibitor of TRPC3 channels enhanced nerve- and phenylephrine-induced increases in tone in endotheliumintact arteries but was without effect on acetylcholine-evoked relaxations. 1-(4-chloro-2-nitrophenyl) sulfonyl
In rat mesenteric arteries, the ability of ACh to evoke hyperpolarization of smooth muscle cells and consummate dilatation relies on an increase in endothelial cell cytosolic free [Ca2+] and activation of Ca2+-activated K+ channels (KCa). The time course of average and spatially organized rises in endothelial cell [Ca2+]i and concomitant effects on membrane potential were investigated in individual cells of pressurized arteries and isolated sheets of native cells stimulated with ACh. In both cases, ACh stimulated a sustained and oscillating rise in endothelial cell [Ca2+]i. Overall, the oscillations remained asynchronous between cells, yet occasionally localized intercellular coordination became evident. In pressurized arteries, repetitive waves of Ca2+ moved longitudinally across endothelial cells, and depended on Ca2+-store refilling. The rise in endothelial cell Ca2+ was associated with sustained hyperpolarization of endothelial cells in both preparations. This hyperpolarization was also evident when
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In rats with chronic neurogenic hypertension induced by sinoaortic baroreceptors denervation (SAD), dl-[3H]norepinephrine (dl-[3H]NE) release, metabolism and vascular response to nerve stimulation were studied in isolated perfused mesenteric arteries. Thirty weeks after SAD, systolic arterial pressure was increased and, in isolated mesenteric arteries, vascular resistance, vascular response to nerve stimulation and responses to exogenous NE were higher in hypertensive than in sham-operated normotensive rats. However, in the isolated mesenteric arteries labeled with dl-[3H]NE, the total increase in radioactivity elicited by nerve stimulation was similar in both SAD and sham-operated groups. Unmetabolized [3H]NE released in mesenteric arteries was higher than that observed in other peripheral noradrenergic tissues (such as cat nictitating membrane, cat spleen, guinea-pig atria) and deaminated glycol 3,4-dihydroxyphenylglycol was the main metabolite of [3H]NE released by nerve stimulation from the ...
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n either of two arteries arising from the aorta and passing between the two layers of the mesentery to the intestine: a) one that arises just above the bifurcation of the abdominal aorta into the common iliac arteries and supplies the left half…
Learn about diseases of the arteries to the kidneys and intestines, including diagnostic tests, and minimally invasive and traditional surgery treatments.
Results: Intrathecal injection of TRPV1 shRNA (6 μg kg−1 per day) for 3 days increased systolic blood pressure and MAP when compared to rats that received control shRNA (control shRNA: 112±2 vs TRPV1 shRNA: 123±2 mmHg). TRPV1 expression was suppressed in T8-L3 segments of dorsal horn and DRG as well as mesenteric arteries of rats given TRPV1 shRNA. Contents of tyrosine hydroxylase, a marker of sympathetic nerves, were increased in mesenteric arteries of rats treated with TRPV1 shRNA. Pretreatment with the 1-adrenoceptor blocker, prazosin (1 mg/kg/day, p.o.), abolished the TRPV1 shRNA-induced pressor effects ...
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Small artery function 2 years postpartum in women with altered glycaemic distributions in their preceding pregnancy Academic Article ...
In this study, our aims were to investigate transient receptor potential melastatin-8 channels (TRPM8) involvement in rotundifolone induced relaxation in the mesenteric artery and to increase the understanding of the role of these thermosensitive TRP channels in vascular tissue. Thus, message and protein levels of TRPM8 were measured by semi-quantitative PCR and western blotting in superior mesenteric arteries from 12 week-old Spague-Dawley (SD) rats. Isometric tension recordings evaluated the relaxant response in mesenteric rings were also performed. Additionally, the intracellular Ca2+ changes in mesenteric artery myocytes were measured using confocal microscopy. Using PCR and western blotting, both TRPM8 channel mRNA and protein expression was measured in SD rat mesenteric artery. Rotundifolone and menthol induced relaxation in the isolated superior mesenteric artery from SD rats and improved the relaxant response induced by cool temperatures. Also, this monoterpene induced an increase in transient
TY - JOUR. T1 - Inducible nitric oxide synthase-derived superoxide contributes to hypereactivity in small mesenteric arteries from a rat model of chronic heart failure. AU - Miller, A A. AU - Megson, I L. AU - Gray, G A. PY - 2000. Y1 - 2000. N2 - The aims of this study were to (a) determine whether inducible nitric oxide synthase (iNOS) is expressed in small mesenteric arteries from rats with chronic heart failure (CHF), (b) investigate the functional significance of this potential source of nitric oxide (NO) on vascular responsiveness and (c) investigate the role that superoxide plays in modulating vascular function in these arteries. CHF was induced in male Wistar rats by coronary artery ligation (CAL). In sham-operated rats the ligature was not tied but pulled under the artery. Six weeks after surgery CAL rats had left ventricular (LV) infarctions and elevated LV end-diastolic pressures. Immunoreactive iNOS was found in endothelial cells, vascular smooth muscle cells and in the adventitia of ...
The superior mesenteric artery is a major blood vessel in the digestive system. This artery branches off the abdominal aorta and supplies oxygenated blood to the pancreas and the lower parts of the intestine. This includes the lower duodenum, as well as transverse colon.
New pharmacotherapies are required to improve vessel graft protection and prevent vasoconstriction and spasm in CABG surgery. Previously we have studied adenosine (A) and lidocaine (L) relaxation in rat aortic rings, and reported a possible crosstalk between L relaxation and adenosine A(2a) receptor inhibition. The aim of the present study was to examine the effect of AL combination compared to A and L alone on relaxation in intact and denuded rat aortic rings and in guinea-pig pressurized mesenteric arterial segments. Aortic rings were harvested from Sprague-Dawley rats and equilibrated in an organ bath containing modified Krebs-Henseleit (KH) solution, pH 7.4, 37 degrees C. Rings were pre-contracted sub-maximally with 0.3 mu M norepinephrine, and the effects of increasing AL, A or L (up to 1.0 mM) were examined in intact and denuded rings. Mesenteric artery segments were isolated from guinea-pigs and mounted in an arteriograph containing KH solution and pressurised to 60 mmHg. Arteries were ...
Retrograde superior mesenteric artery stenting (ROMS) represents a significant development in the treatment of acute mesenteric ischemia. Compared to traditional surgical mesenteric bypass, ROMS is a less invasive technique that avoids many complicat
Approach and Results-Real-time polymerase chain reaction, immunohistochemistry, and Western analyses supported the synthesis and expression of chemerin in perivascular adipose tissue, whereas the primary chemerin receptor ChemR23 was expressed both in the tunica media and endothelial layer. The ChemR23 agonist chemerin-9 caused receptor, concentration-dependent contraction in the isolated rat thoracic aorta, superior mesenteric artery, and mesenteric resistance artery, and contraction was significantly amplified (more than 100%) when nitric oxide synthase was inhibited and the endothelial cell mechanically removed or tone was placed on the arteries. The novel ChemR23 antagonist CCX832 inhibited phenylephrine-induced and prostaglandin F2α-induced contraction (+perivascular adipose tissue), suggesting that endogenous chemerin contributes to contraction. Arteries from animals with dysfunctional endothelium (obese or hypertensive) demonstrated a pronounced contraction to chemerin-9. Finally, ...
The inferior mesenteric artery (IMA) brings oxygen-rich blood to the large intestine, specifically to the upper region of the rectum and the left colic flexure, a bend at the intestines left side. The upper part of the rectum should not be confused with the anus itself.
