Mediastinal neoplasms. Medical search

Tumors or cancer of the MEDIASTINUM.

Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).

New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.

Neoplasms containing cyst-like formations or producing mucin or serum.

Tumors or cancer of the SKIN.

Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.

Tumors or cancers of the KIDNEY.

Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.

An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)

Tumors or cancer of the THYROID GLAND.

Conditions which cause proliferation of hemopoietically active tissue or of tissue which has embryonic hemopoietic potential. They all involve dysregulation of multipotent MYELOID PROGENITOR CELLS, most often caused by a mutation in the JAK2 PROTEIN TYROSINE KINASE.

DNA present in neoplastic tissue.

Tumors or cancer of the LUNG.

Tumors or cancer of the PAROTID GLAND.

A benign neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. In some instances, considerable portions of the neoplasm, or even the entire mass, may be cystic. (Stedman, 25th ed)

Neoplasms developing from some structure of the connective and subcutaneous tissue. The concept does not refer to neoplasms located in connective or soft tissue.

Neoplasms associated with a proliferation of a single clone of PLASMA CELLS and characterized by the secretion of PARAPROTEINS.

Tumors or cancer of the APPENDIX.

Tumors or cancer of the LIVER.

A multilocular tumor with mucin secreting epithelium. They are most often found in the ovary, but are also found in the pancreas, appendix, and rarely, retroperitoneal and in the urinary bladder. They are considered to have low-grade malignant potential.

Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.

Tumors or cancer of the ENDOCRINE GLANDS.

Tumors or cancer of the GASTROINTESTINAL TRACT, from the MOUTH to the ANAL CANAL.

Carcinoma that arises from the PANCREATIC DUCTS. It accounts for the majority of cancers derived from the PANCREAS.

Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.

Neoplasms composed of vascular tissue. This concept does not refer to neoplasms located in blood vessels.

Tumors or cancer of the EYE.

Histochemical localization of immunoreactive substances using labeled antibodies as reagents.

Tumors or cancer of the NOSE.

Tumors or cancer of the SALIVARY GLANDS.

Tumors, cancer or other neoplasms produced by exposure to ionizing or non-ionizing radiation.

An adenocarcinoma containing finger-like processes of vascular connective tissue covered by neoplastic epithelium, projecting into cysts or the cavity of glands or follicles. It occurs most frequently in the ovary and thyroid gland. (Stedman, 25th ed)

A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (Stedman, 25th ed)

Tumors or cancer of the TESTIS. Germ cell tumors (GERMINOMA) of the testis constitute 95% of all testicular neoplasms.

Neoplasms composed of muscle tissue: skeletal, cardiac, or smooth. The concept does not refer to neoplasms located in muscles.

Neoplasms composed of glandular tissue, an aggregation of epithelial cells that elaborate secretions, and of any type of epithelium itself. The concept does not refer to neoplasms located in the various glands or in epithelial tissue.

A malignant cystic or semisolid tumor most often occurring in the ovary. Rarely, one is solid. This tumor may develop from a mucinous cystadenoma, or it may be malignant at the onset. The cysts are lined with tall columnar epithelial cells; in others, the epithelium consists of many layers of cells that have lost normal structure entirely. In the more undifferentiated tumors, one may see sheets and nests of tumor cells that have very little resemblance to the parent structure. (Hughes, Obstetric-Gynecologic Terminology, 1972, p184)

A benign epithelial tumor with a glandular organization.

Neoplasms of whatever cell type or origin, occurring in the extraskeletal connective tissue framework of the body including the organs of locomotion and their various component structures, such as nerves, blood vessels, lymphatics, etc.

Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue). The commonest forms are the various types of LEUKEMIA, of LYMPHOMA, and of the progressive, life-threatening forms of the MYELODYSPLASTIC SYNDROMES.

Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.

Tumors or cancer of the UTERUS.

Tumors or cancer of the INTESTINES.

Neoplasms composed of sebaceous or sweat gland tissue or tissue of other skin appendages. The concept does not refer to neoplasms located in the sebaceous or sweat glands or in the other skin appendages.

Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.

Neoplasms located in the vasculature system, such as ARTERIES and VEINS. They are differentiated from neoplasms of vascular tissue (NEOPLASMS, VASCULAR TISSUE), such as ANGIOFIBROMA or HEMANGIOMA.

A general term for various neoplastic diseases of the lymphoid tissue.

Tumors or cancer located in bone tissue or specific BONES.

Tumors or cancer of the PALATE, including those of the hard palate, soft palate and UVULA.

Neoplasms composed of more than one type of neoplastic tissue.

Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.

Tumors or cancer of the MANDIBLE.

A malignant neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. The neoplastic cells manifest varying degrees of anaplasia and invasiveness, and local extension and metastases occur. Cystadenocarcinomas develop frequently in the ovaries, where pseudomucinous and serous types are recognized. (Stedman, 25th ed)

Tumors or cancer of the BILE DUCTS.

Ability of neoplasms to infiltrate and actively destroy surrounding tissue.

Tumors or cancer of the THYMUS GLAND.

Tumors or cancer of the SPLEEN.

Tumors in any part of the heart. They include primary cardiac tumors and metastatic tumors to the heart. Their interference with normal cardiac functions can cause a wide variety of symptoms including HEART FAILURE; CARDIAC ARRHYTHMIAS; or EMBOLISM.

A cystic tumor of the ovary, containing thin, clear, yellow serous fluid and varying amounts of solid tissue, with a malignant potential several times greater than that of mucinous cystadenoma (CYSTADENOMA, MUCINOUS). It can be unilocular, parvilocular, or multilocular. It is often bilateral and papillary. The cysts may vary greatly in size. (Dorland, 27th ed; from Hughes, Obstetric-Gynecologic Terminology, 1972)

Tumors or cancer of the COLON.

