Tumors or cancer of the MEDIASTINUM.
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Neoplasms containing cyst-like formations or producing mucin or serum.
Tumors or cancer of the SKIN.
Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.
Tumors or cancers of the KIDNEY.
Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.
An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)
Tumors or cancer of the THYROID GLAND.
Conditions which cause proliferation of hemopoietically active tissue or of tissue which has embryonic hemopoietic potential. They all involve dysregulation of multipotent MYELOID PROGENITOR CELLS, most often caused by a mutation in the JAK2 PROTEIN TYROSINE KINASE.
DNA present in neoplastic tissue.
Tumors or cancer of the LUNG.
Tumors or cancer of the PAROTID GLAND.
A benign neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. In some instances, considerable portions of the neoplasm, or even the entire mass, may be cystic. (Stedman, 25th ed)
Neoplasms developing from some structure of the connective and subcutaneous tissue. The concept does not refer to neoplasms located in connective or soft tissue.
Neoplasms associated with a proliferation of a single clone of PLASMA CELLS and characterized by the secretion of PARAPROTEINS.
Tumors or cancer of the APPENDIX.
Tumors or cancer of the LIVER.
A multilocular tumor with mucin secreting epithelium. They are most often found in the ovary, but are also found in the pancreas, appendix, and rarely, retroperitoneal and in the urinary bladder. They are considered to have low-grade malignant potential.
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.
Tumors or cancer of the ENDOCRINE GLANDS.
Tumors or cancer of the GASTROINTESTINAL TRACT, from the MOUTH to the ANAL CANAL.
Carcinoma that arises from the PANCREATIC DUCTS. It accounts for the majority of cancers derived from the PANCREAS.
Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.
Neoplasms composed of vascular tissue. This concept does not refer to neoplasms located in blood vessels.
Tumors or cancer of the EYE.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Tumors or cancer of the NOSE.
Tumors or cancer of the SALIVARY GLANDS.
Tumors, cancer or other neoplasms produced by exposure to ionizing or non-ionizing radiation.
An adenocarcinoma containing finger-like processes of vascular connective tissue covered by neoplastic epithelium, projecting into cysts or the cavity of glands or follicles. It occurs most frequently in the ovary and thyroid gland. (Stedman, 25th ed)
A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (Stedman, 25th ed)
Tumors or cancer of the TESTIS. Germ cell tumors (GERMINOMA) of the testis constitute 95% of all testicular neoplasms.
Neoplasms composed of muscle tissue: skeletal, cardiac, or smooth. The concept does not refer to neoplasms located in muscles.
Neoplasms composed of glandular tissue, an aggregation of epithelial cells that elaborate secretions, and of any type of epithelium itself. The concept does not refer to neoplasms located in the various glands or in epithelial tissue.
A malignant cystic or semisolid tumor most often occurring in the ovary. Rarely, one is solid. This tumor may develop from a mucinous cystadenoma, or it may be malignant at the onset. The cysts are lined with tall columnar epithelial cells; in others, the epithelium consists of many layers of cells that have lost normal structure entirely. In the more undifferentiated tumors, one may see sheets and nests of tumor cells that have very little resemblance to the parent structure. (Hughes, Obstetric-Gynecologic Terminology, 1972, p184)
A benign epithelial tumor with a glandular organization.
Neoplasms of whatever cell type or origin, occurring in the extraskeletal connective tissue framework of the body including the organs of locomotion and their various component structures, such as nerves, blood vessels, lymphatics, etc.
Neoplasms located in the blood and blood-forming tissue (the bone marrow and lymphatic tissue). The commonest forms are the various types of LEUKEMIA, of LYMPHOMA, and of the progressive, life-threatening forms of the MYELODYSPLASTIC SYNDROMES.
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
Tumors or cancer of the UTERUS.
Tumors or cancer of the INTESTINES.
Neoplasms composed of sebaceous or sweat gland tissue or tissue of other skin appendages. The concept does not refer to neoplasms located in the sebaceous or sweat glands or in the other skin appendages.
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
Neoplasms located in the vasculature system, such as ARTERIES and VEINS. They are differentiated from neoplasms of vascular tissue (NEOPLASMS, VASCULAR TISSUE), such as ANGIOFIBROMA or HEMANGIOMA.
A general term for various neoplastic diseases of the lymphoid tissue.
Tumors or cancer located in bone tissue or specific BONES.
Tumors or cancer of the PALATE, including those of the hard palate, soft palate and UVULA.
Neoplasms composed of more than one type of neoplastic tissue.
Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.
Tumors or cancer of the MANDIBLE.
A malignant neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. The neoplastic cells manifest varying degrees of anaplasia and invasiveness, and local extension and metastases occur. Cystadenocarcinomas develop frequently in the ovaries, where pseudomucinous and serous types are recognized. (Stedman, 25th ed)
Tumors or cancer of the BILE DUCTS.
Ability of neoplasms to infiltrate and actively destroy surrounding tissue.
Tumors or cancer of the THYMUS GLAND.
Tumors or cancer of the SPLEEN.
Tumors in any part of the heart. They include primary cardiac tumors and metastatic tumors to the heart. Their interference with normal cardiac functions can cause a wide variety of symptoms including HEART FAILURE; CARDIAC ARRHYTHMIAS; or EMBOLISM.
A cystic tumor of the ovary, containing thin, clear, yellow serous fluid and varying amounts of solid tissue, with a malignant potential several times greater than that of mucinous cystadenoma (CYSTADENOMA, MUCINOUS). It can be unilocular, parvilocular, or multilocular. It is often bilateral and papillary. The cysts may vary greatly in size. (Dorland, 27th ed; from Hughes, Obstetric-Gynecologic Terminology, 1972)
Tumors or cancer of the COLON.
Cancer or tumors of the MAXILLA or upper jaw.
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
Diseases of the domestic dog (Canis familiaris). This term does not include diseases of wild dogs, WOLVES; FOXES; and other Canidae for which the heading CARNIVORA is used.
Tumors or cancer of the anal gland.
Neoplasms composed of primordial GERM CELLS of embryonic GONADS or of elements of the germ layers of the EMBRYO, MAMMALIAN. The concept does not refer to neoplasms located in the gonads or present in an embryo or FETUS.
Neoplasms located in the bone marrow. They are differentiated from neoplasms composed of bone marrow cells, such as MULTIPLE MYELOMA. Most bone marrow neoplasms are metastatic.
Neoplasms composed of fatty tissue or connective tissue made up of fat cells in a meshwork of areolar tissue. The concept does not refer to neoplasms located in adipose tissue.
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
Benign and malignant neoplastic processes that arise from or secondarily involve the meningeal coverings of the brain and spinal cord.
Tumors or cancer of the DUODENUM.
Tumors or cancers of the ADRENAL CORTEX.
Tumors or cancer of the MOUTH.

Primary mediastinal large B-cell lymphoma: a clinicopathologic study of 43 patients from the Nebraska Lymphoma Study Group. (1/673)

PURPOSE: To investigate whether primary mediastinal large B-cell lymphoma (PMLBL) is a distinct clinicopathologic entity with a more aggressive course than other diffuse large B-cell lymphomas (DLBL). MATERIALS AND METHODS: All patients with CD20-positive DLBL who presented with a mediastinal mass measuring at least 5.0 cm and were treated with curative intent were identified. A control group of 352 patients with nonmediastinal DLBL was selected for comparison. RESULTS: The 43 patients with PMLBL had a male to female ratio of 20:23 and a median age of 42 years. Stage I/II disease was present in 58% of the patients, with only 9% having bone marrow involvement. A complete remission was achieved in 63% of the patients, and the 5-year overall and failure-free survivals were 46% and 38%, respectively. Among the clinical variables, an elevated serum lactate dehydrogenase level, a low performance score, more than one extranodal site, and an intermediate or high International Prognostic Index score were predictive of poor survival. When compared with the DLBL group, a younger median age was the only clinical feature that was significantly different in the PMLBL group. CONCLUSION: The clinical features of PMLBL do not appear to be significantly different from those of nonmediastinal DLBL. Although the younger age of onset, slight female predominance, mediastinal location, and size of the mass may justify the recognition of PMLBL as a clinical syndrome, additional evidence is needed to define it as a distinct disease entity.  (+info)

Neuromyotonia: an unusual presentation of intrathoracic malignancy. (2/673)

A 48 year old woman is described who presented with increasing muscular rigidity and who was found to have a mediastinal tumour. Electrophysiological studies revealed that the muscular stiffness resulted from very high frequency motor unit activity which outlasted voluntary effort, and which was abolished by nerve block. The abnormal activity may have arisen at the anterior horn cell level. Marked improvement followed the administration of diphenylhydantoin.  (+info)

Diagnostic value of endoscopic ultrasonography-guided fine-needle aspiration cytology of mediastinal masses in patients with intrapulmonary lesions and nondiagnostic bronchoscopy. (3/673)

Several procedures are available for the cytopathological diagnosis of mediastinal lesions. The purpose of this study was to evaluate the diagnostic value of endoscopic ultrasonography (EUS)-guided fine-needle aspiration (FNA) in patients with mediastinal mass lesions/lymph node enlargement. All patients had intrapulmonary lesions on chest X ray and/or CT scan, and inconclusive findings by endobronchial forceps biopsy and/or brush cytology. EUS-guided FNA was performed in 16 patients using a modified oblique forward-viewing gastroscope with an electronic multielement curved linear ultrasound transducer. After the region of interest was localized, a 22-gauge Vilmann-Hancke needle was introduced via the 2-mm biopsy channel. The cytological diagnosis of EUS-guided FNA was conclusive for cancer in 9 patients and in the other 7 patients the aspirated samples revealed a benign lesion. In 10 patients the final diagnosis was cancer, thus EUS-guided FNA was diagnostic for malignancy in all but 1 of the lesions (sensitivity 90.0%). In 1 patient epitheloid cell granuloma was detected by cytological examination of the FNA. Following tuberculostatic treatment the lesions disappeared completely on CT scan and EUS. The overall accuracy in this study amounted to 93.7%. From this and other studies discussed, it is assumed that the procedure is an accurate and safe technique to examine nodular lesions suggestive of metastatic lymph node involvement.  (+info)

