TRPM Cation Channels
Thermoreceptors
Marketing
Monoterpenes
Acrolein
Tobacco Industry
Thymol
Transient Receptor Potential Channels
Irritants
The posterior nasal nerve plays an important role on cardiopulmonary reflexes to nasal application of capsaicin, distilled water and l-menthol in anesthetized dogs. (1/240)
The sensory innervation of the cardiopulmonary reflexes to nasal application of capsaicin (CAPS), distilled water (DW) and l-menthol (LM) was studied in anesthetized dogs breathing through tracheostomy. A marked cardiopulmonary reflex was observed by CAPS and DW into the nasal cavity, while a prolongation of expiration was induced by LM. All these reflexes were significantly decreased by bilateral section of the posterior nasal nerve (PNN) and completely abolished by topical nasal anesthesia with lidocaine. Responses of the whole nerve activity of the PNN to these substances corresponded to the magnitude of the reflexes. These results indicate that PNN afferents play an important role on the reflex elicitation of the noxious, water and cold stimuli from the nasal cavity. (+info)Metabolism of (R)-(+)-pulegone and (R)-(+)-menthofuran by human liver cytochrome P-450s: evidence for formation of a furan epoxide. (2/240)
(R)-(+)-Pulegone, a monoterpene constituent of pennyroyal oil, is a hepatotoxin that has been used in folklore medicine as an abortifacient despite its potential lethal effects. Pulegone is metabolized by human liver cytochrome P-450s to menthofuran, a proximate hepatotoxic metabolite of pulegone. Expressed human liver cytochrome (CYP) P-450s (1A2, 2A6, 2C9, 2C19, 2D6, 2E1, and 3A4) were tested for their ability to catalyze the oxidations of pulegone and menthofuran. Expressed CYP2E1, CYP1A2, and CYP2C19 oxidized pulegone to menthofuran, with respective Km and Vmax values of 29 microM and 8.4 nmol/min/nmol P-450 for CYP2E1, 94 microM and 2.4 nmol/min/nmol P-450 for CYP1A2, and 31 microM and 1.5 nmol/min/nmol P-450 for CYP2C19. The human liver P-450s involved in the metabolism of menthofuran are the same as pulegone except for the addition of CYP2A6. These P-450s were found to oxidize menthofuran to a newly identified metabolite, 2-hydroxymenthofuran, which is an intermediate in the formation of the known metabolites mintlactone and isomintlactone. Based on studies with 18O2 and H218O, 2-hydroxymenthofuran arises predominantly from a dihydrodiol formed from a furan epoxide. CYP2E1, CYP1A2, and CYP2C19 oxidized menthofuran with respective Km and Vmax values of 33 microM and 0.43 nmol/min/nmol P-450 for CYP2E1, 57 microM and 0.29 nmol/min/nmol P-450 for CYP1A2, and 62 microM and 0.26 nmol/min/nmol P-450 for CYP2C19. (+info)Developmental regulation of monoterpene biosynthesis in the glandular trichomes of peppermint. (3/240)
Monoterpene production in peppermint (Mentha x piperita L.) glandular trichomes is determined by the rate of biosynthesis, as determined by (14)CO(2) incorporation, and is restricted to leaves 12 to 20 d of age. Using oil glands isolated from peppermint leaves of different ages, in vitro assay of the eight sequential enzymes responsible for the biosynthesis of the principal monoterpene (-)-menthol indicated that all but one biosynthetic enzyme had a very similar developmental profile. Activities were highest in leaves 12 to 20 d of age, with a sharp peak centered at 15 d. The exception, (-)-menthone reductase, the last enzyme of the pathway, exhibited a later peak of activity, which was centered at approximately 21 d. The correlation between in vitro enzyme activity and the rate of biosynthesis measured in vivo suggests that monoterpene formation is controlled mainly by the coordinately regulated activity of the relevant biosynthetic enzymes. Developmental immunoblotting of limonene synthase, which catalyzes the committed step of the pathway, demonstrated a direct correlation between enzyme activity and enzyme protein, suggesting that the dynamic time course for the remaining pathway enzyme activities also reflects the corresponding protein levels. RNA-blot analyses indicated that the genes encoding enzymes of the early pathway steps are transcriptionally activated in a coordinated fashion, with a time course superimpossible with activity measurements and immunoblot data. These results demonstrating coincidental temporal changes in enzyme activities, enzyme protein level, and steady-state transcript abundances indicate that most of the monoterpene biosynthetic enzymes in peppermint are developmentally regulated at the level of gene expression. (+info)Amplification of odor-induced Ca(2+) transients by store-operated Ca(2+) release and its role in olfactory signal transduction. (4/240)
A critical role of Ca(2+) in vertebrate olfactory receptor neurons (ORNs) is to couple odor-induced excitation to intracellular feedback pathways that are responsible for the regulation of the sensitivity of the sense of smell, but the role of intracellular Ca(2+) stores in this process remains unclear. Using confocal Ca(2+) imaging and perforated patch recording, we show that salamander ORNs contain a releasable pool of Ca(2+) that can be discharged at rest by the SERCA inhibitor thapsigargin and the ryanodine receptor agonist caffeine. The Ca(2+) stores are spatially restricted; emptying produces compartmentalized Ca(2+) release and capacitative-like Ca(2+) entry in the dendrite and soma but not in the cilia, the site of odor transduction. We deplete the stores to show that odor stimulation causes store-dependent Ca(2+) mobilization. This odor-induced Ca(2+) release does not seem to be necessary for generation of an immediate electrophysiological response, nor does it contribute significantly to the Ca(2+) transients in the olfactory cilia. Rather, it is important for amplifying the magnitude and duration of Ca(2+) transients in the dendrite and soma and is thus necessary for the spread of an odor-induced Ca(2+) wave from the cilia to the soma. We show that this amplification process depends on Ca(2+)-induced Ca(2+) release. The results indicate that stimulation of ORNs with odorants can produce Ca(2+) mobilization from intracellular stores without an immediate effect on the receptor potential. Odor-induced, store-dependent Ca(2+) mobilization may be part of a feedback pathway by which information is transferred from the distal dendrite of an ORN to its soma. (+info)'Microsmatic' primates revisited: olfactory sensitivity in the squirrel monkey. (5/240)
