A relatively common neoplasm of the CENTRAL NERVOUS SYSTEM that arises from arachnoidal cells. The majority are well differentiated vascular tumors which grow slowly and have a low potential to be invasive, although malignant subtypes occur. Meningiomas have a predilection to arise from the parasagittal region, cerebral convexity, sphenoidal ridge, olfactory groove, and SPINAL CANAL. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2056-7)
Benign and malignant neoplastic processes that arise from or secondarily involve the meningeal coverings of the brain and spinal cord.
A delicate membrane enveloping the brain and spinal cord. It lies between the PIA MATER and the DURA MATER. It is separated from the pia mater by the subarachnoid cavity which is filled with CEREBROSPINAL FLUID.
Neoplasms of the bony part of the skull.
Increase in the mass of bone per unit volume.
Neoplasms of the base of the skull specifically, differentiated from neoplasms of unspecified sites or bones of the skull (SKULL NEOPLASMS).
Junction between the cerebellum and the pons.
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
The outermost of the three MENINGES, a fibrous membrane of connective tissue that covers the brain and the spinal cord.
Tumor suppressor genes located on the long arm of human chromosome 22. Mutation or loss of these genes causes NEUROFIBROMATOSIS 2.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
A benign SCHWANNOMA of the eighth cranial nerve (VESTIBULOCOCHLEAR NERVE), mostly arising from the vestibular branch (VESTIBULAR NERVE) during the fifth or sixth decade of life. Clinical manifestations include HEARING LOSS; HEADACHE; VERTIGO; TINNITUS; and FACIAL PAIN. Bilateral acoustic neuromas are associated with NEUROFIBROMATOSIS 2. (From Adams et al., Principles of Neurology, 6th ed, p673)
Benign and malignant neoplasms that arise from the optic nerve or its sheath. OPTIC NERVE GLIOMA is the most common histologic type. Optic nerve neoplasms tend to cause unilateral visual loss and an afferent pupillary defect and may spread via neural pathways to the brain.
A tumor composed of spindle cells with a rich vascular network, which apparently arises from pericytes, cells of smooth muscle origin that lie around small vessels. Benign and malignant hemangiopericytomas exist, and the rarity of these lesions has led to considerable confusion in distinguishing between benign and malignant variants. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1364)
Surgery performed on the nervous system or its parts.
Tumors or cancer of any part of the hearing and equilibrium system of the body (the EXTERNAL EAR, the MIDDLE EAR, and the INNER EAR).
An autosomal dominant disorder characterized by a high incidence of bilateral acoustic neuromas as well as schwannomas (NEURILEMMOMA) of other cranial and peripheral nerves, and other benign intracranial tumors including meningiomas, ependymomas, spinal neurofibromas, and gliomas. The disease has been linked to mutations of the NF2 gene (GENES, NEUROFIBROMATOSIS 2) on chromosome 22 (22q12) and usually presents clinically in the first or second decade of life.
Any operation on the cranium or incision into the cranium. (Dorland, 28th ed)
Neoplasms located in the brain ventricles, including the two lateral, the third, and the fourth ventricle. Ventricular tumors may be primary (e.g., CHOROID PLEXUS NEOPLASMS and GLIOMA, SUBEPENDYMAL), metastasize from distant organs, or occur as extensions of locally invasive tumors from adjacent brain structures.
A neoplasm that arises from SCHWANN CELLS of the cranial, peripheral, and autonomic nerves. Clinically, these tumors may present as a cranial neuropathy, abdominal or soft tissue mass, intracranial lesion, or with spinal cord compression. Histologically, these tumors are encapsulated, highly vascular, and composed of a homogenous pattern of biphasic fusiform-shaped cells that may have a palisaded appearance. (From DeVita Jr et al., Cancer: Principles and Practice of Oncology, 5th ed, pp964-5)
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
The three membranes that cover the BRAIN and the SPINAL CORD. They are the dura mater, the arachnoid, and the pia mater.
The large hole at the base of the skull through which the SPINAL CORD passes.
A specific pair of GROUP G CHROMOSOMES of the human chromosome classification.
A membrane protein homologous to the ERM (Ezrin-Radixin-Moesin) family of cytoskeleton-associated proteins which regulate physical properties of membranes. Alterations in neurofibromin 2 are the cause of NEUROFIBROMATOSIS 2.
Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564)
The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.
A cylindrical column of tissue that lies within the vertebral canal. It is composed of WHITE MATTER and GRAY MATTER.
A surgical specialty concerned with the treatment of diseases and disorders of the brain, spinal cord, and peripheral and sympathetic nervous system.
The teaching staff and members of the administrative staff having academic rank in a medical school.

SPARC: a potential diagnostic marker of invasive meningiomas. (1/1193)

SPARC, a secreted, extracellular matrix-associated protein implicated in the modulation of cell adhesion and migration, was evaluated as a marker for invasive meningiomas. Although the majority of meningiomas are clinically and morphologically benign, approximately 10% progress into atypical and malignant tumors, according to the standard criteria. However, a subset of meningiomas presents as histomorphologically benign tumors (WHO grade I), but they are clinically invasive. It has been suggested that these tumors should be classified as malignant, and that the patients may require adjuvant therapy and closer follow up. Unfortunately, a significant number of these tumors may not be recognized because the surgical specimen used to assess the grade of a tumor lacks the infiltrative interface with the brain, which is currently necessary to determine its invasive character. Therefore, a marker of heightened invasiveness would greatly facilitate the identification of this subset of patients. In this study, the immunohistochemical expression of SPARC in benign, noninvasive primary meningiomas was compared with its expression in invasive, aggressive, primary and recurrent meningiomas. SPARC was not expressed in the 9 benign, noninvasive tumors, but was highly expressed in the 20 invasive tumors, regardless of the grade. The findings suggest that SPARC is a potential diagnostic marker of invasive meningiomas and is capable of distinguishing the histomorphologically benign noninvasive from the histomorphologically benign but invasive meningiomas, in the absence of the infiltrative interface.  (+info)

Hemangioblastoma mimicking tentorial meningioma: preoperative embolization of the meningeal arterial blood supply--case report. (2/1193)

A 72-year-old male presented with a primary hemangioblastoma of the posterior fossa with unusual dural attachment and meningeal arterial blood supply from the external carotid artery and marginal tentorial artery. Preoperative embolization facilitated complete resection of the tumor with no resultant neurological deficit. Hemangioblastoma must be included in the differential diagnosis of tumors with dural involvement. Preoperative embolization is very useful in such tumors.  (+info)

Cerebral veins: comparative study of CT venography with intraarterial digital subtraction angiography. (3/1193)

BACKGROUND AND PURPOSE: Our objective was to compare the reliability of CT venography with intraarterial digital subtraction angiography (DSA) in imaging cerebral venous anatomy and pathology. METHODS: In 25 consecutive patients, 426 venous structures were determined as present, partially present, or absent by three observers evaluating CT multiplanar reformatted (MPR) and maximum intensity projection (MIP) images. These results were compared with the results from intraarterial DSA and, in a second step, with the results of an intraobserver consensus. In addition, pathologic conditions were described. RESULTS: Using DSA as the standard of reference, MPR images had an overall sensitivity of 95% (specificity, 19%) and MIP images a sensitivity of 80% (specificity, 44%) in depicting the cerebral venous anatomy. On the basis of an intraobserver consensus including DSA, MPR, and MIP images (415 vessels present), the sensitivity/specificity was 95%/91% for MPR, 90%/100% for DSA, and 79%/91% for MIP images. MPR images were superior to DSA images in showing the cavernous sinus, the inferior sagittal sinus, and the basal vein of Rosenthal. Venous occlusive diseases were correctly recognized on both MPR and MIP images. Only DSA images provided reliable information of invasion of a sinus by an adjacent meningioma. CONCLUSION: CT venography proved to be a reliable method to depict the cerebral venous structures. MPR images were superior to MIP images.  (+info)

A new technique of surface anatomy MR scanning of the brain: its application to scalp incision planning. (4/1193)

BACKGROUND AND PURPOSE: Surface anatomy scanning (SAS) is an established technique for demonstrating the brain's surface. We describe our experience in applying SAS with superposition of MR venograms to preoperative scalp incision planning. METHODS: In 16 patients, scalp incision planning was done by placing a water-filled plastic tube at the intended incision site when we performed SAS using half-Fourier single-shot fast spin-echo sequences. Two-dimensional phase-contrast MR angiograms were obtained to demonstrate the cortical veins and then superimposed upon the SAS images. The added images were compared with surgical findings using a four-point grading scale (0 to 3, poor to excellent). RESULTS: In each case, neurosurgeons could easily reach the lesion. Surgical findings correlated well with MR angiogram-added SAS images, with an average score of 2.56. CONCLUSION: Our simple technique is a useful means of preoperatively determining brain surface anatomy and can be used to plan a scalp incision site.  (+info)

In vivo hydrogen-1 magnetic resonance spectroscopy study of human intracranial tumors. (5/1193)

OBJECTIVE: To investigate the metabolic changes, pathological state and histological types of intracranial tumors with hydrogen-1 magnetic resonance spectroscopy (H-1 MRS). METHODS: Thirteen patients with intracranial tumors were studied with localized proton magnetic resonance spectroscopy (H-1MRS), in vivo. All spectra were obtained with a 2.0 T whole body MR imaging system. RESULTS: All the spectra of these tumors exhibited high ratios of choline (Cho)/creatine (Cr) and Cho/N-acetyl aspartate (NAA), and histologically different tumors showed obvious variations in the metabolite ratios. Significant differences of Cho/Cr ratio were found between meningiomas and astrocytomas by statistical evaluation. The spectra obtained after operation were remarkably different from those before operation. CONCLUSION: H-1 MRS can serve as a non-invasive clinical test for therapeutic and prognostic uses for intracranial tumors.  (+info)

NF2 gene mutations and allelic status of 1p, 14q and 22q in sporadic meningiomas. (6/1193)

Formation of meningiomas and their progression to malignancy may be a multi-step process, implying accumulation of genetic mutations at specific loci. To determine the relationship between early NF2 gene inactivation and the molecular mechanisms that may contribute to meningioma tumor progression, we have performed deletion mapping analysis at chromosomes 1, 14 and 22 in a series of 81 sporadic meningiomas (54 grade I (typical), 25 grade II (atypical) and two grade III (anaplastic)), which were also studied for NF2 gene mutations. Single-strand conformational polymorphism analysis was used to identify 11 mutations in five of the eight exons of the NF2 gene studied. All 11 tumors displayed loss of heterozygosity (LOH) for chromosome 22 markers; this anomaly was also detected in 33 additional tumors. Twenty-nine and 23 cases were characterized by LOH at 1p and 14q, respectively, mostly corresponding to aggressive tumors that also generally displayed LOH 22. All three alterations were detected in association in seven grade II and two grade III meningiomas, corroborating the hypothesis that the formation of aggressive meningiomas follows a multi-step tumor progression model.  (+info)

Clinical features and outcomes in patients with non-acoustic cerebellopontine angle tumours. (7/1193)

OBJECTIVES: Non-acoustic tumours of the cerebellopontine angle differ from vestibular schwannomas in their prevalence, clinical features, operative management, and surgical outcome. These features were studied in patients presenting to the regional neuro-otological unit. METHODS: A retrospective analysis of clinical notes identified 42 patients with non-acoustic tumours of the cerebellopontine angle. Data were extracted regarding presenting clinical features, histopathological data after surgical resection, surgical morbidity and mortality, and clinical outcome (mean 32 months follow up). RESULTS: The study group comprised 25 meningiomas (60%), 12 epidermoid cysts/cholesteatomata (28%), and five other tumours. In patients with meningiomas, symptoms differed considerably from patients presenting with vestibular schwannomas. Cerebellar signs were present in 52% and hearing loss in only 68%. Twenty per cent of patients had hydrocephalus at the time of diagnosis. After surgical resection, normal facial nerve function was preserved in 75% of cases. In the epidermoid group, fifth, seventh, and eighth nerve deficits were present in 42%, 33%, and 66% respectively. There were no new postoperative facial palsies. There were two recurrences (17%) requiring reoperation. Overall, there were two perioperative deaths from pneumonia and meningitis. CONCLUSIONS: Patients with non-acoustic lesions of the cerebellopontine angle often present with different symptoms and signs from those found in patients with schwannomas. Hearing loss is less prevalent and cerebellar signs and facial paresis are more common as presenting features. Hydrocephalus is often present in patients presenting with cerebellopontine angle meningiomas. Non-acoustic tumours can usually be resected with facial nerve preservation.  (+info)

Role of p53 gene mutation in tumor aggressiveness of intracranial meningiomas. (8/1193)

The mutations that occur in the p53 tumor suppressor gene have been studied in various human malignant tumors. However, little is known about this gene in meningiomas. To investigate the relationship and frequency of p53 gene mutations, the p53 polymerase chain reaction-single stranded conformational polymorphism (PCR-SSCP) and immunohistochemical study were performed on the 41 intracranial meningiomas (21 benign, 11 atypical, and 9 malignant). The higher the p53 protein expression rate, the poorer the histologic grade (9.5%, 72.7%, and 88.9% in benign, atypical and malignant meningioma, respectively) (p=0.000). The p53 protein expression rate was higher in recurrent meningioma (71.4%) than in nonrecurrent meningioma (10.5%) (p=0.002). PCR-SSCP method was performed in positive p53 protein immunoreactivity cases. p53 gene mutation rate was higher in the atypical (62.5%) and malignant (25%) meningiomas than in the benign meningioma (0%) (p=0.232). Also, the rate was higher in recurrent menigioma (20%) than in nonrecurrent meningioma (0%) (o=0.495). Among five to eight exons of the p53 gene, the mutation was observed on exon 7 more frequently. In conclusion, p53 immunoreactivity and p53 gene mutation are closely correlated with histologic grade and histologic atypia of intracranial meningiomas. p53 gene mutation would be considered as a useful marker to detect the progression of intracranial meningiomas.  (+info)

