The motion of phospholipid molecules within the lipid bilayer, dependent on the classes of phospholipids present, their fatty acid composition and degree of unsaturation of the acyl chains, the cholesterol concentration, and temperature.
Lipids, predominantly phospholipids, cholesterol and small amounts of glycolipids found in membranes including cellular and intracellular membranes. These lipids may be arranged in bilayers in the membranes with integral proteins between the layers and peripheral proteins attached to the outside. Membrane lipids are required for active transport, several enzymatic activities and membrane formation.
A fluorescent compound that emits light only in specific configurations in certain lipid media. It is used as a tool in the study of membrane lipids.
The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.
Measurement of the polarization of fluorescent light from solutions or microscopic specimens. It is used to provide information concerning molecular size, shape, and conformation, molecular anisotropy, electronic energy transfer, molecular interaction, including dye and coenzyme binding, and the antigen-antibody reaction.
The semi-permeable outer structure of a red blood cell. It is known as a red cell 'ghost' after HEMOLYSIS.
Thin layers of tissue which cover parts of the body, separate adjacent cavities, or connect adjacent structures.
A colorless liquid with a sharp burning taste and slight odor. It is used as a local anesthetic and to reduce pain associated with LIDOCAINE injection. Also, it is used in the manufacture of other benzyl compounds, as a pharmaceutic aid, and in perfumery and flavoring.
Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides see GLYCEROPHOSPHOLIPIDS) or sphingosine (SPHINGOLIPIDS). They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system.
Thin structures that encapsulate subcellular structures or ORGANELLES in EUKARYOTIC CELLS. They include a variety of membranes associated with the CELL NUCLEUS; the MITOCHONDRIA; the GOLGI APPARATUS; the ENDOPLASMIC RETICULUM; LYSOSOMES; PLASTIDS; and VACUOLES.
Artificially produced membranes, such as semipermeable membranes used in artificial kidney dialysis (RENAL DIALYSIS), monomolecular and bimolecular membranes used as models to simulate biological CELL MEMBRANES. These membranes are also used in the process of GUIDED TISSUE REGENERATION.
Artificial, single or multilaminar vesicles (made from lecithins or other lipids) that are used for the delivery of a variety of biological molecules or molecular complexes to cells, for example, drug delivery and gene transfer. They are also used to study membranes and membrane proteins.
The voltage differences across a membrane. For cellular membranes they are computed by subtracting the voltage measured outside the membrane from the voltage measured inside the membrane. They result from differences of inside versus outside concentration of potassium, sodium, chloride, and other ions across cells' or ORGANELLES membranes. For excitable cells, the resting membrane potentials range between -30 and -100 millivolts. Physical, chemical, or electrical stimuli can make a membrane potential more negative (hyperpolarization), or less negative (depolarization).
Salts and esters of the 12-carbon saturated monocarboxylic acid--lauric acid.
A technique applicable to the wide variety of substances which exhibit paramagnetism because of the magnetic moments of unpaired electrons. The spectra are useful for detection and identification, for determination of electron structure, for study of interactions between molecules, and for measurement of nuclear spins and moments. (From McGraw-Hill Encyclopedia of Science and Technology, 7th edition) Electron nuclear double resonance (ENDOR) spectroscopy is a variant of the technique which can give enhanced resolution. Electron spin resonance analysis can now be used in vivo, including imaging applications such as MAGNETIC RESONANCE IMAGING.
Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. Fatty acids are saturated and unsaturated (FATTY ACIDS, UNSATURATED). (Grant & Hackh's Chemical Dictionary, 5th ed)
A naphthalene derivative with carcinogenic action.
A quality of cell membranes which permits the passage of solvents and solutes into and out of cells.
The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.
The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.
Layers of lipid molecules which are two molecules thick. Bilayer systems are frequently studied as models of biological membranes.
Salts and esters of the 18-carbon saturated, monocarboxylic acid--stearic acid.
Derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to a choline moiety. Complete hydrolysis yields 1 mole of glycerol, phosphoric acid and choline and 2 moles of fatty acids.
Molecules which contain an atom or a group of atoms exhibiting an unpaired electron spin that can be detected by electron spin resonance spectroscopy and can be bonded to another molecule. (McGraw-Hill Dictionary of Chemical and Technical Terms, 4th ed)
The resistance that a gaseous or liquid system offers to flow when it is subjected to shear stress. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Alcohols derived from the aryl radical (C6H5CH2-) and defined by C6H5CHOH. The concept includes derivatives with any substituents on the benzene ring.
FATTY ACIDS in which the carbon chain contains one or more double or triple carbon-carbon bonds.
Minute projections of cell membranes which greatly increase the surface area of the cell.
Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.
Agents that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags.
Peroxidase catalyzed oxidation of lipids using hydrogen peroxide as an electron acceptor.
Alkyl compounds containing a hydroxyl group. They are classified according to relation of the carbon atom: primary alcohols, R-CH2OH; secondary alcohols, R2-CHOH; tertiary alcohols, R3-COH. (From Grant & Hackh's Chemical Dictionary, 5th ed)
A darkly stained mat-like EXTRACELLULAR MATRIX (ECM) that separates cell layers, such as EPITHELIUM from ENDOTHELIUM or a layer of CONNECTIVE TISSUE. The ECM layer that supports an overlying EPITHELIUM or ENDOTHELIUM is called basal lamina. Basement membrane (BM) can be formed by the fusion of either two adjacent basal laminae or a basal lamina with an adjacent reticular lamina of connective tissue. BM, composed mainly of TYPE IV COLLAGEN; glycoprotein LAMININ; and PROTEOGLYCAN, provides barriers as well as channels between interacting cell layers.
Measurement of the intensity and quality of fluorescence.
An absence of warmth or heat or a temperature notably below an accustomed norm.
Isomeric forms and derivatives of hexanol (C6H11OH).
A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)
Thirteen-carbon butene cyclohexene degradation products formed by the cleavage of CAROTENOIDS. They contribute to the flavor of some FRUIT. Ionone should not be confused with the similarly named ionol.
Glycoprotein moieties on the surfaces of cell membranes that bind concanavalin A selectively; the number and location of the sites depends on the type and condition of the cell.
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
3-Acetyl-5-sec-butyl-4-hydroxy-3-pyrrolin-2-one. A metabolite found in a strain of the fungus Alternaria tenuis Auct. which functions as an antibiotic with antiviral and antineoplastic properties, and may also act as a mycotoxin.
A steroid of interest both because its biosynthesis in FUNGI is a target of ANTIFUNGAL AGENTS, notably AZOLES, and because when it is present in SKIN of animals, ULTRAVIOLET RAYS break a bond to result in ERGOCALCIFEROL.
Established cell cultures that have the potential to propagate indefinitely.
Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.
The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.
A 34-amino acid polypeptide antibiotic produced by Streptococcus lactis. It has been used as a food preservative in canned fruits and vegetables, and cheese.
A physical property showing different values in relation to the direction in or along which the measurement is made. The physical property may be with regard to thermal or electric conductivity or light refraction. In crystallography, it describes crystals whose index of refraction varies with the direction of the incident light. It is also called acolotropy and colotropy. The opposite of anisotropy is isotropy wherein the same values characterize the object when measured along axes in all directions.
A group of condensed ring hydrocarbons.
A family of enzymes that catalyze the stereoselective, regioselective, or chemoselective syn-dehydrogenation reactions. They function by a mechanism that is linked directly to reduction of molecular OXYGEN.
The rate dynamics in chemical or physical systems.
The tendency of a gas or solute to pass from a point of higher pressure or concentration to a point of lower pressure or concentration and to distribute itself throughout the available space. Diffusion, especially FACILITATED DIFFUSION, is a major mechanism of BIOLOGICAL TRANSPORT.
An autosomal recessive disorder of lipid metabolism. It is caused by mutation of the microsomal triglyceride transfer protein that catalyzes the transport of lipids (TRIGLYCERIDES; CHOLESTEROL ESTERS; PHOSPHOLIPIDS) and is required in the secretion of BETA-LIPOPROTEINS (low density lipoproteins or LDL). Features include defective intestinal lipid absorption, very low serum cholesterol level, and near absent LDL.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Membrane proteins whose primary function is to facilitate the transport of molecules across a biological membrane. Included in this broad category are proteins involved in active transport (BIOLOGICAL TRANSPORT, ACTIVE), facilitated transport and ION CHANNELS.
The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
Derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to an ethanolamine moiety. Complete hydrolysis yields 1 mole of glycerol, phosphoric acid and ethanolamine and 2 moles of fatty acids.
Physiological processes in biosynthesis (anabolism) and degradation (catabolism) of LIPIDS.
The two lipoprotein layers in the MITOCHONDRION. The outer membrane encloses the entire mitochondrion and contains channels with TRANSPORT PROTEINS to move molecules and ions in and out of the organelle. The inner membrane folds into cristae and contains many ENZYMES important to cell METABOLISM and energy production (MITOCHONDRIAL ATP SYNTHASE).
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
Glycoproteins found on the membrane or surface of cells.
An enzyme that catalyzes the active transport system of sodium and potassium ions across the cell wall. Sodium and potassium ions are closely coupled with membrane ATPase which undergoes phosphorylation and dephosphorylation, thereby providing energy for transport of these ions against concentration gradients.
Differential thermal analysis in which the sample compartment of the apparatus is a differential calorimeter, allowing an exact measure of the heat of transition independent of the specific heat, thermal conductivity, and other variables of the sample.
Microscopy of specimens stained with fluorescent dye (usually fluorescein isothiocyanate) or of naturally fluorescent materials, which emit light when exposed to ultraviolet or blue light. Immunofluorescence microscopy utilizes antibodies that are labeled with fluorescent dye.
Cell membranes associated with synapses. Both presynaptic and postsynaptic membranes are included along with their integral or tightly associated specializations for the release or reception of transmitters.
A class of sphingolipids found largely in the brain and other nervous tissue. They contain phosphocholine or phosphoethanolamine as their polar head group so therefore are the only sphingolipids classified as PHOSPHOLIPIDS.
Derivatives of PHOSPHATIDYLCHOLINES obtained by their partial hydrolysis which removes one of the fatty acid moieties.
Cyclic GLUCANS consisting of seven (7) glucopyranose units linked by 1,4-glycosidic bonds.
Synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of PULMONARY SURFACTANTS.
A nitrogen-free class of lipids present in animal and particularly plant tissues and composed of one mole of glycerol and 1 or 2 moles of phosphatidic acid. Members of this group differ from one another in the nature of the fatty acids released on hydrolysis.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
Property of membranes and other structures to permit passage of light, heat, gases, liquids, metabolites, and mineral ions.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Proteins found in any species of bacterium.
A specific monosialoganglioside that accumulates abnormally within the nervous system due to a deficiency of GM1-b-galactosidase, resulting in GM1 gangliosidosis.
A four carbon linear hydrocarbon that has a hydroxy group at position 1.
Elements of limited time intervals, contributing to particular results or situations.
The non-genetic biological changes of an organism in response to challenges in its ENVIRONMENT.
A MANNOSE/GLUCOSE binding lectin isolated from the jack bean (Canavalia ensiformis). It is a potent mitogen used to stimulate cell proliferation in lymphocytes, primarily T-lymphocyte, cultures.
Cholesterol substituted in any position by a keto moiety. The 7-keto isomer inhibits 3-hydroxy-3-methylglutaryl-CoA reductase activity and inhibits cholesterol uptake in the coronary arteries and aorta in vitro.
A synthetic phospholipid used in liposomes and lipid bilayers for the study of biological membranes.
A group of compounds that are derivatives of octadecanoic acid which is one of the most abundant fatty acids found in animal lipids. (Stedman, 25th ed)
A cytotoxic member of the CYTOCHALASINS.
The property of emitting radiation while being irradiated. The radiation emitted is usually of longer wavelength than that incident or absorbed, e.g., a substance can be irradiated with invisible radiation and emit visible light. X-ray fluorescence is used in diagnosis.
A group of fatty acids that contain 18 carbon atoms and a double bond at the omega 9 carbon.
Detergent-insoluble CELL MEMBRANE components. They are enriched in SPHINGOLIPIDS and CHOLESTEROL and clustered with glycosyl-phosphatidylinositol (GPI)-anchored proteins.
The thermodynamic interaction between a substance and WATER.
The process of moving proteins from one cellular compartment (including extracellular) to another by various sorting and transport mechanisms such as gated transport, protein translocation, and vesicular transport.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
The process by which semen is kept viable outside of the organism from which it was derived (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism).
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.