Using a conditioning paradigm, the olfactory sensitivity of three squirrel monkeys to nine odorants representing different chemical classes as well as members of a homologous series of substances was investigated. The animals significantly discriminated dilutions as low as 1:10,000 n-propionic acid, 1:30,000 n-butanoic acid and n-pentanoic acid, 1:100,000 n-hexanoic acid, 1:1Mio n-heptanoic acid, 1:30, 000 1-pentanol, 1:300,000 1,8-cineole, 1:1Mio n-heptanal and 1:30Mio amyl acetate from the near-odorless solvent, with single individuals scoring even slightly better. The results showed (i) the squirrel monkey to have an unexpectedly high olfactory sensitivity, which for some substances matches or even is better than that of species such as the rat or the dog, and (ii) a significant negative correlation between perceptibility in terms of olfactory detection thresholds and carbon chain length of carboxylic acids. These findings support the assumptions that olfaction may play a significant and hitherto underestimated role in the regulation of primate behavior, and that the concept of primates as primarily visual and 'microsmatic' animals needs to be revised. (+info)Purification and characterization of a Baeyer-Villiger mono-oxygenase from Rhodococcus erythropolis DCL14 involved in three different monocyclic monoterpene degradation pathways. (6/240)
A Baeyer-Villiger mono-oxygenase (BVMO), catalysing the NADPH- and oxygen-dependent oxidation of the monocyclic monoterpene ketones 1-hydroxy-2-oxolimonene, dihydrocarvone and menthone, was purified to homogeneity from Rhodococcus erythropolis DCL14. Monocyclic monoterpene ketone mono-oxygenase (MMKMO) is a monomeric enzyme of molecular mass 60 kDa. It contains 1 mol of FAD/monomer as the prosthetic group. The N-terminal amino acid sequence showed homology with many other NADPH-dependent and FAD-containing (Type 1) BVMOs. Maximal enzyme activity was measured at pH 9 and 35 degrees C. MMKMO has a broad substrate specificity, catalysing the lactonization of a large number of monocyclic monoterpene ketones and substituted cyclohexanones. The natural substrates 1-hydroxy-2-oxolimonene, dihydrocarvone and menthone were converted stoichiometrically into 3-isopropenyl-6-oxoheptanoate (the spontaneous rearrangement product of the lactone formed by MMKMO), 4-isopropenyl-7-methyl-2-oxo-oxepanone and 7-isopropyl-4-methyl-2-oxo-oxepanone respectively. The MMKMO-catalysed conversion of iso-dihydrocarvone showed an opposite regioselectivity to that of dihydrocarvone; in this case, 6-isopropenyl-3-methyl-2-oxo-oxepanone was formed as the product. MMKMO converted all enantiomers of the natural substrates with almost equal efficiency. MMKMO is involved in the conversion of the monocyclic monoterpene ketone intermediates formed in the degradation pathways of all stereoisomers of three different monocyclic monoterpenes, i.e. limonene, (dihydro)carveol and menthol. (+info)Role of C-5 chiral center in R-(+)-pulegone-mediated hepatotoxicity: metabolic disposition and toxicity of 5, 5-dimethyl-2-(1-Methylethylidene)-cyclohexanone in rats. (7/240)
Metabolic disposition of 5, 5-dimethyl-2-(1-methylethylidene)-cyclohexanone (I) was examined in rats. Compound (I) was administered orally (250 mg/kg of body weight/day) to rats for 5 days. The following urinary metabolites were isolated and identified: 4,5,6,7-tetrahydro-3,6, 6-trimethylbenzofuran (III), 3,3-dimethylcyclohexanone (VI), 5, 5-dimethyl-3-hydroxy-2-(1-methylethylidene)-cyclohexanone (X), 5, 5-dimethyl-2-(1-hydroxymethylethyl)-cyclohexanone (IX), 3-hydroxy-5-hydroxymethyl-5-methyl-2-(1-methylethylidene)-cyclo hexano ne (XI), 5,6-dihydro-3,6,6-trimethyl-2(4H)-benzofuranone (VIII), and 5,5-dimethyl-3-hydroxy-2-(1-carboxy ethylidene)-cyclohexanone (XIII). Incubation of compound (I) with phenobarbital (PB)-induced rat liver microsomes in the presence of NADPH resulted in the formation of a metabolite, tentatively identified as a furanoterpene (III) based on proton magnetic resonance, gas chromatography, and gas chromatography-mass spectroscopy analyses. The formation of III was inhibited to a significant extent by carbon monoxide, metyrapone, SKF 525-A, and cytochrome c, suggesting the participation of PB-induced microsomal cytochrome P-450 system in the conversion of I to III. Compound I gave type I spectral change in the PB-induced liver microsomes and the dissociation constant (Ks) for I was 38.5 microM. Intraperitoneal administration of a single dose (250 mg/kg) of I to rats resulted in 26, 23, and 41% decreases in the levels of cytochrome P-450, glucose-6-phosphatase, and aminopyrine N-demethylase, respectively, at the end of 24 h. During this period, a 11-fold increase in serum glutamate pyruvate transaminase level was also observed. However, a decrease in the level of cytochrome P-450 and glucose-6-phosphatase, and an increase in serum glutamate pyruvate transaminase values were comparatively more pronounced when R-(+)-pulegone (250 mg/kg) or CCl(4) (0.6 ml/kg) was administered to rats. Pretreatment of rats with PB potentiated the hepatotoxicity caused by I, whereas pretreatment with 3-methylcholanthrene protected from it. This suggests that PB-induced cytochrome P-450-catalyzed reactive metabolites may be responsible for the toxic effects caused by I. (+info)Inhibition of plant asparagine synthetase by monoterpene cineoles. (8/240)