Extracranial meningiomas are classified according to Hoye et al. [4]. Primary extracranial meningioma and secondary extracranial meningioma can be classified according to the presence or absence of an intracranial meningioma. Primary extracranial meningiomas are composed of two types: a tumor originating from arachnoid cells remaining in the nerve sheaths and a tumor occurring ectopically without connection to the cranium. Secondary extracranial meningiomas are classified as intracranial tumors directly escaping from the cranium and extracranial meningioma that has metastasized from an intracranial meningioma [6]. According to this classification, our case is classified as an ectopic primary extracranial meningioma.. Intradural meningioma is known to be associated with radiation, virus, head trauma, smoking, nitrate, and high cholesterol levels, but the cause of primary extracranial meningioma is not yet clear. Possible hypotheses are as follows: (1) migration of arachnoid cells along the ...
meningioma; Meningiomas, Multiple; Meningiomatosis; Benign Meningioma; Malignant Meningioma. On-line free medical diagnosis assistant. Ranked list of possible diseases from either several symptoms or a full patient history. A similarity measure between symptoms and diseases is provided.
Cases reported • Meningioma; Meningiomas, Multiple; Meningiomatosis; Benign Meningioma; Malignant Meningioma. On-line free medical diagnosis assistant. Ranked list of possible diseases from either several symptoms or a full patient history. A similarity measure between symptoms and diseases is provided.
A meningioma is a type of brain tumor thats said to be to second most common type of brain tumor occurring in humans today. A meningioma brain tumor primarily develops in the meninges, the thin layers of tissue surrounding the spinal cord and the brain. In most cases, these brain tumors can grow in size and spread, although its difficult to determine the tumors growth rate. Upon growth, these tumors put pressure on surrounding brain tissue.. Meningiomas can be classified into three grades, as set by the World Health Organization. Grade I meningiomas are classified as benign, Grade II meningiomas are identified as atypical, while Grade III meningiomas are considered anaplastic. Meningiomas are usually benign, but Grade III meningiomas are malignant. The average survival rate for Grade III meningiomas, without relapse, is currently at about three years.. There are some factors that contribute to the development of brain tumors in the meninges. Excessive exposure to ionizing radiation or x-rays ...
Introduction: Meningiomas are predominantly benign tumors, which arise from the arachnoids cap cells. The development mechanism is unknown but they may result from an adverse effect of cranial irradiation and trauma. Antigen KI-67 also known as Ki-67 or MKI67 is a protein that in humans is encoded by the MKI67 gene (antigen identified by monoclonal antibody Ki-67). The antigen KI-67 is a nuclear protein that is associated with and may be necessary for cellular proliferation. Inactivation of antigen KI-67 leads to inhibition of ribosomal RNA synthesis. Ki-67 is an excellent marker to determine the growth fraction of a given cell population, the fraction of Ki-67-positive tumor cells (the Ki-67 labeling index) is often correlated with the clinical course of cancer. Materials and Methods: This is a cross-sectional study that had been performed at the National Center for Neurological Sciences during February 2011 to December 2013. The study included samples from intracranial meningioma patients ...
This report presents magnetic resonance imaging (MRI) findings of a breast carcinoma metastasis in an intracranial meningioma with correlated pathological findings. MRI showed multiple foci of intense enhancement with hypointense surrounding areas. The described foci appeared to be metastatic disease from the patients known breast carcinoma. In addition, this is the first study reported in the literature to have investigated the expression of a possibly common carcinogenic molecule in breast carcinoma metastatic to a coexisting meningioma: overexpressed c-myc oncogene was found both in the breast carcinoma compartment and in the meningioma component of the tumor. ...
TY - JOUR. T1 - Single-fraction radiosurgery of benign intracranial meningiomas. AU - Pollock, Bruce E.. AU - Stafford, Scott L.. AU - Link, Michael J.. AU - Brown, Paul D.. AU - Garces, Yolanda I.. AU - Foote, Robert L.. PY - 2012/9/1. Y1 - 2012/9/1. N2 - BACKGROUND:: Stereotactic radiosurgery (SRS) of benign intracranial meningiomas is an accepted management option for well-selected patients. OBJECTIVE:: To analyze patients who had single-fraction SRS for benign intracranial meningiomas to determine factors associated with tumor control and neurologic complications. METHODS:: Retrospective review was performed of 416 patients (304 women/112 men) who had single-fraction SRS for imaging defined (n = 252) or confirmed World Health Organization grade I (n = 164) meningiomas from 1990 to 2008. Excluded were patients with radiation-induced tumors, multiple meningiomas, neurofibromatosis type 2, and previous or concurrent radiotherapy. The majority of tumors (n = 337; 81%) involved the cranial base ...
TY - JOUR. T1 - Rhabdoid meningioma. T2 - Report of two cases. AU - Reddy, Ch Karunakar. AU - Divakar Rao, A.. AU - Ballal, Chandra K.. AU - Chakraborti, Shrijeet. PY - 2015/2/1. Y1 - 2015/2/1. N2 - Rhabdoid meningioma is an uncommon anaplastic variant of meningioma. We describe the clinicoradiological and histomorphological features of two such cases of meningioma, with a brief review of literature. One case in a 9-year-old girl, presented initially as an atypical meningioma in the right fronto-parietal region, which on recurrence 18 months later, evolved into a rhabdoid meningioma. The second case in a 33-year-old male was located in the right parieto-occipital region.. AB - Rhabdoid meningioma is an uncommon anaplastic variant of meningioma. We describe the clinicoradiological and histomorphological features of two such cases of meningioma, with a brief review of literature. One case in a 9-year-old girl, presented initially as an atypical meningioma in the right fronto-parietal region, which ...
MalaCards based summary : Benign Meningioma, also known as meningioma, benign, is related to secretory meningioma and spinal meningioma. An important gene associated with Benign Meningioma is NF2 (Neurofibromin 2), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. The drugs Hydroxyurea and Gefitinib have been mentioned in the context of this disorder. Affiliated tissues include brain, lung and bone, and related phenotypes are Decreased viability and Decreased viability ...
Coexistence of pituitary adenoma, intracranial meningioma and cerebral aneurysm has never been described. We report on a patient with GH-secreting pituitary macroadenoma associated with a right...
Hallinan JT, Hegde AN, Lim WE. Dilemmas and diagnostic difficulties in meningioma. Clin Radiol. 2013 Aug;68[8]:837-44. http://dx.doi.org/10.1016/j.crad.2013.03.007 PMid:23623578 Fathi AR, Roelcke U. Meningioma. Curr Neurol Neurosci Rep. 2013;13(4):337. http://dx.doi.org/10.1007/s11910-013-0337-4 PMid:23463172 Osborn AG, Salzman KL, Barkovich AJ. Meningioma and atypical and malignant meningioma. In: Osborn AG, editor. Diagnostic imaging: brain. 2nd ed. Salt lake city: Lippincott Williams & Wilkins/Amirys, 2009: p. 72-81. de Almeida JP, Petteys RJ, Sciubba DM, Gallia GL, Brem H. Regression of intracranial meningioma following intratumoral hemorrhage. J Clin Neurosci. 2009;16:1246 9. http://dx.doi.org/10.1016/j.jocn.2008.11.017 PMid:19560362 Goncalves AM, Page P, Domigo V, Meder JF, Oppenheim C. Abrupt regression of a meningioma after discontinuation of cyproterone treatment. AJNR Am J Neuroradiol. 2010;31:1504 5. http://dx.doi.org/10.3174/ajnr.A1978 PMid:20053802 Shimizu J, Matsumoto M, Yamazaki ...
Intracranial meningioma and glioma collision tumors are relatively uncommon and are even more rarely located within the ventricles. Here, we report a case of a patient with an intraventricular meningioma and astrocytoma collision tumor. A 39-year-old man previously underwent excision of an astrocytoma in the triangle area of the lateral ventricle and exhibited good post-surgery recovery. The astrocytoma recurred in situ six years after the surgery, and the case was complicated by a malignant meningioma. The patient recovered well after surgery to treat the recurrence and was administered radiotherapy after discharge. In addition to reporting on this case, we conducted a literature review of collision tumors; based on this review, we propose several hypotheses regarding the formation of collision tumors. We conclude that a possible cause of the collision tumor formation between the intracranial meningioma and the astrocytoma was the recurrence of an astrocytoma-induced malignancy of the arachnoid cells
Request for free sample report: https://www.delveinsight.com/sample-request/meningioma-market. Table of Contents:. 1. Key Insights. 2. Executive Summary of Meningioma. 3. Competitive Intelligence Analysis for Meningioma. 4. Meningioma : Market Overview at a Glance. 4.1. Meningioma Total Market Share (%) Distribution in 2017. 4.2. Meningioma Total Market Share (%) Distribution in 2030. 5. Meningioma : Disease Background and Overview. 5.1. Introduction. 5.2. Sign and Symptoms 5.3. Pathophysiology 5.4. Risk Factors 5.5. Diagnosis 6. Patient Journey. 7. Meningioma Epidemiology and Patient Population. 7.1. Epidemiology Key Findings. 7.2. Assumptions and Rationale: 7MM. 7.3. Epidemiology Scenario: 7MM. 7.3.1. Meningioma Epidemiology Scenario in the 7MM (2017-2030). 7.4. United States Epidemiology. 7.4.1. Meningioma Epidemiology Scenario in the United States (2017-2030). 7.5. EU-5 Country-wise Epidemiology. 7.5.1. Germany Epidemiology. 7.5.1.1. Meningioma Epidemiology Scenario in Germany ...
Dr. Nader Sanai, an Associate Professor of Neurological Surgery at the Barrow Neurological Institute in Phoenix, Arizona, has received a $15,000 grant to fund his latest research project, A Phase 0/II Study of LEE011 in Recurrent Atypical and Malignant Meningioma Patients.. This proposal represents the first Phase 0 atypical and malignant meningioma trial in history. Dr. Sanai and his team will determine the plasma exposure and brain accumulation of LEE011 following 5-day dosing in patients with recurrent atypical and malignant meningiomas; will evaluate select PD biomarkers corresponding to CDK4/6 inhibition, including Rb phosphorylation, cells in M-phase of cell cycle (PH3), and FoxM1 downregulation and explore the safety and efficacy of LEE011 in recurrent atypical and malignant meningioma with demonstrated pharmacokinetic and pharmacodynamic effects.. Dr. Sanai shares, What drives me forward is the opportunity to discover things that others in humankind have never seen, as we as find ...
A case of malignant meningioma which has grown rapidly after gross total removal and metastasized to thoracic spines after second operation is reported. We recommend that early spinal magnetic resonance image should be performed in patient with spinal symptoms and signs after the treatment of intracranial meningioma and intensive treatment combined with operation and radiosurgery should be performed for the reduction of growth rate in the recurred malignant meningoma. ...
Twenty four meningiomas (17 benign and seven atypical were reacted with a panel of monoclonal antibodies to macrophages, lymphocytes, and HLA DR antigens. All the tumours contained macrophages but these cells were more numerous in the atypical meningiomas. Lymphocytes, almost exclusively of the CD8 subtype, were also present in 70% of benign meningiomas and in all atypical meningiomas and were more abundant in the latter. B lymphocytes were present in minimal numbers in three atypical meningiomas and in one benign meningioma. CD4 positive T lymphocytes were present in small numbers in one benign meningioma and in moderate numbers in one atypical meningioma. HLA DR antigen expression on tumour cells was present in about 60% of both tumour groups. The numbers of macrophages and T and CD8 lymphocytes in meningiomas seem to be related to atypical histological features, and the presence of these cells raises questions about host immune response and the relation of this to prognosis.. ...
Intraventricular Malignant Meningioma - Malignant meningioma· Intraventricle· Frontal horn· Third ventricle· Surgical approach.J Korean Neurosurg Soc 34 : 379-381;KISEP380 J Korean Neurosurg Soc 34Intraventricular Malignant Meningiomaand was removed a piecemealfashion using biopsy forceps
Meningiomas are mostly benign brain tumours, with a potential for becoming atypical or malignant. On the basis of comprehensive genomic, transcriptomic and epigenomic analyses, we compared benign meningiomas to atypical ones. Here, we show that the majority of primary (de novo) atypical meningiomas display loss of NF2, which co-occurs either with genomic instability or recurrent SMARCB1 mutations. These tumours harbour increased H3K27me3 signal and a hypermethylated phenotype, mainly occupying the polycomb repressive complex 2 (PRC2) binding sites in human embryonic stem cells, thereby phenocopying a more primitive cellular state. Consistent with this observation, atypical meningiomas exhibit upregulation of EZH2, the catalytic subunit of the PRC2 complex, as well as the E2F2 and FOXM1 transcriptional networks. Importantly, these primary atypical meningiomas do not harbour TERT promoter mutations, which have been reported in atypical tumours that progressed from benign ones. Our results ...
Meningiomas account for approximately 30% of all primary central nervous system tumors and are found in half of neurofibromatosis type 2 patients often causing significant morbidity. Although most meningiomas are benign, 10% are classified as atypical or anaplastic, displaying aggressive clinical behavior. Biallelic inactivation of the neurofibromatosis 2 (NF2) tumor suppressor is associated with meningioma formation in all NF2 patients and 60% of sporadic meningiomas. Deletion of the p16INK4a/p14ARF locus is found in both benign and malignant meningiomas, while mutation of the p53 tumor suppressor gene is uncommon. Previously, we inactivated Nf2 in homozygous conditional knockout mice by adenoviral Cre delivery and showed that Nf2 loss in arachnoid cells is rate-limiting for meningioma formation. Here, we report that additional nullizygosity for p16Ink4a increases the frequency of meningioma and meningothelial proliferation in these mice without modifying the tumor grade. In addition, by using ...
Temporal bone meningioma can be considered as a part of the ectopic meningioma group. The known female preponderance of intracranial meningiomas is also seen in external auditory canal meningioma.4 Up to 20% of intracranial meningiomas may have extraneuraxial extension, 5,6,7,8. including the skull, scalp (all cutaneous sites), orbit, upper airway involvement (nasal cavity, paranasal sinuses, nasopharynx), soft tissues, and ear / temporal bone. However, when the scalp, orbit, sinonasal tract, oral cavity, and soft tissues are excluded, the incidence decreases to ,1% 6, 9, 10, 11. Ectopic or extracranial meningiomas are classified into 4 subgroups: direct extension from primary intracranial meningioma, extracranial growth from cranial nerve sheath arachnoidcells, extracranial extension from embryonic arachnoid rests without connection to the skull base or cranial nerves, and distant metastasis from intracranial tumors.3 Meningioma gains access to the temporal bone from 3 principal sites of ...
Introduction Forkhead Box M1 (FOXM1) and aryl hydrocarbon receptor (AHR) signaling pathway participate in meningioma development, but their correlation was inadequately studied. The study is aimed to uncover their functions and correlation in malignant meningioma. Material and methods...
Background: Meningioma is one of the primary brain tumors that most often occurs at the age of 60-70 years, originating from arachnoid cap cells. FGF-2 as a growth factor is a potent stimulator of endothelial proliferation which is very important in the process of angiogenesis. FGF-2 levels in meningiomas have been assessed using the ELISA and qrPCR methods in many previous studies using blood serum in malignant cases with normal brain tissue as control. This study used tissue samples of meningioma tumors in which most cases of meningioma are benign. Objective: To assess the association between immunohistochemical expressions of FGF-2 and histopathology grade among meningioma patients. Material and Method: Formalin-fixed paraffin-embedded tissue blocks of 32 meningioma patients were immunohistochemically studied for FGF-2 expression. The basic characteristics of the samples were obtained through medical records or pathology archieves. The association between FGF-2 expression and grade were ...
