An alcohol produced from mint oils or prepared synthetically.
Agents, usually topical, that relieve itching (pruritus).
A subgroup of TRP cation channels named after melastatin protein. They have the TRP domain but lack ANKYRIN repeats. Enzyme domains in the C-terminus leads to them being called chanzymes.
A plant genus of the family LAMIACEAE that is the source of peppermint oil.
Substances and products derived from NICOTIANA TABACUM.
Cellular receptors which mediate the sense of temperature. Thermoreceptors in vertebrates are mostly located under the skin. In mammals there are separate types of thermoreceptors for cold and for warmth and NOCICEPTORS which detect cold or heat extreme enough to cause pain.
The sensation of cold, heat, coolness, and warmth as detected by THERMORECEPTORS.
Activity involved in transfer of goods from producer to consumer or in the exchange of services.
An absence of warmth or heat or a temperature notably below an accustomed norm.
Compounds with a core of 10 carbons generally formed via the mevalonate pathway from the combination of 3,3-dimethylallyl pyrophosphate and isopentenyl pyrophosphate. They are cyclized and oxidized in a variety of ways. Due to the low molecular weight many of them exist in the form of essential oils (OILS, VOLATILE).
Acrolein is a toxic and highly reactive organic compound that is produced during the breakdown of some amino acids and fatty acids, and has been linked to various health problems, including respiratory irritation and inflammation.
The aggregate business enterprise of agriculture, manufacture, and distribution related to tobacco and tobacco-derived products.
A phenol obtained from thyme oil or other volatile oils used as a stabilizer in pharmaceutical preparations, and as an antiseptic (antibacterial or antifungal) agent. It was formerly used as a vermifuge.
A broad group of eukaryotic six-transmembrane cation channels that are classified by sequence homology because their functional involvement with SENSATION is varied. They have only weak voltage sensitivity and ion selectivity. They are named after a DROSOPHILA mutant that displayed transient receptor potentials in response to light. A 25-amino-acid motif containing a TRP box (EWKFAR) just C-terminal to S6 is found in TRPC, TRPV and TRPM subgroups. ANKYRIN repeats are found in TRPC, TRPV & TRPN subgroups. Some are functionally associated with TYROSINE KINASE or TYPE C PHOSPHOLIPASES.
Drugs that act locally on cutaneous or mucosal surfaces to produce inflammation; those that cause redness due to hyperemia are rubefacients; those that raise blisters are vesicants and those that penetrate sebaceous glands and cause abscesses are pustulants; tear gases and mustard gases are also irritants.
Sensation of enjoyment or gratification.
Systematic organization, storage, retrieval, and dissemination of specialized information, especially of a scientific or technical nature (From ALA Glossary of Library and Information Science, 1983). It often involves authenticating or validating information.

The posterior nasal nerve plays an important role on cardiopulmonary reflexes to nasal application of capsaicin, distilled water and l-menthol in anesthetized dogs. (1/240)

The sensory innervation of the cardiopulmonary reflexes to nasal application of capsaicin (CAPS), distilled water (DW) and l-menthol (LM) was studied in anesthetized dogs breathing through tracheostomy. A marked cardiopulmonary reflex was observed by CAPS and DW into the nasal cavity, while a prolongation of expiration was induced by LM. All these reflexes were significantly decreased by bilateral section of the posterior nasal nerve (PNN) and completely abolished by topical nasal anesthesia with lidocaine. Responses of the whole nerve activity of the PNN to these substances corresponded to the magnitude of the reflexes. These results indicate that PNN afferents play an important role on the reflex elicitation of the noxious, water and cold stimuli from the nasal cavity.  (+info)

Metabolism of (R)-(+)-pulegone and (R)-(+)-menthofuran by human liver cytochrome P-450s: evidence for formation of a furan epoxide. (2/240)

(R)-(+)-Pulegone, a monoterpene constituent of pennyroyal oil, is a hepatotoxin that has been used in folklore medicine as an abortifacient despite its potential lethal effects. Pulegone is metabolized by human liver cytochrome P-450s to menthofuran, a proximate hepatotoxic metabolite of pulegone. Expressed human liver cytochrome (CYP) P-450s (1A2, 2A6, 2C9, 2C19, 2D6, 2E1, and 3A4) were tested for their ability to catalyze the oxidations of pulegone and menthofuran. Expressed CYP2E1, CYP1A2, and CYP2C19 oxidized pulegone to menthofuran, with respective Km and Vmax values of 29 microM and 8.4 nmol/min/nmol P-450 for CYP2E1, 94 microM and 2.4 nmol/min/nmol P-450 for CYP1A2, and 31 microM and 1.5 nmol/min/nmol P-450 for CYP2C19. The human liver P-450s involved in the metabolism of menthofuran are the same as pulegone except for the addition of CYP2A6. These P-450s were found to oxidize menthofuran to a newly identified metabolite, 2-hydroxymenthofuran, which is an intermediate in the formation of the known metabolites mintlactone and isomintlactone. Based on studies with 18O2 and H218O, 2-hydroxymenthofuran arises predominantly from a dihydrodiol formed from a furan epoxide. CYP2E1, CYP1A2, and CYP2C19 oxidized menthofuran with respective Km and Vmax values of 33 microM and 0.43 nmol/min/nmol P-450 for CYP2E1, 57 microM and 0.29 nmol/min/nmol P-450 for CYP1A2, and 62 microM and 0.26 nmol/min/nmol P-450 for CYP2C19.  (+info)

Developmental regulation of monoterpene biosynthesis in the glandular trichomes of peppermint. (3/240)

Monoterpene production in peppermint (Mentha x piperita L.) glandular trichomes is determined by the rate of biosynthesis, as determined by (14)CO(2) incorporation, and is restricted to leaves 12 to 20 d of age. Using oil glands isolated from peppermint leaves of different ages, in vitro assay of the eight sequential enzymes responsible for the biosynthesis of the principal monoterpene (-)-menthol indicated that all but one biosynthetic enzyme had a very similar developmental profile. Activities were highest in leaves 12 to 20 d of age, with a sharp peak centered at 15 d. The exception, (-)-menthone reductase, the last enzyme of the pathway, exhibited a later peak of activity, which was centered at approximately 21 d. The correlation between in vitro enzyme activity and the rate of biosynthesis measured in vivo suggests that monoterpene formation is controlled mainly by the coordinately regulated activity of the relevant biosynthetic enzymes. Developmental immunoblotting of limonene synthase, which catalyzes the committed step of the pathway, demonstrated a direct correlation between enzyme activity and enzyme protein, suggesting that the dynamic time course for the remaining pathway enzyme activities also reflects the corresponding protein levels. RNA-blot analyses indicated that the genes encoding enzymes of the early pathway steps are transcriptionally activated in a coordinated fashion, with a time course superimpossible with activity measurements and immunoblot data. These results demonstrating coincidental temporal changes in enzyme activities, enzyme protein level, and steady-state transcript abundances indicate that most of the monoterpene biosynthetic enzymes in peppermint are developmentally regulated at the level of gene expression.  (+info)

Amplification of odor-induced Ca(2+) transients by store-operated Ca(2+) release and its role in olfactory signal transduction. (4/240)

A critical role of Ca(2+) in vertebrate olfactory receptor neurons (ORNs) is to couple odor-induced excitation to intracellular feedback pathways that are responsible for the regulation of the sensitivity of the sense of smell, but the role of intracellular Ca(2+) stores in this process remains unclear. Using confocal Ca(2+) imaging and perforated patch recording, we show that salamander ORNs contain a releasable pool of Ca(2+) that can be discharged at rest by the SERCA inhibitor thapsigargin and the ryanodine receptor agonist caffeine. The Ca(2+) stores are spatially restricted; emptying produces compartmentalized Ca(2+) release and capacitative-like Ca(2+) entry in the dendrite and soma but not in the cilia, the site of odor transduction. We deplete the stores to show that odor stimulation causes store-dependent Ca(2+) mobilization. This odor-induced Ca(2+) release does not seem to be necessary for generation of an immediate electrophysiological response, nor does it contribute significantly to the Ca(2+) transients in the olfactory cilia. Rather, it is important for amplifying the magnitude and duration of Ca(2+) transients in the dendrite and soma and is thus necessary for the spread of an odor-induced Ca(2+) wave from the cilia to the soma. We show that this amplification process depends on Ca(2+)-induced Ca(2+) release. The results indicate that stimulation of ORNs with odorants can produce Ca(2+) mobilization from intracellular stores without an immediate effect on the receptor potential. Odor-induced, store-dependent Ca(2+) mobilization may be part of a feedback pathway by which information is transferred from the distal dendrite of an ORN to its soma.  (+info)