Inferior mesenteric artery angiogram (bottom image) and subsequent venous phase image (top image)demonstrates pooling of contrast material in the splenic flexur
In the current study, we found that type 2 diabetes impaired the ability of mesenteric arteries to remodel and improve NO-dependent dilation in response to a chronic increase in blood flow. Indeed, AGEs and RAGEs were overexpressed, whereas eNOS level and MMP activity were reduced in arteries from ZDF rats. Ongoing treatment with the AGE-breaker ALT-711 restored the ability of mesenteric arteries from ZDF rats to increase their diameter and improved endothelium-dependent dilation in response to a chronic rise in blood flow.. Physiologically, a chronic rise in blood flow in resistance arteries enlarges vascular diameter and improves endothelium-dependent dilation (9,19,34). This remodeling is essential to adjust organ perfusion during physiological processes, such as development (35), pregnancy (36), or exercise training (37), as well as during pathological processes (mainly ischemic diseases). A similar remodeling also occurs in response to vasodilator treatments (38,39). This remodeling plays a ...
The Arteriograph is a diagnostic instrument which is able to measure the severity of arteriosclerosis. This is the condition of arterial blockage caused by inflammation or damage within arteries followed by an over production of a compound known as plaque created by the body to repair the damage. Plaque is made up of cholesterol, minerals such as calcium, specialised red blood cells known as platelets and other clotting factors. The Arteriograph is a simple and painless, non invasive investigation that can diagnose arteriosclerosis at an early stage . Symptoms of arterial blockage include chest pain from blocking heart arteries, or the loss of sensation, numbness, or cramp in the lower limbs as the leg arteries block. These symptoms tend not to occur until a considerable amount of an artery is blocked and other arteries are no longer able to offer effective collateral circulation. Symptoms of cardiovascular disease leading to heart attacks and strokes usually appear only in the last and late ...
A 56--year-old man pre-sented -with com-plete occlu-sion of the -superior and infe-rior mes-en-teric -arteries -resulting in -chronic mes-en-teric -ischemia. -After a min-imal angio-plasty a Wall-stent was -inserted -across the -superior mes-en-teric -artery occlu-sion. -This pro-duced imme-diate clin-ical -relief, -with a suc-cessful angio-graphic -result. -Eight -months -later, an intra-stent occlu-sion -with -acute -bowel infarc-tion was -treated in emer-gency by saph-e-nous -vein -bypass -graft. -Despite the -death of the -patient a few -days -later -from a -multivis-ceral -failure syn-drome, -this -method -seemed to us fea-sible in -treating a chron-i-cally -occluded SMA in -patients -with -high oper-a-tive -risk.. ...
Details of the image Enlarged arc of Riolan and marginal artery of Drummond secondary to occluded coeliac axis and superior mesenteric artery Modality: CT (C+ arterial phase)
The pharmacological effects on the cardiovascular system of yangambin, a lignan isolated from Ocotea duckei Vattimo (Lauraceae), were studied in rats using combined functional and biochemical approaches. In non-anaesthetized rats, yangambin (1, 5, 10, 20, 30 mg/kg, i.v.) induced hypotension (−3.5 ± 0.2; −7.1 ± 0.8; −8.9 ± 1.3; −14 ± 2.3, −25.5% ± 2.6%, respectively) accompanied by tachycardia (5.9 ± 0.5; 5.9 ± 1.6; 8.8 ± 1.4; 11.6, 18.8% ± 3.4%, respectively). In isolated rat atria, yangambin (0.1 µM-1 mM) had very slight negative inotropic (Emax = 35.6% ± 6.4%) and chronotropic effects (Emax = 10.2% ± 2.9%). In endothelium-intact rat mesenteric artery, yangambin (0.1 µM-1 mM) induced concentration-dependent relaxation (pD2 = 4.5 ± 0.06) of contractions induced by phenylephrine and this effect was not affected by removal of the endothelium. Interestingly, like nifedipine, the relaxant effect induced by yangambin was more potent on the contractile response induced by KCl 80 mM
Vascular Disturbances A frequent misconception, despite abundant experience to the contrary, is that pain associated with intraabdominal vascular disturbances is sudden and catastrophic in nature. The pain of embolism or thrombosis of the superior mesenteric artery or that of impending rupture of an abdominal aortic aneurysm certainly may be severe and diffuse. Yet, just as frequently, the patient with occlusion of the superior mesenteric artery has only mild continuous diffuse pain for 2 or 3 days before vascular collapse or findings of peritoneal inflammation appear. ...
A review of the clinical presentation and sonographic diagnosis of mesenteric artery ischemia. Mesenteric artery insufficiency, Other mesenteric pathologies, Stents, Surgical management.
J Pediatr Orthop. 2018 Apr 17.. Spontaneous and isolated dissection of the superior mesenteric artery: proposal of a management algorithm. ROUSSEL A, PELLENC Q, CERCEAU P, TRESSON P, HOUBBALAH R, FRANCIS F, PARASKEVAS N, LESECHE G, CORCOS O, PASI N, CASTIER Y ...
Sigma-Aldrich offers abstracts and full-text articles by [Xianming Su, Xiaowen Zhi, Ting Cui, Qiaowei Zheng, Shixiang Wang, Yongxiao Cao, Changcong Cui, Weiyi Feng].
Results: Intrathecal injection of TRPV1 shRNA (6 μg kg−1 per day) for 3 days increased systolic blood pressure and MAP when compared to rats that received control shRNA (control shRNA: 112±2 vs TRPV1 shRNA: 123±2 mmHg). TRPV1 expression was suppressed in T8-L3 segments of dorsal horn and DRG as well as mesenteric arteries of rats given TRPV1 shRNA. Contents of tyrosine hydroxylase, a marker of sympathetic nerves, were increased in mesenteric arteries of rats treated with TRPV1 shRNA. Pretreatment with the 1-adrenoceptor blocker, prazosin (1 mg/kg/day, p.o.), abolished the TRPV1 shRNA-induced pressor effects ...
Free, official coding info for 2018 ICD-10-CM S35.291A - includes detailed rules, notes, synonyms, ICD-9-CM conversion, index and annotation crosswalks, DRG grouping and more.
Telezhkin, V. S., Yarova, P. L., Garland, C. J. and Dora, K. A., 2007. Isolated endothelial cells from rat mesenteric artery display spontaneous outward currents. In: The Physiological Society Meeting: Ion Channels and the Microcirculation ...
Inducible change in the behavior of resistance arteries from circulating factor in preeclampsia: an effect specific to myometrial vessels from pregnant women
CONFOCAL WIRE MYOGRAPH SYSTEM - 360CW-China Gate Scientific (Shanghai) Co.,Ltd-DMT360CW is specially designed to provide very close optical access to the mounted artery or tissue segment, thereby allowing high resolution images of fluorescent dyes or LSCM.
An organs larger arteries and veins flow between its functional units. Often there is a generous amount of loose fibrous tissue separating an artery and the business cells of the organ. If youre interested in the layers of the arteries, they are: Intima: Inner layer, the endothelium, a bit of collagen, and perhaps a few other inconspicuous cells. Media: Middle layer, composed of smooth muscle oriented circumferentially. Adventitia: Fibrous tissue, merging with the surrounding fibrous tissue of the organ. ...
Superior mesenteric artery Inferior mesenteric artery Gray, Henry (1918). "5a. 2. The Abdominal Aorta". Anatomy of the Human ... Both the superior and inferior mesenteric arteries arise from the abdominal aorta. Each of these arteries travel through the ... branches of these arteries join with the marginal artery of the colon, which means that occlusion of one of the main arteries ... The mesenteric arteries take blood from the aorta and distribute it to a large portion of the gastrointestinal tract. ...
... and therefore the superior mesenteric artery. The SMA and IMA anastomose via the marginal artery of the colon (artery of ... Front of abdomen, showing surface markings for arteries and inguinal canal. Inferior mesenteric artery Lumbar and sacral plexus ... The inferior mesenteric artery and its branches. Abdominal portion of the sympathetic trunk, with the celiac plexus and ... In human anatomy, the inferior mesenteric artery, often abbreviated as IMA, is the third main branch of the abdominal aorta and ...