TY - JOUR. T1 - Preoperative Embolization of Intracranial Meningiomas. AU - Yoshida, Kazunari. AU - Toya, Shigeo. AU - Takamiya, Yoshiaki. AU - Murakami, Hideki. AU - Kawase, Takeshi. AU - Shiga, Hayao. PY - 1985. Y1 - 1985. N2 - The method and results for preoperative embolization are described in 36 cases with intracranial meningiomas. Embolization materials were injccted through a transfemoral catheter, selectively placed in the external carotid artery. Chopped gelfoam served as embolization material in 29 patients and ivalon particles were used in 7 patients. In 19 out of 36 cases the feeding arteries arose only from the external carotid artery system and were completely occluded (complete embolization) except in 3 cases. The remaining 17 cases also had feeders of the tumor capsule or at the site of the insertion arising from the internal carotid artery system (partial embolization). Thirty-three cases were followed by computed tomography (CT) between embolization and operation. Contrast ...
Meningioma Mommas is asking for help to fund an exciting new project by the team of University of Colorado researchers we have previously funded. Please help us help the researchers find better treatment options for meningioma patients by donating here or via our own Donate page.. From the researchers:. PROJECT SUMMARY. Meningiomas are a common brain tumor, considered to be the most prevalent primary brain tumor in the central nervous system. In spite of their burden, no FDA approved pharmacotherapies exist for the treatment of these tumors. Through our work with Meningioma Mommas, we have created a high throughput drug screen that allows us to directly measure the sensitivity of individual tumors to hundreds of FDA approved compounds. This approach has identified several possible treatments that have the ability to treat meningiomas broadly by targeting epigenetic processes. Many of the drugs in this class can cross the blood brain barrier making these ideal candidates for further studies. ...
Meningioma is the most common extra-axial benign brain tumor. It is more common in females than males. Meningioma has both typical and atypical features. The diagnosis of typical meningioma is easier than atypical. Major differential diagnoses fo...
TY - JOUR. T1 - Metastatic meningioma in fine-needle aspiration (FNA) of the lung. T2 - Cytomorphologic finding. AU - Baisden, Blaire L.. AU - Hamper, Ulrike M.. AU - Ali, Syed Z.. PY - 1999/5. Y1 - 1999/5. N2 - Pulmonary metastasis of intracranial meningioma is rare. We present the cytomorphologic features of such a tumor in a 71 yr-old woman who was found to have multiple lung nodules 13 years following the resection of an atypical intracranial meningioma. Cytomorphologic features were quite distinct and included hypercellularity with large syncytial groups of monomorphic cells with epithelioid morphologic features, often in perivascular arrangements. Occasional intranuclear cytoplasmic inclusions as well as binucleated cells with wispy cytoplasmic extensions were also noted. Immunoperoxidase studies showed focal positivity for epithelial membrane antigen. The differential diagnosis includes primary or metastatic adenocarcinoma, malignant mesothelioma, and melanoma.. AB - Pulmonary metastasis ...
Anaplastic meningiomas (also known as malignant meningiomas) are uncommon, accounting for only ~1% of all meningiomas 1. Along with rhabdoid meningioma and papillary meningioma are considered WHO grade III tumors and demonstrate aggressive local ...
Meningiomas, which invade intracranial bone structures and the adjacent connective tissue, are frequently unresectable because of their aggressive and recalcitrant growth behavior. They have a high recurrence rate, and in approximately 10% of these tumors there is an increased risk of malignancy. Significant morbidity and mortality rates associated with recurrent meningiomas demand nonsurgical approaches. To date, adjuvant hormonal treatment has not proven beneficial. The anticancer drug hydroxyurea was therefore tested for its potential use in the treatment of meningiomas.. Early-passaged cell cultures were established from 20 different meningiomas. The addition of 5 X 10−4 and 10−3 M hydroxyurea over a period of 5 to 9 days resulted in a remarkable decrease in cell proliferation and even blocked tumor cell growth when compared with untreated cells. A significant arrest of meningioma cell growth in the S phase of the cell cycle was revealed on DNA flow cytometry.. Electron micrographs of ...
The aim of this work was to study the vascular endothelial growth factor A (VEGF-A) pathway and peritumoral brain edema (PTBE) through comparison of non-angiomatous and angiomatous meningiomas. Meningiomas are common intracranial tumors, which often have PTBE. VEGF-A is an integral part of PTBE formation and angiogenesis, and the capillary-rich angiomatous meningiomas are known for their PTBE. The VEGF-A receptor VEGFR-2 is responsible for the angiogenic effect of VEGF-A on endothelial cells, which is enhanced by the co-receptor neuropilin-1. Forty non-angiomatous, 22 angiomatous meningiomas, and 10 control tissue samples were collected for the study. Magnetic resonance images were available for 40 non-angiomatous and 10 angiomatous meningiomas. Tissue sections were immunostained for CD34, MIB-1, estrogen- and progesterone receptors. ELISA, chemiluminescence, and RT-qPCR were used for VEGF-A, VEGFR-2, and neuropilin-1 protein and mRNA quantification. Angiomatous meningiomas had larger PTBE (695 ...
BackgroundTo study the association between use of wireless phones and meningioma.MethodsWe performed a case-control study on brain tumour cases of both genders aged 18-75 years and diagnosed during 2007-2009. One population-based control matched on gender and age was used to each case. Here we report on meningioma cases including all available controls. Exposures were assessed by a questionnaire. Unconditional logistic regression analysis was performed.ResultsIn total 709 meningioma cases and 1,368 control subjects answered the questionnaire. Mobile phone use in total produced odds ratio (OR) = 1.0, 95% confidence interval (CI) = 0.7-1.4 and cordless phone use gave OR = 1.1, 95% CI = 0.8-1.5. The risk increased statistically significant per 100 h of cumulative use and highest OR was found in the fourth quartile (|2,376 hours) of cumulative use for all studied phone types. There was no statistically significant increased risk for ipsilateral mobile or cordless phone use, for meningioma in the temporal
Meningiomas are uncommonly associated with cysts and account for 1.6-10% of intracranial meningiomas 1) 2) 3) Those with more numerous smaller peripheral cysts are more frequent (8-23% of cases). They are over-represented in male patients and the paediatric population Clinical presentation Patients present clinically in the same way as patients with non-cystic meningiomas, with either symptoms related to increased intracranial pressure (ICP), focal neurology, or seizures. Pathology Various mechanisms have been proposed, and probably more than one is applicable depending on the location of the cysts: degeneration or necrosis direct secretion by meningioma reactive changes (peripheral arachnoid cysts) Classification Nauta et al. divided cystic meningiomas into four subtypes according to the location of the cyst with respect to the brain and meningioma type 1: intratumoral cyst(s), located centrally within the meningioma type 2: intratumoral cyst(s), situated peripherally within the meningioma but ...
A sphenoid wing meningioma is a benign brain tumor near the sphenoid bone. A meningioma is a benign brain tumor. It originates from the arachnoid (not the dura), the tissue covering the brain and spinal cord lying deep to the dura. Meningiomas are much more common in females, and are more common after 50 years of age. Of all cranial meningiomas, about 20% of them are in the sphenoid wing. In some cases, deletions involving chromosome 22 are involved. Sphenoid wing meningiomas are diagnosed by the combination of suggestive symptoms from the history and physical and neuroimaging by magnetic resonance imaging (MRI) or computer averaged tomography (CT). Tumors growing in the inner wing (clinoidal) most often cause direct damage to the optic nerve leading especially to a decrease in visual acuity, progressive loss of color vision, defects in the field of vision (especially cecocentral), and an afferent pupillary defect. If the tumor continues to grow and push on the optic nerve, all vision will be ...
Meningiomas are tumours of the membranes that cover the brain. Meningiomas are described as atypical when the tumor cells do not appear typical or normal. The standard treatment for patients with atypical meningioma is surgery to remove the tumour. Radiotherapy to kill any tumour cells left behind after surgery (post-operative radiotherapy) can increase the patient survival rate. The aim of this study is to find out whether a form of radiotherapy called carbon ion boost in combination with post-operative photon radiotherapy can improve the patient survival rate after 3 years ...
TY - JOUR. T1 - Fatal hemorrhagic infarction of posterior fossa meningioma during cardiopulmonary bypass. AU - Sun, Hai. AU - Ross, Donald (Don). PY - 2012/2. Y1 - 2012/2. N2 - Few publications address cardiac surgery in the presence of meningioma. Individual complications include transient visual loss from a suprasellar meningioma, hemiparesis after mitral valve replacement with recovery after resection, and non-fatal hemorrhage into a posterior fossa meningioma. The largest report of 16 patients with known meningiomas over 11 years suggested a benign course, with no new neurologic symptoms and no required resection of a meningioma over an average follow-up of 31 months. In 2 cases we report a presumed posterior fossa meningioma led to fatal outcome after cardiac surgery performed on bypass. Possible causes and future considerations are discussed.. AB - Few publications address cardiac surgery in the presence of meningioma. Individual complications include transient visual loss from a ...
TY - JOUR. T1 - Anatomic location is a risk factor for atypical and malignant meningiomas. AU - Kane, Ari J.. AU - Sughrue, Michael E.. AU - Rutkowski, Martin J.. AU - Shangari, Gopal. AU - Fang, Shanna. AU - McDermott, Michael W.. AU - Berger, Mitchel S.. AU - Parsa, Andrew T.. N1 - Copyright: Copyright 2011 Elsevier B.V., All rights reserved.. PY - 2011/3/15. Y1 - 2011/3/15. N2 - BACKGROUND: Grade II and III meningiomas have higher rates of tumor recurrence than grade I meningiomas after surgery and/or external irradiation. As the utility of noninvasive treatments for brain tumors increases, it is becoming increasingly important to assess the likelihood that a tumor is not benign before treatment initiation. Hence, the authors have reviewed a large series of their patients to determine risk factors for higher-grade pathology, with particular interest paid to tumor location. METHODS: The authors reviewed 378 patients presenting at their institution from 2000 to 2007 with histologically ...
Background: Concomitant dural arteriovenous fistulas (DAVFs) and meningiomas have been rarely described. DAVFs can be either continuous or at a distant location from the meningioma, with different pathophysiologic mechanisms involved in each situation.. Case Description: We report the case of a 74-year-old woman presenting with left-sided hemiparesis secondary to a large right convexity meningioma, associated with a noncontiguous Borden 3 DAVF. Both lesions were treated surgically in the same setting. The patient improved after surgery, and postoperative imaging showed complete resection of the meningioma and absence of recurrence of the fistula at 4 years.. Conclusion: To the best of our knowledge, this is the first case of concomitant surgical treatment of a meningioma and noncontiguous DAVF.. Keywords: Dural arteriovenous fistula, DAVF, Meningioma, Vascular malformations. ...
BACKGROUND: The etiologies of glioma and meningioma tumors are largely unknown. Although reproductive hormones are thought to influence the risk of these tumors, epidemiologic data are not supportive of this hypothesis; however, few cohort studies have published on this topic. We examined the relation between reproductive factors and the risk of glioma and meningioma among women in the European Prospective Investigation into Cancer and Nutrition (EPIC). METHODS: After a mean of 8.4 years of follow-up, 193 glioma and 194 meningioma cases were identified among 276,212 women. Information on reproductive factors and hormone use was collected at baseline. Cox proportional hazard regression was used to determine hazard ratios (HR) and 95% confidence intervals (95% CI). RESULTS: No associations were observed between glioma or meningioma risk and reproductive factors, including age at menarche, parity, age at first birth, menopausal status, and age at menopause. A higher risk of meningioma was observed ...
TY - JOUR. T1 - SINDROME DI WERNER E MENINGIOMA INTRACRANICO. AU - Borroni, G.. AU - Vignati, G.. AU - Zaccone, C.. AU - Brazzelli, V.. AU - Scappaticci, S.. AU - Cerimele, D.. AU - Rabbiosi, G.. PY - 1989. Y1 - 1989. N2 - A case of Werners Syndrome in a 47-year-old man, with typical features of pangeria associated with intracranial meningioma is described. A review of the literature showed that meningioma is the most frequent benign neoplasm in Werners Syndrome. Meningioma is a peculiar model of neoplasm, because of the frequency of cytogenetical aberrations concerning chromosome n. 22. Either chromosome n. 22 and other chromosomal alterations could be detected in peripheral blood lymphocytes of our patient. These findings suggest a correlation between chromosomal instability and the onset of neoplasms in Werners Syndrome. Furthermore, the possibility of detecting chromosome n. 22 aberrations in peripheral blood lymphocytes of Werners Syndrome patients could provide a clue to the presence ...
Primary extradural meningiomas are rare, accounting for less than 2% of all meningiomas; most cases involve the skull. A review of 169 cases was published by Lang et al.2 Only 3 cases of primary meningioma involving the mandible have been reported so far. The first case was by Landini and Kitano in 19923; another 2 cases were by Jones and Freedman in 2001.4 All patients, including ours, were women, and the radiographic presentation was a lytic lesion. Three cases of extracranial meningioma of the maxilla have been reported, excluding cases within the paranasal sinuses. A male patient presented with an oral lesion and a multilocular radiolucency on a periapical x-ray film.5 In 2 female patients, dental x-ray demonstrated a mixed radiolucent-radiopaque mass6 with ill-defined margins in 1 patient.7. To our knowledge, the appearance of mandibular meningioma in CT and MR imaging has not been previously reported.. The lesion in our patient appeared as a cystic lesion of the mandibular body on ...
MENINGIOMA. Meningiomas are extra-axial tumours and represent the most common tumour of the meninges. They are a non-glial neoplasm that originates from the arachnoid cap cells of the meninges. They are typically benign with a low recurrence rate but rarely can be malignant.. Typical meningiomas appear as dural based masses isointense to grey matter on both T1 and T2 weighted imaging, and demonstrate vivid contrast enhancement on both MRI and CT. There are, however, many variants some of which can vary dramatically in their imaging appearance. Epidemiology. Meningiomas are more common in women, with a ratio of 2:1 intracranially and 4:1 in the spine. Atypical and malignant meningiomas are slightly more common in males. They are uncommon in patients before the age of 40 and should raise suspicion of neurofibromatosis type 2(NF2) when found in young patients.. Grading. Generally follows the WHO classification for CNS tumours:. ...
2Hacettepe Üniversitesi Tıp Fakültesi Beyin Cerrahisi Anabilim Dalı, Ankara Meningiomas represent approximately 13-26% of primary intracranial tumours. Many small meningiomas have no symptoms during life and may be found incidentally at autopsy. Such incidental meningiomas are detected more frequently in recent years because of the advent of CT and MRI. Malignant (anaplastic) meningiomas are less common lesions, accounting for 1-2.8% of meningiomas. Recently, clear cell and chordoid meningiomas have been classified as WHO Grade II and rhabdoid and papillary meningiomas classified as WHO Grade III tumors without pathological criteria for malignancy. Here we report a rare case of rhabdoid meningioma in a 31 year-old man. Using the presented case we discuss the prognostic significance of recognition of a rhabdoid meningioma in light of the literature. Anahtar Kelimeler : Meningioma, rhabdoid meningioma, prognostic significance ...