'Microsmatic' primates revisited: olfactory sensitivity in the squirrel monkey. (5/240)

Using a conditioning paradigm, the olfactory sensitivity of three squirrel monkeys to nine odorants representing different chemical classes as well as members of a homologous series of substances was investigated. The animals significantly discriminated dilutions as low as 1:10,000 n-propionic acid, 1:30,000 n-butanoic acid and n-pentanoic acid, 1:100,000 n-hexanoic acid, 1:1Mio n-heptanoic acid, 1:30, 000 1-pentanol, 1:300,000 1,8-cineole, 1:1Mio n-heptanal and 1:30Mio amyl acetate from the near-odorless solvent, with single individuals scoring even slightly better. The results showed (i) the squirrel monkey to have an unexpectedly high olfactory sensitivity, which for some substances matches or even is better than that of species such as the rat or the dog, and (ii) a significant negative correlation between perceptibility in terms of olfactory detection thresholds and carbon chain length of carboxylic acids. These findings support the assumptions that olfaction may play a significant and hitherto underestimated role in the regulation of primate behavior, and that the concept of primates as primarily visual and 'microsmatic' animals needs to be revised.  (+info)

Purification and characterization of a Baeyer-Villiger mono-oxygenase from Rhodococcus erythropolis DCL14 involved in three different monocyclic monoterpene degradation pathways. (6/240)

A Baeyer-Villiger mono-oxygenase (BVMO), catalysing the NADPH- and oxygen-dependent oxidation of the monocyclic monoterpene ketones 1-hydroxy-2-oxolimonene, dihydrocarvone and menthone, was purified to homogeneity from Rhodococcus erythropolis DCL14. Monocyclic monoterpene ketone mono-oxygenase (MMKMO) is a monomeric enzyme of molecular mass 60 kDa. It contains 1 mol of FAD/monomer as the prosthetic group. The N-terminal amino acid sequence showed homology with many other NADPH-dependent and FAD-containing (Type 1) BVMOs. Maximal enzyme activity was measured at pH 9 and 35 degrees C. MMKMO has a broad substrate specificity, catalysing the lactonization of a large number of monocyclic monoterpene ketones and substituted cyclohexanones. The natural substrates 1-hydroxy-2-oxolimonene, dihydrocarvone and menthone were converted stoichiometrically into 3-isopropenyl-6-oxoheptanoate (the spontaneous rearrangement product of the lactone formed by MMKMO), 4-isopropenyl-7-methyl-2-oxo-oxepanone and 7-isopropyl-4-methyl-2-oxo-oxepanone respectively. The MMKMO-catalysed conversion of iso-dihydrocarvone showed an opposite regioselectivity to that of dihydrocarvone; in this case, 6-isopropenyl-3-methyl-2-oxo-oxepanone was formed as the product. MMKMO converted all enantiomers of the natural substrates with almost equal efficiency. MMKMO is involved in the conversion of the monocyclic monoterpene ketone intermediates formed in the degradation pathways of all stereoisomers of three different monocyclic monoterpenes, i.e. limonene, (dihydro)carveol and menthol.  (+info)

Role of C-5 chiral center in R-(+)-pulegone-mediated hepatotoxicity: metabolic disposition and toxicity of 5, 5-dimethyl-2-(1-Methylethylidene)-cyclohexanone in rats. (7/240)

Metabolic disposition of 5, 5-dimethyl-2-(1-methylethylidene)-cyclohexanone (I) was examined in rats. Compound (I) was administered orally (250 mg/kg of body weight/day) to rats for 5 days. The following urinary metabolites were isolated and identified: 4,5,6,7-tetrahydro-3,6, 6-trimethylbenzofuran (III), 3,3-dimethylcyclohexanone (VI), 5, 5-dimethyl-3-hydroxy-2-(1-methylethylidene)-cyclohexanone (X), 5, 5-dimethyl-2-(1-hydroxymethylethyl)-cyclohexanone (IX), 3-hydroxy-5-hydroxymethyl-5-methyl-2-(1-methylethylidene)-cyclo hexano ne (XI), 5,6-dihydro-3,6,6-trimethyl-2(4H)-benzofuranone (VIII), and 5,5-dimethyl-3-hydroxy-2-(1-carboxy ethylidene)-cyclohexanone (XIII). Incubation of compound (I) with phenobarbital (PB)-induced rat liver microsomes in the presence of NADPH resulted in the formation of a metabolite, tentatively identified as a furanoterpene (III) based on proton magnetic resonance, gas chromatography, and gas chromatography-mass spectroscopy analyses. The formation of III was inhibited to a significant extent by carbon monoxide, metyrapone, SKF 525-A, and cytochrome c, suggesting the participation of PB-induced microsomal cytochrome P-450 system in the conversion of I to III. Compound I gave type I spectral change in the PB-induced liver microsomes and the dissociation constant (Ks) for I was 38.5 microM. Intraperitoneal administration of a single dose (250 mg/kg) of I to rats resulted in 26, 23, and 41% decreases in the levels of cytochrome P-450, glucose-6-phosphatase, and aminopyrine N-demethylase, respectively, at the end of 24 h. During this period, a 11-fold increase in serum glutamate pyruvate transaminase level was also observed. However, a decrease in the level of cytochrome P-450 and glucose-6-phosphatase, and an increase in serum glutamate pyruvate transaminase values were comparatively more pronounced when R-(+)-pulegone (250 mg/kg) or CCl(4) (0.6 ml/kg) was administered to rats. Pretreatment of rats with PB potentiated the hepatotoxicity caused by I, whereas pretreatment with 3-methylcholanthrene protected from it. This suggests that PB-induced cytochrome P-450-catalyzed reactive metabolites may be responsible for the toxic effects caused by I.  (+info)

Inhibition of plant asparagine synthetase by monoterpene cineoles. (8/240)

Asparagine (Asn) synthetase (AS) is the key enzyme in Asn biosynthesis and plays an important role in nitrogen mobilization. Despite its important physiological function, little research has been done documenting inhibitors of plant AS. Plant growth inhibition caused by the natural monoterpene 1,4-cineole and its structurally related herbicide cinmethylin was reversed 65% and 55%, respectively, by providing 100 microM Asn exogenously. Reversion of the phytotoxic effect was dependent on the concentration of Asn. The presence of either 1,4-cineole or cinmethylin stimulated root uptake of [(14)C]Asn by lettuce (Lactuca sativa) seedlings. Although the physiological responses suggested that both compounds affected Asn biosynthesis, biochemical analysis of AS activity showed that the natural monoterpene was a potent inhibitor (I(50) = approximately 0. 5 microM) of the enzyme, whereas the commercial product was not inhibitory up to levels of 10 mM. Analysis of the putative metabolite, 2-hydroxy-1,4-cineole, showed that the cis-enantiomer was much more active than the trans-enantiomer, suggesting that the hydroxyl group was involved in the specific ligand/active site interaction. This is the first report that AS is a suitable herbicide target site, and that cinmethylin is apparently a proherbicide that requires metabolic bioactivation via cleavage of the benzyl-ether side chain.  (+info)

Menthol is a naturally occurring compound that is commonly found in mint plants. It is often used in over-the-counter medications and personal care products, such as cough drops, toothpaste, and mouthwashes, due to its ability to provide a cooling sensation on the skin and in the mouth. In the medical field, menthol is used for its analgesic (pain-relieving) and anti-inflammatory properties. It is sometimes used topically to relieve pain and itching associated with conditions such as insect bites, sunburn, and eczema. Menthol is also used in some medications to treat respiratory conditions, such as coughs and colds, by acting as a decongestant and expectorant. However, it is important to note that menthol can cause irritation and allergic reactions in some people, and it should be used with caution, especially in individuals with sensitive skin or respiratory conditions. Additionally, some studies have suggested that menthol may have negative effects on lung function in individuals with asthma or chronic obstructive pulmonary disease (COPD), so it is important to consult with a healthcare provider before using menthol-containing products.

