A relatively common neoplasm of the CENTRAL NERVOUS SYSTEM that arises from arachnoidal cells. The majority are well differentiated vascular tumors which grow slowly and have a low potential to be invasive, although malignant subtypes occur. Meningiomas have a predilection to arise from the parasagittal region, cerebral convexity, sphenoidal ridge, olfactory groove, and SPINAL CANAL. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2056-7)
Benign and malignant neoplastic processes that arise from or secondarily involve the meningeal coverings of the brain and spinal cord.
A delicate membrane enveloping the brain and spinal cord. It lies between the PIA MATER and the DURA MATER. It is separated from the pia mater by the subarachnoid cavity which is filled with CEREBROSPINAL FLUID.
Neoplasms of the bony part of the skull.
Increase in the mass of bone per unit volume.
Neoplasms of the base of the skull specifically, differentiated from neoplasms of unspecified sites or bones of the skull (SKULL NEOPLASMS).
Junction between the cerebellum and the pons.
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
The outermost of the three MENINGES, a fibrous membrane of connective tissue that covers the brain and the spinal cord.
Tumor suppressor genes located on the long arm of human chromosome 22. Mutation or loss of these genes causes NEUROFIBROMATOSIS 2.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
A benign SCHWANNOMA of the eighth cranial nerve (VESTIBULOCOCHLEAR NERVE), mostly arising from the vestibular branch (VESTIBULAR NERVE) during the fifth or sixth decade of life. Clinical manifestations include HEARING LOSS; HEADACHE; VERTIGO; TINNITUS; and FACIAL PAIN. Bilateral acoustic neuromas are associated with NEUROFIBROMATOSIS 2. (From Adams et al., Principles of Neurology, 6th ed, p673)
Benign and malignant neoplasms that arise from the optic nerve or its sheath. OPTIC NERVE GLIOMA is the most common histologic type. Optic nerve neoplasms tend to cause unilateral visual loss and an afferent pupillary defect and may spread via neural pathways to the brain.
A tumor composed of spindle cells with a rich vascular network, which apparently arises from pericytes, cells of smooth muscle origin that lie around small vessels. Benign and malignant hemangiopericytomas exist, and the rarity of these lesions has led to considerable confusion in distinguishing between benign and malignant variants. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1364)
Surgery performed on the nervous system or its parts.
Tumors or cancer of any part of the hearing and equilibrium system of the body (the EXTERNAL EAR, the MIDDLE EAR, and the INNER EAR).
An autosomal dominant disorder characterized by a high incidence of bilateral acoustic neuromas as well as schwannomas (NEURILEMMOMA) of other cranial and peripheral nerves, and other benign intracranial tumors including meningiomas, ependymomas, spinal neurofibromas, and gliomas. The disease has been linked to mutations of the NF2 gene (GENES, NEUROFIBROMATOSIS 2) on chromosome 22 (22q12) and usually presents clinically in the first or second decade of life.
Any operation on the cranium or incision into the cranium. (Dorland, 28th ed)
Neoplasms located in the brain ventricles, including the two lateral, the third, and the fourth ventricle. Ventricular tumors may be primary (e.g., CHOROID PLEXUS NEOPLASMS and GLIOMA, SUBEPENDYMAL), metastasize from distant organs, or occur as extensions of locally invasive tumors from adjacent brain structures.
A neoplasm that arises from SCHWANN CELLS of the cranial, peripheral, and autonomic nerves. Clinically, these tumors may present as a cranial neuropathy, abdominal or soft tissue mass, intracranial lesion, or with spinal cord compression. Histologically, these tumors are encapsulated, highly vascular, and composed of a homogenous pattern of biphasic fusiform-shaped cells that may have a palisaded appearance. (From DeVita Jr et al., Cancer: Principles and Practice of Oncology, 5th ed, pp964-5)
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
The three membranes that cover the BRAIN and the SPINAL CORD. They are the dura mater, the arachnoid, and the pia mater.
The large hole at the base of the skull through which the SPINAL CORD passes.
A specific pair of GROUP G CHROMOSOMES of the human chromosome classification.
A membrane protein homologous to the ERM (Ezrin-Radixin-Moesin) family of cytoskeleton-associated proteins which regulate physical properties of membranes. Alterations in neurofibromin 2 are the cause of NEUROFIBROMATOSIS 2.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
A extremely rare bone tumor characterized by abundant collagen formation and a fibrous stroma, without evidence of mitosis or pleomorphism. It appears on x-rays as an osteolytic lesion with well-defined margins and must be differentiated from primary fibrosarcoma of bone. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1441)
A neoplasm derived from blood vessels, characterized by numerous prominent endothelial cells that occur singly, in aggregates, and as the lining of congeries of vascular tubes or channels. Hemangioendotheliomas are relatively rare and are of intermediate malignancy (between benign hemangiomas and conventional angiosarcomas). They affect men and women about equally and rarely develop in childhood. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1866)
An irregular unpaired bone situated at the SKULL BASE and wedged between the frontal, temporal, and occipital bones (FRONTAL BONE; TEMPORAL BONE; OCCIPITAL BONE). Sphenoid bone consists of a median body and three pairs of processes resembling a bat with spread wings. The body is hollowed out in its inferior to form two large cavities (SPHENOID SINUS).
Conditions which affect the structure or function of the pupil of the eye, including disorders of innervation to the pupillary constrictor or dilator muscles, and disorders of pupillary reflexes.
The compartment containing the anterior extremities and half the inferior surface of the temporal lobes (TEMPORAL LOBE) of the cerebral hemispheres. Lying posterior and inferior to the anterior cranial fossa (CRANIAL FOSSA, ANTERIOR), it is formed by part of the TEMPORAL BONE and SPHENOID BONE. It is separated from the posterior cranial fossa (CRANIAL FOSSA, POSTERIOR) by crests formed by the superior borders of the petrous parts of the temporal bones.
Inflammation of the NASAL MUCOSA in the SPHENOID SINUS. Isolated sphenoid sinusitis is uncommon. It usually occurs in conjunction with other paranasal sinusitis.
The largest country in North America, comprising 10 provinces and three territories. Its capital is Ottawa.
Benign and malignant neoplasms which occur within the substance of the spinal cord (intramedullary neoplasms) or in the space between the dura and spinal cord (intradural extramedullary neoplasms). The majority of intramedullary spinal tumors are primary CNS neoplasms including ASTROCYTOMA; EPENDYMOMA; and LIPOMA. Intramedullary neoplasms are often associated with SYRINGOMYELIA. The most frequent histologic types of intradural-extramedullary tumors are MENINGIOMA and NEUROFIBROMA.
A voluntary organization concerned with the prevention and treatment of cancer through education and research.
A cylindrical column of tissue that lies within the vertebral canal. It is composed of WHITE MATTER and GRAY MATTER.
Deviations from the average values for a specific age and sex in any or all of the following: height, weight, skeletal proportions, osseous development, or maturation of features. Included here are both acceleration and retardation of growth.
The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.
The group in which legal authority is vested for the control of health-related institutions and organizations.
Materials used as reference points for imaging studies.
The practice of sending a patient to another program or practitioner for services or advice which the referring source is not prepared to provide.
A subspecialty of internal medicine concerned with the study of neoplasms.
A subspecialty of medical oncology and radiology concerned with the radiotherapy of cancer.
A radiological stereotactic technique developed for cutting or destroying tissue by high doses of radiation in place of surgical incisions. It was originally developed for neurosurgery on structures in the brain and its use gradually spread to radiation surgery on extracranial structures as well. The usual rigid needles or probes of stereotactic surgery are replaced with beams of ionizing radiation directed toward a target so as to achieve local tissue destruction.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Elements of limited time intervals, contributing to particular results or situations.
A syndrome characterized by recurrent episodes of excruciating pain lasting several seconds or longer in the sensory distribution of the TRIGEMINAL NERVE. Pain may be initiated by stimulation of trigger points on the face, lips, or gums or by movement of facial muscles or chewing. Associated conditions include MULTIPLE SCLEROSIS, vascular anomalies, ANEURYSMS, and neoplasms. (Adams et al., Principles of Neurology, 6th ed, p187)
A bony prominence situated on the upper surface of the body of the sphenoid bone. It houses the PITUITARY GLAND.
Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.

SPARC: a potential diagnostic marker of invasive meningiomas. (1/1193)

SPARC, a secreted, extracellular matrix-associated protein implicated in the modulation of cell adhesion and migration, was evaluated as a marker for invasive meningiomas. Although the majority of meningiomas are clinically and morphologically benign, approximately 10% progress into atypical and malignant tumors, according to the standard criteria. However, a subset of meningiomas presents as histomorphologically benign tumors (WHO grade I), but they are clinically invasive. It has been suggested that these tumors should be classified as malignant, and that the patients may require adjuvant therapy and closer follow up. Unfortunately, a significant number of these tumors may not be recognized because the surgical specimen used to assess the grade of a tumor lacks the infiltrative interface with the brain, which is currently necessary to determine its invasive character. Therefore, a marker of heightened invasiveness would greatly facilitate the identification of this subset of patients. In this study, the immunohistochemical expression of SPARC in benign, noninvasive primary meningiomas was compared with its expression in invasive, aggressive, primary and recurrent meningiomas. SPARC was not expressed in the 9 benign, noninvasive tumors, but was highly expressed in the 20 invasive tumors, regardless of the grade. The findings suggest that SPARC is a potential diagnostic marker of invasive meningiomas and is capable of distinguishing the histomorphologically benign noninvasive from the histomorphologically benign but invasive meningiomas, in the absence of the infiltrative interface.  (+info)

Hemangioblastoma mimicking tentorial meningioma: preoperative embolization of the meningeal arterial blood supply--case report. (2/1193)

A 72-year-old male presented with a primary hemangioblastoma of the posterior fossa with unusual dural attachment and meningeal arterial blood supply from the external carotid artery and marginal tentorial artery. Preoperative embolization facilitated complete resection of the tumor with no resultant neurological deficit. Hemangioblastoma must be included in the differential diagnosis of tumors with dural involvement. Preoperative embolization is very useful in such tumors.  (+info)

Cerebral veins: comparative study of CT venography with intraarterial digital subtraction angiography. (3/1193)

BACKGROUND AND PURPOSE: Our objective was to compare the reliability of CT venography with intraarterial digital subtraction angiography (DSA) in imaging cerebral venous anatomy and pathology. METHODS: In 25 consecutive patients, 426 venous structures were determined as present, partially present, or absent by three observers evaluating CT multiplanar reformatted (MPR) and maximum intensity projection (MIP) images. These results were compared with the results from intraarterial DSA and, in a second step, with the results of an intraobserver consensus. In addition, pathologic conditions were described. RESULTS: Using DSA as the standard of reference, MPR images had an overall sensitivity of 95% (specificity, 19%) and MIP images a sensitivity of 80% (specificity, 44%) in depicting the cerebral venous anatomy. On the basis of an intraobserver consensus including DSA, MPR, and MIP images (415 vessels present), the sensitivity/specificity was 95%/91% for MPR, 90%/100% for DSA, and 79%/91% for MIP images. MPR images were superior to DSA images in showing the cavernous sinus, the inferior sagittal sinus, and the basal vein of Rosenthal. Venous occlusive diseases were correctly recognized on both MPR and MIP images. Only DSA images provided reliable information of invasion of a sinus by an adjacent meningioma. CONCLUSION: CT venography proved to be a reliable method to depict the cerebral venous structures. MPR images were superior to MIP images.  (+info)

A new technique of surface anatomy MR scanning of the brain: its application to scalp incision planning. (4/1193)

BACKGROUND AND PURPOSE: Surface anatomy scanning (SAS) is an established technique for demonstrating the brain's surface. We describe our experience in applying SAS with superposition of MR venograms to preoperative scalp incision planning. METHODS: In 16 patients, scalp incision planning was done by placing a water-filled plastic tube at the intended incision site when we performed SAS using half-Fourier single-shot fast spin-echo sequences. Two-dimensional phase-contrast MR angiograms were obtained to demonstrate the cortical veins and then superimposed upon the SAS images. The added images were compared with surgical findings using a four-point grading scale (0 to 3, poor to excellent). RESULTS: In each case, neurosurgeons could easily reach the lesion. Surgical findings correlated well with MR angiogram-added SAS images, with an average score of 2.56. CONCLUSION: Our simple technique is a useful means of preoperatively determining brain surface anatomy and can be used to plan a scalp incision site.  (+info)

In vivo hydrogen-1 magnetic resonance spectroscopy study of human intracranial tumors. (5/1193)

OBJECTIVE: To investigate the metabolic changes, pathological state and histological types of intracranial tumors with hydrogen-1 magnetic resonance spectroscopy (H-1 MRS). METHODS: Thirteen patients with intracranial tumors were studied with localized proton magnetic resonance spectroscopy (H-1MRS), in vivo. All spectra were obtained with a 2.0 T whole body MR imaging system. RESULTS: All the spectra of these tumors exhibited high ratios of choline (Cho)/creatine (Cr) and Cho/N-acetyl aspartate (NAA), and histologically different tumors showed obvious variations in the metabolite ratios. Significant differences of Cho/Cr ratio were found between meningiomas and astrocytomas by statistical evaluation. The spectra obtained after operation were remarkably different from those before operation. CONCLUSION: H-1 MRS can serve as a non-invasive clinical test for therapeutic and prognostic uses for intracranial tumors.  (+info)

NF2 gene mutations and allelic status of 1p, 14q and 22q in sporadic meningiomas. (6/1193)

Formation of meningiomas and their progression to malignancy may be a multi-step process, implying accumulation of genetic mutations at specific loci. To determine the relationship between early NF2 gene inactivation and the molecular mechanisms that may contribute to meningioma tumor progression, we have performed deletion mapping analysis at chromosomes 1, 14 and 22 in a series of 81 sporadic meningiomas (54 grade I (typical), 25 grade II (atypical) and two grade III (anaplastic)), which were also studied for NF2 gene mutations. Single-strand conformational polymorphism analysis was used to identify 11 mutations in five of the eight exons of the NF2 gene studied. All 11 tumors displayed loss of heterozygosity (LOH) for chromosome 22 markers; this anomaly was also detected in 33 additional tumors. Twenty-nine and 23 cases were characterized by LOH at 1p and 14q, respectively, mostly corresponding to aggressive tumors that also generally displayed LOH 22. All three alterations were detected in association in seven grade II and two grade III meningiomas, corroborating the hypothesis that the formation of aggressive meningiomas follows a multi-step tumor progression model.  (+info)

Clinical features and outcomes in patients with non-acoustic cerebellopontine angle tumours. (7/1193)

OBJECTIVES: Non-acoustic tumours of the cerebellopontine angle differ from vestibular schwannomas in their prevalence, clinical features, operative management, and surgical outcome. These features were studied in patients presenting to the regional neuro-otological unit. METHODS: A retrospective analysis of clinical notes identified 42 patients with non-acoustic tumours of the cerebellopontine angle. Data were extracted regarding presenting clinical features, histopathological data after surgical resection, surgical morbidity and mortality, and clinical outcome (mean 32 months follow up). RESULTS: The study group comprised 25 meningiomas (60%), 12 epidermoid cysts/cholesteatomata (28%), and five other tumours. In patients with meningiomas, symptoms differed considerably from patients presenting with vestibular schwannomas. Cerebellar signs were present in 52% and hearing loss in only 68%. Twenty per cent of patients had hydrocephalus at the time of diagnosis. After surgical resection, normal facial nerve function was preserved in 75% of cases. In the epidermoid group, fifth, seventh, and eighth nerve deficits were present in 42%, 33%, and 66% respectively. There were no new postoperative facial palsies. There were two recurrences (17%) requiring reoperation. Overall, there were two perioperative deaths from pneumonia and meningitis. CONCLUSIONS: Patients with non-acoustic lesions of the cerebellopontine angle often present with different symptoms and signs from those found in patients with schwannomas. Hearing loss is less prevalent and cerebellar signs and facial paresis are more common as presenting features. Hydrocephalus is often present in patients presenting with cerebellopontine angle meningiomas. Non-acoustic tumours can usually be resected with facial nerve preservation.  (+info)

Role of p53 gene mutation in tumor aggressiveness of intracranial meningiomas. (8/1193)

The mutations that occur in the p53 tumor suppressor gene have been studied in various human malignant tumors. However, little is known about this gene in meningiomas. To investigate the relationship and frequency of p53 gene mutations, the p53 polymerase chain reaction-single stranded conformational polymorphism (PCR-SSCP) and immunohistochemical study were performed on the 41 intracranial meningiomas (21 benign, 11 atypical, and 9 malignant). The higher the p53 protein expression rate, the poorer the histologic grade (9.5%, 72.7%, and 88.9% in benign, atypical and malignant meningioma, respectively) (p=0.000). The p53 protein expression rate was higher in recurrent meningioma (71.4%) than in nonrecurrent meningioma (10.5%) (p=0.002). PCR-SSCP method was performed in positive p53 protein immunoreactivity cases. p53 gene mutation rate was higher in the atypical (62.5%) and malignant (25%) meningiomas than in the benign meningioma (0%) (p=0.232). Also, the rate was higher in recurrent menigioma (20%) than in nonrecurrent meningioma (0%) (o=0.495). Among five to eight exons of the p53 gene, the mutation was observed on exon 7 more frequently. In conclusion, p53 immunoreactivity and p53 gene mutation are closely correlated with histologic grade and histologic atypia of intracranial meningiomas. p53 gene mutation would be considered as a useful marker to detect the progression of intracranial meningiomas.  (+info)

