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Medicago truncatulaMedicagoMedicago sativaSinorhizobium melilotiRoot Nodules, PlantSymbiosisPlant RootsMycorrhizaePlant ProteinsNitrogen FixationGene Expression Regulation, PlantSinorhizobiumWorkloadMelilotusRhizobiumLotusGenome, PlantPlants, Genetically ModifiedAphanomycesFabaceaeTrifoliumMolecular Sequence DataDNA, PlantSeedsPlant LeavesSyntenyPhylogenyProanthocyanidinsExpressed Sequence TagsRNA, PlantTrigonellaPlant ShootsSeedlingIndoleacetic AcidsLeghemoglobinChromosomes, PlantGlomeromycotaPlant DiseasesCytokininsPeasAgrobacteriumPlant Growth RegulatorsLigninEthylenesPlant StructuresRhizobiaceaePlant StemsNaphthaleneacetic AcidsColletotrichumAmino Acid SequencePhenotypeMeristemCicerGene Expression ProfilingPlant EpidermisLupinusPulvinusSoybeansGerminationAphidsChromosome MappingEntomophthoraMutationFlowersNitrogenThioredoxin hMultigene FamilyOrobanchePlant TumorsGlutamate Synthase (NADH)Sequence Analysis, DNALens PlantPhloemPhaseolusPlant Vascular BundleBase SequencePterocarpansSequence AlignmentSequence Homology, Amino AcidArachis hypogaeaCotyledon
Medicago truncatula: A plant species of the family FABACEAE used to study GENETICS because it is DIPLOID, self fertile, has a small genome, and short generation time.Medicago: A plant genus of the family FABACEAE. It is distinct from Sweet Clover (MELILOTUS), from Bush Clover (LESPEDEZA), and from Red Clover (TRIFOLIUM).Medicago sativa: A plant species of the family FABACEAE widely cultivated for ANIMAL FEED.Sinorhizobium meliloti: A species of gram-negative, aerobic bacteria that causes formation of root nodules on some, but not all, types of sweet clover, MEDICAGO SATIVA, and fenugreek.Root Nodules, Plant: Knobbed structures formed from and attached to plant roots, especially of LEGUMES, which result from symbiotic infection by nitrogen fixing bacteria such as RHIZOBIUM or FRANKIA. Root nodules are structures related to MYCORRHIZAE formed by symbiotic associations with fungi.Symbiosis: The relationship between two different species of organisms that are interdependent; each gains benefits from the other or a relationship between different species where both of the organisms in question benefit from the presence of the other.Plant Roots: The usually underground portions of a plant that serve as support, store food, and through which water and mineral nutrients enter the plant. (From American Heritage Dictionary, 1982; Concise Dictionary of Biology, 1990)Mycorrhizae: Symbiotic combination (dual organism) of the MYCELIUM of FUNGI with the roots of plants (PLANT ROOTS). The roots of almost all higher plants exhibit this mutually beneficial relationship, whereby the fungus supplies water and mineral salts to the plant, and the plant supplies CARBOHYDRATES to the fungus. There are two major types of mycorrhizae: ectomycorrhizae and endomycorrhizae.Plant Proteins: Proteins found in plants (flowers, herbs, shrubs, trees, etc.). The concept does not include proteins found in vegetables for which VEGETABLE PROTEINS is available.Nitrogen Fixation: The process in certain BACTERIA; FUNGI; and CYANOBACTERIA converting free atmospheric NITROGEN to biologically usable forms of nitrogen, such as AMMONIA; NITRATES; and amino compounds.Gene Expression Regulation, Plant: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in plants.Sinorhizobium: A genus of gram-negative, aerobic, nonsporeforming rods which usually contain granules of poly-beta-hydroxybutyrate. (From Bergey's Manual of Determinative Bacteriology, 9th ed)Workload: The total amount of work to be performed by an individual, a department, or other group of workers in a period of time.Melilotus: A plant genus of the family FABACEAE.Rhizobium: A genus of gram-negative, aerobic, rod-shaped bacteria that activate PLANT ROOT NODULATION in leguminous plants. Members of this genus are nitrogen-fixing and common soil inhabitants.Lotus: A plant genus of the family FABACEAE. This genus was formerly known as Tetragonolobus. The common name of lotus is also used for NYMPHAEA and NELUMBO.Genome, Plant: The genetic complement of a plant (PLANTS) as represented in its DNA.Plants, Genetically Modified: PLANTS, or their progeny, whose GENOME has been altered by GENETIC ENGINEERING.Aphanomyces: A genus of OOMYCETES in the family Saprolegniaceae. It causes root rot in plants and is also a pathogen of FISHES.Fabaceae: The large family of plants characterized by pods. Some are edible and some cause LATHYRISM or FAVISM and other forms of poisoning. Other species yield useful materials like gums from ACACIA and various LECTINS like PHYTOHEMAGGLUTININS from PHASEOLUS. Many of them harbor NITROGEN FIXATION bacteria on their roots. Many but not all species of "beans" belong to this family.Trifolium: A plant genus of the family FABACEAE.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.DNA, Plant: Deoxyribonucleic acid that makes up the genetic material of plants.Seeds: The encapsulated embryos of flowering plants. They are used as is or for animal feed because of the high content of concentrated nutrients like starches, proteins, and fats. Rapeseed, cottonseed, and sunflower seed are also produced for the oils (fats) they yield.Plant Leaves: Expanded structures, usually green, of vascular plants, characteristically consisting of a bladelike expansion attached to a stem, and functioning as the principal organ of photosynthesis and transpiration. (American Heritage Dictionary, 2d ed)Synteny: The presence of two or more genetic loci on the same chromosome. Extensions of this original definition refer to the similarity in content and organization between chromosomes, of different species for example.Phylogeny: The relationships of groups of organisms as reflected by their genetic makeup.Proanthocyanidins: Dimers and oligomers of flavan-3-ol units (CATECHIN analogs) linked mainly through C4 to C8 bonds to leucoanthocyanidins. They are structurally similar to ANTHOCYANINS but are the result of a different fork in biosynthetic pathways.Expressed Sequence Tags: Partial cDNA (DNA, COMPLEMENTARY) sequences that are unique to the cDNAs from which they were derived.RNA, Plant: Ribonucleic acid in plants having regulatory and catalytic roles as well as involvement in protein synthesis.Trigonella: A plant genus of the family FABACEAE.Plant Shoots: New immature growth of a plant including stem, leaves, tips of branches, and SEEDLINGS.Seedling: Very young plant after GERMINATION of SEEDS.Indoleacetic Acids: Acetic acid derivatives of the heterocyclic compound indole. (Merck Index, 11th ed)Leghemoglobin: A hemoglobin-like oxygen-binding hemeprotein present in the nitrogen-fixing root nodules of leguminous plants. The red pigment has a molecular weight approximately 1/4 that of hemoglobin and has been suggested to act as an oxido-reduction catalyst in symbiotic nitrogen fixation.Chromosomes, Plant: Complex nucleoprotein structures which contain the genomic DNA and are part of the CELL NUCLEUS of PLANTS.Glomeromycota: A phylum of fungi that are mutualistic symbionts and form ARBUSCULAR MYCORRHIZAE with PLANT ROOTS.Plant Diseases: Diseases of plants.Cytokinins: Plant hormones that promote the separation of daughter cells after mitotic division of a parent cell. Frequently they are purine derivatives.Peas: A variable annual leguminous vine (Pisum sativum) that is cultivated for its rounded smooth or wrinkled edible protein-rich seeds, the seed of the pea, and the immature pods with their included seeds. (From Webster's New Collegiate Dictionary, 1973)Agrobacterium: A genus of gram negative, aerobic, rod-shaped bacteria found in soil, plants, and marine mud.Plant Growth Regulators: Any of the hormones produced naturally in plants and active in controlling growth and other functions. There are three primary classes: auxins, cytokinins, and gibberellins.Lignin: The most abundant natural aromatic organic polymer found in all vascular plants. Lignin together with cellulose and hemicellulose are the major cell wall components of the fibers of all wood and grass species. Lignin is composed of coniferyl, p-coumaryl, and sinapyl alcohols in varying ratios in different plant species. (From Merck Index, 11th ed)Ethylenes: Derivatives of ethylene, a simple organic gas of biological origin with many industrial and biological use.Plant Structures: The parts of plants, including SEEDS.Rhizobiaceae: A family of gram-negative bacteria which are saprophytes, symbionts, or plant pathogens.Plant Stems: Parts of plants that usually grow vertically upwards towards the light and support the leaves, buds, and reproductive structures. (From Concise Dictionary of Biology, 1990)Naphthaleneacetic Acids: Naphthalene derivatives containing the -CH2CCO2H radical at the 1-position, the 2-position, or both. Compounds are used as plant growth regulators to delay sprouting, exert weed control, thin fruit, etc.Colletotrichum: A genus of mitosporic Phyllachoraceae fungi which contains at least 40 species of plant parasites. They have teleomorphs in the genus Glomerella (see PHYLLACHORALES).Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Phenotype: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.Meristem: A group of plant cells that are capable of dividing infinitely and whose main function is the production of new growth at the growing tip of a root or stem. (From Concise Dictionary of Biology, 1990)Cicer: A plant genus of the family FABACEAE known for the edible beans.Gene Expression Profiling: The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.Plant Epidermis: A thin layer of cells forming the outer integument of seed plants and ferns. (Random House Unabridged Dictionary, 2d ed)Lupinus: A plant genus of the family FABACEAE that is a source of SPARTEINE, lupanine and other lupin alkaloids.Pulvinus: A group of cells at the base of a leaf in certain plants that, by rapidly losing water, brings about changes in the position of the leaves. (Concise Dictionary of Biology, 1990)Soybeans: An annual legume. The SEEDS of this plant are edible and used to produce a variety of SOY FOODS.Germination: The initial stages of the growth of SEEDS into a SEEDLINGS. The embryonic shoot (plumule) and embryonic PLANT ROOTS (radicle) emerge and grow upwards and downwards respectively. Food reserves for germination come from endosperm tissue within the seed and/or from the seed leaves (COTYLEDON). (Concise Dictionary of Biology, 1990)Aphids: A family (Aphididae) of small insects, in the suborder Sternorrhyncha, that suck the juices of plants. Important genera include Schizaphis and Myzus. The latter is known to carry more than 100 virus diseases between plants.Chromosome Mapping: Any method used for determining the location of and relative distances between genes on a chromosome.Entomophthora: A genus of fungi in the family Entomophthoraceae, order Entomorphthorales. They are primarily parasites of insects and spiders, but have been found to cause mycotic infections of the nose in man and horses.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Flowers: The reproductive organs of plants.Nitrogen: An element with the atomic symbol N, atomic number 7, and atomic weight [14.00643; 14.00728]. Nitrogen exists as a diatomic gas and makes up about 78% of the earth's atmosphere by volume. It is a constituent of proteins and nucleic acids and found in all living cells.Thioredoxin h: A thioredoxin subtype that is ubiquitously found in the plant kingdom. It reduces a variety of seed storage proteins and may play a role in the germination process of seeds.Multigene Family: A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)Orobanche: A plant genus of the family OROBANCHACEAE. Lacking chlorophyll, they are nonphotosynthetic parasitic plants. The common name is similar to Broom or Scotch Broom (CYTISUS) or Butcher's Broom (RUSCUS) or Desert Broom (BACCHARIS) or Spanish Broom (SPARTIUM) or Brome (BROMUS).Plant Tumors: A localized proliferation of plant tissue forming a swelling or outgrowth, commonly with a characteristic shape and unlike any organ of the normal plant. Plant tumors or galls usually form in response to the action of a pathogen or a pest. (Holliday, P., A Dictionary of Plant Pathology, 1989, p330)Glutamate Synthase (NADH): A FLAVOPROTEIN enzyme for AMMONIA assimilation in BACTERIA, microorganisms and PLANTS. It catalyzes the oxidation of 2 molecules of L-GLUTAMATE to generate L-GLUTAMINE and 2-oxoglutarate in the presence of NAD+.Sequence Analysis, DNA: A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.Lens Plant: A plant genus of the FABACEAE family known for the seeds used as food.Phloem: Plant tissue that carries nutrients, especially sucrose, by turgor pressure. Movement is bidirectional, in contrast to XYLEM where it is only upward. Phloem originates and grows outwards from meristematic cells (MERISTEM) in the vascular cambium. P-proteins, a type of LECTINS, are characteristically found in phloem.Phaseolus: A plant genus in the family FABACEAE which is the source of edible beans and the lectin PHYTOHEMAGGLUTININS.Plant Vascular Bundle: A strand of primary conductive plant tissue consisting essentially of XYLEM, PHLOEM, and CAMBIUM.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Pterocarpans: A group of compounds which can be described as benzo-pyrano-furano-benzenes which can be formed from ISOFLAVONES by internal coupling of the B ring to the 4-ketone position. Members include medicarpin, phaseolin, and pisatin which are found in FABACEAE.Sequence Alignment: The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.Sequence Homology, Amino Acid: The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.Arachis hypogaea: A plant species of the family FABACEAE that yields edible seeds, the familiar peanuts, which contain protein, oil and lectins.Cotyledon: A part of the embryo in a seed plant. The number of cotyledons is an important feature in classifying plants. In seeds without an endosperm, they store food which is used in germination. In some plants, they emerge above the soil surface and become the first photosynthetic leaves. (From Concise Dictionary of Biology, 1990)

