Medetomidine
Xylazine
Zolazepam
Hypnotics and Sedatives
Anesthetics, Combined
Adrenergic alpha-2 Receptor Agonists
Anesthetics, Dissociative
Intravenous anesthetics that induce a state of sedation, immobility, amnesia, and marked analgesia. Subjects may experience a strong feeling of dissociation from the environment. The condition produced is similar to NEUROLEPTANALGESIA, but is brought about by the administration of a single drug. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed)
Butorphanol
Guaifenesin
Imidazoles
Ketamine
Methotrimeprazine
A phenothiazine with pharmacological activity similar to that of both CHLORPROMAZINE and PROMETHAZINE. It has the histamine-antagonist properties of the antihistamines together with CENTRAL NERVOUS SYSTEM effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604)
Surgery, Veterinary
A board-certified specialty of VETERINARY MEDICINE, requiring at least four years of special education, training, and practice of veterinary surgery after graduation from veterinary school. In the written, oral, and practical examinations candidates may choose either large or small animal surgery. (From AVMA Directory, 43d ed, p278)
Veterinary Drugs
Drugs used by veterinarians in the treatment of animal diseases. The veterinarian's pharmacological armamentarium is the counterpart of drugs treating human diseases, with dosage and administration adjusted to the size, weight, disease, and idiosyncrasies of the species. In the United States most drugs are subject to federal regulations with special reference to the safety of drugs and residues in edible animal products.
Respiratory Rate
Midazolam
A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH.
Immobilization
Dexmedetomidine
Anesthetics
Anesthesia Recovery Period
Receptors, Biogenic Amine
Cell surface proteins that bind biogenic amines with high affinity and regulate intracellular signals which influence the behavior of cells. Biogenic amine is a chemically imprecise term which, by convention, includes the catecholamines epinephrine, norepinephrine, and dopamine, the indoleamine serotonin, the imidazolamine histamine, and compounds closely related to each of these.
Receptors, Adrenergic, alpha-2
A subclass of alpha-adrenergic receptors found on both presynaptic and postsynaptic membranes where they signal through Gi-Go G-PROTEINS. While postsynaptic alpha-2 receptors play a traditional role in mediating the effects of ADRENERGIC AGONISTS, the subset of alpha-2 receptors found on presynaptic membranes signal the feedback inhibition of NEUROTRANSMITTER release.
Cardiovascular System
Adrenergic alpha-Antagonists
Anesthesia
Dogs
Fentanyl
Dose-Response Relationship, Drug
Injections, Intramuscular
Cardiopulmonary effects of the alpha2-adrenoceptor agonists medetomidine and ST-91 in anesthetized sheep. (1/170)
To test the hypothesis that pulmonary alterations are more important than hemodynamic changes in alpha2-agonist-induced hypoxemia in ruminants, the cardiopulmonary effects of incremental doses of (4-[1-(2,3-dimethylphenyl)ethyl]-1H-imadazole) hydrochloride (medetomidine; 0.5, 1.0, 2.0, and 4 micrograms/kg) and 2-(2, 6-diethylphenylamino)-2-imidazol (ST-91; 1.5, 3.0, 6.0, and 12 micrograms/kg) were compared in five halothane-anesthetized, ventilated sheep using a placebo-controlled randomized crossover design. Pulmonary resistance (RL), dynamic compliance, and tidal volume changes in transpulmonary pressure (DeltaPpl) were determined by pneumotachography, whereas cardiac index (CI), mean pulmonary artery pressure (Ppa), and pulmonary artery wedge pressure (Ppaw) were determined using thermodilution and a Swan-Ganz catheter. The most important finding was the fall in partial pressure of oxygen in arterial blood (PaO2) after administration of medetomidine at a dose (0.5 micrograms/kg) 20 times less than the sedative dose. The PaO2 levels decreased to 214 mm Hg as compared with 510 mm Hg in the placebo-treated group. This decrease in PaO2 was associated with a decrease in dynamic compliance and an increase in RL, DeltaPpl, and the intrapulmonary shunt fraction without changes in heart rate, CI, mean arterial pressure, pulmonary vascular resistance, Ppa, or Ppaw. On the other hand, ST-91 only produced significant changes in PaO2 at the highest dose. After this dose of ST-91, the decrease in PaO2 was accompanied by a 50% decrease in CI and an increase in mean arterial pressure, Ppa, Ppaw, and the intrapulmonary shunt fraction without significant alterations of RL and DeltaPpl. The study suggests that the mechanism(s) by which medetomidine and ST-91 produce lower PaO2 are different and that drug-induced alterations in the pulmonary system are mainly responsible for the oxygen-lowering effect of medetomidine. (+info)Direct effects of alpha1- and alpha2-adrenergic agonists on spinal and cerebral pial vessels in dogs. (2/170)
BACKGROUND: The effects of adrenergic agonists, often used as local anesthetic additives or spinal analgesics, on spinal vessels have not been firmly established. The authors investigated the effects of alpha2- and alpha1-adrenergic agonists on spinal and cerebral pial vessels in vivo. METHODS: Pentobarbital-anesthetized dogs (n = 28) were prepared for measurement of spinal pial-vessel diameter in a spinal-window preparation. The authors applied dexmedetomidine, clonidine, phenylephrine, or epinephrine in three different concentrations (0.5, 5.0, and 50 microg/ml; [2.1, 1.9, 2.5, and 2.3] x [10(-6), 10(-5), and 10(-4)] M, respectively) under the window (one drug in each dog) and measured spinal pial arteriolar and venular diameters in a sequential manner. To enable the comparison of their effects on cerebral vessels, the authors also administered these drugs under a cranial window. RESULTS: On topical administration, each drug constricted spinal pial arterioles in a concentration-dependent manner. Phenylephrine and epinephrine induced a significantly larger arteriolar constriction than dexmedetomidine or clonidine at 5 microg/ml (8%, 11%, 0%, and 1%, respectively). Spinal pial venules tended to be less constricted than arterioles. In cerebral arterioles, greater constrictions were induced by dexmedetomidine and clonidine than those induced by phenylephrine and epinephrine (14%, 8%, 0%, and 1%, respectively). Cerebral pial venules tended to exhibit larger constrictions than cerebral arterioles (unlike in spinal vessels). CONCLUSION: Dexmedetomidine and clonidine constricted spinal vessels in a concentration-dependent manner, but such vasoconstrictions were smaller than those induced by phenylephrine and epinephrine. (+info)Anesthetic profile of dexmedetomidine identified by stimulus-response and continuous measurements in rats. (3/170)
This study characterizes the anesthetic profile of dexmedetomidine on the basis of steady-state plasma concentrations using defined stimulus-response, ventilatory, and continuous electroencephalographic (EEG) and cardiovascular effect measures in rats. At constant plasma concentrations of dexmedetomidine (range, 0.5-19 ng/ml), targeted and maintained by target-controlled infusion, the whisker reflex, righting reflex, startle reflex (to noise), tail clamp response, hot water tail-flick latency, and attenuation of heart rate (HR) increase associated with tail-flick (sympathoadrenal block) and corneal reflex, were assessed in 22 rats. EEG (power in 0.5- to 3.5-Hz frequency band), mean arterial pressure, and HR were recorded continuously. Blood gas values and arterial drug concentrations were determined regularly. The following steady-state plasma EC(50) values of dexmedetomidine (mean +/- S.E. nanograms per milliliter) were estimated: HR decrease (0.51 +/- 0.04), EEG (1.02 +/- 0.08), whisker reflex (1.09 +/- 0.10), sympathoadrenal block (1.85 +/- 0.80), mean arterial blood pressure increase (1.99 +/- 0.44), righting reflex (2.13 +/- 0.15), tail-flick latency (3.65 +/- 0.87), startle reflex (3.75 +/- 0.64), tail clamp (5.49 +/- 1.34), and corneal reflex (24.5 +/- 12.3). At the EC(50) value of tail clamp, ventilatory depression was minor. In rats, dexmedetomidine creates bradycardia, sedation/hypnosis, sympathoadrenal blocking effects, and blood pressure-increasing effects at plasma concentrations below 2.5 ng/ml. Higher plasma concentrations are needed to loose the startle reflex, tail-flick, tail clamp, and corneal reflex responses. Ventilatory depressant effects are minor. The applied EEG measure seems to reflect sedation/hypnosis but seems to have limited value to predict the deeper levels of analgesia and anesthesia of dexmedetomidine. (+info)Anesthesia of wood bison with medetomidine-zolazepam/tiletamine and xylazine-zolazepam/tiletamine combinations. (4/170)