Extracranial meningiomas are classified according to Hoye et al. [4]. Primary extracranial meningioma and secondary extracranial meningioma can be classified according to the presence or absence of an intracranial meningioma. Primary extracranial meningiomas are composed of two types: a tumor originating from arachnoid cells remaining in the nerve sheaths and a tumor occurring ectopically without connection to the cranium. Secondary extracranial meningiomas are classified as intracranial tumors directly escaping from the cranium and extracranial meningioma that has metastasized from an intracranial meningioma [6]. According to this classification, our case is classified as an ectopic primary extracranial meningioma.. Intradural meningioma is known to be associated with radiation, virus, head trauma, smoking, nitrate, and high cholesterol levels, but the cause of primary extracranial meningioma is not yet clear. Possible hypotheses are as follows: (1) migration of arachnoid cells along the ...
meningioma; Meningiomas, Multiple; Meningiomatosis; Benign Meningioma; Malignant Meningioma. On-line free medical diagnosis assistant. Ranked list of possible diseases from either several symptoms or a full patient history. A similarity measure between symptoms and diseases is provided.
A meningioma is a type of brain tumor thats said to be to second most common type of brain tumor occurring in humans today. A meningioma brain tumor primarily develops in the meninges, the thin layers of tissue surrounding the spinal cord and the brain. In most cases, these brain tumors can grow in size and spread, although its difficult to determine the tumors growth rate. Upon growth, these tumors put pressure on surrounding brain tissue.. Meningiomas can be classified into three grades, as set by the World Health Organization. Grade I meningiomas are classified as benign, Grade II meningiomas are identified as atypical, while Grade III meningiomas are considered anaplastic. Meningiomas are usually benign, but Grade III meningiomas are malignant. The average survival rate for Grade III meningiomas, without relapse, is currently at about three years.. There are some factors that contribute to the development of brain tumors in the meninges. Excessive exposure to ionizing radiation or x-rays ...
Introduction: Meningiomas are predominantly benign tumors, which arise from the arachnoids cap cells. The development mechanism is unknown but they may result from an adverse effect of cranial irradiation and trauma. Antigen KI-67 also known as Ki-67 or MKI67 is a protein that in humans is encoded by the MKI67 gene (antigen identified by monoclonal antibody Ki-67). The antigen KI-67 is a nuclear protein that is associated with and may be necessary for cellular proliferation. Inactivation of antigen KI-67 leads to inhibition of ribosomal RNA synthesis. Ki-67 is an excellent marker to determine the growth fraction of a given cell population, the fraction of Ki-67-positive tumor cells (the Ki-67 labeling index) is often correlated with the clinical course of cancer. Materials and Methods: This is a cross-sectional study that had been performed at the National Center for Neurological Sciences during February 2011 to December 2013. The study included samples from intracranial meningioma patients ...
This report presents magnetic resonance imaging (MRI) findings of a breast carcinoma metastasis in an intracranial meningioma with correlated pathological findings. MRI showed multiple foci of intense enhancement with hypointense surrounding areas. The described foci appeared to be metastatic disease from the patients known breast carcinoma. In addition, this is the first study reported in the literature to have investigated the expression of a possibly common carcinogenic molecule in breast carcinoma metastatic to a coexisting meningioma: overexpressed c-myc oncogene was found both in the breast carcinoma compartment and in the meningioma component of the tumor. ...
TY - JOUR. T1 - Single-fraction radiosurgery of benign intracranial meningiomas. AU - Pollock, Bruce E.. AU - Stafford, Scott L.. AU - Link, Michael J.. AU - Brown, Paul D.. AU - Garces, Yolanda I.. AU - Foote, Robert L.. PY - 2012/9/1. Y1 - 2012/9/1. N2 - BACKGROUND:: Stereotactic radiosurgery (SRS) of benign intracranial meningiomas is an accepted management option for well-selected patients. OBJECTIVE:: To analyze patients who had single-fraction SRS for benign intracranial meningiomas to determine factors associated with tumor control and neurologic complications. METHODS:: Retrospective review was performed of 416 patients (304 women/112 men) who had single-fraction SRS for imaging defined (n = 252) or confirmed World Health Organization grade I (n = 164) meningiomas from 1990 to 2008. Excluded were patients with radiation-induced tumors, multiple meningiomas, neurofibromatosis type 2, and previous or concurrent radiotherapy. The majority of tumors (n = 337; 81%) involved the cranial base ...
TY - JOUR. T1 - Rhabdoid meningioma. T2 - Report of two cases. AU - Reddy, Ch Karunakar. AU - Divakar Rao, A.. AU - Ballal, Chandra K.. AU - Chakraborti, Shrijeet. PY - 2015/2/1. Y1 - 2015/2/1. N2 - Rhabdoid meningioma is an uncommon anaplastic variant of meningioma. We describe the clinicoradiological and histomorphological features of two such cases of meningioma, with a brief review of literature. One case in a 9-year-old girl, presented initially as an atypical meningioma in the right fronto-parietal region, which on recurrence 18 months later, evolved into a rhabdoid meningioma. The second case in a 33-year-old male was located in the right parieto-occipital region.. AB - Rhabdoid meningioma is an uncommon anaplastic variant of meningioma. We describe the clinicoradiological and histomorphological features of two such cases of meningioma, with a brief review of literature. One case in a 9-year-old girl, presented initially as an atypical meningioma in the right fronto-parietal region, which ...
MalaCards based summary : Benign Meningioma, also known as meningioma, benign, is related to secretory meningioma and spinal meningioma. An important gene associated with Benign Meningioma is NF2 (Neurofibromin 2), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. The drugs Hydroxyurea and Gefitinib have been mentioned in the context of this disorder. Affiliated tissues include brain, lung and bone, and related phenotypes are Decreased viability and Decreased viability ...
Coexistence of pituitary adenoma, intracranial meningioma and cerebral aneurysm has never been described. We report on a patient with GH-secreting pituitary macroadenoma associated with a right...
Hallinan JT, Hegde AN, Lim WE. Dilemmas and diagnostic difficulties in meningioma. Clin Radiol. 2013 Aug;68[8]:837-44. http://dx.doi.org/10.1016/j.crad.2013.03.007 PMid:23623578 Fathi AR, Roelcke U. Meningioma. Curr Neurol Neurosci Rep. 2013;13(4):337. http://dx.doi.org/10.1007/s11910-013-0337-4 PMid:23463172 Osborn AG, Salzman KL, Barkovich AJ. Meningioma and atypical and malignant meningioma. In: Osborn AG, editor. Diagnostic imaging: brain. 2nd ed. Salt lake city: Lippincott Williams & Wilkins/Amirys, 2009: p. 72-81. de Almeida JP, Petteys RJ, Sciubba DM, Gallia GL, Brem H. Regression of intracranial meningioma following intratumoral hemorrhage. J Clin Neurosci. 2009;16:1246 9. http://dx.doi.org/10.1016/j.jocn.2008.11.017 PMid:19560362 Goncalves AM, Page P, Domigo V, Meder JF, Oppenheim C. Abrupt regression of a meningioma after discontinuation of cyproterone treatment. AJNR Am J Neuroradiol. 2010;31:1504 5. http://dx.doi.org/10.3174/ajnr.A1978 PMid:20053802 Shimizu J, Matsumoto M, Yamazaki ...
Intracranial meningioma and glioma collision tumors are relatively uncommon and are even more rarely located within the ventricles. Here, we report a case of a patient with an intraventricular meningioma and astrocytoma collision tumor. A 39-year-old man previously underwent excision of an astrocytoma in the triangle area of the lateral ventricle and exhibited good post-surgery recovery. The astrocytoma recurred in situ six years after the surgery, and the case was complicated by a malignant meningioma. The patient recovered well after surgery to treat the recurrence and was administered radiotherapy after discharge. In addition to reporting on this case, we conducted a literature review of collision tumors; based on this review, we propose several hypotheses regarding the formation of collision tumors. We conclude that a possible cause of the collision tumor formation between the intracranial meningioma and the astrocytoma was the recurrence of an astrocytoma-induced malignancy of the arachnoid cells
Request for free sample report: https://www.delveinsight.com/sample-request/meningioma-market. Table of Contents:. 1. Key Insights. 2. Executive Summary of Meningioma. 3. Competitive Intelligence Analysis for Meningioma. 4. Meningioma : Market Overview at a Glance. 4.1. Meningioma Total Market Share (%) Distribution in 2017. 4.2. Meningioma Total Market Share (%) Distribution in 2030. 5. Meningioma : Disease Background and Overview. 5.1. Introduction. 5.2. Sign and Symptoms 5.3. Pathophysiology 5.4. Risk Factors 5.5. Diagnosis 6. Patient Journey. 7. Meningioma Epidemiology and Patient Population. 7.1. Epidemiology Key Findings. 7.2. Assumptions and Rationale: 7MM. 7.3. Epidemiology Scenario: 7MM. 7.3.1. Meningioma Epidemiology Scenario in the 7MM (2017-2030). 7.4. United States Epidemiology. 7.4.1. Meningioma Epidemiology Scenario in the United States (2017-2030). 7.5. EU-5 Country-wise Epidemiology. 7.5.1. Germany Epidemiology. 7.5.1.1. Meningioma Epidemiology Scenario in Germany ...
Dr. Nader Sanai, an Associate Professor of Neurological Surgery at the Barrow Neurological Institute in Phoenix, Arizona, has received a $15,000 grant to fund his latest research project, A Phase 0/II Study of LEE011 in Recurrent Atypical and Malignant Meningioma Patients.. This proposal represents the first Phase 0 atypical and malignant meningioma trial in history. Dr. Sanai and his team will determine the plasma exposure and brain accumulation of LEE011 following 5-day dosing in patients with recurrent atypical and malignant meningiomas; will evaluate select PD biomarkers corresponding to CDK4/6 inhibition, including Rb phosphorylation, cells in M-phase of cell cycle (PH3), and FoxM1 downregulation and explore the safety and efficacy of LEE011 in recurrent atypical and malignant meningioma with demonstrated pharmacokinetic and pharmacodynamic effects.. Dr. Sanai shares, What drives me forward is the opportunity to discover things that others in humankind have never seen, as we as find ...
A case of malignant meningioma which has grown rapidly after gross total removal and metastasized to thoracic spines after second operation is reported. We recommend that early spinal magnetic resonance image should be performed in patient with spinal symptoms and signs after the treatment of intracranial meningioma and intensive treatment combined with operation and radiosurgery should be performed for the reduction of growth rate in the recurred malignant meningoma. ...
Twenty four meningiomas (17 benign and seven atypical were reacted with a panel of monoclonal antibodies to macrophages, lymphocytes, and HLA DR antigens. All the tumours contained macrophages but these cells were more numerous in the atypical meningiomas. Lymphocytes, almost exclusively of the CD8 subtype, were also present in 70% of benign meningiomas and in all atypical meningiomas and were more abundant in the latter. B lymphocytes were present in minimal numbers in three atypical meningiomas and in one benign meningioma. CD4 positive T lymphocytes were present in small numbers in one benign meningioma and in moderate numbers in one atypical meningioma. HLA DR antigen expression on tumour cells was present in about 60% of both tumour groups. The numbers of macrophages and T and CD8 lymphocytes in meningiomas seem to be related to atypical histological features, and the presence of these cells raises questions about host immune response and the relation of this to prognosis.. ...
Intraventricular Malignant Meningioma - Malignant meningioma· Intraventricle· Frontal horn· Third ventricle· Surgical approach.J Korean Neurosurg Soc 34 : 379-381;KISEP380 J Korean Neurosurg Soc 34Intraventricular Malignant Meningiomaand was removed a piecemealfashion using biopsy forceps
Meningiomas are mostly benign brain tumours, with a potential for becoming atypical or malignant. On the basis of comprehensive genomic, transcriptomic and epigenomic analyses, we compared benign meningiomas to atypical ones. Here, we show that the majority of primary (de novo) atypical meningiomas display loss of NF2, which co-occurs either with genomic instability or recurrent SMARCB1 mutations. These tumours harbour increased H3K27me3 signal and a hypermethylated phenotype, mainly occupying the polycomb repressive complex 2 (PRC2) binding sites in human embryonic stem cells, thereby phenocopying a more primitive cellular state. Consistent with this observation, atypical meningiomas exhibit upregulation of EZH2, the catalytic subunit of the PRC2 complex, as well as the E2F2 and FOXM1 transcriptional networks. Importantly, these primary atypical meningiomas do not harbour TERT promoter mutations, which have been reported in atypical tumours that progressed from benign ones. Our results ...
Meningiomas account for approximately 30% of all primary central nervous system tumors and are found in half of neurofibromatosis type 2 patients often causing significant morbidity. Although most meningiomas are benign, 10% are classified as atypical or anaplastic, displaying aggressive clinical behavior. Biallelic inactivation of the neurofibromatosis 2 (NF2) tumor suppressor is associated with meningioma formation in all NF2 patients and 60% of sporadic meningiomas. Deletion of the p16INK4a/p14ARF locus is found in both benign and malignant meningiomas, while mutation of the p53 tumor suppressor gene is uncommon. Previously, we inactivated Nf2 in homozygous conditional knockout mice by adenoviral Cre delivery and showed that Nf2 loss in arachnoid cells is rate-limiting for meningioma formation. Here, we report that additional nullizygosity for p16Ink4a increases the frequency of meningioma and meningothelial proliferation in these mice without modifying the tumor grade. In addition, by using ...
Introduction Forkhead Box M1 (FOXM1) and aryl hydrocarbon receptor (AHR) signaling pathway participate in meningioma development, but their correlation was inadequately studied. The study is aimed to uncover their functions and correlation in malignant meningioma. Material and methods...
Background: Meningioma is one of the primary brain tumors that most often occurs at the age of 60-70 years, originating from arachnoid cap cells. FGF-2 as a growth factor is a potent stimulator of endothelial proliferation which is very important in the process of angiogenesis. FGF-2 levels in meningiomas have been assessed using the ELISA and qrPCR methods in many previous studies using blood serum in malignant cases with normal brain tissue as control. This study used tissue samples of meningioma tumors in which most cases of meningioma are benign. Objective: To assess the association between immunohistochemical expressions of FGF-2 and histopathology grade among meningioma patients. Material and Method: Formalin-fixed paraffin-embedded tissue blocks of 32 meningioma patients were immunohistochemically studied for FGF-2 expression. The basic characteristics of the samples were obtained through medical records or pathology archieves. The association between FGF-2 expression and grade were ...
TY - JOUR. T1 - Preoperative Embolization of Intracranial Meningiomas. AU - Yoshida, Kazunari. AU - Toya, Shigeo. AU - Takamiya, Yoshiaki. AU - Murakami, Hideki. AU - Kawase, Takeshi. AU - Shiga, Hayao. PY - 1985. Y1 - 1985. N2 - The method and results for preoperative embolization are described in 36 cases with intracranial meningiomas. Embolization materials were injccted through a transfemoral catheter, selectively placed in the external carotid artery. Chopped gelfoam served as embolization material in 29 patients and ivalon particles were used in 7 patients. In 19 out of 36 cases the feeding arteries arose only from the external carotid artery system and were completely occluded (complete embolization) except in 3 cases. The remaining 17 cases also had feeders of the tumor capsule or at the site of the insertion arising from the internal carotid artery system (partial embolization). Thirty-three cases were followed by computed tomography (CT) between embolization and operation. Contrast ...
Meningioma Mommas is asking for help to fund an exciting new project by the team of University of Colorado researchers we have previously funded. Please help us help the researchers find better treatment options for meningioma patients by donating here or via our own Donate page.. From the researchers:. PROJECT SUMMARY. Meningiomas are a common brain tumor, considered to be the most prevalent primary brain tumor in the central nervous system. In spite of their burden, no FDA approved pharmacotherapies exist for the treatment of these tumors. Through our work with Meningioma Mommas, we have created a high throughput drug screen that allows us to directly measure the sensitivity of individual tumors to hundreds of FDA approved compounds. This approach has identified several possible treatments that have the ability to treat meningiomas broadly by targeting epigenetic processes. Many of the drugs in this class can cross the blood brain barrier making these ideal candidates for further studies. ...
Meningioma is the most common extra-axial benign brain tumor. It is more common in females than males. Meningioma has both typical and atypical features. The diagnosis of typical meningioma is easier than atypical. Major differential diagnoses fo...
TY - JOUR. T1 - Metastatic meningioma in fine-needle aspiration (FNA) of the lung. T2 - Cytomorphologic finding. AU - Baisden, Blaire L.. AU - Hamper, Ulrike M.. AU - Ali, Syed Z.. PY - 1999/5. Y1 - 1999/5. N2 - Pulmonary metastasis of intracranial meningioma is rare. We present the cytomorphologic features of such a tumor in a 71 yr-old woman who was found to have multiple lung nodules 13 years following the resection of an atypical intracranial meningioma. Cytomorphologic features were quite distinct and included hypercellularity with large syncytial groups of monomorphic cells with epithelioid morphologic features, often in perivascular arrangements. Occasional intranuclear cytoplasmic inclusions as well as binucleated cells with wispy cytoplasmic extensions were also noted. Immunoperoxidase studies showed focal positivity for epithelial membrane antigen. The differential diagnosis includes primary or metastatic adenocarcinoma, malignant mesothelioma, and melanoma.. AB - Pulmonary metastasis ...