Asparagine (Asn) synthetase (AS) is the key enzyme in Asn biosynthesis and plays an important role in nitrogen mobilization. Despite its important physiological function, little research has been done documenting inhibitors of plant AS. Plant growth inhibition caused by the natural monoterpene 1,4-cineole and its structurally related herbicide cinmethylin was reversed 65% and 55%, respectively, by providing 100 microM Asn exogenously. Reversion of the phytotoxic effect was dependent on the concentration of Asn. The presence of either 1,4-cineole or cinmethylin stimulated root uptake of [(14)C]Asn by lettuce (Lactuca sativa) seedlings. Although the physiological responses suggested that both compounds affected Asn biosynthesis, biochemical analysis of AS activity showed that the natural monoterpene was a potent inhibitor (I(50) = approximately 0. 5 microM) of the enzyme, whereas the commercial product was not inhibitory up to levels of 10 mM. Analysis of the putative metabolite, 2-hydroxy-1,4-cineole, showed that the cis-enantiomer was much more active than the trans-enantiomer, suggesting that the hydroxyl group was involved in the specific ligand/active site interaction. This is the first report that AS is a suitable herbicide target site, and that cinmethylin is apparently a proherbicide that requires metabolic bioactivation via cleavage of the benzyl-ether side chain. (+info)Menthol is a naturally occurring compound that is commonly found in mint plants. It is often used in over-the-counter medications and personal care products, such as cough drops, toothpaste, and mouthwashes, due to its ability to provide a cooling sensation on the skin and in the mouth. In the medical field, menthol is used for its analgesic (pain-relieving) and anti-inflammatory properties. It is sometimes used topically to relieve pain and itching associated with conditions such as insect bites, sunburn, and eczema. Menthol is also used in some medications to treat respiratory conditions, such as coughs and colds, by acting as a decongestant and expectorant. However, it is important to note that menthol can cause irritation and allergic reactions in some people, and it should be used with caution, especially in individuals with sensitive skin or respiratory conditions. Additionally, some studies have suggested that menthol may have negative effects on lung function in individuals with asthma or chronic obstructive pulmonary disease (COPD), so it is important to consult with a healthcare provider before using menthol-containing products.
Antipruritics are medications that are used to relieve itching or pruritus. Pruritus is a common symptom of many medical conditions, including skin disorders, liver disease, kidney disease, and neurological disorders. Antipruritics work by blocking the transmission of itch signals from the skin to the brain, or by reducing the production of substances that cause itching. Examples of antipruritics include antihistamines, corticosteroids, and opioid antagonists. These medications are often used to treat conditions such as eczema, psoriasis, and hives, as well as to relieve the itching associated with certain types of cancer treatments.
TRPM (transient receptor potential melastatin) cation channels are a family of non-selective cation channels that are activated by a variety of stimuli, including temperature, mechanical stress, and chemical compounds. These channels are expressed in a wide range of cell types, including neurons, smooth muscle cells, and immune cells. TRPM channels play important roles in a variety of physiological processes, including sensory perception, regulation of body temperature, and control of cell volume. For example, TRPM8 channels are activated by cold temperatures and are involved in the sensation of cold. TRPV1 channels are activated by heat and are involved in the sensation of pain. TRPM2 channels are involved in the regulation of body temperature and the response to oxidative stress. In the medical field, TRPM channels have been implicated in a number of diseases and conditions, including pain, inflammation, and neurodegenerative disorders. For example, TRPV1 channels have been shown to play a role in the development of inflammatory pain, and TRPM2 channels have been implicated in the pathogenesis of Alzheimer's disease. In addition, TRPM channels are being studied as potential targets for the development of new therapeutic agents for a variety of conditions.
In the medical field, "cold temperature" refers to a body temperature that is below the normal range of 98.6°F (37°C). This can be caused by a variety of factors, including exposure to cold temperatures, certain medical conditions, or the use of certain medications. A person with a cold temperature may experience symptoms such as shivering, feeling weak or fatigued, and having difficulty concentrating. In severe cases, a cold temperature can lead to hypothermia, which is a life-threatening condition characterized by a dangerously low body temperature. Medical professionals may use various methods to measure body temperature, including oral thermometers, rectal thermometers, and ear thermometers. If a person's body temperature is found to be below the normal range, they may be treated with measures to raise their body temperature, such as warm blankets or heating pads, and in severe cases, may require hospitalization for further treatment.