Cancer or tumors of the MAXILLA or upper jaw.

Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.

Diseases of the domestic dog (Canis familiaris). This term does not include diseases of wild dogs, WOLVES; FOXES; and other Canidae for which the heading CARNIVORA is used.

Tumors or cancer of the anal gland.

Neoplasms composed of primordial GERM CELLS of embryonic GONADS or of elements of the germ layers of the EMBRYO, MAMMALIAN. The concept does not refer to neoplasms located in the gonads or present in an embryo or FETUS.

Neoplasms located in the bone marrow. They are differentiated from neoplasms composed of bone marrow cells, such as MULTIPLE MYELOMA. Most bone marrow neoplasms are metastatic.

Neoplasms composed of fatty tissue or connective tissue made up of fat cells in a meshwork of areolar tissue. The concept does not refer to neoplasms located in adipose tissue.

Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.

Benign and malignant neoplastic processes that arise from or secondarily involve the meningeal coverings of the brain and spinal cord.

Tumors or cancer of the DUODENUM.

Tumors or cancers of the ADRENAL CORTEX.

Tumors or cancer of the MOUTH.

Primary mediastinal large B-cell lymphoma: a clinicopathologic study of 43 patients from the Nebraska Lymphoma Study Group. (1/673)

PURPOSE: To investigate whether primary mediastinal large B-cell lymphoma (PMLBL) is a distinct clinicopathologic entity with a more aggressive course than other diffuse large B-cell lymphomas (DLBL). MATERIALS AND METHODS: All patients with CD20-positive DLBL who presented with a mediastinal mass measuring at least 5.0 cm and were treated with curative intent were identified. A control group of 352 patients with nonmediastinal DLBL was selected for comparison. RESULTS: The 43 patients with PMLBL had a male to female ratio of 20:23 and a median age of 42 years. Stage I/II disease was present in 58% of the patients, with only 9% having bone marrow involvement. A complete remission was achieved in 63% of the patients, and the 5-year overall and failure-free survivals were 46% and 38%, respectively. Among the clinical variables, an elevated serum lactate dehydrogenase level, a low performance score, more than one extranodal site, and an intermediate or high International Prognostic Index score were predictive of poor survival. When compared with the DLBL group, a younger median age was the only clinical feature that was significantly different in the PMLBL group. CONCLUSION: The clinical features of PMLBL do not appear to be significantly different from those of nonmediastinal DLBL. Although the younger age of onset, slight female predominance, mediastinal location, and size of the mass may justify the recognition of PMLBL as a clinical syndrome, additional evidence is needed to define it as a distinct disease entity. (+info)

Neuromyotonia: an unusual presentation of intrathoracic malignancy. (2/673)

A 48 year old woman is described who presented with increasing muscular rigidity and who was found to have a mediastinal tumour. Electrophysiological studies revealed that the muscular stiffness resulted from very high frequency motor unit activity which outlasted voluntary effort, and which was abolished by nerve block. The abnormal activity may have arisen at the anterior horn cell level. Marked improvement followed the administration of diphenylhydantoin. (+info)

Diagnostic value of endoscopic ultrasonography-guided fine-needle aspiration cytology of mediastinal masses in patients with intrapulmonary lesions and nondiagnostic bronchoscopy. (3/673)

Several procedures are available for the cytopathological diagnosis of mediastinal lesions. The purpose of this study was to evaluate the diagnostic value of endoscopic ultrasonography (EUS)-guided fine-needle aspiration (FNA) in patients with mediastinal mass lesions/lymph node enlargement. All patients had intrapulmonary lesions on chest X ray and/or CT scan, and inconclusive findings by endobronchial forceps biopsy and/or brush cytology. EUS-guided FNA was performed in 16 patients using a modified oblique forward-viewing gastroscope with an electronic multielement curved linear ultrasound transducer. After the region of interest was localized, a 22-gauge Vilmann-Hancke needle was introduced via the 2-mm biopsy channel. The cytological diagnosis of EUS-guided FNA was conclusive for cancer in 9 patients and in the other 7 patients the aspirated samples revealed a benign lesion. In 10 patients the final diagnosis was cancer, thus EUS-guided FNA was diagnostic for malignancy in all but 1 of the lesions (sensitivity 90.0%). In 1 patient epitheloid cell granuloma was detected by cytological examination of the FNA. Following tuberculostatic treatment the lesions disappeared completely on CT scan and EUS. The overall accuracy in this study amounted to 93.7%. From this and other studies discussed, it is assumed that the procedure is an accurate and safe technique to examine nodular lesions suggestive of metastatic lymph node involvement. (+info)

Primary mediastinal malignancies: findings in 219 patients. (4/673)

The purpose of this study was to determine the demographics, histology, methods of treatment, and survival in primary mediastinal malignancies. We did a retrospective review of the statewide New Mexico Tumor Registry for all malignant tumors treated between January 1, 1973 and December 31, 1995. Benign tumors and cysts of the mediastinum were excluded. Two hundred nineteen patients were identified from a total of 110,284 patients with primary malignancies: 55% of tumors were lymphomas, 16% malignant germ cell tumors, 14% malignant thymomas, 5% sarcomas, 3% malignant neurogenic tumors, and 7% other tumors. There were significant differences in gender between histologies (P < 0.001). Ninety-four percent of germ cell tumors occurred in males, 66% of neurogenic tumors were in females; other tumors occurred in males in 58% of cases. There were also significant differences in ages by histology (P < 0.001). Neurogenic tumors were most common in the first decade, lymphomas and germ cell tumors in the second to fourth decades, and lymphomas and thymomas in patients in their fifth decades and beyond. Stage at presentation (P = 0.001) and treatment (P < 0.001) also differed significantly between histologic groups. Five-year survival was 54% for lymphomas, 51% for malignant germ cell tumors, 49% for malignant thymomas, 33% for sarcomas, 56% for neurogenic tumors, and 51% overall. These survival rates were not statistically different (P > 0.50). Lymphomas, malignant germ cell tumors, and thymomas were the most frequently encountered malignant primary mediastinal neoplasms in this contemporary series of patients. Demographics, stage at presentation, and treatment modality varied significantly by histology. Despite these differences, overall five-year survival was not statistically different. (+info)