Anaplastic meningiomas (also known as malignant meningiomas) are uncommon, accounting for only ~1% of all meningiomas 1. Along with rhabdoid meningioma and papillary meningioma are considered WHO grade III tumors and demonstrate aggressive local ...
Meningiomas, which invade intracranial bone structures and the adjacent connective tissue, are frequently unresectable because of their aggressive and recalcitrant growth behavior. They have a high recurrence rate, and in approximately 10% of these tumors there is an increased risk of malignancy. Significant morbidity and mortality rates associated with recurrent meningiomas demand nonsurgical approaches. To date, adjuvant hormonal treatment has not proven beneficial. The anticancer drug hydroxyurea was therefore tested for its potential use in the treatment of meningiomas.. Early-passaged cell cultures were established from 20 different meningiomas. The addition of 5 X 10−4 and 10−3 M hydroxyurea over a period of 5 to 9 days resulted in a remarkable decrease in cell proliferation and even blocked tumor cell growth when compared with untreated cells. A significant arrest of meningioma cell growth in the S phase of the cell cycle was revealed on DNA flow cytometry.. Electron micrographs of ...
The aim of this work was to study the vascular endothelial growth factor A (VEGF-A) pathway and peritumoral brain edema (PTBE) through comparison of non-angiomatous and angiomatous meningiomas. Meningiomas are common intracranial tumors, which often have PTBE. VEGF-A is an integral part of PTBE formation and angiogenesis, and the capillary-rich angiomatous meningiomas are known for their PTBE. The VEGF-A receptor VEGFR-2 is responsible for the angiogenic effect of VEGF-A on endothelial cells, which is enhanced by the co-receptor neuropilin-1. Forty non-angiomatous, 22 angiomatous meningiomas, and 10 control tissue samples were collected for the study. Magnetic resonance images were available for 40 non-angiomatous and 10 angiomatous meningiomas. Tissue sections were immunostained for CD34, MIB-1, estrogen- and progesterone receptors. ELISA, chemiluminescence, and RT-qPCR were used for VEGF-A, VEGFR-2, and neuropilin-1 protein and mRNA quantification. Angiomatous meningiomas had larger PTBE (695 ...
BackgroundTo study the association between use of wireless phones and meningioma.MethodsWe performed a case-control study on brain tumour cases of both genders aged 18-75 years and diagnosed during 2007-2009. One population-based control matched on gender and age was used to each case. Here we report on meningioma cases including all available controls. Exposures were assessed by a questionnaire. Unconditional logistic regression analysis was performed.ResultsIn total 709 meningioma cases and 1,368 control subjects answered the questionnaire. Mobile phone use in total produced odds ratio (OR) = 1.0, 95% confidence interval (CI) = 0.7-1.4 and cordless phone use gave OR = 1.1, 95% CI = 0.8-1.5. The risk increased statistically significant per 100 h of cumulative use and highest OR was found in the fourth quartile (|2,376 hours) of cumulative use for all studied phone types. There was no statistically significant increased risk for ipsilateral mobile or cordless phone use, for meningioma in the temporal
Meningiomas are uncommonly associated with cysts and account for 1.6-10% of intracranial meningiomas 1) 2) 3) Those with more numerous smaller peripheral cysts are more frequent (8-23% of cases). They are over-represented in male patients and the paediatric population Clinical presentation Patients present clinically in the same way as patients with non-cystic meningiomas, with either symptoms related to increased intracranial pressure (ICP), focal neurology, or seizures. Pathology Various mechanisms have been proposed, and probably more than one is applicable depending on the location of the cysts: degeneration or necrosis direct secretion by meningioma reactive changes (peripheral arachnoid cysts) Classification Nauta et al. divided cystic meningiomas into four subtypes according to the location of the cyst with respect to the brain and meningioma type 1: intratumoral cyst(s), located centrally within the meningioma type 2: intratumoral cyst(s), situated peripherally within the meningioma but ...
A sphenoid wing meningioma is a benign brain tumor near the sphenoid bone. A meningioma is a benign brain tumor. It originates from the arachnoid (not the dura), the tissue covering the brain and spinal cord lying deep to the dura. Meningiomas are much more common in females, and are more common after 50 years of age. Of all cranial meningiomas, about 20% of them are in the sphenoid wing. In some cases, deletions involving chromosome 22 are involved. Sphenoid wing meningiomas are diagnosed by the combination of suggestive symptoms from the history and physical and neuroimaging by magnetic resonance imaging (MRI) or computer averaged tomography (CT). Tumors growing in the inner wing (clinoidal) most often cause direct damage to the optic nerve leading especially to a decrease in visual acuity, progressive loss of color vision, defects in the field of vision (especially cecocentral), and an afferent pupillary defect. If the tumor continues to grow and push on the optic nerve, all vision will be ...
Meningiomas are tumours of the membranes that cover the brain. Meningiomas are described as atypical when the tumor cells do not appear typical or normal. The standard treatment for patients with atypical meningioma is surgery to remove the tumour. Radiotherapy to kill any tumour cells left behind after surgery (post-operative radiotherapy) can increase the patient survival rate. The aim of this study is to find out whether a form of radiotherapy called carbon ion boost in combination with post-operative photon radiotherapy can improve the patient survival rate after 3 years ...
TY - JOUR. T1 - Fatal hemorrhagic infarction of posterior fossa meningioma during cardiopulmonary bypass. AU - Sun, Hai. AU - Ross, Donald (Don). PY - 2012/2. Y1 - 2012/2. N2 - Few publications address cardiac surgery in the presence of meningioma. Individual complications include transient visual loss from a suprasellar meningioma, hemiparesis after mitral valve replacement with recovery after resection, and non-fatal hemorrhage into a posterior fossa meningioma. The largest report of 16 patients with known meningiomas over 11 years suggested a benign course, with no new neurologic symptoms and no required resection of a meningioma over an average follow-up of 31 months. In 2 cases we report a presumed posterior fossa meningioma led to fatal outcome after cardiac surgery performed on bypass. Possible causes and future considerations are discussed.. AB - Few publications address cardiac surgery in the presence of meningioma. Individual complications include transient visual loss from a ...
TY - JOUR. T1 - Anatomic location is a risk factor for atypical and malignant meningiomas. AU - Kane, Ari J.. AU - Sughrue, Michael E.. AU - Rutkowski, Martin J.. AU - Shangari, Gopal. AU - Fang, Shanna. AU - McDermott, Michael W.. AU - Berger, Mitchel S.. AU - Parsa, Andrew T.. N1 - Copyright: Copyright 2011 Elsevier B.V., All rights reserved.. PY - 2011/3/15. Y1 - 2011/3/15. N2 - BACKGROUND: Grade II and III meningiomas have higher rates of tumor recurrence than grade I meningiomas after surgery and/or external irradiation. As the utility of noninvasive treatments for brain tumors increases, it is becoming increasingly important to assess the likelihood that a tumor is not benign before treatment initiation. Hence, the authors have reviewed a large series of their patients to determine risk factors for higher-grade pathology, with particular interest paid to tumor location. METHODS: The authors reviewed 378 patients presenting at their institution from 2000 to 2007 with histologically ...
Background: Concomitant dural arteriovenous fistulas (DAVFs) and meningiomas have been rarely described. DAVFs can be either continuous or at a distant location from the meningioma, with different pathophysiologic mechanisms involved in each situation.. Case Description: We report the case of a 74-year-old woman presenting with left-sided hemiparesis secondary to a large right convexity meningioma, associated with a noncontiguous Borden 3 DAVF. Both lesions were treated surgically in the same setting. The patient improved after surgery, and postoperative imaging showed complete resection of the meningioma and absence of recurrence of the fistula at 4 years.. Conclusion: To the best of our knowledge, this is the first case of concomitant surgical treatment of a meningioma and noncontiguous DAVF.. Keywords: Dural arteriovenous fistula, DAVF, Meningioma, Vascular malformations. ...
BACKGROUND: The etiologies of glioma and meningioma tumors are largely unknown. Although reproductive hormones are thought to influence the risk of these tumors, epidemiologic data are not supportive of this hypothesis; however, few cohort studies have published on this topic. We examined the relation between reproductive factors and the risk of glioma and meningioma among women in the European Prospective Investigation into Cancer and Nutrition (EPIC). METHODS: After a mean of 8.4 years of follow-up, 193 glioma and 194 meningioma cases were identified among 276,212 women. Information on reproductive factors and hormone use was collected at baseline. Cox proportional hazard regression was used to determine hazard ratios (HR) and 95% confidence intervals (95% CI). RESULTS: No associations were observed between glioma or meningioma risk and reproductive factors, including age at menarche, parity, age at first birth, menopausal status, and age at menopause. A higher risk of meningioma was observed ...
TY - JOUR. T1 - SINDROME DI WERNER E MENINGIOMA INTRACRANICO. AU - Borroni, G.. AU - Vignati, G.. AU - Zaccone, C.. AU - Brazzelli, V.. AU - Scappaticci, S.. AU - Cerimele, D.. AU - Rabbiosi, G.. PY - 1989. Y1 - 1989. N2 - A case of Werners Syndrome in a 47-year-old man, with typical features of pangeria associated with intracranial meningioma is described. A review of the literature showed that meningioma is the most frequent benign neoplasm in Werners Syndrome. Meningioma is a peculiar model of neoplasm, because of the frequency of cytogenetical aberrations concerning chromosome n. 22. Either chromosome n. 22 and other chromosomal alterations could be detected in peripheral blood lymphocytes of our patient. These findings suggest a correlation between chromosomal instability and the onset of neoplasms in Werners Syndrome. Furthermore, the possibility of detecting chromosome n. 22 aberrations in peripheral blood lymphocytes of Werners Syndrome patients could provide a clue to the presence ...
Primary extradural meningiomas are rare, accounting for less than 2% of all meningiomas; most cases involve the skull. A review of 169 cases was published by Lang et al.2 Only 3 cases of primary meningioma involving the mandible have been reported so far. The first case was by Landini and Kitano in 19923; another 2 cases were by Jones and Freedman in 2001.4 All patients, including ours, were women, and the radiographic presentation was a lytic lesion. Three cases of extracranial meningioma of the maxilla have been reported, excluding cases within the paranasal sinuses. A male patient presented with an oral lesion and a multilocular radiolucency on a periapical x-ray film.5 In 2 female patients, dental x-ray demonstrated a mixed radiolucent-radiopaque mass6 with ill-defined margins in 1 patient.7. To our knowledge, the appearance of mandibular meningioma in CT and MR imaging has not been previously reported.. The lesion in our patient appeared as a cystic lesion of the mandibular body on ...
MENINGIOMA. Meningiomas are extra-axial tumours and represent the most common tumour of the meninges. They are a non-glial neoplasm that originates from the arachnoid cap cells of the meninges. They are typically benign with a low recurrence rate but rarely can be malignant.. Typical meningiomas appear as dural based masses isointense to grey matter on both T1 and T2 weighted imaging, and demonstrate vivid contrast enhancement on both MRI and CT. There are, however, many variants some of which can vary dramatically in their imaging appearance. Epidemiology. Meningiomas are more common in women, with a ratio of 2:1 intracranially and 4:1 in the spine. Atypical and malignant meningiomas are slightly more common in males. They are uncommon in patients before the age of 40 and should raise suspicion of neurofibromatosis type 2(NF2) when found in young patients.. Grading. Generally follows the WHO classification for CNS tumours:. ...
2Hacettepe Üniversitesi Tıp Fakültesi Beyin Cerrahisi Anabilim Dalı, Ankara Meningiomas represent approximately 13-26% of primary intracranial tumours. Many small meningiomas have no symptoms during life and may be found incidentally at autopsy. Such incidental meningiomas are detected more frequently in recent years because of the advent of CT and MRI. Malignant (anaplastic) meningiomas are less common lesions, accounting for 1-2.8% of meningiomas. Recently, clear cell and chordoid meningiomas have been classified as WHO Grade II and rhabdoid and papillary meningiomas classified as WHO Grade III tumors without pathological criteria for malignancy. Here we report a rare case of rhabdoid meningioma in a 31 year-old man. Using the presented case we discuss the prognostic significance of recognition of a rhabdoid meningioma in light of the literature. Anahtar Kelimeler : Meningioma, rhabdoid meningioma, prognostic significance ...
Meningiomas account for around 25% of primary brain tumours, and most often occur between the age of 40 and 70 years. They are more common in females. Atypical meningiomas are more aggressive than benign meningiomas, and account for around 5% of all meningiomas. Around 4% of meningiomas are malignant ...
Secretory meningioma is a distinct subtype of meningioma. We describe the cytologic features of a secretory meningioma on squash preparations, in comparision with other cytologic mimickers. A 54-year-old woman presented with hearing loss, vertigo, tinnitus, and headache for seven years. A brain MRI study revealed a 4.5 cm sized mass in the cerebellopontine angle, which showed homogenous signal intensity in T2-weighted image. The intraoperative squash smear showed some well-defined, thin rimmed intracytoplasmic inclusions, containing a finely granular eosinophilic core among less cohesive meningiomatous cells. Histologic sections revealed a meningothelial meningioma with scattered inclusions, with periodic acid-Schiff, carcinoembryonic antigen, and cytokeratin positivity. Identification of characteristic intracytoplasmic inclusions is helpful for diagnosing secretory meningiomas. On squash preparations, differential diagnoses included tumors with inclusions or cytoplasmic vacuolizations, such as ...
TY - JOUR. T1 - Cognitive outcomes in meningioma patients undergoing surgery. T2 - Individual changes over time and predictors of late cognitive functioning. AU - Rijnen, S.. AU - Meskal, I.. AU - Bakker, M.. AU - Rutten, G.. AU - Gehring, K.. AU - Sitskoorn, M.. PY - 2018. Y1 - 2018. U2 - 10.1093/neuonc/noy139.387. DO - 10.1093/neuonc/noy139.387. M3 - Meeting Abstract. VL - 20. SP - iii317-iii317. JO - Neuro-Oncology. JF - Neuro-Oncology. SN - 1522-8517. IS - suppl 3. ER - ...
TY - THES. T1 - Cognitive functioning in meningioma patients. T2 - Insights in individual test performances and changes of performance after surgery. AU - Meskal, Ikram. PY - 2018. Y1 - 2018. M3 - Doctoral Thesis. SN - 978-94-6375-224-4. PB - Ridderprint. CY - s.l.. ER - ...
Background: Meningioma is a frequent primary intracranial tumor, the etiology of which is potentially related to adiposity. Metabolic syndrome (MetS) is an increasingly common disease characterized by having at least three of the following conditions: central adiposity, arterial hypertension, dyslipidemia, and insulin resistance. Only one prior study investigated MetS in relation to meningioma risk and found a positive association between the two. Results: Among 2,027 cases and 20,269 controls, body mass index was positively associated with meningioma (p-value for trend , 0.0001). Arterial hypertension was also associated with an increased risk of meningioma (OR = 1.34; 95% CI = 1.20-1.49). By comparison, high-density lipoprotein, triglycerides, fasting serum glucose, and use of ACE-inhibitors, AT-II inhibitors, beta-blockers, diuretics, calcium antagonists, nitrates, or statins were not associated with risk of meningioma. Materials and Methods: We conducted a matched case-control analysis using ...
Previous studies have reported inconsistent results on the effect of anthropometric and lifestyle factors on the risk of developing glioma or meningioma tumours. A prospective cohort of 1.3 million middle-aged women was used to examine these relationships. During 7.7 million women-years of follow-up, a total of 1563 women were diagnosed with a primary incident central nervous system tumour: 646 tumours were classified as glioma and 390 as meningioma. Our results show that height is related to the incidence of all central nervous system tumours with a risk of about 20% per 10 cm increase in height (relative risk=1.19, 95% CI=1.10-1.30 per 10 cm increase in height, P|0.001): the risks did not differ significantly between specified glioma and meningioma. Body mass index (BMI) was also related to central nervous system tumour incidence, with a risk of about 20% per 10 kg m(-2) increase in BMI (relative risk=1.17, 95% CI=1.03-1.34 per 10 kg m(-2) increase in BMI, P=0.02). Smoking status, alcohol intake,
see Venous infarction. Venous air embolism (VAE) during an elective craniotomy for parasagittal meningioma resection. The surgery was done in the supine position with slightly elevated head position. VAE was provisionally diagnosed by sudden decreased in the end tidal carbon dioxide pressure from 34 to 18 mmHg, followed by marked hypotension and atrial fibrillation. Prompt central venous blood aspiration, aggressive resuscitation and inotropic support managed to stabilize the patient. Post operatively, he was admitted in neuro intensive care unit and made a good recovery without serious complications 15).. Intraoperative fatal pulmonary embolism 16).. Paraparesis can occur as a primary presentation of brain pathology at the motor strip along the parasagittal region. It could also occur as a neurological complication especially following resection of parasagittal meningioma with infiltration of the superior sagittal sinus (SSS). We report a case of a complete paraparesis immediately following ...