Monoterpenes are a group of organic compounds that are found in many essential oils, including those derived from plants such as citrus fruits, mint, and rosemary. They are also found in some herbs and spices, such as thyme and oregano. In the medical field, monoterpenes have been studied for their potential health benefits. Some monoterpenes have been shown to have antimicrobial, anti-inflammatory, and antioxidant properties, which may help to protect against a variety of diseases and conditions. For example, some monoterpenes have been shown to have antiviral activity against viruses such as influenza and herpes simplex virus. Others have been shown to have anti-inflammatory effects, which may help to reduce inflammation and pain in conditions such as arthritis and inflammatory bowel disease. Monoterpenes may also have potential benefits for cardiovascular health. Some monoterpenes have been shown to help to lower blood pressure and improve blood flow, which may help to reduce the risk of heart disease. Overall, monoterpenes are a promising area of research in the medical field, and further studies are needed to fully understand their potential health benefits.
Acrolein is a colorless gas with a pungent, irritating odor. It is a highly reactive compound that is produced naturally in the environment and is also formed during the incomplete combustion of organic materials, such as tobacco smoke and wood fires. In the medical field, acrolein is known to be a toxic substance that can cause a range of adverse health effects, including irritation of the eyes, nose, and throat, as well as damage to the lungs, kidneys, and other organs. It has also been linked to the development of certain types of cancer, including lung cancer and bladder cancer. In addition, acrolein has been shown to have anti-inflammatory and anti-viral properties, and it is being studied for its potential use in the treatment of certain medical conditions.
Thymol is a natural compound that is derived from the essential oil of thyme, a common herb. It has been used in traditional medicine for centuries and has a wide range of potential therapeutic effects. In the medical field, thymol is primarily used as an antiseptic and disinfectant. It has been shown to be effective against a variety of bacteria, viruses, and fungi, making it useful for treating infections and preventing the spread of disease. Thymol is also used in some over-the-counter medications, such as throat lozenges and mouthwashes, to help relieve sore throat and mouth pain. It has been shown to have anti-inflammatory and analgesic properties, which may help to reduce swelling and pain. In addition to its medicinal uses, thymol is also used in the food industry as a flavoring agent and preservative. It is commonly found in spices, seasonings, and baked goods, and is used to give these products a distinctive flavor and aroma. Overall, thymol is a versatile compound with a range of potential therapeutic applications in the medical field. However, more research is needed to fully understand its effects and potential side effects.
Transient Receptor Potential (TRP) channels are a family of non-selective cation channels that are widely expressed in various tissues and cell types throughout the body. These channels are activated by a wide range of stimuli, including changes in temperature, pH, osmolarity, and mechanical forces. TRP channels play important roles in various physiological processes, including sensory perception, pain transmission, and regulation of cell proliferation and differentiation. They are also involved in various pathological conditions, such as inflammation, neurodegeneration, and cancer. In the medical field, TRP channels are of great interest as potential therapeutic targets for a variety of diseases. For example, TRP channels have been implicated in the pathogenesis of chronic pain, and drugs that modulate TRP channel activity are being developed as potential analgesics. Additionally, TRP channels have been shown to play a role in the development and progression of various cancers, and targeting these channels may provide new strategies for cancer treatment.
Menthol
Menthol cigarette
menthol monooxygenase
menthol dehydrogenase
Menthol (data page)
Clown Prince of the Menthol Trailer
NADPH dehydrogenase
Hungária (band)
List of cigarette brands
Menthoxypropanediol
Halls (cough drop)
Pianissimo Peche
Tobacco Products Scientific Advisory Committee
Κ-opioid receptor
Ilene Segalove
Celadrin (joint cream)
Menthone
Hieronymus David Gaubius
Ya mong
Peppermint
Tobacconist
Canadian Classics
Throat lozenge
Health effects of electronic cigarettes
Gold Bond
Mentha longifolia
Flavored tobacco
Je ne mâche pas les mots
Richard Burr
James Reilly (Irish politician)
Menthol - Wikipedia
Addressing Menthol Tobacco Products
Should Menthol Cigarettes Be Banned? : NPR
Menthol poisoning: MedlinePlus Medical Encyclopedia
WINTERGREEN - MENTHOL
Menthol 5.8 mg
Class action suit filed over menthol cigarettes - The Jerusalem Post
FDA to issue plan banning menthol in cigarettes, cigars
Menthol cigarette ban in Canada boosted quit rates, study shows - UPI.com
Menthol cigarette smoking and health, Florida 2007 BRFSS
camphor, eucalyptus, and menthol topical | Cigna
MedlinePlus - Search Results for: CAMPHOR NATURAL OR MENTHOL
Opinion: NYC Should Crack Down on Flavored E-Cigarettes and Menthol
FDA Moves To Ban Menthol Cigarettes And Flavored Cigars
Most youth would quit vaping if flavors, including menthol, were not available, research shows
Helwit Menthol Slim Nicotine Pouches - Northerner DE
Germany - Cigarettes containing menthol capsules banned | WHO FCTC
TRPM8: The Cold and Menthol Receptor - TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades - NCBI...
Menthol Archives - Baller Alert
Herbal Lozenge Menthol Cough Drop 15 lozenges, Zand | VitaSprings.com
FDA plans to ban menthol cigarettes, flavored cigars | ACP Internist
Young Menthol Dez | Artists | Coast 2 Coast Mixtapes
Buy MERIT ULTRA MENTHOL 100 online for USA and Canada customers!