Thymic carcinoma of the thymic hormone secretory type in a cow. (5/673)

An 8-year-old Holstein cow had tumor nodules and enlarged lymph nodes in the mediastinum, and metastatic tumor masses in the pelvic cavity. The neoplastic cells were characterized by squamous features and intracytoplasmic vacuoles carrying microvilli, some of which contained periodic acid Schiff-positive globular cores, but tubular structures or goblet cells were absent. Many neoplastic cells stained positively for keratin, and occasional cells were positive for thymosin. The presence of secretory granules in the cytoplasm was confirmed by electron microscopy. This neoplasm was considered to be of thymic hormone-secreting epithelial cell origin. (+info)

Core needle biopsy is effective in the initial diagnosis of mediastinal lymphoma. (6/673)

BACKGROUND AND OBJECTIVE: With the development and refinement of guidance modalities for percutaneous biopsies, many investigators have reported studies supporting the role of guided core needle biopsy in the diagnosis of mediastinal lymphoma. The aims of this report are to evaluate the efficacy of findings at core needle biopsy of mediastinal masses on patient care and define the key determinants of clinical success. DESIGN AND METHODS: Fluoroscopy-guided (in 75 patients) and computed tomography-guided (in 8 patients) core needle biopsies were performed in 83 patients with mediastinal lymphoma: all but one of the patients were at first diagnosis. All the biopsies were performed using a Menghini needle (from 1.2 mm to 1.8 mm). In the vast majority of cases the 1.8 mm gauge was employed. RESULTS: The overall sensitivity for the diagnosis of lymphoma was 81% (67/83 cases). In the remaining 16 patients the lymphoma diagnosis was reached either by mediastinoscopy (11 cases) or anterior mediastinotomy (3 cases) or core needle biopsy of the lung (1 case); one patient was treated directly after the needle biopsy had been unsuccessful because he needed rapid therapy. In 77/82 (93%) patients it was possible to assess the specific histotype. There was no operative mortality; all the biopsies were performed on an outpatient basis. INTERPRETATION AND CONCLUSIONS: Our data indicate that core needle biopsy should be considered as an effective and safe procedure in the diagnosis of patients with mediastinal lymphoma with the possibility of determining the tumor subtype and subsequent specific treatment. (+info)

Diagnostic role of gallium scanning in the management of lymphoma with mediastinal involvement. (7/673)

BACKGROUND AND OBJECTIVE: Therapy of both Hodgkin's disease (HD) and aggressive non-Hodgkin's lymphoma (NHL) with mediastinal presentation at the time of diagnosis is frequently followed by radiological detection of residual masses. Computed tomography (CT) scanning is generally unable to detect the differences between tumor tissue and fibrosis. Gallium-67-citrate single photon emission ((67)GaSPECT) can potentially differentiate residual active tumor tissue from fibrosis. DESIGN AND METHODS: Seventy-five patients with HD or aggressive NHL presenting mediastinal involvement (64% with a bulky mass) were studied with CT and (67)GaSPECT at the end of combined modality therapy (chemo- and radiation therapy). RESULTS: After treatment, 3/3 (100%) patients with positive (67)GaSPECT and negative CT scan relapsed while only 1/18 (6%) patients with both negative (67)GaSPECT and CT scan did so. At the same time, 54 patients had a positive restaging CT scan (abnormal mass < 10% of size of initial mass). Of these patients, 13 had a positive (67)GaSPECT, 10 of whom (77%) relapsed; 41 had a negative (67)GaSPECT of whom 5 (12%) relapsed. The 4-year actuarial relapse-free survival rate was 90% for those with negative scans compared with 23% for gallium-positive patients (p < 0.000000). INTERPRETATION AND CONCLUSIONS: In lymphoma patients with mediastinal involvement, (67)GaSPECT should be considered, at least in patients who are CT positive, the imaging technique of choice for monitoring and differentiating the nature of any residual masses. (+info)

Aggressive primary mediastinal non-Hodgkin's lymphomas: a study of 29 cases. (8/673)

Aggressive primary mediastinal non-Hodgkin's lymphomas (NHL) represent a particular entity among intrathoracic neoplasms. Twenty-nine patients with primary mediastinal aggressive NHL diagnosed and treated in the author's institution were studied. According to the Revised European-American Lymphoma (REAL) classification, there were 15 diffuse large B-cell, eight T-lymphoblastic, four anaplastic, one large T-cell and one Burkitt's lymphomas. The study group consisted of 14 females and 15 males, with a mean age of 38 yrs. Symptoms arose from an aggressive anterior mediastinal mass, with a high prevalence of superior vena caval syndrome, pleural, and pericardial effusions. At the time of diagnosis, disease was confined to supradiaphragmatic areas in 24 patients, while subdiaphragmatic nodal or extranodal involvement was also present in five. All patients received a combination of aggressive chemotherapy regimens, mainly according to the French protocols for the treatment of NHL. A chest radiograph response of <50% after the first course of chemotherapy and failure to achieve a complete remission after the first line of chemotherapy were significantly associated with unfavourable prognosis. Overall 5-yr and 9-yr survival rates were 55 and 48%, respectively. Patients properly diagnosed and treated with a combined modality of chemotherapy can experience prolonged survival. (+info)