Antipruritics are medications that are used to relieve itching or pruritus. Pruritus is a common symptom of many medical conditions, including skin disorders, liver disease, kidney disease, and neurological disorders. Antipruritics work by blocking the transmission of itch signals from the skin to the brain, or by reducing the production of substances that cause itching. Examples of antipruritics include antihistamines, corticosteroids, and opioid antagonists. These medications are often used to treat conditions such as eczema, psoriasis, and hives, as well as to relieve the itching associated with certain types of cancer treatments.

TRPM (transient receptor potential melastatin) cation channels are a family of non-selective cation channels that are activated by a variety of stimuli, including temperature, mechanical stress, and chemical compounds. These channels are expressed in a wide range of cell types, including neurons, smooth muscle cells, and immune cells. TRPM channels play important roles in a variety of physiological processes, including sensory perception, regulation of body temperature, and control of cell volume. For example, TRPM8 channels are activated by cold temperatures and are involved in the sensation of cold. TRPV1 channels are activated by heat and are involved in the sensation of pain. TRPM2 channels are involved in the regulation of body temperature and the response to oxidative stress. In the medical field, TRPM channels have been implicated in a number of diseases and conditions, including pain, inflammation, and neurodegenerative disorders. For example, TRPV1 channels have been shown to play a role in the development of inflammatory pain, and TRPM2 channels have been implicated in the pathogenesis of Alzheimer's disease. In addition, TRPM channels are being studied as potential targets for the development of new therapeutic agents for a variety of conditions.

In the medical field, "cold temperature" refers to a body temperature that is below the normal range of 98.6°F (37°C). This can be caused by a variety of factors, including exposure to cold temperatures, certain medical conditions, or the use of certain medications. A person with a cold temperature may experience symptoms such as shivering, feeling weak or fatigued, and having difficulty concentrating. In severe cases, a cold temperature can lead to hypothermia, which is a life-threatening condition characterized by a dangerously low body temperature. Medical professionals may use various methods to measure body temperature, including oral thermometers, rectal thermometers, and ear thermometers. If a person's body temperature is found to be below the normal range, they may be treated with measures to raise their body temperature, such as warm blankets or heating pads, and in severe cases, may require hospitalization for further treatment.

Monoterpenes are a group of organic compounds that are found in many essential oils, including those derived from plants such as citrus fruits, mint, and rosemary. They are also found in some herbs and spices, such as thyme and oregano. In the medical field, monoterpenes have been studied for their potential health benefits. Some monoterpenes have been shown to have antimicrobial, anti-inflammatory, and antioxidant properties, which may help to protect against a variety of diseases and conditions. For example, some monoterpenes have been shown to have antiviral activity against viruses such as influenza and herpes simplex virus. Others have been shown to have anti-inflammatory effects, which may help to reduce inflammation and pain in conditions such as arthritis and inflammatory bowel disease. Monoterpenes may also have potential benefits for cardiovascular health. Some monoterpenes have been shown to help to lower blood pressure and improve blood flow, which may help to reduce the risk of heart disease. Overall, monoterpenes are a promising area of research in the medical field, and further studies are needed to fully understand their potential health benefits.

Acrolein is a colorless gas with a pungent, irritating odor. It is a highly reactive compound that is produced naturally in the environment and is also formed during the incomplete combustion of organic materials, such as tobacco smoke and wood fires. In the medical field, acrolein is known to be a toxic substance that can cause a range of adverse health effects, including irritation of the eyes, nose, and throat, as well as damage to the lungs, kidneys, and other organs. It has also been linked to the development of certain types of cancer, including lung cancer and bladder cancer. In addition, acrolein has been shown to have anti-inflammatory and anti-viral properties, and it is being studied for its potential use in the treatment of certain medical conditions.

Thymol is a natural compound that is derived from the essential oil of thyme, a common herb. It has been used in traditional medicine for centuries and has a wide range of potential therapeutic effects. In the medical field, thymol is primarily used as an antiseptic and disinfectant. It has been shown to be effective against a variety of bacteria, viruses, and fungi, making it useful for treating infections and preventing the spread of disease. Thymol is also used in some over-the-counter medications, such as throat lozenges and mouthwashes, to help relieve sore throat and mouth pain. It has been shown to have anti-inflammatory and analgesic properties, which may help to reduce swelling and pain. In addition to its medicinal uses, thymol is also used in the food industry as a flavoring agent and preservative. It is commonly found in spices, seasonings, and baked goods, and is used to give these products a distinctive flavor and aroma. Overall, thymol is a versatile compound with a range of potential therapeutic applications in the medical field. However, more research is needed to fully understand its effects and potential side effects.

Transient Receptor Potential (TRP) channels are a family of non-selective cation channels that are widely expressed in various tissues and cell types throughout the body. These channels are activated by a wide range of stimuli, including changes in temperature, pH, osmolarity, and mechanical forces. TRP channels play important roles in various physiological processes, including sensory perception, pain transmission, and regulation of cell proliferation and differentiation. They are also involved in various pathological conditions, such as inflammation, neurodegeneration, and cancer. In the medical field, TRP channels are of great interest as potential therapeutic targets for a variety of diseases. For example, TRP channels have been implicated in the pathogenesis of chronic pain, and drugs that modulate TRP channel activity are being developed as potential analgesics. Additionally, TRP channels have been shown to play a role in the development and progression of various cancers, and targeting these channels may provide new strategies for cancer treatment.