This study was designed to evaluate 2 combinations for immobilization of bison. Seven wood bison received 1.5 mg/kg body weight (BW) of xylazine HCl + 1.5 mg/kg BW of zolazepam HCl and 1.5 mg/kg BW of tiletamine HCl on one occasion. The bison received 60 micrograms/kg BW of medetomidine HCl + 0.6 mg/kg BW of zolazepam HCl and 0.6 mg/kg BW of tiletamine HCL on another occasion. Xylazine was antagonized with 3 mg/kg BW of tolazoline HCl and medetomidine HCl was antagonized with 180 micrograms/kg (BW) of atipamezole HCl. Temporal characteristics of immobilization and physiological effects (acid-base status, thermoregulatory, cardiovascular, and respiratory effects) of the drug combinations were compared. Induction was significantly faster with xylazine HCl-zolazepam HCl/tiletamine HCl. Recovery following antagonist administration was significantly faster with medetomidine HCl-zolazepam HCl/tiletamine HCl. The average drug volumes required were 7.00 mL of xylazine HCl-zolazepam HCl/tiletamine HCL and 2.78 mL of medetomidine HCl-zolazepam HCl/tiletamine HCl. Hypoxemia, hypercarbia, and rumenal tympany were the major adverse effects with both drug combinations. (+info)Comparative cardiopulmonary effects of carfentanil-xylazine and medetomidine-ketamine used for immobilization of mule deer and mule deer/white-tailed deer hybrids. (5/170)
Three mule deer and 4 mule deer/white-tailed deer hybrids were immobilized in a crossover study with carfentanil (10 microg/kg) + xylazine (0.3 mg/kg) (CX), and medetomidine (100 microg/kg) + ketamine (2.5 mg/kg) (MK). The deer were maintained in left lateral recumbency for 1 h with each combination. Deer were immobilized with MK in 230+/-68 s (mean +/- SD) and with CX in 282+/-83 seconds. Systolic, mean and diastolic arterial pressure were significantly higher with MK. Heart rate, PaO2, PaCO2, pH, and base excess were not significantly different between treatments. Base excess and pH increased significantly over time with both treatments. Both treatments produced hypoventilation (PaCO2 > 50 mm Hg) and hypoxemia (PaO2 < 60 mm Hg). PaO2 increased significantly over time with CX. Body temperature was significantly (P<0.05) higher with CX compared to MK. Ventricular premature contractions, atrial premature contractions, and a junctional escape rhythm were noted during CX immobilization. No arrhythmias were noted during MK immobilization. Quality of immobilization was superior with MK, with no observed movement present for the 60 min of immobilization. Movement of the head and limbs occurred in 4 animals immobilized with CX. The major complication observed with both of these treatments was hypoxemia, and supplemental inspired oxygen is recommended during immobilization. Hyperthermia can further complicate immobilization with CX, reinforcing the need for supplemental oxygen. (+info)Combination of continuous intravenous infusion using a mixture of guaifenesin-ketamine-medetomidine and sevoflurane anesthesia in horses. (6/170)
The anesthetic and cardiovascular effects of a combination of continuous intravenous infusion using a mixture of 100 g/L guaifenesin-4 g/L ketamine-5 mg/L medetomidine (0.25 ml/kg/hr) and oxygen-sevoflurane (OS) anesthesia (GKM-OS anesthesia) in horses were evaluated. The right carotid artery of each of 12 horses was raised surgically into a subcutaneous position under GKM-OS anesthesia (n=6) or OS anesthesia (n=6). The end-tidal concentration of sevoflurane (EtSEV) required to maintain surgical anesthesia was around 1.5% in GKM-OS and 3.0% in OS anesthesia. Mean arterial blood pressure (MABP) was maintained at around 80 mmHg under GKM-OS anesthesia, while infusion of dobutamine (0.39+/-0.10 microg/kg/min) was necessary to maintain MABP at 60 mmHg under OS anesthesia. The horses were able to stand at 36+/-26 min after cessation of GKM-OS anesthesia and at 48+/-19 minutes after OS anesthesia. The cardiovascular effects were evaluated in 12 horses anesthetized with GKM-OS anesthesia using 1.5% of EtSEV (n=6) or OS anesthesia using 3.0% of EtSEV (n=6). During GKM-OS anesthesia, cardiac output and peripheral vascular resistance was maintained at about 70% of the baseline value before anesthesia, and MABP was maintained over 70 mmHg. During OS anesthesia, infusion of dobutamine (0.59+/-0.24 microg/kg/min) was necessary to maintain MABP at 70 mmHg. Infusion of dobutamine enabled to maintaine cardiac output at about 80% of the baseline value; however, it induced the development of severe tachycardia in a horse anesthetized with sevoflurane. GKM-OS anesthesia may be useful for prolonged equine surgery because of its minimal cardiovascular effect and good recovery. (+info)Cardiovascular effects of medetomidine, detomidine and xylazine in horses. (7/170)
The cardiovascular effects of medetomidine, detomidine, and xylazine in horses were studied. Fifteen horses, whose right carotid arteries had previously been surgically raised to a subcutaneous position during general anesthesia were used. Five horses each were given the following 8 treatments: an intravenous injection of 4 doses of medetomidine (3, 5, 7.5, and 10 microg/kg), 3 doses of detomidine (10, 20, and 40 microg/kg), and one dose of xylazine (1 mg/kg). Heart rate decreased, but not statistically significant. Atrio-ventricular block was observed following all treatments and prolonged with detomidine. Cardiac index (CI) and stroke volume (SV) were decreased with all treatments. The CI decreased to about 50% of baseline values for 5 min after 7.5 and 10 microg/kg medetomidine and 1 mg/kg xylazine, for 20 min after 20 microg/kg detomidine, and for 50 min after 40 microg/kg detomidine. All treatments produced an initial hypertension within 2 min of drug administration followed by a significant decrease in arterial blood pressure (ABP) in horses administered 3 to 7.5 microg/kg medetomidine and 1 mg/kg xylazine. Hypertension was significantly prolonged in 20 and 40 microg/kg detomidine. The hypotensive phase was not observed in 10 microg/kg medetomidine or detomidine. The changes in ABP were associated with an increase in peripheral vascular resistance. Respiratory rate was decreased for 40 to 120 min in 5, 7.5, and 10 microg/kg medetomidine and detomidine. The partial pressure of arterial oxygen decreased significantly in 10 microg/kg medetomidine and detomidine, while the partial pressure of arterial carbon dioxide did not change significantly. Medetomidine induced dose-dependent cardiovascular depression similar to detomidine. The cardiovascular effects of medetomidine and xylazine were not as prolonged as that of detomidine. (+info)Partial to complete antagonism by putative antagonists at the wild-type alpha(2C)-adrenoceptor based on kinetic analyses of agonist:antagonist interactions. (8/170)
1. Activation of the recombinant human alpha(2C)-adrenoceptor (alpha(2C) AR) by (-)-adrenaline in CHO-K1 cells transiently co-expressing a chimeric G(alpha q/i1) protein induced a rapid, transient Ca(2+) response with a high-magnitude followed by a low-magnitude phase which continued throughout the recorded time period (15 min). 2. Activation of the alpha(2C) AR by various alpha(2) AR agonists revealed the following rank order of high-magnitude Ca(2+) response [E(max) (%) versus 10 microM (-)-adrenaline]: UK 14304 (102+/-4)=talipexole (101+/-3)=(-)-adrenaline (100)=d-medetomidine (98+/-1)>oxymetazoline (81+/-4) reverse similarclonidine (75+/-5). 3. The methoxy- (RX 821002) and ethoxy-derivatives (RX 811059) of idazoxan and the dexefaroxan analogue atipamezole were fully effective as antagonists of both the high- and the low-magnitude Ca(2+) response. However, though acting as full antagonists of the high-magnitude response, the further putative alpha(2) AR antagonists idazoxan (27%), SKF 86466 (29%) and dexefaroxan (59%) reversed the low-magnitude response only partially. 4. In conclusion, kinetic analyses of agonist : antagonist interactions at the alpha(2C) AR demonstrate a wide spectrum of partial to complete antagonism of the low-magnitude Ca(2+) response for structurally related alpha(2) AR ligands. (+info)
Potential role of the CD38/cADPR signaling pathway as an underlying mechanism of the effects of medetomidine on insulin and...