On the species of origin: diagnosing the source of symbiotic transcripts. (1/168)

BACKGROUND: Most organisms have developed ways to recognize and interact with other species. Symbiotic interactions range from pathogenic to mutualistic. Some molecular mechanisms of interspecific interaction are well understood, but many remain to be discovered. Expressed sequence tags (ESTs) from cultures of interacting symbionts can help identify transcripts that regulate symbiosis, but present a unique challenge for functional analysis. Given a sequence expressed in an interaction between two symbionts, the challenge is to determine from which organism the transcript originated. For high-throughput sequencing from interaction cultures, a reliable computational approach is needed. Previous investigations into GC nucleotide content and comparative similarity searching provide provisional solutions, but a comparative lexical analysis, which uses a likelihood-ratio test of hexamer counts, is more powerful. RESULTS: Validation with genes whose origin and function are known yielded 94% accuracy. Microbial (non-plant) transcripts comprised 75% of a Phytophthora sojae-infected soybean (Glycine max cv Harasoy) library, contrasted with 15% or less in root tissue libraries of Medicago truncatula from axenic, Phytophthora medicaginis-infected, mycorrhizal, and rhizobacterial treatments. Mycorrhizal libraries contained about 23% microbial transcripts; an axenic plant library contained a similar proportion of putative microbial transcripts. CONCLUSIONS: Comparative lexical analysis offers numerous advantages over alternative approaches. Many of the transcripts isolated from mixed cultures were of unknown function, suggesting specificity to symbiotic metabolism and therefore candidates likely to be interesting for further functional investigation. Future investigations will determine whether the abundance of non-plant transcripts in a pure plant library indicates procedural artifacts, horizontally transferred genes, or other phenomena.  (+info)

A phosphate transporter gene from the extra-radical mycelium of an arbuscular mycorrhizal fungus Glomus intraradices is regulated in response to phosphate in the environment. (2/168)

The majority of vascular flowering plants are able to form symbiotic associations with arbuscular mycorrhizal fungi. These symbioses, termed arbuscular mycorrhizas, are mutually beneficial, and the fungus delivers phosphate to the plant while receiving carbon. In these symbioses, phosphate uptake by the arbuscular mycorrhizal fungus is the first step in the process of phosphate transport to the plant. Previously, we cloned a phosphate transporter gene involved in this process. Here, we analyze the expression and regulation of a phosphate transporter gene (GiPT) in the extra-radical mycelium of the arbuscular mycorrhizal fungus Glomus intraradices during mycorrhizal association with carrot or Medicago truncatula roots. These analyses reveal that GiPT expression is regulated in response to phosphate concentrations in the environment surrounding the extra-radical hyphae and modulated by the overall phosphate status of the mycorrhiza. Phosphate concentrations, typical of those found in the soil solution, result in expression of GiPT. These data imply that G. intraradices can perceive phosphate levels in the external environment but also suggest the presence of an internal phosphate sensing mechanism.  (+info)

Overlapping plant signal transduction pathways induced by a parasitic nematode and a rhizobial endosymbiont. (3/168)

Root-knot nematodes and rhizobia establish interactions with roots characterized by the de novo induction of host structures, termed giant cells and nodules, respectively. Two transcription regulators, PHAN and KNOX, required for the establishment of meristems were previously shown to be expressed in tomato giant cells. We isolated the orthologues of PHAN and KNOX (Mt-phan and Mt-knox-1) from the model legume Medicago truncatula, and established the spatial distribution of their expression in situ. We confirmed that Mt-phan and Mt-knox-1 are expressed in lateral root initials and in nematode-induced giant cells and showed that they are expressed in nodules induced by Sinorhizobium meliloti. Expression of both genes becomes spatially restricted as the nodules develop. We further examined nematode feeding sites for the expression of two genes involved in nodule formation, ccs52 (encodes a mitotic inhibitor) and ENOD40 (encodes an early, nodulation mitogen), and found transcripts of both genes to be present in and around giant cells induced in Medicago. Collectively, these results reveal common elements of host responses to mutualistic and parasitic plant endosymbionts and imply that overlapping regulatory pathways lead to giant cells and nodules. We discuss these pathways in the context of phytohormones and parallels between beneficial symbiosis and disease.  (+info)

Salmonella Typhimurium infections transmitted by chlorine-pretreated clover sprout seeds. (4/168)

Raw seed sprouts have caused numerous outbreaks of enteric infections. Presoaking seeds in a 20,000 mg/liter (ppm) calcium hypochlorite solution before sprouting is recommended to reduce bacterial contamination and infection risk. In 1999, the authors investigated an outbreak of Salmonella serotype Typhimurium infections in Colorado. In a case-control study, they matched 20 cases with 58 controls by age, sex, and telephone prefix; 10 (52%) of 19 cases and no controls recalled eating raw alfalfa-style sprouts in the 5 days before the patient's illness (p < 0.00001). Traceback implicated clover sprouts grown from seeds shared by two sprouters. The time period and region over which these sprouts were sold matched the occurrences of 112 culture-confirmed illnesses. Only one of the sprouters presoaked seeds as recommended, and fewer infections were attributable to this sprouter (0.29 vs. 1.13 culture-confirmed infections/50-pound (110.1-kg) bag of seed). After recall of the implicated sprouts and seed, S. Typhimurium illnesses declined. Contaminated raw clover sprouts can cause outbreaks of enteric illness. Presoaking contaminated seeds in a 20,000 mg/liter calcium hypochlorite solution reduces, but does not eliminate, the risk of infection. Until safer production methods are developed, persons eating raw sprouts continue to risk developing potentially serious gastrointestinal illness.  (+info)

Medicago truncatula plants overexpressing the early nodulin gene enod40 exhibit accelerated mycorrhizal colonization and enhanced formation of arbuscules. (5/168)

The mutualistic symbiosis between flowering plants and arbuscular mycorrhizal fungi is extremely abundant in terrestrial ecosystems. In this symbiosis, obligately biotrophic fungi colonize the root of the host plants, which can benefit from these fungi by enhanced access to mineral nutrients in the soil, especially phosphorus. One of the main goals of research on this symbiosis is to find plant genes that control fungal development in the host plant. In this work, we show that mycorrhizal colonization is regulated by enod40, an early nodulin gene known to be involved in the nodule symbiosis of legumes with nitrogen-fixing bacteria. Medicago truncatula plants overexpressing enod40 exhibited stimulated mycorrhizal colonization in comparison with control plants. Overexpression of enod40 promoted fungal growth in the root cortex and increased the frequency of arbuscule formation. Transgenic lines with suppressed levels of enod40 transcripts, likely via a cosuppression phenomenon induced by the transgene, exhibited reduced mycorrhizal colonization. Hence, enod40 might be a plant regulatory gene involved in the control of the mycorrhizal symbiosis.  (+info)