Primary mediastinal malignancies: findings in 219 patients. (4/673)

The purpose of this study was to determine the demographics, histology, methods of treatment, and survival in primary mediastinal malignancies. We did a retrospective review of the statewide New Mexico Tumor Registry for all malignant tumors treated between January 1, 1973 and December 31, 1995. Benign tumors and cysts of the mediastinum were excluded. Two hundred nineteen patients were identified from a total of 110,284 patients with primary malignancies: 55% of tumors were lymphomas, 16% malignant germ cell tumors, 14% malignant thymomas, 5% sarcomas, 3% malignant neurogenic tumors, and 7% other tumors. There were significant differences in gender between histologies (P < 0.001). Ninety-four percent of germ cell tumors occurred in males, 66% of neurogenic tumors were in females; other tumors occurred in males in 58% of cases. There were also significant differences in ages by histology (P < 0.001). Neurogenic tumors were most common in the first decade, lymphomas and germ cell tumors in the second to fourth decades, and lymphomas and thymomas in patients in their fifth decades and beyond. Stage at presentation (P = 0.001) and treatment (P < 0.001) also differed significantly between histologic groups. Five-year survival was 54% for lymphomas, 51% for malignant germ cell tumors, 49% for malignant thymomas, 33% for sarcomas, 56% for neurogenic tumors, and 51% overall. These survival rates were not statistically different (P > 0.50). Lymphomas, malignant germ cell tumors, and thymomas were the most frequently encountered malignant primary mediastinal neoplasms in this contemporary series of patients. Demographics, stage at presentation, and treatment modality varied significantly by histology. Despite these differences, overall five-year survival was not statistically different.  (+info)

Thymic carcinoma of the thymic hormone secretory type in a cow. (5/673)

An 8-year-old Holstein cow had tumor nodules and enlarged lymph nodes in the mediastinum, and metastatic tumor masses in the pelvic cavity. The neoplastic cells were characterized by squamous features and intracytoplasmic vacuoles carrying microvilli, some of which contained periodic acid Schiff-positive globular cores, but tubular structures or goblet cells were absent. Many neoplastic cells stained positively for keratin, and occasional cells were positive for thymosin. The presence of secretory granules in the cytoplasm was confirmed by electron microscopy. This neoplasm was considered to be of thymic hormone-secreting epithelial cell origin.  (+info)

Core needle biopsy is effective in the initial diagnosis of mediastinal lymphoma. (6/673)

BACKGROUND AND OBJECTIVE: With the development and refinement of guidance modalities for percutaneous biopsies, many investigators have reported studies supporting the role of guided core needle biopsy in the diagnosis of mediastinal lymphoma. The aims of this report are to evaluate the efficacy of findings at core needle biopsy of mediastinal masses on patient care and define the key determinants of clinical success. DESIGN AND METHODS: Fluoroscopy-guided (in 75 patients) and computed tomography-guided (in 8 patients) core needle biopsies were performed in 83 patients with mediastinal lymphoma: all but one of the patients were at first diagnosis. All the biopsies were performed using a Menghini needle (from 1.2 mm to 1.8 mm). In the vast majority of cases the 1.8 mm gauge was employed. RESULTS: The overall sensitivity for the diagnosis of lymphoma was 81% (67/83 cases). In the remaining 16 patients the lymphoma diagnosis was reached either by mediastinoscopy (11 cases) or anterior mediastinotomy (3 cases) or core needle biopsy of the lung (1 case); one patient was treated directly after the needle biopsy had been unsuccessful because he needed rapid therapy. In 77/82 (93%) patients it was possible to assess the specific histotype. There was no operative mortality; all the biopsies were performed on an outpatient basis. INTERPRETATION AND CONCLUSIONS: Our data indicate that core needle biopsy should be considered as an effective and safe procedure in the diagnosis of patients with mediastinal lymphoma with the possibility of determining the tumor subtype and subsequent specific treatment.  (+info)

Diagnostic role of gallium scanning in the management of lymphoma with mediastinal involvement. (7/673)

BACKGROUND AND OBJECTIVE: Therapy of both Hodgkin's disease (HD) and aggressive non-Hodgkin's lymphoma (NHL) with mediastinal presentation at the time of diagnosis is frequently followed by radiological detection of residual masses. Computed tomography (CT) scanning is generally unable to detect the differences between tumor tissue and fibrosis. Gallium-67-citrate single photon emission ((67)GaSPECT) can potentially differentiate residual active tumor tissue from fibrosis. DESIGN AND METHODS: Seventy-five patients with HD or aggressive NHL presenting mediastinal involvement (64% with a bulky mass) were studied with CT and (67)GaSPECT at the end of combined modality therapy (chemo- and radiation therapy). RESULTS: After treatment, 3/3 (100%) patients with positive (67)GaSPECT and negative CT scan relapsed while only 1/18 (6%) patients with both negative (67)GaSPECT and CT scan did so. At the same time, 54 patients had a positive restaging CT scan (abnormal mass < 10% of size of initial mass). Of these patients, 13 had a positive (67)GaSPECT, 10 of whom (77%) relapsed; 41 had a negative (67)GaSPECT of whom 5 (12%) relapsed. The 4-year actuarial relapse-free survival rate was 90% for those with negative scans compared with 23% for gallium-positive patients (p < 0.000000). INTERPRETATION AND CONCLUSIONS: In lymphoma patients with mediastinal involvement, (67)GaSPECT should be considered, at least in patients who are CT positive, the imaging technique of choice for monitoring and differentiating the nature of any residual masses.  (+info)

Aggressive primary mediastinal non-Hodgkin's lymphomas: a study of 29 cases. (8/673)

Aggressive primary mediastinal non-Hodgkin's lymphomas (NHL) represent a particular entity among intrathoracic neoplasms. Twenty-nine patients with primary mediastinal aggressive NHL diagnosed and treated in the author's institution were studied. According to the Revised European-American Lymphoma (REAL) classification, there were 15 diffuse large B-cell, eight T-lymphoblastic, four anaplastic, one large T-cell and one Burkitt's lymphomas. The study group consisted of 14 females and 15 males, with a mean age of 38 yrs. Symptoms arose from an aggressive anterior mediastinal mass, with a high prevalence of superior vena caval syndrome, pleural, and pericardial effusions. At the time of diagnosis, disease was confined to supradiaphragmatic areas in 24 patients, while subdiaphragmatic nodal or extranodal involvement was also present in five. All patients received a combination of aggressive chemotherapy regimens, mainly according to the French protocols for the treatment of NHL. A chest radiograph response of <50% after the first course of chemotherapy and failure to achieve a complete remission after the first line of chemotherapy were significantly associated with unfavourable prognosis. Overall 5-yr and 9-yr survival rates were 55 and 48%, respectively. Patients properly diagnosed and treated with a combined modality of chemotherapy can experience prolonged survival.  (+info)