Electroencephalographic Recordings in the Canine: Effects of Low Dose Medetomidine or Dexmedetomidine Followed by Atipamezole
Factory Supply Pain Killer Material Medetomidine CAS86347-14-0 Water Solution - Passionchemical
Partial intravenous anaesthesia in 5 horses using ketamine, lidocaine, medetomidine and halothane
Clinical efficacy and safety of propofol or ketamine anaesthesia in dogs premedicated with medetomidine | Veterinary Record
Medetomidine HCl | CAS: 86347-15-1
Effects of medetomidine and medetomidine-butorphanol combination on Schirmer tear test 1 readings in dogs
Atipamezole HCl | α2 adrenergic receptor antagonist | Buy Atipamezole HCl from Supplier AdooQ®
Hypertension sub-cluster 84
DETERGENT LEMON 1L - Dmed
The Effects of Intravenous Dexmedetomidine on Spinal Anesthesia Using Low Dose Diluted Bupivacaine for Transurethral Resection...
An isobolographic analysis of the hypnotic effects of combinations of dexmedetomidine with fentanyl or diazepam in rats<...
Dexmedetomidine for Sepsis in ICU Randomized Evaluation Trial - Tabular View - ClinicalTrials.gov
The efficacy of dexmedetomidine on lung injury induced by renal ischemia/reperfusion in diabetic rats | AVESİS
Effect of dexmedetomidine on the postoperative cognitive function of patients undergoing radical resection of esophageal cancer
DailyMed - DEXMEDETOMIDINE HYDROCHLORIDE injection, solution
PRECEDEX (dexmedetomidine hydrochloride injection) Use in Specific Populations | Pfizer Medical Information - Hong Kong
WG Critical Care Is The Only Company To Offer Two Unique Dexmedetomidine Hydrochloride Injection Presentations - WG Critical...
PRECEDEX (dexmedetomidine hydrochloride injection) Use in Specific Populations | Pfizer Información Médica - República de...
Subject: sedatives - PubAg Search Results
Effects of Dexmedetomidine on Stress Response and Postoperative Analgesia in Patients Undergoing Thoracotomy During Anesthesia...
DEXMEDETOMIDINE (dexmedetomidine hydrochloride injection, solution, concentrate) | Pharmacological Profile | Healthgrades.com
PRIME PubMed | A double-blind, placebo-controlled trial of four fixed rate infusion regimens of phenylephrine for hemodynamic...
Dexmedetomidine attenuates lung injury induced by liver ischemiareperfusion injury in rats | Abstract
Dexmedetomidine use in the ICU: Are we there yet? (Pham) | Pediatric Critical Care Evidence
Dexmedetomidine hydrochloride | Abcam
Dexmedetomidine Manufacturer By Daicel
Publications: Cullen, Len - Murdoch Research Repository
5??-Reductase | Beneficial Effects of RAF Inhibitor i
Zonisamide - 5
ROLE OF DEXMEDETOMIDINE AS AN ANAESTHETIC ADJUVANT FOR LAPROSCOPIC SURGERY. - AdisInsight
Dexmedetomidine Side Effects in Detail - Drugs.com
Dexmedetomidine (Precedex) | Daviss Drug Guide
Clinicophysiological and haemodynamic effects of fentanyl with xylazine, medetomidine and dexmedetomidine in isoflurane...
Effect of Dexmedetomidine on Cerebral Blood Flow Velocity, Cerebral Metabolic Rate, and Carbon Dioxide Response in Normal...
PRECEDEX (dexmedetomidine hydrochloride injection) Clinical Pharmacology | Pfizer Medical Information - Italy (Repubblica...
IJMS | Free Full-Text | Perineural Dexmedetomidine Attenuates Inflammation in Rat Sciatic Nerve via the NF-κB Pathway
Effect of intravenous infusion of dexmedetomidine on perioperative haemodynamic changes and postoperative recovery: A study...
Respiratory effect of dexmedetomidine: As a sedative for sub-dural haematoma evacuation<...
Total knee arthroplasty under quadruple nerve block with ropivacaine 0.32%: effect of addition of intravenous dexmedetomidine...
Effects of a constant rate infusion of magnesium sulphate in healthy dogs anaesthetized with isoflurane and undergoing...
A prospective randomized double blind study to find out the efficacy of Dexmedetomidine 1μcg/kg single infusion as an adjuvant...
The effects of dexmedetomidine on liver ischemia-reperfusion injury in rats. - PubMed - NCBI
The effects of dexmedetomidine against ruptured abdominal aortic aneurysm injury to myocardial tissue induced by abdominal...
DEXMEDETOMIDINE HYDROCHLORIDE (injection, solution) | Pictures, Images, Labels | Healthgrades.com
Remifentanil Intraoperative Analgesia. A Comparative Study With Fentanyl in Dogs - WSAVA2002 - VIN
Atipamezole medication guide
DEXMEDETOMIDINE HYDROCHLORIDE - Slayback Pharma LLC, Page 4
Article Metrics] Dexmedetomidine attenuates myocardial inflammation | JIR
Dexmedetomidine Drug Interactions - Drugs.com
Cardiovascular effects of dexmedetomidine sedation in children
CERVICAL COLLAR A - Anatomic - H 8cm skin SMALL 33-38 CM - Dmed
ATC 코드 N05 - 위키백과, 우리 모두의 백과사전
QN05CM91 Medetomidine. QN05CM92 Xylazine. QN05CM93 Romifidine. QN05CM94 Metomidate. N05CX 바르비탈계를 제외한 수면진정제의 조합[편집]. N05CX01 ...
Analgesic nephropathy
"Effects of carprofen on renal function during medetomidine-propofol-isoflurane anesthesia in dogs". American journal of ...
4-NEMD
Zhang, X; Yao, XT; Dalton, JT; Shams, G; Lei, L; Patil, PN; Feller, DR; Hsu, FL; George, C (1996). "Medetomidine analogs as ... Zhang, X; De Los Angeles, JE; He, MY; Dalton, JT; Shams, G; Lei, L; Patil, PN; Feller, DR; Miller, DD (1997). "Medetomidine ... Lalchandani, SG; Zhang, X; Hong, SS; Liggett, SB; Li, W; Moore Bm, 2nd; Miller, DD; Feller, DR (2004). "Medetomidine analogs as ... 3. Synthesis and biological evaluation of a new series of medetomidine analogs and their potential binding interactions with ...
Alpha-adrenergic agonist
Medetomidine, an α2 adrenergic agonist. Nonspecific agonists act as agonists at both alpha-1 and alpha-2 receptors. ... "A review of the physiological effects of alpha2-agonists related to the clinical use of medetomidine in small animal practice ... Tizanidine Medetomidine Methyldopa Methylnorepinephrine Norepinephrine (R)-3-nitrobiphenyline is an α2C selective agonist as ...