Two years ago, Dr. Damon Reed approached Meningioma Mommas and asked if he could develop a survey regarding meningiomas and the effects they have with a focus on women with meningiomas deciding whether or not to have children. We are thrilled to share the following press release received today as well as the link to the article in the Journal of Neurosurgery. http://thejns.org/doi/full/10.3171/2014.11.JNS14522. Acknowledging the need for greater research on meningiomas is a win-win for all of us.. Decisions on Future Childbearing in Women Diagnosed with a Meningioma. Charlottesville, VA (January 27, 2015). The diagnosis of a brain tumor-even one thats usually benign and slow growing such as a meningioma-can be scary. Meningiomas can cause temporary and permanent side effects and sometimes may recur even after surgical removal. In addition, a small percentage of primary or recurrent meningiomas are malignant. Imagine yourself a female meningioma survivor in your childbearing years. Some ...
Optic nerve sheath meningiomas and optic nerve gliomas can be difficult to differentiate by computed tomography (CT). Three patients with optic nerve sheath meningiomas were studied with a CT/T 8800 scanner with 1.5-mm-thick axial sections and intravenous contrast material. In each case, an abnormal optic nerve sheath was identified by CT. A soft-tissue mass arose from one side of the sheath in one patient, and the entire sheath was enlarged in two patients. This provides a basis for distinguishing optic nerve sheath meningioma from optic nerve glioma. ...
TY - JOUR. T1 - Rapid growth and regression of intracranial meningiomas in lymphangioleiomyomatosis. T2 - case report. AU - Pozzati, Eugenio. AU - Zucchelli, Mino. AU - Schiavina, Mario. AU - Contini, Paola. AU - Foschini, Maria Pia. PY - 2007/12. Y1 - 2007/12. N2 - Background: Lymphangioleiomyomatosis is a progressive interstitial lung disease that affects young women. It has been suggested that estrogens play a role in its evolution, and progesterone therapy is often provided in these cases. Case Description: We present a case of a postmenopausal woman with LAM treated with progesterone; subsequently, rapid growth of multiple intracranial meningiomas was observed. One prominent lesion was excised, and 3 other lesions regressed spontaneously over 2 years. Conclusions: This is a rare case of a non-pregnancy-related regression of meningiomas in a woman affected by LAM. The significance of this association and the hormonal treatment of the disease are discussed.. AB - Background: ...
TY - JOUR. T1 - Precision radiation therapy for optic nerve sheath meningiomas. AU - Eng, Tony Y.. AU - Albright, N. W.. AU - Kuwahara, G.. AU - Akazawa, C. N.. AU - Dea, D.. AU - Chu, G. L.. AU - Hoyt, W. F.. AU - Wara, W. M.. AU - Larson, D. A.. PY - 1992. Y1 - 1992. N2 - A more precise radiation therapy technique to treat unilateral optic nerve sheath meningioma is presented. It uses an immobilization device to align the ipsilateral optic nerve with a vertical axis and employs three small half-beam blocked fields to deliver radiation to a small conformal volume, thereby reducing the dose to the optic chiasm and the contralateral optic nerve. Three patients were successfully treated with this technique, and a fourth patient with optic nerve glioma was also treated in a similar fashion and was included in this study. The new technique irradiates a much smaller volume of tissue to high dose levels: 58 cm3 is irradiated to the 80% isodose level and only 18 cm3 to the 95% level. In contrast, the ...
Meningioma is a primary central nervous tumour (CNS) affecting mostly adults. Skull base meningiomas cause morbidity (and occasionally mortality) by compressing adjacent critical organs, and the aim of treatment is to optimise and preserve CNS function. Radiotherapy is an effective treatment for meningioma, with doses of 50-54Gy in conventional fractionation schedules resulting in long-term local control rates of 80-90%. However, local recurrence is unacceptably high in aggressive histological subtypes (WHO G2 and G3), and these patients have a poor outcome following standard dose regimens. In recent years Intensity-Modulated Radiotherapy (IMRT) has been developed, and can deliver highly conformal dose distributions with sharp dose gradients, making dose escalation a possibility for many tumours, including those located in the skull base. The aim of this thesis was to address two issues pertaining to the role of radiotherapy for skull base meningioma. Firstly the goal was to investigate the ...
Hey guys! I am 37 years old & was recently diagnosed with an optic nerve sheath Meningioma. In a matter of three years I have lost all vision in my right eye. Most would think, as I did, you have 2 eyes- youll be okay with just one & boy […]
TY - JOUR. T1 - Endoscopic endonasal versus open transcranial resection of anterior midline skull base meningiomas. AU - Komotar, Ricardo J.. AU - Starke, Robert M.. AU - Raper, Daniel M.S.. AU - Anand, Vijay K.. AU - Schwartz, Theodore H.. PY - 2012/5/1. Y1 - 2012/5/1. N2 - Objective: To assess the advantages and limitations of the endoscopic endonasal approach to anterior skull base meningiomas, a minimally invasive approach that avoids extensive bone drilling, brain retraction, and manipulation of nerves and critical vessels, versus open transcranial surgery. Methods: A MEDLINE (2000-2010) search was performed to identify series for either olfactory groove meningiomas or tuberculum sellae (TS) or planum sphenoidale meningiomas. Statistical analyses of categorical variables such as extent of resection, morbidity, and visual outcome were performed using χ 2 and Fisher exact tests. Results: The literature review included 60 studies, involving 1426 patients. Open surgery achieved a higher rate ...
Management of Recurrent Skull Base Meningiomas Keywords: anaplastic, atypical, chemotherapy, endoscopic surgery, meningioma, microsurgery, minimally-invasive, radiosurgery, recurrence, skull base Sheri K. Palejwala, Garni Barkhoudarian, Walavan Sivakumar, Daniel F. Kelly Abstract Skull base meningiomas, due to their frequent investment or encasement of critical neurovascular structures, are challenging to resect in their entirety, both with initial resection…
Definition of meningotheliomatous meningioma. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms and definitions.
TY - JOUR. T1 - Addressing Misdiagnosis of Optic Nerve Sheath Meningiomas. AU - Kalen, Brian D.. AU - Hess, Ryan A.. AU - Abi-Aad, Karl R.. AU - Welz, Matthew E.. AU - Patra, Devi P.. AU - Sharma, Akanksha. AU - Mrugala, Maciej M.. AU - Porter, Alyx B.. AU - Bendok, Bernard R.. AU - Acierno, Marie D.. PY - 2020/1. Y1 - 2020/1. UR - http://www.scopus.com/inward/record.url?scp=85076866243&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=85076866243&partnerID=8YFLogxK. U2 - 10.1016/j.wneu.2019.10.122. DO - 10.1016/j.wneu.2019.10.122. M3 - Article. C2 - 31881557. AN - SCOPUS:85076866243. VL - 133. SP - 419. EP - 420. JO - World Neurosurgery. JF - World Neurosurgery. SN - 1878-8750. ER - ...
The authors present the technical and anatomical nuances needed to perform an endoscopic endonasal removal of a tuberculum sellae meningioma. The patient is a 47-year-old female with headaches and an incidental finding of a small tuberculum sellae meningioma with no vascular encasement, no optic canal invasion, but mild inferior to superior compression of the cisternal segment of the left optic nerve. Neuroophthalmology assessment revealed no visual defects. Treatment options included clinical observation with imaging follow-up studies, radiosurgery, and resection. The patient elected to undergo surgical removal and an endonasal endoscopic approach was the preferred surgical option. Preoperative radiological studies showed the presence of an osseous ring between the left middle and anterior clinoids, the so-called carotico-clinoidal ring. The surgical implications of this finding and its management are illustrated. The surgical anatomy of the suprasellar region is reviewed, including concepts ...
To evaluate the impact of 68Ga-DOTATOC-PET on treatment planning and sparing of normal tissue in the treatment of skull base meningioma with advanced photons and protons. From the institutional database consisting of 507 skull base meningiomas 10 patients were chosen randomly for the present analysis. Target volume definition was performed based on CT and MRI only, as well as with additional 68Ga-DOTATOC-PET. Treatment plans were performed for Intensity Modulated Radiotherapy (IMRT) and proton therapy using active raster scanning on both target volumes. We calculated doses to relevant organs at risk (OAR), conformity indices as well as differences in normal tissue sparing between both radiation modalities based on CT/MRI planning as well as CT/MRI/PET planning. For photon treatment plans, PET-based treatment plans showed a reduction of brain stem Dmax and Dmedian for different levels of total dose. At the optic chiasm, use of 68Ga-DOTATOC significantly reduces Dmax; moreover, the Dmedian is reduced in
TY - JOUR. T1 - Endoscopic transsphenoidal resection of a mid-clival meningioma. AU - Alexander, Hamish. AU - Robinson, Simon. AU - Wickremesekera, Agadha. AU - Wormald, Peter. PY - 2010/3. Y1 - 2010/3. N2 - Advances in transsphenoidal endoscopic surgery have allowed difficult clival tumours such as meningiomas causing effacement of the pons and basilar artery to be approached by this technique. We report a clival meningioma resected via a transsphenoidal endoscopic approach.. AB - Advances in transsphenoidal endoscopic surgery have allowed difficult clival tumours such as meningiomas causing effacement of the pons and basilar artery to be approached by this technique. We report a clival meningioma resected via a transsphenoidal endoscopic approach.. KW - Clivus. KW - Endoscope. KW - Meningioma. KW - Transsphenoidal approach. UR - http://www.scopus.com/inward/record.url?scp=75349085050&partnerID=8YFLogxK. U2 - 10.1016/j.jocn.2009.06.037. DO - 10.1016/j.jocn.2009.06.037. M3 - Article. VL - ...
Optic nerve sheath meningiomas (ONSM) are rare benign tumors of the optic nerve. 60-70% of cases occur in middle age females, and is more common in older adults (mean age 44.7 years). It is also seen in children, but this is rare. The tumors grow from cells that surround the optic nerve, and as the tumor grows, it compresses the optic nerve. This causes loss of vision in the affected eye.[1] Rarely, it may affect both eyes at the same time.[2] It is typically a slow growing tumor, and has never been reported to cause death. However, there is concern that the tumor can grow into the brain and cause other types of neurological damage. In some patients, the tumor grows so slowly that treatment is not necessary. Standard treatments are observation, surgery, radiation therapy, and combinations of the above.[1] ...
Detection of TP53 gene mutation in human meningiomas: A study using immunohistochemistry, polymerase chain reaction/single-strand conformation polymorphism and DNA sequencing techniques on paraffin-embedded samples ...
Contents: The Fundamentals.- The History of Stereotactic Radiosurgery.- Neuroimaging in Radiosurgery Treatment Planning and Follow-up Evaluation.- Techniques of Stereotactic Radiosurgery.- Radiation Biology and Physics.- The Physics of Stereotactic Radiosurgery.- Radiobiological Principles Underlying Stereotactic Radiation Therapy.- Experimental Radiosurgery Models.- Treatment Planning for Stereotactic Radiosurgery.- Designing, Building and Installing a Stereotactic Radiosurgery Unit.- Stereotactic Radiosurgery Techniques.- Gamma Knife Radiosurgery.- Linear Accelerator Radiosurgery.- Proton Beam Radiosurgery: Physical Bases and Clinical Experience.- Robotics and Radiosurgery.- CyberKnife Radiosurgery.- Treatment of Disease Types.- Brain Metastases.- Metastatic Brain Tumors: Surgery Perspective.- Brain Metastases: Whole-Brain Radiation Therapy Perspective.- High-Grade Gliomas.- Malignant Glioma: Chemotherapy Perspective.- Meningioma.- Meningioma: Surgery Perspective.- Intracranial Meningioma: ...
The authors report a novel technique of balloon-assisted embolization of a skull base meningioma supplied by a branch of the cavernous segment of the internal carotid artery using liquid embolic agent. A temporarily inflated balloon distal to the meningiomas feeding vessel may improve the access to this small branch and may reduce the chances of unintended reflux during delivery of the liquid embolic agent. ...
TY - JOUR. T1 - Morbidity and mortality associated with meningioma after cranial radiotherapy. T2 - A report from the childhood cancer survivor study. AU - Bowers, Daniel C.. AU - Moskowitz, Chaya S.. AU - Chou, Joanne F.. AU - Mazewski, Claire M.. AU - Neglia, Joseph P.. AU - Armstrong, Gregory T.. AU - Leisenring, Wendy M.. AU - Robison, Leslie L.. AU - Oeffinger, Kevin C.. PY - 2017/5/10. Y1 - 2017/5/10. N2 - Purpose: Little is known about neurologic morbidity attributable to cranial radiotherapy (CRT) -associated meningiomas. Materials and Methods: From 4,221 survivors exposed to CRT in the Childhood Cancer Survivor Study, a diagnosis of meningioma and onset of neurologic sequelae were ascertained. Cox proportional hazards regression was used to estimate hazard ratios (HR) and 95% CIs to evaluate the factors associated with neurologic sequelae after subsequent meningioma. Results: One hundred ninety-nine meningiomas were identified among 169 participants. The median interval from primary ...
TY - JOUR. T1 - Skull base meningiomas. AU - Couldwell, William T.. AU - Heros, Roberto. AU - Dolenc, Vinko. PY - 2011/5. Y1 - 2011/5. UR - http://www.scopus.com/inward/record.url?scp=84858619086&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84858619086&partnerID=8YFLogxK. U2 - 10.3171/2011.3.FOCUS1185. DO - 10.3171/2011.3.FOCUS1185. M3 - Editorial. C2 - 21529181. AN - SCOPUS:84858619086. VL - 30. JO - Neurosurgical Focus. JF - Neurosurgical Focus. SN - 1092-0684. IS - 5. ER - ...
TY - JOUR. T1 - Intratumoral microhemorrhages on T2*-weighted gradient-echo imaging helps differentiate vestibular schwannoma from meningioma. AU - Thamburaj, K.. AU - Radhakrishnan, V.V.. AU - Thomas, B.. AU - Nair, S.. AU - Menon, G.. N1 - cited By 43. PY - 2008. Y1 - 2008. N2 - BACKGROUND AND PURPOSE: Vestibular schwannomas (VS) may be difficult to differentiate from cerebellopontine angle (CPA) meningiomas. Demonstration of microhemorrhages in VS on T2*-weighted gradient-echo (GRE) sequences may have potential value to differentiate VS from CPA meningiomas. MATERIALS AND METHODS: In this prospective study of 20 patients, MR imaging was performed with T2*-weighted GRE in addition to all basic sequences. Histopathologic examination was performed after surgery. Intratumoral hemosiderin was confirmed by pigment staining. RESULTS: There were 15 patients in the VS group with 16 VS and 5 in the meningioma group with 5 posterior fossa meningiomas. Fourteen of the 16 VS and all 5 meningiomas were ...
MORALES, F. et al. Skull base meningiomas: a predictive system to know the extent of their surgical resection and patient outcome. Neurocirugía [online]. 2005, vol.16, n.6, pp.477-485. ISSN 1130-1473.. Objective. The aim of this study was to build a preoperative predictive system which could pro-vide reliable information about: 1° which skull base meningiomas can be total or partially removed, and 2° their surgical outcome. Method. Patient histories and imaging data were reviewed retrospectively from 85 consecutive skull base meningiomas patients who underwent surgery from 1990 and 2002. From the preoperative data, nine variables were selected for conventional statistical analysis as regards their relationship with: 1° total vs partial tumor resection and 2° with patients outcome according to the degree of tumour removal. Results. From the nine variables analysed only two had a statistical association with the type of tumour resection performed (total vs partial) and the patient outcome: 1) ...
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Meningiomas are a diverse set of tumors arising from the meninges, the membranous layers surrounding the central nervous system. They arise from the arachnoid cap cells of the arachnoid villi in the meninges. These tumors usually are benign in nature; however, a small percentage are malignant. Many meningiomas produce no symptoms throughout a persons life, and if discovered, require no treatment other than periodic observation. Typically, symptomatic meningiomas are treated with either radiosurgery or conventional surgery. Historical evidence of meningiomas has been found going back hundreds of years, with some successful surgeries for their removal beginning in the 1800s. ...
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Primary Middle Ear Meningioma and Dural/ Ophthalmic Artery Aneurysm Meningiomas are the second most common brain tumor. Though most are found intracranially, a few exhib..
Primary Middle Ear Meningioma and Dural/ Ophthalmic Artery Aneurysm Meningiomas are the second most common brain tumor. Though most are found intracranially, a few exhib..
This morning CNN fed a headline: Sheryl Crow: Brain Tumor is a Bump in the Road. This concerned me, not only because Im a huge fan, but because in 2006, she began treatment for breast cancer at age 43. Singer-songwriter Sheryl Crow says she has a brain tumor, says the first line of the CNN story. I was concerned. It seemed liked shed been getting a little bit closer…to feeling fine.. Fortunately, the LATimes and People magazine got Crows story right. Their headlines, and text, emphasize the benign nature of Crows newly-diagnosed condition, a meningioma. Most meningiomas are benign, local expansions of the cells that line the brain and spinal cord. These growths occasionally cause neurological symptoms. Some patients have surgery to relieve or avoid complications of these non-malignant growths, but many dont need intervention ...
TY - JOUR. T1 - The evolving role of radiosurgery in the management of radiation-induced meningiomas. T2 - A review of current advances and future directions. AU - Mansouri, Alireza. AU - Badhiwala, Jetan. AU - Mansouri, Sheila. AU - Zadeh, Gelareh. N1 - Publisher Copyright: © 2014 Alireza Mansouri et al. Copyright: Copyright 2015 Elsevier B.V., All rights reserved.. PY - 2014. Y1 - 2014. N2 - Meningiomas are among the most common primary adult brain tumors, which arise either spontaneously or secondary to environmental factors such as ionizing radiation. The latter are referred to as radiation-induced meningiomas (RIMs) which, while much less common than their spontaneous counterparts, are challenging from a management point of view. Similar to spontaneous meningiomas, the optimal management of RIMs is complete surgical resection. However, given their high grade, multiplicity, tendency to invade bone and venous sinuses, and high recurrence rate, this cannot always be accomplished safely. ...
The International Agency for Research on Cancer (IARC) has published the results of the INTERPHONE combined analysis for glioma and meningioma and found overall no increased risk of brain cancer from mobile phone use.. In announcing the results for glioma and meningioma, Dr Christopher Wild, Director of the International Agency for Research on Cancer (IARC) said:. An increased risk of brain cancer is not established from the data from INTERPHONE. However, observations at the highest level of cumulative call time and the changing patterns of mobile phone use since the period studied by INTERPHONE, particularly in young people, mean that further investigation of mobile phone use and brain cancer risk is merited.. The INTERPHONE researchers conclude:. Overall, no increase in risk of glioma or meningioma was observed with use of mobile phones. There were suggestions of an increased risk of glioma at the highest exposure levels, but biases and error prevent a causal interpretation. The possible ...