Primary mediastinal B-cell lymphoma (PMBL) is characterized by aberrant activation of JAK/STAT-signaling resulting in constitutive presence of phosphorylated STAT6 (pSTAT6). identified five STAT-binding-sites in the promoter. We confirmed STAT6 binding to the promoter and by band shift / super shift assays and chromatin immunoprecipitationsUsing luciferase reporter assays, depletion of STAT6 by siRNA, and ectopic overexpression of a constitutive active STAT6 mutant, we proved that pSTAT6 is sufficient to transcriptionally KLF5 repress BCL6. Recently developed small molecule inhibitors 79-6 and TG101348 that increases BCL6 target gene expression and decreases pSTAT6 levels, respectively, demonstrate that a combined targeting results in additive efficacy regarding their negative effect on cell viability. The delineated pSTAT6-mediated molecular repression mechanism links JAK/STAT to BCL6-signaling in PMBL and may carry therapeutic potential. amplifications that established PMBL as a genetically ...
The US Food and Drug Administration has​ approved the medicine Keytruda for the treatment of Primary mediastinal large B-cell lymphoma (PMBCL).
Primary Mediastinal B-Cell Lymphoma (or PMBCL for short), is a very rare form of cancer. At this point, I think I have found and read every article or scientific study written about PMBCL. There are not that many in fact, as it was only designated as its own entity in 2008 (prior to this it…
First-line therapy in Primary Mediastinal Large B-Cell Lymphoma: first generation compared to third generation chemotherapy, and the increase in efficacy due to rituximab
A rare form of cancer, mediastinal germ cell tumour can be effectively treated with chemotherapy treatment, surgery and radiation therapy. The type of treatment of mediastinal germ cell tumour depends on certain factors.
Latest Mediastinal germ cell tumor News, Photos, Blogposts, Videos and Wallpapers. Explore Mediastinal germ cell tumor profile at Times of India
A dose-adjusted, infusion approach to aggressive chemotherapy with Rituxan® (rituximab) may allow patients with primary mediastinal B-cell lymphoma to skip radiation, according to the results of a study published in the New England Journal of Medicine.. Non-Hodgkins lymphoma (NHL) refers to a group of cancers that originate in different cells of the immune system. Diffuse large B-cell NHL (DLBCL) is a common type of NHL that affects immune cells called B-cells; it is considered an aggressive type of NHL. Primary mediastinal B-cell lymphoma is a distinct subtype of DLBCL that is closely related to nodular sclerosing Hodgkins lymphoma. Patients are usually young and present with large mediastinal masses. There is no standard treatment-and because immunochemotherapy alone has proven inadequate, some patients are treated with consolodiation with radiation, which has potentially serious late effects.. In an attempt to improve cure rates and prevent the need for radiation in this population, ...
TY - JOUR. T1 - CT of posterior mediastinal masses.. AU - Kawashima, Akira. AU - Fishman, E. K.. AU - Kuhlman, J. E.. AU - Nixon, M. S.. PY - 1991/1/1. Y1 - 1991/1/1. N2 - This article presents an algorithmic approach to the evaluation of posterior mediastinal masses seen with computed tomography (CT). CT remains the study of choice, since it not only can be used to help confirm the presence of these masses, but it also helps define the (a) location and extent of the lesion, (b) adjacent organ involvement, or (c) vascular involvement. Causes of posterior mediastinal masses include esophageal lesions, congenital or acquired vascular lesions, foregut cysts, intrathoracic goiters, mediastinal pseudocysts, fat-containing tumors, adenopathy, neurogenic tumors, infectious spondylitis, and vertebral tumors. From the CT appearance of the lesion, one can often distinguish among the various masses and identify their origin and cause. This information enables patient triage and therapy to be expedited and, ...
While NFKBIE deletions were relatively rare in patients diagnosed with follicular lymphoma (3/225 [1.3%]), splenic marginal zone lymphoma (3/175 [1.7%]), and T-cell acute lymphoblastic leukemia (1/94 [1.1%]), slightly higher frequencies were detected among DLBCL (18/520 [3.5%]), mantle cell lymphoma (8/189 [4.2%]), primary central nervous system lymphoma (1/34 [2.9%]), and small lymphocytic lymphoma (1/9 [11.1%]). In contrast, PMBL patients showed a marked enrichment, with 46 of 203 cases harboring a NFKBIE deletion (22.7% vs 2.9% [38/1257 in other entities]; P , .001; Figure 1A). Notably, the prevalence of NFKBIE-deleted PMBL cases was independent of contributing center (supplemental Table 3).. In an ongoing exome sequencing analysis of microdissected HRS cells in cHL, we obtained indication for NFKBIE mutations in 4 out of 11 cases. From these 4 cases, we isolated HRS cells and confirmed somatic NFKBIE aberrations (1 deletion and 2 missense mutations) in 3 out of 4 cases by Sanger sequencing ...
Physician assistants and nurse practitioners use Clinical Advisor for updated medical guidance to diagnose and treat common medical conditions in daily practice.
A free diabetes, endocrinology and medical news article resource for endocrinologists and physicians. Endocrinology conference coverage and drug information.
Yogi Berra offered the comment Its déjà vu all over again when he witnessed Mickey Mantle and Roger Maris repeatedly hitting back-to-back home runs in the early 1960s. His pithy remark neatly summarizes my reaction when I read the article, Dose-Adjusted EPOCH-Rituximab Therapy in Primary Mediastinal B-Cell Lymphoma, by Drs. Dunleavy, Wilson, and colleagues in The New England Journal of Medicine.1. The report nicely caps more than a decade of clinical investigation carried out by Dr. Wilsons group at the National Cancer Institute, focused on the use of infusional immunochemotherapy to treat various aggressive non-Hodgkin lymphomas (see a summary of the report in this issue of The ASCO Post). Briefly, this group demonstrated that when they used dose-adjusted EPOCH-R (etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin, and rituximab [Rituxan]) to treat primary mediastinal large B-cell lymphoma in 51 patients, almost all of the patients appeared to have been cured. ...
Diffuse large B cell lymphoma (DLBCL) is the most common histologic subtype of non-Hodgkin lymphoma (NHL), accounting for approximately 25 percent of adult NHL cases. (See.)The molecular pathogenesis of DLBCL is a complex, multistep process that ulti
The management of diffuse large B-cell lymphoma (DLBCL) has been gradually evolving since the discovery of its 2 major forms, the germinal center B-like (GCB) and activated B-cell (ABC) types. Although the reference standard for the identification of these cell types is considered gene expression profiling (GEP), currently the only method commercially available is immunohistochemistry (IHC). The application of various IHC-based algorithms and their correlation with GEP and clinical outcome are discussed. Because of the adverse prognostic implications of the non-GCB type and its potential effects on treatment selection, the recently revised World Health Organization classification has included these biologic cell types ...
The present study retrospectively examined the diagnostic utility of adding positron emission tomography (PET) or magnetic resonance imaging (MRI) to computed tomography (CT) alone for preoperative diagnosis of anterior mediastinal tumors. A total of 104 consecutive patients who had undergone surgical resection of anterior mediastinal tumors were divided into two groups: Additional PET to another modality and no additional PET to another modality, and further subdivided into three groups: CT alone, additional MRI to CT and additional PET to CT. The sensitivity, specificity, and accuracy for diagnosing malignant tumors in each subgroup was calculated. Comparing the two groups, the diagnostic sensitivity was similar for additional PET (98.0%) and no additional PET (95.2%) groups; however, the specificity and accuracy for additional PET (75.0 and 92.2%, respectively) were significantly improved compared with no additional PET (31.6 and 65.0%, respectively). In the subgroup analysis, adding PET to ...
Massive hemoptysis is described in many disease processes. However, a mediastinal teratoma is rarely considered in a patient presenting with massive hemoptysis. Since a mediastinal teratoma has no specific symptoms, its definitive diagnosis is difficult before surgical intervention. Flexible bronchoscopy can be diagnostic in cases of a mediastinal teratoma with involvement of the bronchial tree. We report 2 cases of hemoptysis caused by mediastinal teratoma with bronchial communication. ...
Recently, copy number alteration (CNA) of 9p24.1 were demonstrated in 10% of diffuse large b-cell lymphoma (DLBCL), with gene expression and mutation profiles that were similar to those of primary mediastinal large B-cell lymphoma (PMBCL). However, their CNA-based profile and clinical impact still remain unclear. Multiplex ligation-dependent probe amplification were employed to investigate the prevalence of JAK2/PD-L2 amplification in DLBCL and their CNA-based pattern of driver genes. The clinical outcome and characteristics were also analyzed. Using unsupervised hierarchical clustering, a small group of DLBCL (10.5%, 8/76) was clustered together with PMBCL as Cluster_2, demonstrating amplification of JAK2 (100%,8/8) and PD-L2 (75.0%,6/8). This subgroups of DLBCL demonstrated significant higher expression of PD-L1 than those with MYD88 L265P mutation(p = 0.024). And they exhibited dismal OS and PFS as compared with DLBCL_others(p = 0.003 and 0.001, respectively), which is similar to DLBCL with MYD88
Kite Pharma has created engineered cell therapies that express either a chimeric antigen receptor (CAR) or an engineered T-cell receptor (TCR), based on the type of cancer.. The companys primary CAR T therapy candidate, axicabtagene ciloleucel (axi-cel), is expected to be the first available treatment for refractory aggressive non-Hodgkin lymphoma, including diffuse large B-cell lymphoma (DLBCL), transformed follicular lymphoma (TFL) and primary mediastinal B-cell lymphoma (PMBCL).. Kite Pharma president, chairman and CEO Dr Arie Belldegrun said: CAR T has the potential to become one of the most powerful anti-cancer agents for hematologic cancers.. Axicabtagene ciloleucel is currently under priority review by the US Food and Drug Administration (FDA).. A marketing authorisation application (MAA) has also been filed with the European Medicines Agency (EMA) for axi-cel for the treatment of relapsed / refractory DLBCL, TFL and PMBCL.. The approval in Europe is expected in 2018.. ...
FOSTER CITY, Calif. & SANTA MONICA, Calif.-(BUSINESS WIRE)-Kite, a Gilead Company, (Nasdaq: GILD) today announced that the U.S. Food and Drug Administration (FDA) has granted regular approval to Yescarta™ (axicabtagene ciloleucel), the first chimeric antigen receptor T cell (CAR T) therapy for the treatment of adult patients with relapsed or refractory large B-cell lymphoma after two or more lines of systemic therapy, including diffuse large B-cell lymphoma (DLBCL) not otherwise specified, primary mediastinal large B-cell lymphoma (PMBCL), high-grade B-cell lymphoma, and DLBCL arising from follicular lymphoma (transformed follicular lymphoma, or TFL). Yescarta is not indicated for the treatment of patients with primary central nervous system lymphoma.. CAR T therapy is a breakthrough in hematologic cancer treatment in which a patients own T cells are engineered to seek and destroy cancer cells. CAR T therapy is manufactured specifically for each individual patient.. The FDA approval of ...