Stomatocytosis is absent in "stomatin"-deficient murine red blood cells. (1/1645)

To examine the relationship between erythrocyte membrane protein 7. 2b deficiency and the hemolytic anemia of human hereditary stomatocytosis, we created 7.2b knock-out mice by standard gene targeting approaches. Immunoblots showed that homozygous knock-out mice completely lacked erythrocyte protein 7.2b. Despite the absence of protein 7.2b, there was no hemolytic anemia and mouse red blood cells (RBCs) were normal in morphology, cell indices, hydration status, monovalent cation content, and ability to translocate lipids. The absence of the phenotype of hereditary stomatocytosis implies that protein 7.2b deficiency plays no direct role in the etiology of this disorder and casts doubt on the previously proposed role of this protein as a mediator of cation transport in RBC.  (+info)

Vesicle deformation by an axial load: from elongated shapes to tethered vesicles. (2/1645)

A sufficiently large force acting on a single point of the fluid membrane of a flaccid phospholipid vesicle is known to cause the formation of a narrow bilayer tube (tether). We analyze this phenomenon by means of general mathematical methods allowing us to determine the shapes of strongly deformed vesicles including their stability. Starting from a free vesicle with an axisymmetric, prolate equilibrium shape, we consider an axial load that pulls (or pushes) the poles of the vesicle apart. Arranging the resulting shapes of strained vesicles in dependence of the axial deformation and of the area difference of monolayers, phase diagrams of stable shapes are presented comprising prolate shapes with or without equatorial mirror symmetry. For realistic values of membrane parameters, we study the force-extension relation of strained vesicles, and we demonstrate in detail how the initially elongated shape of an axially stretched vesicle transforms into a shape involving a membrane tether. This tethering transition may be continuous or discontinuous. If the free vesicle is mirror symmetric, the mirror symmetry is broken as the tether forms. The stability analysis of tethered shapes reveals that, for the considered vesicles, the stable shape is always asymmetric (polar), i.e., it involves only a single tether on one side of the main vesicle body. Although a bilayer tube formed from a closed vesicle is not an ideal cylinder, we show that, for most practical purposes, it is safe to assume a cylindrical geometry of tethers. This analysis is supplemented by the documentation of a prototype experiment supporting our theoretical predictions. It shows that the currently accepted model for the description of lipid-bilayer elasticity (generalized bilayer couple model) properly accounts for the tethering phenomenon.  (+info)

Monte Carlo simulation of two-component bilayers: DMPC/DSPC mixtures. (3/1645)

In this paper, we describe a relatively simple lattice model of a two-component, two-state phospholipid bilayer. Application of Monte Carlo methods to this model permits simulation of the observed excess heat capacity versus temperature curves of dimyristoylphosphatidylcholine (DMPC)/distearoylphosphatidylcholine (DSPC) mixtures as well as the lateral distributions of the components and properties related to these distributions. The analysis of the bilayer energy distribution functions reveals that the gel-fluid transition is a continuous transition for DMPC, DSPC, and all DMPC/DSPC mixtures. A comparison of the thermodynamic properties of DMPC/DSPC mixtures with the configurational properties shows that the temperatures characteristics of the configurational properties correlate well with the maxima in the excess heat capacity curves rather than with the onset and completion temperatures of the gel-fluid transition. In the gel-fluid coexistence region, we also found excellent agreement between the threshold temperatures at different system compositions detected in fluorescence recovery after photobleaching experiments and the temperatures at which the percolation probability of the gel clusters is 0.36. At every composition, the calculated mole fraction of gel state molecules at the fluorescence recovery after photobleaching threshold is 0.34 and, at the percolation threshold of gel clusters, it is 0.24. The percolation threshold mole fraction of gel or fluid lipid depends on the packing geometry of the molecules and the interchain interactions. However, it is independent of temperature, system composition, and state of the percolating cluster.  (+info)

Cell membrane dynamics and the induction of apoptosis by lipid compounds. (4/1645)

To investigate the induction of apoptosis by some lipid compounds which are a potent inducer of apoptosis, the plasma membrane fluidity of U937 cells was measured using the fluorescent probe, pyrene. The increase of the membrane fluidity was observed immediately after the treatment of cells with lipid inducers. We also found that the trigger of apoptosis was pulled within 30 min after treatment. Data from the dynamic light scattering experiment indicated that lipid inducers were dissolved to form the emulsion. At the very early stage of apoptosis, possibly, the well-controlled transfer of lipid inducers from the emulsion to the lipid layer of cells can bring about the increase of membrane dynamics which might lead to the induction of apoptosis.  (+info)

The interaction of ubiquinone-3 with phospholipid membranes. (5/1645)

The effects of ubiquinone-3 (UQ) on dipalmitoylphosphatidylcholine (DPPC) membrane were studied by surface monolayer, differential scanning calorimetry (DSC) and fluorescence techniques. DPPC and UQ are proved to be freely miscible in the mixed monolayer at an air/water interface, and to be partially miscible in bulk phase, i.e. bilayer and solid phase. There is a condensing interaction between UQ and DPPC in the UQ/DPPC mixed monolayers. The solubility of UQ in the DPPC is about 20 mole% and the solubility of DPPC in UQ is about 10 mole%. The membrane fluidity of DPPC was increased by the addition of UQ and the phase transition temperature was decreased.  (+info)

Interaction of tumor and normal blood cells with ethylene oxide and propylene oxide block copolymers. (6/1645)

Ethylene oxide and propylene oxide block copolymers (pluronics) are widely known as agents that promote drug penetration across biological barriers. We have studied the interaction of normal and malignant blood cells with pluronics L61 and P85 that have different hydrophobicity. SP2/0 myeloma cells accumulated pluronics while normal cells adsorb most of the polymer on the surface. Interaction of pluronics with cells resulted in drastic changes of membrane microviscosity. Tumor cell membrane microviscosity decreased after pluronics adsorption, in contrast to normal cells, whose membrane microviscosity was enhanced. We suppose that sensitivity of tumor cell membrane microviscosity to the pluronics action correlates with its permeability for molecular substances.  (+info)

The yeast multidrug resistance pump, Pdr5p, confers reduced drug resistance in erg mutants of Saccharomyces cerevisiae. (7/1645)

Mutants of Saccharomyces cerevisiae bearing lesions in the ergosterol biosynthetic pathway exhibit a pleiotropic drug-sensitive phenotype. This has been reported to result from an increased permeability of the membranes of the mutant strains to different drugs. As disruption of the yeast multidrug resistance protein, Pdr5p, results in a similar pleiotropic drug-sensitive phenotype, the possibility that Pdr5p may be functioning with a reduced efficiency in these altered sterol backgrounds was examined. To do this, the function of Pdr5p in isogenic strains of S. cerevisiae that have disruptions in the late stages of the ergosterol biosynthesis pathway (ERG6, ERG2, ERG3, ERG4) was studied. A reduced ability of Pdr5p to confer resistance to different drugs in these strains was observed, which did not appear to be dependent solely on the permeability of the membrane towards the drug. A simultaneous examination was made of how the lipid composition might be altering the efficiency of Pdr5p by similar studies in strains lacking phosphatidylserine synthase (encoded by CHO1). The results indicated that the drug sensitivity of the erg strains is, to a significant extent, a result of the reduced efficiency of the Pdr5p efflux pump, and that the membrane environment plays an important role in determining the drug resistance conferred by Pdr5p.  (+info)

Induction of acetylcholinesterase release from erythrocytes in the presence of liposomes. (8/1645)

When human erythrocytes are incubated with liposomes, the release of acetylcholinesterase (AChE) occurs following an induction period [Cook et al. (1980) Biochemistry 19, 4601-4607]. However, the mechanism of the induction has not been elucidated. We examined the relationships among the lipid transfer from liposomes to erythrocytes, the morphological change of erythrocytes, the fluidity of the erythrocyte membrane and the start of AChE release. The AChE release into the liposomes and into shed-vesicle fractions started simultaneously after an induction period. The morphological index (MI) of erythrocytes was approximately 2.8 at the beginning of the release, regardless of the induction period. AChE was not released from the erythrocytes of index 2.8 even in the presence of liposomes if the MI remained at 2.8. Therefore, for the release, erythrocytes needed a further increase of the MI from 2.8. As the rate of lipid transfer increased, the induction period became shorter. No significant lipid release from erythrocytes was detected during the induction period. The initiation of the AChE release was not simply affected by the change in the membrane fluidity of erythrocytes upon interaction with liposomes. These results first demonstrate that AChE release into the shed-vesicle and liposome fractions is triggered by a further increase of the MI from 2.8, which is induced by lipid transfer from liposomes to erythrocytes.  (+info)

Membrane lipids are a type of lipid molecule that are essential components of cell membranes. They are composed of fatty acids and glycerol, and are responsible for maintaining the structure and function of cell membranes. There are several types of membrane lipids, including phospholipids, glycolipids, and cholesterol. Phospholipids are the most abundant type of membrane lipid and are responsible for forming the basic structure of cell membranes. They consist of a hydrophilic (water-loving) head and two hydrophobic (water-fearing) tails, which allow them to spontaneously form a bilayer in an aqueous environment. Glycolipids are another type of membrane lipid that are composed of a fatty acid chain and a carbohydrate group. They are found on the surface of cell membranes and play a role in cell recognition and signaling. Cholesterol is a third type of membrane lipid that is important for maintaining the fluidity and stability of cell membranes. It is also involved in the regulation of membrane protein function. Membrane lipids play a crucial role in many cellular processes, including cell signaling, nutrient transport, and cell division. They are also important for maintaining the integrity and function of cell membranes, which are essential for the survival of cells.