Doctors give unbiased, trusted information on the use of Gamma Knife Surgery for Meningioma: Dr. Bonuel on radiation necrosis after gamma knife surgery for meningioma: Stereotactic surgery is usually a minimally invasive procedure using x-ray and computers to locate a spot or lesion to perform a needle biopsy through a very small incision. Gamma knife is a non-invasive procedure to deliver very carefully a high dose of radiation therapy with specialized equipment to treat a lesion or tumor with no incision.
This multicentre case-control study of 1906 cases and 5565 controls provides no evidence of any association between occupational exposure to organic solvents and meningioma in the overall study population or in women or men separately. There were also no significant trends of increasing risk with either increasing cumulative exposure or duration of exposure. However, interpretation of these negative findings should take into account the strengths and limitations of the study.. While the INTEROCC study is the largest case-control study conducted to date investigating associations between occupational exposure to organic solvents and meningioma, the relatively low-exposure prevalence in the study population limited its power to identify significant associations and in particular after stratification by gender. Potential sources of selection and recall bias in the design and conduct of the INTERPHONE study on which this study was based have been addressed in detail elsewhere;28 ,36 however, these ...
abstractNote = {A 12 year-old girl was treated with prophylactic cranial irradiation for acute lymphoblastic leukaemia (ALL). At the age of 39, she was admitted to our hospital for status epilepticus. Computed tomography demonstrated two, enhancing bilateral sided intracranial tumors. After surgery, this patient presented meningiomas which histologically, were of the meningothelial type. The high cure rate in childhood ALL, attributable to aggressive chemotherapy and prophylactic cranial irradiation, is capable of inducing secondary brain tumor. Twelve cases of high-dose radiation-induced meningioma following ALL are also reviewed. (author ...
CASE REPORTS Journal of Neurosurgical Sciences 2004 June;48(2):59-62. Solitary fibrous tumor of the tentorium cerebelli. Case report. Pérez-Núñez A., Rivas J. J., Ricoy J. R., Miranda P., Arrese I., Lobato R. D., Ramos A.. Abstract PDF. CASE REPORTS Journal of Neurosurgical Sciences 2004 June;48(2):63-5. Spontaneous rupture of spinal dermoid cyst with disseminated lipid droplets in central canal and ventricles. Goyal A., Singh D., Singh A. K., Gupta V., Sinha S.. Abstract PDF. CASE REPORTS Journal of Neurosurgical Sciences 2004 June;48(2):67-70. Neurological deterioration after head trauma in patients with colloid cysts of the 3rd ventricle. Two case histories. Cultrera F., Parisi G., Platania N., Consoli V., Albanese V.. Abstract PDF. CASE REPORTS Journal of Neurosurgical Sciences 2004 June;48(2):71-73. Metastasis of breast carcinoma to intracranial meningioma. Baratelli G. M., Ciccaglioni B., Dainese E., Arnaboldi L.. Abstract PDF. CASE REPORTS Journal of Neurosurgical Sciences 2004 ...
PRIMARY OBJECTIVES:. I. To determine the efficacy of bevacizumab in patients with recurrent or progressive benign and atypical/malignant meningiomas, despite prior therapy, as measured by six-month progression-free survival.. SECONDARY OBJECTIVES:. I. To describe the response rate and overall-survival in this patient population.. II. To evaluate the safety profile of bevacizumab in patients with recurrent meningiomas.. III. To perform an exploratory study in patients with hemangioblastoma and hemangiopericytoma.. IV. To assess tissue for VEGF and VEGFR to correlate with response. An exploratory analysis of HER-2 will be performed.. OUTLINE:. Patients receive bevacizumab IV over 30-90 minutes every 2 weeks for 6 months. Patients may then receive bevacizumab IV every 3 weeks for up to 12 months. Treatment continues in the absence of disease progression or unacceptable toxicity.. After completion of study treatment, patients are followed every 3 months for 2 years. ...
A case of haemangiopericytic meningioma of the sacral canal in a 25 year old man, an uncommon tumour at a rare site, is described. The tumour was malignant and largely undifferentiated although there was light and electron microscopic evidence of dual differentiation in areas towards haemangiopericytoma and meningioma. The patient, with cauda equina syndrome, was treated by partial resection and post-operative radiotherapy and remains well 12 months after treatment.. ...
TY - JOUR. T1 - Meningiomas of the tuberculum and diaphragma sellae. AU - Ajlan, Abdulrazag M.. AU - Choudhri, Omar. AU - Hwang, Peter. AU - Harsh, Griffith. PY - 2015/2. Y1 - 2015/2. N2 - Introduction Although tuberculum sellae (TS) and diaphragma sellae (DS) meningiomas have different anatomical origins, they are frequently discussed as a single entity. Here we review the radiologic and intraoperative findings of TS and DS meningiomas and propose a radiologic classification. Methods We retrospectively reviewed 10 consecutive TS and DS meningiomas. Data regarding clinical presentation, preoperative imaging, and intraoperative findings were analyzed. Three sellar dimensions were measured on magnetic resonance imaging (MRI): the tuberculum-sellar floor interval (TSFI), the planum-tuberculum interval (PTI), and the total height. Results Three distinct anatomical patterns were recognized: exclusively tubercular meningiomas (type A) were accompanied by elongation of the TSFI and, more significantly, ...
There has been a lot of talk in the press lately about dental x-rays and their possible links to a specific brain tumor known as intracranial meningioma. The study that was covered extensively on national news was conducted by asking to two groups of people about their history of dental x-rays. One group had the […] ...
2The Second Affiliated Hospital of Xinjiang Medical University, Department of Neurosurgery, Urumqi, China DOI : 10.5137/1019-5149.JTN.8670-13.1 AIM: This study aimed to investigate the operative procedure for neuroendoscope-assisted microscopic resection of petroclival meningioma to improve prognosis.. MATERIAL and METHODS: Twelve patients with petroclival meningioma who had undergone neuroendoscope-assisted microscopic resection at the Department of Neurosurgery, First Affiliated Hospital of Xinjiang Medical University were selected. In addition, 12 patients with petroclival meningioma who had undergone microscopic surgery were used as control. Clinical data from the 24 cases of petroclival meningioma were analyzed.. RESULTS: For the neuroendoscope-assisted group, six, five, and one cases were respectively subjected to total resection, subtotal resection, and most resection. For the microscopic surgery group, two, three, and seven cases were respectively subjected to total resection, subtotal ...
People who have had frequent dental X-rays may have an increased chance of developing a meningioma, one of the most commonly diagnosed brain tumors, according to a new study. Most meningiomas are non-malignant, but they can grow very large. Depending upon their location in the skull, they can also cause severe symptoms like memory loss, frequent headaches, vision and hearing loss and seizures. Ionizing radiation, such as X-rays, is the biggest risk factor for developing a meningioma.
TY - JOUR. T1 - Meningioma rabdoide Grado III, en paciente pediátrico: Reporte de caso. AU - Velandia Hurtado, Fernando Alfredo. AU - Rojas, Luis Orlando. AU - Restrepo Fernandez, Carlos Martin. AU - Martinez , Andreina AU - Mendoza, María Mercedes AU - Cuellar, Yulina PY - 2017/5/28. Y1 - 2017/5/28. N2 - Los Meningiomas Rabdoides son una variante poco común de los meningiomas grado III según la clasificación WHO de 2016con alto índice mitótico, invasión a tejido cerebral sano, alta tasa de recurrencia y baja expectativa de sobrevida, en estaoportunidad presentamos el caso clínico de una paciente de 23 meses de edad diagnosticada con esta patología, abarcandobrevemente aspectos clínicos característicos de la patología, histopatología del diagnóstico y una revisión corta de la literaturaactual sobre el tratamiento y la sobrevida de estos pacientes.. AB - Los Meningiomas Rabdoides son una variante poco común de los meningiomas grado III según la clasificación WHO de 2016con alto ...
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Meningioma growth has been previously described in patients receiving oestrogen/progestogen therapy. We describe the clinical, radiological, biochemical and pathologic findings in a 45-year-old woman with congenital adrenal hyperplasia secondary to a defect in the 21-hydroxylase enzyme who had chronic poor adherence to glucocorticoid therapy with consequent virilisation. The patient presented with a frontal headache and marked right-sided proptosis. Laboratory findings demonstrated androgen excess with a testosterone of 18.1 nmol/L (0-1.5 nmol) and 17-Hydroxyprogesterone ,180 nmol/L (,6.5 nmol/L). CT abdomen was performed as the patient complained of rapid-onset increasing abdominal girth and revealed bilateral large adrenal myelolipomata. MRI brain revealed a large meningioma involving the right sphenoid wing with anterior displacement of the right eye and associated bony destruction. Surgical debulking of the meningioma was performed and histology demonstrated a meningioma, which stained ...
Thirteen meningiomas of varying light microscopic features were studied immunohistologically using a panel of monoclonal antibodies directed against epithelial, mesenchymal, and neural components. All 13 meningiomas showed expression of epithelial membrane antigen, vimentin, and S100 protein, as did normal meninges. Five of the 13 meningiomas also showed focal expression of cytokeratins, with double labelling showing expression of cytokeratins and vimentin by different cells. The cytokeratin expression was especially noticeable in cells surrounding the hyaline bodies of meningiomas. These results provide further evidence that meningiomas have features of both mesenchymal and epithelial tissues.. ...
Meningioma is a cranial disorder and is characterised by tumor growth on the meninges, surrounding the blood vessels and nerves ... Other diseases include meningioma, a tumor surrounding essential blood vessels and nerves that may be near the crown, causing ... "Meningioma - Symptoms and Causes". www.pennmedicine.org. Retrieved 2020-10-21. Berger, A. (2002-01-05). "How does it work?: ... The patients that have meningioma develop signs and symptoms including amnesia and epileptic seizures. The direct impact to the ...
Gil M, Oliva B, Timoner J, Maciá MA, Bryant V, de Abajo FJ (December 2011). "Risk of meningioma among users of high doses of ... A hemangioblastoma mimicking a meningioma has been reported in a man treated with CPA. The combination of low-dose (2 mg) CPA ... Raj R, Korja M, Koroknay-Pál P, Niemelä M (2018). "Multiple meningiomas in two male-to-female transsexual patients with hormone ... Ter Wengel PV, Martin E, Gooren L, Den Heijer M, Peerdeman SM (December 2016). "Meningiomas in three male-to-female transgender ...
... showed that the owner of the skull suffered from a meningioma, which is an arachnoid tumor. Meningiomas are a diverse set of ... Meningiomas are very rare with roughly 2 out of 100,000 causing symptoms, so finding evidence of one in such ancient remains is ... It is the earliest evidence of a meningioma tumor on record. List of fossil sites (with link directory) List of hominina ( ... It is also possible that no neurological deficiencies were suffered, due to the slow growing nature of meningiomas. Whether the ...
ISBN 9781598848311 Chan, Amanda, "What's a meningioma? The science of Mary Tyler Moore's brain tumor" NBCNews.com (May 12, 2011 ...
In 2011 she had surgery to remove a meningioma, a benign brain tumor. In 2014, friends reported that Moore had heart and kidney ... ISBN 9781598848311 Chan, Amanda, "What's a meningioma? The science of Mary Tyler Moore's brain tumor" NBCNews.com (May 12, 2011 ... Goldmann, Russell (May 12, 2011). "Mary Tyler Moore Has Brain Surgery for Meningioma Tumor". ABC News. Retrieved July 6, 2019. ...
"Meningiomas". Medmerits: 2. Archived from the original on 2012-03-31. Retrieved 2011-09-19. Ozaki N, Mukohara N, Yoshida M, ... They have a grade 2 or 3 biological behavior, and need to be distinguished from benign meningiomas because of their high rate ... When inside the nervous system, although not strictly a meningioma tumor, it is a meningeal tumor with a special aggressive ... Maier H, Ofner D, Hittmair A, Kitz K, Budka H (1992). "Classic, atypical, and anaplastic meningioma: three histopathological ...
Wood was diagnosed in 1910 with a benign meningioma, which was successfully resected by Harvey Cushing. Wood made a full ... Lee, Joung H. (2009). Meningiomas: Diagnosis, Treatment, and Outcome. Springer. p. 8. ISBN 978-1-84882-910-7. "Burial Detail: ...
Adjuvant radiotherapy for atypical meningiomas (2017) Couldwell, WT; Bagshaw, HP; Burt, LM; Suneja, G; Jensen, RL; Palmer, CA ( ... A description of familial clustering of meningiomas in the Utah population (2017) Couldwell, WT; CannonAlbright, LA (2017). "A ... Clinical Outcomes with Transcranial Resection of the Tuberculum Sellae Meningioma (2017) Couldwell, WT; CannonAlbright, LA ( ... 2017). "Clinical Outcomes with Transcranial Resection of the Tuberculum Sellae Meningioma". World Neurosurgery. 108: 748-755. ...
A series of case reports have found it to be effective in the treatment of an estrogen receptor (ER)-dependent meningiomas as ... 470-. ISBN 978-0-08-045593-8. Joung H. Lee (11 December 2008). Meningiomas: Diagnosis, Treatment, and Outcome. Springer Science ... on the regression of intracranial meningiomas in the elderly]". Brain Nerve (in Japanese). 66 (8): 995-1000. PMID 25082321. ... "Regression of a presumed meningioma with the antiestrogen agent mepitiostane". Journal of Neurosurgery. 93 (1): 132-135. doi: ...
"Near-infrared fluorescent image-guided surgery for intracranial meningioma". Journal of Neurosurgery. 128 (2): 380-390. doi: ...
The mass was determined to be an atypical Meningioma. Walsh underwent radiation treatments and chemotherapy upon recovering ...
Lim, E; Yik J; Pek C; Seet R (2007). "Infratentorial meningioma causing ipsilateral hemiparesis: The other Kernohan's notch?". ...
"Surgical Treatment of Olfactory Groove Meningiomas." In: AANS Neurosurgical Operative Atlas, pages 77-85, 1991. Bederson JB. " ...
Human brain tumors (e.g., Meningioma) Kauke, Martin Kauke and Ali-Farid Safi (January 2019). "Image segmentation-based volume ... https://journals.lww.com/jcraniofacialsurgery/Fulltext/2019/12000/Does_Meningioma_Volume_Correlate_With_Clinical.144.aspx Main ...
Along with Ludwig G. Kempe, Blaylock published a novel transcallosal approach to excising intraventricular meningiomas of the ... "Surgical Approaches to Intraventricular Meningiomas of the T... : Neurosurgery". Journals.lww.com. Retrieved 2010-01-13. Kempe ... "Hydrosyringomyelia of the conus medullaris associated with a thoracic meningioma". 54 (6). The Journal of Neurosurgery. Cite ...
Polyzoidis S, Koletsa T, Panagiotidou S, Ashkan K, Theoharides TC (September 2015). "Mast cells in meningiomas and brain ...
"Mast cells in meningiomas and brain inflammation". J Neuroinflammation. 12 (1): 170. doi:10.1186/s12974-015-0388-3. PMC 4573939 ...
Polyzoidis S, Koletsa T, Panagiotidou S, Ashkan K, Theoharides TC (2015). "Mast cells in meningiomas and brain inflammation". J ...
In the late 1890s, he was a pioneer of meningioma surgery. Marchi fixative: A substance used to demonstrate degenerating myelin ...
Later, a brain scan revealed a meningioma tumor in Howard's brain. Although the tumor was benign, she opted to have it removed ...
A 51 year old man with neck pain (foramen magnum meningioma)". New England Journal of Medicine. 301: 147-54. Samuels, MA; ...
It was soon revealed that he had a meningioma brain tumor; Weber successfully underwent surgery on November 17. The rest of the ...
Chynn, E. W.; Chynn, K. Y.; DiGiacinto, G. V. (1994-08-01). "Cystic lumbar meningioma presenting as a ring enhancing lesion on ... Chynn EW, Chynn KY, DiGiacinto G. Cystic lumbar meningioma presenting as a ring-enhancing lesion on MRI. Neuroradiology. 36(6 ...
Sioka C, Kyritsis AP (March 2009). "Chemotherapy, hormonal therapy, and immunotherapy for recurrent meningiomas". J. Neurooncol ...
"Risk of meningioma and common variation in genes related to innate immunity". Cancer Epidemiol. Biomarkers Prev. 19 (5): 1356- ...
Active ossifying fibroma must be separated from fibrous dysplasia, cementoblastoma, and meningioma. This type of separation ...
In 1990, Cass was diagnosed with meningioma, a type of brain tumour. As a result, her eye had to be replaced with a prosthetic ...
McCormick WE, Lee JH (May 2002). "Pseudobulbar palsy caused by a large petroclival meningioma: report of two cases". Skull Base ...
Radiation-induced meningiomas are an uncommon complication of cranial irradiation. Some people, such as those with nevoid basal ... Yamanaka R, Hayano A, Kanayama T (January 2017). "Radiation-Induced Meningiomas: An Exhaustive Review of the Literature". World ...
The most common type of intradural-extramedullary tumors are meningiomas and nerve-sheath tumors. The most common type of ... Neurofibromas are associated with neurofibromatosis 1 (NF1). Meningiomas and schwannomas are associated with neurofibromatosis ... with the most common being meningiomas and nerve sheath tumors (e.g. schwannomas, neurofibromas). Extradural tumors are located ...
Meningiomas may appear at any age, but most commonly are noticed in men and women age 50 or older, with meningiomas becoming ... Meningiomas often are considered benign tumors that can be removed by surgery, but most recurrent meningiomas correspond to ... Many individuals have meningiomas, but remain asymptomatic, so the meningiomas are discovered during an autopsy. One to two ... 3.3 years for anaplastic meningiomas. Mean relapse-free survival for atypical meningiomas was 11.5 years vs. 2.7 years for ...
Malignant meningioma is a rare, fast-growing tumor that forms in one of the inner layers of the meninges (thin layers of tissue ... Malignant meningioma entry in the public domain NCI Dictionary of Cancer Terms This article incorporates public domain material ... The World Health Organization classification system defines both grade II and grade III meningiomas as malignant. Historically ... Benign or low grade meningiomas (WHO grade I) include meningothelial, fibrous, transitional, psammomatous, angiomatous, ...