... Dissection showing the anatomical relationship between the superior mesenteric artery and ... This artery is completed by branches of the left colic which is a branch of the inferior mesenteric artery. Compared to other ... In human anatomy, the superior mesenteric artery (SMA) is an artery which arises from the anterior surface of the abdominal ... Located under this portion of the superior mesenteric artery, between it and the aorta, are the following: left renal vein - ...
Superior mesenteric artery (SMA) syndrome is a gastro-vascular disorder in which the third and final portion of the duodenum is ... "Superior mesenteric artery syndrome". Archived from the original on 2008-10-25. Yang WL, Zhang XC (January ... "Superior Mesenteric Artery Syndrome". Retrieved 2014-10-12. Lippl F, Hannig C, Weiss W, Allescher HD, Classen ... October 2007). "Superior mesenteric artery syndrome in an infant: case report and literature review". Journal of Pediatric ...
Kornmehl, P.; Weizman, Z.; Liss, Z.; Bar-Ziv, J.; Joseph, A. (1988). "Superior mesenteric artery syndrome presenting as an ... It was subsequently proven to be MNGIE superior mesenteric artery syndrome (SMA syndrome) "is a gastrointestinal disorder ... "Superior Mesenteric Artery Syndrome". Digestive Surgery. 26 (3): 213-214. doi:10.1159/000219330. PMID 19468230. ... by the compression of the third or transverse portion of the duodenum against the aorta by the superior mesenteric artery ...
"Superior mesenteric artery syndrome , Radiology Reference Article ,". Radiopaedia. Retrieved 2020-11-11. Rueff ... However, the main causes are: Annular pancreas Adhesions Systemic sclerosis Superior mesenteric artery syndrome Aneurysm. ...
Opie, EL; Lynch, CJ; Tershakovec, M (April 1970). "Sclerosis of the mesenteric arteries of rats. Its relation to longevity and ...
... it receives dual blood supply from the terminal branches of the superior mesenteric artery and the inferior mesenteric artery, ... receives dual blood supply from the terminal branches of the superior mesenteric artery and the inferior mesenteric artery. The ... It receives blood supply from the superior mesenteric artery. The left colic flexure or splenic flexure (as it is close to the ...
The right colic artery is an artery of the abdomen. It is a branch of the superior mesenteric artery. It supplies the ascending ... The right colic artery is a branch of the superior mesenteric artery. It may arise from about the middle of the concavity, or ... If part of the superior mesenteric artery is missing due to a congenital abnormality, the right colic artery may supply part of ... Ligation is performed close to the origin of the right colic artery from the superior mesenteric artery. ...
... artery Right colic artery Middle colic artery Left colic artery The first three are branches of the superior mesenteric artery ... Colic artery (an artery that serves the colon) may refer to the: Ileocolic ... the fourth is a branch of the inferior mesenteric artery. This disambiguation page lists articles associated with the title ... Colic artery. If an internal link led you here, you may wish to change the link to point directly to the intended article. ( ...
... is supplied by the most distal portions of both the inferior mesenteric artery and superior mesenteric artery, and is thus ... The superior mesenteric artery supplies:[citation needed] Small bowel Ascending and proximal two-thirds of the transverse colon ... Arterial supply to the intestines is provided by the superior and inferior mesenteric arteries (SMA and IMA respectively), both ... Skinner, Dylan; Wehrle, Chase J.; Fossen, Kelly Van (10 August 2020). "Anatomy, Abdomen and Pelvis, Inferior Mesenteric Artery ...
Busquet J (1997). "Intravascular stenting in the superior mesenteric artery for chronic abdominal angina". Journal of ... "Transient relief of abdominal angina by Wallstent placement into an occluded superior mesenteric artery". The Journal of ... Abdominal pain Ischemic colitis Kapadia S, Parakh R, Grover T, Agarwal S (2005). "Side-to-side aorto-mesenteric anastomosis for ... a type of chest pain due to obstruction of the coronary artery), angina by itself can also mean "any spasmodic, choking, or ...
... which is the mesenteric arterial connection between the superior and inferior mesenteric arteries. Marginal fibers of the ... A literature survey of the connection(s) between the superior and inferior mesenteric arteries". The American Journal of ... van Gulik, Thomas M. (1 December 2005). "Anastomosis of Riolan Revisited: The Meandering Mesenteric Artery". Archives of ...
"Mechanism of the vasodilator effect of Euxanthone in rat small mesenteric arteries". Phytomedicine. 17 (8-9): 690-692. doi: ...
The middle colic artery is an artery of the abdomen. It is a branch of the superior mesenteric artery that mostly supplies the ... The middle colic artery is a branch of the superior mesenteric artery. It arises just below the pancreas. It passes inferiorly ... The left anastomoses with the left colic artery, a branch of the inferior mesenteric artery (forming the arc of Riolan). This ... The middle colic artery may rarely originate from the splenic artery. An extra accessory middle colic artery can be found in ...
The superior rectal artery is the continuation of the inferior mesenteric artery. It descends into the pelvis between the ... The superior rectal artery (superior hemorrhoidal artery) is an artery that descends into the pelvis to supply blood to the ... and communicate with the middle rectal artery (from the internal iliac artery) and with the inferior rectal artery (from the ... Middle rectal artery Inferior rectal artery This article incorporates text in the public domain from page 610 of the 20th ...
The rectum receives blood from both the inferior mesenteric artery and the internal iliac artery; the rectum is rarely involved ... The colon receives blood from both the superior and inferior mesenteric arteries. The blood supply from these two major ... In a 1991 review concerning 2137 patients the accidental inferior mesenteric artery ligation was the most common cause (74%) of ... The complication can be prevented through careful selection of subjects that may require replanting inferior mesenteric artery ...
The inferior pancreaticoduodenal artery (the IPDA) is a branch of the superior mesenteric artery. It supplies the head of the ... The inferior pancreaticoduodenal artery is a branch of the superior mesenteric artery. This occurs opposite the upper border of ... The inferior pancreaticoduodenal artery may branch from the first intestinal branch of the superior mesenteric artery rather ... "Coil embolization of an inferior pancreaticoduodenal artery aneurysm associated with celiac artery occlusion". Cardiovascular ...
Superior mesenteric artery Intestinal arteries of the superior mesenteric artery.Plastination technique . This article ... The intestinal arteries arise from the convex side of the superior mesenteric artery. They are usually from twelve to fifteen ... The large intestine is primarily supplied by the right colic artery, middle colic artery, and left colic artery. They do not ... The term "intestinal arteries" can be confusing, because these arteries only serve a small portion of the intestines. They do ...
This antagonistic activity was responsible for the ability of 12(S)-HETE and 12(R)-HETE to relax mouse mesenteric arteries pre- ... 12(S)-HETE and 12(S)-HpETE stimulate the dilation of rat mesenteric arteries; 12(S)-HETE stimulates the dilation of coronary ... The vasodilating effect on mouse mesenteric arteries appears due to 12S-HETE's ability to act as a Thromboxane receptor ... "Impaired arachidonic acid-mediated dilation of small mesenteric arteries in Zucker diabetic fatty rats". AJP: Heart and ...
The inferior pancreaticoduodenal artery is a branch of the superior mesenteric artery. These arteries, together with the ... The superior pancreaticoduodenal artery is an artery that supplies blood to the duodenum and pancreas. It is a branch of the ... At 42 letters, the posterior superior pancreaticoduodenal artery is also the artery with the longest name in the human body.[ ... although there are numerous variations of the origin of the gastroduodenal artery. The pancreaticoduodenal artery divides into ...
Because of collateral blood flow from the superior mesenteric artery (SMA) via the marginal artery, the inferior mesenteric ... from the left subclavian to below the renal artery; Extent III, from the sixth intercostal space to below the renal artery; and ... extending from the left subclavian artery to just below the renal artery; Extent II, ... Disease of the aorta proximal to the left subclavian artery in the chest lies within the specialty of cardiac surgery, and is ...