Cazals-Hatem D, Lepage E, Brice P, et al. Primary mediastinal large B-cell lymphoma. A clinicopathologic study of 141 cases compared with 916 nonmediastinal large B-cell lymphomas, a GELA (Groupe dEtude des Lymphomes de lAdulte) study. Am J Surg Pathol. 1996;20: 877-888 ...
Posterior mediastinal mass in a black patient with back pain. Clinical trials partnership seeks to boost research in developing countries
TY - JOUR. T1 - Il linfoma primitivo del mediastino. T2 - Stato dellarte e prospettive terapeutiche. AU - Foppoli, Marco. AU - Citterio, Giovanni. AU - Donadoni, Giovanni. AU - Govi, Silvia. AU - Ferreri, Andrés J M. PY - 2013/5. Y1 - 2013/5. N2 - Within diffuse large B-cell lymphomas, the Primary Mediastinal Large B-Cell Lymphoma has to be considered as a separate and well-defined clinico-pathological entity. Its tendency to target young adults makes its social impact particularly significant; hence, the General Practitioner carries the responsibility for an early diagnosis. On the contrary, the extreme complexity of the available therapies makes a quick referral to specialized Clinical Centres of outmost importance, since this remains the best way to enrol as many patients as possible in therapeutic protocols. Nowadays, good clinical results and a favourable outcome are achievable, but some questions remain open. The role of radiotherapy still has to be clarified, both as a complete ...
Green MR, Monti S, Rodig SJ, Juszczynski P, Currie T, ODonnell E, Chapuy B,Takeyama K, Neuberg D, Golub TR, Kutok JL, Shipp MA. Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma. Blood. 2010 Jul 13. Bradner JE, Mak R,
Faris, JE, Ryan DP. Biomarker-Driven Therapy in the Neoadjuvant Treatment of Colorectal Liver Metastases. Curr Colorectal Cancer Rep 2012; 8(2):143-151. Faris JE, Ryan DP. Trees, forests, and other implications of a BRAF mutant gene signature in patients with BRAF wt disease. J Clin Oncol. 2012 Apr 20; 30(12):1255-7. Faris JE, Arnott J, et al. A phase 2 study of oral MKC-1. Invest New Drugs. 2012 Aug; 30(4):1614-20. Faris JE, Smith MR. Metabolic sequelae associated with ADT for prostate cancer. Curr Opin Endocrinol Diabetes Obes. 2010 Jun; 17(3):240-6. Faris JE, Michaelson MD. Targeted therapies: Sunitinib vs interferon-alpha in metastatic RCC. Nat Rev Clin Oncol. 2010 Jan; 7(1):7-8. Faris JE, LaCasce AS. Primary mediastinal large B-cell lymphoma. Clin Adv Hematol Oncol. 2009 Feb; 7(2):125-33. Faris JE, Moore AF, Daniels GH. Sunitinib-induced thyrotoxicosis due to destructive thyroiditis: a case report. Thyroid. 2007 Nov; 17(11):1147-9. ...
|p>The mediastinum is the most common site for extragonadal germ cell tumors. Imaging and lab monitoring are important components of care for patients with this
BACKGROUND: Germinal center-derived B cell lymphomas are tumors of the lymphoid tissues representing one of the most heterogeneous malignancies. Here we characterize the variety of transcriptomic … phenotypes of this disease based on 873 biopsy specimens collected in the German Cancer Aid MMML (Molecular Mechanisms in Malignant Lymphoma) consortium. They include diffuse large B cell lymphoma (DLBCL), follicular lymphoma (FL), Burkitts lymphoma, mixed FL/DLBCL lymphomas, primary mediastinal large B cell lymphoma, multiple myeloma, IRF4-rearranged large cell lymphoma, MYC-negative Burkitt-like lymphoma with chr. 11q aberration and mantle cell lymphoma. METHODS: We apply self-organizing map (SOM) machine learning to microarray-derived expression data to generate a holistic view on the transcriptome landscape of lymphomas, to describe the multidimensional nature of gene regulation and to pursue a modular view on co-expression. Expression data were complemented by pathological, genetic and ...
Introduction: Epidemiology, Mediastinal Anatomy, Mediastinal Masses.- Clinical Approach: Recommendations for the Clinicians.- Mediastinal Masses: Radiological Point of View.- Radiotherapy in Anterior Mediastinum Cancers.- Surgery: Reccomandations for Surgeons.- Diagnostic Histopathology Approach.- Thymic Tumors and Lymphomas: The Clinical Impact of their Underlying Molecular Features.- Therapy: Recommendations for the Oncologists.- Thymic Neoplasm.- Primitive Mediastinal Germ Cell Tumors: An Update.- Thyroid.- Parathyroid.- Mediastinal Lymphoma.- Granulomatous Disease.- Cysts of The Middle Mediastinum.- Tracheal Tumors.- Nerve Sheath Tumors, Ganglion Tumours and Neurenteric Cysts.- Esophageal Tumors. This is a well‐organized, visually appealing, relatively quick‐to‐read resource meant for a wide audience, including pathologists, oncologists, radiologists, and surgeons. … it does effectively communicate the necessary perspectives. I especially recommend this book for practicing ...
Background: Germinal center-derived B cell lymphomas are tumors of the lymphoid tissues representing one of the most heterogeneous malignancies. Here we characterize the variety of transcriptomic phenotypes of this disease based on 873 biopsy specimens collected in the German Cancer Aid MMML (Molecular Mechanisms in Malignant Lymphoma) consortium. They include diffuse large B cell lymphoma (DLBCL), follicular lymphoma (FL), Burkitts lymphoma, mixed FL/DLBCL lymphomas, primary mediastinal large B cell lymphoma, multiple myeloma, IRF4-rearranged large cell lymphoma, MYC-negative Burkitt-like lymphoma with chr. 11q aberration and mantle cell lymphoma. Methods: We apply self-organizing map (SOM) machine learning to microarray-derived expression data to generate a holistic view on the transcriptome landscape of lymphomas, to describe the multidimensional nature of gene regulation and to pursue a modular view on co-expression. Expression data were complemented by pathological, genetic and clinical ...
Background: Germinal center-derived B cell lymphomas are tumors of the lymphoid tissues representing one of the most heterogeneous malignancies. Here we characterize the variety of transcriptomic phenotypes of this disease based on 873 biopsy specimens collected in the German Cancer Aid MMML (Molecular Mechanisms in Malignant Lymphoma) consortium. They include diffuse large B cell lymphoma (DLBCL), follicular lymphoma (FL), Burkitts lymphoma, mixed FL/DLBCL lymphomas, primary mediastinal large B cell lymphoma, multiple myeloma, IRF4-rearranged large cell lymphoma, MYC-negative Burkitt-like lymphoma with chr. 11q aberration and mantle cell lymphoma. Methods: We apply self-organizing map (SOM) machine learning to microarray-derived expression data to generate a holistic view on the transcriptome landscape of lymphomas, to describe the multidimensional nature of gene regulation and to pursue a modular view on co-expression. Expression data were complemented by pathological, genetic and clinical ...
BACKGROUND: Germinal center-derived B cell lymphomas are tumors of the lymphoid tissues representing one of the most heterogeneous malignancies. Here we characterize the variety of transcriptomic … phenotypes of this disease based on 873 biopsy specimens collected in the German Cancer Aid MMML (Molecular Mechanisms in Malignant Lymphoma) consortium. They include diffuse large B cell lymphoma (DLBCL), follicular lymphoma (FL), Burkitts lymphoma, mixed FL/DLBCL lymphomas, primary mediastinal large B cell lymphoma, multiple myeloma, IRF4-rearranged large cell lymphoma, MYC-negative Burkitt-like lymphoma with chr. 11q aberration and mantle cell lymphoma. METHODS: We apply self-organizing map (SOM) machine learning to microarray-derived expression data to generate a holistic view on the transcriptome landscape of lymphomas, to describe the multidimensional nature of gene regulation and to pursue a modular view on co-expression. Expression data were complemented by pathological, genetic and ...
Chest x-ray in a child demonstrates a rounded mass projecting over the mediastinum. The descending aorta can clearly be seen through it suggesting the mass is anterior. CT confirms that the mass is in the anterior mediastinum. It is well circum...
Define mediastinal neoplasm. mediastinal neoplasm synonyms, mediastinal neoplasm pronunciation, mediastinal neoplasm translation, English dictionary definition of mediastinal neoplasm. n. pl. me·di·as·ti·na The region in mammals between the pleural sacs, containing the heart and all of the thoracic viscera except the lungs. me′di·as·ti′nal...
This 53-year old man with a history of persistent hemosputum was admitted for mitral valve surgery. At the age of 32 he was diagnosed with a..
Another pdf thoracic surgery transplantation tracheal resections mediastinal tumors extended thoracic resections between mobile and easy operations has that violent geophysics homework transfer pdf, where 1940s of one use Privacy their power or research of the presumed data. We would be source decision to like in directories with nothing and online actions always not as no explaining results. free notes are troubled Old patterns than unique data.
Mediastinal tumor | Resection of the tumor. Thoracic surgery: Treatment in Cologne, Germany ✈. Prices on BookingHealth.com - booking treatment online!
Mediastinal tumor | Resection of the tumor. Thoracic surgery: Treatment in Würzburg, Germany ✈. Prices on BookingHealth.com - booking treatment online!
Factors influencing the length of stay after mediastinal tumor resection in the setting of an enhanced recovery after surgery (ERAS)-TUBELESS protocol
Learn more about Mediastinal Tumor Resection at Medical City Plano DefinitionReasons for ProcedurePossible ComplicationsWhat to ExpectCall Your Doctorrevision ...
Mediastinal Tumors - RWJBarnabas Health is a leading provider of compassionate, quality, & cost-efficient medical care services in the state of New Jersey.
In October 2016, at the age of 21, I was diagnosed with primary mediastinal large B-cell non-Hodgkins lymphoma. After a few weeks of chest pains, finding a lump on my chest which led to many tests, I was admitted to Cincinnati Childrens Hospital where I received treatment.
Aims: Patients presenting with a neck mass are commonly seen by the ENT surgeon. They are also usually related to head and neck tumours. However, cervical node involvement from the prostate is rare, especially as an initial presentation of the disease. We report a case of prostate carcinoma presenting with a left supraclavicular lymph node.. Presentation of Case: A 61-year-old gentleman presented to our clinic with a rapidly growing left sided neck mass. Fine needle aspiration cytology (FNAC) of the neck mass was interpreted as metastatic carcinoma. It was later revealed by the patient that he had been experiencing lower urinary tract symptoms (LUTS). PSA was 1331 ng/ml. He was referred to our urology service and was treated as metastatic prostate cancer.. Discussion: Prostate cancer commonly spreads to the regional lymph nodes, pelvic organs, or the axial skeleton. Distant metastases to the cervical nodes are rare and accounts for 0.3-1% of cases.. Conclusion: In male patients presenting with ...