Immunodominant membrane proteins from two phytoplasmas in the aster yellows clade (chlorante aster yellows and clover phyllody) are highly divergent in the major hydrophilic region. (6/168)

The mechanisms by which phytoplasmas interact with their hosts are not understood. Mollicute membrane proteins may play a role in such interactions and therefore the amp genes encoding immunodominant proteins from two phytoplasmas, aster yellows and clover phyllody, which fall within the largest taxonomic subclade of the phytoplasmas, have been cloned and characterized. The putative translation products, antigenic membrane proteins (Amps), of these genes have properties which are typical for bacterial membrane proteins, and which suggest that each has a single large extracellular hydrophilic domain held by a transmembrane region near the C-terminus, with only a short C-terminal intracellular sequence. Both of the Amps characterized here have bacterial leader sequences which are cleaved during maturation. Whilst the signal peptide and transmembrane regions of the two proteins are very similar, the major hydrophilic domains are highly divergent in both size and sequence. The Amps from the two phytoplasmas are also different in structure and sequence from the immunodominant membrane proteins of three other phytoplasmas whose genes have been cloned previously.  (+info)

The molecular genetic linkage map of the model legume Medicago truncatula: an essential tool for comparative legume genomics and the isolation of agronomically important genes. (7/168)

BACKGROUND: The legume Medicago truncatula has emerged as a model plant for the molecular and genetic dissection of various plant processes involved in rhizobial, mycorrhizal and pathogenic plant-microbe interactions. Aiming to develop essential tools for such genetic approaches, we have established the first genetic map of this species. Two parental homozygous lines were selected from the cultivar Jemalong and from the Algerian natural population (DZA315) on the basis of their molecular and phenotypic polymorphism. RESULTS: An F2 segregating population of 124 individuals between these two lines was obtained using an efficient manual crossing technique established for M. truncatula and was used to construct a genetic map. This map spans 1225 cM (average 470 kb/cM) and comprises 289 markers including RAPD, AFLP, known genes and isoenzymes arranged in 8 linkage groups (2n = 16). Markers are uniformly distributed throughout the map and segregation distortion is limited to only 3 linkage groups. By mapping a number of common markers, the eight linkage groups are shown to be homologous to those of diploid alfalfa (M. sativa), implying a good level of macrosynteny between the two genomes. Using this M. truncatula map and the derived F3 populations, we were able to map the Mtsym6 symbiotic gene on linkage group 8 and the SPC gene, responsible for the direction of pod coiling, on linkage group 7. CONCLUSIONS: These results demonstrate that Medicago truncatula is amenable to diploid genetic analysis and they open the way to map-based cloning of symbiotic or other agronomically-important genes using this model plant.  (+info)

Pharmacological analysis of nod factor-induced calcium spiking in Medicago truncatula. Evidence for the requirement of type IIA calcium pumps and phosphoinositide signaling. (8/168)

Bacterial Nod factors trigger a number of cellular responses in root hairs of compatible legume hosts, which include periodic, transient increases in cytosolic calcium levels, termed calcium spiking. We screened 13 pharmaceutical modulators of eukaryotic signal transduction for effects on Nod factor-induced calcium spiking. The purpose of this screening was 2-fold: to implicate enzymes required for Nod factor-induced calcium spiking in Medicago sp., and to identify inhibitors of calcium spiking suitable for correlating calcium spiking to other Nod factor responses to begin to understand the function of calcium spiking in Nod factor signal transduction. 2-Aminoethoxydiphenylborate, caffeine, cyclopiazonic acid (CPA), 2,5-di-(t-butyl)-1,4-hydroquinone, and U-73122 inhibit Nod factor-induced calcium spiking. CPA and U-73122 are inhibitors of plant type IIA calcium pumps and phospholipase C, respectively, and implicate the requirement for these enzymes in Nod factor-induced calcium spiking. CPA and U-73122 inhibit Nod factor-induced calcium spiking robustly at concentrations with no apparent toxicity to root hairs, making CPA and U-73122 suitable for testing whether calcium spiking is causal to subsequent Nod factor responses.  (+info)