... celiac artery) and superior mesenteric artery, passes behind the pancreas, and enters the upper part of the mesentery, ... and duodenojejunal flexure to connective tissue surrounding the superior mesenteric artery and coeliac artery. It is also known ... Superior mesenteric artery syndrome is a rare abnormality caused by a congenitally short suspensory muscle. The duodenum and ... Superior mesenteric artery syndrome (SMA) is an extremely rare life-threatening condition that can either be congenital and ...
Anorexia nervosa Conatus , Wiktionary Metabolism Starvation Superior mesenteric artery syndrome Wasting "Metabolic Pathways , ...
Lymph from the midgut drains to prevertebral superior mesenteric nodes located at the origin of the superior mesenteric artery ... After it bends around the superior mesenteric artery, it is called the "midgut loop". It comprises the portion of the ... Arterial supply to the midgut is from the superior mesenteric artery, an unpaired branch of the aorta. Venous drainage is to ... Parasympathetic innervation of the midgut is from the superior mesenteric plexus, while sympathetic innervation is from the ...
Arterial supply to the colon comes from branches of the superior mesenteric artery (SMA) and inferior mesenteric artery (IMA). ... a branch of the superior mesenteric artery (SMA), while the latter third is supplied by branches of the inferior mesenteric ... A literature survey of the connection(s) between the superior and inferior mesenteric arteries". Am J Surg. 193 (6): 742-748. ... Historically, a structure variously identified as the arc of Riolan or meandering mesenteric artery (of Moskowitz) was thought ...
They give rise to the celiac artery, superior mesenteric artery, and inferior mesenteric artery. "vitelline arteries ( ... The vitelline arteries are the arterial counterpart to the vitelline veins. Like the veins, they play an important role in the ...
It lies close to the origin of the superior mesenteric artery. The superior mesenteric ganglion is the synapsing point for one ... The superior mesenteric ganglion is a ganglion in the upper part of the superior mesenteric plexus. ... Specifically, contributions to the superior mesenteric ganglion arise from the lesser splanchnic nerve, which typically arises ...
The jejunum and ileum receive blood from the superior mesenteric artery. Branches of the superior mesenteric artery form a ... Mesenteric ischemia Embolus or thrombus of the superior mesenteric artery or the superior mesenteric vein Arteriovenous ... via the superior pancreaticoduodenal artery and from the superior mesenteric artery via the inferior pancreaticoduodenal artery ... The small intestine receives a blood supply from the celiac trunk and the superior mesenteric artery. These are both branches ...
... showing distribution of branches of inferior mesenteric artery and their anastomoses. Middle rectal artery Superior rectal ... The middle rectal artery is an artery in the pelvis that supplies blood to the rectum. The middle rectal artery usually arises ... It anastomoses with the inferior vesical artery, superior rectal artery, and inferior rectal artery. In males, the middle ... In females, the middle rectal artery gives off branches to the vagina. The middle rectal artery supplies the rectum above the ...
Complications may include seizures, disseminated intravascular coagulopathy, mesenteric artery occlusion, or rhabdomyolysis. ...
As well as peptic ulcers, vomiting blood may result from abnormal arteries or veins that have ruptured, including Dieulafoy's ... Acute conditions affecting the bowels include infectious diarrhea and mesenteric ischaemia. Causes of constipation may include ...
Damage to mesenteric arteries can cause abdominal pain, mesenteric ischemia, and bowel perforation. Abdominal pain may also be ... affecting medium-sized muscular arteries, typically involving the arteries of the kidneys and other internal organs but ... Involvement of the renal artery, which supplies the kidneys with highly oxygenated blood, often leads to high blood pressure in ... Mononeuritis multiplex develops in more than 70% of patients with polyarteritis nodosa because of damage to arteries supplying ...
... can refer to: Superior mesenteric artery Superior mesenteric vein Superior mesenteric lymph nodes Superior ... mesenteric ganglion This disambiguation page lists articles associated with the title Superior mesenteric. If an internal link ...
... which are all part of the same mesenteric sheet, are often nebulous. The right and left gastroepiploic arteries (also known as ... The right gastroepiploic artery is a branch of the gastroduodenal artery, which is a branch of the common hepatic artery, which ... The left gastroepiploic artery is the largest branch of the splenic artery, which is a branch of the celiac trunk. The right ... The celiac artery and its branches; the liver has been raised, and the lesser omentum and anterior layer of the greater omentum ...
... mesenteric, and coronary arteries. to cause a reduction in systemic vascular resistance. Fenoldopam has a rapid onset of action ... Hughes AD, Sever PS (1989). "Action of fenoldopam, a selective dopamine (DA1) receptor agonist, on isolated human arteries". ...
The inferior mesenteric ganglion is a ganglion located near where the inferior mesenteric artery branches from the abdominal ... Sympathetic (red) and parasympathetic (blue) nervous system Superior mesenteric ganglion This article incorporates text in the ...
... artery In case of a coarctation of the aorta located between the celiac trunk and the superior mesenteric artery, the ... Pancreaticoduodenal artery (arteries to the pancreas and duodenum) can refer to: Superior pancreaticoduodenal artery Inferior ... This disambiguation page lists articles associated with the title Pancreaticoduodenal artery. If an internal link led you here ... anastomosis between these arteries can provide an alternative route for blood flow, called the pancreaticoduodenal arcade. ...
... or bleeding from the pancreatic duct Severe superior mesenteric artery syndrome The diagnosis of upper gastrointestinal ...
Gadkari TV, Cortes N, Madrasi K, Tsoukias NM, Joshi MS (November 2013). "Agmatine induced NO dependent rat mesenteric artery ...
The sigmoid arteries are 2-5 branches of the inferior mesenteric artery that are distributed to the distal descending colon and ... Branches of the Inferior Mesenteric Artery" Anatomy image:7926 at the SUNY Downstate Medical Center Portal: Anatomy v t e (CS1 ... 1197 The sigmoid arteries anastomose with the left colic superiorly, and with the superior rectal artery inferiorly. Gray's ... the sigmoid colon.: 1197 The sigmoid arteries course obliquely inferior-ward and to the left, passing posterior to the ...
... including the umbilical arteries and vein. The differential vasoconstriction of these fetal vessels compared to the vasodilator ... receptor expression and leukocyte trafficking across mouse mesenteric postcapillary venules". The Journal of Experimental ...
... should continue if the person with a LGIB underwent stenting of the heart's coronary arteries within the last 30 days or a ... specifically a bleeding diathesis Anal fissures Rectal foreign bodies Mesenteric ischemia NSAIDs Entamoeba histolytica ...
... artery Superior laryngeal artery Superior lateral genicular artery Superior medial genicular artery Superior mesenteric artery ... Superior artery may refer to Anterior superior alveolar arteries Posterior superior alveolar artery Superior alveolar artery ( ... Superior phrenic arteries Superior rectal artery Superior thoracic artery Superior thyroid artery Superior suprarenal artery ... cerebellar artery Superior epigastric artery Superior genicular arteries Superior gluteal artery Superior hypophysial artery ...
... superior mesenteric artery, and renal arteries branch from the abdominal aorta. It is behind the stomach and the omental bursa ... ovarian plexus Superior mesenteric plexus The celiac plexus is often popularly referred to as the solar plexus. In the context ...
In rat mesenteric artery, KCNE4 augments KCNQ4 channel activity to regulate arterial tone. A single polymorphism in the KCNE4 ... KCNE4 has no known effect on KCNQ2, KCNQ3 or KCNQ5 channels, but augments activity of KCNQ4 in HEK cells, mesenteric artery and ...
... in which the mesenteric base twists around the superior mesenteric artery, compromising intestinal perfusion, leading to bowel ...
The superior mesenteric artery and the inferior mesenteric artery (the two main mesenteric arteries), and the superior ... the midgut is supplied by the superior mesenteric artery (SMA), and the hindgut is supplied by the inferior mesenteric artery ( ... Thrombosis of the superior mesenteric vein can cause mesenteric ischemia also known as ischemic bowel. Mesenteric ischemia can ... mesenteric vein and the inferior mesenteric vein (the two main mesenteric veins), plus their branches and the capillaries ...