Cheyenne Menthol Pipe Tobacco 16oz 2-Fer - Thompson Cigar
MGC Health Menthol Cough Drops, 80-Count | Big Lots
Activation of the cold-receptor TRPM8 by low levels of menthol in tobacco products - BfR
FDA Moves To Ban Menthol Cigarettes And Flavored Cigars | WMOT
Marlboro MARLBORO SMOOTH MENTHOL BOX 100 MM
- Food Service Rewards
Building evidence for the landmark U.S. ban on menthol cigarettes - Ontario Institute for Cancer Research
Wildfire legislation in House, menthol cigarette manufacturing to cease - KCSU FM
Cigarettes49
- Federal law prohibits cigarettes to be marketed with characterizing flavors, except tobacco or menthol. (cdc.gov)
- 3, 4, 5 Evidence from other countries supports the public health benefits of removing menthol cigarettes from the marketplace. (cdc.gov)
- For example, after laws prohibiting the sale of menthol cigarettes were implemented in Canada, adults who smoked menthol cigarette reported high rates of quit attempts and quit successes. (cdc.gov)
- 3,6 Adults who had smoked menthol cigarettes daily before the law went into effect and tried quitting smoking were more likely to report having quit cigarettes than adults who had smoked non-menthol cigarettes. (cdc.gov)
- Should Menthol Cigarettes Be Banned? (npr.org)
- The U.S. Food and Drug Administration is debating a ban on menthol cigarettes as their slightly minty taste can cover up tobacco's harshness. (npr.org)
- About 80 percent of black smokers prefer menthol cigarettes compared with 22 percent of white smokers. (npr.org)
- menthol cigarettes. (npr.org)
- About 80 percent of black smokers prefer menthol cigarettes. (npr.org)
- What is being described as the world's first class action lawsuit on behalf of people who developed lung cancer from smoking menthol cigarettes has been initiated by Israel's leading anti-tobacco attorney, Amos Hausner, The Jerusalem Post has learned. (jpost.com)
- Research conducted by tobacco companies a decade or more ago to identify additives that increase tobacco addiction showed that menthol did the trick, and the companies made a special effort to market cigarettes with this additive. (jpost.com)
- Foreign research has shown that African Americans become even more addicted to menthol cigarettes than whites do. (jpost.com)
- She started with non-menthol cigarettes and then switched to Montana - smoking up to two packs a day without realizing that menthol caused them to be more addictive and made it very difficult to quit. (jpost.com)
- She had long thought that menthol cigarettes were "less dangerous" than ordinary ones because they did not taste so bad. (jpost.com)
- FILE - Menthol cigarettes and other tobacco products are displayed at a store in San Francisco on May 17, 2018. (abc15.com)
- The U.S. government is set to release its long-awaited plan to ban menthol cigarettes and flavored cigars. (abc15.com)
- Menthol accounts for more than a third of cigarettes sold in the U.S, and the mint flavor is overwhelmingly favored by Black smokers and young people. (abc15.com)
- The combination of menthol's flavor, sensory effects and interaction with nicotine in the brain increases the likelihood that youth who start using menthol cigarettes will progress to regular use, the FDA said. (abc15.com)
- Could banning menthol cigarettes be key to lowering smoking rates overall? (upi.com)
- New research suggests it's possible, after finding that a ban on menthol cigarettes in Canada was linked to a large increase in the number of smokers who quit. (upi.com)
- The impact of the menthol ban in Canada suggests that a similar ban in the United States would have even greater benefits since menthol cigarettes are much more popular among Americans, the researchers said. (upi.com)
- From our findings, we estimate that banning menthol cigarettes in the U.S. would lead an additional 923,000 smokers to quit, including 230,000 African American smokers," said researcher Geoffrey Fong. (upi.com)
- In the United States, there's growing momentum in Congress to enact a national ban on menthol cigarettes, while similar measures are being considered at the state and local levels. (upi.com)
- At the same time, the U.S. Food and Drug Administration faces a court order to respond to a citizen's petition to ban menthol cigarettes by April 29, according to The New York Times. (upi.com)
- Menthol, the most common flavoring for cigarettes in many countries, reduces the harshness of cigarette smoke. (upi.com)
- Canada was one of the first countries to ban menthol cigarettes. (upi.com)
- Scientific reviews conducted by U.S. health experts and the World Health Organization concluded that banning menthol cigarettes would have significant public health benefits. (upi.com)
- In the United States, those benefits might be greatest among Black Americans because menthol cigarettes are used by 85% of Black smokers, which is more than 2.8 times higher than among white smokers. (upi.com)
- Our study demonstrates the substantial benefits of banning menthol cigarettes," Fong said in a university press release. (upi.com)
- Women, racial/ethnic minorities, and individuals reporting a greater frequency of mental distress are more likely to smoke menthol versus nonmenthol cigarettes. (nih.gov)
- Sadly, but not surprisingly, more than half of youth smokers use menthol cigarettes. (citylimits.org)
- In addition to the menthol loophole, we also now have a new front in the war against flavored tobacco: e-cigarettes. (citylimits.org)
- The U.S. Food and Drug Administration says it is moving to ban menthol cigarettes and flavored cigars, based on the evidence of the addictiveness and harm of the products. (kcbx.org)
- Tobacco companies have long targeted African Americans with advertising for menthol cigarettes. (kcbx.org)