2013 September2013 September
Scientists once gravitated toward thinking that non-legumes, which are not infected by rhizobia, just werent capable of receiving the NOD factor signal. But, a less popular theory guessed that plants like corn do receive the NOD factor signal but interpret it differently or have a problem with the mechanistic pathway.. Stacey said figuring out which is happening is like fixing a motion-detecting light.. "If you walk into a room and the light doesnt turn on, either the motion detector is broken or theres a breakdown of the electrical circuit between the detector and the light bulb," Stacey said. "The analogy in a corn plant would be that it either doesnt recognize the signal or recognizes the signal but lacks the ability to couple it with downstream developmental effects.". Staceys lab set out to determine which was true.. Corn, soybean, tomato and Arabidopsis were treated with bacterial flagellin, a protein known to cause a strong immune response, and also received doses of the NOD factor. ...
Nod factor-induced phospholipid signalling in legumesNod factor-induced phospholipid signalling in legumes
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Salt stress alters DNA methylation levels in alfalfa (Medicago spp) - Fingerprint - Sultan Qaboos University: OMAN House...Salt stress alters DNA methylation levels in alfalfa (Medicago spp) - Fingerprint - Sultan Qaboos University: OMAN House...
Fingerprint Dive into the research topics of Salt stress alters DNA methylation levels in alfalfa (Medicago spp). Together they form a unique fingerprint. ...
Medicago truncatula Genome Project :: Mutant Information :: ReferencesMedicago truncatula Genome Project :: Mutant Information :: References
The NFP locus of Medicago truncatula controls an early step of Nod factor signal transduction upstream of a rapid calcium flux and root hair deformation. Plant Journal. 2003; 34(4):495-506.[more]. ...
Frontiers | Ultrastructural and Cytological Studies on Mycosphaerella pinodes Infection of the Model Legume Medicago truncatula...Frontiers | Ultrastructural and Cytological Studies on Mycosphaerella pinodes Infection of the Model Legume Medicago truncatula...
Ascochyta (Mycosphaerella) blight on cultivated peas is primarily caused by infection through asexual spores (pycnospores) of Mycosphaerella pinodes (Berk. et Blox.) Vestergren [recently renamed Peyronellaea pinodes (Berk. & A. Bloxam) Aveskamp, Gruyter & Verkley]. Using a recently developed model pathosystem involving Medicago truncatula and M. pinodes strain OMP-1, we examined the histology and ultrastructure of early infection events and fungal development including penetration by appressoria, vegetative growth of infection hyphae, and host responses. On the susceptible ecotype R108-1, pycnospores germinated and grew over the surface of the epidermis, then formed an appressoria and penetrated the cuticle. Beneath the cuticle, the infection peg expanded into a hyphae that grew within the outer wall of the epidermis. Subsequently, the hyphae penetrated down within mesophyll cells and proliferated vigorously, eventually, forming asexual fruiting bodies (pycnidia). In contrast, successful penetration and
Botany & Plant Biology 2007 - Abstract SearchBotany & Plant Biology 2007 - Abstract Search
Plant-Symbiont Interactions. Venkateshwaran, Muthusubramanian [1], Riely, Brendan K. [2], Peiter, Edgar [3], Sun, Jongho [4], Heckmann, Anne B. [4], Lougnon, Geraldine [5], Edwards, Anne [4], Otegui, Marisa [6], Freshour, Glenn [7], Hahn, Michael G. [7], Sanders, Dale [3], Oldroyd, Giles E. D. [8], Downie, Allan J. [4], Cook, Douglas R. [9], Ane, Jean-Michel [10]. Medicago truncatula DMI1 localizes to the nuclear envelope and regulates Nod factor-induced calcium spiking.. In addition to establishing symbiotic relationships with arbuscular mycorrhizal fungi, legumes also enter into a nitrogen-fixing symbiosis with rhizobial bacteria that result in the formation of root nodules. Several genes required for the development of these symbioses have been cloned in model legumes. Among them, the M. truncatula DMI1 protein shares strong homologies with prokaryotic ion channels such as MthK. Two DMI1 homologs in L. japonicus, named CASTOR and POLLUX, have been localized in plastids. However our studies ...
Establishment of a root proteome reference map for the model legume Medicago truncatula using the expressed sequence tag...Establishment of a root proteome reference map for the model legume Medicago truncatula using the expressed sequence tag...
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Medicago truncatula ENOD11 protein Summary Report | CureHunterMedicago truncatula ENOD11 protein Summary Report | CureHunter
Medicago truncatula ENOD11 protein: from Medicago truncatula; a repetitive proline-rich protein encoded by an early nodulin gene expressed during mycorrization in Arbuscule-containing cells; amino acid sequence in first source
Frontiers | Identification and Network-Enabled Characterization of Auxin Response Factor Genes in Medicago truncatula | Plant...Frontiers | Identification and Network-Enabled Characterization of Auxin Response Factor Genes in Medicago truncatula | Plant...
The Auxin Response Factor (ARF) family of transcription factors is an important regulator of environmental response and symbiotic nodulation in the legume Medicago truncatula. While previous studies have identified members of this family, a recent spurt in gene expression data coupled with genome update and reannotation calls for a reassessment of the prevalence of ARF genes and their interaction networks in M. truncatula. We performed a comprehensive analysis of the M. truncatula genome and transcriptome that entailed search for novel ARF genes and the co-expression networks. Our investigation revealed 8 novel M. truncatula ARF (MtARF) genes, of the total 22 identified, and uncovered novel gene co-expression networks as well. Furthermore, the topological clustering and single enrichment analysis of several network models revealed the roles of individual members of the MtARF family in nitrogen regulation, nodule initiation, and post-embryonic development through a specialized protein packaging and
Development of a software infrastructure to mine GeneChip expression data and to combine datasets from different Medicago...Development of a software infrastructure to mine GeneChip expression data and to combine datasets from different Medicago...
Medicago truncatula is a model plant for studying legume biology. The ability to interact with beneficial microbial organisms leading to the formation of nitrogen fixing root nodules and to phosphate-acquiring arbuscular mycorriza (AM) is one of the main distinctive features of this family of plants. The two different symbioses of Medicago truncatula are investigated by various international research projects. Oligonucleotide microarrays are a robust technique to examine the expression of thousands of genes in parallel. Affymetrix GeneChips®, more recently designed gene-specific chips, make it easier for the researcher to compare and evaluate gene expression and thus will most certainly lead to more accurate results. Not surprisingly, Medicago GeneChips® are moving into the focus of gene expression analysis research in this model plant. Software applications for the analysis of GeneChips® are mostly commercial, or implemented as command-line tools without a user interface. Furthermore, a ...
Sinorhizobium medicae (strain WSM419) (Ensifer medicae)Sinorhizobium medicae (strain WSM419) (Ensifer medicae)
p>An evidence describes the source of an annotation, e.g. an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc.,/p> ,p>,a href="/manual/evidences">More…,/a>,/p> ...
Production and Characterization of Diverse Developmental Mutants of Medicago truncatula | Plant PhysiologyProduction and Characterization of Diverse Developmental Mutants of Medicago truncatula | Plant Physiology
The molecular dissection of plant growth and development in model plants such as Arabidopsis has largely relied on genetic approaches involving the isolation and subsequent characterization of mutants affected in specific biological processes. The utility of this approach now encompasses virtually every facet of plant biology, beginning from plant embryogenesis to flowering and senescence, and plant-pathogen interactions.. Despite the general validity of Arabidopsis as a model plant species, several biological processes do not occur in Arabidopsis and are better studied in other species. Examples of such species-processes combinations include tomato for climacteric fruit ripening, maize for regulation of seed storage protein biosynthesis, and legumes for study of plant symbiotic interactions with nitrogen-fixing bacteria (collectively termed rhizobia) and fungal symbionts (collectively termed mycorrhizae).. In contrast to the large impact plant mutants have had on a molecular dissection of plant ...
A genetic screen for plant mutants with altered nodulation phenotypes in response to rhizobial glycan mutants - Forskning -...A genetic screen for plant mutants with altered nodulation phenotypes in response to rhizobial glycan mutants - Forskning -...
Nodule primordia induced by rhizobial glycan mutants often remain uninfected. To identify processes involved in infection and organogenesis we used forward genetics to identify plant genes involved in perception and responses to bacterial glycans. To dissect the mechanisms underlying the negative plant responses to the Mesorhizobium loti R7AexoU and ML001cep mutants, a screen for genetic suppressors of the nodulation phenotypes was performed on a chemically mutagenized Lotus population. Two mutant lines formed infected nitrogen-fixing pink nodules, while five mutant lines developed uninfected large white nodules, presumably altered in processes controlling organogenesis. Genetic mapping identified a mutation in the cytokinin receptor Lhk1 resulting in an alanine to valine substitution adjacent to a coiled-coil motif in the juxta-membrane region of LHK1. This results in a spontaneous nodulation phenotype and increased ethylene production. The allele was renamed snf5, and segregation studies of ...
All Publications | Max Planck Institute of Molecular Plant PhysiologyAll Publications | Max Planck Institute of Molecular Plant Physiology
Kuester, H.; Hohnjec, N.; Krajinski, F.; El Yahyaoui, F.; Manthey, K.; Gouzy, J.; Dondrup, M.; Meyer, F.; Kalinowski, J.; Brechenmacher, L. et al.; van Tuinen, D.; Gianinazzi-Pearson, V.; Puehler, A.; Gamas, P.; Becker, A.: Construction and validation of cDNA-based Mt6k-RIT macro- and microarrays to explore root endosymbioses in the model legume Medicago truncatula. Journal of Biotechnology 108 (2), pp. 95 - 113 (2004 ...
Medicago lupulina - Species Page - ISB: Atlas of Florida PlantsMedicago lupulina - Species Page - ISB: Atlas of Florida Plants
The Atlas of Florida Plants provides a source of information for the distribution of plants within the state and taxonomic information. The website also provides access to a database and images of herbarium specimens found at the University of South Florida and other herbaria.