TY - JOUR. T1 - Optic nerve seeding of atypical meningiomas presenting with subacute visual loss. T2 - 2 case reports with genetic characterization. AU - Kitamura, Yohei. AU - Akiyama, Takenori. AU - Sasaki, Hikaru. AU - Hayashi, Yuichiro. AU - Yoshida, Kazunari. PY - 2013/8. Y1 - 2013/8. N2 - Meningiomas rarely cause CSF dissemination, and CSF seeding to the optic nerve (ON) is extremely rare. This is the first report of 2 cases of atypical meningioma with subacute visual loss due to ON seeding. The authors present the genetic characteristics of these atypical meningiomas with CSF dissemination. The patient in Case 1 was a 36-year-old woman with a 1.5-cm mass within the left ON, and the patient in Case 2 was a 70-year-old woman with a 0.9-cm mass around the right ON. Both individuals had undergone multiple surgeries for primary lesions and local recurrent lesions. They presented with subacute visual loss, and both tumors were completely resected. The pathological diagnosis was atypical ...
Meningiomas account for around 25% of primary brain tumours, and most often occur between the age of 40 and 70 years. They are more common in females. Atypical meningiomas are more aggressive than benign meningiomas, and account for around 5% of all meningiomas. Around 4% of meningiomas are malignant ...
Secretory meningioma is a distinct subtype of meningioma. We describe the cytologic features of a secretory meningioma on squash preparations, in comparision with other cytologic mimickers. A 54-year-old woman presented with hearing loss, vertigo, tinnitus, and headache for seven years. A brain MRI study revealed a 4.5 cm sized mass in the cerebellopontine angle, which showed homogenous signal intensity in T2-weighted image. The intraoperative squash smear showed some well-defined, thin rimmed intracytoplasmic inclusions, containing a finely granular eosinophilic core among less cohesive meningiomatous cells. Histologic sections revealed a meningothelial meningioma with scattered inclusions, with periodic acid-Schiff, carcinoembryonic antigen, and cytokeratin positivity. Identification of characteristic intracytoplasmic inclusions is helpful for diagnosing secretory meningiomas. On squash preparations, differential diagnoses included tumors with inclusions or cytoplasmic vacuolizations, such as ...
TY - JOUR. T1 - Cognitive outcomes in meningioma patients undergoing surgery. T2 - Individual changes over time and predictors of late cognitive functioning. AU - Rijnen, S.. AU - Meskal, I.. AU - Bakker, M.. AU - Rutten, G.. AU - Gehring, K.. AU - Sitskoorn, M.. PY - 2018. Y1 - 2018. U2 - 10.1093/neuonc/noy139.387. DO - 10.1093/neuonc/noy139.387. M3 - Meeting Abstract. VL - 20. SP - iii317-iii317. JO - Neuro-Oncology. JF - Neuro-Oncology. SN - 1522-8517. IS - suppl 3. ER - ...
TY - THES. T1 - Cognitive functioning in meningioma patients. T2 - Insights in individual test performances and changes of performance after surgery. AU - Meskal, Ikram. PY - 2018. Y1 - 2018. M3 - Doctoral Thesis. SN - 978-94-6375-224-4. PB - Ridderprint. CY - s.l.. ER - ...
Background: Meningioma is a frequent primary intracranial tumor, the etiology of which is potentially related to adiposity. Metabolic syndrome (MetS) is an increasingly common disease characterized by having at least three of the following conditions: central adiposity, arterial hypertension, dyslipidemia, and insulin resistance. Only one prior study investigated MetS in relation to meningioma risk and found a positive association between the two. Results: Among 2,027 cases and 20,269 controls, body mass index was positively associated with meningioma (p-value for trend , 0.0001). Arterial hypertension was also associated with an increased risk of meningioma (OR = 1.34; 95% CI = 1.20-1.49). By comparison, high-density lipoprotein, triglycerides, fasting serum glucose, and use of ACE-inhibitors, AT-II inhibitors, beta-blockers, diuretics, calcium antagonists, nitrates, or statins were not associated with risk of meningioma. Materials and Methods: We conducted a matched case-control analysis using ...
Optic nerve sheath meningiomas and optic nerve gliomas can be difficult to differentiate by computed tomography (CT). Three patients with optic nerve sheath meningiomas were studied with a CT/T 8800 scanner with 1.5-mm-thick axial sections and intravenous contrast material. In each case, an abnormal optic nerve sheath was identified by CT. A soft-tissue mass arose from one side of the sheath in one patient, and the entire sheath was enlarged in two patients. This provides a basis for distinguishing optic nerve sheath meningioma from optic nerve glioma. ...
TY - JOUR. T1 - Rapid growth and regression of intracranial meningiomas in lymphangioleiomyomatosis. T2 - case report. AU - Pozzati, Eugenio. AU - Zucchelli, Mino. AU - Schiavina, Mario. AU - Contini, Paola. AU - Foschini, Maria Pia. PY - 2007/12. Y1 - 2007/12. N2 - Background: Lymphangioleiomyomatosis is a progressive interstitial lung disease that affects young women. It has been suggested that estrogens play a role in its evolution, and progesterone therapy is often provided in these cases. Case Description: We present a case of a postmenopausal woman with LAM treated with progesterone; subsequently, rapid growth of multiple intracranial meningiomas was observed. One prominent lesion was excised, and 3 other lesions regressed spontaneously over 2 years. Conclusions: This is a rare case of a non-pregnancy-related regression of meningiomas in a woman affected by LAM. The significance of this association and the hormonal treatment of the disease are discussed.. AB - Background: ...
TY - JOUR. T1 - Optic nerve sheath meningiomas. T2 - Visual improvement after stereotactic radiotherapy. AU - Liu, James K.. AU - Forman, Scott. AU - Hershewe, Gerard L.. AU - Moorthy, Chitti R.. AU - Benzil, Deborah L.. AU - Kondziolka, Douglas. AU - Adler, John R.. AU - Loeffler, Jay S.. AU - Gutin, Philip H.. AU - Pollock, Bruce E.. PY - 2002/5/1. Y1 - 2002/5/1. N2 - OBJECTIVE: The management of primary optic nerve sheath meningioma (ONSM) is controversial. Surgery often results in postoperative blindness in the affected eye and thus has been abandoned as a treatment option for most patients. When these tumors are left untreated, however, progressive visual impairment ensues, which also leads to blindness. Recently, radiation therapy has gained wider acceptance in the treatment of these lesions. Experience with stereotactic radiotherapy (SRT) in the treatment of ONSMs is limited because of the rare incidence of this tumor. We present a series of patients with ONSM who were treated with SRT. ...
TY - JOUR. T1 - Precision radiation therapy for optic nerve sheath meningiomas. AU - Eng, Tony Y.. AU - Albright, N. W.. AU - Kuwahara, G.. AU - Akazawa, C. N.. AU - Dea, D.. AU - Chu, G. L.. AU - Hoyt, W. F.. AU - Wara, W. M.. AU - Larson, D. A.. PY - 1992. Y1 - 1992. N2 - A more precise radiation therapy technique to treat unilateral optic nerve sheath meningioma is presented. It uses an immobilization device to align the ipsilateral optic nerve with a vertical axis and employs three small half-beam blocked fields to deliver radiation to a small conformal volume, thereby reducing the dose to the optic chiasm and the contralateral optic nerve. Three patients were successfully treated with this technique, and a fourth patient with optic nerve glioma was also treated in a similar fashion and was included in this study. The new technique irradiates a much smaller volume of tissue to high dose levels: 58 cm3 is irradiated to the 80% isodose level and only 18 cm3 to the 95% level. In contrast, the ...
Meningioma is a primary central nervous tumour (CNS) affecting mostly adults. Skull base meningiomas cause morbidity (and occasionally mortality) by compressing adjacent critical organs, and the aim of treatment is to optimise and preserve CNS function. Radiotherapy is an effective treatment for meningioma, with doses of 50-54Gy in conventional fractionation schedules resulting in long-term local control rates of 80-90%. However, local recurrence is unacceptably high in aggressive histological subtypes (WHO G2 and G3), and these patients have a poor outcome following standard dose regimens. In recent years Intensity-Modulated Radiotherapy (IMRT) has been developed, and can deliver highly conformal dose distributions with sharp dose gradients, making dose escalation a possibility for many tumours, including those located in the skull base. The aim of this thesis was to address two issues pertaining to the role of radiotherapy for skull base meningioma. Firstly the goal was to investigate the ...
Hey guys! I am 37 years old & was recently diagnosed with an optic nerve sheath Meningioma. In a matter of three years I have lost all vision in my right eye. Most would think, as I did, you have 2 eyes- youll be okay with just one & boy […]
TY - JOUR. T1 - Endoscopic endonasal versus open transcranial resection of anterior midline skull base meningiomas. AU - Komotar, Ricardo J.. AU - Starke, Robert M.. AU - Raper, Daniel M.S.. AU - Anand, Vijay K.. AU - Schwartz, Theodore H.. PY - 2012/5/1. Y1 - 2012/5/1. N2 - Objective: To assess the advantages and limitations of the endoscopic endonasal approach to anterior skull base meningiomas, a minimally invasive approach that avoids extensive bone drilling, brain retraction, and manipulation of nerves and critical vessels, versus open transcranial surgery. Methods: A MEDLINE (2000-2010) search was performed to identify series for either olfactory groove meningiomas or tuberculum sellae (TS) or planum sphenoidale meningiomas. Statistical analyses of categorical variables such as extent of resection, morbidity, and visual outcome were performed using χ 2 and Fisher exact tests. Results: The literature review included 60 studies, involving 1426 patients. Open surgery achieved a higher rate ...
Management of Recurrent Skull Base Meningiomas Keywords: anaplastic, atypical, chemotherapy, endoscopic surgery, meningioma, microsurgery, minimally-invasive, radiosurgery, recurrence, skull base Sheri K. Palejwala, Garni Barkhoudarian, Walavan Sivakumar, Daniel F. Kelly Abstract Skull base meningiomas, due to their frequent investment or encasement of critical neurovascular structures, are challenging to resect in their entirety, both with initial resection…
Definition of meningotheliomatous meningioma. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms and definitions.
IMPORTANCE Diagnostic errors can lead to the initial misdiagnosis of optic nerve sheath meningiomas (ONSM), which can lead to vision loss. ...
TY - JOUR. T1 - Addressing Misdiagnosis of Optic Nerve Sheath Meningiomas. AU - Kalen, Brian D.. AU - Hess, Ryan A.. AU - Abi-Aad, Karl R.. AU - Welz, Matthew E.. AU - Patra, Devi P.. AU - Sharma, Akanksha. AU - Mrugala, Maciej M.. AU - Porter, Alyx B.. AU - Bendok, Bernard R.. AU - Acierno, Marie D.. PY - 2020/1. Y1 - 2020/1. UR - http://www.scopus.com/inward/record.url?scp=85076866243&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=85076866243&partnerID=8YFLogxK. U2 - 10.1016/j.wneu.2019.10.122. DO - 10.1016/j.wneu.2019.10.122. M3 - Article. C2 - 31881557. AN - SCOPUS:85076866243. VL - 133. SP - 419. EP - 420. JO - World Neurosurgery. JF - World Neurosurgery. SN - 1878-8750. ER - ...
The authors present the technical and anatomical nuances needed to perform an endoscopic endonasal removal of a tuberculum sellae meningioma. The patient is a 47-year-old female with headaches and an incidental finding of a small tuberculum sellae meningioma with no vascular encasement, no optic canal invasion, but mild inferior to superior compression of the cisternal segment of the left optic nerve. Neuroophthalmology assessment revealed no visual defects. Treatment options included clinical observation with imaging follow-up studies, radiosurgery, and resection. The patient elected to undergo surgical removal and an endonasal endoscopic approach was the preferred surgical option. Preoperative radiological studies showed the presence of an osseous ring between the left middle and anterior clinoids, the so-called carotico-clinoidal ring. The surgical implications of this finding and its management are illustrated. The surgical anatomy of the suprasellar region is reviewed, including concepts ...
To evaluate the impact of 68Ga-DOTATOC-PET on treatment planning and sparing of normal tissue in the treatment of skull base meningioma with advanced photons and protons. From the institutional database consisting of 507 skull base meningiomas 10 patients were chosen randomly for the present analysis. Target volume definition was performed based on CT and MRI only, as well as with additional 68Ga-DOTATOC-PET. Treatment plans were performed for Intensity Modulated Radiotherapy (IMRT) and proton therapy using active raster scanning on both target volumes. We calculated doses to relevant organs at risk (OAR), conformity indices as well as differences in normal tissue sparing between both radiation modalities based on CT/MRI planning as well as CT/MRI/PET planning. For photon treatment plans, PET-based treatment plans showed a reduction of brain stem Dmax and Dmedian for different levels of total dose. At the optic chiasm, use of 68Ga-DOTATOC significantly reduces Dmax; moreover, the Dmedian is reduced in
TY - JOUR. T1 - Endoscopic transsphenoidal resection of a mid-clival meningioma. AU - Alexander, Hamish. AU - Robinson, Simon. AU - Wickremesekera, Agadha. AU - Wormald, Peter. PY - 2010/3. Y1 - 2010/3. N2 - Advances in transsphenoidal endoscopic surgery have allowed difficult clival tumours such as meningiomas causing effacement of the pons and basilar artery to be approached by this technique. We report a clival meningioma resected via a transsphenoidal endoscopic approach.. AB - Advances in transsphenoidal endoscopic surgery have allowed difficult clival tumours such as meningiomas causing effacement of the pons and basilar artery to be approached by this technique. We report a clival meningioma resected via a transsphenoidal endoscopic approach.. KW - Clivus. KW - Endoscope. KW - Meningioma. KW - Transsphenoidal approach. UR - http://www.scopus.com/inward/record.url?scp=75349085050&partnerID=8YFLogxK. U2 - 10.1016/j.jocn.2009.06.037. DO - 10.1016/j.jocn.2009.06.037. M3 - Article. VL - ...
Optic nerve sheath meningiomas (ONSM) are rare benign tumors of the optic nerve. 60-70% of cases occur in middle age females, and is more common in older adults (mean age 44.7 years). It is also seen in children, but this is rare. The tumors grow from cells that surround the optic nerve, and as the tumor grows, it compresses the optic nerve. This causes loss of vision in the affected eye.[1] Rarely, it may affect both eyes at the same time.[2] It is typically a slow growing tumor, and has never been reported to cause death. However, there is concern that the tumor can grow into the brain and cause other types of neurological damage. In some patients, the tumor grows so slowly that treatment is not necessary. Standard treatments are observation, surgery, radiation therapy, and combinations of the above.[1] ...
Detection of TP53 gene mutation in human meningiomas: A study using immunohistochemistry, polymerase chain reaction/single-strand conformation polymorphism and DNA sequencing techniques on paraffin-embedded samples ...
Contents: The Fundamentals.- The History of Stereotactic Radiosurgery.- Neuroimaging in Radiosurgery Treatment Planning and Follow-up Evaluation.- Techniques of Stereotactic Radiosurgery.- Radiation Biology and Physics.- The Physics of Stereotactic Radiosurgery.- Radiobiological Principles Underlying Stereotactic Radiation Therapy.- Experimental Radiosurgery Models.- Treatment Planning for Stereotactic Radiosurgery.- Designing, Building and Installing a Stereotactic Radiosurgery Unit.- Stereotactic Radiosurgery Techniques.- Gamma Knife Radiosurgery.- Linear Accelerator Radiosurgery.- Proton Beam Radiosurgery: Physical Bases and Clinical Experience.- Robotics and Radiosurgery.- CyberKnife Radiosurgery.- Treatment of Disease Types.- Brain Metastases.- Metastatic Brain Tumors: Surgery Perspective.- Brain Metastases: Whole-Brain Radiation Therapy Perspective.- High-Grade Gliomas.- Malignant Glioma: Chemotherapy Perspective.- Meningioma.- Meningioma: Surgery Perspective.- Intracranial Meningioma: ...
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The authors report a novel technique of balloon-assisted embolization of a skull base meningioma supplied by a branch of the cavernous segment of the internal carotid artery using liquid embolic agent. A temporarily inflated balloon distal to the meningiomas feeding vessel may improve the access to this small branch and may reduce the chances of unintended reflux during delivery of the liquid embolic agent. ...
TY - JOUR. T1 - Morbidity and mortality associated with meningioma after cranial radiotherapy. T2 - A report from the childhood cancer survivor study. AU - Bowers, Daniel C.. AU - Moskowitz, Chaya S.. AU - Chou, Joanne F.. AU - Mazewski, Claire M.. AU - Neglia, Joseph P.. AU - Armstrong, Gregory T.. AU - Leisenring, Wendy M.. AU - Robison, Leslie L.. AU - Oeffinger, Kevin C.. PY - 2017/5/10. Y1 - 2017/5/10. N2 - Purpose: Little is known about neurologic morbidity attributable to cranial radiotherapy (CRT) -associated meningiomas. Materials and Methods: From 4,221 survivors exposed to CRT in the Childhood Cancer Survivor Study, a diagnosis of meningioma and onset of neurologic sequelae were ascertained. Cox proportional hazards regression was used to estimate hazard ratios (HR) and 95% CIs to evaluate the factors associated with neurologic sequelae after subsequent meningioma. Results: One hundred ninety-nine meningiomas were identified among 169 participants. The median interval from primary ...