Keywords: extra-adrenal paraganglioma, mediastinal neoplasms, metanephrine. Contact Information. [email protected] ... Posterior mediastinal paraganglioma: the experience of Kasr Alainy Thoracic Surgery Unit. Waleed Adel1, Tarek Mohsen1, Ramadan ... Background: Mediastinal paragangliomas are rare tumors with variable clinical presentations and combinations. Having such ... Methods: During seven years, from January 2012 until November 2019, data of eight patients who underwent posterior mediastinal ...

https://www.theinternationalmedicine.com/Main/article_detail.php?id=27

We herein report a case of mediastinal tuberculosis with unusual manifestations.. AB - Mediastinal tuberculous lymphadenitis is ... and it is even rarer for dysphagia to be the presenting symptom of mediastinal tuberculous lymphadenitis. Mediastinal ... and it is even rarer for dysphagia to be the presenting symptom of mediastinal tuberculous lymphadenitis. Mediastinal ... and it is even rarer for dysphagia to be the presenting symptom of mediastinal tuberculous lymphadenitis. Mediastinal ...

https://yonsei.pure.elsevier.com/en/publications/dysphagia-due-to-mediastinal-tuberculous-lymphadenitis-presenting

A 57-year-old man was pointed out the anterior mediastinal tumor when his generator of pacemaker was exchanged. The tumor was ... A 57-year-old man was pointed out the anterior mediastinal tumor when his generator of pacemaker was exchanged. The tumor was ... A 57-year-old man was pointed out the anterior mediastinal tumor when his generator of pacemaker was exchanged. The tumor was ... A 57-year-old man was pointed out the anterior mediastinal tumor when his generator of pacemaker was exchanged. The tumor was ...

https://pure.fujita-hu.ac.jp/en/publications/coexistence-of-sarcoidosis-and-thymic-carcinoid

What are pulmonary carcinoid tumors? These are rare neuroendocrine neoplasms that range from low-grade typical… ... What are neurogenic tumors? Neurogenic tumors are the most common cause of posterior mediastinal masses.… ...

https://www.seekhealthz.com/health/significance-of-silent-and-plurihormonal-pituitary-tumors/

Dr Roden focuses her research on mediastinal neoplasms , lung tumors, malignant mesotheliomas, tumor biomarkers, and nonneoplastic lung diseases, including lung allograft pathology. (thefreedictionary.com)
TNT Uniportal Video-assisted Thoracoscopic Surgery (VATS) has become popular during mediastinal tumors resection. (clinicaltrials.gov)
The aim of our RCT was to evaluate the feasibility and advantage of TNT Uniportal VATS for mediastinal tumors resection and its significance in Fast Track Surgery (FTS). (clinicaltrials.gov)
98 patients aged between 18 and 75 years with clinically mediastinal tumors were randomly assigned to two groups, 50 patients received TNT uniportal VATS mediastinal tumor resection (TNT group) and 48 patients underwent traditional uniportal VATS mediastinal tumor resection (control group), the short-term perioperative outcomes would be reported here. (clinicaltrials.gov)
The term mediastinal gray zone lymphoma (MGZL) has been used for these tumors, which are included in the World Health Organization classification as "B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classic Hodgkin lymphoma. (nih.gov)
Among T-cell neoplasms, MAL was highly expressed in lymphoblastic tumors (5/6), whereas mature T-cell lymphomas were essentially MAL negative (27/28). (nih.gov)
Mediastinal tumors are abnormal growths in your chest. (healthline.com)
Malignant mediastinal germ cell tumors of various histologies were first described as a clinical entity approximately 50 years ago. (health.am)
Mediastinal and other extragonadal germ cell tumors were initially thought to represent isolated metastases from an inapparent gonadal primary site. (health.am)
Extragonadal germ cell tumors, particularly those arising in mediastinal and pineal sites, represent a malignant transformation of germinal elements distributed to these sites and can occur in the absence of a primary focus in the gonad. (health.am)
They are much less common than germinal tumors arising in the testes, and account for only 1 to 5% of all germ cell neoplasms. (health.am)
These figures, most of which are derived from retrospective series reported between 1950 and 1975, may underestimate the true occurance of mediastinal germ cell tumors. (health.am)
The histology of these tumors may be similar to that of other malignant mediastinal tumors, including malignant thymoma and high-grade non-Hodgkin's lymphoma. (health.am)
Although there is no doubt that mediastinal germ cell tumors are uncommon, increasing familiarity with the tumors by both clinicians and pathologists will probably result in their increased recognition. (health.am)
The great majority of mediastinal malignant germ cell tumors occur in patients between 20 and 35 years of age. (health.am)
In the rare occurrences reported in females, mediastinal malignant germ cell tumors have appeared histologically and biologically identical to those occurring in males. (health.am)
In general, mediastinal germ cell tumors appear histologically identical to germ cell tumors arising in the testis, and all histologic subtypes seen in gonadal germ cell neoplasms have also been recognized in the mediastinum. (health.am)
In a recent review of 229 malignant mediastinal germ cell tumors seen between 1960 and 1994 at the Armed Forces Institute of Pathology, pure seminoma was the most common histology, accounting for 52% of cases. (health.am)
The complex anatomy of the mediastinum, as well as the different clinical, radiographic and prognostic features of mediastinal tumors suggests that specialists adopt more flexible and comprehensive practices, as highlighted in this text. (springer.com)
My research in thoracic neoplasms has focused on lung cancer, malignant mesothelioma, and mediastinal thymic tumors. (mskcc.org)
Thymic epithelial tumors (TET) are rare mediastinal neoplasms that can metastasize to the pleural space (stage IVA). (frontiersin.org)
Thymic epithelial tumors (TET) are rare neoplasms, but they are the most frequent anterior mediastinal tumors in adults. (frontiersin.org)
Primary mediastinal tumors. (springer.com)
Kovacs C.M., Gomez-Fernandez C. (2018) Ectopic Thyroid Tumors, Mediastinal. (springer.com)
The 2016 World Health Organization classification of lymphoid neoplasms recommends that immunohistochemistry and/or gene expression profiling be used to subclassify 'typical' DLBCL into tumors of germinal center and non-germinal center origin, in recognition that these two classes of tumors have different prognoses with current therapies [ 1 ]. (uptodate.com)
Gastrointestinal stromal tumors (GISTs) are relatively rare neoplasms of the gastrointestinal tract originating from the pluripotential mesenchymal stem cells, which differentiate into interstitial Cajal cells. (dovepress.com)
Mediastinal teratomata are rare, extragonadal germ cell tumors, which can occur at any age and are often asymptomatic. (cancerindex.org)
Neurogenic tumors, to include nerve sheath and sympathetic ganglion tumors, represent the most common posterior mediastinal masses. (jaocr.org)
Mediastinal germ cell tumors are tumors that derive from germ cell rest remnants in the mediastinum. (wikipedia.org)
Unlike benign germ cell tumors of the mediastinum, malignant mediastinal tumors are usually symptomatic at the time of diagnosis. (wikipedia.org)
Most mediastinal malignant tumors are large and cause symptoms by compressing or invading adjacent structures, including the lungs, pleura, pericardium, and chest wall. (wikipedia.org)
The treatment for mediastinal nonseminomatous germ cell tumors should follow guidelines for poor-prognosis testicular cancer. (wikipedia.org)
Syndromes associated with mediastinal germ cell tumors include Hematologic Neoplasia and Klinefelter's syndrome. (wikipedia.org)
Utility of immunohistochemistry in separating thymic neoplasms from germ cell tumors and metastatic lung cancer involving the anterior mediastinum. (semanticscholar.org)
We report an immunohistochemical (IHC) panel that includes CD5, placental-like alkaline phosphatase (PLAP), thyroid transcription factor 1 (TTF-1), cytokeratin (CK) 7, CK20, CK5/6, and CD57 for the separation of thymic neoplasms from germ cell tumors (GCTs) and metastatic lung malignancies. (semanticscholar.org)
Anterior mediastinal tumors usually arise from the thymus and paravertebral masses usually originate from the nerve sheath. (biomedcentral.com)
The most common mediastinal masses are neurogenic tumors (20% of mediastinal tumors), usually found in the posterior mediastinum, followed by thymoma (15-20%) located in the anterior mediastinum. (wikipedia.org)