Mediastinum is a common localization of extra gonadal teratoma. Mediastinal teratoma, which is comprising of 1-5% of all mediastinal tumors is an in..
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
A multicentric study of lung cancer staged by PET-TC and EBUS-NA was performed to identify PET-TC measures with high positive predictive value (PPV) for the identification of stage III disease and to evaluate EBUS-NA sensitivity. A surgical gold standard was used when EBUS-NA was negative.. Results: 76/105 patients showed ≥1 hypermetabolic spot in mediastinum (72%). PET-TC SUVmax did not show statistically significant differences between centers. Lung SUVmax had mean of 11.4 (SD 5.3), and hypermetabolic spot in mediastinum median of 3.4 (IQR 0-6.5). EBUS-NA confirmed mediastinal metastasis in 43/54 patients (79.6%). A single hypermetabolic image in mediastinum was not a significant predictor of dissemination (OR 1.99 95%CI 0.75-5.32), but ≥2 hypermetabolic spots showed an increased risk (OR 3.64 95%CI 1.29-10.26). Lung SUVmax was not associated with mediastinal malignancy (OR 0.93 95%CI 0.86-1.01), but mediastinum SUVmax ,3.4 was a significant predictor (OR 6,36 95%CI 2,71-14,91), that ...
Neurogenic tumors are the most common cause of posterior mediastinal masses. Schwannomas and neurofibromas arise from peripheral nerves and are more common in
Mediastinal tumors can be developped in the mediastinum - the area of the chest that separates the lungs and contains the heart, aorta, esophagus, thymus, and trachea. Mediastinal tumors are treated by the Division of Thoracic Surgery at IEO.
BACKGROUND: Mediastinal and central large vessels (T4) invasion by lung cancer is often difficult to assess preoperatively due to the limited accuracy of computed tomography (CT) scan of the chest. Esophageal ultrasound (EUS) can visualize the relationship of para-esophageally located lung tumors to surrounding mediastinal structures. AIM: To assess the value of EUS for detecting mediastinal invasion (T4) of centrally located lung tumors. METHODS: Patients who underwent EUS for the diagnosis and staging of lung cancer and in whom the primary tumor was detected by EUS and who subsequently underwent surgical- pathological staging (2000-2016) were retrospectively selected from two university hospitals in The Netherlands ...
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. © 1997- A.D.A.M., a business unit of Ebix, Inc. Any duplication or distribution of the information contained herein is strictly prohibited ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
This study was designed as a single-center prospective randomized controlled trial. The trial recruited patients aged from 18 to 75 years with a diagnosis of mediastinal tumor. Preoperative chest CT examination showed that shape of the mediastinal tumor was regular, boundary was clear, and maximum diameter of the mass was less than 4 cm. Other inclusion criteria included capability of giving consent and adequate organ function to tolerate uniportal thoracoscopy mediastinal tumor resection. The exclusion criteria are described as follows: preoperative examination showed that the tumor invaded the surrounding blood vessels, pericardium, lung and other tissues or had distant metastasis; preoperative complications include severe coronary heart disease, arrhythmia and other serious cardiopulmonary diseases; large masses, difficult surgical procedures; manifestations of myasthenia gravis; hypovolemia, blood disorders, or abnormal clotting mechanism; pulmonary function and arterial blood gas analysis ...
TY - JOUR. T1 - The importance of the simple chest X-ray tend to make careless interpretation. T2 - With a case of mediastinal tumor. AU - Eun, Young Kim. AU - Ju, Eun Lim. AU - Byung, Hoon Park. AU - Jin, Young Yoon. AU - Ji, Ye Jung. AU - Ji, Young Son. AU - Kyung, Jong Lee. AU - Yoe, Wun Yoon. AU - Young, Ae Kang. AU - Jin, Wook Moon. AU - Moo, Suk Park. AU - Young, Sam Kim. AU - Chang, Joon. AU - Sung, Kwan Shin. AU - Se, Kyu Kim. PY - 2009/6. Y1 - 2009/6. N2 - The middle mediastinum contains several important organs and pluripotent cells. It is difficult to make a definitive diagnosis in patients with middle mediastinal tumors due to a wide range of diseases. The likelihood of malignancy is influenced primarily by the following factors: patient age, size, tumor location, and the presence or absence of symptoms. We describe a case of a middle mediastinal tumor, which was suspected on chest x-ray; chest computed tomography revealed the eccentric mass of distal esophagus. This case emphasizes ...
The MAL mRNA was initially identified during T-cell development and was later found in myelin-forming cells and certain polarized epithelial cell lines. It encodes a proteolipid believed to participate in membrane microdomains stabilization, transport machinery and signal transduction. Using a diffe …
MONDAY, Dec. 11, 2017 (HealthDay News) - Axicabtagene ciloleucel (axi-cel), an autologous anti-CD19 chimeric antigen receptor (CAR) T-cell therapy and autologous T cells that express a CD19-directed CAR (CTL019) are effective for refractory B-cell lymphomas, according to two studies published online Dec. 10 in the New England Journal of Medicine to coincide with the annual meeting of the American Society of Hematology, held from Dec. 9 to 12 in Atlanta.. Sattva S. Neelapu, M.D., from the University of Texas MD Anderson Cancer Center in Houston, and colleagues enrolled 111 patients with diffuse large B-cell lymphoma, primary mediastinal B-cell lymphoma, or transformed follicular lymphoma with refractory disease despite receiving prior therapy. A target dose of 2×106 anti-CD19 CAR T cells/kg body weight was administered to 101 patients. The researchers found that the objective and complete response rates were 82 and 54 percent, respectively. Overall, 42 percent of the patients continued to have a ...
Chimeric antigen receptor T-cells are a novel class of anti-cancer therapy in which autologous or allogeneic T-cells are engineered to express a chimeric antigen receptor targeting a membrane antigen. In Europe, Tisagenlecleucel (KymriahTM) is approved for the treatment of refractory/relapsed Acute Lymphoblastic Leukaemia in children and young adults as well as relapsed/refractory Diffuse Large B-cell Lymphoma; Axicabtagene ciloleucel (YescartaTM) is approved for the treatment of relapsed/refractory high-grade B-cell Lymphoma and Primary Mediastinal B-cell Lymphoma. Both agents are genetically engineered autologous T-cells targeting CD19. These practical recommendations, prepared under the auspices of the European Society of Blood and Marrow Transplantation, relate to patient care and supply chain management under the following headings: patient eligibility, screening laboratory tests and imaging and work-up prior to leukapheresis, how to perform leukapheresis, bridging therapy, lymphodepleting ...
Mediastinal lymphoma in dogs usually develops in the lymphoid tissues of the chest. They are present around the cardiothoracic region. If left untreated, they can restrict the function of lungs, resulting in death.. Symptoms- This form of lymphoma comprises only a fraction of all cases of lymphosarcomas. It is typically characterized by enlargement of the cranial mediastinal lymph nodes, thymus, or both. Dogs suffering from mediastinal lymphoma encounter respiratory distress, polydipsia, polyuria, pitting edema of the head, necks and forelimbs.. Cutaneous lymphoma- It originates in the skin and can take the form of reddened lumps that can be itchy at times and also cause extreme discomfiture in dogs.. Symptoms- They appear as ulcers, nodules, plaques, ulcers, and erythremic or exfoliative dermatitis. In the early phases scaling, alopecia (loss of hair), and pruritus (itching) are seen. As the disease advances the skin becomes more erythematous, thickened, ulcerated, and exudative (relating to ...
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
TY - JOUR. T1 - Computed tomographic evaluation of canine and feline mediastinal masses in 14 patients. AU - Yoon, Junghee. AU - Feeney, Daniel A. AU - Cronk, Daniel E.. AU - Anderson, Kari L. AU - Ziegler, Laura E.. PY - 2004/11/1. Y1 - 2004/11/1. N2 - A 15-year retrospective analysis of histologically proven canine and feline mediastinal malignancies at the University of Minnesota was conducted to identify patients imaged by computed tomography (CT). The goal of the study was to characterize the CT appearance, to determine if there were any tumor type-specific appearances, and to clarify the role of CT in patients with mediastinal masses. Fourteen patients meeting these criteria were available for evaluation. The masses were characterized based on the presence or absence of contrast enhancement, internal architecture, size, extent of local invasion, the presence of pleural fluid, and the presence of regional vascular invasion. Within the limits of this study and the histopathologic information ...
Available reports suggest that an anterior mediastinal mass causing more than 50% narrowing of the trachea and compressing the great vessels can cause further narrowing o..
The risk of life-threatening complications during induction of anesthesia in patients with anterior mediastinal mass is well recognized. Maintenance of spontaneous ventilation during anesthesia is an accepted standard goal in all published reports. However, the decision to paralyze the patient, which is really needed in most surgical procedures, is still a challenging event. In this study,
Getting a film with an anterior mediastinal mass in the exam is one of the many exam set-pieces that can be prepared for. The film goes up and after a couple of seconds pause, you need to start talking: CXR There is a left sided mediastinal ma...
The Gray-Zone Lymphomas represent histological entities that are interposed between Hodgkins lymphoma and Non-Hodgkins Lymphoma. We report the case of a man diagnosed with a Lymphoma B unclassifiable with intermediate characteristics between Hodgkins lymphoma and a large cell lymphoma B, with a rare spinal localization. We decided to treat him with Adriamycin, Bleomycin, Vinblastine, Dacarbazine and anti-CD20 antibody, achieving a complete response. We here discuss histopathologic patterns, and work-up of this pathological entity, and we demonstrated that more intensive therapy do not always correlate with better therapeutic goals, inviting to analyze each case.. ...
For patients with a possible mediastinal mass, the first step is to obtain a chest radiograph. Following the chest radiograph, a CT can help to further delineate the features of the tumor. Additional workup could include: echocardiogram and pulmonary function tests [1,3,4]. Ultimately, tissue diagnosis will be necessary. There is no ideal anesthetic technique for a patient with AMM, as any technique can be associated with morbidity and mortality. However, the overall anesthetic goals should include: maintenance of spontaneous ventilation, coordination of appropriate equipment for airway and cardiac support, and ensuring availability of emergency team members [2]. Based on the presence or absence of respiratory symptoms, degree of tracheal compression, mediastinal mass ratio and other factors, patients may be classified as being at high or low risk (Figure 3). A low risk patient, who does not have any respiratory symptoms or tracheal compression by CT, may proceed with a general anesthetic. ...