- Banning menthol - the last allowable flavor - in cigarettes and banning all flavors in cigars will help save lives, particularly among those disproportionately affected by these deadly products," acting FDA Commissioner Dr. Janet Woodcock said in a statement Thursday. (kcbx.org)
- The agency said it will focus on keeping the products off the market, as opposed to targeting individual use: "The FDA cannot and will not enforce against individual consumer possession or use of menthol cigarettes or any tobacco product. (kcbx.org)
- While the FDA made a similar announcement to prohibit menthol cigarettes in 2018 during the Trump administration, a ban did not come to pass. (kcbx.org)
- The FDA said about 18.6 million people in the U.S. currently smoke menthol cigarettes, but their use is uneven: Almost 85% of Black smokers use menthol cigarettes, compared with 30% of white smokers. (kcbx.org)
- It pointed to an FDA finding that if menthol cigarettes had been removed from the marketplace in 2010, "by 2020, roughly 17,000 premature deaths would have been avoided and about 2.3 million people would not have started smoking. (kcbx.org)
- It cited a study suggesting that banning menthol cigarettes in the U.S. "would lead an additional 923,000 smokers to quit, including 230,000 African Americans in the first 13 to 17 months after a ban goes into effect. (kcbx.org)
- The African American Tobacco Control Leadership Council has long pushed to ban menthol cigarettes. (kcbx.org)
- OCTOBER 2012 -The Federal Office of Consumer Protection and Food Safety has rejected an application by a tobacco company to sell cigarettes containing menthol capsules in the filter, on the grounds of public health. (who.int)
- Menthol, typically found and used in cigarettes, may be banned by the end of this week. (balleralert.com)
- The Food and Drug Administration (FDA) is working toward putting an end to menthol being used in cigarettes, as it would significantly prevent health issues related to menthol in the Black community. (balleralert.com)
- The study has assessed the minimum menthol contents in cigarettes required for TRPM8 activation. (bund.de)
- U.S. health regulators announced a new effort Thursday to ban menthol cigarettes. (wmot.org)
- When the U.S. Food and Drug Administration (FDA) announced in April 2022 that it was moving forward with a ban on menthol cigarettes , FDA Commissioner Dr. Robert Califf said the ban would help smokers quit, stop young people from starting smoking, and save lives. (oicr.on.ca)
- Canada became one of the first countries to ban menthol cigarettes when all provinces introduced bans between 2015 and 2018, and then became the first country where a menthol ban has been evaluated on whether it leads smokers to quit. (oicr.on.ca)
- In their initial analysis published in April 2021 , Dr. Fong and his ITC Project colleagues showed that banning menthol cigarettes made Canadian menthol smokers significantly more likely to quit than those who smoked non-menthol cigarettes. (oicr.on.ca)
Including menthol products1
- Developing educational initiatives that describe targeted tobacco industry marketing tactics and warn about the risks of tobacco product use, including menthol products. (cdc.gov)
Flavored tobacco products2
Flavor8
- And the one flavor they did not touch was menthol. (npr.org)
- Menthol is used to add peppermint flavor to candy and other products. (medlineplus.gov)
- Menthol is the only cigarette flavor that was not banned under the 2009 law that gave the FDA authority over tobacco products. (abc15.com)
- But the most common flavor, menthol, was exempted. (citylimits.org)
- Adolescents and young adults using flavors with cooling additives, such as "fruit ice," reported higher odds of discontinuing use under a tobacco-only product standard compared with users who preferred menthol flavor only, said Tackett. (daytondailynews.com)
- The "fruit ice" flavor refers to e-cigarette flavors with a fruit base characterizing flavor with a cooling additive such as menthol or a synthetic cooling agent. (daytondailynews.com)
- Pack your pipe and savor the flavor of the good ol' USA with this Cheyenne Menthol Pipe Tobacco 16oz 2-fer Deal! (thompsoncigar.com)
- Alleviate your sore throat in seconds with these menthol flavor cough drops from MGC Health. (biglots.com)
COUGH DROP3
- VitaSprings does not imply any medical claims from the customer reviews on this Herbal Lozenge Menthol Cough Drop product on this website. (vitasprings.com)
- Write a Review on this Herbal Lozenge Menthol Cough Drop product and share your experience or opinion with other customers. (vitasprings.com)
- Buy Herbal Lozenge Menthol Cough Drop from Zand at VitaSprings, and we guarantee you a safe, secure online shopping experience! (vitasprings.com)
20181
- To assess the ban's impact, Fong and his colleagues surveyed nearly 1,100 non-menthol and 138 menthol smokers in 2016, before the ban and in 2018, after the ban. (upi.com)
Camphor8
- What is the most important information I should know about camphor, eucalyptus, and menthol topical? (cigna.com)
- Camphor, eucalyptus, and menthol topical is a combination product that is applied to the skin. (cigna.com)
- Camphor, eucalyptus, and menthol topical may also be used for purposes not listed in this medication guide. (cigna.com)
- What should I discuss with my healthcare provider before using camphor, eucalyptus, and menthol topical? (cigna.com)
- How should I use camphor, eucalyptus, and menthol topical? (cigna.com)
- Since camphor, eucalyptus, and menthol is used when needed, it does not have a dosing schedule. (cigna.com)
- What should I avoid while using camphor, eucalyptus, and menthol topical? (cigna.com)
- What are the possible side effects of camphor, eucalyptus, and menthol topical? (cigna.com)