Gray zone lymphoma: better treated like hodgkin lymphoma or mediastinal large B-cell lymphoma? (nih.gov)
Although primary mediastinal large B-cell lymphoma (PMBL) and classic Hodgkin lymphoma of the nodular sclerosis type (CHL-NS) are distinct diseases, they share several clinical characteristics and biologic features. (nih.gov)
Using a differential display reverse-transcription approach, we identified MAL as a distinct molecular marker of primary mediastinal large B-cell lymphoma compared with nonmediastinal diffuse large B-cell lymphomas. (nih.gov)
and to the primary mediastinal large B-cell lymphoma derived B-cell line MedB-1. (nih.gov)
In conclusion, this study further supports thymic B cells as the putative normal counterpart of primary mediastinal large B-cell lymphomas and supports MAL as a distinct molecular marker of this lymphoma subtype among diffuse large B-cell lymphomas. (nih.gov)
A cancerous neoplasm in your lymph tissues is referred to as lymphoma . (healthline.com)
Anaplastic large cell lymphoma (ALCL) is a mature T cell neoplasm that often expresses the CD4+ T cell surface marker. (jci.org)
A variant of t(14;18)-negative nodal diffuse follicular lymphoma (FL) with 1p36 deletion has been proposed in the 2017 World Health Organization (WHO) classification of lymphoid neoplasms. (medscape.com)
Primary diffuse large B cell lymphoma of the mediastinum, also called primary mediastinal large B cell lymphoma. (uptodate.com)
See 'Primary mediastinal large B cell lymphoma' . (uptodate.com)
Submit your Twitter account related to Mediastinal Large B-cell Lymphoma to be featured! (novusbio.com)
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Research of Mediastinal Large B-cell Lymphoma has been linked to Lymphoma, B-cell Lymphomas, Mediastinal (thymic) Large B-cell Lymphoma, Diffuse Large B-cell Lymphoma, Mediastinal Neoplasms. (novusbio.com)
The study of Mediastinal Large B-cell Lymphoma has been mentioned in research publications which can be found using our bioinformatics tool below. (novusbio.com)
These pathways complement our catalog of research reagents for the study of Mediastinal Large B-cell Lymphoma including antibodies and ELISA kits against DDIT3, BCL6, MID1, MME, TNFRSF8. (novusbio.com)
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We have 3577 products for the study of Mediastinal Large B-cell Lymphoma that can be applied to Chromatin Immunoprecipitation, Flow Cytometry, Western Blot, Immunocytochemistry/Immunofluorescence, Immunohistochemistry, Chromatin Immunoprecipitation (ChIP) from our catalog of antibodies and ELISA kits. (novusbio.com)
Increased expression of CD30 is observed on some neoplasms including Hodgkin's disease (HD), anaplastic large cell lymphoma (ALCL), mediastinal B cell lymphoma, embryonal carcinoma, seminoma, and mesothelioma ( 2 - 7 ). (pnas.org)
There is also primary mediastinal B-cell lymphoma with exceptionally good prognosis. (wikipedia.org)