Detomidine
Medetomidine Dexmedetomidine Clarke, Kathy W.; Hall, Leslie W.; Trim, Cynthia M., eds. (2014). "Principles of sedation, ...
4-NEMD
It has two isomers, with the (S) isomer being the more potent, as with medetomidine. 4-NEMD was also investigated by the United ... September 1997). "Medetomidine analogs as alpha 2-adrenergic ligands. 3. Synthesis and biological evaluation of a new series of ... July 1996). "Medetomidine analogs as alpha 2-adrenergic ligands. 2. Design, synthesis, and biological activity of ... January 2004). "Medetomidine analogs as selective agonists for the human alpha2-adrenoceptors". Biochemical Pharmacology. 67 (1 ...
Atipamezole
... and because medetomidine is sold as 1 mg/mL, 1 mL of atipamezole reverses 1 mL of medetomidine. When the enantiomerically pure ... Atipamezole is sold at 5 mg/mL for ease of use: 5 times as much atipamezole as medetomidine is needed for full reversal, ... Kim MS, Jeong SM, Park JH, Nam TC, Seo KM (October 2004). "Reversal of medetomidine-ketamine combination anesthesia in rabbits ... ISBN 978-0-8138-2061-3. Talke P, Harper D, Traber L, Richardson CR, Traber D (February 1999). "Reversal of medetomidine induced ...
Veterinary surgery
Xylazine is approved for use in dogs, cats, horses, deer, and elk in the United States, while medetomidine is only approved for ... α2 agonists like xylazine and medetomidine are especially useful because they can be reversed, xylazine by yohimbine and ... Sedatives commonly used include acepromazine, hydromorphone, midazolam, diazepam, xylazine, and medetomidine. ...
Romifidin - Википедија, слободна енциклопедија
Sedative and cardiorespiratory effects of three doses of romifidine in comparison with medetomidine in five cats. Veterinary ...
Tiletamine
Caulkett, N.A.; Cattet, M.R.; Cantwell, S.; Cool, N.; Olsen, W. (January 2000). "Anesthesia of wood bison with medetomidine- ...
Dart injection
Ryeng, K. A.; Larsen, S.; Arnemo, J. M. (2002). "Medetomidine-Ketamine in Reindeer (Rangifer Tarandus Tarandus): Effective ...
Zolazepam
... medetomidine-ketamine, and medetomidine-zolazepam-tiletamine". Journal of Zoo and Wildlife Medicine. 30 (3): 354-60. PMID ...
Savannah cat
Ketamine has been found safe for use in servals together with medetomidine and butorphanol and with the antagonist atipamezole ... "Evaluation of the effects of naloxone on recovery time and quality after ketamine-medetomidine-butorphanol anesthesia in ... "Cardiopulmonary and anesthetic effects of medetomidine-ketamine-butorphanol and antagonism with atipamezole in servals (Felis ...
Romifidine
"Sedative and cardiorespiratory effects of three doses of romifidine in comparison with medetomidine in five cats". The ...
Surgical stress
"Evaluation of the perioperative stress response in dogs administered medetomidine or acepromazine as part of the preanesthetic ... different aspects of manifestation and characteristics with medetomidine and acepromazine preanaesthetic medication (PDF). ...
Japanese macaque
"Chemical restraint by medetomidine and medetomidine-midazolam and its reversal by atipamezole in Japanese macaques ('Macaca ...
Gladys Kalema-Zikusoka
Comparison of the cardiopulmonary effects of medetomidine-butorphanol-ketamine and medetomidine-butorphanol- midazolam in patas ...
Balanced anesthesia
The first advantage is balanced anesthesia can make patients calm by using the drugs, such as: medetomidine, diazepam or ...
Hoffmann's two-toed sloth
"Immobilization of free-ranging Hoffmann's two-toed and brown-throated three-toed sloths using ketamine and medetomidine: a ...
Butorphanol
For sedation, it may be combined with tranquilizers such as alpha-2 agonists (medetomidine), benzodiazepines, or acepromazine ...
Saltwater crocodile
... crocodiles with medetomidine and reversal with atipamezole". Veterinary Anaesthesia and Analgesia. 39 (4): 345-356. doi:10.1111 ...
Niaprazine
... (INN) (brand name Nopron) is a sedative-hypnotic drug of the phenylpiperazine group.[1][2] It has been used in the treatment of sleep disturbances since the early 1970s in several European countries including France, Italy, and Luxembourg.[3][4] It is commonly used with children and adolescents on account of its favorable safety and tolerability profile and lack of abuse potential.[5][6][7][8][9][10] Originally believed to act as an antihistamine and anticholinergic,[11] niaprazine was later discovered to have low or no binding affinity for the H1 and mACh receptors (Ki = , 1 μM), and was instead found to act as a potent and selective 5-HT2A and α1-adrenergic receptor antagonist (Ki = 75 nM and 86 nM, respectively).[12] It possesses low or no affinity for the 5-HT1A, 5-HT2B, D2, and β-adrenergic, as well as at SERT and VMAT (Ki = all , 1 μM), but it does have some affinity for the α2-adrenergic receptor (Ki = 730 nM),[12] likely acting as an antagonist there as well. Niaprazine ...
ICI-118,551
... is a selective β2 adrenergic receptor (adrenoreceptor) antagonist or beta blocker[1][2] . ICI binds to the β2 subtype with at least 100 times greater affinity than β1 or β3, the two other known subtypes of the beta adrenoceptor.[3][4] The compound was developed by Imperial Chemical Industries, which was acquired by AkzoNobel in 2008. ICI-118,551 has no known therapeutic use in humans although it has been used widely in research to understand the action of the β2 adrenergic receptor, as few other specific antagonists for this receptor are known.[5] ICI-118,551 has been used in pre-clinical studies using murine models.[6][7][8] When dissolved in saline, the compound crosses the blood-brain barrier. Common systemic doses used in rodent research are 0.5 or 1 mg/kg although efficacy has been demonstrated at doses as low as 0.0001 mg/kg in rhesus monkeys.[9] Doses up to 20 mg/kg have been used without toxicity. At room temperature in saline, the ICI 118,551 hydrochloride is soluble to ...
Captodiame
... (INN), also known as captodiamine, is an antihistamine sold under the trade names Covatine, Covatix, and Suvren which is used as a sedative and anxiolytic. The structure is related to diphenhydramine.[1] A 2004 study suggested captodiame may be helpful in preventing benzodiazepine withdrawal syndrome in people discontinuing benzodiazepine treatment.[1] In addition to its actions as an antihistamine, captodiamine has been found to act as a 5-HT2C receptor antagonist and σ1 receptor and D3 receptor agonist.[2] It produces antidepressant-like effects in rats.[2] However, captodiamine is unique among antidepressant-like drugs in that it increases brain-derived neurotrophic factor (BDNF) levels in the hypothalamus but not in the frontal cortex or hippocampus.[2] This unique action may be related to its ability to attenuate stress-induced anhedonia and corticotropin-releasing factor (CRF) signaling in the hypothalamus.[2] ...
Paraldehyde
... is the cyclic trimer of acetaldehyde molecules.[2] Formally, it is a derivative of 1,3,5-trioxane. The corresponding tetramer is metaldehyde. A colourless liquid, it is sparingly soluble in water and highly soluble in ethanol. Paraldehyde slowly oxidizes in air, turning brown and producing an odour of acetic acid. It quickly reacts with most plastics and rubber. Paraldehyde was first observed in 1835 by the German chemist Justus Liebig; its empirical formula was determined in 1838 by Liebig's student Hermann Fehling.[3][4] Paraldehyde was first synthesized in 1848 by the German chemist Valentin Hermann Weidenbusch (1821-1893), another student of Liebig; he obtained paraldehyde by treating acetaldehyde with acid (either sulfuric or nitric acid).[5][6] It has uses in industry and medicine. ...