The main form of menthol occurring in nature is (−)-menthol, which is assigned the (1R,2S,5R) configuration. Menthol has local ... Menthol also acts as a weak κ-opioid receptor agonist. Natural menthol exists as one pure stereoisomer, nearly always the (1R, ... Menthol also shares anaesthetic properties similar to propofol by modulating the same sites of the GABAA receptor. Menthol is ... "Menthol". Drug Information Portal. U.S. National Library of Medicine. Ryoji Noyori Nobel lecture (2001) A review of menthol ...
... menthol content by weight. Lower-tar menthol cigarettes may have menthol levels up to 2%, in order to keep menthol delivery ... A menthol cigarette is a cigarette infused with the compound menthol which imparts a "minty" flavor to the smoke. Menthol also ... Menthol cigarettes are just as hard to quit and are just as harmful as regular cigarettes. Menthol cigarettes have been banned ... Menthol may be derived from distilled corn mint oil, or produced synthetically. While trace amounts of menthol may be added to ...
In enzymology, a (−)-menthol monooxygenase (EC 1.14.13.46) is an enzyme that catalyzes the chemical reaction (−)-menthol + ... This enzyme is also called l-menthol monooxygenase. Use of (−)-menthol monooxygenase has been explored by several companies ... The systematic name of this enzyme class is (−)-menthol,NADPH:oxygen oxidoreductase (8-hydroxylating). ... menthol, NADPH, H+, and O2, whereas its 3 products are p-menthane-3,8-diol, NADP+, and H2O. This enzyme belongs to the family ...
A (−)-menthol dehydrogenase (EC 1.1.1.207) is an enzyme that catalyzes the chemical reaction (−)-menthol + NADP+ ⇌ {\ ... Kjonaas R, Martinkus-Taylor C, Croteau R (May 1982). "Metabolism of Monoterpenes: Conversion of l-Menthone to l-Menthol and d- ... Thus, the two substrates of this enzyme are (−)-menthol and NADP+, whereas its 3 products are (−)-menthone, NADPH, and H+. This ... The systematic name of this enzyme class is (−)-menthol:NADP+ oxidoreductase. This enzyme is also called monoterpenoid ...
Menthol - A Cool Place -Page 1 (Articles with short description, Short description is different from Wikidata, Chemical data ... Baker MSDS (l-form) Fisher MSDS (DL or racemic form) Fisher MSDS (l-form) Ambix MSDS Menthol Eucalyptus ointment This box: view ... This page provides supplementary chemical data on Menthol. The handling of this chemical may incur notable safety precautions. ...
... is a 1994 EP by Guided by Voices. The song Matter Eater Lad is based on the superhero ... www.allmusic.com/album/clown-prince-of-the-menthol-trailer-ep-mw0000927549 "GBVDB - Guided By Voices Database". www.gbvdb.com. ... a 2022 compilation collecting many of these tracks Clown Prince of the Menthol Trailer,http:// ...
Davis EM, Ringer KL, McConkey M, Croteay R (2005). "Enzyme Menthol deghydrogenase". Matthijs HC, Coughlan SJ, Hind G (September ...
"Hotel Menthol musical". Cervinus Teatrum. Retrieved 2020-07-25. Hungária Zene.hu Discogs (CS1 Hungarian-language sources (hu), ... The 1981 album Hotel Menthol was another substantial hit. In 1982 the band played to 150,000 people at Népstadion in Budapest. ... Koncert a marson (1970) Hungária (1971) Beatles Laz (1978) Rock 'n' Roll Party (1980) Hotel Menthol (1981) Arena (1983) Finale ... titled Hotel Menthol, debuted in 1998 and was performed more than 200 times. ...
"Djarum Forte Menthol". CiggiesWorld. Retrieved 2022-02-17. "Djarum Super". CiggiesWorld. Retrieved 2022-02-17. "Djarum Super ...
"Cooler Than Menthol". Retrieved 2008-06-14. v t e (Chemical articles with multiple compound IDs, Multiple chemicals in an ... While the cooling strength of 3-(l-menthoxy)propane-1,2-diol is accepted as being about 20-25% that of menthol, it is also ... Menthoxypropanediol (also known as Cooling agent 10 [tradename of Takasago]), is a synthetic derivative of menthol. ... 2-diol shows a cool feeling 2.0 to 2.5 times stronger than that of l-menthol". It is used in various cosmetic chemical ...
Halls contain menthol, which acts as local anaesthetic and "creates a cooling sensation". It also acts as a cough suppressant. ... "Halls Cough Drops (Menthol)". Iodine, Medication information that really helps. Retrieved 25 April 2016. "HALLS MENTHO-LYPTUS ( ...
"Pianissimo Pêche Menthol One". Chen1923.blogspot.nl. 17 August 2008. Retrieved 1 February 2018. v t e (Articles with short ... "Pianissimo Pêche Menthol One". Chen1923.blogspot.nl. 17 August 2008. "PIANISSIMO - Okcig.com". Archived from the original on ... other variants like Petil and Franc were added and other JT Menthol brands were made into Pianissimo. Like Virginia S made by ...
"Tobacco makers fight menthol rules". Associated Press. 18 March 2011. Archived from the original on 27 April 2012. Retrieved 27 ... In March 2011, the tobacco industry released a report to the FDA in response to the TPSAC decision claiming menthol cigarettes ... Wilson, Duff (18 March 2011). "Advisory Panel Urges F.D.A. to Re-examine Menthol in Cigarettes". New York Times. Retrieved 27 ... On March 18, 2011 the panel concluded that removing menthol cigarettes from the market would benefit public health in the ...
In addition, mints can desensitize a region through the activation of TRPM8 receptors (the 'cold'/menthol receptor). The key ... Galeotti N, Di Cesare Mannelli L, Mazzanti G, Bartolini A, Ghelardini C (April 2002). "Menthol: a natural analgesic compound". ... biased agonist Erinacine E Menthol RB-64 - G protein biased agonist with a bias factor of 96; β-arrestin antagonist Salvinorin ... the naturally-occurring compound menthol is a weak KOR agonist owing to its antinociceptive, or pain blocking, effects in rats ...
"HORIZON LINES/BEL-AIR MENTHOL , LACMA Collections". collections.lacma.org. Retrieved 2023-08-05. Desmarais, Ilene Segalove: Why ... Gifts/I Love You/Bel Air Menthol (1975), and If You Live Near Hollywood, You Can't Help But Look Like Some 8x10 Glossy (1976). ...
The active ingredient is menthol and it also contains cetylated and esterified fatty acids. A before/after human study with no ... "Celadrin joint and muscle pain relieving- menthol cream". DailyMed. U.S. National Library of Medicine. Retrieved 2020-07-28. ... May 2005). "A cetylated fatty acid topical cream with menthol reduces pain and improves functional performance in individuals ... Factors Group of Nutritional Products (January 2013). "Prescribing monograph for Celadrin (menthol)". DailyMed. U.S. National ...
In most essential oils, it is a minor compound; it was first synthesized by oxidation of menthol in 1881 before it was found in ... On menthol or peppermint camphor". Journal of the Chemical Society, Transactions. 39: 77-83. doi:10.1039/CT8813900077. John ... It is structurally related to menthol, which has a secondary alcohol in place of the carbonyl. Menthone is used in flavoring, ... It was then synthesized by heating menthol with chromic acid, and its structure was later confirmed by synthesizing it from 2- ...
Gaubius isolated menthol in 1771. He was elected a Fellow of the Royal Society in 1764. One of his best known works was ...
Menthol - Adds sweet smell 3. Borneol - for smelling, relieves dizziness; for fainting, relieves pain and ache 4. Paraffin - ...
Menthol activates cold-sensitive TRPM8 receptors in the skin and mucosal tissues, and is the primary source of the cooling ... R. Eccles (1994). "Menthol and Related Cooling Compounds". J. Pharm. Pharmacol. 46 (8): 618-630. doi:10.1111/j.2042-7158.1994. ... M. × piperita and M. haplocalyx are both recognized as plant sources of menthol and menthone, and are among the oldest herbs ... Peppermint has a high menthol content. The essential oil also contains menthone and carboxyl esters, particularly menthyl ...
... excluding menthol); removed descriptions including "light," "mild," and "low-tar" from cigarette packs; and made larger the ...
In the same year, with the bans of menthol cigarettes in Nova Scotia in June 2015 and Alberta in September 2015, Global Tobacco ... In 2015, the Canadian Cancer Society warned that the use of so-called "click" cigarettes (which contain a capsule of menthol in ... Benham, Barbara (20 July 2016). "Menthol-Like Cigarettes Still Sold in Canada Despite Ban". Johns Hopkins Bloomberg School of ... Canadian Classics Original Canadian Classics Silver Canadian Classics White Canadian Classics Crush (menthol capsule) Canadian ...
Non-menthol throat lozenges generally use either zinc gluconate glycine or pectin as an oral demulcent. Several brands of ... However, one study found that excessive use of menthol cough drops can prolong coughs rather than relieve them. Candies to ... Other varieties such as Halls contain menthol, peppermint oil and/or spearmint as their active ingredient(s). Honey lozenges ... "Menthol Cough Drops: Cause for Concern?". Journal of the American Board of Family Medicine. 31 (2): 183-191. doi:10.3122/jabfm. ...