A sphenoid wing meningioma is a benign brain tumor near the sphenoid bone. A meningioma is a benign brain tumor. It originates ... Meningiomas are much more common in females, and are more common after 50 years of age. Of all cranial meningiomas, about 20% ... Meningiomas. New York: Raven Press, 1991. Bonnal J, A Thibaut, J Brotchi, and J Born. Invading Meningiomas of the Sphenoid ... Tumors found in the external third of the sphenoid are of two types: en-plaque and globoid meningiomas. En plaque meningiomas ...
... recently diagnosed with a meningioma, or brain tumour (in this case, a tumour of the protective membranes around the brain and ... A woman writes in to get advice for her friend, recently diagnosed with a meningioma, or brain tumour (in this case, a tumour ... Finally, one reader was successfully treated for two meningiomas in 1999 at Johns Hopkins Hospital in Baltimore, Maryland, with ...
This information is about meningioma in adults. Learn more here. ... A meningioma is a type of brain tumour. It is a tumour that ... What is a meningioma?. Meningiomas are a type of brain tumour. A meningioma is a tumour that starts in the meninges. The ... Treatment for meningioma. The main treatments for meningiomas are surgery and radiotherapy You may have a combination of ... Meningiomas can be graded as 1, 2 or 3:. *Grade 1 meningiomas are the most common type. These tumours are slow growing. If all ...
Meningiomas can be low to high grade (grades I - III). Grade I is the most common type of meningioma. Meningiomas account for ... Meningioma starts in the cells of the membranes that cover the brain and spinal cord (meninges). ... Meningioma. Meningiomas start in the cells of the membranes that cover the brain and spinal cord (meninges). Meningiomas can be ... Meningioma occurs more often in women. Benign meningioma. Benign meningiomas are low-grade (grade 1) tumours that account for ...
Is there a clear role for the use of adjuvant radiotherapy in the management of meningioma? What impact does it have on ... Meningothelial Meningioma. Fibrous Meningioma. Psammomatous Meningioma. Angiomatous Meningioma. Transitional Meningioma. ... Clear Cell Meningioma. Atypical Meningioma. Total. Meningioma, Malignant. Papillary Meningioma. Variable. No.. %. No.. %. No.. ... Atypical/Borderline Meningioma. Anaplastic Meningioma. Total. Meningiomatosis, NOS. ...
B, CT scan of another orbital meningioma arising from the sphenoid wi ... Right proptosis and fullness of the right temple secondary to sphenoid wing meningioma. ... B, CT scan of another orbital meningioma arising from the sphenoid wing (arrow). C, T1-weighted MRI. Note hyperostosis of the ... A, Right proptosis and fullness of the right temple secondary to sphenoid wing meningioma. ...
Chordoid meningioma, which is assigned to WHO grade II (atypical meningioma), is a rare meningioma that is sometimes associated ... Ozen O., Sar A., Atalay B., Altinors N., Demirhan B . Chordoid meningioma: rare variant of meningioma. Neuropathology 2004; 24 ... Nakano, S., Kanamori, A., Nakamura, M. et al. Paraneoplastic optic neuropathy associated with cerebellar choroid meningioma. ... The histopathological diagnosis of the tumor was chordoid meningioma. The patient felt visual improvement at the next day after ...
Sphenoid wing meningiomas form in the skull base behind the eyes.. *Olfactory groove meningiomas form along the nerves that run ... Recurrent meningiomas are any meningiomas that return after treatment. They may share the same characteristics as the initial ... including meningiomas. Meningiomas are the most common type of brain tumor, are typically benign, and may remain for years ... The Stanford Meningioma Program combines a multidisciplinary clinical care team with a strong clinical and research program, in ...
Meningioma Center offers individualized treatment plans providing the safest and least invasive options to address meningioma. ... Learn more about meningiomas and meningioma grading in our Health Library. *Listen to a podcast by Dr. Jon Weingart on ... Convexity Meningioma: Jills Story. Hollywood stunt woman, Jill Brown, was diagnosed with a benign convexity meningioma brain ... Our meningioma research is leading the way toward better understanding the origins and characteristics of meningioma. For ...
Find out about meningioma symptoms, diagnosis and treatment. ... Meningioma is the most common type of tumor that forms in the ... But the relationship between obesity and meningiomas is not clear.. Complications. A meningioma and its treatment, typically ... Most signs and symptoms of a meningioma evolve slowly, but sometimes a meningioma requires emergency care. ... A meningioma is a tumor that arises from the meninges - the membranes that surround your brain and spinal cord. Although not ...
The meningioma survival rate is higher than that associated with most other types of brain tumors, primarily because ... Have benign (rather than atypical or malignant) meningiomas. *Undergo a full resection, in which an entire tumor (rather than ... Patients who turn to Moffitts Neuro-Oncology Program for meningioma treatment can work with some of the most experienced and ... Our oncologists specializing in brain cancer can provide you with additional information regarding the meningioma survival rate ...
This is the first page of Cancer.Nets Guide to Meningioma. Use the menu to see other pages. Think of that menu as a roadmap ... Convexity meningioma. This type of meningioma occurs on the outer surface of the brain. It makes up about 20% of meningiomas. ... Malignant meningioma may be called anaplastic.. Subtypes of meningioma. Meningioma is often classified based on where it starts ... Posterior fossa meningioma. Posterior fossa meningioma develops at the back of the brain. It makes up 10% of all meningiomas. ...
... Zhen Zeng,1 Tijiang Zhang,1 Yihua Zhou,2 and Xiaoxi Chen1 ... Zhen Zeng, Tijiang Zhang, Yihua Zhou, and Xiaoxi Chen, "Atypical Growth Pattern of an Intraparenchymal Meningioma," Case ...
You will learn about the different treatments doctors use for people with meningioma. Use the menu to see other pages. ... A gamma knife can only be used for meningioma in the brain, not meningioma on the spine. ... For meningioma, it is the most common treatment. It is often the only treatment needed for a person with a noncancerous tumor ... Recovery from meningioma is not always possible. If the tumor cannot be cured or controlled, the disease may be called advanced ...
A meningioma is a type of abnormal growth of cells that develops from the membranes that surround and protect the brain. ... Meningioma surgery to remove the tumor may have risks, such as infection and damage to other areas of the brain. A meningioma ... Even if a meningioma is not cancerous, it may require treatment. The type of treatment needed will depend on the size of the ... Recovery from a meningioma and its treatment may depend on the overall health of the patient, size of the tumor and the ...
Meningioma Treatment Information A meningioma is a common type of tumor that can develop in the tissues that cover the brain or ... Small meningiomas occasionally go unnoticed, but large tumors often interfere with neurological function. As a result, patients ... To learn more about our approach to meningioma treatment, or to schedule an appointment with one of our oncologists who ... Patients who turn to Moffitt for meningioma treatment can access all of these treatment services in a single, convenient ...
I get those too? I just had my yearly MRI last night and see the Neuro thursday. They come and go? I was told once that they are focal seizures? Some Drs have no clue? I think it has to be b/c of... more ...
W. B. Wilson, "Meningiomas of the anterior visual system," Survey of Ophthalmology, vol. 26, no. 3, pp. 109-127, 1981. View at ... M. F. Mafee, J. Goodwin, and S. Dorodi, "Optic nerve sheath meningiomas. Role of MR imaging," Radiologic Clinics of North ... Optic Nerve Sheath Meningioma Masquerading as Optic Neuritis. R. Alroughani1,2 and R. Behbehani2,3 ... J. J. Dutton, "Optic nerve sheath meningiomas," Survey of Ophthalmology, vol. 37, no. 3, pp. 167-183, 1992. View at Publisher ...
Meningiomas account for approximately 25% of all spinal tumors. ... Meningiomas are the second most common tumor in the intradural ... encoded search term (Imaging in Spinal Meningioma) and Imaging in Spinal Meningioma What to Read Next on Medscape. Related ... Meningiomas account for approximately 25% of all spinal tumors. Approximately 80% of spinal meningiomas are located in the ... Most spinal meningiomas demonstrate broad-based dural attachment. On occasion, a densely calcified meningioma may demonstrate ...
Optic nerve sheath meningioma Parts A, C reprinted from Arnold AC. Optic nerve meningioma. Focal Points: Clinical Modules for ... C, "Ring sign" in meningioma. Coronal orbital MRI scan shows similar optic nerve sheath enhancement surrounding relatively ...
A meningioma is a brain tumor originating in the membranous layers around the brain that, depending on its location, may cause ... What are the symptoms of a brain meningioma?. A: The symptoms of a brain meningioma include headaches, blurred vision, arm and ... A meningioma is a brain tumor originating in the membranous layers around the brain that, depending on its location, may cause ... A malignant meningioma is an especially aggressive tumor, and its removal can be complicated by invasion into other tissues, ...
Meningioma comprises about one fourth of all primary tumors of the central nervous system (CNS). It is the most common primary ... In general, atypical meningiomas and anaplastic meningiomas comprise less than 10% of all meningiomas. [1] ... Atypical meningiomas and anaplastic meningiomas are usually larger. The cut surfaces of benign meningiomas are usually granular ... Although some of the observed variants, such as chondroid meningiomas, clear-cell meningiomas, papillary meningiomas, and ...
... surgery to remove a recurrent intraventricular meningioma from a patients brain. ... Pre-surgical scan shows a massive 6cm meningioma in the ventricle.. Post-surgical scan shows the successful removal of the ... A 45-year-old woman who had surgery six years prior for an intraventricular meningioma developed progressive headaches and ... The post-surgical MRI shows complete removal of the meningioma. The patients symptoms completely resolved. Treatment and ...
The INTEROCC case-control study: risk of meningioma and occupational exposure to selected combustion products, dusts and other ...
... You are looking at 1 - 1 of 1 items for * All content x ... COVID-19 Leksell Top 25 - Meningioma Leksell Top 25 - Vestibular Schwannoma Leksell Top 25 - Since 2005 Top 25 Cited Gamma ... Parasellar and sellar meningiomas are challenging tumors owing in part to their proximity to important neurovascular and ... Gamma Knife radiosurgery provides a high rate of tumor control for patients with parasellar or sellar meningiomas, and tumor ...
One hundred fifteen patients with cavernous sinus meningiomas, excluding atypical or malignant meningiomas, were treated with ... Leksell Top 25 - Meningioma. You are looking at 1 - 2 of 2 items for * All content x ... COVID-19 Leksell Top 25 - Meningioma Leksell Top 25 - Vestibular Schwannoma Leksell Top 25 - Since 2005 Top 25 Cited Gamma ... Gamma Knife surgery is a safe and effective treatment over the long term in selected patients with cavernous sinus meningiomas ...
Treating Meningioma at Florida Hospital Zephyrhills. From common to complex, we at Florida Hospital Zephyrhills treat a wide ... To find out more about how we treat Meningioma contact us below. ... Learn more about Meningioma. *What is Meningioma?. *Causes of ...
  • Patients with globoid meningiomas often present only with signs of increased intracranial pressure. (wikipedia.org)
  • Meningiomas are the most common form of primary intracranial tumour in adults and are associated with the neurogenetic syndrome neurofibromatosis type 2 (NF2). (springer.com)
  • Non-contrast Computed Tomography (CT) scan had shown an expansive intracranial process in the left parietal region which was radiologically diagnosed as a meningioma. (biomedsearch.com)
  • Intracranial meningioma. (ajnr.org)
  • Dental x-ray exposure has been linked to increased risk (up to 4.9 times higher) of intracranial meningioma. (greenmedinfo.com)
  • Meningioma is a relatively common intracranial tumor, occurring most frequently in adults, showing a wide variety of growth patterns. (scielo.br)
  • BACKGROUND: The concurrent diagnosis of meningioma with increased intracranial pressure has not been reported previously in a patient who meets diagnostic criteria for multiple chemical sensitivities (MCS). (cdc.gov)
  • Those who evaluate patients with MCS are reminded that meningiomas and other intracranial mass lesions can affect olfaction, and that patients with MCS can have treatable intracranial abnormalities. (cdc.gov)
  • Intraventricular meningiomas are rare tumors, comprising only 0.5% to 5% of all intracranial meningiomas. (mendeley.com)
  • Meningiomas account for over a third of all primary CNS tumors diagnosed in the United States, with ~18,000 new cases diagnosed annually and a prevalence of 97.5/100,000 individuals, making them the most common primary intracranial neoplasms in adults ( 2 , 3 ). (frontiersin.org)
  • This colour enhanced coronal (frontal) MRI view of the brain shows a benign intracranial tumor called a meningioma (red). (sciencephoto.com)
  • Meningioma is the most common intracranial tumor, and recent studies have drawn attention to the importance of further research on malignant meningioma. (frontiersin.org)
  • Meningiomas, tumors of the meningeal coverings of the brain and spinal cord, are the most common intracranial tumors. (frontiersin.org)
  • Meningioma, also known as meningeal tumor, is typically a slow-growing tumor that forms from the meninges, the membranous layers surrounding the brain and spinal cord. (wikipedia.org)
  • Malignant meningioma is a rare, fast-growing tumor that forms in one of the inner layers of the meninges (thin layers of tissue that cover and protect the brain and spinal cord). (wikipedia.org)
  • A woman writes in to get advice for her friend, recently diagnosed with a meningioma, or brain tumour (in this case, a tumour of the protective membranes around the brain and spinal cord). (healthy.net)
  • Meningiomas make up nearly a quarter (25%) of all primary brain and spinal cord tumours in adults in the UK. (macmillan.org.uk)
  • Meningiomas start in the cells of the membranes that cover the brain and spinal cord (meninges). (cancer.ca)
  • A meningioma is a tumor that arises from the meninges - the membranes that surround your brain and spinal cord. (mayoclinic.org)
  • Meningioma starts in the meningeal tissues, which are thin membranes that surround the brain and spinal cord. (cancer.net)
  • Spinal meningioma usually occurs in the spine at chest level and may push against the spinal cord. (cancer.net)
  • A meningioma is a common type of tumor that can develop in the tissues that cover the brain or spinal cord. (moffitt.org)
  • The meninges, tissues that cover the brain and spinal cord, are the place that certain tumors called meningiomas are found. (clevelandclinic.org)
  • A meningioma is a type of tumor that develops from the meninges, the membrane that surrounds the brain and spinal cord. (sbwire.com)
  • A meningioma can cause symptoms by pressing on the brain or spinal cord. (sbwire.com)
  • A meningioma is a tumor that develops out of the protective membranes called meninges which surround the brain and spinal cord, states Mayfield Clinic for Brain and Spine. (reference.com)
  • Johns Hopkins researchers say they have discovered one of the most important cellular mechanisms driving the growth and progression of meningioma, the most common form of brain and spinal cord tumor. (news-medical.net)
  • The national support group founded and run by meningioma patients for everyone affected by a meningeal tumour(s) of the brain or spinal cord. (bt.com)
  • Meningiomas are usually benign tumors of the lining of the brain and spinal cord. (ancestralfindings.com)
  • Meningiomas are tumors in the membranes that surround the brain and spinal cord. (nyp.org)
  • While we do not know what causes posterior fossa meningiomas, these tumors are often benign and slow-growing, arising from the meninges, or layers of tissue that cover the brain and spinal cord. (mountsinai.org)
  • Posterior fossa meningiomas can press on the brain, spinal cord, and the nerves surrounding them. (mountsinai.org)
  • Meningioma is a tumor that forms in the meninges around the brain and rarely in the region of the spinal cord. (apollohospitals.com)
  • Most people with a meningioma will have a tumor at only one site, but it also is possible to have several tumors growing simultaneously in different parts of the brain and spinal cord. (brighamandwomens.org)
  • A meningioma is a type of tumor that grows in the meninges, which are layers of tissue that cover the brain and spinal cord. (vidanthealth.com)
  • Meningioma tumors grow in the layers of tissue that cover the brain and spinal cord. (spectrumhealth.org)
  • The national support group founded and run by meningioma patients for everyone affected by a meningeal tumours of the brain or spinal cord.Founded in 1999 and dedicated to helping everyone affected by meningioma, we offer free support and clear jargon-free information. (nochex.com)
  • A meningioma is a tumor that arises in the meninges - the thin membranes that cover and provide a protective wrapping for your brain and spinal cord. (aurorahealthcare.org)
  • Meningiomas are slow-growing tumors in membranes (meninges) that cover the surface of the brain, spinal cord, or spinal nerve root. (spectrumhealth.org)
  • Almost all meningiomas are benign (not cancerous), but they still cause problems because they press on the brain or spinal cord. (spectrumhealth.org)
  • Meningiomas are caused by abnormal growth of cells on surface coverings of the brain, spinal cord, or spinal nerve roots. (spectrumhealth.org)
  • In fact, meningioma tumors -- slow-growing tumors that arise from the membrane surrounding the brain and spinal cord -- are the most common cause of seizures in dogs over 7 years of age. (petcarerx.com)
  • A meningioma is a tumour that starts in the meninges. (macmillan.org.uk)
  • Meningiomas are tumors that originate in the meninges, which are the outer three layers of tissue between the skull and the brain that cover and protect the brain just under the skull. (hopkinsmedicine.org)
  • The middle layer of the meninges, called the arachnoid, is where meningiomas form. (hopkinsmedicine.org)
  • Doctors know that something alters some cells in your meninges to make them multiply out of control, leading to a meningioma tumor. (mayoclinic.org)
  • Occasionally cells in the meninges will reproduce abnormally and a tumor, called a meningioma, will develop. (wisegeek.com)