Diphenylhexatriene (DPH) is a fluorescent dye that is commonly used in the medical field to study the function of cell membranes. It is a small molecule that can easily penetrate cell membranes and become incorporated into the lipid bilayer. Once inside the membrane, DPH emits fluorescence, which can be detected and measured using a fluorescence microscope or other imaging techniques. DPH is often used to study the fluidity of cell membranes, which is an important factor in many cellular processes. For example, changes in membrane fluidity can affect the function of membrane proteins, the transport of molecules across the membrane, and the overall integrity of the cell. By measuring the fluorescence of DPH in different cell types or under different conditions, researchers can gain insights into how membrane fluidity is regulated and how it contributes to cellular function. In addition to its use in basic research, DPH has also been used in clinical settings to study diseases that affect cell membranes, such as atherosclerosis and neurodegenerative disorders.

The cell membrane, also known as the plasma membrane, is a thin, flexible barrier that surrounds and encloses the cell. It is composed of a phospholipid bilayer, which consists of two layers of phospholipid molecules arranged tail-to-tail. The hydrophobic tails of the phospholipids face inward, while the hydrophilic heads face outward, forming a barrier that separates the inside of the cell from the outside environment. The cell membrane also contains various proteins, including channels, receptors, and transporters, which allow the cell to communicate with its environment and regulate the movement of substances in and out of the cell. In addition, the cell membrane is studded with cholesterol molecules, which help to maintain the fluidity and stability of the membrane. The cell membrane plays a crucial role in maintaining the integrity and function of the cell, and it is involved in a wide range of cellular processes, including cell signaling, cell adhesion, and cell division.

Benzyl alcohol is a colorless liquid with a sweet, fruity odor. It is a type of alcohol that is derived from benzene, a chemical compound that is found in many plants and is also produced synthetically. In the medical field, benzyl alcohol is used as a preservative in a variety of medications and other products, such as eye drops, nasal sprays, and topical creams. It is also used as a solvent and a fragrance in some products. However, benzyl alcohol can be toxic if ingested in large amounts, and it can cause skin irritation and other adverse reactions in some people. As a result, it is important to use benzyl alcohol-containing products carefully and to follow the instructions on the label.

Phospholipids are a type of lipid molecule that are essential components of cell membranes in living organisms. They are composed of a hydrophilic (water-loving) head and two hydrophobic (water-fearing) tails, which together form a bilayer structure that separates the interior of the cell from the external environment. Phospholipids are important for maintaining the integrity and fluidity of cell membranes, and they also play a role in cell signaling and the transport of molecules across the membrane. They are found in all types of cells, including animal, plant, and bacterial cells, and are also present in many types of lipoproteins, which are particles that transport lipids in the bloodstream. In the medical field, phospholipids are used in a variety of applications, including as components of artificial cell membranes for research purposes, as components of liposomes (small vesicles that can deliver drugs to specific cells), and as ingredients in dietary supplements and other health products. They are also the subject of ongoing research in the fields of nutrition, metabolism, and disease prevention.

"Laurates" is not a commonly used term in the medical field. It is possible that you may be referring to "lauric acid," which is a fatty acid found in coconut oil and other plant oils. Lauric acid has been studied for its potential health benefits, including its antimicrobial properties and its ability to boost the immune system. However, more research is needed to fully understand the effects of lauric acid on human health.

Fatty acids are organic compounds that are composed of a long chain of carbon atoms with hydrogen atoms attached to them. They are a type of lipid, which are molecules that are insoluble in water but soluble in organic solvents. Fatty acids are an important source of energy for the body and are also used to synthesize other important molecules, such as hormones and cell membranes. In the medical field, fatty acids are often studied in relation to their role in various diseases, such as cardiovascular disease, diabetes, and obesity. They are also used in the development of new drugs and therapies.

2-Naphthylamine is a chemical compound that is used in the production of dyes, pigments, and other industrial chemicals. It is also a known human carcinogen, and exposure to it has been linked to an increased risk of bladder cancer. In the medical field, 2-naphthylamine is not typically used as a therapeutic agent, but it may be encountered in the context of occupational health and safety, as well as in the investigation of environmental pollutants.

In the medical field, cell membrane permeability refers to the ability of molecules to pass through the cell membrane. The cell membrane is a selectively permeable barrier that regulates the movement of substances in and out of the cell. Some molecules, such as water and gases, can pass through the cell membrane freely, while others require specific transport proteins to cross the membrane. The permeability of the cell membrane is important for maintaining the proper balance of ions and molecules inside and outside the cell, which is essential for cell function and survival. Abnormalities in cell membrane permeability can lead to a variety of medical conditions, including fluid and electrolyte imbalances, nutrient deficiencies, and the development of diseases such as cancer and neurodegenerative disorders. Therefore, understanding the mechanisms that regulate cell membrane permeability is an important area of research in medicine.

Cholesterol is a waxy, fat-like substance that is produced by the liver and is also found in some foods. It is an essential component of cell membranes and is necessary for the production of hormones, bile acids, and vitamin D. However, high levels of cholesterol in the blood can increase the risk of developing heart disease and stroke. There are two main types of cholesterol: low-density lipoprotein (LDL) cholesterol, which is often referred to as "bad" cholesterol because it can build up in the walls of arteries and lead to plaque formation, and high-density lipoprotein (HDL) cholesterol, which is often referred to as "good" cholesterol because it helps remove excess cholesterol from the bloodstream and transport it back to the liver for processing.

In the medical field, lipid bilayers refer to the two layers of phospholipid molecules that form the basic structure of cell membranes. The lipid bilayer is composed of a hydrophilic (water-loving) head and a hydrophobic (water-fearing) tail. The hydrophilic heads face outward, towards the aqueous environment of the cell, while the hydrophobic tails face inward, towards each other. This arrangement creates a barrier that separates the inside of the cell from the outside environment, while also allowing for the selective passage of molecules in and out of the cell. The lipid bilayer is essential for maintaining the integrity and function of cells, and is involved in a wide range of cellular processes, including cell signaling, metabolism, and transport.

Stearates are esters of stearic acid, a saturated fatty acid with 18 carbon atoms. They are commonly used in the medical field as emollients, lubricants, and surfactants. In pharmaceuticals, stearates are used as diluents, binders, and lubricants in the production of tablets and capsules. They can also be used as carriers for drug delivery systems. In dermatology, stearates are used as moisturizers and emollients to soften and soothe dry, rough skin. They can also be used as ingredients in skin care products to improve the texture and appearance of the skin. In dentistry, stearates are used as lubricants in dental impressions and as ingredients in toothpaste to improve the texture and flavor of the product. Overall, stearates are a versatile and widely used ingredient in the medical field due to their emollient, lubricant, and surfactant properties.

Phosphatidylcholines (PCs) are a type of phospholipid, which are essential components of cell membranes. They are composed of a glycerol backbone, two fatty acid chains, and a phosphate group, with a choline molecule attached to the phosphate group. In the medical field, phosphatidylcholines are often used as a dietary supplement or in various medical treatments. They have been shown to have a number of potential health benefits, including improving liver function, reducing inflammation, and improving cognitive function. Phosphatidylcholines are also used in some medical treatments, such as liposuction, where they are injected into the fat cells to help break them down and remove them from the body. They are also used in some types of chemotherapy to help reduce side effects and improve treatment outcomes.

In the medical field, spin labels are a type of molecular probe that are used to study the dynamics of molecules in living systems. Spin labels are small molecules that contain a nucleus with an odd number of protons, such as carbon-13 or nitrogen-15, which gives rise to a magnetic moment. When a spin label is introduced into a sample, it can be detected using nuclear magnetic resonance (NMR) spectroscopy. Spin labels are often used to study the movement of molecules within cells or tissues, as well as the interactions between molecules. They can be attached to specific molecules of interest, such as proteins or lipids, and their motion can be tracked over time using NMR spectroscopy. This information can provide insights into the function and behavior of these molecules, as well as the underlying mechanisms of various diseases. Overall, spin labels are a valuable tool in the medical field for studying the dynamics of molecules in living systems, and they have a wide range of applications in areas such as drug discovery, cell biology, and neuroscience.

Benzyl alcohols are a class of organic compounds that contain a benzene ring and a hydroxyl group (-OH) attached to one of the carbon atoms in the ring. They are commonly used as preservatives in medical and pharmaceutical products, as well as in cosmetics and personal care products. In the medical field, benzyl alcohols are used as antiseptics and disinfectants to prevent the growth of microorganisms on skin and surfaces. They are also used as solvents for other active ingredients in medical products, such as topical creams and ointments. Benzyl alcohols are generally considered safe for use in medical products, but they can cause skin irritation or allergic reactions in some people. They are also flammable and should be handled with care.

In the medical field, "Fatty Acids, Unsaturated" refers to a type of fatty acid that contains one or more double bonds in the carbon chain. Unsaturated fatty acids are classified into two categories: monounsaturated fatty acids (MUFAs) and polyunsaturated fatty acids (PUFAs). MUFAs have one double bond in their carbon chain, while PUFAs have two or more double bonds. Unsaturated fatty acids are considered healthier than saturated fatty acids because they can lower cholesterol levels, reduce the risk of heart disease, and improve blood pressure. Some examples of unsaturated fatty acids include oleic acid (a MUFA found in olive oil), linoleic acid (a PUFA found in vegetable oils), and alpha-linolenic acid (an omega-3 PUFA found in fish oil). In medical contexts, the consumption of unsaturated fatty acids is often recommended as part of a healthy diet to promote cardiovascular health and reduce the risk of chronic diseases.

In the medical field, alcohols refer to a group of organic compounds that contain a hydroxyl (-OH) group attached to a carbon atom. Alcohols are commonly used as solvents, disinfectants, and antiseptics in the medical field. They are also used as active ingredients in many medications, such as rubbing alcohol, which is used to clean wounds and skin surfaces. There are different types of alcohols, including primary alcohols, secondary alcohols, and tertiary alcohols, which differ in the number of carbon atoms bonded to the hydroxyl group. Some common examples of alcohols used in the medical field include ethanol, isopropyl alcohol, and methanol. However, it is important to note that some alcohols, such as methanol, can be toxic and can cause serious health problems if ingested or inhaled in high concentrations. Therefore, proper handling and storage of alcohols are essential to prevent accidental exposure and ensure their safe use in the medical field.

The basement membrane is a thin layer of connective tissue that separates the epithelial cells from the underlying connective tissue in many organs and tissues in the body. It is composed of a basement membrane zone (BMZ), which is a dense extracellular matrix, and the lamina propria, which is a loose connective tissue layer. The basement membrane plays an important role in maintaining the integrity of tissues and organs, as well as in regulating the exchange of substances between the epithelial cells and the underlying connective tissue. It is also involved in the development and differentiation of cells, and in the formation of blood vessels and nerves. In the medical field, the basement membrane is often studied in relation to various diseases and conditions, such as cancer, autoimmune disorders, and connective tissue diseases. It is also an important component of many laboratory tests, such as skin biopsies and kidney biopsies, which are used to diagnose and monitor these conditions.