TY - JOUR. T1 - Skull base meningiomas. AU - Couldwell, William T.. AU - Heros, Roberto. AU - Dolenc, Vinko. PY - 2011/5. Y1 - 2011/5. UR - http://www.scopus.com/inward/record.url?scp=84858619086&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84858619086&partnerID=8YFLogxK. U2 - 10.3171/2011.3.FOCUS1185. DO - 10.3171/2011.3.FOCUS1185. M3 - Editorial. C2 - 21529181. AN - SCOPUS:84858619086. VL - 30. JO - Neurosurgical Focus. JF - Neurosurgical Focus. SN - 1092-0684. IS - 5. ER - ...
TY - JOUR. T1 - Intratumoral microhemorrhages on T2*-weighted gradient-echo imaging helps differentiate vestibular schwannoma from meningioma. AU - Thamburaj, K.. AU - Radhakrishnan, V.V.. AU - Thomas, B.. AU - Nair, S.. AU - Menon, G.. N1 - cited By 43. PY - 2008. Y1 - 2008. N2 - BACKGROUND AND PURPOSE: Vestibular schwannomas (VS) may be difficult to differentiate from cerebellopontine angle (CPA) meningiomas. Demonstration of microhemorrhages in VS on T2*-weighted gradient-echo (GRE) sequences may have potential value to differentiate VS from CPA meningiomas. MATERIALS AND METHODS: In this prospective study of 20 patients, MR imaging was performed with T2*-weighted GRE in addition to all basic sequences. Histopathologic examination was performed after surgery. Intratumoral hemosiderin was confirmed by pigment staining. RESULTS: There were 15 patients in the VS group with 16 VS and 5 in the meningioma group with 5 posterior fossa meningiomas. Fourteen of the 16 VS and all 5 meningiomas were ...
MORALES, F. et al. Skull base meningiomas: a predictive system to know the extent of their surgical resection and patient outcome. Neurocirugía [online]. 2005, vol.16, n.6, pp.477-485. ISSN 1130-1473.. Objective. The aim of this study was to build a preoperative predictive system which could pro-vide reliable information about: 1° which skull base meningiomas can be total or partially removed, and 2° their surgical outcome. Method. Patient histories and imaging data were reviewed retrospectively from 85 consecutive skull base meningiomas patients who underwent surgery from 1990 and 2002. From the preoperative data, nine variables were selected for conventional statistical analysis as regards their relationship with: 1° total vs partial tumor resection and 2° with patients outcome according to the degree of tumour removal. Results. From the nine variables analysed only two had a statistical association with the type of tumour resection performed (total vs partial) and the patient outcome: 1) ...
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Meningiomas are a diverse set of tumors arising from the meninges, the membranous layers surrounding the central nervous system. They arise from the arachnoid cap cells of the arachnoid villi in the meninges. These tumors usually are benign in nature; however, a small percentage are malignant. Many meningiomas produce no symptoms throughout a persons life, and if discovered, require no treatment other than periodic observation. Typically, symptomatic meningiomas are treated with either radiosurgery or conventional surgery. Historical evidence of meningiomas has been found going back hundreds of years, with some successful surgeries for their removal beginning in the 1800s. ...
Results The mean age at presentation was 11 years (range: 6-17 years). There were six female patients and two male patients. 2/8 patients had associated neurofibromatosis type 2. Patients were followed up for 71-297 months (mean 156±70 months). 6/8 patients were observed through the course of their disease and 2/8 patients were treated with radiotherapy. 2/8 patients who were observed had minimal change in vision and did not experience tumour growth after long-term follow-up. ...
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Primary Middle Ear Meningioma and Dural/ Ophthalmic Artery Aneurysm Meningiomas are the second most common brain tumor. Though most are found intracranially, a few exhib..
Primary Middle Ear Meningioma and Dural/ Ophthalmic Artery Aneurysm Meningiomas are the second most common brain tumor. Though most are found intracranially, a few exhib..
This morning CNN fed a headline: Sheryl Crow: Brain Tumor is a Bump in the Road. This concerned me, not only because Im a huge fan, but because in 2006, she began treatment for breast cancer at age 43. Singer-songwriter Sheryl Crow says she has a brain tumor, says the first line of the CNN story. I was concerned. It seemed liked shed been getting a little bit closer…to feeling fine.. Fortunately, the LATimes and People magazine got Crows story right. Their headlines, and text, emphasize the benign nature of Crows newly-diagnosed condition, a meningioma. Most meningiomas are benign, local expansions of the cells that line the brain and spinal cord. These growths occasionally cause neurological symptoms. Some patients have surgery to relieve or avoid complications of these non-malignant growths, but many dont need intervention ...
TY - JOUR. T1 - The evolving role of radiosurgery in the management of radiation-induced meningiomas. T2 - A review of current advances and future directions. AU - Mansouri, Alireza. AU - Badhiwala, Jetan. AU - Mansouri, Sheila. AU - Zadeh, Gelareh. N1 - Publisher Copyright: © 2014 Alireza Mansouri et al. Copyright: Copyright 2015 Elsevier B.V., All rights reserved.. PY - 2014. Y1 - 2014. N2 - Meningiomas are among the most common primary adult brain tumors, which arise either spontaneously or secondary to environmental factors such as ionizing radiation. The latter are referred to as radiation-induced meningiomas (RIMs) which, while much less common than their spontaneous counterparts, are challenging from a management point of view. Similar to spontaneous meningiomas, the optimal management of RIMs is complete surgical resection. However, given their high grade, multiplicity, tendency to invade bone and venous sinuses, and high recurrence rate, this cannot always be accomplished safely. ...
TY - JOUR. T1 - Predictors of recurrence in the management of chordoid meningioma. AU - Choy, Winward. AU - Ampie, Leonel. AU - Lamano, Jonathan B.. AU - Kesavabhotla, Kartik. AU - Mao, Qinwen. AU - Parsa, Andrew T.. AU - Bloch, Orin. PY - 2016/1/1. Y1 - 2016/1/1. N2 - Management of chordoid meningiomas (CMs) is complicated by high rates of recurrence, particularly following subtotal resection. Optimal management is not established given the paucity of published experience. To identify prognostic factors for recurrence following resection, the authors conducted the largest systematic review of CMs to date. A comprehensive search on MEDLINE (OVID and Pubmed), Scopus, Embase, and Web of Science utilizing the search terms chordoid AND meningioma was performed to identify all reports of pathologically confirmed intracranial CMs. A total of 221 patients were included, comprising 120 females and 101 males. Mean age, MIB-1/Ki67, and tumor size was 45.5 years, 4.3 % (range 0.1-26.6 %), and 4.1 cm ...
The International Agency for Research on Cancer (IARC) has published the results of the INTERPHONE combined analysis for glioma and meningioma and found overall no increased risk of brain cancer from mobile phone use.. In announcing the results for glioma and meningioma, Dr Christopher Wild, Director of the International Agency for Research on Cancer (IARC) said:. An increased risk of brain cancer is not established from the data from INTERPHONE. However, observations at the highest level of cumulative call time and the changing patterns of mobile phone use since the period studied by INTERPHONE, particularly in young people, mean that further investigation of mobile phone use and brain cancer risk is merited.. The INTERPHONE researchers conclude:. Overall, no increase in risk of glioma or meningioma was observed with use of mobile phones. There were suggestions of an increased risk of glioma at the highest exposure levels, but biases and error prevent a causal interpretation. The possible ...
Doctors give unbiased, trusted information on the use of Gamma Knife Surgery for Meningioma: Dr. Bonuel on radiation necrosis after gamma knife surgery for meningioma: Stereotactic surgery is usually a minimally invasive procedure using x-ray and computers to locate a spot or lesion to perform a needle biopsy through a very small incision. Gamma knife is a non-invasive procedure to deliver very carefully a high dose of radiation therapy with specialized equipment to treat a lesion or tumor with no incision.
This multicentre case-control study of 1906 cases and 5565 controls provides no evidence of any association between occupational exposure to organic solvents and meningioma in the overall study population or in women or men separately. There were also no significant trends of increasing risk with either increasing cumulative exposure or duration of exposure. However, interpretation of these negative findings should take into account the strengths and limitations of the study.. While the INTEROCC study is the largest case-control study conducted to date investigating associations between occupational exposure to organic solvents and meningioma, the relatively low-exposure prevalence in the study population limited its power to identify significant associations and in particular after stratification by gender. Potential sources of selection and recall bias in the design and conduct of the INTERPHONE study on which this study was based have been addressed in detail elsewhere;28 ,36 however, these ...
abstractNote = {A 12 year-old girl was treated with prophylactic cranial irradiation for acute lymphoblastic leukaemia (ALL). At the age of 39, she was admitted to our hospital for status epilepticus. Computed tomography demonstrated two, enhancing bilateral sided intracranial tumors. After surgery, this patient presented meningiomas which histologically, were of the meningothelial type. The high cure rate in childhood ALL, attributable to aggressive chemotherapy and prophylactic cranial irradiation, is capable of inducing secondary brain tumor. Twelve cases of high-dose radiation-induced meningioma following ALL are also reviewed. (author ...
CASE REPORTS Journal of Neurosurgical Sciences 2004 June;48(2):59-62. Solitary fibrous tumor of the tentorium cerebelli. Case report. Pérez-Núñez A., Rivas J. J., Ricoy J. R., Miranda P., Arrese I., Lobato R. D., Ramos A.. Abstract PDF. CASE REPORTS Journal of Neurosurgical Sciences 2004 June;48(2):63-5. Spontaneous rupture of spinal dermoid cyst with disseminated lipid droplets in central canal and ventricles. Goyal A., Singh D., Singh A. K., Gupta V., Sinha S.. Abstract PDF. CASE REPORTS Journal of Neurosurgical Sciences 2004 June;48(2):67-70. Neurological deterioration after head trauma in patients with colloid cysts of the 3rd ventricle. Two case histories. Cultrera F., Parisi G., Platania N., Consoli V., Albanese V.. Abstract PDF. CASE REPORTS Journal of Neurosurgical Sciences 2004 June;48(2):71-73. Metastasis of breast carcinoma to intracranial meningioma. Baratelli G. M., Ciccaglioni B., Dainese E., Arnaboldi L.. Abstract PDF. CASE REPORTS Journal of Neurosurgical Sciences 2004 ...
PRIMARY OBJECTIVES:. I. To determine the efficacy of bevacizumab in patients with recurrent or progressive benign and atypical/malignant meningiomas, despite prior therapy, as measured by six-month progression-free survival.. SECONDARY OBJECTIVES:. I. To describe the response rate and overall-survival in this patient population.. II. To evaluate the safety profile of bevacizumab in patients with recurrent meningiomas.. III. To perform an exploratory study in patients with hemangioblastoma and hemangiopericytoma.. IV. To assess tissue for VEGF and VEGFR to correlate with response. An exploratory analysis of HER-2 will be performed.. OUTLINE:. Patients receive bevacizumab IV over 30-90 minutes every 2 weeks for 6 months. Patients may then receive bevacizumab IV every 3 weeks for up to 12 months. Treatment continues in the absence of disease progression or unacceptable toxicity.. After completion of study treatment, patients are followed every 3 months for 2 years. ...
A case of haemangiopericytic meningioma of the sacral canal in a 25 year old man, an uncommon tumour at a rare site, is described. The tumour was malignant and largely undifferentiated although there was light and electron microscopic evidence of dual differentiation in areas towards haemangiopericytoma and meningioma. The patient, with cauda equina syndrome, was treated by partial resection and post-operative radiotherapy and remains well 12 months after treatment.. ...
TY - JOUR. T1 - Meningiomas of the tuberculum and diaphragma sellae. AU - Ajlan, Abdulrazag M.. AU - Choudhri, Omar. AU - Hwang, Peter. AU - Harsh, Griffith. PY - 2015/2. Y1 - 2015/2. N2 - Introduction Although tuberculum sellae (TS) and diaphragma sellae (DS) meningiomas have different anatomical origins, they are frequently discussed as a single entity. Here we review the radiologic and intraoperative findings of TS and DS meningiomas and propose a radiologic classification. Methods We retrospectively reviewed 10 consecutive TS and DS meningiomas. Data regarding clinical presentation, preoperative imaging, and intraoperative findings were analyzed. Three sellar dimensions were measured on magnetic resonance imaging (MRI): the tuberculum-sellar floor interval (TSFI), the planum-tuberculum interval (PTI), and the total height. Results Three distinct anatomical patterns were recognized: exclusively tubercular meningiomas (type A) were accompanied by elongation of the TSFI and, more significantly, ...
There has been a lot of talk in the press lately about dental x-rays and their possible links to a specific brain tumor known as intracranial meningioma. The study that was covered extensively on national news was conducted by asking to two groups of people about their history of dental x-rays. One group had the […] ...
2The Second Affiliated Hospital of Xinjiang Medical University, Department of Neurosurgery, Urumqi, China DOI : 10.5137/1019-5149.JTN.8670-13.1 AIM: This study aimed to investigate the operative procedure for neuroendoscope-assisted microscopic resection of petroclival meningioma to improve prognosis.. MATERIAL and METHODS: Twelve patients with petroclival meningioma who had undergone neuroendoscope-assisted microscopic resection at the Department of Neurosurgery, First Affiliated Hospital of Xinjiang Medical University were selected. In addition, 12 patients with petroclival meningioma who had undergone microscopic surgery were used as control. Clinical data from the 24 cases of petroclival meningioma were analyzed.. RESULTS: For the neuroendoscope-assisted group, six, five, and one cases were respectively subjected to total resection, subtotal resection, and most resection. For the microscopic surgery group, two, three, and seven cases were respectively subjected to total resection, subtotal ...
People who have had frequent dental X-rays may have an increased chance of developing a meningioma, one of the most commonly diagnosed brain tumors, according to a new study. Most meningiomas are non-malignant, but they can grow very large. Depending upon their location in the skull, they can also cause severe symptoms like memory loss, frequent headaches, vision and hearing loss and seizures. Ionizing radiation, such as X-rays, is the biggest risk factor for developing a meningioma.
Malignant anaplastic meningioma is aggressive. Although anaplastic meningioma has higher chances of distant metastasis than the ... MR/CT scans of meningioma from MedPix MR/CT scans of pneumosinus dilatans from MedPix Cancer.Net: Meningioma (Webarchive ... Starr CJ, Cha S (September 2017). "Meningioma mimics: five key imaging features to differentiate them from meningiomas". ... atypical and anaplastic meningiomas identifies novel genes associated with meningioma progression". International Journal of ...
... is a rare, fast-growing tumor that forms in one of the inner layers of the meninges (thin layers of tissue ... Malignant meningioma entry in the public domain NCI Dictionary of Cancer Terms This article incorporates public domain material ... The World Health Organization classification system defines both grade II and grade III meningiomas as malignant. Historically ... Benign or low grade meningiomas (WHO grade I) include meningothelial, fibrous, transitional, psammomatous, angiomatous, ...
... (also known as "Heterotopic meningeal tissue," and "Rudimentary meningocele") is a developmental defect, ...
A sphenoid wing meningioma is a benign brain tumor near the sphenoid bone. A meningioma is a benign brain tumor. It originates ... Meningiomas are much more common in females, and are more common after 50 years of age. Of all cranial meningiomas, about 20% ... Meningiomas. New York: Raven Press, 1991. Bonnal J, A Thibaut, J Brotchi, and J Born. Invading Meningiomas of the Sphenoid ... Treatment of meningioma. UpToDate, online, April 7, 2006. Schmidek, H. Meningiomas and Their Surgical Management. Philadelphia ...