The posterior mediastinum is the portion of the mediastinum located posteriorly to the pericardium and anteriorly to the T5-T12 vertebrae, inferior to the transverse thoracic plane. This article will consider the borders and contents of this anatomical compartment.
Definition of Mediastinal diseases with photos and pictures, translations, sample usage, and additional links for more information.
The anterior mediastinum is the portion of the mediastinum anterior to the pericardium and below the thoracic plane. It forms the anterior part of the inferior mediastinum, and contains the thymus, lymph nodes, and may contain the portions of a ...
Seminomas are unusual primary tumors of the anterior mediastinum. Morphologically, they are indistinguishable from their testicular counterparts; however, in the mediastinum, the occurrence of seconda
Germ cell tumors of the mediastinum are uncommon. Less than 5-7% of germ cells occur outside the gonads, but of the extragonadal sites, the mediastinum is the most common location for germ cell tumors.
Hi…this is my first time to participate in your intesting blog,…and here is what i see:. The right lower lung zone show relatively well defined radiopacity seen with well defined upper border and showing negative silhuoette sign with the right cardiac border, also it is seen at the lateral film projected over the right loer lung zone and with well defined anterior superior border and with relatively obtuse angle with the plueral surface (extra pulmonary) and seprable from the hemidiaphragm….so it is wither of plueral origin ( answer 2) or a posterior mediastinal mass ( may be of spinal) or posterior chest wall ...
TY - JOUR. T1 - How to prevent and manage radiation-induced coronary artery disease. AU - Cuomo, Jason R.. AU - Javaheri, Sean P.. AU - Sharma, Gyanendra K.. AU - Kapoor, Deepak. AU - Berman, Adam E.. AU - Weintraub, Neal L.. PY - 2018/10/1. Y1 - 2018/10/1. N2 - Radiation-induced coronary heart disease (RICHD) is the second most common cause of morbidity and mortality in patients treated with radiotherapy for breast cancer, Hodgkins lymphoma and other prevalent mediastinal malignancies. The risk of RICHD increases with radiation dose. Exposed patients may present decades after treatment with manifestations ranging from asymptomatic myocardial perfusion defects to ostial, triple-vessel disease and sudden cardiac death. RICHD is insidious, with a long latency and a tendency to remain silent late into the disease course. Vessel involvement is often diffuse and is preferentially proximal. The pathophysiology is similar to that of accelerated atherosclerosis, characterised by the formation of ...
Chest x-ray shows a large lobulated anterior mediastinal mass (asterisks). Because the mass does not obscure the shadow of the aortic know and descending aorta
Mediastinal Irradiation (Irradiation of Mediastinum): Read more about Symptoms, Diagnosis, Treatment, Complications, Causes and Prognosis.
A 17-year-old female was recently diagnosed with Hodgkins disease based on a biopsy of a new neck mass. She is scheduled for insertion of a permanent indwelling central venous catheter to facilitate administration of chemotherapy. Is there anything else you would like to know prior to proceeding with administration of general anesthesia? Patients with newly…
Choose articles related to Mediastinal Masses Radiology, search nearby doctors or look up health related Q&A by the doctors | Practo
Journal of clinical medicine, 7(6), 25. Babies cannot response independently to the burr holes are connected to a home health team to bring a mediastinal mass or other substances in the orbit, the apex of the surgical defect. 5. Inspection of external fixation orthopedic surgery pose no risk of anaphylaxis. Assess disorders of the mouth to reduce the risk of becoming affected by arthritis result in a lymph node or a pulsating mass and obstruction is localized, often with exten- sion of the. Explain the need to be concerned about body image related to complications. 1620/s6-312x2008000600056. Associated with improved bone density values in healthy children and adolescents is affected, initiate strategies to avoid tick exposure in the bladder may be first indication. Whereas c. Jejuni as compared to cell type: Nonsmall cell lung cancer shows characteristics of the computed tomography scan; magnetic resonance imaging scan shows that the superior mediastinum presenting at the current era: Early ...
Teratoma: Operative Findings, Preparation (Tumor Anterior Mediastinum). metu_10a_n.jpg and metu_10b_n.jpg: Operative findings and preparation of an inhomogeneous mass in the anterior mediastinum of a 5.8-year-old girl. In the midline medially of the left lung a large and polymorphic mass is visible which contains at the bottom a grey and homogeneous part and at the top a yellowish and inhomogeneous part. It is recognizable even more distinctly in the preparation; some of the reddish elements are vessels. Notice the length of the mass of 16 to 17 cm. The diagnosis is an adult differentiated teratoma. ...
▪ Mediastinal Lesions Although it may not be difficult to identify a mediastinal mass on cross-sectional imaging, it can be challenging to determine its nature. Diagnostic specificity is critical to prevent unnecessary intervention and its associated morbidity and expenditure. The aim of this chapter is to serve as a guide toward maximizing the benefit of…
Mediastinum Definition The mediastinum is an undefined anatomic space between the lungs that comprises a group of structures within the thorax and principal
Psychiatry healthcare professionals gain a thorough knowledge base of psychiatric disorder information to offer the best patient care. Get our FREE app now.
Mediastinum anterius information including symptoms, causes, diseases, symptoms, treatments, and other medical and health issues.
ICD-10-PCS code 0WWC0JZ for Revision of Synthetic Substitute in Mediastinum, Open Approach is a medical classification as listed by WHO under the rang
Mediastinum aims to provide high level evidence and useful resources for all healthcare professionals engaged in delivering quality care to their mediastinal patients.
Mediastinum aims to provide high level evidence and useful resources for all healthcare professionals engaged in delivering quality care to their mediastinal patients.
Keywords: extra-adrenal paraganglioma, mediastinal neoplasms, metanephrine. Contact Information. [email protected] ... Posterior mediastinal paraganglioma: the experience of Kasr Alainy Thoracic Surgery Unit. Waleed Adel1, Tarek Mohsen1, Ramadan ... Background: Mediastinal paragangliomas are rare tumors with variable clinical presentations and combinations. Having such ... Methods: During seven years, from January 2012 until November 2019, data of eight patients who underwent posterior mediastinal ...
We herein report a case of mediastinal tuberculosis with unusual manifestations.. AB - Mediastinal tuberculous lymphadenitis is ... and it is even rarer for dysphagia to be the presenting symptom of mediastinal tuberculous lymphadenitis. Mediastinal ... and it is even rarer for dysphagia to be the presenting symptom of mediastinal tuberculous lymphadenitis. Mediastinal ... and it is even rarer for dysphagia to be the presenting symptom of mediastinal tuberculous lymphadenitis. Mediastinal ...
A 57-year-old man was pointed out the anterior mediastinal tumor when his generator of pacemaker was exchanged. The tumor was ... A 57-year-old man was pointed out the anterior mediastinal tumor when his generator of pacemaker was exchanged. The tumor was ... A 57-year-old man was pointed out the anterior mediastinal tumor when his generator of pacemaker was exchanged. The tumor was ... A 57-year-old man was pointed out the anterior mediastinal tumor when his generator of pacemaker was exchanged. The tumor was ...
What are pulmonary carcinoid tumors? These are rare neuroendocrine neoplasms that range from low-grade typical… ... What are neurogenic tumors? Neurogenic tumors are the most common cause of posterior mediastinal masses.… ...
  • Dr Roden focuses her research on mediastinal neoplasms , lung tumors, malignant mesotheliomas, tumor biomarkers, and nonneoplastic lung diseases, including lung allograft pathology. (thefreedictionary.com)
  • TNT Uniportal Video-assisted Thoracoscopic Surgery (VATS) has become popular during mediastinal tumors resection. (clinicaltrials.gov)
  • The aim of our RCT was to evaluate the feasibility and advantage of TNT Uniportal VATS for mediastinal tumors resection and its significance in Fast Track Surgery (FTS). (clinicaltrials.gov)
  • 98 patients aged between 18 and 75 years with clinically mediastinal tumors were randomly assigned to two groups, 50 patients received TNT uniportal VATS mediastinal tumor resection (TNT group) and 48 patients underwent traditional uniportal VATS mediastinal tumor resection (control group), the short-term perioperative outcomes would be reported here. (clinicaltrials.gov)
  • The term mediastinal gray zone lymphoma (MGZL) has been used for these tumors, which are included in the World Health Organization classification as "B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classic Hodgkin lymphoma. (nih.gov)
  • Among T-cell neoplasms, MAL was highly expressed in lymphoblastic tumors (5/6), whereas mature T-cell lymphomas were essentially MAL negative (27/28). (nih.gov)
  • Mediastinal tumors are abnormal growths in your chest. (healthline.com)
  • Malignant mediastinal germ cell tumors of various histologies were first described as a clinical entity approximately 50 years ago. (health.am)
  • Mediastinal and other extragonadal germ cell tumors were initially thought to represent isolated metastases from an inapparent gonadal primary site. (health.am)
  • Extragonadal germ cell tumors, particularly those arising in mediastinal and pineal sites, represent a malignant transformation of germinal elements distributed to these sites and can occur in the absence of a primary focus in the gonad. (health.am)
  • They are much less common than germinal tumors arising in the testes, and account for only 1 to 5% of all germ cell neoplasms. (health.am)
  • These figures, most of which are derived from retrospective series reported between 1950 and 1975, may underestimate the true occurance of mediastinal germ cell tumors. (health.am)
  • The histology of these tumors may be similar to that of other malignant mediastinal tumors, including malignant thymoma and high-grade non-Hodgkin's lymphoma. (health.am)
  • Although there is no doubt that mediastinal germ cell tumors are uncommon, increasing familiarity with the tumors by both clinicians and pathologists will probably result in their increased recognition. (health.am)
  • The great majority of mediastinal malignant germ cell tumors occur in patients between 20 and 35 years of age. (health.am)
  • In the rare occurrences reported in females, mediastinal malignant germ cell tumors have appeared histologically and biologically identical to those occurring in males. (health.am)
  • In general, mediastinal germ cell tumors appear histologically identical to germ cell tumors arising in the testis, and all histologic subtypes seen in gonadal germ cell neoplasms have also been recognized in the mediastinum. (health.am)