In the medical field, "cold temperature" refers to a body temperature that is below the normal range of 98.6°F (37°C). This can be caused by a variety of factors, including exposure to cold temperatures, certain medical conditions, or the use of certain medications. A person with a cold temperature may experience symptoms such as shivering, feeling weak or fatigued, and having difficulty concentrating. In severe cases, a cold temperature can lead to hypothermia, which is a life-threatening condition characterized by a dangerously low body temperature. Medical professionals may use various methods to measure body temperature, including oral thermometers, rectal thermometers, and ear thermometers. If a person's body temperature is found to be below the normal range, they may be treated with measures to raise their body temperature, such as warm blankets or heating pads, and in severe cases, may require hospitalization for further treatment.

Hexanols are a group of organic compounds that contain six carbon atoms and one or more hydroxyl (-OH) groups. They are alcohols, which means they have a hydroxyl group attached to a carbon atom. Hexanols are commonly used in the medical field as solvents, antiseptics, and disinfectants. They are also used in the production of pharmaceuticals and personal care products. Some hexanols, such as 1-hexanol and 2-hexanol, have been shown to have antimicrobial properties and are used as preservatives in medical devices and pharmaceuticals. However, hexanols can also be toxic if ingested or inhaled in large quantities, so they must be handled with care in the medical field.

Lipids are a diverse group of organic compounds that are insoluble in water but soluble in organic solvents such as ether or chloroform. They are an essential component of cell membranes and play a crucial role in energy storage, insulation, and signaling in the body. In the medical field, lipids are often measured as part of a routine blood test to assess an individual's risk for cardiovascular disease. The main types of lipids that are measured include: 1. Total cholesterol: This includes both low-density lipoprotein (LDL) cholesterol, which is often referred to as "bad" cholesterol, and high-density lipoprotein (HDL) cholesterol, which is often referred to as "good" cholesterol. 2. Triglycerides: These are a type of fat that is stored in the body and can be converted into energy when needed. 3. Phospholipids: These are a type of lipid that is a major component of cell membranes and helps to regulate the flow of substances in and out of cells. 4. Steroids: These are a type of lipid that includes hormones such as testosterone and estrogen, as well as cholesterol. Abnormal levels of lipids in the blood can increase the risk of cardiovascular disease, including heart attack and stroke. Therefore, monitoring and managing lipid levels is an important part of maintaining overall health and preventing these conditions.

Norisoprenoids are a group of organic compounds that are derived from the metabolic pathway of isoprenoids. They are a subclass of terpenoids, which are a large and diverse group of compounds that are found in many plants, animals, and microorganisms. Norisoprenoids are important in the medical field because they have a variety of biological activities, including anti-inflammatory, anti-cancer, and anti-viral effects. Some norisoprenoids have been shown to have potential therapeutic applications in the treatment of a range of diseases, including cancer, cardiovascular disease, and viral infections. One example of a norisoprenoid is the compound farnesol, which is produced by many types of bacteria and has been shown to have anti-inflammatory and anti-cancer effects. Another example is the compound xanthohumol, which is found in hops and has been shown to have anti-cancer and anti-inflammatory effects. Overall, norisoprenoids are an important class of compounds that have a variety of potential therapeutic applications in the medical field.

Receptors, Concanavalin A (ConA) are a type of protein receptors found on the surface of certain cells in the immune system. ConA is a lectin, a type of protein that binds to specific carbohydrate structures on the surface of cells. When ConA binds to its target cells, it triggers a series of signaling pathways that can activate immune cells and promote an immune response. ConA receptors are particularly important in the study of T cell activation and have been used as a tool to study the function of T cells in various diseases and conditions.

Calcium is a chemical element with the symbol Ca and atomic number 20. It is a vital mineral for the human body and is essential for many bodily functions, including bone health, muscle function, nerve transmission, and blood clotting. In the medical field, calcium is often used to diagnose and treat conditions related to calcium deficiency or excess. For example, low levels of calcium in the blood (hypocalcemia) can cause muscle cramps, numbness, and tingling, while high levels (hypercalcemia) can lead to kidney stones, bone loss, and other complications. Calcium supplements are often prescribed to people who are at risk of developing calcium deficiency, such as older adults, vegetarians, and people with certain medical conditions. However, it is important to note that excessive calcium intake can also be harmful, and it is important to follow recommended dosages and consult with a healthcare provider before taking any supplements.

Tenuazonic acid is a mycotoxin produced by several species of fungi, including Alternaria alternata, Cladosporium cladosporioides, and Phoma herbarum. It is commonly found in crops such as wheat, barley, oats, and corn, as well as in other plants and foods. In the medical field, tenuazonic acid has been associated with a range of adverse health effects, including gastrointestinal symptoms, liver damage, and neurotoxicity. It has also been linked to the development of certain types of cancer, such as liver cancer and lung cancer. Tenuazonic acid is considered a potential food safety concern, as it can accumulate in crops and food products, particularly in areas with high levels of fungal contamination. To minimize the risk of exposure to tenuazonic acid, it is important to practice good agricultural and food handling practices, such as proper storage and handling of crops and food products, and regular monitoring for fungal contamination.

Ergosterol is a type of sterol that is found in the cell membranes of fungi and some protists. It is an essential component of the fungal cell membrane, playing a role in maintaining the membrane's structure and fluidity. In the medical field, ergosterol is often used as a diagnostic marker for fungal infections, as it is not present in human cells. It is also used as a target for antifungal drugs, as many antifungal agents work by inhibiting ergosterol biosynthesis in fungal cells. In addition to its role in fungal cell membranes, ergosterol has been studied for its potential therapeutic applications in other areas of medicine. For example, it has been shown to have anti-inflammatory and anti-cancer properties, and it is being investigated as a potential treatment for a variety of diseases, including cancer, Alzheimer's disease, and multiple sclerosis.

In the medical field, a cell line refers to a group of cells that have been derived from a single parent cell and have the ability to divide and grow indefinitely in culture. These cells are typically grown in a laboratory setting and are used for research purposes, such as studying the effects of drugs or investigating the underlying mechanisms of diseases. Cell lines are often derived from cancerous cells, as these cells tend to divide and grow more rapidly than normal cells. However, they can also be derived from normal cells, such as fibroblasts or epithelial cells. Cell lines are characterized by their unique genetic makeup, which can be used to identify them and compare them to other cell lines. Because cell lines can be grown in large quantities and are relatively easy to maintain, they are a valuable tool in medical research. They allow researchers to study the effects of drugs and other treatments on specific cell types, and to investigate the underlying mechanisms of diseases at the cellular level.

Hemolysis is the breakdown of red blood cells (RBCs) in the bloodstream. This process can occur due to various factors, including mechanical stress, exposure to certain medications or toxins, infections, or inherited genetic disorders. When RBCs are damaged or destroyed, their contents, including hemoglobin, are released into the bloodstream. Hemoglobin is a protein that carries oxygen from the lungs to the body's tissues and carbon dioxide from the tissues back to the lungs. When hemoglobin is released into the bloodstream, it can cause the blood to appear dark brown or black, a condition known as hemoglobinuria. Hemolysis can lead to a variety of symptoms, including jaundice (yellowing of the skin and eyes), fatigue, shortness of breath, abdominal pain, and dark urine. In severe cases, hemolysis can cause life-threatening complications, such as kidney failure or shock. Treatment for hemolysis depends on the underlying cause. In some cases, treatment may involve medications to slow down the breakdown of RBCs or to remove excess hemoglobin from the bloodstream. In other cases, treatment may involve blood transfusions or other supportive therapies to manage symptoms and prevent complications.

Nisin is a natural antibiotic produced by certain strains of the bacterium Lactococcus lactis. It is commonly used as a food preservative to prevent the growth of spoilage bacteria and fungi in a variety of food products, including cheese, meat, and dairy products. In the medical field, nisin has been studied for its potential use in treating bacterial infections, particularly those caused by antibiotic-resistant strains of bacteria. Some research has suggested that nisin may be effective against a range of bacterial pathogens, including Staphylococcus aureus, Streptococcus pneumoniae, and Escherichia coli. However, more research is needed to fully understand the potential therapeutic applications of nisin in medicine. While nisin is generally considered safe for human consumption, it can cause allergic reactions in some people and may interact with certain medications. As with any medical treatment, the use of nisin should be carefully considered and monitored by a healthcare professional.

In the medical field, anisotropy refers to a property of a material or tissue that has different properties or behavior in different directions. This can be observed in various medical imaging techniques, such as magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI). For example, in MRI, anisotropy can be seen in the diffusion of water molecules within tissues. Water molecules tend to move more easily in certain directions than in others, depending on the structure of the tissue. This anisotropy can be measured using DTI, which provides information about the orientation and organization of fibers within the brain and other tissues. Anisotropy can also be observed in the electrical conductivity of tissues, which can affect the propagation of electrical signals within the body. For example, the heart muscle is anisotropic, with different electrical conductivity in different directions, which allows for the coordinated contraction of the heart. Overall, anisotropy is an important concept in medical imaging and can provide valuable information about the structure and function of tissues within the body.

I'm sorry, but I couldn't find any specific medical term or definition related to "Pyrenes." It's possible that you may have misspelled the word or that it is not commonly used in the medical field. If you could provide more context or information about where you heard or saw this term, I may be able to provide a more accurate answer.

Fatty acid desaturases are a group of enzymes that catalyze the removal of hydrogen atoms from the carbon-carbon double bonds in fatty acids. This process, known as desaturation, increases the degree of unsaturation of the fatty acid, resulting in the formation of a double bond in a different position. Desaturases are important in the metabolism of fatty acids, as they play a role in the synthesis of essential fatty acids, which cannot be produced by the body and must be obtained through the diet. There are several different types of fatty acid desaturases, each of which catalyzes the desaturation of a specific type of fatty acid. These enzymes are found in a variety of organisms, including plants, animals, and microorganisms.

Abetalipoproteinemia, also known as hypobetalipoproteinemia, is a rare genetic disorder that affects the production of lipoproteins, which are complex particles that transport fats and cholesterol in the bloodstream. Specifically, individuals with abetalipoproteinemia have low levels of low-density lipoprotein (LDL) cholesterol and very low levels of high-density lipoprotein (HDL) cholesterol, as well as an absence of apolipoprotein B (apoB), a protein that is essential for the production of these lipoproteins. As a result of this deficiency, individuals with abetalipoproteinemia may experience a range of symptoms, including diarrhea, malabsorption of fats and fat-soluble vitamins (such as vitamin A, D, E, and K), and anemia due to the lack of vitamin B12 absorption. In severe cases, the condition can lead to liver damage and other complications. Abetalipoproteinemia is typically inherited in an autosomal recessive pattern, meaning that an individual must inherit two copies of the mutated gene (one from each parent) in order to develop the condition. It is estimated that abetalipoproteinemia affects fewer than 1 in 1 million people worldwide.

In the medical field, "Cells, Cultured" refers to cells that have been grown and maintained in a controlled environment outside of their natural biological context, typically in a laboratory setting. This process is known as cell culture and involves the isolation of cells from a tissue or organism, followed by their growth and proliferation in a nutrient-rich medium. Cultured cells can be derived from a variety of sources, including human or animal tissues, and can be used for a wide range of applications in medicine and research. For example, cultured cells can be used to study the behavior and function of specific cell types, to develop new drugs and therapies, and to test the safety and efficacy of medical products. Cultured cells can be grown in various types of containers, such as flasks or Petri dishes, and can be maintained at different temperatures and humidity levels to optimize their growth and survival. The medium used to culture cells typically contains a combination of nutrients, growth factors, and other substances that support cell growth and proliferation. Overall, the use of cultured cells has revolutionized medical research and has led to many important discoveries and advancements in the field of medicine.