Medicago Reports Positive Phase I Results for its Avian Flu Pandemic Vaccine | Pressemitteilung MedicagoMedicago Reports Positive Phase I Results for its Avian Flu Pandemic Vaccine | Pressemitteilung Medicago
Quebec City (ots/PRNewswire) - Medicago Inc. a biotechnology company focused on developing highly effective and affordable vaccines based on proprietary manufacturing...
Comparative Genetic Mapping and Discovery of Linkage Disequilibrium Across Linkage Groups in White Clover (Trifolium repens L.)...Comparative Genetic Mapping and Discovery of Linkage Disequilibrium Across Linkage Groups in White Clover (Trifolium repens L.)...
The original aim of this study was to develop EST-SSR markers and linkage maps for molecular genetics analysis in white clover. We achieved this by generating 1973 WCS markers and an integrated map with 1743 loci. WGS markers were designed based on the accumulated 7982 non-redundant white clover EST sequences. Although the number of accumulated EST sequences was limited, the proportion of KOG functional categories represented by the accumulated EST sequences was comparable to the proportion predicted in the genomes of Arabidopsis, L. japonicas, and rice. In addition, the distribution of the identified SSR motifs in the accumulated white clover EST sequences was basically similar to the distribution found in the genomes of other legume species, such as L. japonicas (Sato et al. 2008). Therefore, no specific bias should be observed in the accumulated white clover EST sequences.. In parallel, we discovered the existence of LD across linkage groups on the T17-349-specific map. Although the ...
Leaf anatomy of the South African Danthonieae (Poaceae). VII. Merxmuellera decora, M. lupulina and M. rufa | Ellis |...Leaf anatomy of the South African Danthonieae (Poaceae). VII. Merxmuellera decora, M. lupulina and M. rufa | Ellis |...
Bothalia: African Biodiveristy & Conservation is published by AOSIS for the South African National Biodiversity Institute (SANBI) and aims to disseminate knowledge, information and innovative approaches that promote and enhanve the wise use and management of biodiversity in order to sustain the systems and species that support and benefit the people of Africa. The journal was previously publishd as Bothalia, and had served the South African botanical community since 1921. However the expande mandate of SANBI necessitated a broader scope for the journal, and in 2017, the subtitle, African Biodiversity & Conservation was added to reflect this change.
Medicago truncatula Genome Database | J. Craig Venter InstituteMedicago truncatula Genome Database | J. Craig Venter Institute
JCVI hosts the M. truncatula genome sequence and annotation in three forms: a Tripal database, JBrowse and an instance of InterMine named MedicMine. These databases also form part of a larger consortium of legume databases known as the Legume Federation (legumefederation.org). The Legume Federation is a joint project with USDA-ARS-Iowa State and the National Center for Genome Resources. Together, these three centers house genomic, genetic and phenotypic (QTL) data for around 10 legume crop species including soybean, common bean, peanut, chickpea, clover, lupin and others. The goal of the project is to provide cross-species links between these plants at the genomic, genetic and phenotypic levels to further legume research and breeding.. ...
White Clover (Trifolium repens) - 04 - Wild Flowers of Sleepy Hollow Lake From All-Creatures.orgWhite Clover (Trifolium repens) - 04 - Wild Flowers of Sleepy Hollow Lake From All-Creatures.org
White Clover (Trifolium repens) - Wild Flowers of Sleepy Hollow Lake - Working for a peaceful world for humans, animals, and the environment
The Marshall-Colon Lab » Amy and Katy funded by NSF to study medicago/rhizobia mutualisms!The Marshall-Colon Lab » Amy and Katy funded by NSF to study medicago/rhizobia mutualisms!
NSF IOS Award #1645875 Systems genetics of symbiotic quality in legume-rhizobium mutualism.. We are going to build "symbiosis networks" using genomic, transcriptomic, and metabolomic data to determine the molecular underpinnings of high and low partner quality in the medicago/sinorhizobium mutualism.. ...
Medicago truncatula chromosome 6 clone mth2-43g7, WORKING DRAFT SEQUEN - Nucleotide - NCBIMedicago truncatula chromosome 6 clone mth2-43g7, WORKING DRAFT SEQUEN - Nucleotide - NCBI
Finds sub-sequences or patterns in the sequence and highlights the matching regions. The tool works with standard single letter nucleotide or protein codes including ambiguities and can match Prosite patterns in protein sequences. More... ...
DI-fusion Maturation of nematode-induced galls in Medicago truncatula...DI-fusion Maturation of nematode-induced galls in Medicago truncatula...
DI-fusion, le Dépôt institutionnel numérique de lULB, est loutil de référencementde la production scientifique de lULB.Linterface de recherche DI-fusion permet de consulter les publications des chercheurs de lULB et les thèses qui y ont été défendues.
Arabidopsis TAC clones « Experimental Plant Division (RIKEN BRC)Arabidopsis TAC clones « Experimental Plant Division (RIKEN BRC)
Following manuscript should be referred in the publication on a scientific journal.1. Liu YG, Shirano Y, Fukaki H, Yanai Y, Tasaka M, Tabata S, Shibata D. Complementation of plant mutants with large genomic DNA fragments by atransformation-competent artificial chromosome vector accelerates positionalcloning. Proc Natl Acad Sci U S A. 1999 May 25;96(11):6535-40. PubMed PMID:10339623 ...
Legume Information SystemLegume Information System
New genome browser for Medicago build 3.5.1. The focus is on relationships with other genomes. Added Medicago truncatula genome build 3.5.1 to Seqqle pages. This supports link-outs to the new Mt GBrowse site (above). Seqqle search reports now include full genome summaries depicting the mapping of query sequences onto the chromosomes of Gm, Lj, and Mt using the new Genome Drawing Engine and the Comparative Map and Trait Viewer.. Read More ». ...
Medicago arborea (Tree Medick) | BioLib.czMedicago arborea (Tree Medick) | BioLib.cz
Help us to expand this encyclopedia! If you are logged in, you can add new subtaxa, vernacular and scientific names, texts, images or intertaxon relationships for this taxon ...
Gene-silencing-induced changes in carbohydrate conformation in relation to bioenergy value and carbohydrate subfractions in...Gene-silencing-induced changes in carbohydrate conformation in relation to bioenergy value and carbohydrate subfractions in...
Gene silencing with RNA interference (RNAi) technology may be capable of modifying internal structure at a molecular level. This structural modification could affect biofunctions in terms of biodegradation, biochemical metabolism, and bioactive compound availability. The objectives of this study were to (1) Detect gene silencing-induced changes in carbohydrate molecular structure in an alfalfa forage (Medicago sativa spp. sativa: alfalfa) with down-regulation of genes that encode transcription factors TT8 and HB12; (2) Determine gene silencing-induced changes in nutrient bioutilization and bioavailability in the alfalfa forage (Medicago sativa); and (3) Quantify the correlation between gene silencing-induced molecular structure changes and the nutrient bioutilization and bioavailability in animals of ruminants. The experimental treatments included: T1 = Non-transgenic and no-gene silenced alfalfa forage (code "NT"); T2 = HB12-RNAi forage with HB12 gene down regulation (code "HB12"); T3 = ...
Dr. Julia Frugoli, Research In My Lab - Clemson UniversityDr. Julia Frugoli, Research In My Lab - Clemson University
My lab focuses on molecular genetics in the legume model system Medicago truncatula. Our goal is to identify the plant genes, hormones and environmental signals involved in nodule number regulation and construct a signal transduction pathway for this process.
Untersuchungen zur Funktion de - Titel - sundoc MigrationUntersuchungen zur Funktion de - Titel - sundoc Migration
sundoc Migration; Titel: Untersuchungen zur Funktion der mykorrhizainduzierten Apocarotinoide in Wurzeln von Medicago truncatula, Verfasser: Floß, Daniela S., 2008 ; Halle, Saale : Universitäts- und Landesbibliothek Sachsen-Anhalt
Farm Journal - White Clover FarmFarm Journal - White Clover Farm
Welcome to the White Clover Farm Journal. We track our grass fed beef from birth to consumer, to ensure they remain safe and healthy food.
pewit: May 2009pewit: May 2009
for the last week Painted Lady butterflies have been everywhere locally with last weekend seeing a strong northerly movement through the area; with light SE winds today another arrival / movement seems to be underway; most of the ones I saw in the week were simply flying by but this morning some were stopping to feed on clover flowers along the Humber bank; most are old and faded / bleached individuals like the lower two but I did come across this brighter / fresher individual early this morning before the sun got too high ...
Nature ID: four-leaf clover ~ 06/30/11 ~ at homeNature ID: four-leaf clover ~ 06/30/11 ~ at home
It must be my lucky day, times 2! I never thought about what species of clover the "traditional" four-leaf lucky clover is. Ah, I have many fond memories laying in the warm school yard grass with my girlfriends, searching every recess for those 4 leaves of luck. Looking online for information was entertaining. Heres a "how-to" from wikiHow and its corresponding luck link - numbers 10 and 12 hold especially true for Nature ID. May you have the blessings of luck ...
Magiran | مجله به زراعی کشاورزی، سال بیست و یکم شماره 4 (زمستان 1398)Magiran | مجله به زراعی کشاورزی، سال بیست و یکم شماره 4 (زمستان 1398)
به منظور بررسی اثر شبدر ایرانی (Trifolium resupinatum L.) به عنوان گیاه پوششی در کنترل علفهای هرز کلزای پاییزه، آزمایشی بصورت مزرعه ای در قالب طرح بلوک کامل تصادفی با چهار تکرار در سال زراعی 1397-1396 در کیلومتر 35 نهاوند اجرا شد. شش تیمار شامل کاشت کلزای خالص (با و بدون علف هرز) و کلزا همراه با 25، 50، 75 و 100 درصد میزان کشت مطلوب شبدر (50 کیلوگرم در هکتار) به صورت افزایشی بودند. نتایج نشان داد که کاربرد گیاه پوششی اثر معنی داری در کاهش تراکم و وزن خشک علف های هرز در مقایسه با شاهد (تداخل تمام فصل با علف های هرز) دارد. به طوریکه تیمارهای کلزا+25، 50، 75 و 100 درصد تراکم مطلوب شبدر ایرانی ...
Genome sequence of Ensifer meliloti strain WSM1022, a highly effective microsymbiont of the model legume Medicago truncatula...Genome sequence of Ensifer meliloti strain WSM1022, a highly effective microsymbiont of the model legume Medicago truncatula...
Ensifer meliloti WSM1022 is an aerobic, motile, Gram-negative, non-spore-forming rod that can exist as a soil saprophyte or as a legume microsymbiont of Medicago. WSM1022 was isolated in 1987 from a nodule recovered from the roots of the annual Medicago orbicularis growing on the Cyclades Island of Naxos in Greece. WSM1022 is highly effective at fixing nitrogen with M. truncatula and other annual species such as M. tornata and M. littoralis and is also highly effective with the perennial M. sativa (alfalfa or lucerne). In common with other characterized E. meliloti strains, WSM1022 will nodulate but fixes poorly with M. polymorpha and M. sphaerocarpos and does not nodulate M. murex. Here we describe the features of E. meliloti WSM1022, together with genome sequence information and its annotation. The 6,649,661 bp high-quality-draft genome is arranged into 121 scaffolds of 125 contigs containing 6,323 protein-coding genes and 75 RNA-only encoding genes, and is one of 100 rhizobial genomes ...