Examination of the anterior mediastinal mass biopsy in the 23 year old woman revealed type B1 thymoma which was confirmed after examination of the subsequent robotic thymectomy specimen. (ecu.edu)
The term, thymoma, is customarily used to describe neoplasms that show no overt atypia of the epithelial component. (healthlinkbc.ca)
Thymoma is a neoplasm of thymic epithelial cells. (medscape.com)
Clinical findings - Approximately 50 percent of patients with thymoma are asymptomatic at the time of diagnosis and are discovered incidentally, usually because a chest film or transthoracic echocardiogram obtained for an unrelated purpose is suggestive of an anterior mediastinal mass. 35% of patients present with myasthenia gravis or other tumor related syndromes (see below). (mypacs.net)
Thymoma is the most common neoplasm of the anterior mediastinum, originating within the epithelial cells of the thymus. (psychiatryadvisor.com)
There is a continuum of differentiation from thymoma to thymic carcinoma and primary thymic epithelial neoplasms can have features of both. (psychiatryadvisor.com)

Robotically enhanced mediastinal teratoma resection: a case report and review of the literature. (cancerindex.org)
A large minority of patients with a mediastinal teratoma (including dermoid cyst) will cough up hair. (wikipedia.org)
Background: Mediastinal mature teratoma is a rare primary germ cell neoplasm composed of welldifferentiated tissues derived from more than one of the three embryonic germ cell layers. (amjcaserep.com)
The incidence, etiology and diagnostic procedure of the posterior mediastinal teratoma is discussed. (amjcaserep.com)

Some patients with "poorly differentiated neoplasm" or "poorly differentiated carcinoma" of the mediastinum have the i(12p) chromosomal abnormality diagnostic of germ cell tumor. (health.am)
Metastatic carcinoma of thyroid origin in mediastinal lymph nodes may present as a mass lesion. (springer.com)
Rare presentation of occult medullary carcinoma of the thyroid as a mediastinal mass. (springer.com)
Management of anaplastic thyroid carcinoma spread over the trachea with mediastinal extension. (springer.com)
Mucoepidermoid thymic carcinoma: a challenging mediastinal aspirate. (semanticscholar.org)
In cases of mediastinal lymph node swelling following surgical treatment of urinary tract carcinoma (urothelial carcinoma and renal cell carcinoma), it is imperative that we consider the metastasis of the primary cancer. (elsevier.com)
In cases of mediastinal lymph node swelling following surgical treatment of urinary tract carcinoma, we should make an appropriate use of thoracoscopic lymph node biopsy. (elsevier.com)

Other inclusion criteria included capability of giving consent and adequate organ function to tolerate uniportal thoracoscopy mediastinal tumor resection. (clinicaltrials.gov)
It is indicated for the management of several cardiothoracic diseases, including mediastinal or lung mass resection, drainage of pleural effusions, palliative treatment of critical congenital heart disease and establishment of EXIT-to-extracorporeal membrane oxygenation (ECMO). (signavitae.com)
Patients undergoing oesophageal or cardia resection for cancer are monitored by mediastinal microdialysis during the postoperative period. (knowcancer.com)
Resection and reconstruction of the great mediastinal vessels in case of involved are technically challenging. (ersjournals.com)
After evaluation the patient underwent radical resection of the tumor en bloc with the involved vessels and reconstruction with Y-shaped gore-tex graft. (ersjournals.com)
Currently, resection of anterior mediastinal or paravertebral neoplasm is typically performed using minimally invasive procedures. (biomedcentral.com)
This clinical trial explored intraoperative near-infrared (NIR) imaging as an approach to improving tumor delineation during mediastinal tumor resection. (illinois.edu)

We experienced two cases where thoracoscopic mediastinal lymph node biopsy was successfully used for making a precise diagnosis and providing proper treatmen.The first case enabled a diagnosis of metastasis of urothelial cancer and the second case enabled a diagnosis of primary mediastinal lung cancer (TO lung cancer). (elsevier.com)

Background Anterior mediastinal masses are a rare but well documented finding in Graves disease. (ecu.edu)
The book includes a brief introductory section describing the anatomic sites of mediastinal masses and the epidemiological evidence for each different clinical-pathological entity. (springer.com)
The Mediastinal Mass: A Multidisciplinary Approach provides a valuable resource for clinicians, surgeons, radiologists and pathologists dealing with the management and treatment of mediastinal masses through a multidisciplinary approach. (springer.com)
While chest computed tomography (CT) is the mainstay for initial evaluation of mediastinal masses detected incidentally by radiography or by clinical presentation, CT results are frequently indeterminate. (appliedradiology.com)
Approximately 20% of goiters extend into the thorax, representing roughly 10% of mediastinal masses. (springer.com)
The three-compartment model proposed by Shields ( Figure 1 ) defines the anterior compartment, which lies between the posterior aspect of the sternal plate and the anterior aspect of the great vessels, and contains the thymus, the internal mammary vessels, the extra-pericardial aorta and its branches, the great veins, and lymphatic tissue (a summary of anterior mediastinal masses is found in Table II ). (clinicaladvisor.com)
The middle (visceral) compartment lies between the anterior aspect of the pericardium and the ventral aspect of the thoracic spine and is defined as the heart, the intrapericardial great vessels, the pericardium, and the trachea (a summary of the middle mediastinal masses if found in Table III ). (clinicaladvisor.com)
Most patients with mediastinal masses are asymptomatic, and masses are incidentally found on imaging. (clinicaladvisor.com)
Posterior mediastinal masses can arise from any of these structures. (jaocr.org)
Chest radiography depicted bilateral posterior mediastinal masses (Fig. 1). (thefreelibrary.com)

We conclude that patients with dysphagia and a history of previous mediastinal radiotherapy should undergo repeated endoscopy for biopsy. (symptoma.com)

Biopsy of the anterior mediastinal mass was obtained and subsequently the patient underwent robotic thymectomy. (ecu.edu)