Ergoline
There are a variety of clinically useful ergoline derivatives for the purpose of vasoconstriction, the treatment of migraines, and treatment of Parkinson's disease. Ergoline alkaloids found their place in pharmacology long before modern medicine as preparations of ergot were often used by midwives in the 12th century to stimulate childbirth.[10] Following Arthur Stoll's isolation of ergometrine, the therapeutic use of ergoline derivatives became well explored. The induction of uterine contractions via the preparation of ergot was attributed to ergonovine, an ergoline derivative found in ergot, which is a powerful oxytocic. From this, methergine, a synthetic derivative, was elucidated.[7] While used to facilitate child birth, ergoline derivatives can pass into breast milk and should not be used during breastfeeding.[11] They are uterine contractors that can increase the risk of miscarriage during pregnancy.[3] Another example of medically relevant ergoline alkaloids is ergotamine, an alkaloid ...
1,1,1-Trichloroethane
... is generally considered a non-polar solvent. Owing to the good polarizability of the chlorine atoms, it is a superior solvent for organic compounds that do not dissolve well in hydrocarbons such as hexane. It is an excellent solvent for many organic materials and also one of the least toxic of the chlorinated hydrocarbons. Prior to the Montreal Protocol, it was widely used for cleaning metal parts and circuit boards, as a photoresist solvent in the electronics industry, as an aerosol propellant, as a cutting fluid additive, and as a solvent for inks, paints, adhesives, and other coatings. 1,1,1-Trichloroethane is also used as an insecticidal fumigant. It was also the standard cleaner for photographic film (movie/slide/negatives, etc.). Other commonly available solvents damage emulsion, and thus are not suitable for this application. The standard replacement, Forane 141 is much less effective, and tends to leave a residue. 1,1,1-Trichloroethane was used as a thinner in ...
Menthyl isovalerate
... , also known as validolum, is the menthyl ester of isovaleric acid. It is a transparent oily, colorless liquid with a smell of menthol. It is very slightly soluble in ethanol, while practically insoluble in water. It is used as a food additive for flavor and fragrance.[1] ...
Levobunolol
The most common side effect is eye irritation felt as stinging or burning, which occurs in up to a third of patients. Blepharoconjunctivitis occurs in up to 5% of patients. Rarer adverse effects include keratitis, edema and increased lacrimation.[2][3] Allergies are rare, but seem to be more common than under the related drug timolol.[1] If the substance reaches the nasal mucosa via the tear duct, it can be absorbed into the bloodstream and cause systemic side effects. These include orthostatic hypotension (low blood pressure) and other effects on the heart and circulatory system, breathing problems in people with asthma, and skin symptoms such as itching and aggravation of psoriasis.[1] ...
Capsinolol
InChI=1S/C23H40N2O4/c1-5-6-7-8-9-10-11-23(27)25-15-19-12-13-21(22(14-19)28-4)29-17-20(26)16-24-18(2)3/h12-14,18,20,24,26H,5-11,15-17H2,1-4H3,(H,25,27 ...
Medetomidine - Wikipedia
Medetomidine is a synthetic drug used as both a surgical anesthetic and analgesic. It is often used as the hydrochloride salt, ... Medetomidine can be used as an antifouling substance in marine paint. It is mainly effective against barnacles, but has also ... Medetomidine has also been used in combination with morphine (or methadone), lidocaine and ketamine in constant rate infusion ... The free base form of medetomidine is sold as Selektope for use as an antifouling substance in marine paints. In veterinary ...
Medetomidine | definition of medetomidine by Medical dictionary
... medetomidine explanation free. What is medetomidine? Meaning of medetomidine medical term. What does medetomidine mean? ... Looking for online definition of medetomidine in the Medical Dictionary? ... medetomidine. Also found in: Wikipedia. medetomidine. a potent α2 adrenoreceptor agonist used widely as a sedative, hypnotic ... Medetomidine , definition of medetomidine by Medical dictionary https://medical-dictionary.thefreedictionary.com/medetomidine ...
COMPARISON OF ETORPHINE-DETOMIDINE AND MEDETOMIDINE-KETAMINE ANESTHESIA IN CAPTIVE ADDAX (ADDAX NASOMACULATUS)
EVALUATION OF MEDETOMIDINE-KETAMINE ANESTHESIA WITH ATIPAMEZOLE REVERSAL IN AMERICAN ALLIGATORS... MEDETOMIDINE-KETAMINE- ... CAPTURE AND MEDETOMIDINE KETAMINE ANESTHESIA OF FREE RANGING WOLVERINES (GULO... MASS CAPTURE AND ANESTHESIA OF AUSTRALIAN ... Timothy J. Portas, Michael J. Lynch, and Larry Vogelnest "COMPARISON OF ETORPHINE-DETOMIDINE AND MEDETOMIDINE-KETAMINE ... ETORPHINE-KETAMINE-MEDETOMIDINE TOTAL INTRAVENOUS ANESTHESIA IN WILD IMPALA (AEPYCEROS MELAMPUS) OF... ...
Electroencephalographic Recordings in the Canine: Effects of Low Dose Medetomidine or Dexmedetomidine Followed by Atipamezole
Each dog had an awake, baseline recording followed by an EEG performed after administration of low dose medetomidine (2 μg/kg ... After medetomidine and atipamezole, EEG waveforms were slower. Following atipamezole, however, the frequencies were observed to ... Administration of low dose medetomidine or dexmedetomidine followed by atipamezole reliably reduced the impact of movement ... appearance in the awake dog and compare these results with EEG recordings after low dose medetomidine (2 μg/kg IV) followed by ...
Medetomidine hydrochloride | CAS 86347-15-1 | Tocris Bioscience
2023) has been withdrawn from sale for commercial reasons and replaced by Medetomidine hydrochloride (Cat. No. 5160). ... Reviews for Medetomidine hydrochloride. There are currently no reviews for this product. Be the first to review Medetomidine ... Keywords: Medetomidine hydrochloride, Medetomidine hydrochloride supplier, Potent, selective, α2-adrenoceptor, alpha2- ... Medetomidine hydrochloride. Cat. No. 2023 Submit a Review Datasheet / COA / SDS Discontinued Product. This product has been ...
Immobilization of Norwegian reindeer (Rangifer tarandus tarandus) and Svalbard Reindeer (R. t. platyrhynchus) with medetomidine...
Doses of 50-200 micrograms/kg medetomidine alone or 30-125 micrograms/kg medetomidine combined with greater than or equal to ... with medetomidine and medetomidine-ketamine and reversal of immobilization with atipamezole.. Tyler NJ1, Hotvedt R, Blix AS, ... Atipamezole successfully antagonized medetomidine (-ketamine) resulting in rapid and persistent reversal of immobilization in ... The sedative action of medetomidine (-ketamine) was studied in 12 captive Norwegian semidomesticated reindeer (NR), including 4 ...
Anaesthetic and cardiopulmonary effects of intramuscular morphine, medetomidine and ketamine administered to telemetered cats.
... medetomidine, ketamine (MMK) drug combination were determined in cats. Six healthy, adult female cats were administered 0.2 mg/ ... Six healthy, adult female cats were administered 0.2 mg/kg morphine sulphate, 60 microg/kg medetomidine hydrochloride, and 5 mg ... The quality and duration of anaesthesia, cardiorespiratory effects and recovery characteristics of a morphine, medetomidine, ...
Medication for Analgesia - Medetomidine Injection Solution
Medetomidine preparation information is provided by Wedgewood Pharmacy. ... Medetomidine Injection Solution may be prescribed for Analgesia. ... Medetomidine Injection Solution. Prescribed For: Dogs, Cats and ... The dosage form available for Medetomidine is Injection Solution. 2 strengths of Medetomidine Injection Solution are available ... Medetomidine Injection Solution. Prescribed For: Dogs, Cats and Exotics. May be Prescribed For: Analgesia and Sedation. If you ...