Molecular interactions between medicago truncatula and macrophomina phaseolinaMolecular interactions between medicago truncatula and macrophomina phaseolina
Macrophomina phaseolina is a soil-borne fungal pathogen that causes a disease commonly known as charcoal rot. Currently, there is not an effective method for controlling the disease, because knowledge about the pathogen, the development of the disease and how it interacts with the plant host is limited. Therefore, a study is proposed to investigate the interactions between M. phaseolina and the plant species Medicago truncatula using a molecular genetics approach where the host genes involved in the disease development will be identified. We will first conduct a genetic screen in a mutant population of M. truncatula and look for strains that have altered susceptibility to M. phaseolina. We will then identify the genes that are involved in host-pathogen interactions ...
Medicago Inc. and Mitsubishi Tanabe Pharma Corporation Enter into a Strategic Alliance to Develop New Vaccines | AfricaBusiness...Medicago Inc. and Mitsubishi Tanabe Pharma Corporation Enter into a Strategic Alliance to Develop New Vaccines | AfricaBusiness...
Medicago to Receive up to $33 Million in Upfront and Milestone Payments as well as Royalties under a First Agreement to Develop a Rotavirus Vaccine QUEBEC CITY, March 6, 2012 /PRNewswire/ - Medicago Inc. (TSX: MDG), a biopharmaceutical company focused on developing highly effective and competitive vaccines based on proprietary manufacturing technologies and Virus-Like Particles (VLPs), today announced the establishment of a strategic alliance with Mitsubishi Tanabe Pharma Corporation (MTPC) through the execution of a Master Research Collaboration Agreement. The objectives are to develop and commercialize at least three new vaccines with MTPC who will provide funding for all research and development costs. In exchange for granting licensing rights, Medicago will be entitled to receive upfront and milestone payments as well as royalties for each product to be developed under this master agreement.. Under this first agreement to develop a Rotavirus Like Particle (RLP) vaccine target, MTPC will have ...
Exploring the nuclear proteome of Medicago truncatula at the switch towards seed fillingExploring the nuclear proteome of Medicago truncatula at the switch towards seed filling
Repetto, O., Rogniaux, H., Firnhaber, C., Zuber, H., Kuester, H., Larre, C., Thompson, R., et al. (2008). Exploring the nuclear proteome of Medicago truncatula at the switch towards seed filling. PLANT JOURNAL, 56(3), 398-410. doi:10.1111/j.1365-313X.2008.03610. ...
Medicago sativa MsPRP2 protein Summary Report | CureHunterMedicago sativa MsPRP2 protein Summary Report | CureHunter
Medicago sativa MsPRP2 protein: a proline-rich cell wall protein; from alfalfa Medicago sativa; amino acid sequence given in first source; GenBank L37017
xseA - Exodeoxyribonuclease 7 large subunit - Rhizobium leguminosarum bv. trifolii (strain WSM2304) - xseA gene & proteinxseA - Exodeoxyribonuclease 7 large subunit - Rhizobium leguminosarum bv. trifolii (strain WSM2304) - xseA gene & protein
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
Buy Herbalhills Alfalfa 60 Ct Medicago Sativa Tablets (Switzerland Free Shipping)Buy Herbalhills Alfalfa 60 Ct Medicago Sativa Tablets (Switzerland Free Shipping)
Certified Organically Grown (C.O.G.) * Natural source of Chlorophyll & Vitamins * Natural source of Minerals and Protein Alfalfas (Medicago sativa) deep root system pulls valuable minerals from the soil. With the aid of sun light, nutrients inclu
Buy Herbalhills Alfalfa 60 Ct Medicago Sativa Tablets (Ireland - Europe Free Shipping)Buy Herbalhills Alfalfa 60 Ct Medicago Sativa Tablets (Ireland - Europe Free Shipping)
Certified Organically Grown (C.O.G.) * Natural source of Chlorophyll & Vitamins * Natural source of Minerals and Protein Alfalfas (Medicago sativa) deep root system pulls valuable minerals from the soil. With the aid of sun light, nutrients inclu
Role of p21ras in growth factor signal transduction | Biochemical Society TransactionsRole of p21ras in growth factor signal transduction | Biochemical Society Transactions
Thank you for your interest in spreading the word about Biochemical Society Transactions.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
Protein-protein interactions - Institute of Plant Genetics - Leibniz University HannoverProtein-protein interactions - Institute of Plant Genetics - Leibniz University Hannover
Regulatory networks controling the initiation and development of an arbuscular mycorrhiza (AM) symbiosis involve the interaction of different classes of transcription factors (TFs), primarily belonging to the NF-Y, GRAS, AP2/ERF, and Myb categories. To identify protein-protein interactions amongst selected, AM-activated TFs as well as between those TFs and their target promoters, yeast-2-hybrid (Y2H) and yeast-1-hybrid (Y1H) experiments are performed. To verify such protein-protein interactions in planta, split-YFP fusions of selected, AM-activated TFs are expressed in transgenic Medicago truncatula roots or Nicotiana benthamiana leaves.. ...
Medicago breaks ground on tobacco leaf vaccine facility | Vaccine NewsMedicago breaks ground on tobacco leaf vaccine facility | Vaccine News
The biotech firm Medicago USA Inc., based in Quebec City, Canada, recently broke ground on a planned 90,000-square-foot facility in Durham, North Carolina, that will make influenza vaccines using tobacco leaves.
A Tobacco-Based COVID-19 Vaccine? | SFNToday.comA Tobacco-Based COVID-19 Vaccine? | SFNToday.com
Some might call it an organic approach to fighting COVID 19. A Canadian company is in the final stages of testing a plant-based COVID-19 virus vaccine that they hope can get approval for distribution later this year. Medicago, based near Quebec City, is using chloroplast proteins found in a plant within the tobacco family and native to Australia.. Using plant-chloroplast to create vaccines is not new, as the approach has been used to fight both viral and bacterial diseases. Plant-based virus fighting vaccines include rotavirus in humans and parvovirus in animals. Its bacterial disease vaccines including cholera, Lyme disease, anthrax and tetanus.. Dr. Nathalie Charland, a Medicago with Medicago, says the company is currently in phase three testing of its human trials. She said that, like most of the COVID vaccines already approved, this plant- based vaccine requires two doses, 21 days apart. But she says the Medicago vaccine is inherently different because it does not include COVID 19 genetic ...
User:Marcel Quint/Notebook/medicago/2008 - OpenWetWareUser:Marcel Quint/Notebook/medicago/2008 - OpenWetWare
sibboleth --,,div id=y1 style=border:0px;,,div style=display:none; id=id,y1,/div,,div style=display:none; id=dtext,04/23/2008,04/24/2008,04/25/2008,04/26/2008,04/28/2008,04/29/2008,05/05/2008,05/28/2008,05/29/2008,/div,,div style=display:none; id=page,User:Marcel Quint/Notebook/medicago,/div,,div style=display:none; id=fmt,yyyy/MM/dd,/div,,div style=display:none; id=css,OWWNB,/div,,div style=display:none; id=month,1,/div,,div style=display:none; id=year,2008,/div,,div style=display:none; id=readonly,Y,/div,,/div ...
Medicago rugosa imagesMedicago rugosa images
This page highlights species images RE: Medicago rugosa from the Pacific Island Ecosystems at Risk project (PIER) (http://www.hear.org/pier/).
Author: Chen, Rujin - PubAg Search ResultsAuthor: 'Chen, Rujin' - PubAg Search Results
Plant organs such as seeds are primary sources of food for both humans and animals. Seed size is one of the major agronomic traits that have been selected in crop plants during their domestication. Legume seeds are a major source of dietary proteins and oils. Here, we report a novel and conserved role for BIG SEEDS1 (BS1) gene in the control of seed size and weight in the model legume Medicago tru ...
Avg file server edition 2013 download - Hosting BlogAvg file server edition 2013 download - Hosting Blog
Servint. They can also be useful for quick exploration and testing of new components: operating systems, frameworks, software, etc. Simply try us for 30 days risk-free. To clarify the mechanisms of symbiotic cell adaptation to intracellular bacteria, we first quantified cell, vacuole, and microsymbiont surface-volume dynamics during nodule development. ESTs sharing significant identity were also identified in mouse, rat, bovine, and pig databases. Choose a host that uses virtual private servers. Virtual Private Servers from Knownhost give you the flexibility, security and performance you need to run your website with added peace of mind. Web hosting accounting software, the mechanisms that enable the opportunistic fungus to become pathogenic have not been revealed yet. Your data is stored on access protected storage networks and is always available even if one storage node fails. If you need hosting for a short time periodвsay, less than a month or twoвyoull typically receive a refund should ...
Lobbying Spending Database - Medicago, 2017 | OpenSecretsLobbying Spending Database - Medicago, 2017 | OpenSecrets
Explore the billions of dollars special interest groups are spending on lobbying in Washington, D.C., -- and on what -- at OpenSecrets.org.
White clover | Pasture Improvement InitiativeWhite clover | Pasture Improvement Initiative
Preferred soils: White clover is suited to a wide range of soils pH , 4.5; optimum 5.3. Tolerates low exchangeable aluminium and poorly-drained soils. Well suited to peaty soil.. Suitable companion species:. ...
Bisporella citrinaBisporella citrina
Specimen Code: CUP-LP-000265; Determined By: J.F. Babcock; Date Determined: Sep 22,1999; Slant: no; -80° C Freezer: no; Herbarium: CCFB; d H2O: n/a; Collected By: J.F. Babcock; Date(s) Collected: 20 Sep 1999; Soil type: HdD; Source: on dead wood; Locality Code: Sector 8; Locality Name: Lindsay-Parsons Biodiversity Preserve; Township: West Danby, Tompkins Co.; State: NY; Country: USA; Elevation: 950 ft.-1050 ft.; Loc Latitude: 42°1853N; Loc Longitude: 76°3043W ...
Red Clover Extract Review - Derived From The Red Clover Plant AndRed Clover Extract Review - Derived From The Red Clover Plant And
Red Clover Extract has a recommended dosage of Red Clover Extract may be consumed at 40mg taken once daily or twice daily totalling at 80mg per day...
euskara | Txantxangorria-Euskal karaokeak - Part 2euskara | Txantxangorria-Euskal karaokeak - Part 2
Karaoke hau ahotsarekin: https://www.youtube.com/watch?v=t3pNc669RJk Nork esan du, ezinezkoa da? Nork onartu du,hori hala dela? Zaila bada,ez da ezinezkoa, zaila bada,badago lortzea Eta eroriz ikasten bada oinez has gaitezen bidea egiten. Ez gaitu inork geldituko Ez gaitu inork geldituko Nork esan du, ez dago lortzerik? Nork esan du, ez dut gaitasunik?… Read more"Ez gaitu inork geldituko (URTZ) Ahotsbakoa". ...