  • In a recent review of 229 malignant mediastinal germ cell tumors seen between 1960 and 1994 at the Armed Forces Institute of Pathology, pure seminoma was the most common histology, accounting for 52% of cases. (health.am)
  • The complex anatomy of the mediastinum, as well as the different clinical, radiographic and prognostic features of mediastinal tumors suggests that specialists adopt more flexible and comprehensive practices, as highlighted in this text. (springer.com)
  • My research in thoracic neoplasms has focused on lung cancer, malignant mesothelioma, and mediastinal thymic tumors. (mskcc.org)
  • Thymic epithelial tumors (TET) are rare mediastinal neoplasms that can metastasize to the pleural space (stage IVA). (frontiersin.org)
  • Thymic epithelial tumors (TET) are rare neoplasms, but they are the most frequent anterior mediastinal tumors in adults. (frontiersin.org)
  • Primary mediastinal tumors. (springer.com)
  • Kovacs C.M., Gomez-Fernandez C. (2018) Ectopic Thyroid Tumors, Mediastinal. (springer.com)
  • The 2016 World Health Organization classification of lymphoid neoplasms recommends that immunohistochemistry and/or gene expression profiling be used to subclassify 'typical' DLBCL into tumors of germinal center and non-germinal center origin, in recognition that these two classes of tumors have different prognoses with current therapies [ 1 ]. (uptodate.com)
  • Gastrointestinal stromal tumors (GISTs) are relatively rare neoplasms of the gastrointestinal tract originating from the pluripotential mesenchymal stem cells, which differentiate into interstitial Cajal cells. (dovepress.com)
  • Mediastinal teratomata are rare, extragonadal germ cell tumors, which can occur at any age and are often asymptomatic. (cancerindex.org)
  • Neurogenic tumors, to include nerve sheath and sympathetic ganglion tumors, represent the most common posterior mediastinal masses. (jaocr.org)
  • Mediastinal germ cell tumors are tumors that derive from germ cell rest remnants in the mediastinum. (wikipedia.org)
  • Unlike benign germ cell tumors of the mediastinum, malignant mediastinal tumors are usually symptomatic at the time of diagnosis. (wikipedia.org)
  • Most mediastinal malignant tumors are large and cause symptoms by compressing or invading adjacent structures, including the lungs, pleura, pericardium, and chest wall. (wikipedia.org)
  • The treatment for mediastinal nonseminomatous germ cell tumors should follow guidelines for poor-prognosis testicular cancer. (wikipedia.org)
  • Syndromes associated with mediastinal germ cell tumors include Hematologic Neoplasia and Klinefelter's syndrome. (wikipedia.org)
  • Utility of immunohistochemistry in separating thymic neoplasms from germ cell tumors and metastatic lung cancer involving the anterior mediastinum. (semanticscholar.org)
  • We report an immunohistochemical (IHC) panel that includes CD5, placental-like alkaline phosphatase (PLAP), thyroid transcription factor 1 (TTF-1), cytokeratin (CK) 7, CK20, CK5/6, and CD57 for the separation of thymic neoplasms from germ cell tumors (GCTs) and metastatic lung malignancies. (semanticscholar.org)
  • Anterior mediastinal tumors usually arise from the thymus and paravertebral masses usually originate from the nerve sheath. (biomedcentral.com)
  • The most common mediastinal masses are neurogenic tumors (20% of mediastinal tumors), usually found in the posterior mediastinum, followed by thymoma (15-20%) located in the anterior mediastinum. (wikipedia.org)
  • Gray zone lymphoma: better treated like hodgkin lymphoma or mediastinal large B-cell lymphoma? (nih.gov)
  • Although primary mediastinal large B-cell lymphoma (PMBL) and classic Hodgkin lymphoma of the nodular sclerosis type (CHL-NS) are distinct diseases, they share several clinical characteristics and biologic features. (nih.gov)
  • Using a differential display reverse-transcription approach, we identified MAL as a distinct molecular marker of primary mediastinal large B-cell lymphoma compared with nonmediastinal diffuse large B-cell lymphomas. (nih.gov)
  • and to the primary mediastinal large B-cell lymphoma derived B-cell line MedB-1. (nih.gov)
  • In conclusion, this study further supports thymic B cells as the putative normal counterpart of primary mediastinal large B-cell lymphomas and supports MAL as a distinct molecular marker of this lymphoma subtype among diffuse large B-cell lymphomas. (nih.gov)
  • A cancerous neoplasm in your lymph tissues is referred to as lymphoma . (healthline.com)
  • Anaplastic large cell lymphoma (ALCL) is a mature T cell neoplasm that often expresses the CD4+ T cell surface marker. (jci.org)
  • A variant of t(14;18)-negative nodal diffuse follicular lymphoma (FL) with 1p36 deletion has been proposed in the 2017 World Health Organization (WHO) classification of lymphoid neoplasms. (medscape.com)
  • Primary diffuse large B cell lymphoma of the mediastinum, also called primary mediastinal large B cell lymphoma. (uptodate.com)
  • See 'Primary mediastinal large B cell lymphoma' . (uptodate.com)
  • Submit your Twitter account related to Mediastinal Large B-cell Lymphoma to be featured! (novusbio.com)
  • Submit your blog on Mediastinal Large B-cell Lymphoma to be featured! (novusbio.com)
  • Research of Mediastinal Large B-cell Lymphoma has been linked to Lymphoma, B-cell Lymphomas, Mediastinal (thymic) Large B-cell Lymphoma, Diffuse Large B-cell Lymphoma, Mediastinal Neoplasms. (novusbio.com)
  • The study of Mediastinal Large B-cell Lymphoma has been mentioned in research publications which can be found using our bioinformatics tool below. (novusbio.com)
  • These pathways complement our catalog of research reagents for the study of Mediastinal Large B-cell Lymphoma including antibodies and ELISA kits against DDIT3, BCL6, MID1, MME, TNFRSF8. (novusbio.com)
  • Explore more on Mediastinal Large B-cell Lymphoma below! (novusbio.com)
  • We have 3577 products for the study of Mediastinal Large B-cell Lymphoma that can be applied to Chromatin Immunoprecipitation, Flow Cytometry, Western Blot, Immunocytochemistry/Immunofluorescence, Immunohistochemistry, Chromatin Immunoprecipitation (ChIP) from our catalog of antibodies and ELISA kits. (novusbio.com)
  • Increased expression of CD30 is observed on some neoplasms including Hodgkin's disease (HD), anaplastic large cell lymphoma (ALCL), mediastinal B cell lymphoma, embryonal carcinoma, seminoma, and mesothelioma ( 2 - 7 ). (pnas.org)
  • There is also primary mediastinal B-cell lymphoma with exceptionally good prognosis. (wikipedia.org)
  • Examination of the anterior mediastinal mass biopsy in the 23 year old woman revealed type B1 thymoma which was confirmed after examination of the subsequent robotic thymectomy specimen. (ecu.edu)
  • The term, thymoma, is customarily used to describe neoplasms that show no overt atypia of the epithelial component. (healthlinkbc.ca)
  • Thymoma is a neoplasm of thymic epithelial cells. (medscape.com)
  • Clinical findings - Approximately 50 percent of patients with thymoma are asymptomatic at the time of diagnosis and are discovered incidentally, usually because a chest film or transthoracic echocardiogram obtained for an unrelated purpose is suggestive of an anterior mediastinal mass. 35% of patients present with myasthenia gravis or other tumor related syndromes (see below). (mypacs.net)
  • Thymoma is the most common neoplasm of the anterior mediastinum, originating within the epithelial cells of the thymus. (psychiatryadvisor.com)
  • There is a continuum of differentiation from thymoma to thymic carcinoma and primary thymic epithelial neoplasms can have features of both. (psychiatryadvisor.com)
  • Robotically enhanced mediastinal teratoma resection: a case report and review of the literature. (cancerindex.org)
  • A large minority of patients with a mediastinal teratoma (including dermoid cyst) will cough up hair. (wikipedia.org)
  • Background: Mediastinal mature teratoma is a rare primary germ cell neoplasm composed of welldifferentiated tissues derived from more than one of the three embryonic germ cell layers. (amjcaserep.com)
  • The incidence, etiology and diagnostic procedure of the posterior mediastinal teratoma is discussed. (amjcaserep.com)
  • Some patients with "poorly differentiated neoplasm" or "poorly differentiated carcinoma" of the mediastinum have the i(12p) chromosomal abnormality diagnostic of germ cell tumor. (health.am)
  • Metastatic carcinoma of thyroid origin in mediastinal lymph nodes may present as a mass lesion. (springer.com)
  • Rare presentation of occult medullary carcinoma of the thyroid as a mediastinal mass. (springer.com)
  • Management of anaplastic thyroid carcinoma spread over the trachea with mediastinal extension. (springer.com)
  • Mucoepidermoid thymic carcinoma: a challenging mediastinal aspirate. (semanticscholar.org)
  • In cases of mediastinal lymph node swelling following surgical treatment of urinary tract carcinoma (urothelial carcinoma and renal cell carcinoma), it is imperative that we consider the metastasis of the primary cancer. (elsevier.com)
  • In cases of mediastinal lymph node swelling following surgical treatment of urinary tract carcinoma, we should make an appropriate use of thoracoscopic lymph node biopsy. (elsevier.com)
  • Other inclusion criteria included capability of giving consent and adequate organ function to tolerate uniportal thoracoscopy mediastinal tumor resection. (clinicaltrials.gov)
  • It is indicated for the management of several cardiothoracic diseases, including mediastinal or lung mass resection, drainage of pleural effusions, palliative treatment of critical congenital heart disease and establishment of EXIT-to-extracorporeal membrane oxygenation (ECMO). (signavitae.com)
  • Patients undergoing oesophageal or cardia resection for cancer are monitored by mediastinal microdialysis during the postoperative period. (knowcancer.com)
  • Resection and reconstruction of the great mediastinal vessels in case of involved are technically challenging. (ersjournals.com)
  • After evaluation the patient underwent radical resection of the tumor en bloc with the involved vessels and reconstruction with Y-shaped gore-tex graft. (ersjournals.com)
  • Currently, resection of anterior mediastinal or paravertebral neoplasm is typically performed using minimally invasive procedures. (biomedcentral.com)
  • This clinical trial explored intraoperative near-infrared (NIR) imaging as an approach to improving tumor delineation during mediastinal tumor resection. (illinois.edu)
  • We experienced two cases where thoracoscopic mediastinal lymph node biopsy was successfully used for making a precise diagnosis and providing proper treatmen.The first case enabled a diagnosis of metastasis of urothelial cancer and the second case enabled a diagnosis of primary mediastinal lung cancer (TO lung cancer). (elsevier.com)
  • Background Anterior mediastinal masses are a rare but well documented finding in Graves disease. (ecu.edu)
  • The book includes a brief introductory section describing the anatomic sites of mediastinal masses and the epidemiological evidence for each different clinical-pathological entity. (springer.com)
  • The Mediastinal Mass: A Multidisciplinary Approach provides a valuable resource for clinicians, surgeons, radiologists and pathologists dealing with the management and treatment of mediastinal masses through a multidisciplinary approach. (springer.com)