Membrane transport proteins are proteins that span the cell membrane and facilitate the movement of molecules across the membrane. These proteins play a crucial role in maintaining the proper balance of ions and molecules inside and outside of cells, and are involved in a wide range of cellular processes, including nutrient uptake, waste removal, and signal transduction. There are several types of membrane transport proteins, including channels, carriers, and pumps. Channels are pore-forming proteins that allow specific ions or molecules to pass through the membrane down their concentration gradient. Carriers are proteins that bind to specific molecules and change shape to transport them across the membrane against their concentration gradient. Pumps are proteins that use energy to actively transport molecules across the membrane against their concentration gradient. Membrane transport proteins are essential for the proper functioning of cells and are involved in many diseases, including cystic fibrosis, sickle cell anemia, and certain types of cancer. Understanding the structure and function of these proteins is important for developing new treatments for these diseases.

Phosphatidylethanolamines (PEs) are a type of phospholipid that are found in cell membranes throughout the body. They are composed of a glycerol backbone, two fatty acid chains, and a phosphate group, with an ethanolamine group attached to the phosphate. PEs play a number of important roles in cell function, including maintaining the structure and fluidity of cell membranes, participating in signal transduction pathways, and serving as a source of energy for the cell. They are also involved in a number of cellular processes, such as cell growth and differentiation, and have been implicated in a number of diseases, including cancer and neurodegenerative disorders.

Membrane glycoproteins are proteins that are attached to the cell membrane through a glycosyl group, which is a complex carbohydrate. These proteins play important roles in cell signaling, cell adhesion, and cell recognition. They are involved in a wide range of biological processes, including immune response, cell growth and differentiation, and nerve transmission. Membrane glycoproteins can be classified into two main types: transmembrane glycoproteins, which span the entire cell membrane, and peripheral glycoproteins, which are located on one side of the membrane.

The Sodium-Potassium-Exchanging ATPase (Na+/K+-ATPase) is an enzyme that plays a crucial role in maintaining the electrochemical gradient across the cell membrane in animal cells. It is responsible for actively pumping three sodium ions (Na+) out of the cell and two potassium ions (K+) into the cell, using energy from ATP hydrolysis. This process is essential for many cellular functions, including nerve impulse transmission, muscle contraction, and the maintenance of cell volume. The Na+/K+-ATPase is also involved in the regulation of intracellular pH and the transport of other ions across the cell membrane. It is a ubiquitous enzyme found in all animal cells, and its dysfunction can lead to various diseases, including cardiac arrhythmias, muscle weakness, and neurological disorders.

Calorimetry, Differential Scanning is a technique used in the medical field to measure the heat capacity of a material or substance as a function of temperature. This technique is commonly used to study the thermal properties of biological samples, such as proteins, nucleic acids, and lipids, as well as to investigate the thermal stability of drugs and other therapeutic agents. In differential scanning calorimetry, a sample is placed in a sealed container and heated or cooled at a constant rate while the heat flow into or out of the sample is measured. The resulting curve of heat flow versus temperature provides information about the thermal transitions that occur within the sample, such as melting points, glass transitions, and phase transitions. This information can be used to study the structure and function of biological molecules, as well as to optimize the formulation and stability of drugs and other therapeutic agents.

Sphingomyelins are a type of sphingolipid, which are a class of lipids that are important components of cell membranes. They are composed of a sphingosine backbone, a fatty acid chain, and a phosphate group. In the medical field, sphingomyelins are often studied in relation to their role in the development and progression of various diseases, including cancer, neurodegenerative disorders, and cardiovascular disease. They are also important for maintaining the structure and function of cell membranes, and have been shown to play a role in the regulation of cell growth and differentiation.

Lysophosphatidylcholines (LPCs) are a type of phospholipid that are found in cell membranes and are involved in various cellular processes. They are characterized by the presence of a fatty acid chain attached to a glycerol backbone with a phosphate group and a choline head group. In the medical field, LPCs have been studied for their potential role in various diseases, including cancer, cardiovascular disease, and neurodegenerative disorders. They have been shown to modulate cell signaling pathways, affect cell proliferation and migration, and contribute to inflammation and oxidative stress. LPCs have also been used as a tool in diagnostic imaging and as a therapeutic agent in the treatment of certain diseases. For example, LPCs have been used as a contrast agent in magnetic resonance imaging (MRI) to visualize the blood-brain barrier and to detect brain tumors. They have also been investigated as a potential treatment for Alzheimer's disease, as they have been shown to improve cognitive function in animal models of the disease.

Beta-cyclodextrins (β-CD) are a type of cyclic oligosaccharide composed of seven glucose units linked by α-1,4-glycosidic bonds. They are commonly used in the medical field as a drug delivery system to improve the solubility, stability, and bioavailability of poorly water-soluble drugs. β-CD forms inclusion complexes with a wide range of hydrophobic molecules, including drugs, by encapsulating them within the hydrophobic cavity of the cyclodextrin molecule. This results in an increase in the solubility of the drug and a reduction in its toxicity. β-CD can also enhance the stability of drugs by protecting them from degradation and improving their shelf life. In addition to their use as drug delivery agents, β-CDs have also been used in medical imaging, as contrast agents for magnetic resonance imaging (MRI) and computed tomography (CT) scans. They have also been used in the treatment of certain medical conditions, such as inflammatory bowel disease and irritable bowel syndrome. Overall, β-CDs have a wide range of applications in the medical field, and their use is expected to continue to grow as researchers discover new ways to harness their unique properties.

1,2-Dipalmitoylphosphatidylcholine, also known as DPPC, is a type of phospholipid that is commonly found in cell membranes. It is a phospholipid that consists of a glycerol backbone, two fatty acid chains (palmitic acid), and a phosphate group attached to a choline headgroup. In the medical field, DPPC is often used as a component of liposomes, which are small, spherical vesicles that can encapsulate drugs and other molecules. Liposomes made with DPPC have been used in a variety of medical applications, including drug delivery, gene therapy, and imaging. DPPC has also been studied for its potential therapeutic effects in various diseases, including cancer, Alzheimer's disease, and multiple sclerosis. Some research has suggested that DPPC may have anti-inflammatory and neuroprotective properties, and it is being investigated as a potential treatment for these conditions.

Phosphatidylglycerols are a type of phospholipid, which are essential components of cell membranes. They are composed of a glycerol backbone, two fatty acid chains, and a phosphate group. Phosphatidylglycerols are found in all types of cells, but are particularly abundant in the membranes of certain organelles such as mitochondria and endoplasmic reticulum. In the medical field, phosphatidylglycerols have been studied for their potential role in various diseases and conditions. For example, changes in the levels of phosphatidylglycerols have been observed in certain types of cancer, and they may play a role in the development and progression of these diseases. Additionally, phosphatidylglycerols have been studied for their potential use as a diagnostic tool, as changes in their levels may indicate the presence of certain diseases or conditions.

Bacterial proteins are proteins that are synthesized by bacteria. They are essential for the survival and function of bacteria, and play a variety of roles in bacterial metabolism, growth, and pathogenicity. Bacterial proteins can be classified into several categories based on their function, including structural proteins, metabolic enzymes, regulatory proteins, and toxins. Structural proteins provide support and shape to the bacterial cell, while metabolic enzymes are involved in the breakdown of nutrients and the synthesis of new molecules. Regulatory proteins control the expression of other genes, and toxins can cause damage to host cells and tissues. Bacterial proteins are of interest in the medical field because they can be used as targets for the development of antibiotics and other antimicrobial agents. They can also be used as diagnostic markers for bacterial infections, and as vaccines to prevent bacterial diseases. Additionally, some bacterial proteins have been shown to have therapeutic potential, such as enzymes that can break down harmful substances in the body or proteins that can stimulate the immune system.

1-Butanol is a type of alcohol that is commonly used in the medical field as a solvent for various medications and as a component in some medications. It is a colorless, flammable liquid with a distinctive odor that is similar to that of ether. In the medical field, 1-butanol is often used as a solvent for medications that are not soluble in water, such as certain antibiotics and antifungal agents. It is also used as a component in some medications, such as certain eye drops and nasal sprays. In general, 1-butanol is considered to be safe for use in the medical field when used as directed. However, it is important to note that it can be toxic if ingested in large quantities, and it should be handled with care to avoid accidental exposure.

In the medical field, "Adaptation, Physiological" refers to the ability of an organism to adjust to changes in its environment or to changes in its internal state in order to maintain homeostasis. This can involve a wide range of physiological processes, such as changes in heart rate, blood pressure, breathing rate, and hormone levels. For example, when a person is exposed to high temperatures, their body may undergo physiological adaptations to help them stay cool. This might include sweating to release heat from the skin, or dilating blood vessels to increase blood flow to the skin and help dissipate heat. Physiological adaptations can also occur in response to changes in an individual's internal state, such as during exercise or when the body is under stress. For example, during exercise, the body may increase its production of oxygen and glucose to meet the increased energy demands of the muscles. Overall, physiological adaptations are a fundamental aspect of how organisms are able to survive and thrive in a changing environment.

Concanavalin A (Con A) is a lectin, a type of protein that binds to specific carbohydrate structures on the surface of cells. It was first isolated from the seeds of the jack bean (Canavalia ensiformis) in the 1960s and has since been widely used in research and medical applications. In the medical field, Con A is often used as a tool to study cell-cell interactions and immune responses. It can bind to a variety of cell types, including T cells, B cells, and macrophages, and has been shown to activate these cells and stimulate their proliferation. Con A is also used as a diagnostic tool to detect and quantify certain types of cells in the blood, such as T cells and natural killer cells. In addition to its use in research and diagnostics, Con A has also been studied for its potential therapeutic applications. For example, it has been shown to have anti-tumor effects in some cancer models by activating the immune system and promoting the destruction of cancer cells. However, more research is needed to fully understand the potential therapeutic benefits of Con A and to determine its safety and efficacy in humans.

Ketocholesterols are a type of cholesterol that are synthesized in the liver from excess dietary fat and are characterized by the presence of a keto group (-COO-) on the side chain. They are also known as cholesteryl esters or cholesteryl esterified fatty acids. Ketocholesterols are an important component of high-density lipoprotein (HDL) particles, which are often referred to as "good" cholesterol because they help transport cholesterol from the bloodstream back to the liver for excretion. However, high levels of circulating ketocholesterols can also contribute to the development of atherosclerosis, a condition in which plaque builds up in the arteries and can lead to heart attack or stroke. In the medical field, the measurement of serum levels of ketocholesterols is often used as a marker of cardiovascular risk and to monitor the effectiveness of cholesterol-lowering therapies.

Dimyristoylphosphatidylcholine (DMPC) is a type of phospholipid, which is a molecule that is essential for the structure and function of cell membranes. It is composed of two fatty acid chains, each containing 16 carbon atoms, and a phosphate group attached to a choline molecule. DMPC is a common component of biological membranes and is often used in scientific research to study the properties of cell membranes and the behavior of membrane proteins. It is also used in the production of liposomes, which are small, spherical structures that can be used to deliver drugs and other molecules into cells.