... inferior frontal gyrus inferior gluteal artery inferior horn inferior meatus inferior mesenteric artery inferior mesenteric ... artery left common carotid artery left gastroepiploic artery left mainstem bronchi left marginal artery left pulmonary artery ... artery superior jugular bulb superior laryngeal artery superior laryngeal nerve superior meatus superior mesenteric artery ... atrium right colic artery right common carotid artery right gastroepiploic artery right mainstem bronchi right marginal artery ...
... the myenteric plexus which itself is derived from the plexuses of parasympathetic nerves around the superior mesenteric artery ...
Similarly, the superior mesenteric artery and inferior mesenteric artery feed structures arising from the embryonic midgut and ... the others are the superior and inferior mesenteric arteries). The celiac artery is the first major branch of the descending ... The celiac artery may also give rise to the inferior phrenic arteries.[citation needed] The celiac artery supplies oxygenated ... This may present no symptoms, but can cause pain due to restricted blood flow to the superior mesenteric artery. Animated ...
... the superior mesenteric artery and the inferior mesenteric artery. The term derives from Ancient Greek: σπλαγχνικός, romanized ...
Retrograde flow to the aneurysm sac from branches such as the lumbar and inferior mesenteric arteries. Type II endoleaks are ... the left common carotid artery and/or the left subclavian artery from the innominate artery or the right common carotid artery ... the calibre/tortuosity of the iliac arteries and the relationship of the neck of the aneurysm to the renal arteries are ... prohibitively small femoral arteries, or circumferential calcification of the femoral or iliac arteries.[citation needed] In ...
Mesenteric artery dissection may limit the blood supply to the intestines. Renal artery dissections can decrease blood flow to ... Arterial diseases can affect one or multiple layers of the artery wall. The aorta is the largest artery in the body, and the ... Coronary artery disease involves the arteries supplying blood to heart muscle. Coronary ischemia results in myocardial ... Uterine artery embolization (UAE) or uterine fibroid embolization (UFE) Prostate artery embolization (PAE) Pulmonary ...
... hemorrhage from erosions into splenic artery and vein, thrombosis of the splenic vein, superior mesenteric vein and portal ... Renal Renal artery or vein thrombosis Kidney failure Circulatory Arrhythmias Hypovolemia and shock myocardial infarction ...
Inferior mesenteric artery Superior mesenteric plexus This article incorporates text in the public domain from page 987 of the ... The inferior mesenteric plexus is derived chiefly from the aortic plexus. It surrounds the inferior mesenteric artery, and ... divides into a number of secondary plexuses, which are distributed to all the parts supplied by the artery, viz., the left ...
Mesenteric artery ischemia occurs when there is a narrowing or blockage of one or more of the three major arteries that supply ... mesenteric; Dead gut - mesenteric; Atherosclerosis - mesenteric artery; Hardening of the arteries - mesenteric artery ... Mesenteric artery ischemia occurs when there is a narrowing or blockage of one or more of the three major arteries that supply ... A mesenteric angiogram is a test that involves injecting a special dye into your bloodstream to highlight the arteries of the ...
... and modulation of sympathetic nerve and norepinephrine-induced constrictor responses in the superior mesenteric artery of the ... and modulation of sympathetic nerve and norepinephrine-induced constrictor responses in the superior mesenteric artery of the ... and modulation of sympathetic nerve and norepinephrine-induced constrictor responses in the superior mesenteric artery of the ... and modulation of sympathetic nerve and norepinephrine-induced constrictor responses in the superior mesenteric artery of the ...
T1 - Significance of perivascular soft tissue around the common hepatic and proximal superior mesenteric arteries arising after ... Significance of perivascular soft tissue around the common hepatic and proximal superior mesenteric arteries arising after ... Significance of perivascular soft tissue around the common hepatic and proximal superior mesenteric arteries arising after ... Significance of perivascular soft tissue around the common hepatic and proximal superior mesenteric arteries arising after ...
Synonyms for Mesenteric artery:. n.. •body (noun). Arteria Mesenterica.. •mesenteric artery (noun). Arteria Mesenterica.. ...
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Superior mesenteric artery (SMA) syndrome is a rare acquired disorder in which acute angulation of SMA causes compression of ... Shukla RC, Pathak R. Superior mesenteric artery syndrome: case report. Nepal Medical College Journal. 2008 Jun; 10(2): 144-5. ... the patient later was admitted in the hospital for refractory gastroparesis associated with superior mesenteric artery syndrome ...
These data demonstrate that direct luminal stimulation of P2Y receptor on the endothelium of rat mesenteric arteries leads to ... which we showed occurs independently of a change in endothelial cell Ca2+ in rat mesenteric arteries. Here we have investigated ... Dilatation then spread rapidly into the adjacent feed artery and upstream against the direction of luminal flow, sufficient to ... In contrast, focal abluminal application of either ATP or UTP at the downstream end of cannulated arteries evoked constriction ...
Superior Mesenteric Artery Syndrome, Wilkie Syndrome, Compression, smas shop, smas adult, smas pediatric, financial assistance ... 2021 by Superior Mesenteric Artery Syndrome Research, Awareness, and Support. Privacy Policy ...
Posts about superior mesenteric artery syndrome written by Docpark ... Category: superior mesenteric artery syndrome. Categories MALS May Thurners Syndrome median arcuate ligament syndrome ... along with other structures such as the duodenum and left renal vein in superior mesenteric artery syndrome and nutcracker ... Common Hepatic Artery Aneurysm, 2.4cm with celiac axis ectasia to 14mm, median arcuate ligament compression of celiac axis. The ...
... ... The involvement of protein kinase C (PKC) in isometric tension development of rat mesenteric arteries was investigated. Non- ... The results of the study suggest that PKC-epsilon can modulate phenylephrine-induced contraction in mesenteric arteries via ... Potassium chloride-induced responses were not altered in transfected arteries. In a separate group of vessels, the relationship ...
Effect of heating on vascular reactivity in rat mesenteric arteries. Michael Massett, S. J. Lewis, J. N. Bales, G. Aldape, K. C ... Effect of heating on vascular reactivity in rat mesenteric arteries. / Massett, Michael; Lewis, S. J.; Bales, J. N. et al. ... Dive into the research topics of Effect of heating on vascular reactivity in rat mesenteric arteries. Together they form a ... title = "Effect of heating on vascular reactivity in rat mesenteric arteries",. author = "Michael Massett and Lewis, {S. J.} ...
We report the first case of locally advanced rectal cancer in which the IMA arose from the superior mesenteric artery (SMA) in ... The root of the IMA was ligated, and Japanese D3 lymphadenectomy was performed, preserving the accessory middle colic artery. ... Few cases have been reported of colorectal cancer with inferior mesenteric artery (IMA) branching abnormalities; therefore, the ... IMA inferior mesenteric artery, SMA superior mesenteric artery, IMV inferior mesenteric vein, FDG fluorodeoxyglucose ...
Report describes imaging features of superior mesenteric artery aneurysm A recent case report published on May 14, 2010 in ... World Journal of Gastroenterology describes the imaging features of a ruptured superior mesenteric artery aneurysm,which ...
By Muhammad Noor, Kyle Cooper, Henry Lujan, et al., Published on 01/01/16
... is a syndrome caused by inadequate blood flow through the mesenteric vessels, resulting in ischemia and eventual gangrene of ... Duplex criteria for native superior mesenteric artery stenosis overestimate stenosis in stented superior mesenteric arteries. J ... Patients with embolization to the superior mesenteric artery (SMA)-that is, acute mesenteric arterial embolism (AMAE)-have an ... Boos S. [Angiography of the mesenteric artery 1976 to 1991. A change in the indications during mesenteric circulatory disorders ...