  • Calcium deposits would be different from a benign tumor on the meninges, or lining of the brain, a tumor which is known as a meningioma. (medhelp.org)
  • There are a number of approaches to meningioma surgery for tumors growing on the meninges of the brain. (wisegeek.com)
  • Meningiomas grow from the meninges. (cureresearch.com)
  • Intraventricular meningiomas form in the part of the brain that produces and distributes spinal fluid. (stanford.edu)
  • Intraventricular meningioma. (cancer.net)
  • Intraventricular meningioma occurs in the chambers that carry fluid throughout the brain. (cancer.net)
  • A 45-year-old woman who had surgery six years prior for an intraventricular meningioma developed progressive headaches and numbness on the left side of her body. (upmc.com)
  • Post-surgical scan shows the successful removal of the intraventricular meningioma. (upmc.com)
  • In this article, 8 cases of histopathologically proven intraventricular meningioma that were treated at the Çukurova University Neurosurgery Department are discussed. (mendeley.com)
  • The authors present a case of intraventricular malignant meningioma located in the frontal horn of lateral ventricle and extended into the third ventricle in a 39-year-old man. (koreamed.org)
  • Anaplastic or malignant meningiomas are high-grade (grade 3) tumours. (cancer.ca)
  • One hundred fifteen patients with cavernous sinus meningiomas, excluding atypical or malignant meningiomas, were treated with GKS between 1991 and 2003. (thejns.org)
  • (14) , using two chromosome 10p markers ( D10S674 and D10S89 ) and four chromosome 10q markers ( ZNF22, D10S676, D10S677 , and D10S169 ), found LOH for combined 10q loci in 3 of 56 (5.4%) benign, 4 of 10 (40%) atypical, and 5 of 9 (55.6%) malignant meningiomas. (aacrjournals.org)
  • Both PC10 and 19A2 labelling indices (LI) showed a significant difference between benign and malignant meningiomas. (nih.gov)
  • Ninety-two percent of meningiomas are benign. (wikipedia.org)
  • About 85 percent of meningiomas are benign and most can be removed with surgery. (hopkinsmedicine.org)
  • Since ninety percent of meningiomas are benign, chemotherapy has not been found to be useful. (ancestralfindings.com)
  • Abstract 71: Meningioma: response to retinoids and radiation therapy. (aacrjournals.org)
  • Additionally, they attempted to add to previous characterizations of the epidemiology of primary meningiomas and assess the effectiveness of the standard of care for benign and anaplastic meningiomas. (medscape.com)
  • They also sought to characterize the efficacy of various treatment options in atypical and anaplastic meningiomas separately since nearly all other analyses have grouped these two together despite varying treatment regimens for these behavior categories. (medscape.com)
  • SEER data from 1973 to 2015 were queried using appropriate ICD-O-3 codes for benign, atypical, and anaplastic meningiomas. (medscape.com)
  • Previous epidemiological studies have shown that benign meningiomas represent approximately 94% of all meningioma cases, whereas atypical and anaplastic meningiomas account for about 4% and 1%, respectively. (medscape.com)
  • [ 5 ] Atypical and anaplastic meningiomas have lower survival rates and are often associated with recurrence. (medscape.com)
  • Anaplastic meningiomas often shed most of the obvious features of meningiomas, and their diagnosis may be difficult. (medscape.com)
  • In general, atypical meningiomas and anaplastic meningiomas comprise less than 10% of all meningiomas. (medscape.com)
  • Atypical and anaplastic meningiomas, however, show a male predominance. (medscape.com)
  • 1986-2004) PMID 17766430 -- "Atypical and anaplastic meningiomas: prognostic implication of clinicopathological features. (wikibooks.org)
  • The recurrence rate of atypical and anaplastic meningiomas is the highest. (ucdenver.edu)
  • The majority of meningiomas are benign and grow slowly over time, but some may be cancerous. (reference.com)
  • The majority of meningiomas are benign and grow very slowly. (ucdenver.edu)
  • While the vast majority of meningiomas are benign, they can also be atypical (seven to eight percent) or anaplastic /malignant (two to three percent). (ancestralfindings.com)
  • Falx and parasagittal meningioma. (cancer.net)
  • Parasagittal meningioma occurs at the top of the falx just on the inside of the skull. (cancer.net)
  • The aim of this study was to evaluate the outcomes in patients with convexity, parasagittal, or falcine meningiomas treated using Gamma Knife surgery (GKS) and to determine management strategy considering a risk of radiation-induced edema. (thejns.org)
  • One hundred twelve patients who harbored 125 convexity, parasagittal, or falcine meningiomas were assessed. (thejns.org)
  • Gamma Knife surgery is an effective treatment for convexity, parasagittal, and falcine meningiomas as the initial or adjuvant treatment. (thejns.org)
  • However, GKS should be restricted to small- to medium-sized tumors, particularly in patients with primary tumors, because radiation-induced edema is more common in convexity, parasagittal, and falcine meningiomas than skull base meningiomas. (thejns.org)
  • We present the unique case of an extraaxial, dural-based ependymoma without parenchymal involvement that was radiographically identical to a parasagittal, falcine meningioma. (ajnr.org)
  • The parasagittal location is a typical one for meningiomas. (merckmanuals.com)
  • Large parasagittal meningiomas may result in bilateral leg weakness. (brighamandwomens.org)
  • Meningiomas also may occur as a spinal tumor, more often in women than in men. (wikipedia.org)
  • Meningiomas occur more commonly in women and are often discovered at older ages, but may occur at any age. (mayoclinic.org)
  • There is no solid evidence to support the assertion that meningiomas occur in association with cellphone use. (mayoclinic.org)
  • [ 7 ] Childhood meningiomas occur more often in males. (medscape.com)
  • [ 8 , 9 ] Meningiomas associated with neurofibromatosis type 2 (NF2) tend to occur in younger individuals and with equal distribution between males and females. (medscape.com)
  • With the exception that papillary meningiomas are more common in children, meningiomas are rather uncommon in children and almost never occur in infants. (medscape.com)
  • Symptoms that occur due to meningiomas depend on their location and how much pressure they exert on the brain. (ucdenver.edu)
  • Meningioma can occur between 30 and 70 years of age. (apollohospitals.com)
  • When multiple meningiomas occur, more than one type of treatment may be necessary. (brighamandwomens.org)
  • Meningiomas are the most common type of brain tumors in adults and occur more often than cancerous brain tumors. (vidanthealth.com)
  • Meningiomas occur nearly twice as often in women as in men, the most common age at time of diagnosis being 45. (spectrumhealth.org)
  • The vast majority of meningiomas occur in dogs over 7 years-old and cats over 10 years-old . (petcarerx.com)
  • In addition, because most meningiomas in dogs occur in the front of the skull where olfactory lobes are located, their sense of smell may be affected. (petcarerx.com)
  • The classic monograph on meningiomas by Cushing and Eisenhardt presents nine major types and twenty subtypes. (scielo.br)
  • The research has led to a discovery, as Meléndez explained: 'Expression analyses allowed us to identify that meningiomas can be classified into an aggressive and a non-aggressive group - despite WHO classification criteria establishing three malignancy groups and about 15 histopathological subtypes. (scientific-computing.com)
  • Meningiomas were originally classified into 9 major subtypes based on their structure and form. (brighamandwomens.org)
  • According to the World Health Organization (WHO) grading, meningioma is classified into 15 subtypes with three grades of malignancy. (frontiersin.org)
  • In many cases, because meningiomas do not cause any noticeable signs or symptoms, they are only discovered as a result of imaging scans done for reasons that turn out to be unrelated to the tumor, such as a head injury, stroke or headaches. (mayoclinic.org)
  • When symptoms do develop they may vary depending on the location and size of the meningioma and include headaches, vision changes and difficulty hearing. (wisegeek.com)
  • A meningioma is a brain tumor originating in the membranous layers around the brain that, depending on its location, may cause headaches, vision problems, vomiting, seizures, or changes in behavior or personality, according to the National Cancer Institute. (reference.com)
  • The symptoms of a brain meningioma include headaches, blurred vision, arm and leg weakness, numbness and seizures, according to Johns Hopkins Medicine. (reference.com)
  • Meningiomas may cause seizures, headaches, and focal neurological defects, such as arm or leg weakness, or vision loss. (brighamandwomens.org)
  • Symptoms of a convexity meningioma are seizures, focal neurological deficits, or headaches. (brighamandwomens.org)
  • Describe the advantages and disadvantages of this technique for diagnosis of meningioma. (clinicaladvisor.com)
  • V. Describe the advantages and disadvantages of the alternative techniques for diagnosis of meningioma. (clinicaladvisor.com)
  • The patient subsequently underwent transcranial surgery with a final diagnosis of meningioma. (nih.gov)
  • Directed by Dr. Chetan Bettegowda, the team at the Johns Hopkins Meningioma Center works together to provide the safest and most effective treatment possible for patients with meningioma. (hopkinsmedicine.org)
  • Most patients with meningioma undergo surgery to remove the tumor and a small amount of surrounding healthy tissue. (moffitt.org)
  • We currently have multiple clinical trials at Stanford evaluating new medical approaches, devices, drugs, or other treatments for meningiomas that are recruiting participants. (stanford.edu)
  • You will learn about the different treatments doctors use for people with meningioma. (cancer.net)
  • Chemotherapy and radiation therapy are also common treatments for meningioma. (moffitt.org)
  • What treatments are available for meningioma? (reference.com)
  • Surgery, radiation treatments and drugs treat meningiomas, states Mayo Clinic. (reference.com)
  • Various information is available about treatments available for Meningioma , or research treatments for other diseases. (cureresearch.com)
  • Radiation may be used to treat meningiomas in locations that are difficult to reach by surgery. (hopkinsmedicine.org)
  • There are many other ways besides surgery to treat meningiomas - Cyberknife radiation (which does not use a knife), gamma knife, Novalis, IMRT. (medhelp.org)
  • This type makes up less than 10% of all meningiomas. (cancer.net)
  • It accounts for less than 10% of meningiomas. (cancer.net)
  • [ 6 ] Patients with multiple meningiomas generally comprise less than 10% of cases. (medscape.com)
  • The recurrence rate of posterior fossa meningiomas is less than 10 percent after tumor resection (removal). (mountsinai.org)
  • Hollywood stunt woman, Jill Brown, was diagnosed with a benign convexity meningioma brain tumor and searched for the right doctor and medical team across the country. (hopkinsmedicine.org)
  • Hollywood stunt woman Jill Brown received an incidental diagnosis of a benign convexity meningioma brain tumor after a stunt went awry. (hopkinsmedicine.org)
  • More specifically, the authors aimed to answer the question of whether adjuvant radiotherapy following resection of atypical meningioma confers a cause-specific survival benefit. (medscape.com)
  • In benign meningiomas, gross-total resection (HR 0.289, p = 0.013) imparted a significant cause-specific survival benefit over no treatment. (medscape.com)
  • In anaplastic meningioma cases, adjuvant radiotherapy imparted a significant survival benefit following both subtotal (HR 0.089, p = 0.018) and gross-total (HR 0.162, p = 0.002) resection as compared to gross-total resection alone. (medscape.com)
  • The results of this study demonstrate that the role of adjuvant radiotherapy, especially after the resection of atypical meningioma, remains somewhat unclear. (medscape.com)
  • Hyperbaric therapy is effective in reducing edema formation and neurological deficits after resection of meningiomas. (greenmedinfo.com)
  • Cavernous sinus meningioma represent a scenario where SRS is particularly useful given the potential morbidity of surgical resection in that region. (wikibooks.org)
  • Patients with vestibular schwannoma and/or meningioma diagnosed by MRI where surgical resection has been selected as treatment. (masseyeandear.org)
  • Most meningiomas are effectively addressed by surgical resection. (aacrjournals.org)
  • Atomic bomb survivors from Hiroshima had a higher than typical frequency of developing meningiomas, with the incidence increasing the closer that they were to the site of the explosion. (wikipedia.org)
  • [ 21 ] An increase in cranial imaging for a variety of medical indications has led to a greater reported incidence of primary meningioma in patients who were not originally being assessed for meningioma. (medscape.com)
  • From 2004 to 2010, there were 7,148 newly diagnosed cases of spinal meningioma (age adjusted incidence, 0.33/100,000 population). (medscape.com)
  • The overall incidence of meningioma in Norway is 1.5 per 100,000 population among men and 2.8 in women. (medscape.com)
  • Meningioma is essentially a tumor of adulthood, with a peak incidence in the sixth decade of life. (medscape.com)
  • This would also explain the high incidence of meningiomas around the sagittal sinus, which has a high concentration of meningothelial cells. (medscape.com)
  • Rising trends in incidence were also seen for meningioma in the total male population. (greenmedinfo.com)
  • This study aimed to investigate the incidence of meningioma in relation to hormonal contraceptive exposure in Indonesia. (ingentaconnect.com)
  • PCI increases incidence of meningioma by 10X baseline rate. (wikibooks.org)
  • The aim of this study was to illustrate the demographic characteristics of meningioma patients and observe the effect of adjuvant radiation therapy on survival by using the Surveillance, Epidemiology, and End Results (SEER) database. (medscape.com)
  • CyberKnife was invented at Stanford and treats a variety of conditions, including meningiomas, with high-dose radiation therapy. (stanford.edu)
  • Radiation therapy that involves radiation to the head may increase the risk of a meningioma. (mayoclinic.org)
  • Descriptions of the most common treatment options for meningioma are listed below, including surgery, radiation therapy, and very rarely, chemotherapy. (cancer.net)
  • In this study, the authors evaluated the outcomes of parasellar and sellar meningiomas managed with Gamma Knife radiosurgery (GKRS) both as an adjunct to microsurgical removal or conventional radiation therapy and as a primary treatment modality. (thejns.org)
  • There are several types of meningioma treatment, which range from chemotherapy and radiation therapy to traditional surgery and minimally invasive procedures. (moffitt.org)
  • One example is stereotactic radiosurgery, a highly precise type of radiation therapy that is often used for meningioma treatment. (moffitt.org)
  • Radiation therapy recommended for portions of a meningioma that could not be removed with surgery and continues to grow or recurrent meningiomas, especially if they are atypical or anaplastic. (ucdenver.edu)
  • Some meningiomas respond best to radiation therapy alone, including highly precise stereotactic radiosurgery. (nyp.org)
  • Even if the tumor is completely removed during surgery, some doctors may still recommend radiation therapy to help prevent another meningioma from developing in the future. (vidanthealth.com)
  • However unresectable, partially resected, recurrent and high grade meningiomas are also typically treated with adjuvant or definitive radiation therapy. (aacrjournals.org)
  • Some clinical trials in Canada are open to people with meningioma. (cancer.ca)
  • Thus, given these results, prospective randomized clinical studies are warranted to provide clear information on the effects of adjuvant radiation in meningioma treatment. (medscape.com)
  • The Stanford Meningioma Program combines a multidisciplinary clinical care team with a strong clinical and research program, in an effort to facilitate the rapid transfer of basic scientific findings into clinical protocols for patients with tumors of the brain, including meningiomas. (stanford.edu)
  • Genomic features of meningioma further associate with tumor location, histologic subtype, and possibly clinical behavior. (frontiersin.org)
  • With two major academic medical centers - Columbia University Medical Center and Weill Cornell Medicine - we lead and participate in clinical trials of new therapies for meningiomas. (nyp.org)
  • Intraosseous meningiomas often display clinical and radiologic features that can be confused for fibrous dysplasia. (omicsonline.org)
  • We also propose that a methylation-based meningioma classification could provide clues in the assessment of individual risk of meningioma recurrence, which is associated with clinical benefits for patients. (frontiersin.org)
  • Meningiomas have a wide range of biological potential and clinical behaviour. (nih.gov)
  • People with neurofibromatosis type 2 (NF-2) have a 50% chance of developing one or more meningiomas. (wikipedia.org)
  • The most frequent genetic mutations (~50%) involved in meningiomas are inactivation mutations in the neurofibromatosis 2 gene (merlin) on chromosome 22q. (wikipedia.org)
  • Sometimes meningioma runs in families, especially in people with neurofibromatosis . (cancer.ca)
  • The rare disorder neurofibromatosis 2 increases the risk of meningioma and other brain tumors. (mayoclinic.org)
  • Antinheimo J, Sankila R, Carpen O, Pukkala E, Sainio M, Jaaskelainen J (2000) Population-based analysis of sporadic and type 2 neurofibromatosis-associated meningiomas and schwannomas. (springer.com)
  • Evans DG, Blair V, Strachan T, Lye RH, Ramsden RT (1995) Variation of expression of the gene for type 2 neurofibromatosis: absence of a gender effect on vestibular schwannomas, but confirmation of a preponderance of meningiomas in females. (springer.com)
  • Goutagny S, Kalamarides M (2010) Meningiomas and neurofibromatosis. (springer.com)
  • A mutation on the neurofibromatosis type 2 gene usually results in a meningioma in the cerebellar and cerebral hemispheres. (ancestralfindings.com)
  • The recurrence rate for partially removed meningiomas is higher. (ucdenver.edu)
  • Dr Bárbara Meléndez and her colleagues in the Unidad de Investigación de Patología Molecular (Molecular Pathology Research Unit) at Hospital Virgen de la Salud in Toledo, Spain, are using Qlucore Omics Explorer to investigate how generally benign meningiomas can start to exhibit the sort of histology and recurrence usually associated with more aggressive tumours. (scientific-computing.com)