Stearic acid is a saturated fatty acid that is commonly found in many foods, including vegetable oils, cocoa butter, and beef fat. In the medical field, stearic acid is sometimes used as a pharmaceutical excipient, meaning it is added to medications to help with their stability, solubility, or other properties. It is also used in the production of certain medical devices, such as catheters and implants. In small amounts, stearic acid is generally considered safe for consumption and is not known to cause any harmful side effects. However, in larger amounts, it may have negative effects on heart health and can contribute to the development of certain medical conditions, such as high cholesterol and atherosclerosis.

Cytochalasin B is a fungal metabolite that is used in the medical field as a research tool to study cell biology and cell motility. It is a potent inhibitor of actin polymerization, which is a key process in cell movement and division. Cytochalasin B is often used to study the dynamics of actin filaments and their role in cell migration, endocytosis, and cytokinesis. It is also used to study the effects of actin polymerization on the structure and function of other cellular components, such as microtubules and membrane proteins. In addition, cytochalasin B has been used in the treatment of certain types of cancer, as it can inhibit the growth and spread of cancer cells by disrupting their actin cytoskeleton.

Oleic acid is a monounsaturated fatty acid that is commonly found in plant oils, such as olive oil, sunflower oil, and canola oil. It is a liquid at room temperature and has a distinctive nutty flavor. In the medical field, oleic acid has several potential uses. For example, it has been studied as a potential treatment for high blood pressure, as it may help to relax blood vessels and improve blood flow. It has also been studied as a potential treatment for certain types of cancer, as it may help to inhibit the growth of cancer cells. In addition to its potential therapeutic uses, oleic acid is also used in a variety of other applications in the medical field. For example, it is used as a component of some types of lubricants and as a component of certain types of medical devices. It is also used as a food additive, as it has a long shelf life and a neutral flavor that makes it useful in a variety of food products.

In the medical field, water is a vital substance that is essential for the proper functioning of the human body. It is a clear, odorless, tasteless liquid that makes up the majority of the body's fluids, including blood, lymph, and interstitial fluid. Water plays a crucial role in maintaining the body's temperature, transporting nutrients and oxygen to cells, removing waste products, and lubricating joints. It also helps to regulate blood pressure and prevent dehydration, which can lead to a range of health problems. In medical settings, water is often used as a means of hydration therapy for patients who are dehydrated or have fluid imbalances. It may also be used as a diluent for medications or as a component of intravenous fluids. Overall, water is an essential component of human health and plays a critical role in maintaining the body's normal functions.

In the medical field, the term "cattle" refers to large domesticated animals that are raised for their meat, milk, or other products. Cattle are a common source of food and are also used for labor in agriculture, such as plowing fields or pulling carts. In veterinary medicine, cattle are often referred to as "livestock" and may be treated for a variety of medical conditions, including diseases, injuries, and parasites. Some common medical issues that may affect cattle include respiratory infections, digestive problems, and musculoskeletal disorders. Cattle may also be used in medical research, particularly in the fields of genetics and agriculture. For example, scientists may study the genetics of cattle to develop new breeds with desirable traits, such as increased milk production or resistance to disease.