SAUSA300 1009 - AureoWikiSAUSA300 1009 - AureoWiki
Staphylococcus aureus; strain: USA300_FPR3757; locus tag: SAUSA300_1009 (SAUSA300_RS05430); symbol: typA; product: GTP-binding protein
12. Trifolium [Tourn.] L. Sp. Pl. 764. 1753. Part 412. Trifolium [Tourn.] L. Sp. Pl. 764. 1753. Part 4
7. Trifolium Medium L. Zig-Zag Or Mammoth Clover. Cow- Or Marl-Grass Fig. 2480 T. medium L. Amoen. Acad. 4: 105. 1759. Closely resembling the preceding species. Stem sometimes conspicuously z...
Delicious New Campaign For Clover - Topic Research, Trends and SurveysDelicious New Campaign For Clover - Topic Research, Trends and Surveys
Special Report on delicious new campaign for clover, along with research on current topics, trends and surveys relating to Delicious New Campaign For Clover
Trifolium -- Discover LifeTrifolium -- Discover Life
Discover Lifes page about the biology, natural history, ecology, identification and distribution of Trifolium -- Discover Life
CLOVERS <span class=common-angle angle-right p-s...CLOVERS <span class="common-angle angle-right p-s...
Planting clover will help fix extra nitrogen into your soil thus providing your plants with the benefit of this nitrogen. Can be added to gardens, lawns and fields
Clover Park Technical College immunologyClover Park Technical College immunology
Get info about Clover Park Technical College immunology. Nursing is one of the fastest-growing job areas, and for good reason. As the population ages, medical care will continue to expand rapidly.
Calflora: Trifolium gymnocarponCalflora: Trifolium gymnocarpon
Available: http://www.calflora.org/ (Accessed: Dec 14, 2017). The information on this page comes from diverse sources. None of the links are sponsored. ...
Lime-speck pugLime-speck pug
List of organisms by chromosome countList of organisms by chromosome count
Pewsey DownsPewsey Downs
Euptoieta claudiaEuptoieta claudia
Monarch butterflyMonarch butterfly
SativumSativum
VegetarianismVegetarianism
ErgocalciferolErgocalciferol
List of the vascular plants in the Red Data Book of RussiaList of the vascular plants in the Red Data Book of Russia
Sown Biodiverse PasturesSown Biodiverse Pastures
Cupido alcetasCupido alcetas
Sinorhizobium medicaeSinorhizobium medicae
List of honey plantsList of honey plants
Indicator plantIndicator plant
SinorhizobiumSinorhizobium
Verticillium wiltVerticillium wilt
List of trifoliate plantsList of trifoliate plants
Coleophora hospitiellaColeophora hospitiella
JacalinJacalin
Scaled quailScaled quail
Friedrich Wilhelm NoëFriedrich Wilhelm Noë
Heliomata glareariaHeliomata glarearia
Isoflavone 7-O-methyltransferaseIsoflavone 7-O-methyltransferase
PhytohaemagglutininPhytohaemagglutinin
Agromyza nanaAgromyza nana
Coleophora fuscociliellaColeophora fuscociliella
Sinorhizobium melilotiSinorhizobium meliloti
Coleophora alcyonipennellaColeophora alcyonipennella
Colletotrichum trifoliiColletotrichum trifolii
FabaceaeFabaceae
AnatomyOrganismsChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesTechnology, Industry, AgricultureInformation ScienceHealth Care
Medicago truncatulaMedicagoMedicago sativaSinorhizobium melilotiRoot Nodules, PlantSymbiosisPlant RootsMycorrhizaePlant ProteinsNitrogen FixationGene Expression Regulation, PlantSinorhizobiumWorkloadMelilotusRhizobiumLotusGenome, PlantPlants, Genetically ModifiedAphanomycesFabaceaeTrifoliumMolecular Sequence DataDNA, PlantSeedsPlant LeavesSyntenyPhylogenyProanthocyanidinsExpressed Sequence TagsRNA, PlantTrigonellaPlant ShootsSeedlingIndoleacetic AcidsLeghemoglobinChromosomes, PlantGlomeromycotaPlant DiseasesCytokininsPeasAgrobacteriumPlant Growth RegulatorsLigninEthylenesPlant StructuresRhizobiaceaePlant StemsNaphthaleneacetic AcidsColletotrichumAmino Acid SequencePhenotypeMeristemCicerGene Expression ProfilingPlant EpidermisLupinusPulvinusSoybeansGerminationAphidsChromosome MappingEntomophthoraMutationFlowersNitrogenThioredoxin hMultigene FamilyOrobanchePlant TumorsGlutamate Synthase (NADH)Sequence Analysis, DNALens PlantPhloemPhaseolusPlant Vascular BundleBase SequencePterocarpansSequence AlignmentSequence Homology, Amino AcidArachis hypogaeaCotyledon
Medicago intertexta - Wikimedia CommonsMedicago intertexta - Wikimedia Commons
Medicago sativaMedicago sativa
Medicago - WikipediaMedicago - Wikipedia
annexin D1 [Medicago truncatula] - Protein - NCBIannexin D1 [Medicago truncatula] - Protein - NCBI
Lobbying Spending Database - Medicago, 2017 | OpenSecretsLobbying Spending Database - Medicago, 2017 | OpenSecrets
Medicago noeana - WikipediaMedicago noeana - Wikipedia
Genome-Wide Medicago truncatula Small RNA Analysis Revealed Novel MicroRNAs and Isoforms Differentially Regulated in Roots and...Genome-Wide Medicago truncatula Small RNA Analysis Revealed Novel MicroRNAs and Isoforms Differentially Regulated in Roots and...
Medicago -- Discover LifeMedicago -- Discover Life
myb-like protein A [Medicago truncatula] - Protein - NCBImyb-like protein A [Medicago truncatula] - Protein - NCBI
Functional Genomics in Medicago truncatula | SpringerLinkFunctional Genomics in Medicago truncatula | SpringerLink
Plants Profile for Medicago polymorpha (burclover)Plants Profile for Medicago polymorpha (burclover)
The Multiple Faces of the Medicago-Sinorhizobium Symbiosis | SpringerLinkThe Multiple Faces of the Medicago-Sinorhizobium Symbiosis | SpringerLink
Plants Profile for Medicago lupulina (black medick)Plants Profile for Medicago lupulina (black medick)
Medicago phrygia - WikispeciesMedicago phrygia - Wikispecies
Medicago falcata - definition of Medicago falcata by The Free DictionaryMedicago falcata - definition of Medicago falcata by The Free Dictionary
Medicago] publications using Medicago genome infoMedicago] publications using Medicago genome info
Physiological, Cytological and Biochemical Stability of Medicago ...: Ingenta ConnectPhysiological, Cytological and Biochemical Stability of Medicago ...: Ingenta Connect
Medicago] 24th Stadler Symposium Genomics of DiseaseMedicago] 24th Stadler Symposium Genomics of Disease
Medicago truncatula Genome Project :: Mutant Information :: ReferencesMedicago truncatula Genome Project :: Mutant Information :: References
Browse Products Containing: MEDICAGO SATIVA (ALFALFA) EXTRACT || Skin Deep® Cosmetics Database | EWGBrowse Products Containing: MEDICAGO SATIVA (ALFALFA) EXTRACT || Skin Deep® Cosmetics Database | EWG
Medicago truncatula Genome Database | J. Craig Venter InstituteMedicago truncatula Genome Database | J. Craig Venter Institute
Medicago sativa Alfalfa, Yellow alfalfa PFAF Plant DatabaseMedicago sativa Alfalfa, Yellow alfalfa PFAF Plant Database
The Model Legume Medicago truncatula | Molecular Microbiology | Microbiology & Virology | Life Sciences | Subjects | WileyThe Model Legume Medicago truncatula | Molecular Microbiology | Microbiology & Virology | Life Sciences | Subjects | Wiley
The Model Legume Medicago truncatula | Molecular Microbiology | Microbiology & Virology | Life Sciences | Subjects | WileyThe Model Legume Medicago truncatula | Molecular Microbiology | Microbiology & Virology | Life Sciences | Subjects | Wiley
IFR - Isoflavone reductase - Medicago sativa (Alfalfa) - IFR gene & proteinIFR - Isoflavone reductase - Medicago sativa (Alfalfa) - IFR gene & protein
11441433 - Annexin - Medicago truncatula (Barrel medic) - 11441433 gene & protein11441433 - Annexin - Medicago truncatula (Barrel medic) - 11441433 gene & protein
Medicagos Innovative Vaccine Production Using Tobacco PlantsMedicago's Innovative Vaccine Production Using Tobacco Plants
Medicago | definition of Medicago by Medical dictionaryMedicago | definition of Medicago by Medical dictionary
MsPG3, a Medicago sativa polygalacturonase gene expressed during the alfalfa-Rhizobium meliloti interaction | PNASMsPG3, a Medicago sativa polygalacturonase gene expressed during the alfalfa-Rhizobium meliloti interaction | PNAS
Medicago announces technological milestone with production of self-assembled Influenza Virus-LikeMedicago announces technological milestone with production of self-assembled Influenza Virus-Like
AnatomyOrganismsChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesTechnology, Industry, AgricultureInformation ScienceHealth Care
Medicago truncatulaMedicagoMedicago sativaSinorhizobium melilotiRoot Nodules, PlantSymbiosisPlant RootsMycorrhizaePlant ProteinsNitrogen FixationGene Expression Regulation, PlantSinorhizobiumWorkloadMelilotusRhizobiumLotusGenome, PlantPlants, Genetically ModifiedAphanomycesFabaceaeTrifoliumMolecular Sequence DataDNA, PlantSeedsPlant LeavesSyntenyPhylogenyProanthocyanidinsExpressed Sequence TagsRNA, PlantTrigonellaPlant ShootsSeedlingIndoleacetic AcidsLeghemoglobinChromosomes, PlantGlomeromycotaPlant DiseasesCytokininsPeasAgrobacteriumPlant Growth RegulatorsLigninEthylenesPlant StructuresRhizobiaceaePlant StemsNaphthaleneacetic AcidsColletotrichumAmino Acid SequencePhenotypeMeristemCicerGene Expression ProfilingPlant EpidermisLupinusPulvinusSoybeansGerminationAphidsChromosome MappingEntomophthoraMutationFlowersNitrogenThioredoxin hMultigene FamilyOrobanchePlant TumorsGlutamate Synthase (NADH)Sequence Analysis, DNALens PlantPhloemPhaseolusPlant Vascular BundleBase SequencePterocarpansSequence AlignmentSequence Homology, Amino AcidArachis hypogaeaCotyledon
AlfalfaLegumeLucerneGenusSpeciesSymbiosisLupulinaChief Executive Officer oLegumesNodulationGenesNodulesProteinGenePolymorphaSinorhizobiumAndy SheldonSymbioticGenomicsRugosaVaccineGeneticsNoduleTruncatula genomeSequencing MedicagoBoissGaertnBiopharmaceutical companyModelRootsQUEBEC CITYGenome DataBaseLotusDevelopmentalVirus-Like ParMetabolismFalcataArabicaArboreaIntertextaMutantWilldVaccinesCultivars
Alfalfa26
Legume18
Lucerne5
  • Effects of replacing lucerne (Medicago sativa L.) hay with fresh citrus pulp on ruminal fermentation and ewe performance. (thefreelibrary.com)
  • 2009) the energy and protein values of lucerne ( Medicago sativa L.) hay in South Africa could vary considerably and should be determined beforehand in order to accurately compose a balanced diet. (scielo.org.za)
  • Six hundred lucerne ( Medicago sativa L.) hay samples were collected from several commercial irrigation farms in the main lucerne producing areas in South Africa, which varied in location, soil characteristics (texture, organic matter, N content, pH) and farm management. (scielo.org.za)
  • Lucerne (Medicago sativa L.) has a considerable amount of genetic diversity for many agronomic and physiological traits. (edu.au)
  • The establishment and growth of 'Stamina 5' lucerne (Medicago sativa) seed sown with three inoculant carriers (ALOSCA®, coated, and peat slurry treated) or as bare seed (control) on five dates (21 October 2010, 9 November 2010, 8 December 2010, 13 January 2011 and 3 February 2011) was investigated on a Lismore stony silt loam soil at Ashley Dene dryland research farm in Canterbury. (lincoln.ac.nz)
Genus6
Species11
  • 2005) constructed a molecular phylogeny of 23 Sinorhizobium strains and tested the symbiotic ability of six strains with 35 Medicago species. (wikipedia.org)