These findings are consistent with superior mesenteric artery syndrome.. Superior mesenteric artery syndrome (SMA syndrome) is ... Superior mesenteric artery (SMA) syndrome is a rare cause of abdominal pain, nausea and vomiting that may be undiagnosed in ... Superior mesenteric artery syndrome: spectrum of CT findings with multiplanar reconstructions and 3-D imaging. Abdom Imaging. ... Superior mesenteric artery syndrome: diagnosis and treatment from the gastroenterologists view. J Gastroenterol. 2002;37:640-3 ...
Massive intestinal bleeding in a child with superior mesenteric artery aneurysm and gastrointestinal tuberculosis. J Pediatr ... Massive intestinal bleeding in a child with superior mesenteric artery aneurysm and gastrointestinal tuberculosis.. ...
Chronic pancreatitis is commonly defined as a continuing, chronic, inflammatory process of the pancreas, characterized by irreversible morphologic changes. This chronic inflammation can lead to chronic abdominal pain and/or impairment of endocrine and exocrine function of the pancreas.
These data directly demonstrate a critical role for Cx40 in EDHF-mediated dilation of rat mesenteric arteries. ... pressurized mesenteric arteries of the rat. Validation was achieved by luminally loading cell-impermeant fluorescent dyes ... Furthermore, simultaneous intra- and extraluminal incubation of pressurized arteries with inhibitory peptides targeted against ... In resistance arteries, spread of hyperpolarization from the endothelium to the adjacent smooth muscle is suggested to be a ...
... chronic liver disease enhances phenylephrine-induced endothelial nitric oxide release in rat mesenteric resistance arteries ... chronic liver disease enhances phenylephrine-induced endothelial nitric oxide release in rat mesenteric resistance arteries ...
Mesenteric Arteries. Nitric Oxide. Prostaglandins. Rats. Superoxides. Vasodilator Agents. Dietary Supplements. Orchiectomy ... For this purpose mesenteric artery segments obtained from control, orchidectomized or orchidectomized plus DHA-supplemented ... Based on these data and since the mesenteric artery importantly controls the systemic vascular resistance, the objective of ... Docosahexaenoic Acid Supplemented Diet Influences the Orchidectomy-Induced Vascular Dysfunction in Rat Mesenteric Arteries. ...
RATIONALE Superior mesenteric artery (SMA) syndrome, also known as Wilkie syndrome, is a rare benign disease characterized by ... Superior mesenteric artery syndrome after colectomy: A case report and literature review. ... Superior mesenteric artery syndrome after colectomy: A case report and literature review. ...
Aqueous fraction from Hibiscus sabdariffa relaxes mesenteric arteries of normotensive and hypertensive rats.Jun 14, 2020. ...
Additionally, mesenteric arteries were markedly impaired in Cth−/− mice, and removal of the endothelium prevented methacholine- ... Vasodilator activity of hydrogen sulfide (H2S) in human mesenteric arteries. Microvasc. Res. 109, 38-44 (2017). ... Another study, using human mesenteric arteries obtained from patients undergoing abdominal surgery, demonstrated NaHS-mediated ... Decreased levels of bound sulfane sulfur and total sulfide found in patients with coronary artery disease or peripheral artery ...
Enhanced cyclooxygenase-1 expression within the superior mesenteric artery of portal hypertensive rats: role in the ... Enhanced cyclooxygenase-1 expression within the superior mesenteric artery of portal hypertensive rats: role in the ...
... had significant stenoses in both mesenteric arteries. Patients with celiac or superior mesenteric artery stenoses were older (p ... had significant stenoses in both mesenteric arteries. Patients with celiac or superior mesenteric artery stenoses were older (p ... had significant stenoses in both mesenteric arteries. Patients with celiac or superior mesenteric artery stenoses were older (p ... had significant stenoses in both mesenteric arteries. Patients with celiac or superior mesenteric artery stenoses were older (p ...
H. Hepatic artery. M, Col. Branches of superior mesenteric artery. m, m. Branches of inferior mesenteric artery. S. Splenic ... intestinales) also arise from the right instead of the left side of the superior mesenteric artery.. [back]. ... the arteries to the small intestine (aa. ...
Renal And Mesenteric Artery Disease. Reproductive Endocrinology And Infertility (Re And Ivf). Resynchronization And Advanced ... Coronary Artery Disease Program. Corrigan Womens Heart Health Program. Cranial Base Center. Critical Care. Critical Care - ... Stroke And Carotid Artery Disease Program. Stroke Services, Pediatric. Surgery, Pediatric. Survivorship Program. Swallowing And ... Peripheral Artery Disease Program. Peripheral Nerve Surgery. Phototherapy Unit. Physical Medicine & Rehabilitation, Pediatric. ...
  • Mesenteric artery ischemia occurs when there is a narrowing or blockage of one or more of the three major arteries that supply the small and large intestines. (
  • The outlook for chronic mesenteric ischemia is good after a successful surgery. (
  • People with acute mesenteric ischemia often do poorly because parts of the intestine may die before surgery can be done. (
  • However, with prompt diagnosis and treatment, acute mesenteric ischemia can be treated successfully. (
  • Tissue death from lack of blood flow (infarction) in the intestines is the most serious complication of mesenteric artery ischemia. (
  • Various laboratory studies may be performed for suspected acute mesenteric ischemia (AMI), but in general, such studies will not establish the diagnosis. (
  • The remaining allegation was failure to prevent nonocclusive mesenteric ischemia (NOMI). (
  • See also Mesenteric Ischemia Imaging . (
  • Pneumatosis intestinalis (black stripes of air) in advanced acute mesenteric ischemia (AMI) with gangrenous bowel. (
  • Pneumatosis intestinalis, one of few radiographic findings in patients with mesenteric ischemia. (
  • A rich network of collaterals connects the terminal arterioles of each of these arteries, thus making the rectum relatively resistant to ischemia. (
  • Acute mesenteric ischemia resulted from ligation of the celiac artery, with complete thrombosis of the mesenteric vessels. (
  • Mesenteric ischemia is either acute or chronic and is classified etiologically as nonocclusive, venous occlusion, or arterial occlusion. (
  • Various case reports have shown mesenteric ischemia after laparoscopic procedures, in which most patients have a history of atherosclerosis. (
  • [ 5 ] Moreover, the elevation of the intraabdominal pressure in pneumoperitoneum creation during the laparoscopic procedure can cause a decreased arterial perfusion and ischemia of the mesenteric organs, even in the absence of atherosclerosis. (
  • Arteriovenous malformation of the inferior mesenteric artery presentin" by Muhammad Noor, Kyle Cooper et al. (
  • Gastroenterology consultants recommended mesenteric duplex imaging, which revealed a 60-99% stenosis of the inferior mesenteric artery and a patent superior mesenteric artery. (
  • 2. Inferior mesenteric artery branches a. (
  • A recent case report published on May 14, 2010 in World Journal of Gastroenterology describes the imaging features of a ruptured superior mesenteric artery aneurysm,which created a giant hematoma and mimicked a pancreatic mass, with mild dilatation of main pancreatic duct. (
  • Massive intestinal bleeding in a child with superior mesenteric artery aneurysm and gastrointestinal tuberculosis. (
  • Purpose: To evaluate the interval change of perivascular soft tissue (PVST) around the common hepatic and proximal superior mesenteric arteries arising after pancreaticoduodenectomy (PD) and to compare the difference between post operative change (benign PVST) and recurrence (malignant PVST). (
  • At the terminus of the common hepatic artery, where the hepatic bifurcated was a 2.4cm aneurysm with mural thrombus. (
  • Nodes along the superior mesenteric, gastroduodenal, common hepatic, and splenic arteries, as well as the celiac trunk, are the second station of lymph nodes. (
  • Usually the cystic artery arises from the right hepatic artery, passing behind the common hepatic and cystic duct in the Calot triangle, to reach the upper surface of the neck of the gall bladder, where it divides into superficial and deep branches [6,7]. (
  • The arteries that supply blood to the intestines run directly from the aorta. (
  • The aorta is the main artery from the heart. (
  • The blockage is removed and the arteries are reconnected to the aorta. (
  • Superior mesenteric artery (SMA) syndrome is a rare acquired disorder in which acute angulation of SMA causes compression of the third part of the duodenum between the SMA and the aorta, leading to obstruction. (