In biology, membrane fluidity refers to the viscosity of the lipid bilayer of a cell membrane or a synthetic lipid membrane. ... Membrane fluidity is also affected by cholesterol. Cholesterol can make the cell membrane fluid as well as rigid. Membrane ... This is one way they can adjust the fluidity of their membrane in response to their environment. Membrane fluidity is known to ... These membranes are supported by a flat surface, e.g. the bottom of a box. The fluidity of these membranes can be controlled by ...
All of these effects bet on membrane fluidity. It's thought that agaric acid activates the opening of membrane pores due to the ... Its dependence on membrane fluidity". Mitochondrion. 5 (4): 272-81. doi:10.1016/j.mito.2005.05.002. PMID 16050990. García, ... It facilitates the efflux of accumulated Ca2+, disrupts the potential of the membrane and causes mitochondrial lumps. ...
... s have two principal biological functions: as important components of cell membranes that alter membrane fluidity; and ... the latter is a structural component of cell membranes that helps determine the fluidity of cell membranes and is a principal ... and steroids and phospholipids are components of cell membranes. Steroids such as cholesterol decrease membrane fluidity. ... Ergosterol is analogous to the cholesterol found in the cellular membranes of animals (including humans), or the phytosterols ...
Eventually, membrane fluidity and activity of membrane bound enzymes become depleted. It has also been shown to inhibit ... This structure provides the membrane with fluidity. This occurs by transforming lanosterol into 4,4'-dimethyl cholesta-8,14,24- ... Lanosterol is found within the yeast plasma membrane. It is a class of methylsterol. Within a normal yeast cell, lanosterol is ... This process creates zymosterol: a major constituent in the ergosterol biosynthesis pathway for the creation of cell membrane ...
Chattopadhyay, M; Jagannadham, M (2001). "Maintenance of membrane fluidity in antarctic bacteria". Polar Biology. 24 (5): 386- ... Psychrophilic bacteria have also been shown to contain unique lipids and membrane structures which help add stability to the ... membrane of the cells. In general, microorganisms from the Antarctic are used as model organisms for studying methods and tools ...
The way most cells react to the cold is by changing the fluidity of the cellular membrane, but this particular bacterium has ... This is due to various complications of freeze-drying, including the formation of ice crystals, loss of membrane fluidity, and ... "Subcellular membrane fluidity of Lactobacillus delbrueckii subsp. bulgaricus under cold and osmotic stress". Applied ...
Carlini E, Palmerini CA, Cosmi EV, Arienti G (July 1997). "Fusion of sperm with prostasomes: effects on membrane fluidity". ... They possess an unusual lipid composition and a tight and highly ordered structure of their lipid bilayer membrane, resembling ... Minelli A, Moroni M, Martínez E, Mezzasoma I, Ronquist G (November 1998). "Occurrence of prostasome-like membrane vesicles in ... Ronquist G (June 1987). "Effect of modulators on prostasome membrane-bound ATPase in human seminal plasma". European Journal of ...
"Decreased fluidity of red cell membrane lipids in abetalipoproteinemia". The Journal of Clinical Investigation. 60 (1): 115-21 ...
"Decreased fluidity of red cell membrane lipids in abetalipoproteinemia". J. Clin. Invest. 60 (1): 115-21. doi:10.1172/JCI108747 ... Alterations in membrane lipids are seen in abetalipoproteinemia and liver dysfunction. Alteration in membrane structural ... This causes abnormalities of membrane of RBC causing remodeling in spleen and formation of acanthocytes. In ... Acanthocytes arise from either alterations in membrane lipids or structural proteins. ...
For all cells, membrane fluidity is important for many reasons. It enables membrane proteins to diffuse rapidly in the plane of ... A biological membrane, biomembrane or cell membrane is a selectively permeable membrane that separates the interior of a cell ... such as mucous membranes, basement membranes, and serous membranes. The lipid bilayer consists of two layers- an outer leaflet ... If biological membranes were not fluid, it is hard to imagine how cells could live, grow, and reproduce. The fluidity property ...
The phospholipid bilayer gives fluidity and elasticity to the membrane. Small amounts of carbohydrates are also found in the ... The membrane bilayer is not always flat. Local curvature of the membrane can be caused by the asymmetry and non-bilayer ... Cell membrane proteins and glycoproteins do not exist as single elements of the lipid membrane, as first proposed by Singer and ... The fluid mosaic model is the most acceptable model of the plasma membrane. In this definition of the cell membrane, its main ...
Among other things, arachidonic acid helps to maintain hippocampal cell membrane fluidity. It also helps protect the brain from ... "Arachidonic acid preserves hippocampal neuron membrane fluidity in senescent rats". Neurobiology of Aging. 28 (8): 1179-1186. ... Darios, F; Davletov, B (2006). "Omega-3 and omega-6 fatty acids stimulate cell membrane expansion by acting on syntaxin 3". ... of membranes of the body's cells, and is abundant in the brain, muscles, and liver. Skeletal muscle is an especially active ...
These alterations result in changes in membrane fluidity and permeability. These processes along with the accumulation of lipid ... Their amphipathic nature drives the formation of the lipid bilayer structure of membranes. The cell membrane seen under the ... In the cell membrane, the two layers of phospholipids are arranged as follows: the hydrophobic tails point to each other and ... Thus, neural membrane phospholipids are a reservoir for second messengers. They are also involved in apoptosis, modulation of ...
doi:10.1016/0300-9629(78)90273-6. Clarke JR (1977). "Fluidity-induced changes in diffusion through membranes: a predictive ...
Expression of heat shock proteins and regulation of membrane fluidity are just two of many biochemical methods organisms use to ... Los D.A., Murata N. (2004). "Membrane fluidity and its roles in the perception of environmental signals". Biochimica et ... In response to changes in temperature, organisms can change the biochemistry of cell membranes making them more fluid in cold ... temperatures and less fluid in warm temperatures by increasing the number of membrane proteins. In response to certain ...
The main function of cholesterol is controlling the cell membrane fluidity. Steroid - see also steroidogenesis: Steroids are ... Membrane lipid biosynthesis occurs in the endoplasmic reticulum membrane. The phosphatidic acid is also a precursor for ... There are two major classes of membrane lipids: glycerophospholipids and sphingolipids. Although many different membrane lipids ... Other types of lipids found in the body are fatty acids and membrane lipids. Lipid metabolism is often considered as the ...
Lee, R. E.; Damodaran, K.; Yi, S. X.; Lorigan, G. A. (2006). "Rapid Cold-Hardening Increases Membrane Fluidity and Cold ... When temperature drops, the membrane fluidity, RNA and DNA stability, and enzyme activity change. These, in turn, affect ... Cold increases cell membrane permeability and makes the cell shrink, as water is drawn out when ice is formed in the ... To retain the surface area of the cell membrane so it will be able to regain its former volume when temperature rises again, ...
Tang C, Castoldi AF, Costa LG (April 1993). "Effects of the muscarinic agonist oxotremorine on membrane fluidity in rat ...
Also, the cortical NMDA receptor influences membrane fluidity, and is altered in Alzheimer's disease. When the cell is infected ... Each cell membrane can have several kinds of membrane receptors, with varying surface distributions. A single receptor may also ... Cell surface receptors (membrane receptors, transmembrane receptors) are receptors that are embedded in the plasma membrane of ... "Cortical NMDA Receptor Properties and Membrane Fluidity Are Altered in Alzheimer's Disease". Dementia. 7 (4): 210-214. doi: ...
Unsaturated fatty acids and their derived fats increase the fluidity of membranes. Fatty acid desaturase appear in all ... Alberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P (2002). "The Fluidity of a Lipid Bilayer Depends on Its Composition ... This enzyme is involved in chilling tolerance; the phase transition temperature of lipids of cellular membranes being dependent ... Unsaturated fatty acids help maintain structure and function of membranes. Highly unsaturated fatty acids (HUFAs) are ...
... results in the reduced fluidity of their membranes because molecules are squeezed together. Fluidity in cell membranes ... In high pressure environments, bilayer cellular membranes experience a loss of fluidity. Deep-sea cellular membranes favor ... have adapted to this circumstance by increasing the proportion of unsaturated fatty acids in the lipids of the cell membranes. ... phospholipid bilayers with a higher proportion of unsaturated fatty acids, which induce a higher fluidity than their sea-level ...
Majority of the membrane is composed of phospholipids, which exhibit fluidity like oil. The phospholids are not just stationary ... They made a seminal model for the structure of cell membranes, which they named the Fluid Mosaic Model, and published in a 12- ... With S.J. Singer, Nicolson published a paper titled "The fluid mosaic model of the structure of cell membranes" in 1972, which ... According to the Fluid Mosaic Model, in contrast to other models, the cell membrane is composed of a single lipid bilayer which ...
... s influence membrane fluidity and membrane protein trafficking, thereby regulating neurotransmission and receptor ... In 1974, the effects of temperature on membrane behavior had led to the proposal of "clusters of lipids" in membranes and by ... Currently synthetic membranes are studied; however, there are many drawbacks to using these membranes. First, synthetic ... This allows information of the diffusivity of particles in the membrane to be extracted as well as revealing membrane corrals, ...
Müller WE, Koch S, Scheuer K, Rostock A, Bartsch R (January 1997). "Effects of piracetam on membrane fluidity in the aged mouse ... Zhu D, Bungart BL, Yang X, Zhumadilov Z, Lee JC, Askarova S (2015). "Role of membrane biophysics in Alzheimer's-related cell ... Piracetam is thought to increase cell membrane permeability. Piracetam may exert its global effect on brain neurotransmission ... it also increases the permeability of some intermediates of the Krebs cycle through the mitochondrial outer membrane. Piracetam ...
For example, it was used to help establish the existence of a "fluidity gradient" across the membrane bilayer of some tumor ... Schroeder F (November 1978). "Differences in fluidity between bilayer halves of tumour cell plasma membranes". Nature. 276 ( ... with minimal effects on the biophysical properties of the membrane. Molecular interactions with neighboring membrane lipids ... α-Parinaric acid is also used as a chromophore to study interactions between membrane proteins and lipids. Because of the ...
Unsaturated fatty acids increase the fluidity of the membrane and stabilize it under lower temperatures. DesK is the sensor ... DesK is a membrane-associated kinase and DesR is a transcriptional regulator of the des gene. The regulation responds to ... In bacteria with membranes composed mainly of omega-alicyclic fatty acids, the supply of cyclic carboxylic acid-CoA esters is ... Phospholipids form the bulk of the lipid bilayers that make up cell membranes and surrounds the organelles within the cells ( ...
... which increases the fluidity of the membranes. In addition, carotenoids are present in the membrane, which help modulate the ... Compared to longer saturated fatty acids, incorporating this type of fatty acid allows for the lipid cell membrane to have a ... They must also overcome the stiffening of their lipid cell membrane, as this is important for the survival and functionality of ... To accomplish this, psychrophiles adapt lipid membrane structures that have a high content of short, unsaturated fatty acids. ...
"Salt-induced changes in lipid composition and membrane fluidity of halophilic yeast-like melanized fungi". Extremophiles. 8 (1 ... Adaptation to high concentrations of salt are also accompanied by changes in membrane lipid composition, mainly by increasing ...
Membrane fluidity can affect bile flow by regulating the activity of hepatocyte Na+/K+-ATPase, which maintains the inwardly- ... Estrogen may induce a decrease in the fluidity of the hepatic sinusoidal membrane, leading to a decrease in the activity of ... Bile flow was similarly reduced in rats as a result of alterations to basolateral membrane fluidity by ethinylestradiol and ... In rats, cyclosporine A was found to increase canalicular membrane fluidity and consequently reduce bile secretion. ...
Sitosterol regulates membrane fluidity and permeability in a similar manner to cholesterol in mammalian cell membranes. Plant ... Ergosterol is a component of fungal cell membranes, serving the same function in fungi that cholesterol serves in animal cells ... Hartmann, Marie-Andrée (1998). "Plant sterols and the membrane environment". Trends in Plant Science. 3 (5): 170-175. doi: ... Phytosterols are phytosteroids, similar to cholesterol, that serve as structural components of biological membranes of plants. ...
In biology, membrane fluidity refers to the viscosity of the lipid bilayer of a cell membrane or a synthetic lipid membrane. ... Membrane fluidity is also affected by cholesterol. Cholesterol can make the cell membrane fluid as well as rigid. Membrane ... This is one way they can adjust the fluidity of their membrane in response to their environment. Membrane fluidity is known to ... These membranes are supported by a flat surface, e.g. the bottom of a box. The fluidity of these membranes can be controlled by ...
... everything you need for studying or teaching Cell membrane. ... Immediately download the Cell membrane summary, chapter-by- ... Membrane Fluidity The membranes of bacteria function to give the bacterium its shape, allow the passage of molecules from the ... Membrane Cell membranes or plasma membranes surround cells, separating the cytoplasm and organelles on the inside from the ... Membrane Structure Surrounding each cell within the nervous system is a highly complex lipid bilayer called a membrane formed ...
... membrane fluidity maintenance.. Metal(loid) Resistance. The ability of At. ferrivorans strains to tolerate elevated ... OM, Outer Membrane; IM, Inner Membrane; Ec, Extracellular.. FIGURE S3 ,(A) Synteny of chemotaxis and flagellar biosynthesis ... ferrivorans CF27 proteome). 14.0% of them are predicted to be located in the cell membrane. All specific genes were located ... were Replication Recombination and Repair (L), Cell wall/membrane/envelope biogenesis (M), Amino acid transport and ...
Improved cellular membrane fluidity. Key compoenent for neuronal (Brain) membrane integrity .... *7 Weird Things Linked to ... Phosphatidylserine (PS), a phospholipid, and DHA, an omega-3 fatty acid, are major components of cell membranes, particularly ... the membranes of nerve cells. They facilitate the electric signals that are the basis of neuron communication, supporting me ...
Ethanol intercalates into cell membranes, increasing membrane fluidity. Alcohol also affects many signal-transduction proteins ...
Saxena, S., Srivastava, P., and Khanna, V. K. Antioxidant supplementation improves platelet membrane fluidity in idiopathic ... Rapp, L. M., Maple, S. S., and Choi, J. H. Lutein and zeaxanthin concentrations in rod outer segment membranes from perifoveal ...
Thus, the present study investigated this effect on semen motility and sperm membrane properties. Serial semen analyses from ... Total Sperm Count (TSC), Computer-Assisted Sperm Analysis (CASA) indexes, mortality, and functional membrane integrity were ... functional membrane integrity, and decreased mortality. Present results lead us to consider ameliorative effects of a two-month ... influencing the fluidity of lipids, thus in the stability of biological membranes [32], sperm chromatin integrity [33], free ...
Cholesterol, also present, contributes to the fluidity of the membrane. A single phospholipid molecule consists of a polar ... It consists of two phospholipid bilayers: an outer membrane and an inner membrane. The nuclear membrane is continuous with the ... This organelle has an outer membrane and an inner membrane. The inner membrane contains folds, called cristae, which increase ... The Chloroplast Structure: The chloroplast has an outer membrane, an inner membrane, and membrane structures called thylakoids ...