About 1-2% of all meningiomas are optic nerve sheath meningiomas. Meningiomas have an incidence of ~4.18/100,000 persons each ... Thus, ~10,000 meningiomas are diagnosed in the US each year; corresponding to ~100 cases of ONSM each year in the US. The ... Optic nerve sheath meningiomas (ONSM) are rare benign tumors of the optic nerve. 60-70% of cases occur in middle age females, ... Wright JE, Call NB, Liaricos S (1980). "Primary optic nerve meningioma". Br J Ophthalmol. 64 (8): 553-558. doi:10.1136/bjo.64.8 ...
Meningioma is a cranial disorder and is characterised by tumor growth on the meninges, surrounding the blood vessels and nerves ... Other diseases include meningioma, a tumor surrounding essential blood vessels and nerves that may be near the crown, causing ... "Meningioma - Symptoms and Causes". www.pennmedicine.org. Retrieved 2020-10-21. Berger, A. (2002-01-05). "How does it work?: ... The patients that have meningioma develop signs and symptoms including amnesia and epileptic seizures. The direct impact to the ...
HF1 Meningioma; 607174; MN1 Meningioma, NF2-related, somatic; 607174; NF2 Menkes disease; 309400; ATP7A Mental retardation and ...
Many meningiomas, with the exception of some tumors located at the skull base, can be successfully removed surgically. Most ... Tumors of the meninges are meningiomas and are often benign. Though not technically a tumor of brain tissue, they are often ... Since they are usually slow-growing tumors, meningiomas can be quite large by the time symptoms appear. The brains of humans ... "Meningioma Brain Tumor". neurosurgery.ucla.edu. Retrieved 29 July 2019. "Neurons & Glial Cells , SEER Training". training.seer. ...
Gil M, Oliva B, Timoner J, Maciá MA, Bryant V, de Abajo FJ (December 2011). "Risk of meningioma among users of high doses of ... A hemangioblastoma mimicking a meningioma has been reported in a man treated with CPA. The combination of low-dose (2 mg) CPA ... Raj R, Korja M, Koroknay-Pál P, Niemelä M (2018). "Multiple meningiomas in two male-to-female transsexual patients with hormone ... Ter Wengel PV, Martin E, Gooren L, Den Heijer M, Peerdeman SM (December 2016). "Meningiomas in three male-to-female transgender ...
... or a chordoid meningioma. In particular, meningiomas are known to produce musical auditory hallucinations such as Schumann ... Scott, M (1979). "Musical hallucinations from meningioma". JAMA. 241 (16): 1683. doi:10.1001/jama.1979.03290420011006. PMID ...
... showed that the owner of the skull suffered from a meningioma, which is an arachnoid tumor. Meningiomas are a diverse set of ... Meningiomas are very rare with roughly 2 out of 100,000 causing symptoms, so finding evidence of one in such ancient remains is ... It is the earliest evidence of a meningioma tumor on record. List of fossil sites (with link directory) List of hominina ( ... It is also possible that no neurological deficiencies were suffered, due to the slow growing nature of meningiomas. Whether the ...
In the differential diagnosis, schwannoma and meningioma with pigmentation are to be considered as well. Melanocytomas have ... Limas C, Tio FO (1972). "Meningeal melanocytoma ("melanotic meningioma"). Its melanocytic origin as revealed by electron ...
Rao SB, Dinakar I, Rao KS (December 1971). "Giant intracranial epidural meningioma". Journal of Neurosurgery. 35 (6): 748-50. ...
They have a grade 2 or 3 biological behavior, and need to be distinguished from benign meningiomas because of their high rate ... When inside the nervous system, although not strictly a meningioma tumor, it is a meningeal tumor with a special aggressive ... Berlin: Springer-Verlag (2nd ed.) (30). Sherman W, Raizer J. Dropcho EJ (ed.). "Meningiomas". Medmerits: 2. Archived from the ... Maier H, Ofner D, Hittmair A, Kitz K, Budka H (October 1992). "Classic, atypical, and anaplastic meningioma: three ...
Seker, Askin; Martins, Carolina; Rhoton Jr., Albert L. (2010). "2 - Meningeal Anatomy". Meningiomas. Saunders. pp. 11-51. doi: ...
A tumor growing from the meninges is referred to as a meningioma. Most meningiomas grow from the arachnoid mater inward ... While meningiomas make up 20% of primary brain tumors and 12% of spinal cord tumors, 90% of these tumors are benign. ... Meningiomas tend to grow slowly and therefore symptoms may arise years after initial tumor formation. The symptoms often ... "Meningiomas". Mayfield Clinic. Retrieved 23 March 2011. Wikimedia Commons has media related to Pia mater. Martini, F. Timmons, ...
ISBN 978-0-8089-2306-0. Kawase, Takeshi (2010). "38 - Petroclival Meningiomas: Middle Fossa Anterior Transpetrosal Approach". ... Meningiomas. Saunders. pp. 495-501. doi:10.1016/B978-1-4160-5654-6.00038-6. ISBN 978-1-4160-5654-6. Anatomy photo:22:os-0902 at ...
Zada, Gabriel; Jensen, Randy L. (2016). Meningiomas. Philadelphia, Pennsylvania. ISBN 978-0323443890. Atlas of Sellar and ...
Seker, Askin; Martins, Carolina; Rhoton, Albert L. (2010). "2 - Meningeal Anatomy". Meningiomas. Saunders. pp. 11-51. doi: ...
Seker, Askin; Martins, Carolina; Rhoton Jr., Albert L. (2010). "2 - Meningeal Anatomy". Meningiomas. Saunders. pp. 11-51. doi: ...
Lahmeyer HW (June 1982). "Frontal lobe meningioma and depression". The Journal of Clinical Psychiatry. 43 (6): 254-5. PMID ...
This gene is a candidate meningioma gene. Two transcript variants encoding different isoforms have been found for this gene, ... a candidate meningioma gene". Hum Mol Genet. 3 (8): 1393-9. doi:10.1093/hmg/3.8.1393. PMID 7987321. Peyrard M, Pan HQ, Kedra D ...
Cerrón Rojas, Vladimir Roy (2001). "Meningioma in the pediatric age: rare case". Neurol Journal 5 (33): 495-497. Cerrón Rojas, ...
ISBN 9781598848311 Chan, Amanda, "What's a meningioma? The science of Mary Tyler Moore's brain tumor" NBCNews.com (May 12, 2011 ...
"Co-existing fibrous dysplasia and meningothelial meningioma". Arquivos de Neuro-Psiquiatria. 67 (3): 699-700. doi:10.1590/S0004 ...
In 2011, she had surgery to remove a meningioma, a benign brain tumor. In 2014, friends reported that Moore had heart and ... ISBN 9781598848311 Chan, Amanda, "What's a meningioma? The science of Mary Tyler Moore's brain tumor" NBCNews.com (May 12, 2011 ... Goldmann, Russell (May 12, 2011). "Mary Tyler Moore Has Brain Surgery for Meningioma Tumor". ABC News. Retrieved July 6, 2019. ...
Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where ...
Wood was diagnosed in 1910 with a benign meningioma, which was successfully resected by Harvey Cushing. He made a full recovery ... Lee, Joung H. (2009). Meningiomas: Diagnosis, Treatment, and Outcome. Springer. p. 8. ISBN 978-1-84882-910-7. Wood, Eric Fisher ...
Adjuvant radiotherapy for atypical meningiomas (2017) Couldwell, WT; Bagshaw, HP; Burt, LM; Suneja, G; Jensen, RL; Palmer, CA ( ... A description of familial clustering of meningiomas in the Utah population (2017) Couldwell, WT; CannonAlbright, LA (2017). "A ... Clinical Outcomes with Transcranial Resection of the Tuberculum Sellae Meningioma (2017) Couldwell, WT; CannonAlbright, LA ( ... 2017). "Clinical Outcomes with Transcranial Resection of the Tuberculum Sellae Meningioma". World Neurosurgery. 108: 748-755. ...
A series of case reports have found it to be effective in the treatment of an estrogen receptor (ER)-dependent meningiomas as ... 470-. ISBN 978-0-08-045593-8. Joung H. Lee (11 December 2008). Meningiomas: Diagnosis, Treatment, and Outcome. Springer Science ... on the regression of intracranial meningiomas in the elderly]". Brain Nerve (in Japanese). 66 (8): 995-1000. PMID 25082321. ... "Regression of a presumed meningioma with the antiestrogen agent mepitiostane". Journal of Neurosurgery. 93 (1): 132-135. doi: ...
Meningioma, the term coined by Harvey Cushing, refers to a set of tumors that arise contiguously to the meninges. . ... Psammomatous meningioma (arrow indicates psammoma body). C, Meningothelial meningioma, tumor in case 4. E, Meningioma with ... Meningioma refers to a set of tumors that arise contiguously to the meninges (see the image below). Meningiomas may occur ... Meningiomas are more prevalent in Africa than in North America or Europe. In Los Angeles County, meningioma is reported more ...
Meningiomas are often benign tumors arising from the coverings of the brain and spinal cord and occur most frequently in middle ... Multiple meningiomas occur in 5-15% of patients, particularly those with NF-2. Meningiomas also frequently have extra copies of ... Meningiomas are graded 1, 2, or 3. A higher grade signifies that the meningioma is more aggressive. ... Meningioma can occur in people of all ages but are most likely to be found in older adults (median age of 65). Rarely are ...
Felix Plater first described meningiomas at an autopsy. In 1938, Harvey Cushing introduced them as a separate category of ... 2] The 5- and 10-year survival rates for atypical meningiomas were over 85%. For malignant meningiomas, the survival rate is ... encoded search term (Optic Nerve Sheath Meningioma) and Optic Nerve Sheath Meningioma What to Read Next on Medscape ... Optic Nerve Sheath Meningioma Follow-up. Updated: May 11, 2021 * Author: Mitchell V Gossman, MD; Chief Editor: Edsel B Ing, MD ...
Unknown author (‎2009)‎. Cyproterone : risk of meningiomas. https://extranet.who.int/iris/restricted/handle/10665/74474 ...
Although they can arise in numerous locations, meningiomas of the internal auditory canal (IAC) are rare. Most tumours that ... Meningiomas account for approximately 18 to 19 per cent of all brain tumours. ... Meningioma of the internal auditory canal with extension into the vestibule J Laryngol Otol. 1999 Dec;113(12):1101-3. doi: ... Meningiomas account for approximately 18 to 19 per cent of all brain tumours. Although they can arise in numerous locations, ...
rhabdoid meningioma (DOID:5058) Alliance: disease page Synonyms: meningioma, rhabdoid; Papillary meningioma Alt IDs: NCI:C6909 ...
Leksell Top 25 - Meningioma You are looking at 1 - 8 of 8 items for * Refine by Access: all x ... Meningiomas of the cerebral convexity are often surgically curable because both the mass and involved dura mater can be removed ... COVID-19 Leksell Top 25 - Meningioma Leksell Top 25 - Vestibular Schwannoma Leksell Top 25 - Since 2005 Top 25 Cited Gamma ... Parasellar and sellar meningiomas are challenging tumors owing in part to their proximity to important neurovascular and ...
Richard Dodge was diagnosed with a meningioma, a benign brain tumor. But his wife Myra has remained committed to helping him ... Richard Dodge was diagnosed with a meningioma, a benign brain tumor. But his wife Myra has remained committed to helping him ... After Richards meningioma surgery, most of his symptoms improved remarkably. Since it was a benign tumor, he didnt have to go ... Ferguson performed a craniotomy to remove Richards tumor, which turned out to be a baseball-sized grade II meningioma, a ...
... reminded me of the first time I saw a patient with a meningioma. It was 1995. I was a junior neurosurgery resident, and my ... Gupta: Waiting out a meningioma. All the news about one of my favorite actresses, Mary Tyler Moore, reminded me of the first ... Truth is, while there are many types of brain tumors that do require urgent operations, meningiomas are often treated ... time I saw a patient with a meningioma. It was 1995. I was a junior neurosurgery resident, and my professor introduced me to a ...
Skullbase Tumors - Meningioma and Skullbase Tumors. Overview. *We use a multidisciplinary approach to these often complex and ...
The Pre-Sigmoid Posterior Petrosectomy Approach for Skull Base Meningiomas. Sandeep Kandregula, Bharat Guthikonda. Department ... However, the skull base approaches are still the standard of treatment for larger meningiomas. In this illustrative case, Tyagi ... Kandregula S, Guthikonda B. The Pre-Sigmoid Posterior Petrosectomy Approach for Skull Base Meningiomas. Neurol India 2022;70: ... Kandregula S, Guthikonda B. The Pre-Sigmoid Posterior Petrosectomy Approach for Skull Base Meningiomas. Neurol India [serial ...
meningioma brain tumor For two years Sherri was convinced that she was one of those unlucky people who was destined to have ... Horne had anticipated, the tumor was a benign meningioma, and thus had not spread to other parts of Sherris brain.. During the ...
Primary orbital angiomatous meningioma. Journal Article (Journal Article) Full Text. *Published version (via Digital Object ...
Somatostatin receptor-targeted radiopeptide therapy with 90Y-DOTATOC and 177Lu-DOTATOC in progressive meningioma: long-term ... Somatostatin Receptor-Targeted Radiopeptide Therapy in Patients with Progressive Unresectable Meningioma Message Subject (Your ... Peptide receptor radionuclide therapy in patients with inoperable meningiomas: our experience and review of the literature. ... We thus concluded that, considering the lack of significant toxicity, peptide receptor radionuclide therapy of meningiomas ...
Recurrent Meningioma , Grade 2 Meningioma , Grade 1 Meningioma , Unresectable Meningioma , Lutathera for the Treatment of ... Inoperable, Progressive Meningioma After External Beam Radiation Therapy ... Grade 1 Meningioma, Grade 2 Meningioma, Grade 3 Meningioma, Recurrent Meningioma, Unresectable Meningioma ... Optic nerve sheath meningioma, extracranial meningioma Yes for Optic nerve sheath meningioma, extracranial meningioma exclusion ...
Read this weeks research update focusing on meningioma in childhood cancer survivors and medulloblastoma recurrence. Find out ... Pooled Analysis of Meningioma Risk Following Treatment for Childhood Cancer Meningioma is the most common abnormal tissue ... Meningioma in childhood cancer survivors and medulloblastoma recurrence Latest news categories. * Brain Tumour Research ... Published in Jama Oncology, this study aimed to evaluate the meningioma risk in survivors of childhood cancer following ...
The relationship between arachnoid hyperplasia in optic nerve glioma and meningioma of the optic nerve sheath in childhood is ... an optic nerve glioma with a marked degree of arachnoid hyperplasia which was initially diagnosed as an optic nerve meningioma ...
... of all orbital meningiomas, the majority of which are direct extensions from intracranial meningiomas. These tumors typi... ... Optic nerve meningiomas are benign tumors arising from the arachnoid cap cells of the optic nerve sheath and represent ~20% ... Meningiomas of the optic nerve sheath have the same imaging characteristics as meningiomas elsewhere. The morphology of the ... of all orbital meningiomas, the majority of which are direct extensions from intracranial meningiomas. ...
Meningiomas of grades I and II appear to share biomarkers with malignant tumors, but with some additional tumor suppressor ... Nuclear Cyclin D1 expression was positive in all studied meningiomas, while its expression in arachnoid was limited to a few ... Deep sequencing of small RNA libraries generated from two human meningioma biopsies WHO grades I (benign) and II (atypical) ... Meningiomas represent the most common primary tumors of the central nervous system, but few microRNA (miRNA) profiling studies ...
We test the method on brain scans of patients with meningioma, which experts have found difficult to monitor because the tumor ... The sensitivity of experts visual inspection is often too low to detect subtle growth of meningiomas from longitudinal scans. ... A new metric for detecting change in slowly evolving brain tumors; validation in meningioma patients.pdf (1.581Mb) ... We test the method on postgadolinium, T1-weighted magnetic resonance images of 10 patients with meningioma and compare our ...
I found out that the meningioma in my brain has doubled in size. This is my gameplan for the next few months. ... The Meningioma in my Brain is Growing, Now What?. by Dr. Diane Roberts Stoler, Ed.D. , Jan 9, 2014 , Personal Experiences , 9 ... Hi I was diagnosed with a meningioma October 2019. Great to hear that Dr Diane is doing well. Can you share some of your tips ... Diane is using her 5 prong approach on herself and her meningioma is smaller than it was. Dr. Diane takes the time to care for ...
Of 126 cases of surgery in 118 elderly patients, the approach was a minimally invasive approach to skull base meningioma (SBM) ... RESULTS: Of 291 patients (median age 60 years, 71.5% females, mean follow-up 36 months) undergoing meningioma resection, 118 ( ... Notably, one-third of our elderly meningioma patients referred for possible surgery from 2015 to 2019 were managed ... During 2015-2019, of 98 patients referred for meningioma, 67 (68%) had surgery, 1 (1%) had radiosurgery, and 31 (32%) were ...