Immunohistochemistry in the diagnosis of thymic epithelial neoplasms. (semanticscholar.org)
Classification of thymic epithelial neoplasms: a controversial issue coming to an end? (wikipedia.org)

Caution should be exercised when dismissing a mediastinal mass as benign thymic hyperplasia in patients with active Graves disease. (ecu.edu)
To properly diagnose neoplastic disease, your doctor will first determine if the neoplasms are benign or malignant. (healthline.com)
If you've been diagnosed with a benign neoplasm, your doctor may want to monitor your symptoms to detect any unusual activity. (healthline.com)
Mediastinal chondroma is a benign mesenchymal neoplasm composed of hyaline cartilage arising as an extraosseal mass in mediastinum. (springer.com)

Thoracic magnetic resonance imaging (MRI) offers a noninvasive way to further characterize mediastinal lesions, their site of origin, and their involvement of adjacent structures. (appliedradiology.com)
This article will discuss MR imaging technique and illustrate how the modality improves diagnostic specificity in mediastinal mass characterization by reviewing the features of selected mediastinal lesions and demonstrating how MR helps narrow the differential diagnosis, often to a single entity. (appliedradiology.com)
Conventional transbronchial needle aspiration (c-TBNA) contributed to improve the bronchoscopic examination, allowing to sample lesions located even outside the tracheo-bronchial tree and in the hilo-mediastinal district, both for diagnostic and staging purposes. (pubmedcentralcanada.ca)
Methods: Twenty-five subjects with anterior mediastinal lesions suspicious for malignancy were enrolled in an open-label feasibility trial. (illinois.edu)

Rare cases of adult onset acute megakaryoblastic leukemia are associated with malignant mediastinal germ cell tumor. (wikipedia.org)
In several of these cases, the genetic aberrations in the malignant megakaryoblasts were similar to those in the malignant mediastinal germ cells. (wikipedia.org)

Lateral radiograph confirmed the posterior location of the mediastinal lesion. (jaocr.org)
An anterior or middle mediastinal location is more common than posterior. (jaocr.org)
Frontal radiographs reveal a posterior mediastinal mass with the aortic shadow not seen separately from the lesion. (jaocr.org)
Extramedullary haematopoiesis: an uncommon posterior mediastinal mass. (thefreelibrary.com)
Only eighteen posterior mediastinal teratomas have been reported to date in the literature. (amjcaserep.com)
Conclusions: Mature cystic teratomas of the posterior mediastinum are distinct clinical entity that must be considered when caring for a patient with a posterior mediastinal mass. (amjcaserep.com)

The thoracic diseases including lung cancer, thymus neoplasm, cardiac surgery disease, aortic aneurysm, and mediastinal tumor of nervous tissue are prevalent. (hindawi.com)
CONCLUSION: In immune type Graves' disease with a mediastinal space-occupying lesion, not only intrathoracic goitre but also thymus hyperplasia should be considered in the differential diagnosis. (uni-regensburg.de)

However, the cardiotoxicity of mediastinal radiation is substantial and the standard treatment of mediastinal seminomas is with chemotherapy using bleomycin, etoposide and cisplatin for either three or four 21-day treatment cycles depending on the location of any metastatic disease. (wikipedia.org)
Treatment of mediastinal Hodgkin's involves chemotherapy and/or radiation. (wikipedia.org)

An anterosuperior mediastinal mass can be caused by neoplastic and non-neoplastic pathology. (radiopaedia.org)

Radiology revealed an upper mediastinal space-occupying lesion which scintigraphically was separate from thyroid tissue. (uni-regensburg.de)
Thyroid neoplasms are. (springer.com)

Mediastinal foregut cysts result from embryologic aberrations with anomalous budding of the primitive foregut. (jaocr.org)

Distant spread can occur to the pleura, the diaphragm, and occasionally the mediastinal lymph nodes. (clinicaladvisor.com)

Among B-cell lymphomas (n = 110), MAL expression in tumor cells was observed in 21/33 primary mediastinal large B-cell lymphomas (70%) and in 3/5 plasmacytoma/myeloma, but not in all other B-cell lymphomas with the exception of 1/33 nonmediastinal diffuse large B-cell lymphomas. (nih.gov)
citation needed] Of all cancers involving the same class of blood cell, 2% of cases are mediastinal large B cell lymphomas. (wikipedia.org)

so far the report of detailed 3D visible thoracic structures' model including lung and mediastinal structures is still not described. (hindawi.com)
We have evaluated the sensitivity, accuracy, positive predictive value (PPV) and negative predictive value (NPV) of the c-TBNA performed during the 2005-2015 period for suspicious lung neoplasia and/or hilar and mediastinal lymphadenopathy at the Thoracic endoscopy of the Thoracic Surgery Department of the Regina Elena National Cancer Institute, Rome. (pubmedcentralcanada.ca)
Intriguingly, the present case suffered from a left-sided thymic tumor and a right-sided lower thoracic paravertebral neoplasm. (biomedcentral.com)

Uncommon primary mediastinal tumours. (springer.com)

Lymphoid neoplasms mostly B or T cell? (studystack.com)

The trial recruited patients aged from 18 to 75 years with a diagnosis of mediastinal tumor. (clinicaltrials.gov)
The c-TBNA proved to be an efficient method for the diagnosis/staging of lung neoplasms and for the diagnosis of mediastinal lymphadenopathy. (pubmedcentralcanada.ca)

Although neuroblastoma (NB) is one of the most common neoplasms in children, the Ministry of Health, Labour, and Welfare opted to halt the mass screening program for NB at 6 months of age in 2004. (omicsonline.org)
Neuroblastoma (NB) is one of the most common neoplasms in children. (omicsonline.org)

There are some potentially life-threatening manifestations of thymomic neoplasms like myasthenia gravis and superior vena cava syndrome. (ersjournals.com)