  • The DNA methylation-based meningioma classification published in 2017 used DNA copy number analysis, mutation profiling, and RNA sequencing to distinguish six clinically relevant methylation classes, which contributed to a better prediction of tumor recurrence and prognosis. (frontiersin.org)
  • Although the WHO grade is considered to be the most reliable indicator in predicting meningioma prognosis ( 2 , 3 ), there is significant variation with regards to the risk of recurrence for individual patients ( 4 , 5 ). (frontiersin.org)
  • Recurrence of meningiomas versus proliferating cell nuclear antigen (PCNA) positivity and AgNOR counting. (nih.gov)
  • Chordoid meningioma, which is assigned to WHO grade II (atypical meningioma), is a rare meningioma that is sometimes associated with Castleman syndrome and characterized by fever of unknown origin, hematological abnormalities (eg, hypochromic or microcytic anemia), and dysgammaglobulinemia, with bone marrow plasmacytosis. (nature.com)
  • Christiaans I, Kenter SB, Brink HC, van Os TA, Baas F, van den Munckhof P, Kidd AM, Hulsebos TJ (2010) Germline SMARCB1 mutation and somatic NF2 mutations in familial multiple meningiomas. (springer.com)
  • Evans DG, Watson C, King A, Wallace AJ, Baser ME (2005) Multiple meningiomas: differential involvement of the NF2 gene in children and adults. (springer.com)
  • Meningiomas often are considered benign tumors that can be removed by surgery, but most recurrent meningiomas correspond to histologic benign tumors. (wikipedia.org)
  • Recurrent meningiomas are any meningiomas that return after treatment. (stanford.edu)
  • She survived four subsequent brain surgeries for recurrent meningiomas, the latest in April 2015. (braintumor.org)
  • 18% cases of meningothelial meningioma whereas studies by Rohringer et al. (thefreedictionary.com)
  • In the histopathological analysis of the present case, no areas of necrosis or thrombosis or vessel thrombosis were observed and, following the immunohistochemical analysis, the diagnosis of meningothelial meningioma was confirmed. (thefreedictionary.com)
  • Histopathology revealed meningothelial meningioma (WHO grade 1). (thefreedictionary.com)
  • En plaque meningiomas characteristically lead to slowly increasing proptosis with the eye angled downward. (wikipedia.org)
  • Most all meningiomas grow very slowly and almost never metastasize to other parts of the body. (wikipedia.org)
  • Meningiomas usually grow slowly. (macmillan.org.uk)
  • Most meningiomas grow very slowly, often over many years without causing symptoms. (mayoclinic.org)
  • Because most meningiomas grow slowly, often without any significant signs and symptoms, they do not always require immediate treatment and may be monitored over time. (mayoclinic.org)
  • Most signs and symptoms of a meningioma evolve slowly, but sometimes a meningioma requires emergency care. (mayoclinic.org)
  • Because a grade I meningioma grows slowly, active surveillance may be recommended for some patients. (cancer.net)
  • Though meningiomas account for about a third of all brain tumors, they are not always discovered right away because they grow very slowly. (mountsinai.org)
  • You may not have any symptoms because meningiomas can grow slowly and do not interfere with brain function right away. (mountsinai.org)
  • In many cases, benign meningiomas grow slowly. (brighamandwomens.org)
  • In many people, meningiomas don't cause any symptoms and grow quite slowly. (vidanthealth.com)
  • Approximately 95% of spinal meningiomas are noncancerous (benign), and they generally grow very slowly. (aurorahealthcare.org)
  • Meningiomas are a common primary brain tumour in adults. (cancer.ca)
  • Meningioma is the most common type of primary brain tumor, accounting for about 30 percent of all brain tumors. (hopkinsmedicine.org)
  • Meningioma comprises about one fourth of all primary tumors of the central nervous system (CNS). (medscape.com)
  • Vlychou M et al (2016) Primary intraosseous meningioma: an osteosclerotic bone tumour mimicking malignancy. (springer.com)
  • Lee SJ et al (2015) Primary intraosseous meningioma in the orbital bony wall: a case report and review of the literature review. (springer.com)
  • Elder JB et al (2007) Primary intraosseous meningioma. (springer.com)
  • Lang FF et al (2000) Primary extradural meningiomas: a report on nine cased and review of the literature from the era of computerized tomography scanning. (springer.com)
  • Patients must have a histologically documented primary, recurrent or residual meningioma which is unresectable. (clinicaltrials.gov)
  • Meningiomas account for about one-third of all primary brain tumors. (clevelandclinic.org)
  • Meningiomas range from 13 to 19 per cent of all primary brain tumors 1 . (scielo.br)
  • Hormonal contraceptive has been related to risk for meningioma, a primary brain tumor occurred 2-3 times higher in female than male. (ingentaconnect.com)
  • A World Health Organization grade-1 meningioma, the primary cell of which has round to ovoid, occasionally large and pleomorphic nuclei, pale eosinophilic cytoplasm, and numerous vacuoles to small cysts. (thefreedictionary.com)
  • There are no established measures for the primary prevention of meningioma. (wikidoc.org)
  • Primary intraorbital meningioma. (bmj.com)
  • Meningiomas account for about 27 percent of primary brain tumors, making them the most common of that type. (brighamandwomens.org)
  • Here, we show that the majority of primary (de novo) atypical meningiomas display loss of NF2, which co-occurs either with genomic instability or recurrent SMARCB1 mutations. (mit.edu)
  • Importantly, these primary atypical meningiomas do not harbour TERT promoter mutations, which have been reported in atypical tumours that progressed from benign ones. (mit.edu)
  • Our results establish the genomic landscape of primary atypical meningiomas and potential therapeutic targets. (mit.edu)
  • Meningioma represents one third of all primary central nervous system neoplasms. (aacrjournals.org)
  • MTM announced she has a meningioma, the most common type of primary brain tumor. (readthehook.com)
  • Most meningiomas are slow growing tumours, although some can be faster growing. (macmillan.org.uk)
  • Most meningiomas are slow growing tumours. (macmillan.org.uk)
  • Benign meningiomas are low-grade (grade 1) tumours that account for approximately 70%-80% of all meningiomas. (cancer.ca)
  • Atypical or invasive meningiomas are low-grade (grade 2) tumours, but they grow faster than benign meningiomas and may spread to nearby tissue. (cancer.ca)
  • We stand for greater awareness of meningioma tumours, for prompt diagnosis, and quality care for all. (bt.com)
  • Meningiomas are mostly benign brain tumours, with a potential for becoming atypical or malignant. (mit.edu)
  • Meningioma is among the most frequent brain tumours predominantly affecting elderly women. (lu.se)
  • In one series, less than one-third of clinoidal meningiomas could be completely resected without unacceptable risk of damaging of blood vessels (especially the carotid artery) or cranial nerves, risks that are lower with radiosurgery. (wikipedia.org)
  • Recurrent Disease, as defined by the reappearance of a previously completely resected meningioma, within the past two years. (clinicaltrials.gov)
  • The differential diagnosis for sphenoid wing meningioma includes other types of tumors such as optic nerve sheath meningioma, cranial osteosarcoma, metastases, and also sarcoidosis. (wikipedia.org)
  • Suprasellar meningiomas originate in the base of the skull near the pituitary gland and optic nerve. (stanford.edu)
  • Optic nerve meningioma. (aao.org)
  • After an MRI and other tests, I got my diagnosis -- meningioma, a noncancerous tumor, on my optic nerve. (mdanderson.org)
  • We report a case of recurrent proptosis and optic neuropathy, initially misdiagnosed at an outside institution as fibrous dysplasia which ultimately revealed intraosseous meningioma. (omicsonline.org)
  • Meningiomas of the tuberculum sellae can induce compression of the optic tract. (nih.gov)
  • Similarly, meningiomas growing on the optic nerve can cause visual problems, including loss of patches within your field of vision, or even blindness. (brighamandwomens.org)
  • Treatment of sphenoid wing meningiomas often depends on the location and size of the tumor. (wikipedia.org)
  • A total of 57,998 patients were included in the analysis of demographic, meningioma, and treatment characteristics. (medscape.com)
  • While they often do not cause problems, some meningiomas do require treatment. (stanford.edu)
  • Join us to learn about the latest treatment options, network with other meningioma patients, and find encouragement and support. (stanford.edu)
  • A meningioma may not need immediate treatment and can often remain undetected for many years. (hopkinsmedicine.org)
  • Why choose Johns Hopkins for treatment of meningioma? (hopkinsmedicine.org)
  • The Johns Hopkins Meningioma Center offers patients individualized treatment plans including expert surgery. (hopkinsmedicine.org)
  • Patients who turn to Moffitt's Neuro-Oncology Program for meningioma treatment can work with some of the most experienced and knowledgeable medical professionals in the field, while benefitting from our relentless commitment to continually improving the meningioma survival rate. (moffitt.org)
  • Your care plan may also include treatment for symptoms and side effects, an important part of care for meningioma. (cancer.net)
  • For meningioma, it is the most common treatment. (cancer.net)
  • Even if a meningioma is not cancerous, it may require treatment. (wisegeek.com)
  • Recovery from a meningioma and its treatment may depend on the overall health of the patient, size of the tumor and the patient's age. (wisegeek.com)
  • As a result, patients who are diagnosed with meningioma often undergo treatment to shrink their tumor, alleviate symptoms and restore as much brain function as possible. (moffitt.org)
  • At Moffitt, our experienced surgeons specialize in minimally invasive and robotic procedures for brain cancer treatment and perform a high volume of these complex meningioma surgeries each year. (moffitt.org)
  • Patients who turn to Moffitt for meningioma treatment can access all of these treatment services in a single, convenient location. (moffitt.org)
  • To learn more about our approach to meningioma treatment, or to schedule an appointment with one of our oncologists who specializes in treating brain cancer, call 1-888-MOFFITT or submit a new patient registration form online. (moffitt.org)
  • Gamma Knife surgery is a safe and effective treatment over the long term in selected patients with cavernous sinus meningiomas. (thejns.org)
  • To compare daily oral mifepristone vs placebo with respect to time to treatment failure in patients with unresectable meningioma. (clinicaltrials.gov)
  • What Are the Meningioma Treatment Options? (moffitt.org)
  • Some people need only one form of meningioma treatment, while others require a combination of several therapies. (moffitt.org)
  • Whether you've just been diagnosed with meningioma or have completed several rounds of treatment, you can consult with the multispecialty team in our Neuro-Oncology Program with or without a physician's referral. (moffitt.org)
  • The findings, presented at the Radiological Society of North America's annual meeting, led researchers to conclude that Ga-68 DOTATATE may help guide post-treatment meningioma evaluations. (smartbrief.com)
  • Treatment of tinea capitis with radiation is classic scenario of radiation induced meningioma. (wikibooks.org)
  • Median interval between radiation treatment and development of meningioma is ~20 yrs. (wikibooks.org)
  • Surgery: The treatment of choice for meningiomas that cause symptoms is surgical removal. (ucdenver.edu)
  • The choice of your treatment depends upon the characteristics of your meningioma, its location, and your symptoms. (nyp.org)
  • While generally not used to treat most meningiomas, chemotherapy may become part of your treatment if your tumor is malignant or comes back after surgery. (nyp.org)
  • With extensive experience in diagnosing and evaluating meningiomas, our neurosurgeons can recommend the best comprehensive treatment plan for you. (mountsinai.org)
  • The Mount Sinai Health System is a major referral destination for diagnosis and treatment of posterior fossa and other types of meningiomas. (mountsinai.org)
  • Meningioma treatment may depend on different factors like the size of the tumor, overall health and the existing symptoms due to it. (apollohospitals.com)
  • Meningiomas vary in their symptoms and appropriate treatment options depending on where they are located. (brighamandwomens.org)
  • Surgery is the most common treatment for spinal meningiomas. (aurorahealthcare.org)
  • Some people with small, slow-growing meningiomas and no symptoms need no treatment but will be checked regularly with CT or MRI to monitor the growth of the tumor. (spectrumhealth.org)
  • Pretreatment of meningioma cell lines with ≤1μM doses of ATRA and 13CRA protected cells from radiation-induced cell death, while pre-treatment with fenretinide had no effect. (aacrjournals.org)
  • Treatment for a meningioma will ultimately depend on the size, location, and type of tumor. (petcarerx.com)
  • However, the currently available chemotherapy options do not work very well for meningioma. (cancer.net)
  • Chemotherapy - While chemotherapy medications are rarely used to treat meningioma, Moffitt's medical oncologists create individualized chemotherapy plans when appropriate. (moffitt.org)
  • Patients must not have received prior cytotoxic chemotherapy for meningioma. (clinicaltrials.gov)
  • Meningioma is the most common type of tumor that forms in the head. (mayoclinic.org)
  • Meningioma is usually a slow-growing tumor that forms on the surface of the brain. (cancer.net)
  • A sphenoid wing meningioma is a benign brain tumor near the sphenoid bone. (wikipedia.org)
  • Hussaini SM et al (2010) Intraosseous meningioma of the sphenoid bone. (springer.com)
  • Špero M. (2018) Intraosseous Meningioma (of the Greater Wing of the Sphenoid Bone). (springer.com)
  • Intraosseous meningiomas of the sphenoid bone are rare tumors that often present with proptosis and loss of vision. (omicsonline.org)
  • The cause of meningiomas is unknown, but research is being done to find out more. (macmillan.org.uk)
  • The underlying cause of meningiomas is not clear. (vidanthealth.com)
  • Meningioma tumors are classified based on the type of cells that are involved. (petcarerx.com)
  • Somatic mutations of the NF2 gene are found in the majority of both sporadic and NF2-associated meningiomas. (springer.com)
  • It is also possible that sporadic and NF2 disease-associated meningiomas arise as a result of different pathological mechanisms. (springer.com)
  • Next-generation sequencing has characterized recurrent somatic mutations in NF2, TRAF7, KLF4, AKT1, SMO , and PIK3CA , which are collectively present in ~80% of sporadic meningiomas. (frontiersin.org)
  • Most cases of meningioma are sporadic and random, while others seem to have a hereditary component. (ancestralfindings.com)
  • 1) Evaluate levels of phospho-Akt (p-AKT) and p16 INKA in subjects with NF2-related vestibular schwannomas (VS), sporadic VS, NF2-related meningiomas, and sporadic meningiomas after AR-42 has been taken per study protocol (40 mg every other day, 3 times per a week for 3 weeks preceding surgery). (masseyeandear.org)
  • 4) Perform NF2 gene sequencing (tumor and germ-line DNA) and Merlin protein expression in all VS and meningiomas and explore possible differences between sporadic and NF2-related tumors and baseline p-AKT activation and biological response to AR-42 based on NF2 mutational status and Merlin protein expression. (masseyeandear.org)
  • Meningiomas are a type of brain tumour . (macmillan.org.uk)
  • Benign meningiomas are the most common non-cancerous (benign) brain tumour and are found most often in people between the ages of 50 and 80. (cancer.ca)
  • Histologically, meningioma cells are relatively uniform, with a tendency to encircle one another, forming whorls and psammoma bodies (laminated calcific concretions). (wikipedia.org)
  • With all the above features, it is not difficult to imagine that some meningiomas can be true imposters, histologically mimicking other entities. (medscape.com)
  • Grade I meningiomas display a broad range of morphologic features and are considered histologically benign, with fewer than 4 mitoses/10 microscopic high-power fields (HPF). (frontiersin.org)
  • After surgery, this patient presented meningiomas which histologically, were of the meningothelial type. (osti.gov)
  • Meningiomas are the most common type of brain tumor, are typically benign, and may remain for years before they're identified by a doctor. (stanford.edu)
  • The meningioma is the most common type of brain tumor found in dogs and cats. (petcarerx.com)
  • Meningioma surgery to remove the tumor may have risks, such as infection and damage to other areas of the brain. (wisegeek.com)
  • Mutations in the TRAF7, KLF4, AKT1, and SMO genes are commonly expressed in benign skull-base meningiomas. (wikipedia.org)
  • [ 11 ] Overall, death from benign meningiomas is very low with exceptions for tumors in locations such as the skull base where the risk from tumor growth is greater. (medscape.com)
  • Skull-base meningiomas form in the bones in the bottom of the skull or in the boney ridge behind the eyes. (stanford.edu)
  • Sphenoid wing meningiomas form in the skull base behind the eyes. (stanford.edu)
  • Reasonable to consider observation for asymptomatic meningiomas, particularly in elderly patients or patients with skull-base (high operative risk) tumors. (wikibooks.org)
  • But when I looked online, I learned that MD Anderson treats both cancerous and non-cancerous skull base tumors like meningioma. (mdanderson.org)
  • Persons who have undergone radiation, especially to the scalp, are more at risk for developing meningiomas, as are those who have had a brain injury. (wikipedia.org)
  • Johns Hopkins' Meningioma Center is part of the Comprehensive Brain Tumor Center , one of the largest brain tumor centers in the world, with expertise in diagnosing and treating all types of brain tumors, including meningiomas. (hopkinsmedicine.org)
  • The meningioma survival rate is higher than that associated with most other types of brain tumors, primarily because meningiomas are usually noncancerous and slow to spread. (moffitt.org)
  • Signs and symptoms of a meningioma typically begin gradually and may be very subtle at first. (mayoclinic.org)
  • What Are the Symptoms of a Meningioma? (spectrumhealth.org)
  • The symptoms of a meningioma tumor will largely depend on the area of the brain involved. (petcarerx.com)
  • So most people with a meningioma walk around for years without knowing they have one. (readthehook.com)