  • compression of the duodenum between the abdominal aorta and superior mesenteric artery resulting in intestinal obstruction, dilation of the left renal vein, and gastric distension. (
  • Patients diagnosed with SMA syndrome have a characteristically short distance between the superior mesenteric artery and the aorta (usually 2-8 mm) in contrast to healthy patients (10-34 mm). (
  • Superior mesenteric artery syndrome (SMA syndrome) is the result of compression of the third portion of the duodenum between the superior mesenteric artery and the abdominal aorta. (
  • compression of the duodenum between the abdominal aorta and superior mesenteric artery (Figure), dilation of theleft renal vein, and distension of the stomach. (
  • Computed tomography of the abdomen and pelvis demonstrating compression of the duodenum between the abdominal aorta and superior mesenteric artery (A), dilation of the left renal vein (B), distension of the stomach (C), and the aortomesenteric angle (D). (
  • RATIONALE Superior mesenteric artery (SMA) syndrome , also known as Wilkie syndrome , is a rare benign disease characterized by small bowel obstruction due to compression of the third portion of the duodenum by the SMA and the abdominal aorta . (
  • Arteries which arise from the abdominal aorta and distribute to most of the intestines. (
  • His prior visits to the emergency room had revealed a hepatic artery aneurysm and celiac axis aneurysm. (
  • Downstream in the splenic and hepatic artery and its branches, turbulent flow can engender tortuosity (lengthening) and aneurysms (widening). (
  • Processes involving the gallbladder and nearby hepatic artery refer to the right upper quadrant abdomen, right chest, right shoulder and scapula which was where the patient's pain was. (
  • While performing pancreaticoduodenectomy, early neck division may be impossible or inadequate in case of hepatic artery anatomic variants, suspected involvement of the superior mesenteric vessels, intraductal papillary mucinous neoplasm, and pancreatic head bleeding pseudoaneurysm. (
  • Thirty-two had hepatic artery anatomic variant and 2 had bleeding pancreatic head pseudoaneurysm. (
  • The hepatic artery variant was preserved in all cases out of 2 in which arterial reconstruction was performed. (
  • Occasionally the cystic artery arises from the hepatic artery and sometimes from the gastroduodenal artery. (
  • accessory pancreatic or splenic arteries.Objective: To present three cases of accessory right hepatic artery originating from the superior mesenteric artery in black African cadavers as found during routine cadaveric dissections.Materials and Method: The abdomens of 8 adult male black African cadavers were dissected according to the description and guidance by Romanes (1996). (
  • The inferior mesenteric vein ascends in the retroperitoneal plane over the psoas muscle and continues posterior to the pancreas to join the splenic vein. (
  • People with hardening of the arteries that supply the intestines often have the same problems in blood vessels that supply the heart, brain, kidneys, or legs. (
  • 11. Colorectal and Anorectal Lymphatic Drainage The lymphatic drainage of the colon originates in a network of lymphatics in the muscularis mucosa.Lymphatic vessels and lymph nodes followthe regional arteries. (
  • Notable amongst these is an early right posterior approach to the superior mesenteric vessels, with mesopancreas (MP) dissection close to the origin of the SMA. (
  • Elucidation of the temporal relationship between endothelial-derived NO and EDHF in mesenteric vessels. (
  • Anatomical study of the cystic artery is important because its origin from the nearby vessels and because its relation to the biliary ducts is very variable, creating potential difficulties during surgery [1-5]. (
  • Based on these data and since the mesenteric artery importantly controls the systemic vascular resistance, the objective of this study was to analyze the effect of a DHA-supplemented diet on the mesenteric vascular function from orchidectomized rats. (
  • Enhanced cyclooxygenase-1 expression within the superior mesenteric artery of portal hypertensive rats: role in the hyperdynamic circulation. (
  • OBJECTIVE: Investigate the storage, release, and activity of ET-1 system in arteries from young and aged Fischer-344 rats. (
  • Our previous studies showed that the magnesium Mg2+-induced relaxations were completely dependent on concentration of nitric oxide (NO) in non-diabetic rat mesenteric vascular beds, in diabetic rats other mechanisms may be involved. (
  • We first corroborated our earlier work by showing that pro- and active forms of MMP-2 were increased in small renal arteries from pregnant compared with virgin rats and Rlx-treated compared with vehicle-treated nonpregnant rats. (
  • MMP-2 mRNA as measured by real-time PCR was increased in small renal arteries from pregnant and Rlx-treated nonpregnant rats compared with their respective controls. (
  • Thus increases in MMP-2 mRNA and protein expression are major factors contributing to increased MMP-2 activity in small arteries from pregnant and Rlx-treated nonpregnant rats. (
  • Fifty-six patients (27%) had a 50% or greater stenosis in the celiac or superior mesenteric artery, and seven patients (3.4%) had significant stenoses in both mesenteric arteries. (
  • Patients with celiac or superior mesenteric artery stenoses were older (p = 0.002) and had a higher prevalence of hypertension (p = 0.029) than those without significant mesenteric stenoses. (
  • In the present study asymptomatic celiac or superior mesenteric artery stenoses were common among male veterans evaluated for peripheral vascular disease, but the prevalence of significant stenoses in both the celiac and superior mesenteric arteries was low. (
  • The distinction of a T3 from a T4 tumor is important given that tumors extending to the celiac or superior mesenteric arteries (T4) are generally not surgically resectable for cure. (
  • Here we have investigated the potential of P2Y receptor stimulation to evoke spreading dilatation in rat resistance small arteries under physiological pressure and flow. (
  • To corroborate these results obtained by gelatin zymography, pro-MMP-2 protein was determined by Western analysis in the same small arteries. (
  • In studies where the endothelium is stimulated acutely, EDHF responses predominate in small arteries. (
  • Of santorini, are supplied by the inferior mesenteric vein from one out the caudate lobe, 288-28g. (
  • 9. Venous drainage Except for the inferior mesenteric vein, the veins of the colon, rectum, and anus parallel their corresponding arteries and bear the same terminology. (
  • mesenteric arteries (MA) and veins (MV) were mounted on glass cannulas, intravascularly filled with fluorescent dextran and incrementally pressurized above their in vivo physiological values. (
  • portal veins and gastroduodenal arteries were exposed.Results: Three cadaveric cases of the accessory right hepatic arteries arising from the superior mesenteric arteries were observed. (
  • Non-invasive vascular studies intend to evaluate the health of arteries and veins by utilizing advanced technologies like imaging, ultrasound and several other techniques. (
  • [5] There is an increase in the pulmonary artery pressure, hypervolemia, polycythemia, and increased blood viscosity, all lead to additional stress on heart, predisposing personnel to Acute Coronary Syndrome (ACS). (
  • Rapid endothelial cell-selective loading of connexin 40 antibody blocks endothelium-derived hyperpolarizing factor dilation in rat small mesenteric arteries. (
  • In resistance arteries, spread of hyperpolarization from the endothelium to the adjacent smooth muscle is suggested to be a crucial component of dilation resulting from endothelium-derived hyperpolarizing factor (EDHF). (
  • To probe the role of endothelial gap junctions in EDHF-mediated dilation, we developed a method, which was originally used to load membrane impermeant molecules into cells in culture, to load connexin (Cx)-specific inhibitory molecules rapidly (approximately 15 minutes) into endothelial cells within isolated, pressurized mesenteric arteries of the rat. (
  • These data directly demonstrate a critical role for Cx40 in EDHF-mediated dilation of rat mesenteric arteries. (
  • Homozygous mutation of this gene results in impaired flow-induced dilation in mesenteric resistance arteries. (
  • Spreading dilatation to luminal perfusion of ATP and UTP in rat isolated small mesenteric arteries. (
  • Regadenoson, dipyridamole and adenosine are commonly used vasodilators in myocardial perfusion imaging for the detection of obstructive coronary artery disease. (