One in every 17 patients with primary mediastinal non-seminomatous GCTs develop an incurable hematologic malignancy and prior data intriguingly suggests a clonal relationship exists between hematologic malignancies and GCTs in these cases. (jci.org)
Here, we traced the clonal evolution and characterized the genetic features of each neoplasm from a cohort of fifteen patients with GCTs and associated hematologic malignancies. (jci.org)
Hematologic malignancies arising in this setting genetically resembled mediastinal GCTs rather than de novo myeloid neoplasms. (jci.org)
The palliative treatment of the mediastinal malignancies have poor prognosis and radical surgical therapy is the only option. (ersjournals.com)

This case represents a late and uncommon complication of mediastinal irradiation manifesting as a unilateral hyperlucent lung . (symptoma.com)

Symptoms may result from local compression or invasion of adjacent mediastinal structures. (clinicaladvisor.com)
Conversion was required in five cases, mostly for invasion of mediastinal structures. (elsevier.com)
Presence of a large mass, apparently from the middle mediastinum ( white arrows), diameters of 11 x 15 x 12 cm, homogeneous density, with the mass effect on other mediastinal structures (black arrows) and compression on the right upper lobe (*), without inner calcifications. (bvsalud.org)
It is also displacing mediastinal structures such as the trunk of the pulmonary artery (blue arrow), this mass is generating passive atelectasis of the right middle lobe (red arrow). (bvsalud.org)

Cases 12 year old boy with one year history of refractory Graves disease was found to have an anterior mediastinal mass and underwent curative thyroidectomy for sustained hyperthyroidism. (ecu.edu)
A 23 year old woman who presented with a one month history of hyperthyroid symptoms, was diagnosed with Graves disease and also was found to have an anterior mediastinal mass on imaging. (ecu.edu)
These cases indicate that an anterior mediastinal mass in a patient with active Graves disease may be due to a neoplastic cause, which may require definitive treatment. (ecu.edu)
Preoperative chest CT examination showed that shape of the mediastinal tumor was regular, boundary was clear, and maximum diameter of the mass was less than 4 cm. (clinicaltrials.gov)
This book discusses the main approaches for mediastinal mass diagnosis and treatment, whose different aspects have been thoroughly treated by a multidisciplinary team of experts from different clinical fields. (springer.com)
A large anterior mediastinal mass (white arrows) is seen on this contrast-enhanced CT of the chest. (learningradiology.com)
PA and lateral chest films are the first step in distinguishing from which mediastinal compartment the mass is arising from. (virtualpediatrichospital.org)
The initial evaluation of a patient with a mediastinal mass includes a thorough history and physical examination. (clinicaladvisor.com)
The diagnosis of a mediastinal germ cell tumor should be considered in all young males with a mediastinal mass. (wikipedia.org)
citation needed] Second most common primary anterior mediastinal mass in adults. (wikipedia.org)

Although thymomas account for about 20% of mediastinal neoplasms and are the most-common anterior mediastinal neoplasm , (1) the overall incidence of thymomas is rare. (thefreedictionary.com)

Pure mediastinal seminomas are curable in the large majority of patients, even when metastatic at the time of diagnosis. (wikipedia.org)

Anatomy1

Organisms1

Diseases61

Chemicals and Drugs7

Analytical, Diagnostic and Therapeutic Techniques and Equipment3

Disciplines and Occupations1

Geographicals1

Primary mediastinal large B-cell lymphoma: a clinicopathologic study of 43 patients from the Nebraska Lymphoma Study Group. (1/673)

Neuromyotonia: an unusual presentation of intrathoracic malignancy. (2/673)

Diagnostic value of endoscopic ultrasonography-guided fine-needle aspiration cytology of mediastinal masses in patients with intrapulmonary lesions and nondiagnostic bronchoscopy. (3/673)

Primary mediastinal malignancies: findings in 219 patients. (4/673)

Thymic carcinoma of the thymic hormone secretory type in a cow. (5/673)

Core needle biopsy is effective in the initial diagnosis of mediastinal lymphoma. (6/673)

Diagnostic role of gallium scanning in the management of lymphoma with mediastinal involvement. (7/673)

Aggressive primary mediastinal non-Hodgkin's lymphomas: a study of 29 cases. (8/673)

No images available that match "mediastinal neoplasms"

Mediastinal Neoplasms

Pancreatic Neoplasms

Neoplasms

Neoplasms, Cystic, Mucinous, and Serous

Skin Neoplasms

Neoplasms, Multiple Primary

Kidney Neoplasms

Neoplasms, Second Primary

Adenocarcinoma, Mucinous

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Immunohistochemistry

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Neoplasm Staging

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Antigens, Neoplasm

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Mouth Neoplasms

Primary mediastinal large B-cell lymphoma: a clinicopathologic study of 43 patients from the Nebraska Lymphoma Study Group. (1/673)

Neuromyotonia: an unusual presentation of intrathoracic malignancy. (2/673)

Diagnostic value of endoscopic ultrasonography-guided fine-needle aspiration cytology of mediastinal masses in patients with intrapulmonary lesions and nondiagnostic bronchoscopy. (3/673)

Primary mediastinal malignancies: findings in 219 patients. (4/673)

Thymic carcinoma of the thymic hormone secretory type in a cow. (5/673)

Core needle biopsy is effective in the initial diagnosis of mediastinal lymphoma. (6/673)

Diagnostic role of gallium scanning in the management of lymphoma with mediastinal involvement. (7/673)

$The FDA has approved Keytruda For the Treatment of Refractory Primary Mediastinal Large B-cell Lymphoma - Patient Worthy$ The FDA has approved Keytruda For the Treatment of Refractory Primary Mediastinal Large B-cell Lymphoma - Patient Worthy