Medetomidine from Vetstream | Definitive Veterinary Intelligence
Medetomidine Synonym(s): Medetomidine HCl, Domitor, Domtor, Zalopine, Dorbene, Dormilan, Medetor, Sedastart, Sedator, Sededorm ... Schernthaner A, Lendl C E, Hartmann K et al (2011) Medetomidine/midazolam/ketamine anaesthesia in ferrets: effects on ... When used for premedication, medetomidine will significantly reduce the dose of all other anesthetic agents. ... Anaesthetic effects in the ferret of alfaxalone alone and in combination with medetomidine or tramadol: a pilot study. Lab Anim ...
Partial intravenous anaesthesia in 5 horses using ketamine, lidocaine, medetomidine and halothane
KRUGER, K and STEGMANN, G F. Partial intravenous anaesthesia in 5 horses using ketamine, lidocaine, medetomidine and halothane. ... ketamine and medetomidine together with halothane inhalation anaesthesia. Mean end-tidal halothane concentration to maintain a ... ketamine and medetomidine together with halothane resulted in haemodynamically stable anaesthesia, followed by smooth recovery. ...
Medetomidine use in dogs | Vetlexicon Canis from Vetstream | Definitive Veterinary Intelligence
Medetomidine use in rabbits | Vetlexicon Lapis from Vetstream | Definitive Veterinary Intelligence
Find details on Medetomidine. Medication for rabbits including uses, administration, pharmacokinetics, precautions, adverse ... Difilippo S M, Norberg P J, Suson U D et al (2004) A comparison of xylazine and medetomidine in an anesthetic combination in ... Orr H E, Roughan J V & Flecknell P A (2005) Assessment of ketamine and medetomidine anaesthesia in the domestic rabbit. Vet ... Flecknell P A & Liles J H (1996) Halothane anaesthesia in the rabbit - a comparison of the effects of medetomidine, ...
Effects of medetomidine and medetomidine-butorphanol combination on Schirmer tear test 1 readings in dogs
Medetomidine is a commonly used sedative in veterinary medicine whether administered alone or in combination with an opioid ... Effects of medetomidine and medetomidine-butorphanol combination on Schirmer tear test 1 readings in dogs Vet Ophthalmol. Jan- ... Results revealed that intravenous sedation with medetomidine and medetomidine-butorphanol in dogs with no history of ophthalmic ... Medetomidine is a commonly used sedative in veterinary medicine whether administered alone or in combination with an opioid ...
Clinical efficacy and safety of propofol or ketamine anaesthesia in dogs premedicated with medetomidine | Veterinary Record
Medetomidine was administered intramuscularly at a dose of 1000 μg/m2 body surface area 10 to 15 minutes before the induction ... Combinations of medetomidine with either propofol or ketamine were compared for the sedation and induction of anaesthesia in ... The dogs became sedated by medetomidine after a mean (sd) time of 6.7 (5.4) minutes, and their heart rates and respiration ... Clinical efficacy and safety of propofol or ketamine anaesthesia in dogs premedicated with medetomidine ...
The effect of a combination of medetomidine-butorphanol and medetomidine, butorphanol, atropine on glomerular filtration rate...
The effects of intramuscularly administered medetomidine and butorphanol (MB), and ... The effect of a combination of medetomidine-butorphanol and medetomidine, butorphanol, atropine on glomerular filtration rate ... The effects of intramuscularly administered medetomidine and butorphanol (MB), and medetomidine, butorphanol, atropine (MBA) on ... The results of this study indicate that the administration of medetomidine in combination with butorphanol significantly ...
Evaluation of the cardiorespiratory effects of the alpha-2 adrenoceptor agonists xylazine, medetomidine and dexmedetomidine in...
... medetomidine and dexmedetomidine in combination with ketamine in dogs , O. Guzel, D.A. Kaya, K. Altunatmaz, G. Sevim, D. Sezer ... The second group, the medetomidine/ketamine group, intravenously received medetomidine (10 µg/kg) followed by ketamine (5 mg/kg ... If medetomidine is used, special care should be taken because of the rapid decrease in heart rate. ... The end tidal carbon dioxide levels were higher in the medetomidine/ketamine group than in the other two groups, and oxygen ...
Potential role of the CD38/cADPR signaling pathway as an underlying mechanism of the effects of medetomidine on insulin and...
Methods: Wild-type (WT) and CD38-knockout (CD38-/-) mice received medetomidine (50 μg kg-1) or a similar volume of 0.9% NaCl ( ... Correspondingly, medetomidine caused a significantly greater increase in plasma glucose concentrations in the WT than in the ... Correspondingly, medetomidine caused a significantly greater increase in plasma glucose concentrations in the WT than in the ... Correspondingly, medetomidine caused a significantly greater increase in plasma glucose concentrations in the WT than in the ...
Neurohormonal and metabolic effects of medetomidine compared with xylazine in beagle dogs. - Semantic Scholar
Both medetomidine and xylazine increased glucose levels. The hyperglycemic effect of medetomidine, in contrast with xylazine, ... Both medetomidine and xylazine similarly and dose-dependently inhibited norepinephrine release and lipolysis. Medetomidine ... The results suggested that the effect of medetomidine on glucose metabolism may not be due only to alpha2-adrenoceptor-mediated ... and 80 microg/kg medetomidine, and 1, 2, 4, and 8 mg/kg xylazine, intramuscularly. Blood samples were taken at 10 times during ...
Medetomidine HCl | CAS: 86347-15-1
yog ib qho kev kawm medetomidine hcl, cas 86347-15-1 chaw ua hauj lwm thiab cov chaw muag khoom nrog lub Hoobkas, txais tos ... yuav medetomidine hcl, cas 86347-15-1 cov khoom los ntawm peb. ... Medetomidine HCl CAS: 86347-15-1 cov lus qhia kom ntxaws *. ... Nqe lus piav txog Medetomidine HCl CAS: 86347-15-1: Medetomidine yog ib hom tshuaj siv hluavtaws siv los ua ob qho kev phais ... Medetomidine yog ib hom tshuaj siv hluavtaws siv los ua ob qho kev phais thiab kev mob nkeeg. Nws yog siv raws li cov ...
Medetomidine Premedication for Caesarean Section in the Bitch - Vet360
... over medetomidine 67. The primary author observed no differences in clinical effects when medetomidine is replaced by ... is reduced when using medetomidine at the low dose of 7 µg/kg. Therefore, the author uses 10 µg/kg medetomidine premedication ... of medetomidine. Although dexmedetomidine and medetomidine induced similar clinical effects 66, there are theoretical ... The use of medetomidine as premedicant permits the use of less than half the induction dose of propofol usually required when ...
Medetomidine of Muscle Growth Steroids from China Suppliers - 159073265
Determination of acepromazine, ketamine, medetomidine, and xylazine in serum: Multi-residue screening by liquid chromatography...
Miksa, I. R., Cummings, M. R., & Poppenga, R. H. (2005). Determination of acepromazine, ketamine, medetomidine, and xylazine in ... Miksa, IR, Cummings, MR & Poppenga, RH 2005, Determination of acepromazine, ketamine, medetomidine, and xylazine in serum: ... Fingerprint Dive into the research topics of Determination of acepromazine, ketamine, medetomidine, and xylazine in serum: ... T1 - Determination of acepromazine, ketamine, medetomidine, and xylazine in serum. T2 - Multi-residue screening by liquid ...
Xylazine or medetomidine premedication before propofol anaesthesia - Murdoch University Research Repository
... medetomidine (30 micrograms/kg intramuscularly), xylazine plus propofol (3 mg/kg intravenously) and medetomidine plus propofol ... Xylazine and medetomidine premedication prolonged propofol anaesthesia in dogs. Propofol alone reduced blood pressure and ... Bradycardia was a common feature in all the dogs given xylazine or medetomidine, but hypertension was consistently recorded in ... 1993) Xylazine or medetomidine premedication before propofol anaesthesia. Veterinary Record, 132 (15). pp. 378-83. ...
Comparison of the effects of xylazine bolus versus medetomidine constant rate infusion on the stress response, urine production...