Measurable levels of eucalyptol and pulegone were found in the menthol-flavored varieties for all manufacturers. Menthol ... Interestingly, menthol was found at low concentrations in 40% of the tobacco-flavored nonmenthol products tested. Other flavor ... Menthol flavorings could also contain diacetyl. Diacetyl and acetyl propionyl are associated with bronchiolitis obliterans. A ... The four most commonly found flavor additives were vanillin, ethyl maltol, ethyl vanillin and menthol. They are carcinogenic or ...
The active ingredient of Original Strength Gold Bond Powder is Menthol. Inactive ingredients include talc and zinc oxide. The ... "Gold Bond Original Strength- menthol powder". DailyMed. National Institutes of Health. January 15, 2016. Archived from the ...
Menthol Pulegone BSBI List 2007 (xls). Botanical Society of Britain and Ireland. Archived from the original (xls) on 2015-06-26 ...
Menthol appeals to younger or beginning smokers largely because the menthol masks the harshness and discomfort of inhaling ... Trying menthols increases smoking initiation among youth and young adults, and menthols users face greater addiction and ... Where these demographics overlap, menthol use is especially high: most female LGBT smokers use menthols, as do 80 percent of ... excluding menthol. Canada banned menthol cigarettes in 2017. Preliminary research in Ontario Province indicates that this ban ...
"Débile menthol" was the first single released from the album on 26 April 2006. "Débile menthol - Single by Elisa Tovati". ...
Kaplan, Sheila (March 22, 2021). "Menthol Cigarettes Kill Many Black People. A Ban May Finally Be Near". New York Times. ...
"EU agrees ban on menthol cigarettes". RTÉ.ie. 21 June 2013. Archived from the original on 21 February 2014. Retrieved 6 ...
The main form of menthol occurring in nature is (−)-menthol, which is assigned the (1R,2S,5R) configuration. Menthol has local ... Menthol also acts as a weak κ-opioid receptor agonist. Natural menthol exists as one pure stereoisomer, nearly always the (1R, ... Menthol also shares anaesthetic properties similar to propofol by modulating the same sites of the GABAA receptor. Menthol is ... "Menthol". Drug Information Portal. U.S. National Library of Medicine. Ryoji Noyori Nobel lecture (2001) A review of menthol ...
Prohibiting sales of menthol and other tobacco products.. *Raising the price of menthol and other tobacco products and ... Learn about menthol and its relationship to tobacco product use and nicotine dependence among young people, how menthol ... Menthol Tobacco Productsplus icon*Menthol Tobacco Products are a Public Health Problem ... For example, after laws prohibiting the sale of menthol cigarettes were implemented in Canada, adults who smoked menthol ...
About 80 percent of black smokers prefer menthol cigarettes compared with 22 percent of white smokers. The civil rights group ... Food and Drug Administration is debating a ban on menthol cigarettes as their slightly minty taste can cover up tobaccos ... Should Menthol Cigarettes Be Banned? The U.S. Food and Drug Administration is debating a ban on menthol cigarettes as their ... And if 80 percent of smokers who are African-American use menthol products, to ban those products and to leave the non-menthol ...
This article discusses menthol poisoning from swallowing pure menthol. ... Menthol is used to add peppermint flavor to candy and other products. It is also used in certain skin lotions and ointments. ... Pure menthol is not easy to get. The menthol found in many over-the-counter products is usually watered down and mixed with ... This article discusses menthol poisoning from swallowing pure menthol.. This article is for information only. DO NOT use it to ...
Survey cookies are set by a third-party service provided by Qualtrics. These cookies are required in order for our feedback functionality to work. The survey cookies collect information about the page you are providing feedback from. When you save your survey cookies choice below, a cookie will be saved on your device to remember your choice. These cookies are set as session cookies and will be deleted once you close this browsing session.. We welcome your feedback and you can help us to continue to improve our website by turning survey cookies on.. ...
CHERRY COUGH DROP- menthol lozenge BestCo Inc.. Disclaimer: Most OTC drugs are not reviewed and approved by FDA, however they ...
Menthol not only gives smokers a "more pleasant" feeling in their mouths and throats, but also keeps tobacco smoke - with its ... The fact that menthol is added without the products label informing customers that it makes them more addictive is an ... Menthol additives, in fact, induce young people to start smoking, experts say. She tried smoking-cessation courses and holding ... The Florida case inspired Hausner to launch the first menthol-cigarette lawsuit in the world. ...
The FDA estimates that eliminating menthol products would reduce smoking rates by 15% within 40 years. ... The FDA said menthol interacts with nicotine in the brain to enhance nicotines addictive effects. The combination of menthols ... Menthol accounts for more than a third of cigarettes sold in the U.S, and the mint flavor is overwhelmingly favored by Black ... Menthol is the only cigarette flavor that was not banned under the 2009 law that gave the FDA authority over tobacco products. ...
After finding that a ban on menthol cigarettes in Canada was linked to a large increase in the number of smokers who quit, ... Menthol smokers who had quit smoking before the menthol ban were also significantly less likely than non-menthol smokers who ... The researchers found that menthol smokers were much more likely than non-menthol smokers to try to quit after the menthol ban ... and that daily menthol smokers were nearly two times more likely than daily non-menthol smokers to quit after the menthol ban ...
... and individuals reporting a greater frequency of mental distress are more likely to smoke menthol versus nonmenthol cigarettes ... Menthol cigarette smoking and health, Florida 2007 BRFSS Am J Health Behav. 2011 Jan-Feb;35(1):3-14. doi: 10.5993/ajhb.35.1.1. ... Objective: To examine associations between menthol cigarette smoking and nicotine dependence, quit attempts, and physical and ... Results: In multivariate analyses, menthol cigarette smoking was associated with women, African American and Hispanic race/ ...
... and menthol topical is a combination product that is applied to the skin. . When applied to the chest, inhaling the vapors of ... camphor, eucalyptus, and menthol topical camphor, eucalyptus, and menthol topical. Pronunciation: KAM for, ue ka LIP tus, and ... How should I use camphor, eucalyptus, and menthol topical? How should I use camphor, eucalyptus, and menthol topical?. Use ... What is camphor, eucalyptus, and menthol topical? What is camphor, eucalyptus, and menthol topical?. Camphor, eucalyptus, and ...
714-X is made by mixing chemicals with camphor, a natural substance that comes from the wood and bark of the camphor tree. 714-X is reported to help the ...
My colleagues and I have introduced two bills that would significantly restrict menthol and flavored e-cigarettes in New York. ... Menthol smokers also become more addicted; they have a lower rate of quitting. Sadly, but not surprisingly, more than half of ... In addition to the menthol loophole, we also now have a new front in the war against flavored tobacco: e-cigarettes. It seems I ... My grandfather was a menthol smoker-as are many people of color. Eighty-five percent of Black adult smokers and 64 percent of ...
Menthol has been the last allowable flavor in cigarettes, and the FDA says marginalized communities are far more likely to use ... Tobacco products with menthol can also be more addictive and harder to quit by enhancing the effects of nicotine." ... "Banning menthol - the last allowable flavor - in cigarettes and banning all flavors in cigars will help save lives, ... "The ban by the FDA is long overdue to protect the health of African Americans and to reduce the deleterious impact of menthol ...
"Menthol cools the harshness of any tobacco product," Barcelo said. "If its less harsh, doesnt burn their throat, has great ... Under a tobacco and menthol standard, nearly 39% of the participants said they would quit. ... Most youth would quit vaping if flavors, including menthol, were not available, research shows. ... flavor refers to e-cigarette flavors with a fruit base characterizing flavor with a cooling additive such as menthol or a ...
Helwit Menthol Slim Nicotine Pouches kaufen im Northerner ✔ schnelle Lieferung ✔ Gratis Versand ✔ seit 1998 für Sie da ☛ ... Die Infos zu Helwit Menthol. Die Helwit Menthol Nicotine Pouches verfügen über einen langanhaltenden Geschmack nach Minze. ... Die Nikotinstärke der Helwit Menthol Snus. Die Helwit Menthol Nikotinbeutel sind mit 12 mg/g Nikotin angereichert. Damit ... Die Helwit Menthol Snus aus Schweden bringen den sommerlichen Geschmack von frischer Minze. Mit einem Nikotingehalt 12 mg/g ...
More information on the menthol capsules by the German Cancer Research Centre is available here ... of Consumer Protection and Food Safety has rejected an application by a tobacco company to sell cigarettes containing menthol ...