  • Ileocolic artery (absent in up to 20 percent of people) supplies blood flow to the terminal ileum and proximal ascending colon. (
  • Superior rectal artery supplies the proximal rectum. (
  • Single oral doses of labetalol hydrochloride administered to patients with coronary artery disease had no significant effect on sinus rate, intraventricular conduction, or QRS duration. (
  • The results of the study suggest that PKC-epsilon can modulate phenylephrine-induced contraction in mesenteric arteries via calcium-independent pathways. (
  • A computed tomography (CT) of the abdomen and pelvis was ordered to further evaluate the etiology of the patient's symptoms revealing a severely distended stomach and distal duodenum with obstruction at the level of the superior mesenteric artery. (
  • The donor pancreas is retrieved en bloc with the duodenum, which is transected and stapled proximally just beyond the pylorus and distally in the third part of the duodenum. (
  • Potential areas for injury can be the duodenum and superior mesenteric artery for the right colon and the ureters for both sides. (
  • Tumors extending to the celiac artery or superior mesenteric artery are considered T4 lesions, whereas tumors involving any of the surrounding structures of the pancreas, such as the portal vein, duodenum, or ampulla of Vater, without involvement of the celiac artery or superior mesenteric artery are classified as T3 tumors. (
  • EDHF signals radially from the endothelium to cause dilatation, and appears mechanistically distinct from the axial spread of dilatation, which we showed occurs independently of a change in endothelial cell Ca2+ in rat mesenteric arteries. (
  • Triple cannulation of isolated arteries enables focal application of purine and pyrimidine nucleotides to the endothelium, avoiding potential complicating actions of these agents on the smooth muscle. (
  • These data demonstrate that direct luminal stimulation of P2Y receptor on the endothelium of rat mesenteric arteries leads to marked spreading dilatation and thus suggests that circulating purines and pyrimidines may act as important regulators of blood flow. (
  • Thrombin did not cause endothelium-dependent contraction of young arteries. (
  • In aged but not young arteries, thrombin rapidly increased ET-1 release, which was abolished by endothelium denudation or TAT-NSF. (
  • The prevalence of unsuspected renal artery stenosis among patients with peripheral vascular disease has been reported to be as high as 40%, but the prevalence of asymptomatic celiac and superior mesenteric artery stenoses in these patients is not known. (
  • Regadenoson is a more potent vasodilator than adenosine and exhibits selectivity for the coronary circulation relative to the renal, peripheral and mesenteric circulation in animals [ 5 ]. (
  • ABSTRACT The anatomy of the cystic artery is very variable, creating potential problems during surgery. (
  • Occlusive arterial and venous thromboemboli can cause ischemic colitis (IC), but hypoperfusion without occlusion of the mesenteric or the internal iliac arteries is the main mechanism. (
  • The purpose of the present study as to evaluate the effect of changes in intravascular pressure and the inflammatory mediator bradykinin on rat mesenteric arterial and venous vascular permeability. (
  • There were no significant differences in tissue inhibitor of metalloproteinase (TIMP-1 or TIMP-2) activity by reverse zymography in small renal arteries. (
  • Superior mesenteric artery branches a. (
  • The terminal branches of each artery form anastomoses with the terminal branches of the adjacent artery and communicate via the marginal artery of Drummond (complete in only 15-20 percent of people). (
  • 3. Internal iliac artery branches a. (
  • In contrast, focal abluminal application of either ATP or UTP at the downstream end of cannulated arteries evoked constriction, which only in the case of ATP was also associated with modest spread of dilatation. (
  • Increased endothelial exocytosis and generation of endothelin-1 contributes to constriction of aged arteries. (
  • IMSEAR at SEARO: Superior mesenteric artery syndrome: case report. (
  • Shukla RC, Pathak R. Superior mesenteric artery syndrome: case report. (
  • Unfortunately the patient later was admitted in the hospital for refractory gastroparesis associated with superior mesenteric artery syndrome. (
  • These findings are consistent with superior mesenteric artery syndrome. (
  • Superior mesenteric artery syndrome after colectomy: A case report and literature review. (
  • Oxygen dysregulation in the placenta, abnormal remodeling of the spiral artery, defective placentation, oxidative stress at the fetal-maternal border, inflammation and angiogenic impairment in the maternal circulation are the main causes of this syndrome. (
  • Standard PD is usually performed with transection of the pancreatic neck before the superior mesenteric artery (SMA) dissection [ 8 - 10 ]. (
  • We have adopted this hind right approach to the SMA since 2007 and have been using it combined with the early isolation and dissection free of the superior mesenteric vein (SMV) beneath the pancreas, as our "standard approach" PD in selected indications such as HA anatomic variants, suspected involvement of mesentericoportal axis or SMA, MD-IPMN, and pancreatic head bleeding pseudoaneurysm. (
  • High ligation of the arteries and the maintenance of the dissection up to the pancreatic level are the critical points of the procedure. (
  • While doing the normal dissection of the left upper limb on the 35 year old female cadaver, medical students saw a strangely and superficially placed ulnar artery that arose from the brachial artery way up within the upper part of the middle 3rd of the arm. (
  • Anticoagulation and thrombolytic therapy were also given for treatment of a left popliteal artery thrombosis. (
  • Soma 350 Mg Pill etc. 305 the inferior iliac artery, except that muscle, as noticod abo\'e, r. (
  • BigET-1 levels and contraction to exogenous BigET-1 (but not ET-1) were also increased in aged compared to young arteries. (
  • This can show the location of the blockage in the artery. (
  • A stent may be used as an alternative to surgery to enlarge the blockage in the artery or to deliver medicine directly to the affected area. (
  • Findings were similar for mesenteric arteries. (
  • Vasopressin should not be used in patients with vascular disease, especially disease of the coronary arteries, except with extreme caution. (
  • This superficial ulnar artery coursed within the deep brachial and ante-brachial fascia, making it superficial to all flexor muscles of the flexor compartment of the forearm. (
  • Glucagon pharmacodynamics and modulation of sympathetic nerve and norepinephrine-induced constrictor responses in the superior mesenteric artery of the cat. (
  • The non-hydrolysable ADP analogue, ADPbetaS, acting at P2Y1 receptors, caused robust local and spreading dilatation responses whether applied to the luminal or abluminal surface of pressurized arteries. (
  • Potassium chloride-induced responses were not altered in transfected arteries. (
  • Based on these studies, it has been proposed that the hepoxilins and trioxilins function in human physiology and pathology by, for example, promoting inflammation responses and dilating arteries to regulate regional blood flow and blood pressure. (
  • EDHF responses in these mouse arteries were inhibited by an intracellular calcium blocker, TMB-8, and the phospholipase A(2) inhibitor AACOCF(3), suggesting a role for lipid metabolites. (
  • Colombani P "Upper extremity gangrene secondary to superior mesenteric artery infusion of vasopressin. (
  • This study documents variations in the origin of the cystic artery and its location in relation to the biliary ducts among 106 Sudanese people and compared the variations between the sexes and races. (
  • Statistically significant variations in the origin and position of the cystic artery were found comparing these data with previous studies in Caucasians and Asians. (
  • The cystic artery might be doubled, and variations in the position and drainage of the artery have been noted [3-5]. (
  • The incidence of variations in the origin of the cystic artery has been documented in Caucasians, e.g. in studies by Anson [1] and Daseler et al. (
  • 2]. However, the anatomy of the cystic artery in Africans is not well documented. (
  • The aim of this study was to record the variations in origin of the cystic artery from different sources and its location in relation to the biliary ducts among Sudanese people and to compare the variations between the sexes and different races. (