For the MCRI treatment, end-tidal isoflurane concentration was maintained at 1.4% and medetomidine (0.005 mg/kg/h [0.0023 mg/lb ... OBJECTIVE: To compare the effect of xylazine bolus versus medetomidine constant rate infusion (MCRI) on serum cortisol and ... Comparison of the effects of xylazine bolus versus medetomidine constant rate infusion on the stress response, urine production ... Comparison of the effects of xylazine bolus versus medetomidine constant rate infusion on the stress response, urine production ...
Factory Supply Pain Killer Material Medetomidine CAS86347-14-0 Water Solution - Passionchemical
Medetomidine Synonyms: Medetomidine;4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole;( -)-4-(alpha,2,3-Trimethylbenzyl)imidazole;( ... Product Description Medetomidine Factory Supply Pain Killer Material Medetomidine CAS86347-14-0 Water Solution Medetomidine ... Medetomidine. Synonyms:. Medetomidine;4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole;( -)-4-(alpha,2,3-Trimethylbenzyl)imidazole ... Factory Supply Pain Killer Material Medetomidine CAS86347-14-0 Water Solution. * by chemicals ...
Glutamatergic synaptic input to glioma cells drives brain tumour progression | Nature
Effects of a mixture of medetomidine, midazolam and, fentanyl on glioma cell calcium activity. Video 7: . Calcium activity of ... Activity significantly decreases under deep anesthesia with a mixture of medetomidine, midazolam, and fentanyl (second half; n= ... medetomidine and fentanyl compared with control (minimal dose anaesthesia) conditions (n = 154 cells per group in 3 S24 PDX ...
Wiley: HPLC Methods for Recently Approved Pharmaceuticals - George Lunn
Acknowledgements. About This Book.. Abacavir.. Acarbose.. Acetyl sulfisoxazole.. Acrivastine.. Adapalene.. Adefovir dipivoxil.. Adrenocorticotropic hormone.. Afloqualone.. Alacepril.. Alclometasone 17,21-dipropionate.. Alitretinoin.. Allethrin.. Almotriptan.. Alosetron.. Amcinonide.. Aminolevulinic acid.. Amprenavir.. Anagrelide.. Anakinra.. Apraclonidine.. Aprepitant.. Aranidipine.. Arotinolol.. Arteether.. Articaine.. Asparaginase.. Atazanavir sulfate.. Atipamezole.. Atomoxetine hydrochloride.. Atorvastatin.. Atosiban.. Balofloxacin.. Bambermycins.. Befunolol.. Benzalkonium chloride.. Betaine.. Bethanechol chloride.. Bexarotene.. Biapenem.. Bimatoprost.. Bioresmethrin.. Bivalirudin.. Boldenone.. Bosentan.. β-Boswellic acid.. Brimonidine.. Bromfenac.. Brovincamine.. Bucillamine.. Budipine.. Bulaquine.. Butacaine.. Butamben.. Butoconazole.. Butyl flufenamate.. Cambendazole.. Candesartan cilexetil.. Capecitabine.. Casanthranol.. Caspofungin.. Castor ...
Dex,medetomidine for maintaining Hypotensive Anaesthesia in middle ear surgeries | International Journal of Current Research
Outflow of cerebrospinal fluid is predominantly through lymphatic vessels and is reduced in aged mice | Nature Communications
AnesthesiaDexmedetomidineAtipamezoleHydrochloridePropofolXylazine or MedetomidinePremedicationButorphanolMidazolam and fentanylIsofluraneAlpha2-adrenoceptorConstant rate infusionAlpha 2-adrenoceptorCompared with xylazineAnalgesiaAgonist medetomidineRate infusionsClinicalIntramuscularDogs0.05AdrenergicSedationAgonistsDoseCombinationsInfusionCombinationSignificantlyAnestheticEffectsEnantiomerLidocaineIntraperitoneal injectionPotentAlfaxaloneIntravenouslyPeripheralReindeerAdministrationSerumRatsDosage
Anesthesia12
- In veterinary anesthesia, medetomidine is often used in combinations with opioids (butorphanol, buprenorphine etc.) as premedication (before a general anesthetic) in healthy cats and dogs. (wikipedia.org)
- Effects of serial anesthesia using ketamine or ketamine/ medetomidine on hematology and serum biochemistry values in rhesus macaques (Macaca mulatto). (thefreedictionary.com)
- Medetomidine-ketamine anesthesia was antagonized with atipamezole (245.3 ± 63.4 μg/kg). (bioone.org)
- Timothy J. Portas , Michael J. Lynch , and Larry Vogelnest "COMPARISON OF ETORPHINE-DETOMIDINE AND MEDETOMIDINE-KETAMINE ANESTHESIA IN CAPTIVE ADDAX ( ADDAX NASOMACULATUS )," Journal of Zoo and Wildlife Medicine 34(3), 269-273, (1 September 2003). (bioone.org)
- Anesthesia was induced with diazepam and ketamine and Show more OBJECTIVE: To compare the effect of xylazine bolus versus medetomidine constant rate infusion (MCRI) on serum cortisol and glucose concentrations, urine production, and anesthetic recovery characteristics in dorsally recumbent, spontaneously breathing, isoflurane-anesthetized horses. (islandscholar.ca)
- For the MCRI treatment, end-tidal isoflurane concentration was maintained at 1.4% and medetomidine (0.005 mg/kg/h [0.0023 mg/lb/h], IV) was infused throughout anesthesia. (islandscholar.ca)
- The aim of this study was to compare the effects of propofol + sevoflurane, midazolam + sevoflurane, medetomidine + ketamine + sevoflurane anesthetic combinations on IOP, and to find out suitable anesthesia protocol in rabbits for ophthalmic surgery. (erciyes.edu.tr)
- To produce reliable anesthesia for MK, medetomidine was administered at 0.22 mg/kg (±SD = 0.05) and ketamine at 2.54 mg/kg (±0.56), and for MKB, medetomidine was administered at 0.12 mg/kg (±0.05), ketamine at 2.3 mg/kg (±0.39), and butorphanol at 0.05 mg/kg (±0.02). (edu.au)
- Blood Collection & Restraint sub-carapacial sinus Anesthesia Ketamine hydrochloride at a dose of 5-10 mg/kg combined with medetomidine at 50 mcg/kg IM works very well. (prezi.com)
- The predilection for delayed morbidity and mortality in males after anesthesia suggests that anesthesia with 0.5 mg/kg medetomidine and 50 mg/kg ketamine is a potential risk factor for obstructive uropathy due to release of seminal coagulum. (ingentaconnect.com)
- Highly concentrated alpha-2 agonists such as medetomidine commonly used in veterinary anesthesia, can potentially cause signific-ant harm or death if accidentally exposed to a human. (ispub.com)
- After administration of medetomidine anesthesia, the investigators performed similar evaluations of the reindeer nasal mucosa. (go.com)
Dexmedetomidine20
- Clinicophysiological and haemodynamic effects of fentanyl with xylazine, medetomidine and dexmedetomidine in isoflurane-anaesthetised water buffaloes (Bubalusbubalis). (thefreedictionary.com)
- Medetomidine and dexmedetomidine: a review of cardiovascular effects and antinociceptive properties in the dog. (thefreedictionary.com)
- 2) To institute EEG recordings after low dose medetomidine or dexmedetomidine as a standard of practice if focal abnormalities and amplitudes were not significantly altered by pharmaceuticals in Phase 1 of this study. (scirp.org)
- In the second phase of this study, the same dose of medetomidine or dexmedetomidine at 1 μg/kg IV and atipamezole (10 μg/kg, IM) were used in the evaluation of 20 clinical patients with suspected neurologic disease. (scirp.org)
- Administration of low dose medetomidine or dexmedetomidine followed by atipamezole reliably reduced the impact of movement artifacts and produced clinically valid EEG recordings in dogs. (scirp.org)
- L. Tepper and A. Shores, "Electroencephalographic Recordings in the Canine: Effects of Low Dose Medetomidine or Dexmedetomidine Followed by Atipamezole," Open Journal of Veterinary Medicine , Vol. 4 No. 2, 2014, pp. 7-13. (scirp.org)
- Guzel O., Kaya D.A., Altunatmaz K., Sevim G., Sezer D., Erdikmen D.O. (2018): Evaluation of the cardiorespiratory effects of the alpha-2 adrenoceptor agonists xylazine, medetomidine and dexmedetomidine in combination with ketamine in dogs. (agriculturejournals.cz)