... such as the heat associated with capsaicin and the cold felt with menthol. The latter of these was influential in the discovery ... The menthol receptor TRPM8 is the principal detector of environmental cold.[Nature. 2007]. The menthol receptor TRPM8 is the ... TRPM8: The Cold and Menthol Receptor - TRP Ion Channel Function in Sensory Trans.... TRPM8: The Cold and Menthol Receptor - TRP ... potency of menthol in activating currents, and voltage dependence of membrane currents induced by either cold or menthol [2,3, ...
Menthol, typically found and used in cigarettes, may be banned by the end of this week. The Food and Drug Administration (FDA) ... The FDA Could Ban Menthol Cigarettes Following Petition And Lawsuit April 27, 2021 News 0 ... is working toward putting an end to menthol being used in cigarettes, as it would significantly prevent health issues related ...
Find more product information on Herbal Lozenge Menthol Cough Drop and shop online. ... Buy Discount Herbal Lozenge Menthol Cough Drop 15 lozenges, Zand at VitaSprings. ... Write a Review on this Herbal Lozenge Menthol Cough Drop product and share your experience or opinion with other customers.. ... Buy Herbal Lozenge Menthol Cough Drop from Zand at VitaSprings, and we guarantee you a safe, secure online shopping experience ...
An announcement that the FDA is working toward banning menthol cigarettes within the next year. The agency plans to issue ... FDA plans to ban menthol cigarettes, flavored cigars. This column reviews details on recent recalls, alerts, and approvals. ... including menthol) in cigars. The decision is based on the evidence establishing the addictiveness and harm of these products ... proposed product standards to ban menthol as a characterizing flavor in cigarettes and ban all characterizing flavors ( ...
Includes tracks, mixtapes, and bio information on Young Menthol Dez ... Young Menthol Dez artist profile on Coast 2 Coast Mixtapes. ... Videos By Young Menthol Dez. Mixtapes Featuring Young Menthol ...
Buy CHEAP Premium CIGARETTES online at the best tobacco store. 4Cigarettes.Net - Your Best Choice ...
Pack your pipe and savor the flavor of the good ol USA with this Cheyenne Menthol Pipe Tobacco 16oz 2-fer Deal! This smooth ... Ask a product specific question about Cheyenne Menthol Pipe Tobacco 16oz 2-Fer. ... blend of velvety Burley and tangy Virginia is finished with a pleasantly cool splash of menthol. ...
Alleviate your sore throat in seconds with these menthol flavor cough drops from MGC Health. Designed to suppress coughs and ...
Menthol in cigarette smoke activates the cold-receptor TRPM8 and mediates a ... Activation of the cold-receptor TRPM8 by low levels of menthol in tobacco products. Menthol in cigarette smoke activates the ... Activation of the cold-receptor TRPM8 by low levels of menthol in tobacco products. Meike Paschke, Anna Tkachenko, Katja ... The study has assessed the minimum menthol contents in cigarettes required for TRPM8 activation. A measurable activation of ...
Menthol has been the last allowable flavor in cigarettes, and the FDA says marginalized communities are far more likely to use ... Menthol cigarettes and other tobacco products at a store in San Francisco in 2018. U.S. health regulators announced a new ... Tobacco products with menthol can also be more addictive and harder to quit by enhancing the effects of nicotine." ... "Banning menthol - the last allowable flavor - in cigarettes and banning all flavors in cigars will help save lives, ...
How likely are you to recommend this product or service to a friend? ...
The menthol ban is likely to have a major impact on the health of Black Americans, who smoke menthols at much higher rates than ... Together, they found that 22.3 per cent of menthol smokers quit following the ban, compared to 15 per cent of non-menthol ... Fong and his ITC Project colleagues showed that banning menthol cigarettes made Canadian menthol smokers significantly more ... he led an evaluation of Canadas recent menthol cigarette ban that was cited by the FDA as it explored a U.S. menthol ban. ...
Wildfire legislation in House, menthol cigarette manufacturing to cease. This episode from May 5 goes over the implementation ... After that, listeners hear from Matthew Myers of the Campaign for Tobacco-Free Kids about the prohibition on menthol cigarettes ...
  • Federal law prohibits cigarettes to be marketed with characterizing flavors, except tobacco or menthol. (cdc.gov)
  • 3, 4, 5 Evidence from other countries supports the public health benefits of removing menthol cigarettes from the marketplace. (cdc.gov)
  • For example, after laws prohibiting the sale of menthol cigarettes were implemented in Canada, adults who smoked menthol cigarette reported high rates of quit attempts and quit successes. (cdc.gov)
  • 3,6 Adults who had smoked menthol cigarettes daily before the law went into effect and tried quitting smoking were more likely to report having quit cigarettes than adults who had smoked non-menthol cigarettes. (cdc.gov)
  • Should Menthol Cigarettes Be Banned? (npr.org)
  • The U.S. Food and Drug Administration is debating a ban on menthol cigarettes as their slightly minty taste can cover up tobacco's harshness. (npr.org)
  • About 80 percent of black smokers prefer menthol cigarettes compared with 22 percent of white smokers. (npr.org)
  • menthol cigarettes. (npr.org)
  • About 80 percent of black smokers prefer menthol cigarettes. (npr.org)
  • What is being described as the world's first class action lawsuit on behalf of people who developed lung cancer from smoking menthol cigarettes has been initiated by Israel's leading anti-tobacco attorney, Amos Hausner, The Jerusalem Post has learned. (jpost.com)
  • Research conducted by tobacco companies a decade or more ago to identify additives that increase tobacco addiction showed that menthol did the trick, and the companies made a special effort to market cigarettes with this additive. (jpost.com)
  • Foreign research has shown that African Americans become even more addicted to menthol cigarettes than whites do. (jpost.com)
  • She started with non-menthol cigarettes and then switched to Montana - smoking up to two packs a day without realizing that menthol caused them to be more addictive and made it very difficult to quit. (jpost.com)
  • She had long thought that menthol cigarettes were "less dangerous" than ordinary ones because they did not taste so bad. (jpost.com)
  • FILE - Menthol cigarettes and other tobacco products are displayed at a store in San Francisco on May 17, 2018. (abc15.com)
  • The U.S. government is set to release its long-awaited plan to ban menthol cigarettes and flavored cigars. (abc15.com)
  • Menthol accounts for more than a third of cigarettes sold in the U.S, and the mint flavor is overwhelmingly favored by Black smokers and young people. (abc15.com)
  • The combination of menthol's flavor, sensory effects and interaction with nicotine in the brain increases the likelihood that youth who start using menthol cigarettes will progress to regular use, the FDA said. (abc15.com)
  • Could banning menthol cigarettes be key to lowering smoking rates overall? (upi.com)
  • New research suggests it's possible, after finding that a ban on menthol cigarettes in Canada was linked to a large increase in the number of smokers who quit. (upi.com)
  • The impact of the menthol ban in Canada suggests that a similar ban in the United States would have even greater benefits since menthol cigarettes are much more popular among Americans, the researchers said. (upi.com)
  • From our findings, we estimate that banning menthol cigarettes in the U.S. would lead an additional 923,000 smokers to quit, including 230,000 African American smokers," said researcher Geoffrey Fong. (upi.com)
  • In the United States, there's growing momentum in Congress to enact a national ban on menthol cigarettes, while similar measures are being considered at the state and local levels. (upi.com)
  • At the same time, the U.S. Food and Drug Administration faces a court order to respond to a citizen's petition to ban menthol cigarettes by April 29, according to The New York Times. (upi.com)
  • Menthol, the most common flavoring for cigarettes in many countries, reduces the harshness of cigarette smoke. (upi.com)
  • Canada was one of the first countries to ban menthol cigarettes. (upi.com)
  • Scientific reviews conducted by U.S. health experts and the World Health Organization concluded that banning menthol cigarettes would have significant public health benefits. (upi.com)
  • In the United States, those benefits might be greatest among Black Americans because menthol cigarettes are used by 85% of Black smokers, which is more than 2.8 times higher than among white smokers. (upi.com)
  • Our study demonstrates the substantial benefits of banning menthol cigarettes," Fong said in a university press release. (upi.com)
  • Women, racial/ethnic minorities, and individuals reporting a greater frequency of mental distress are more likely to smoke menthol versus nonmenthol cigarettes. (nih.gov)