A molecular rotor FLIM probe reveals dynamic coupling between mitochondrial inner membrane fluidity and cellular respiration.. ...
Increase cellular membrane fluidity, decrease peroxidation processes [266]. Decrease LDL and triglycerides, increase HDL [267- ... Metabolic ROS are generated in several cellular systems localized on the plasma membrane, in the cytosol, in peroxisomes, and ... oxidizing membrane lipids, changing the conformation of proteins, damaging nucleic acids) eventually speeding up the process of ... on membranes of mitochondria and endoplasmic reticulum. Functional alterations of these organelles generate excessive ...
... besides modulating membrane fluidity and the structure and function of membrane proteins. The azoles mechanism of action is to ... The presence of 14α-methyl sterols can modify the function and fluidity of the plasma membrane [21]. The additive mutation in ... Cell membrane. Increases membrane permeability. [76]. Scutellaria aicalensis. (flavonoid baicalein). Unknown. Induces apoptosis ... Binds to ergosterol in the membrane resulting in cell death. [80]. Carvacrol (terpene). Cell membrane. Alters cellular ...
Effect of anti-inflammatory drugs on splenocyte membrane fluidity. Analytical Biochemistry, 339(1), 144 - 149.*Google Scholar ...
Water helps to maintain the fluidity of cell membranes, which is crucial for proper signal transmission and connectivity. With ...
This membrane is semi-permable: It regulates what gets into the cell and what goes out of it. The fluidity of cell membranes ... If the fatty membranes surrounding brain cells are relatively fluid, as they are with lots of omega-3s, then messages from ... Because omega-3s and omega-6s compete with each other for space in cell membranes and the attention of enzymes, the ratio ... Cell membranes. Essential fats have an integral role in promoting cell health. ...
... or that the channels respond to temperature-dependent changes in membrane fluidity [38]. ... This residue was located between the second and third trans-membrane domains of the channel, a region known to be important for ... Using a similar approach, Reid and Flonta recorded membrane currents from cultured DRG neurons that they selected based on the ... In addition to calcium, many types of pathological conditions, such as peripheral inflammation, can lead to altered membrane ...
Alterations of human erythrocyte membrane fluidity by oxygen-derived free radicals and calcium. Free Radical Biology and ... Mason, R.P., Mak, I.T., Trumbore, M.W. and Mason, P.E. (1999) Antioxidant properties of Ca antagonists related to membrane ... Zachary, S.B., Jason, D.M., David, J.J. and David, C.M. (2005) Primaquine-induced hemolytic anaemia: role of membrane lipid ... Deuticke, B., Heller, K.B. and Haest, C.W.M. (1987) Progressive oxidative membrane damage in erythrocytes afterpulse treatment ...
... from regulating gene expression to maintaining healthy cell membrane fluidity. To understand the way omega-3 fats help maintain ... Omega-3 fatty acids work much the same way in humans-they keep human cell membranes fluid, flexible, and healthy. This is ...
Membrane fluidity and its roles in the perception of environmental signals. DA Los, N Murata ... Chilling sensitivity in plants and cyanobacteria: the crucial contribution of membrane lipids. I Nishida, N Murata ...
... mutant with reduced major sterols such as sitosterol and stigmasterol in roots presented higher membrane fluidity than the wild ... The cPLA2α C2 domain is known to induce changes in positive membrane curvature, a process which is dependent on cPLA2α membrane ... We found that the association of the cPLA2α C2 domain with membranes is limited to membranes with positive curvature, and ... Depletion of PtdIns(4,5)P(2) from the plasma membrane of HEK293 cells abrogated the membrane deforming activity of EndoA1-BAR ...
... increasing membrane fluidity (through changes in the fatty acid composition), (iii) taking up or producing cryo-protecting ...
... and cholesterol is essential for their function by controlling the fluidity of membranes, thus affecting the freedom of ... Striatal CB1Rs(GABA) function within lipid rafts, which are subdomains of the plasma membranes that contain high concentrations ... through a mechanism mediated by altered cholesterol metabolism and membrane lipid raft function. The effect of BDNF was ... movements of lipid raft-associated proteins, as well as the ability of vesicles to deform and fuse with plasma membranes ( ...
... essential fatty acids used to enhance cell membrane fluidity and function. Although the body can manufacture GLA from dietary ...
... fenugreek dosing was observed to restore synaptosomal membrane fluidity and intrasynaptosomal calcium homeostasis, compared ... 65-68 Normalization of membrane content and distribution of glucose transporter 4 were observed in the skeletal and heart ... and thickening of the basement membrane, compared with controls.84,89,94,95 In 1 study, suppression of diabetic ultrastructural ...
... where it influences membrane fluidity by synthesizing monounsaturated fatty acids, and at the whole-organism level, where it ... In this case, soraphen As inhibition of ACC changed the lipid composition of the endothelial cell membranes and had other ... Researchers find that the lack of a specific membrane-linked receptor protein, PEDF-R, contributes to photoreceptor dysfunction ... Mathematical models of membrane binding. Read about recent papers on these topics. ...
... passive processes might also be altered as membrane fluidity decreases (Frezard and Garnier-Suillerot, 1998; Neuhoff et al., ... control cells and artificial membranes (parallel artificial membrane permeability assay). Whereas for some compounds ( ... A statistically significant underestimation of both Pdif and Pe was observed when CHOneo cells and artificial membranes were ... ABBREVIATIONS: CCK8, cholecystokinin octapeptide sulfated; PAMPA, parallel artificial membrane permeability assay; DMSO, ...
Concerning Membrane Fluidity. Animal studies imply that it may additionally improve or repair brain membrane fluidity, which ...
DHA is one of the most important omega-3 fatty acids in the brain, where it helps regulate membrane fluidity, the formation of ... DHA is one of the most important omega-3 fatty acids in the brain, where it helps regulate membrane fluidity, the formation of ...
Surprisingly, we only observed mild changes to the localization of other regulatory lipids, but membrane fluidity and ... The role of sphingolipids in controlling the endolysosomal membrane trafficking remains unclear. Here, we show that in ... the elongase that adds the final two carbons results in pleiotropic effects that negatively alter membrane fusion at the ... sphingolipids containing C26 VLCFAs act as regulatory lipids in the homotypic vacuolar fusion cascade by assembling membrane ...
  • Plasma Membrane The plasma membrane is a very thin, continuous sheet of phospholipids and proteins that surrounds all living cells and separates them from their external environment. (bookrags.com)
  • Like a prokaryotic cell, a eukaryotic cell has a plasma membrane, cytoplasm, and ribosomes. (coursehero.com)
  • Other than the fact that vacuoles are somewhat larger than vesicles, there is a very subtle distinction between them: the membranes of vesicles can fuse with either the plasma membrane or other membrane systems within the cell. (coursehero.com)
  • MARV assembles and buds from the host cell plasma where MARV matrix protein (mVP40) dimers associate with anionic lipids at the plasma membrane inner leaflet and undergo a dynamic and extensive self-oligomerization into the structural matrix layer. (uci.edu)
  • energetic lipids move around more, arranging and rearranging randomly, making the membrane more fluid. (wikipedia.org)
  • At low temperatures, the lipids are laterally ordered and organized in the membrane, and the lipid chains are mostly in the all-trans configuration and pack well together. (wikipedia.org)
  • While unsaturated lipids may have more rigid individual bonds, membranes made with such lipids are more fluid because the individual lipids cannot pack as tightly as saturated lipids and thus have lower melting points: less thermal energy is required to achieve the same level of fluidity as membranes made with lipids with saturated hydrocarbon chains. (wikipedia.org)
  • Incorporation of particular lipids, such as sphingomyelin, into synthetic lipid membranes is known to stiffen a membrane. (wikipedia.org)
  • Also, a narrow annular lipid shell of membrane lipids in contact with integral membrane proteins have low fluidity compared to bulk lipids in biological membranes, as these lipid molecules stay stuck to surface of the protein macromolecules. (wikipedia.org)
  • The double bond decreases fluidity. (wikipedia.org)
  • Platelet receptors for ADP include the P2Y12 receptor, which sends signals to suppress adenylate cyclase, decreases cyclic adenosine monophosphate (cAMP) levels, and promotes activation of the glycoprotein IIb/IIIa receptor (assembled on the activated platelet surface membrane from glycoproteins IIb and IIIa). (msdmanuals.com)
  • The nucleus stores chromatin (DNA plus proteins) in a gel-like substance called the nucleoplasm.The nucleolus is a condensed region of chromatin where ribosome synthesis occurs.The boundary of the nucleus is called the nuclear envelope.It consists of two phospholipid bilayers: an outer membrane and an inner membrane.The nuclear membrane is continuous with the endoplasmic reticulum.Nuclear pores allow substances to enter and exit the nucleus. (coursehero.com)
  • In 1990 and 1994, mass vaccination was performed by using a vaccine consisting of a serogroup B outer membrane vesicle (B:4:P1.15) and a serogroup C polysaccharide. (cdc.gov)
  • Multilocus sequence typing (MLST) ( 9 ) was performed in combination with outer membrane protein (OMP) gene sequencing ( 10 ) of porA variable regions (VRs) 1 and 2, porB , and fetA VR. (cdc.gov)
  • The biological analogue, 'lipid raft', is hypothesized to exist in cell membranes and perform biological functions. (wikipedia.org)
  • BDNF potently inhibited CB 1 R function in the striatum, through a mechanism mediated by altered cholesterol metabolism and membrane lipid raft function. (jneurosci.org)
  • Membrane fluidity is affected by fatty acids. (wikipedia.org)
  • More specifically, whether the fatty acids are saturated or unsaturated has an effect on membrane fluidity. (wikipedia.org)
  • Thus, the cumulative effect of vitamin E, selenium, zinc, folic acid, and n-3 polyunsaturated fatty acids (PUFA) on sperm motility and membrane properties was investigated in healthy normospermic dogs. (mdpi.com)
  • In fruit flies, an enzyme called DESAT1, a delta-9-desaturase, is a key player in responses to temperature changes at both the cellular level, where it influences membrane fluidity by synthesizing monounsaturated fatty acids, and at the whole-organism level, where it controls temperature-influenced behaviors like mating. (asbmb.org)
  • DHA is one of the most important omega-3 fatty acids in the brain, where it helps regulate membrane fluidity, the formation of synapses, and cytokine production. (buywell.com)
  • Membrane Cell membranes or plasma membranes surround cells, separating the cytoplasm and organelles on the inside from the extracellular fluid on the outside. (bookrags.com)
  • Several cell organelles (mitochondria, en. (bookrags.com)
  • Mitochondria are oval-shaped, double membrane organelles that have their own ribosomes and DNA. (coursehero.com)
  • The melting temperature T m {\displaystyle T_{m}} of a membrane is defined as the temperature across which the membrane transitions from a crystal-like to a fluid-like organization, or vice versa. (wikipedia.org)
  • On the other hand, if people eat too many saturated fats (which are solid at room temperature), without enough omega-3s, then these membranes become more rigid, and stuff can't get through. (irontamer.com)
  • Membrane fluidity and temperature perception. (google.pl)
  • Furthermore, permeability was found to be highly temperature-dependent in Chinese hamster ovary (CHO) control cells and artificial membranes (parallel artificial membrane permeability assay). (aspetjournals.org)
  • Cholesterol can make the cell membrane fluid as well as rigid. (wikipedia.org)
  • The composition of a membrane can also affect its fluidity. (wikipedia.org)
  • The fluidity of cell membranes depend on the fatty acid composition of the diet. (irontamer.com)
  • Membrane Structure Surrounding each cell within the nervous system is a highly complex lipid bilayer called a membrane formed by microscopic phospholipid molecules. (bookrags.com)
  • Both the inner and outer membranes of the nuclear envelope are phospholipid bilayers. (coursehero.com)
  • In biology, membrane fluidity refers to the viscosity of the lipid bilayer of a cell membrane or a synthetic lipid membrane. (wikipedia.org)
  • Everything you need to understand or teach Cell membrane . (bookrags.com)
  • Prokaryotic Membrane Transport The ability of Prokaryotic microorganisms to move compounds into the cell, and to remove waste products of metabolism out of the cell, is crucial for the survival of the. (bookrags.com)
  • Ethanol intercalates into cell membranes, increasing membrane fluidity. (medscape.com)
  • A eukaryotic cell has a true membrane-bound nucleus and has other membranous organelles that allow for compartmentalization of functions. (coursehero.com)
  • Water helps to maintain the fluidity of cell membranes, which is crucial for proper signal transmission and connectivity. (ncenters.com)
  • This membrane is semi-permable: It regulates what gets into the cell and what goes out of it. (irontamer.com)
  • Because omega-3s and omega-6s compete with each other for space in cell membranes and the attention of enzymes, the ratio matters more than the absolute amount consumed of either fat. (irontamer.com)
  • Various mechanisms, including endothelial cell nitric oxide and prostacyclin, promote blood fluidity by preventing platelet aggregation and dilating intact blood vessels. (msdmanuals.com)
  • If the fatty membranes surrounding brain cells are relatively fluid, as they are with lots of omega-3s, then messages from neurochemicals such as serotonin can be transmitted more easily. (irontamer.com)
  • Eukaryotic cells are larger than prokaryotic cells and have a "true" nucleus, membrane-bound organelles, and rod-shaped chromosomes. (coursehero.com)
  • Viscosity of the membrane can affect the rotation and diffusion of proteins and other bio-molecules within the membrane, there-by affecting the functions of these things. (wikipedia.org)
  • Membrane Fluidity The membranes of bacteria function to give the bacterium its shape, allow the passage of molecules from the outside in and from the inside out, and to prevent the internal contents f. (bookrags.com)
  • Membrane fluidity is also affected by cholesterol. (wikipedia.org)
  • At 37 °C, this is the state of the membrane: the presence of cholesterol, though, allows for the membrane stabilization and a more compact organization. (wikipedia.org)
  • Having complex cells in which the genetic material is organized into membrane-bound nuclei. (coursehero.com)
  • Eukaryotic cells have a true nucleus, which means the cell's DNA is surrounded by a membrane. (coursehero.com)
  • Cells in the human body have a fatty membrane (known as the lipid bilayer). (irontamer.com)
  • T m {\displaystyle T>T_{m}} : The membrane is in the liquid-crystal phase, the membrane is less ordered and more fluid. (wikipedia.org)
  • Vesicles and vacuoles are membrane-bound sacs that function in storage and transport. (coursehero.com)
  • 2005). Effect of anti-inflammatory drugs on splenocyte membrane fluidity . (up.pt)
  • The main facotrs affecting membrane fluidity are environmental (ie. (wikipedia.org)
  • These membranes are supported by a flat surface, e.g. the bottom of a box. (wikipedia.org)
  • VWF binds to receptors on the platelet surface membrane (glycoprotein Ib/IX). (msdmanuals.com)
  • The nuclear envelope is a double-membrane structure that constitutes the outermost portion of the nucleus. (coursehero.com)
  • The absence of double bonds increases fluidity. (wikipedia.org)
  • supports that four or more double bonds has a direct correlation to membrane fluidity. (wikipedia.org)