Flavors1
- The FDA said that "menthol masks unpleasant flavors and harshness of tobacco products, making them easier to start using. (kcbx.org)
WINTERGREEN1
- Mint" and "wintergreen" are the new menthol. (citylimits.org)
Peppermint oil3
- citation needed] Menthol occurs naturally in peppermint oil (along with a little menthone, the ester menthyl acetate and other compounds), obtained from Mentha × piperita (peppermint). (wikipedia.org)
- Natural menthol is obtained by freezing peppermint oil. (wikipedia.org)
- The aim of the present study was to assess whether the gastric peristalsis -suppressing effect is dose -dependently induced by L- menthol , the major constituent of peppermint oil, and to determine the recommended dose of an L- menthol preparation. (bvsalud.org)
Nicotine dependence3
- Learn about menthol and its relationship to tobacco product use and nicotine dependence among young people, how menthol products are disproportionately marketed to specific groups of people, and the risks of using tobacco products. (cdc.gov)
- Learn about menthol and its relationship to tobacco use, nicotine dependence, and reduced cessation success. (cdc.gov)
- To examine associations between menthol cigarette smoking and nicotine dependence, quit attempts, and physical and mental health. (nih.gov)
TRPM83
- Menthol also lowers blood pressure and antagonizes vasoconstriction through TRPM8 activation. (wikipedia.org)
- Menthol in cigarette smoke activates the cold-receptor TRPM8 and mediates a "cooling effect" that is independent from its mint-like aroma. (bund.de)
- A measurable activation of TRPM8 is expected when the content of menthol exceeds 50 μg per cigarette. (bund.de)
Harmful2
- Menthol can be harmful in large amounts. (medlineplus.gov)
- But the American Medical Association said the evidence is clear on the harmful impacts of menthols and called the FDA's decision long overdue. (kcbx.org)
Fong4
- The ban "did not lead to a high level of illicit menthol cigarette purchasing, which has been a concern by regulators considering a menthol ban," said Fong, who added that "fewer than 10% of menthol smokers reported still smoking a menthol brand after the ban. (upi.com)
- The enormous success of the Canadian menthol ban makes it even clearer now that the U.S. should finally ban menthol, which the tobacco industry has used for decades to attract new smokers and to keep many of them as customers, especially among the African American community," Fong said. (upi.com)
- Applying that 7.3 per cent difference to the more than 18 million menthol smokers in the U.S. gave Dr. Fong and colleagues their 1.3 million estimate. (oicr.on.ca)
- Our study is the most complete evaluation of Canada's menthol cigarette ban," Dr. Fong said. (oicr.on.ca)
Neurons2
- Some studies show that menthol acts as a GABAA receptor positive allosteric modulator and increases GABAergic transmission in PAG neurons. (wikipedia.org)
- Most cold-sensitive neurons are also sensitive to the ubiquitous cooling compound menthol, a cyclic terpene alcohol found in mint leaves [ 10 ]. (nih.gov)
Compounds1
- Ingredients of candies and chewing gums that may cause irritant or allergic contact stomatitis include flavoring agents (rare) (cinnamon compounds, menthol) and propolis, a strong sensitizer often used in the oral cavity because of its antiseptic properties. (medscape.com)
Induce1
- It is well known that moderate concentrations of menthol induce a pleasant cool sensation, such as that felt when using menthol-containing products such as candy and vapo-rubs. (nih.gov)
African-Americans1
- The ban by the FDA is long overdue to protect the health of African Americans and to reduce the deleterious impact of menthol smoking and tobacco use overall on America's health," he said. (kcbx.org)
World Health Organ1
- Smoking kills about 45,000 Canadians every year, and public health authorities including the World Health Organization have long advocated for banning menthols, which have added flavouring and are popular among young smokers, women and some minority groups. (oicr.on.ca)
Cigarette ban1
- As Chief Principal Investigator of the International Tobacco Control Policy Evaluation Project (ITC Project) at the University of Waterloo, he led an evaluation of Canada's recent menthol cigarette ban that was cited by the FDA as it explored a U.S. menthol ban. (oicr.on.ca)
Products12
- Licensing retailers who sell any types of tobacco products, to better understand who is selling menthol and other tobacco products and to aid with equitable implementation and enforcement of tobacco control policies. (cdc.gov)
- Prohibiting sales of menthol and other tobacco products. (cdc.gov)
- Raising the price of menthol and other tobacco products and prohibiting price discounts. (cdc.gov)
- Curbing the advertising and marketing of menthol and other tobacco products to young people. (cdc.gov)
- Ensuring that all people who use tobacco products have access to evidence-based quitting resources , including counseling and medication , to help them successfully quit, and tailoring of cessation messages to better reach people who use menthol products. (cdc.gov)
- Implement school prevention and cessation programs that are free from tobacco industry influence, that include education about menthol products, and that can be tailored to groups that the tobacco industry targets with menthol marketing. (cdc.gov)
- Learn about how menthol products are disproportionately marketed to and used by specific groups of people. (cdc.gov)
- Other products may also contain menthol. (medlineplus.gov)
- The menthol found in many over-the-counter products is usually watered down and mixed with other ingredients. (medlineplus.gov)