  • Sadly, but not surprisingly, more than half of youth smokers use menthol cigarettes. (citylimits.org)
  • In addition to the menthol loophole, we also now have a new front in the war against flavored tobacco: e-cigarettes. (citylimits.org)
  • The U.S. Food and Drug Administration says it is moving to ban menthol cigarettes and flavored cigars, based on the evidence of the addictiveness and harm of the products. (kcbx.org)
  • Tobacco companies have long targeted African Americans with advertising for menthol cigarettes. (kcbx.org)
  • Banning menthol - the last allowable flavor - in cigarettes and banning all flavors in cigars will help save lives, particularly among those disproportionately affected by these deadly products," acting FDA Commissioner Dr. Janet Woodcock said in a statement Thursday. (kcbx.org)
  • The agency said it will focus on keeping the products off the market, as opposed to targeting individual use: "The FDA cannot and will not enforce against individual consumer possession or use of menthol cigarettes or any tobacco product. (kcbx.org)
  • While the FDA made a similar announcement to prohibit menthol cigarettes in 2018 during the Trump administration, a ban did not come to pass. (kcbx.org)
  • The FDA said about 18.6 million people in the U.S. currently smoke menthol cigarettes, but their use is uneven: Almost 85% of Black smokers use menthol cigarettes, compared with 30% of white smokers. (kcbx.org)
  • It pointed to an FDA finding that if menthol cigarettes had been removed from the marketplace in 2010, "by 2020, roughly 17,000 premature deaths would have been avoided and about 2.3 million people would not have started smoking. (kcbx.org)
  • It cited a study suggesting that banning menthol cigarettes in the U.S. "would lead an additional 923,000 smokers to quit, including 230,000 African Americans in the first 13 to 17 months after a ban goes into effect. (kcbx.org)
  • The African American Tobacco Control Leadership Council has long pushed to ban menthol cigarettes. (kcbx.org)
  • OCTOBER 2012 -The Federal Office of Consumer Protection and Food Safety has rejected an application by a tobacco company to sell cigarettes containing menthol capsules in the filter, on the grounds of public health. (who.int)
  • Menthol, typically found and used in cigarettes, may be banned by the end of this week. (balleralert.com)
  • The Food and Drug Administration (FDA) is working toward putting an end to menthol being used in cigarettes, as it would significantly prevent health issues related to menthol in the Black community. (balleralert.com)
  • The study has assessed the minimum menthol contents in cigarettes required for TRPM8 activation. (bund.de)
  • U.S. health regulators announced a new effort Thursday to ban menthol cigarettes. (wmot.org)
  • When the U.S. Food and Drug Administration (FDA) announced in April 2022 that it was moving forward with a ban on menthol cigarettes , FDA Commissioner Dr. Robert Califf said the ban would help smokers quit, stop young people from starting smoking, and save lives. (oicr.on.ca)
  • Canada became one of the first countries to ban menthol cigarettes when all provinces introduced bans between 2015 and 2018, and then became the first country where a menthol ban has been evaluated on whether it leads smokers to quit. (oicr.on.ca)
  • In their initial analysis published in April 2021 , Dr. Fong and his ITC Project colleagues showed that banning menthol cigarettes made Canadian menthol smokers significantly more likely to quit than those who smoked non-menthol cigarettes. (oicr.on.ca)
  • Developing educational initiatives that describe targeted tobacco industry marketing tactics and warn about the risks of tobacco product use, including menthol products. (cdc.gov)
  • 1 As of March 2023, over 170 U.S. communities have implemented laws prohibiting the sale of menthol and other flavored tobacco products. (cdc.gov)
  • 2 Massachusetts became the first U.S. state to prohibit the sale of menthol and other flavored tobacco products. (cdc.gov)
  • And the one flavor they did not touch was menthol. (npr.org)
  • Menthol is used to add peppermint flavor to candy and other products. (medlineplus.gov)
  • Menthol is the only cigarette flavor that was not banned under the 2009 law that gave the FDA authority over tobacco products. (abc15.com)
  • But the most common flavor, menthol, was exempted. (citylimits.org)
  • Adolescents and young adults using flavors with cooling additives, such as "fruit ice," reported higher odds of discontinuing use under a tobacco-only product standard compared with users who preferred menthol flavor only, said Tackett. (daytondailynews.com)
  • The "fruit ice" flavor refers to e-cigarette flavors with a fruit base characterizing flavor with a cooling additive such as menthol or a synthetic cooling agent. (daytondailynews.com)
  • Pack your pipe and savor the flavor of the good ol' USA with this Cheyenne Menthol Pipe Tobacco 16oz 2-fer Deal! (thompsoncigar.com)
  • Alleviate your sore throat in seconds with these menthol flavor cough drops from MGC Health. (biglots.com)
  • VitaSprings does not imply any medical claims from the customer reviews on this Herbal Lozenge Menthol Cough Drop product on this website. (vitasprings.com)
  • Write a Review on this Herbal Lozenge Menthol Cough Drop product and share your experience or opinion with other customers. (vitasprings.com)
  • Buy Herbal Lozenge Menthol Cough Drop from Zand at VitaSprings, and we guarantee you a safe, secure online shopping experience! (vitasprings.com)
  • To assess the ban's impact, Fong and his colleagues surveyed nearly 1,100 non-menthol and 138 menthol smokers in 2016, before the ban and in 2018, after the ban. (upi.com)
  • What is the most important information I should know about camphor, eucalyptus, and menthol topical? (cigna.com)
  • Camphor, eucalyptus, and menthol topical is a combination product that is applied to the skin. (cigna.com)
  • Camphor, eucalyptus, and menthol topical may also be used for purposes not listed in this medication guide. (cigna.com)
  • What should I discuss with my healthcare provider before using camphor, eucalyptus, and menthol topical? (cigna.com)
  • How should I use camphor, eucalyptus, and menthol topical? (cigna.com)
  • Since camphor, eucalyptus, and menthol is used when needed, it does not have a dosing schedule. (cigna.com)
  • What should I avoid while using camphor, eucalyptus, and menthol topical? (cigna.com)
  • What are the possible side effects of camphor, eucalyptus, and menthol topical? (cigna.com)
  • The FDA said that "menthol masks unpleasant flavors and harshness of tobacco products, making them easier to start using. (kcbx.org)
  • citation needed] Menthol occurs naturally in peppermint oil (along with a little menthone, the ester menthyl acetate and other compounds), obtained from Mentha × piperita (peppermint). (wikipedia.org)
  • Natural menthol is obtained by freezing peppermint oil. (wikipedia.org)
  • The aim of the present study was to assess whether the gastric peristalsis -suppressing effect is dose -dependently induced by L- menthol , the major constituent of peppermint oil, and to determine the recommended dose of an L- menthol preparation. (bvsalud.org)
  • Learn about menthol and its relationship to tobacco product use and nicotine dependence among young people, how menthol products are disproportionately marketed to specific groups of people, and the risks of using tobacco products. (cdc.gov)
  • Learn about menthol and its relationship to tobacco use, nicotine dependence, and reduced cessation success. (cdc.gov)
  • To examine associations between menthol cigarette smoking and nicotine dependence, quit attempts, and physical and mental health. (nih.gov)
  • Menthol also lowers blood pressure and antagonizes vasoconstriction through TRPM8 activation. (wikipedia.org)
  • Menthol in cigarette smoke activates the cold-receptor TRPM8 and mediates a "cooling effect" that is independent from its mint-like aroma. (bund.de)
  • A measurable activation of TRPM8 is expected when the content of menthol exceeds 50 μg per cigarette. (bund.de)
  • Menthol can be harmful in large amounts. (medlineplus.gov)
  • But the American Medical Association said the evidence is clear on the harmful impacts of menthols and called the FDA's decision long overdue. (kcbx.org)
  • The ban "did not lead to a high level of illicit menthol cigarette purchasing, which has been a concern by regulators considering a menthol ban," said Fong, who added that "fewer than 10% of menthol smokers reported still smoking a menthol brand after the ban. (upi.com)
  • The enormous success of the Canadian menthol ban makes it even clearer now that the U.S. should finally ban menthol, which the tobacco industry has used for decades to attract new smokers and to keep many of them as customers, especially among the African American community," Fong said. (upi.com)
  • Applying that 7.3 per cent difference to the more than 18 million menthol smokers in the U.S. gave Dr. Fong and colleagues their 1.3 million estimate. (oicr.on.ca)