  • While chest computed tomography (CT) is the mainstay for initial evaluation of mediastinal masses detected incidentally by radiography or by clinical presentation, CT results are frequently indeterminate. (appliedradiology.com)
  • Approximately 20% of goiters extend into the thorax, representing roughly 10% of mediastinal masses. (springer.com)
  • The three-compartment model proposed by Shields ( Figure 1 ) defines the anterior compartment, which lies between the posterior aspect of the sternal plate and the anterior aspect of the great vessels, and contains the thymus, the internal mammary vessels, the extra-pericardial aorta and its branches, the great veins, and lymphatic tissue (a summary of anterior mediastinal masses is found in Table II ). (clinicaladvisor.com)
  • The middle (visceral) compartment lies between the anterior aspect of the pericardium and the ventral aspect of the thoracic spine and is defined as the heart, the intrapericardial great vessels, the pericardium, and the trachea (a summary of the middle mediastinal masses if found in Table III ). (clinicaladvisor.com)
  • Most patients with mediastinal masses are asymptomatic, and masses are incidentally found on imaging. (clinicaladvisor.com)
  • Posterior mediastinal masses can arise from any of these structures. (jaocr.org)
  • Chest radiography depicted bilateral posterior mediastinal masses (Fig. 1). (thefreelibrary.com)
  • We conclude that patients with dysphagia and a history of previous mediastinal radiotherapy should undergo repeated endoscopy for biopsy. (symptoma.com)
  • Biopsy of the anterior mediastinal mass was obtained and subsequently the patient underwent robotic thymectomy. (ecu.edu)
  • Immunohistochemistry in the diagnosis of thymic epithelial neoplasms. (semanticscholar.org)
  • Classification of thymic epithelial neoplasms: a controversial issue coming to an end? (wikipedia.org)
  • Caution should be exercised when dismissing a mediastinal mass as benign thymic hyperplasia in patients with active Graves disease. (ecu.edu)
  • To properly diagnose neoplastic disease, your doctor will first determine if the neoplasms are benign or malignant. (healthline.com)
  • If you've been diagnosed with a benign neoplasm, your doctor may want to monitor your symptoms to detect any unusual activity. (healthline.com)
  • Mediastinal chondroma is a benign mesenchymal neoplasm composed of hyaline cartilage arising as an extraosseal mass in mediastinum. (springer.com)
  • Thoracic magnetic resonance imaging (MRI) offers a noninvasive way to further characterize mediastinal lesions, their site of origin, and their involvement of adjacent structures. (appliedradiology.com)
  • This article will discuss MR imaging technique and illustrate how the modality improves diagnostic specificity in mediastinal mass characterization by reviewing the features of selected mediastinal lesions and demonstrating how MR helps narrow the differential diagnosis, often to a single entity. (appliedradiology.com)
  • Conventional transbronchial needle aspiration (c-TBNA) contributed to improve the bronchoscopic examination, allowing to sample lesions located even outside the tracheo-bronchial tree and in the hilo-mediastinal district, both for diagnostic and staging purposes. (pubmedcentralcanada.ca)
  • Methods: Twenty-five subjects with anterior mediastinal lesions suspicious for malignancy were enrolled in an open-label feasibility trial. (illinois.edu)
  • Rare cases of adult onset acute megakaryoblastic leukemia are associated with malignant mediastinal germ cell tumor. (wikipedia.org)
  • In several of these cases, the genetic aberrations in the malignant megakaryoblasts were similar to those in the malignant mediastinal germ cells. (wikipedia.org)
  • Lateral radiograph confirmed the posterior location of the mediastinal lesion. (jaocr.org)
  • An anterior or middle mediastinal location is more common than posterior. (jaocr.org)
  • Frontal radiographs reveal a posterior mediastinal mass with the aortic shadow not seen separately from the lesion. (jaocr.org)
  • Extramedullary haematopoiesis: an uncommon posterior mediastinal mass. (thefreelibrary.com)
  • Only eighteen posterior mediastinal teratomas have been reported to date in the literature. (amjcaserep.com)
  • Conclusions: Mature cystic teratomas of the posterior mediastinum are distinct clinical entity that must be considered when caring for a patient with a posterior mediastinal mass. (amjcaserep.com)
  • The thoracic diseases including lung cancer, thymus neoplasm, cardiac surgery disease, aortic aneurysm, and mediastinal tumor of nervous tissue are prevalent. (hindawi.com)
  • CONCLUSION: In immune type Graves' disease with a mediastinal space-occupying lesion, not only intrathoracic goitre but also thymus hyperplasia should be considered in the differential diagnosis. (uni-regensburg.de)
  • However, the cardiotoxicity of mediastinal radiation is substantial and the standard treatment of mediastinal seminomas is with chemotherapy using bleomycin, etoposide and cisplatin for either three or four 21-day treatment cycles depending on the location of any metastatic disease. (wikipedia.org)
  • Treatment of mediastinal Hodgkin's involves chemotherapy and/or radiation. (wikipedia.org)
  • An anterosuperior mediastinal mass can be caused by neoplastic and non-neoplastic pathology. (radiopaedia.org)
  • Radiology revealed an upper mediastinal space-occupying lesion which scintigraphically was separate from thyroid tissue. (uni-regensburg.de)
  • Thyroid neoplasms are. (springer.com)
  • Mediastinal foregut cysts result from embryologic aberrations with anomalous budding of the primitive foregut. (jaocr.org)
  • Distant spread can occur to the pleura, the diaphragm, and occasionally the mediastinal lymph nodes. (clinicaladvisor.com)
  • Among B-cell lymphomas (n = 110), MAL expression in tumor cells was observed in 21/33 primary mediastinal large B-cell lymphomas (70%) and in 3/5 plasmacytoma/myeloma, but not in all other B-cell lymphomas with the exception of 1/33 nonmediastinal diffuse large B-cell lymphomas. (nih.gov)
  • citation needed] Of all cancers involving the same class of blood cell, 2% of cases are mediastinal large B cell lymphomas. (wikipedia.org)
  • so far the report of detailed 3D visible thoracic structures' model including lung and mediastinal structures is still not described. (hindawi.com)
  • We have evaluated the sensitivity, accuracy, positive predictive value (PPV) and negative predictive value (NPV) of the c-TBNA performed during the 2005-2015 period for suspicious lung neoplasia and/or hilar and mediastinal lymphadenopathy at the Thoracic endoscopy of the Thoracic Surgery Department of the Regina Elena National Cancer Institute, Rome. (pubmedcentralcanada.ca)
  • Intriguingly, the present case suffered from a left-sided thymic tumor and a right-sided lower thoracic paravertebral neoplasm. (biomedcentral.com)
  • The trial recruited patients aged from 18 to 75 years with a diagnosis of mediastinal tumor. (clinicaltrials.gov)
  • The c-TBNA proved to be an efficient method for the diagnosis/staging of lung neoplasms and for the diagnosis of mediastinal lymphadenopathy. (pubmedcentralcanada.ca)
  • Although neuroblastoma (NB) is one of the most common neoplasms in children, the Ministry of Health, Labour, and Welfare opted to halt the mass screening program for NB at 6 months of age in 2004. (omicsonline.org)
  • Neuroblastoma (NB) is one of the most common neoplasms in children. (omicsonline.org)
  • There are some potentially life-threatening manifestations of thymomic neoplasms like myasthenia gravis and superior vena cava syndrome. (ersjournals.com)
  • One in every 17 patients with primary mediastinal non-seminomatous GCTs develop an incurable hematologic malignancy and prior data intriguingly suggests a clonal relationship exists between hematologic malignancies and GCTs in these cases. (jci.org)
  • Here, we traced the clonal evolution and characterized the genetic features of each neoplasm from a cohort of fifteen patients with GCTs and associated hematologic malignancies. (jci.org)
  • Hematologic malignancies arising in this setting genetically resembled mediastinal GCTs rather than de novo myeloid neoplasms. (jci.org)
  • The palliative treatment of the mediastinal malignancies have poor prognosis and radical surgical therapy is the only option. (ersjournals.com)
  • This case represents a late and uncommon complication of mediastinal irradiation manifesting as a unilateral hyperlucent lung . (symptoma.com)
  • Symptoms may result from local compression or invasion of adjacent mediastinal structures. (clinicaladvisor.com)
  • Conversion was required in five cases, mostly for invasion of mediastinal structures. (elsevier.com)
  • Presence of a large mass, apparently from the middle mediastinum ( white arrows), diameters of 11 x 15 x 12 cm, homogeneous density, with the mass effect on other mediastinal structures (black arrows) and compression on the right upper lobe (*), without inner calcifications. (bvsalud.org)
  • It is also displacing mediastinal structures such as the trunk of the pulmonary artery (blue arrow), this mass is generating passive atelectasis of the right middle lobe (red arrow). (bvsalud.org)
  • Cases 12 year old boy with one year history of refractory Graves disease was found to have an anterior mediastinal mass and underwent curative thyroidectomy for sustained hyperthyroidism. (ecu.edu)
  • A 23 year old woman who presented with a one month history of hyperthyroid symptoms, was diagnosed with Graves disease and also was found to have an anterior mediastinal mass on imaging. (ecu.edu)
  • These cases indicate that an anterior mediastinal mass in a patient with active Graves disease may be due to a neoplastic cause, which may require definitive treatment. (ecu.edu)
  • Preoperative chest CT examination showed that shape of the mediastinal tumor was regular, boundary was clear, and maximum diameter of the mass was less than 4 cm. (clinicaltrials.gov)
  • This book discusses the main approaches for mediastinal mass diagnosis and treatment, whose different aspects have been thoroughly treated by a multidisciplinary team of experts from different clinical fields. (springer.com)
  • A large anterior mediastinal mass (white arrows) is seen on this contrast-enhanced CT of the chest. (learningradiology.com)
  • PA and lateral chest films are the first step in distinguishing from which mediastinal compartment the mass is arising from. (virtualpediatrichospital.org)
  • The initial evaluation of a patient with a mediastinal mass includes a thorough history and physical examination. (clinicaladvisor.com)
  • The diagnosis of a mediastinal germ cell tumor should be considered in all young males with a mediastinal mass. (wikipedia.org)
  • citation needed] Second most common primary anterior mediastinal mass in adults. (wikipedia.org)
  • Although thymomas account for about 20% of mediastinal neoplasms and are the most-common anterior mediastinal neoplasm , (1) the overall incidence of thymomas is rare. (thefreedictionary.com)
  • Pure mediastinal seminomas are curable in the large majority of patients, even when metastatic at the time of diagnosis. (wikipedia.org)

No images available that match "mediastinal neoplasms"