- The suit further argued that Dubek was guilty of "misleading consumers" by not warning that menthol additives make their products more addictive. (jpost.com)
- The FDA estimates that eliminating menthol products would reduce smoking rates by 15% within 40 years. (abc15.com)
- Tobacco products with menthol can also be more addictive and harder to quit by enhancing the effects of nicotine. (kcbx.org)
Significantly1
- Menthol smokers who had quit smoking before the menthol ban were also significantly less likely than non-menthol smokers who had quit smoking to have started smoking again, according to the study published online this week in the journal Tobacco Control. (upi.com)
Percentage2
- Japanese menthol also contains a small percentage of the 1-epimer neomenthol. (wikipedia.org)
- African American adults have the highest percentage of menthol cigarette use compared with other racial and ethnic groups, according to the Centers for Disease Control and Prevention. (kcbx.org)
Topical1
- Menthol is widely used in dental care as a topical antibacterial agent, effective against several types of streptococci and lactobacilli. (wikipedia.org)
Irritation3
- Menthol has local anesthetic and counterirritant qualities, and it is widely used to relieve minor throat irritation. (wikipedia.org)
- However, when present at higher doses menthol can be noxious, causing burning, irritation, and pain [ 10-12 ]. (nih.gov)
- Although reported to be human irritants, menthol (50%), and p-xylenol (10%) were negative for both irritation and sensitization at the highest concentrations tested. (cdc.gov)
Synthetic2
- Total world production of menthol in 1998 was 12,000 tonnes of which 2,500 tonnes was synthetic. (wikipedia.org)
- In 2005, the annual production of synthetic menthol was almost double. (wikipedia.org)
Researchers1
- Indeed, the researchers hypothesized that menthol exerted its actions on "an enzyme" that was involved in the activation of these nerves [ 13 ]. (nih.gov)
Addictive2
Product1
- Ask a product specific question about Cheyenne Menthol Pipe Tobacco 16oz 2-Fer . (thompsoncigar.com)
Mint2
- Menthol is an organic compound, more specifically a monoterpenoid, made synthetically or obtained from the oils of corn mint, peppermint, or other mints. (wikipedia.org)
- Mentha arvensis (wild mint) is the primary species of mint used to make natural menthol crystals and natural menthol flakes[citation needed]. (wikipedia.org)
Adverse1
- Adverse events in the L- menthol dose groups occurred with similar frequencies in the placebo group. (bvsalud.org)
Found1
- Together, they found that 22.3 per cent of menthol smokers quit following the ban, compared to 15 per cent of non-menthol smokers. (oicr.on.ca)
Pleasant1
- Menthol not only gives smokers a "more pleasant" feeling in their mouths and throats, but also keeps tobacco smoke - with its many toxins - inside the lungs longer, making it even more dangerous. (jpost.com)
Cool4
- In seminal studies conducted by Hensel and Zotterman in the 1950s, menthol elicited its "cool" sensation by increasing the threshold temperature for activation of cold receptors [ 13 ]. (nih.gov)
- This smooth blend of velvety Burley and tangy Virginia is finished with a pleasantly cool splash of menthol. (thompsoncigar.com)
- Stimulation of upper airway cold receptors on the trigeminal nerve (TGN) with TGN agonists such as menthol or cool air to the face/nose has been hypothesized to reduce breathlessness by decreasing IND. (lu.se)
- Otherwise, TGN stimulation with menthol or cool air to the face/note had no effect on measures of IND in humans. (lu.se)
Health1
- The menthol ban is likely to have a major impact on the health of Black Americans, who smoke menthols at much higher rates than other Americans and who have been targeted by aggressive menthol tobacco marketing. (oicr.on.ca)
Black2
- DAVE CHAPPELLE: Why do black people love menthols so much? (npr.org)
- Eighty-five percent of Black adult smokers and 64 percent of Latinos who smoke buy menthols. (citylimits.org)
Similar1
- Menthol also shares anaesthetic properties similar to propofol by modulating the same sites of the GABAA receptor. (wikipedia.org)
Include1
- So the question is: Should the FDA - they have an advisory panel out there - look carefully at menthol, and should they include menthol in the flavorings that are banned? (npr.org)
Study4
- Three weeks later, the FDA announced that it would develop a rule to ban menthol , citing the ITC study. (oicr.on.ca)
- This newest study builds on the ITC Project's previous work by combining ITC data across 7 provinces with data from another project that also evaluated the impact of the menthol ban only in Ontario. (oicr.on.ca)
- Multicenter phase II randomized study evaluating dose-response of antiperistaltic effect of L-menthol sprayed onto the gastric mucosa for upper gastrointestinal endoscopy. (bvsalud.org)
- In this phase II, multicenter, double-blind, dose -response study, 131 eligible patients were randomly assigned to receive 20 mL of 0.4% L- menthol (n = 32), 0.8% L- menthol (n = 35), 1.6% L- menthol (n = 30), or placebo (n = 34). (bvsalud.org)
Studies2
- Studies show that tobacco companies undertake predatory tactics to hook blacks and Latinos on menthol. (citylimits.org)
- Further Phase III studies are needed to establish the superiority of 0.8% L- menthol over placebo. (bvsalud.org)
Canada1
- Buy MERIT ULTRA MENTHOL 100 online for USA and Canada customers! (4cigarettes.net)
Brand2
Impact1
- And I think that if there were no menthol flavoring, it would have a dramatic impact in keeping kids from starting to smoke. (npr.org)
Main1
- The main form of menthol occurring in nature is (−)-menthol, which is assigned the (1R,2S,5R) configuration. (wikipedia.org)