  • Our study is the most complete evaluation of Canada's menthol cigarette ban," Dr. Fong said. (oicr.on.ca)
  • Some studies show that menthol acts as a GABAA receptor positive allosteric modulator and increases GABAergic transmission in PAG neurons. (wikipedia.org)
  • Most cold-sensitive neurons are also sensitive to the ubiquitous cooling compound menthol, a cyclic terpene alcohol found in mint leaves [ 10 ]. (nih.gov)
  • Ingredients of candies and chewing gums that may cause irritant or allergic contact stomatitis include flavoring agents (rare) (cinnamon compounds, menthol) and propolis, a strong sensitizer often used in the oral cavity because of its antiseptic properties. (medscape.com)
  • It is well known that moderate concentrations of menthol induce a pleasant cool sensation, such as that felt when using menthol-containing products such as candy and vapo-rubs. (nih.gov)
  • The ban by the FDA is long overdue to protect the health of African Americans and to reduce the deleterious impact of menthol smoking and tobacco use overall on America's health," he said. (kcbx.org)
  • Smoking kills about 45,000 Canadians every year, and public health authorities including the World Health Organization have long advocated for banning menthols, which have added flavouring and are popular among young smokers, women and some minority groups. (oicr.on.ca)
  • As Chief Principal Investigator of the International Tobacco Control Policy Evaluation Project (ITC Project) at the University of Waterloo, he led an evaluation of Canada's recent menthol cigarette ban that was cited by the FDA as it explored a U.S. menthol ban. (oicr.on.ca)
  • Licensing retailers who sell any types of tobacco products, to better understand who is selling menthol and other tobacco products and to aid with equitable implementation and enforcement of tobacco control policies. (cdc.gov)
  • Prohibiting sales of menthol and other tobacco products. (cdc.gov)
  • Raising the price of menthol and other tobacco products and prohibiting price discounts. (cdc.gov)
  • Curbing the advertising and marketing of menthol and other tobacco products to young people. (cdc.gov)
  • Ensuring that all people who use tobacco products have access to evidence-based quitting resources , including counseling and medication , to help them successfully quit, and tailoring of cessation messages to better reach people who use menthol products. (cdc.gov)
  • Implement school prevention and cessation programs that are free from tobacco industry influence, that include education about menthol products, and that can be tailored to groups that the tobacco industry targets with menthol marketing. (cdc.gov)
  • Learn about how menthol products are disproportionately marketed to and used by specific groups of people. (cdc.gov)
  • Other products may also contain menthol. (medlineplus.gov)
  • The menthol found in many over-the-counter products is usually watered down and mixed with other ingredients. (medlineplus.gov)
  • The suit further argued that Dubek was guilty of "misleading consumers" by not warning that menthol additives make their products more addictive. (jpost.com)
  • The FDA estimates that eliminating menthol products would reduce smoking rates by 15% within 40 years. (abc15.com)
  • Tobacco products with menthol can also be more addictive and harder to quit by enhancing the effects of nicotine. (kcbx.org)
  • Menthol smokers who had quit smoking before the menthol ban were also significantly less likely than non-menthol smokers who had quit smoking to have started smoking again, according to the study published online this week in the journal Tobacco Control. (upi.com)
  • Japanese menthol also contains a small percentage of the 1-epimer neomenthol. (wikipedia.org)
  • African American adults have the highest percentage of menthol cigarette use compared with other racial and ethnic groups, according to the Centers for Disease Control and Prevention. (kcbx.org)
  • Menthol is widely used in dental care as a topical antibacterial agent, effective against several types of streptococci and lactobacilli. (wikipedia.org)
  • Menthol has local anesthetic and counterirritant qualities, and it is widely used to relieve minor throat irritation. (wikipedia.org)
  • However, when present at higher doses menthol can be noxious, causing burning, irritation, and pain [ 10-12 ]. (nih.gov)
  • Although reported to be human irritants, menthol (50%), and p-xylenol (10%) were negative for both irritation and sensitization at the highest concentrations tested. (cdc.gov)
  • Total world production of menthol in 1998 was 12,000 tonnes of which 2,500 tonnes was synthetic. (wikipedia.org)
  • In 2005, the annual production of synthetic menthol was almost double. (wikipedia.org)
  • Indeed, the researchers hypothesized that menthol exerted its actions on "an enzyme" that was involved in the activation of these nerves [ 13 ]. (nih.gov)
  • The fact that menthol is added without the product's label informing customers that it makes them more addictive is an additional violation, the lawsuit contends. (jpost.com)
  • The FDA said menthol interacts with nicotine in the brain to enhance nicotine's addictive effects. (abc15.com)
  • Ask a product specific question about Cheyenne Menthol Pipe Tobacco 16oz 2-Fer . (thompsoncigar.com)
  • Menthol is an organic compound, more specifically a monoterpenoid, made synthetically or obtained from the oils of corn mint, peppermint, or other mints. (wikipedia.org)
  • Mentha arvensis (wild mint) is the primary species of mint used to make natural menthol crystals and natural menthol flakes[citation needed]. (wikipedia.org)
  • Adverse events in the L- menthol dose groups occurred with similar frequencies in the placebo group. (bvsalud.org)
  • Together, they found that 22.3 per cent of menthol smokers quit following the ban, compared to 15 per cent of non-menthol smokers. (oicr.on.ca)
  • Menthol not only gives smokers a "more pleasant" feeling in their mouths and throats, but also keeps tobacco smoke - with its many toxins - inside the lungs longer, making it even more dangerous. (jpost.com)
  • In seminal studies conducted by Hensel and Zotterman in the 1950s, menthol elicited its "cool" sensation by increasing the threshold temperature for activation of cold receptors [ 13 ]. (nih.gov)
  • This smooth blend of velvety Burley and tangy Virginia is finished with a pleasantly cool splash of menthol. (thompsoncigar.com)
  • Stimulation of upper airway cold receptors on the trigeminal nerve (TGN) with TGN agonists such as menthol or cool air to the face/nose has been hypothesized to reduce breathlessness by decreasing IND. (lu.se)
  • Otherwise, TGN stimulation with menthol or cool air to the face/note had no effect on measures of IND in humans. (lu.se)
  • The menthol ban is likely to have a major impact on the health of Black Americans, who smoke menthols at much higher rates than other Americans and who have been targeted by aggressive menthol tobacco marketing. (oicr.on.ca)
  • DAVE CHAPPELLE: Why do black people love menthols so much? (npr.org)
  • Eighty-five percent of Black adult smokers and 64 percent of Latinos who smoke buy menthols. (citylimits.org)
  • Menthol also shares anaesthetic properties similar to propofol by modulating the same sites of the GABAA receptor. (wikipedia.org)
  • So the question is: Should the FDA - they have an advisory panel out there - look carefully at menthol, and should they include menthol in the flavorings that are banned? (npr.org)
  • Three weeks later, the FDA announced that it would develop a rule to ban menthol , citing the ITC study. (oicr.on.ca)
  • This newest study builds on the ITC Project's previous work by combining ITC data across 7 provinces with data from another project that also evaluated the impact of the menthol ban only in Ontario. (oicr.on.ca)
  • Multicenter phase II randomized study evaluating dose-response of antiperistaltic effect of L-menthol sprayed onto the gastric mucosa for upper gastrointestinal endoscopy. (bvsalud.org)
  • In this phase II, multicenter, double-blind, dose -response study, 131 eligible patients were randomly assigned to receive 20 mL of 0.4% L- menthol (n = 32), 0.8% L- menthol (n = 35), 1.6% L- menthol (n = 30), or placebo (n = 34). (bvsalud.org)
  • Studies show that tobacco companies undertake predatory tactics to hook blacks and Latinos on menthol. (citylimits.org)
  • Further Phase III studies are needed to establish the superiority of 0.8% L- menthol over placebo. (bvsalud.org)
  • Buy MERIT ULTRA MENTHOL 100 online for USA and Canada customers! (4cigarettes.net)
  • Menthols, like the Newport brand, have a slightly minty taste that can cover up tobacco's harshness. (npr.org)
  • That is the most popular brand of menthols in the country, but they declined to participate at all. (npr.org)
  • And I think that if there were no menthol flavoring, it would have a dramatic impact in keeping kids from starting to smoke. (npr.org)
  • The main form of menthol occurring in nature is (−)-menthol, which is assigned the (1R,2S,5R) configuration. (wikipedia.org)