  • Furthermore, they propose that the geographical distribution of strains limits the distribution of particular Medicago species. (wikipedia.org)
  • Medicago species synthesize a variety of bioactive natural products that are used to engage into symbiotic interactions but also serve to deter pathogens and herbivores. (rsc.org)
  • In this review, we focus on the two most interesting and well characterized secondary metabolite classes found in Medicago species, the triterpene saponins and the flavonoids, with a detailed overview of their biosynthesis, regulation, and profiling methods. (rsc.org)
  • It is intended to provide background information on the biology of Medicago sativa L. , its centre of origin, its related species and the potential for gene introgression from M. sativa L. into relatives, and details of the life forms with which it may interact. (agr.ca)
  • For more information on this plant species, see Hank's page on Medicago polymorpha (opens in a new tab). (cabezaprieta.org)
  • Blondon F, Marie D, Brown S, Kondorosi A (1994) Genome size and base composition in Medicago sativa and M. truncatula species. (springer.com)
  • Comparative transcriptome analysis of Medicago versus Arabidopsis revealed significant divergence in developmental expression profiles of orthologous genes, which indicates that phylogenetic analysis alone is insufficient to predict the function of orthologs in different species. (deepdyve.com)
  • Background: Saponins from Medicago species display several biological activities, among them apoptotic effects against plant cells have been evidenced. (eurekaselect.com)
  • Objective: To explore the cytotoxic properties of saponin from Medicago species against animal cells and their effect in combination with the antitumoral drug cisplatin. (eurekaselect.com)
  • Moreover saponins from Medicago species have evidenced interesting properties to mediate cisplatin effects in tumor cell lines. (eurekaselect.com)
Symbiosis2
Lupulina4
Chief Executive Officer o2
  • This is an excellent result and a major milestone for Medicago," said Andy Sheldon, President and Chief Executive Officer of Medicago. (newswire.ca)
  • It is very gratifying to see that our technology is again being recognized as innovative in our industry", said Bruce Clark , President & Chief Executive Officer of Medicago. (biospace.com)
Legumes5
Nodulation6
Genes4
Nodules1
  • It was found that inside Medicago truncatula nodules, NFP and LYK3 localize at the cell periphery in a narrow zone of about two cell layers at the nodule apex. (uva.nl)
Protein4
  • Green forage of Medicago sativa is reported to contain per 100 g, 80.0% moisture, 5.2 g protein, 0.9 g fat, 3.5 g fiber, and 2.4 g ash. (purdue.edu)
  • About Medicago Medicago is a biotechnology company focused on the development, production and commercialization of vaccines and therapeutic protein-based biopharmaceuticals using a proprietary manufacturing system developed from its expertise in the genetic engineering of plants. (newswire.ca)
  • In another related agreement, Medicago licensed a portfolio of plant-based protein development technologies from Philip Morris. (fiercepharma.com)
  • Fig. S3 HyPer protein production in composite plants of Medicago truncatula . (wiley.com)
Gene5
Polymorpha5
Sinorhizobium4
Andy Sheldon4
  • This rapid time frame is critical as it could allow the vaccination of a population before the first wave of the pandemic strikes," said Andy Sheldon, President and CEO of Medicago. (newswire.ca)
  • This trial was the first ever clinical evaluation of a plant-based Influenza VLP vaccine and shows that Medicago's vaccine is safe in humans," said Andy Sheldon, President and CEO of Medicago. (presseportal.de)
  • These additional data expand upon the results we announced in June and support our belief that our influenza vaccines are also capable of providing protection against different circulating viral strains," said Andy Sheldon, President and CEO of Medicago. (bio-medicine.org)
  • Andy Sheldon, the president and CEO of Medicago, told HeraldSun.com that the company plans to tap into the $7 billion pandemic and seasonal flu vaccine markets. (vaccinenewsdaily.com)
Symbiotic1
Genomics1
Rugosa1
Vaccine12
  • Our transient expression system which produces recombinant vaccine antigens in the cells of non-transgenic plants has demonstrated its efficiency and medical potential by successfully producing the H5N1 Avian Influenza vaccine candidate in VLPs," said Dr. Louis Vezina, Chief Scientific Officer of Medicago. (newswire.ca)
  • WASHINGTON, D.C. , April 25, 2019 /PRNewswire/ - Medicago , a Canadian biotech company and global leader in the development and production of plant-derived vaccines, announced today that its proprietary plant-based production platform, Proficia® was named "Best New Vaccine Technology/platform" at the World Vaccine Congress in Washington, D.C. , attended by 1,500 participants including key opinion leaders from the vaccine industry. (biospace.com)
  • QUEBEC CITY, July 15 /CNW/ - Medicago Inc. (TSX-V: MDG) today announced that it will conduct a feasibility study in collaboration with Genopole biopark, in Evry, for the establishment of a vaccine production facility in France. (newswire.ca)
  • Medicago is developing VLP vaccines to protect against H5N1 pandemic influenza, using a transient expression system which produces recombinant vaccine antigens in non-transgenic plants. (newswire.ca)
  • Results at these lower dosage levels have not been reported for an H5N1 vaccine manufactured with a novel vaccine manufacturing technology," said Nathalie Landry, VP Product Development of Medicago. (presseportal.de)
  • Biopharmaceutical firm Medicago has produced a Virus-Like Particle (VLP) of the novel coronavirus, SARS-CoV-2, marking the first step in COVID-19 vaccine development. (pharmaceutical-technology.com)
  • Medicago CEO Dr Bruce Clark said: "The pace of our initial progress in Covid-19 is attributable to the capability of our plant-based platform, which is able to produce vaccine and antibody solutions to counteract this global public health threat. (pharmaceutical-technology.com)
  • Medicago, a biopharmaceutical company headquartered in Quebec City, and GlaxoSmithKline (GSK) are pleased to announce the start of Phase 3 clinical testing of Medicago's plant-derived COVID-19 vaccine candidate in combination with GSK's pandemic adjuvant, as part of the ongoing Phase 2/3 study. (gsk.com)
  • The FDA's decision to grant Fast Track designation for Medicago's vaccine candidate will help us expedite our efforts to bring the first plant-derived COVID-19 vaccine to market, subject to regulatory approval," said Carolyn Finkle, Chief Operating Officer of Medicago. (gsk.com)
  • QUEBEC CITY July 30 / Medicago Inc. (TSX-V: MD...Medicago's H1N1 VLP vaccine was formulated to protect against the infl. (bio-medicine.org)
  • QUEBEC CITY, July 30 /PRNewswire-FirstCall/ - Medicago Inc. (TSX-V: MDG) a biotechnology company focused on developing highly effective and affordable vaccines based on proprietary manufacturing technologies and Virus-Like Particles (VLPs), today announced that it has achieved additional positive results with its vaccine candidate for the Influenza A (H1N1) virus, also known as Swine flu. (bio-medicine.org)
  • In a continuation of this study, Medicago tested the immune response of its H1N1 vaccine against the California/07 virus, a more current and mutated strain and showed positive immune response after a single dose of 5 micrograms. (bio-medicine.org)
Genetics1
  • In this study, the cytology and genetics of resistance to spring black stem and leaf spot caused by Phoma medicaginis , an economically important necrotrophic pathogen of Medicago spp. (biomedcentral.com)
Nodule1
Truncatula genome3
Sequencing Medicago1
Boiss14
Gaertn2
Biopharmaceutical company2
Model2
Roots2
QUEBEC CITY2
  • In 2018, Medicago broke ground on the new $245 million manufacturing complex in Quebec City that will include the company's headquarters, research and development as well as production facilities. (biospace.com)
  • The biotech firm Medicago USA Inc., based in Quebec City, Canada, recently broke ground on a planned 90,000-square-foot facility in Durham, North Carolina, that will make influenza vaccines using tobacco leaves. (vaccinenewsdaily.com)
Genome DataBase1
Lotus5
  • Medicago diverged from Glycine (soybean) about 53-55 million years ago (in the early Eocene), from Lotus (deervetch) 49-51 million years ago (also in the Eocene), and from Trigonella 10-22 million years ago (in the Miocene). (wikipedia.org)
  • Extensive macrosynteny between Lotus and bean was uncovered on 8 of the 11 bean chromosomes and large blocks of macrosynteny were also found between bean and Medicago. (genetics.org)
  • Lotus and Medicago are equally closely related to the bean and equally distantly related to Arachis ( D oyle and L uckow 2003 ). (genetics.org)
  • The Arachis genetic map was substantially aligned with Lotus and Medicago with most synteny blocks presenting a single main affinity to each genome. (biomedcentral.com)
  • We found that in Medicago and possibly also in Lotus , retrotransposons tend to be more frequent in the variable regions. (biomedcentral.com)
Developmental1
Virus-Like Par1
  • About Medicago Medicago is committed to provide highly effective and affordable vaccines based on proprietary Virus-Like Particle (VLP) and manufacturing technologies. (newswire.ca)
Metabolism1
  • Throughout, we critically analyze the current bottlenecks and speculate on future directions and opportunities for research and exploitation of Medicago metabolism. (rsc.org)
Falcata1
Arabica1
Arborea1
  • Medicago arborea L. Medicago citrina (Font Quer) Greuter Medicago strasseri Greuter, Matthas & Risse Medicago hypogaea E. Small Medicago heyniana Greuter Medicago radiata L. Medicago biflora (Griseb. (wikipedia.org)
Intertexta1
Mutant1
Willd3
Vaccines3
  • The next step for Medicago is to demonstrate how its new-product development, based on the same platform, can expand into other areas beyond vaccines, such as those now reserved for antibodies and peptides. (pharmaceuticalonline.com)
  • Medicago also will receive royalty payments on future sales of pandemic and seasonal influenza vaccines in China that use the company's technology. (fiercepharma.com)
  • In addition to flu vaccines, in 2015, Medicago successfully completed a contract with the U.S. government (BARDA) to produce anti-Ebola antibodies. (biospace.com)
Cultivars1
Medicago intertexta - Wikimedia Commons
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How plant microbes could feed the world and save endangered species | Science News
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Receptor-mediated chitin perception in legume roots is functionally separable from Nod factor perception | PNAS
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Functional Genomics in Medicago truncatula | SpringerLink
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Other Mobile Phone Accessories - latest Other Mobile Phone Accessories from Other Mobile Phone Accessories suppliers in China
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