... and meningioma 14.5%). In MTHFR A1298C, CC genotype was observed to have reduced risk of having meningioma than AA genotype (OR ... and meningioma 19.7%) and TT genotype (control 3.8%, glioma 2.8% and meningioma 5.3%). For MTHFR A1298C, AC was the major ... The major genotype observed for MTHFR C677T was CC genotype in both controls (71.2%) and cases (glioma 73.1%, meningioma 75%) ... Current study includes 288 brain tumor cases (Glioma=108 and Meningioma=76) and 104 healthy control subjects. Genomic DNA ...
Meningioma Mommas only funds meningioma specific research and is proud to kick off 2017 by fully funding Harvard University and ... Meningioma Mommas Rings in 2017 Fully Funding New Grant!. News and UpdatesBy Liz Holzemer. January 4, 2017. ... Hiroaki Wakimoto, with a $25,048 grant to launch their project, "Anti-angiogenic Oncolytic Virus Therapy for Meningioma." This ... We provide support and valuable resources to all those affected by meningioma brain tumors. ...
I have meningioma … blah, blah, wait and watch and small cavernoma. "Probably there forever, dont worry". You face your own ... Meningioma behind left ear, to meet with neurosurgeon. Scared.. Posted by nahi @nahi, Dec 17, 2017 ... I know the feeling of "but its not supposed to be there!" Most meningiomas are not cancer. So they decided to take the watch ... I was diagnosed with a grape-sized meningioma Sept 2 following an MRI. Mine is..." + (show)- (hide) ...
Giant posterior fossa meningioma: the importance of early diagnosis and challenges concerning treatment ... Histology revealed a grade I meningioma. The surgical approach for such huge lesions on pontocerebellar angle is controversial ... Giant posterior fossa meningioma: the importance of early diagnosis and challenges concerning treatment ...
Understanding Meningioma Biology: Abrar Choudhury. June 24, 2021. Meningioma is the most common intracranial tumor, with ... In order to identify new therapies for meningioma, it is important to understand their underlying biology. In this Share Your ... Abrar Choudhury describes how he studied DNA methylation to understand the biology of meningioma and identify a novel candidate ... which began by looking at DNA methylation patterns to better understand gene regulation in meningioma, leading him to identify ...
... has played a central role in the treatment of parasellar meningiomas. Evaluation of tumor control rates at this location using ... The volumes of the parasellar meningioma were computed by segmenting the meningioma on a slice-by-slice basis with numerical ... Introduction: Stereotactic radiosurgery (SRS) has played a central role in the treatment of parasellar meningiomas. Evaluation ... Conclusions: SRS is a durable and minimally invasive treatment modality for benign parasellar meningiomas. Volumetric ...
meningioma in posterior fossa. [1]. View: Weekly list ✔ Monthly list ✔ Monthly calendar ✔ Weekly list ...
Dive into the research topics of Metastatic meningioma presenting as cancer of unknown primary. Together they form a unique ...
  • Meningioma refers to a set of tumors that arise contiguously to the meninges (see the image below). (medscape.com)
  • On plain head CT scans, meningiomas are usually dural-based tumors that are isoattenuating to slightly hyperattenuating. (medscape.com)
  • The frequency of meningiomas in Africa is nearly 30% of all primary intracranial tumors. (medscape.com)
  • Meningiomas are often benign tumors arising from the coverings of the brain and spinal cord. (abta.org)
  • Most meningiomas are benign (non-cancerous), slow-growing tumors. (abta.org)
  • Although meningiomas are referred to as brain tumors, they do not grow from brain tissue. (abta.org)
  • Meningiomas account for about one-third of all primary brain tumors. (abta.org)
  • Meningiomas also frequently have extra copies of the platelet-derived growth factor (PDFGR) and epidermal growth factor receptors (EGFR), which may contribute to the growth of these tumors. (abta.org)
  • Parasellar and sellar meningiomas are challenging tumors owing in part to their proximity to important neurovascular and endocrine structures. (thejns.org)
  • Truth is, while there are many types of brain tumors that do require urgent operations, meningiomas are often treated differently. (cnn.com)
  • transsphenoidal surgery , including extended approaches for suprasellar and clival tumors (e.g. meningiomas, craniopharyngiomas, chordomas). (uclahealth.org)
  • Optic nerve meningiomas are benign tumors arising from the arachnoid cap cells of the optic nerve sheath and represent ~20% of all orbital meningiomas , the majority of which are direct extensions from intracranial meningiomas . (radiopaedia.org)
  • We provide support and valuable resources to all those affected by meningioma brain tumors. (meningiomamommas.org)
  • Meningiomas, though benign histologically, are relatively common tumors that may behave in an aggressive, clinical fashion. (imrpress.com)
  • Both tumors had second copy inactivation of NF2 , confirming the central role of the gene in meningioma formation. (biomedcentral.com)
  • Besides second NF2 copy inactivation, we found low somatic burden in both tumors and high level of genomic instability in the atypical meningioma. (biomedcentral.com)
  • Meningiomas are the most frequent intracranial tumors. (ncigt.org)
  • Meningiomas are the most common extrinsic brain tumors and follow glioblastoma multiforme (GBMs) as one of the most common intracranial brain tumors. (microneurosurgery.org)
  • Meningiomas are the most common type of brain tumors in adults and occur more often than cancerous brain tumors. (vanderbilthealth.com)
  • Meningiomas are tumors arising from the meninges and represent the most common primary benign tumors in the CNS. (gsdinternational.com)
  • Meningiomas are the most frequent primary central nervous system (CNS) tumors. (amegroups.com)
  • Although this mainly applies to neuroepithelial tumors in meningioma research and classification the connection of histomorphological features and genetic profiles becomes more and more evident. (amegroups.com)
  • Here we report on advances and controversies of meningioma classification in the 2016 edition of the WHO classification of CNS tumors. (amegroups.com)
  • Due to their heterogenous morphological features former and the current edition of the World Health Organization (WHO) classification of tumors of the CNS provide 15 distinct meningioma variants ( Figure 1 ). (amegroups.com)
  • Depending on the tumor localization, benign meningiomas are basically tumors that can be cured by neurosurgical resection ( 2 ). (amegroups.com)
  • The WHO classification of CNS tumors stratifies meningiomas in three major groups, reflected by the WHO grades I (benign), II (intermediate) and III (malignant) ( 5 ) ( Figure 1 ). (amegroups.com)
  • However, for some patients WHO grading seems insufficient as (I) almost 20% of benign WHO grade I tumors tend to recur ( 4 , 6 , 7 ) and (II) adjuvant radiotherapy might not be necessary for all WHO grade II meningiomas ( 8 - 10 ). (amegroups.com)
  • In the current review article we discuss the diagnostic criteria for meningiomas as applied by the current WHO classification for CNS tumors ( 5 ). (amegroups.com)
  • To learn more about meningiomas, Dr. Parham Yashar and his team of friendly staff members have developed this guide to give you all the information you need to know about meningiomas and meningeal tumors. (dryashar.com)
  • Meningiomas refer to tumors that grow in the membrane cells around the brain. (dryashar.com)
  • Meningioma are slow-growing tumors, and are often not even diagnosed until they are of a certain size. (dryashar.com)
  • Meningiomas and schwannomas are two other types of brain tumors. (medlineplus.gov)
  • The goal was to find out whether mobile phone radiation is able to increase the risk of four kinds of cancer - acoustic neuroma, glioma, meningioma, and tumors of the parotid gland. (gsmarena.com)
  • The secondary tumors were mainly meningiomas (n = 13), sarcomas (n = 7), and high-grade gliomas (n = 6), and the mean latency periods were 19.66, 8.00, and 10.83 years, respectively. (elsevier.com)
  • In general, the ideal treatment of a benign meningioma is surgical resection if possible. (medscape.com)
  • 65 y) to younger patients, Black et al evaluated 114 patients undergoing meningioma resection divided into 2 groups, as follows: 57 patients aged 65-87 years and a control group of 57 patients aged 25-64 years matched by the American Society of Anesthesiology (ASA) status and tumor site. (medscape.com)
  • Resection can be undertaken for posterior fossa meningiomas, but residual or recurrent tumor is frequent. (thejns.org)
  • demonstrated an excellent approach combining the sub-temporal and pre-sigmoid posterior petrosectomy for the resection of a large petroclival meningioma. (neurologyindia.com)
  • There has been limited research into how the unique anatomic considerations associated with parasagittal/parafalcine meningioma resection may influence discharge disposition. (elsevier.com)
  • Convexity meningiomas are commonly managed with resection. (thejns.org)
  • The objective of this study was to determine whether postoperative diffusion-weighted imaging (DWI) was associated with neurological deficits after convexity meningioma resection and to identify the risk factors for postoperative DWI restriction. (thejns.org)
  • A retrospective review of patients who had undergone convexity meningioma resection from 2014 to 2018 was performed. (thejns.org)
  • Consequently, a good argument can be made that there are subgroups of meningiomas that tend to recur or even show malignant transformation although gross-total resection was achieved. (amegroups.com)
  • A total of 703 consecutive patients with meningioma underwent resection at The University of Texas Southwestern Medical Center between the years 1994 and 2015. (bvsalud.org)
  • Arie Perry interconnects Local failure, Resection, Recursive partitioning and Nomogram in the investigation of issues within Meningioma. (research.com)
  • Benign meningiomas (WHO grade I) feature a 5-year tumor recurrence rate of 5% as compared to 50-80% for anaplastic meningiomas (grade III), highlighting the importance of elucidating the molecular mechanisms which contribute to tumor progression [ 3 ]. (biomedcentral.com)
  • 18F-FDG PET in the assessment of tumor grade and prediction of tumor recurrence in intracranial meningioma. (medscape.com)
  • Meningiomas are classified as grade I (the most frequent, slow-growing), grade II (atypical meningiomas, more aggressive) and grade III (anaplastic meningiomas, with high risk of local invasion and recurrence). (gsdinternational.com)
  • An adequate classification system aims at providing a tool for estimating recurrence and overall survival of meningioma patients. (amegroups.com)
  • Evaluating risk of recurrence in patients with meningioma. (bvsalud.org)
  • In this study, the authors aimed to test conventional predictors of meningioma recurrence , histopathology variables for which there exists some controversy ( brain invasion), as well as a novel molecular-based location paradigm. (bvsalud.org)
  • Time to meningioma recurrence (i.e., recurrence -free survival [RFS]) was the primary endpoint measured. (bvsalud.org)
  • In patients with high-grade meningiomas ( WHO grade II or III), location was predictive of RFS (p = 0.03, log-rank test), with paravenous meningiomas exhibiting the highest rates of recurrence . (bvsalud.org)
  • The data suggest that brain invasion does not increase the risk of recurrence in otherwise WHO grade I meningioma . (bvsalud.org)
  • Adjuvant radiosurgery to subtotally resected WHO grade I meningiomas did not prolong the time to recurrence . (bvsalud.org)
  • Long-term survival is possible for patients with atypical and malignant meningiomas treated with surgery and postoperative radiation. (medscape.com)
  • The series by Milosevic et al included the records of 59 patients who were treated at the Princess Margaret Hospital from 1966-1990 with histologically confirmed intracranial atypical or malignant meningiomas. (medscape.com)
  • Young age, modern imaging and treatment planning techniques, and postoperative radiation dose of at least 50 Gy contribute to improved outcome in patients with atypical or malignant meningiomas. (medscape.com)
  • Malignant meningioma in Gorlin's syndrome: cytogenetic and p53 gene analysis. (medscape.com)
  • I was a part of the malignant tumor service (eg: gliomas), the benign tumor service (eg: meningiomas), and the pituitary service. (jmsa.org)
  • Interphone was the largest case-control study to date investigating risks related to mobile phone use and to other potential risk factors for the tumours of interest and included 2,765 glioma, 2,425 meningioma, 1,121 acoustic neuroma, 109 malignant parotid gland tumour cases and 7,658 controls. (who.int)
  • Minimally invasive surgical treatment of intracranial meningiomas in elderly patients (≥ 65 years): outcomes, readmissions, and tumor control. (bepress.com)
  • The relationship between arachnoid hyperplasia in optic nerve glioma and meningioma of the optic nerve sheath in childhood is discussed. (bmj.com)
  • Radiofrequency Electromagnetic Fields Emitted from Base Stations of DECT Cordless Phones and the Risk of Glioma and Meningioma. (emfacts.com)
  • The objective of this study was to test the hypothesis that exposure to continuous low-level radiofrequency electromagnetic fields (RF EMFs) increases the risk of glioma and meningioma. (emfacts.com)
  • Interphone was therefore initiated as an international set of case-control studies1 focussing on four types of tumours in tissues that most absorb RF energy emitted by mobile phones: tumours of the brain (glioma and meningioma), acoustic nerve (schwannoma) and parotid gland. (who.int)
  • The current trend is to separate unequivocal meningiomas from other less well-defined neoplasms. (medscape.com)
  • Meningiomas account for approximately 20% of all primary intracranial neoplasms. (medscape.com)
  • Ibebuike K, Ouma J, Gopal R. Meningiomas among intracranial neoplasms in Johannesburg, South Africa: prevalence, clinical observations and review of the literature. (medscape.com)
  • Stereotactic radiosurgery (SRS) has been used to treat meningiomas, and this study evaluates the outcome of this approach for those located in the posterior fossa. (thejns.org)
  • Stereotactic radiosurgery affords a high rate of tumor control and neurological preservation for patients with posterior fossa meningiomas. (thejns.org)
  • In this study, the authors evaluated the outcomes of parasellar and sellar meningiomas managed with Gamma Knife radiosurgery (GKRS) both as an adjunct to microsurgical removal or conventional radiation therapy and as a primary treatment modality. (thejns.org)
  • Previous treatment for meningioma including surgery, when possible, and radiation therapy (conventional fractionated or radiosurgery). (centerwatch.com)
  • During 2015-2019, of 98 patients referred for meningioma, 67 (68%) had surgery, 1 (1%) had radiosurgery, and 31 (32%) were observed. (bepress.com)
  • Stereotactic radiosurgery in the treatment of parasellar meningiomas: long-term volumetric evaluation. (cns.org)
  • Stereotactic radiosurgery (SRS) has played a central role in the treatment of parasellar meningiomas. (cns.org)
  • Long-term outcomes after meningioma radiosurgery: physician and patient perspectives. (medscape.com)
  • Stereotactic radiosurgery for meningiomas. (medscape.com)
  • For all these reasons, patients affected by meningiomas should refer to high-specialized centers: the average number of cases of meningioma that have been treated in the Neurosurgery Unit at San Raffaele Hospital are 300 cases/year considering both surgery and Gamma-Knife radiosurgery. (gsdinternational.com)
  • Here, we present an in-depth genomic study of benign and atypical meningiomas, both from a single NF2 patient. (biomedcentral.com)
  • Patient was a 63 years old woman with a petroclival meningioma and numbness feelings in her left side of her face (V2 and V3 areas). (gsharifi.com)
  • Primary orbital angiomatous meningioma. (duke.edu)
  • Unlike optic nerve gliomas which occur primarily in children, optic nerve meningiomas are usually seen in adults (mean age at presentation 40 years) 1,5 , however up to 25% present in children, in which case they tend to be more aggressive 5 . (radiopaedia.org)
  • In adults, gliomas and meningiomas are the most common. (medlineplus.gov)
  • The study includes approximately 2600 gliomas, 2300 meningiomas, 1100 acoustic neurinomas, 400 parotid gland tumours and their respective controls. (who.int)
  • Posterior fossa meningiomas represent a common yet challenging clinical entity. (thejns.org)
  • At 7 medical centers participating in the North American Gamma Knife Consortium, 675 patients undergoing SRS for a posterior fossa meningioma were identified, and clinical and radiological data were obtained for these cases. (thejns.org)
  • The former arise from the main body of the falx in the frontal (anterior or posterior), central parietal, or occipital regions, whereas inner falcine meningiomas arise in conjunction with the inferior sagittal sinus . (operativeneurosurgery.com)
  • They attributed the lower morbidity and mortality rates after meningioma surgery in elderly patients to better patient selection and surgical techniques and to better preoperative and postoperative care by health care providers. (medscape.com)
  • Pathologic confirmation of meningioma is not required for patients who are not surgical candidates and received radiation therapy based on magnetic resonance imaging (MRI) consistent with meningioma. (centerwatch.com)
  • CONCLUSIONS: This analysis suggests that elderly patients with meningiomas, when carefully selected, generally have excellent surgical outcomes and tumor control. (bepress.com)
  • The following article describes general principles of surgical treatment as well as some of the pitfalls inherent in treating meningiomas in specific intracranial locations. (imrpress.com)
  • Molecular Typing of Meningiomas by Desorption Electrospray Ionization Mass Spectrometry Imaging for Surgical Decision-Making. (ncigt.org)
  • While meningiomas are well delineated on magnetic resonance imaging by their uptake of contrast, surgical limitations still present themselves from not knowing the extent of invasion of the dura matter by meningioma cells. (ncigt.org)
  • Here, we present the characterization of meningioma and dura mater by desorption electrospray ionization mass spectrometry to validate the technique for the molecular assessment of surgical margins and diagnosis of meningioma from surgical tissue in real-time. (ncigt.org)
  • The technology here was tested to distinguish meningioma from dura mater as an approach to precisely define surgical margins. (ncigt.org)
  • Majchrzak K, Tymowski M. Surgical treatment of the tentorial and falco-tentorial junction meningiomas. (medscape.com)
  • In September 2020 at San Raffaele Hospital Professor Mortini together with his team successfully performed for the first time in the world a surgical removal of a brain meningioma with the use of a robotiscope, a digitally controlled robotic device with three-dimensional visualization. (gsdinternational.com)
  • Although the exact cause of meningioma is not known, it has been associated with age and radiation exposure. (abta.org)
  • The exact cause of meningioma is still unknown but it may be assumed that mutation causes the changes in DNA which altered the cell growth and tumor formation occur. (yesdoct.com)
  • Therefore, some patients die with meningioma and not from it. (medscape.com)
  • Multiple meningiomas occur in 5-15% of patients, particularly those with NF-2. (abta.org)
  • Outpatient follow-up care of patients with optic nerve sheath meningioma (ONSM) includes visual acuity testing and field testing, in addition to an imaging study in the form of MRI with gadolinium, preferably every year to check for recurrent disease. (medscape.com)
  • Of these, 36 patients died of meningioma, and 3 patients were alive after further surgery. (medscape.com)
  • A multicenter study of patients with benign sellar and parasellar meningiomas was conducted through the North American Gamma Knife Consortium. (thejns.org)
  • For the period spanning 1988 to 2011 at 10 centers, the authors identified all patients with sellar and/or parasellar meningiomas treated with GKRS. (thejns.org)
  • 1 ) recently presented a study aimed at evaluating the long-term outcome after treatment with 90 Y-DOTATOC and 177 Lu-DOTATOC in patients affected by unresectable progressive meningioma. (snmjournals.org)
  • The authors concluded that 90 Y-DOTATOC and 177 Lu-DOTATOC are promising tools for the treatment of progressive unresectable meningioma, especially in patients with high radiopharmaceutical accumulation in the tumor. (snmjournals.org)
  • Recently, my group reported on peptide receptor radionuclide therapy in 8 patients who had been referred to the unit of nuclear medicine of our university hospital with a diagnosis of meningioma (6 patients) or meningiomatosis (2 patients) ( 2 ). (snmjournals.org)
  • for peptide receptor radionuclide therapy in patients with progressive unresectable meningiomas, even after multimodal treatment, especially in patients with limited treatment options or recurrent lesions. (snmjournals.org)
  • Moreover, our study found that treatment with 111 In-pentetreotide was well tolerated and effective in patients with meningiomas or meningiomatosis. (snmjournals.org)
  • We thus concluded that, considering the lack of significant toxicity, peptide receptor radionuclide therapy of meningiomas using 111 In-pentetreotide can be proposed even today if the use of 177 Lu- or 90 Y-DOTA-peptides seems unsafe, namely in patients with renal impairment or toxicity. (snmjournals.org)
  • I further suggest the use of 111 In-pentetreotide or 177 Lu-DOTA-peptides (characterized by a shorter penetration range than 90 Y-DOTA-peptides) in patients who have progressive unresectable meningiomas involving critical structures (vascular and neural ones) to avoid eventual complications from radiation-induced edema. (snmjournals.org)
  • This phase II trial studies how well lutathera works in treating patients with meningioma that cannot be treated with surgery (inoperable) and is growing, spreading, or getting worse (progressive) after external beam radiation therapy. (centerwatch.com)
  • I. To estimate the efficacy of lutetium Lu 177 dotatate (LUTATHERA) treatment in patients with recurrent grade 1 meningioma as measured by 6-month progression-free survival (PFS) rate. (centerwatch.com)
  • To estimate the efficacy of LUTATHERA treatment in patients with recurrent grade 2 or 3 meningioma as measured by 6-month PFS rate. (centerwatch.com)
  • I. To determine the overall survival (by grade cohort) of patients with recurrent meningioma during or after treatment of LUTATHERA. (centerwatch.com)
  • To determine the toxicity of LUTATHERA treatment in patients with recurrent meningioma. (centerwatch.com)
  • To determine the best objective response (McDonald criteria) of patients with recurrent meningioma during or after treatment of LUTATHERA. (centerwatch.com)
  • To determine the duration of local control with death as a competing risk (by grade cohort) of patients with recurrent meningioma during or after treatment of LUTATHERA. (centerwatch.com)
  • We test the method on brain scans of patients with meningioma, which experts have found difficult to monitor because the tumor evolution is very slow and may be obscured by artifacts related to image acquisition. (harvard.edu)
  • We test the method on postgadolinium, T1-weighted magnetic resonance images of 10 patients with meningioma and compare our results with experts' findings. (harvard.edu)
  • OBJECTIVE: Increased lifespan has led to more elderly patients being diagnosed with meningiomas. (bepress.com)
  • A comparator meningioma cohort of patients ≥ 65 years old who were observed without surgery during the period from 2015 to 2019 was also analyzed. (bepress.com)
  • Of 126 cases of surgery in 118 elderly patients, the approach was a minimally invasive approach to skull base meningioma (SBM) in 64 cases (51%) as follows: endonasal 18, supraorbital 28, minipterional 6, and retrosigmoid 12. (bepress.com)
  • Our findings revealed the significant association between polymorphism of MTHFR A1298C genes of folate metabolizing enzymes with glioma/meningioma patients. (esmo.org)
  • We investigated the effects of various predictors on discharge disposition within a cohort of patients with parasagittal/parafalcine meningioma. (elsevier.com)
  • Meningiomas affect about one half of NF2 patients, and are associated with a higher disease burden. (biomedcentral.com)
  • PET imaging in patients with meningioma-report of the RANO/PET Group. (medscape.com)
  • The authors identified 122 patients who had undergone a total of 125 operations for convexity meningiomas. (thejns.org)
  • Radiation therapy may be used as primary treatment or complementary to surgery, especially when dealing with critically located meningiomas or in patients with worrisome comorbidities. (gsdinternational.com)
  • The management of meningiomas is challenging and often requires a multi-disciplinary approach in which the neurosurgeon works closely with radiation oncologists while tailoring the optimal treatment for these patients to achieve the best results. (gsdinternational.com)
  • Falcine meningioma tends to grow predominately into one cerebral hemisphere but is often bilateral, and in some patients the tumor grows into the inferior edge of the sagittal sinus . (operativeneurosurgery.com)
  • The patients with falcine meningiomas with reference to gender had the following ratio of male:female of 1:2.1 and an average age of 55 years. (operativeneurosurgery.com)
  • This is a retrospective study of a consecutive series of patients with WHO grade I-III meningioma resected at The University of Texas Southwestern Medical Center between 1994 and 2015. (bvsalud.org)
  • Those who evaluate patients with MCS are reminded that meningiomas and other intracranial mass lesions can affect olfaction, and that patients with MCS can have treatable intracranial abnormalities. (cdc.gov)
  • In rare cases, meningiomas occur in an intraventricular or intraosseous location. (medscape.com)
  • Intraventricular chordoid meningioma presenting with Castleman disease due to overproduction of interleukin-6. (medscape.com)
  • Intraventricular meningiomas may present with obstructive hydrocephalus. (medscape.com)
  • Cerebellopontine angle meningiomas: postoperative outcomes in a modern cohort. (medscape.com)
  • Meningiomas produce their symptoms by several mechanisms. (medscape.com)
  • A systematic review of the literature regarding the clinical behavior of small, untreated meningiomas suggests that most meningiomas 2.5 cm or less in diameter do not proceed to cause symptoms in the 5 years following their discovery. (medscape.com)
  • After Richard's meningioma surgery, most of his symptoms improved remarkably. (mdanderson.org)
  • What are the symptoms of a meningioma? (vanderbilthealth.com)
  • A meningioma is often found because of symptoms a person is having. (vanderbilthealth.com)
  • If your meningioma is causing symptoms or is growing, your healthcare provider will likely want to remove it with surgery. (vanderbilthealth.com)
  • You may also be able to use other medicines to treat symptoms caused by the meningioma, such as seizures, excessive vomiting, weakness, and vision disturbances. (vanderbilthealth.com)
  • [ 2 ] The signs and symptoms secondary to meningiomas may appear or become exacerbated during pregnancy but usually abate or improve in the postpartum period. (medscape.com)
  • Stereotypic symptoms: Meningiomas in specific locations may give rise to the stereotyped symptoms listed in the Table. (medscape.com)
  • Conversely, meningiomas in these locations may remain asymptomatic or produce other unlisted symptoms. (medscape.com)
  • The physical findings mirror the aforementioned symptoms and include signs due to raised intracranial pressure, involvement of cranial nerves, compression of the underlying parenchyma, and involvement of bone and subcutaneous tissues by the meningioma. (medscape.com)
  • Removal of the meningioma had little effect on the patient's symptoms. (cdc.gov)
  • 3 cm in diameter while conventional RT may be indicated in bigger lesions or as an adjuvant therapy in high-grade meningiomas. (gsdinternational.com)
  • Meningiomas commonly are found at the surface of the brain, either over the convexity or at the skull base. (medscape.com)
  • However, the skull base approaches are still the standard of treatment for larger meningiomas. (neurologyindia.com)
  • Abdel Kerim A, Bonneville F, Jean B, Cornu P, LeJean L, Chiras J. Balloon-assisted embolization of skull base meningioma with liquid embolic agent. (medscape.com)
  • Meningiomas of the skull base may narrow and even occlude important cerebral arteries, possibly presenting either as transient ischemic attack (TIA)-like episodes or as stroke. (medscape.com)
  • The most common type of meningioma histologically is the meningothelial variety 5 . (radiopaedia.org)
  • Pooled Analysis of Meningioma Risk Following Treatment for Childhood Cancer Meningioma is the most common abnormal tissue growth following cranial irradiation among survivors of childhood cancer. (braintumourresearch.org)
  • They also found that increasing radiation dose was associated with increased risk of meningioma, and suggested that the persistence of elevated risks of meningiomas for 30 years after cranial radiotherapy could help inform surveillance guidelines. (braintumourresearch.org)
  • Pieper DR, Al-Mefty O, Hanada Y, Buechner D. Hyperostosis associated with meningioma of the cranial base: secondary changes or tumor invasion. (medscape.com)
  • The efficacy of SRS has been established for a certain number of indications, including brain metastases, arteriovenous malformations, as an alternative to conventional surgery in cases of interventional difficulties, and in the prevention of the complications of the standard treatments in cases of meningioma and vestibular schwannoma. (bvsalud.org)
  • BACKGROUND: The concurrent diagnosis of meningioma with increased intracranial pressure has not been reported previously in a patient who meets diagnostic criteria for multiple chemical sensitivities (MCS). (cdc.gov)
  • Rarely, chordoid meningiomas can present with hematologic disturbances, namely Castleman syndrome. (medscape.com)
  • When adjusting for the same patient normal appearing white matter shear modulus values, meningiomas were the stiffest tumor-type. (ncigt.org)
  • Body mass index, physical activity, and risk of adult meningioma and glioma: A meta-analysis. (medscape.com)
  • Drug therapy may be used to treat meningiomas that cannot be removed surgically. (abta.org)
  • The authors report the influence of SRS treatment parameters and volumetric changes of benign WHO Grade I parasellar meningiomas after SRS on long-term outcome. (cns.org)
  • SRS is a durable and minimally invasive treatment modality for benign parasellar meningiomas. (cns.org)
  • However, the true prevalence is likely higher than this because autopsy studies reveal that 2.3% of individuals have undiagnosed asymptomatic meningiomas. (medscape.com)
  • For small, asymptomatic meningiomas active surveillance is sometimes the best course of action. (abta.org)
  • The goal of this study is to determine whether this drug is safe and effective in treating meningiomas that progress after radiation treatment. (centerwatch.com)
  • Published in Jama Oncology , this study aimed to evaluate the meningioma risk in survivors of childhood cancer following radiotherapy and chemotherapy, and identify possible modifying factors of radiation-associated risk. (braintumourresearch.org)
  • Meningioma incidence is increased by radiation. (microneurosurgery.org)
  • Even if the tumor is completely removed during surgery, some healthcare providers may still recommend radiation therapy to help prevent another meningioma from developing in the future. (vanderbilthealth.com)
  • Separate studies have being carried out for acoustic neurinoma, glioma, meningioma and tumours of the parotid gland. (who.int)
  • The group mean tumor stiffness, as measured with MRE, correlated with intra-operatively assessed stiffness of meningiomas and pituitary adenomas. (ncigt.org)
  • Hi I was diagnosed with a meningioma October 2019. (drdiane.com)
  • Zij schreef het beste proefschrift op het gebied van de neuropsychologie, afgerond in de periode tussen 1 september 2019 en 1 september 2020. (nvneuropsy.nl)
  • In addition we classify meningiomas into fibroblastic and meningothelial subtypes and more notably recognize meningiomas with NF2 genetic aberrations. (ncigt.org)
  • Arachnoid hyperplasia in optic nerve glioma: confusion with orbital meningioma. (bmj.com)
  • A case is reported of an optic nerve glioma with a marked degree of arachnoid hyperplasia which was initially diagnosed as an optic nerve meningioma. (bmj.com)
  • Optic nerve meningiomas arise from the arachnoid cap cells of the optic nerve sheath, and as such are on the inside of the dura (remember that the arachnoid layer is immediately deep to the inner layer of the dura mater ). (radiopaedia.org)
  • Meningiomas of the optic nerve sheath have the same imaging characteristics as meningiomas elsewhere. (radiopaedia.org)
  • Meningiomas usually grow slowly, and they may produce severe morbidity before causing death. (medscape.com)
  • Meningiomas usually grow slowly and may reach a large size before interfering with the normal functions of the brain. (abta.org)
  • The clinical findings and the radiographical features of meningiomas of the IAC are similar to those of acoustic neuromas. (nih.gov)
  • Pre-operative differentiation between acoustic neuromas and meningiomas of the IAC may be difficult. (nih.gov)
  • For meningioma and acoustic neurinoma, most national studies provided little evidence of an increased risk. (who.int)
  • Eligible cases were all residents of the study region diagnosed during the study period with a confirmed primary glioma, meningioma, or acoustic neuroma. (who.int)