- In this study, we compared the effects of xylazine, medetomidine and dexmedetomidine in combination with ketamine on heart rate, respiratory rate, blood gas values, temperature and sedation scores. (agriculturejournals.cz)
- An increase was observed in venous partial pressure of carbon dioxide values at T 2 in the xylazine/ketamine group compared to the medetomidine/ketamine and dexmedetomidine/ketamine groups. (agriculturejournals.cz)
- It was determined that none of α 2 -agonists, namely xylazine, medetomidine or dexmedetomidine, had superior properties over the others. (agriculturejournals.cz)
- In recent surveys of anaesthetic mortality in the dog however, premedication with medetomidine prior to anaesthesia for routine surgery, was not identified as an increased risk factor for mortality 17 and data from human literature has shown that dexmedetomidine is associated with a reduction in all causes of mortality when used for non-cardiac, cardiac and vascular surgery 18,19 . (vetlink.co.za)
- Medetomidine-ketamine (MK) and dexmedetomidine-ketamine (DK) are widely used to provide general anaesthesia in laboratory animals, but have not been compared directly in many of these species, including rodents. (strath.ac.uk)
- This study failed to demonstrate clinical advantages of the enantiomer dexmedetomidine over medetomidine when combined with ketamine to produce general anaesthesia in mice. (strath.ac.uk)
- REVERTIDINE is indicated for the reversal of the sedative and analgesic effects of dexmedetomidine hydrochloride, and medetomidine hydrochloride in dogs. (drugs.com)
- REVERTIDINE is administered intramuscularly (IM) for reversal of sedation and analgesia regardless of the route used for dexmedetomidine or medetomidine. (drugs.com)
- The atipamezole dose for the reversal of IV dexmedetomidine or medetomidine is 3750 mcg/m 2 . (drugs.com)
- Since atipamezole is always used concomitantly with dexmedetomidine or medetomidine, it should not be used in dogs with the following conditions: cardiac disease, respiratory disorders, liver or kidney diseases, dogs in shock, severely debilitated dogs, or dogs stressed due to extreme heat, cold or fatigue. (drugs.com)
- Selected examples are: Clonidine (mixed alpha2-adrenergic and imidazoline-I1 receptor agonist) Dexmedetomidine Fadolmidine Guanfacine, (preference for alpha2A-subtype of adrenoceptor) Guanabenz (most selective agonist for alpha2-adrenergic as opposed to imidazoline-I1) Guanoxabenz (metabolite of guanabenz) Guanethidine (peripheral alpha2-receptor agonist) Xylazine, Tizanidine Medetomidine Methyldopa Methylnorepinephrine Norepinephrine (R)-3-nitrobiphenyline is an α2C selective agonist as well as being a weak antagonist at the α2A and α2B subtypes. (wikipedia.org)
- Clinical comparison of preanaesthetic intramuscular medetomidine and dexmedetomidine in domestic sheep. (thefreedictionary.com)
- Accidental overdose (OD) with an alpha-2 agonist (a2a), such as dexmedetomidine (DEX) medetomidine (MED), or clonidine can potentially be life-threatening. (ispub.com)
Atipamezole10
- Each dog had an awake, baseline recording followed by an EEG performed after administration of low dose medetomidine (2 μg/kg IV) then atipamezole (10 μg/kg, IM). (scirp.org)
- After medetomidine and atipamezole, EEG waveforms were slower. (scirp.org)
- Immobilization of Norwegian reindeer (Rangifer tarandus tarandus) and Svalbard Reindeer (R. t. platyrhynchus) with medetomidine and medetomidine-ketamine and reversal of immobilization with atipamezole. (nih.gov)
- Atipamezole successfully antagonized medetomidine (-ketamine) resulting in rapid and persistent reversal of immobilization in all cases (NR and SR). Both medetomidine and atipamezole had wide safety margins and no conspicuous lasting side effects after reversal. (nih.gov)
- All dogs had tear readings taken presedation, 15 min postsedation, and 15 min after reversal of medetomidine with atipamezole. (nih.gov)
- Immobilization of captive nubian ibex (capra nubiana) with butorphanol-midazolam-medetomidine or butorphanol-azaperone-medetomidine and atipamezole reversal. (wizdom.ai)
- This study aimed at investigating and comparing the effects of medetomidine and atipamezole on the seminal variables of collared peccaries undergoing electroejaculation as well as at determining whether these drugs affected the erectile and ejaculatory functions of this species. (biomedcentral.com)
- When collared peccaries were anesthetized with propofol, neither medetomidine nor atipamezole significantly affected the characteristics of the semen or the erectile function, despite the fact that the AP treatment increased ejaculation time. (biomedcentral.com)
- Pre-anesthetic drugs, such as medetomidine and atipamezole, are used in anesthetic protocols in different domestic and wild species due to their excellent sedative effects. (biomedcentral.com)
- The medetomidine is then reversed with atipamezole. (prezi.com)
Hydrochloride10
- It is often used as the hydrochloride salt, medetomidine hydrochloride, a crystalline white solid. (wikipedia.org)
- Imalgene, Italy) plus medetomidine hydrochloride at 0. (thefreedictionary.com)
- This product has been withdrawn from sale and is superseded by Medetomidine hydrochloride (Cat. (tocris.com)
- Currently there are no citations for Medetomidine hydrochloride. (tocris.com)
- Be the first to review Medetomidine hydrochloride and earn rewards! (tocris.com)
- Have you used Medetomidine hydrochloride? (tocris.com)
- Six healthy, adult female cats were administered 0.2 mg/kg morphine sulphate, 60 microg/kg medetomidine hydrochloride, and 5 mg/kg ketamine hydrochloride intramuscularly. (biomedsearch.com)
- Nws yog siv raws li cov hydrochloride ntsev, medetomidine hydrochloride, crystalline dawb khoom. (ok-biotech.com)
- The anaesthetic protocol used in the current study included the alpha-2-adrenergic agonist medetomidine hydrochloride (Domitor®, Zoetis Animal Health, Sandton, South Africa) at 7 µg/kg iv as a premedicant, followed one minute later by propofol (Fresenius propoven®1%, Fresenius Kabi, Midrand, South Africa) at 1 to 2 mg/kg iv as an induction agent. (vetlink.co.za)
- CEPETOR™ (medetomidine hydrochloride) is a synthetic α2-adrenoreceptor agonist with sedative and analgesic properties. (drugs.com)
Propofol6
- Combinations of medetomidine with either propofol or ketamine were compared for the sedation and induction of anaesthesia in dogs undergoing a variety of surgical (60 per cent) and non.surgical (40 per cent) procedures. (bmj.com)
- Medetomidine was administered intramuscularly at a dose of 1000 μg/m 2 body surface area 10 to 15 minutes before the induction of anaesthesia by the administration of propofol (n = 44) or ketamine (n = 40) dosed to effect. (bmj.com)
- This study assessed puppy vigour and survival following medetomidine, propofol and sevoflurane anaesthesia for elective CS. (vetlink.co.za)
- The duration of action and cardiopulmonary effects of propofol (6.55 mg/kg intravenously), xylazine (0.8 mg/kg intramuscularly), medetomidine (30 micrograms/kg intramuscularly), xylazine plus propofol (3 mg/kg intravenously) and medetomidine plus propofol (3 mg/kg intravenously) were compared in dogs. (edu.au)
- Xylazine and medetomidine premedication prolonged propofol anaesthesia in dogs. (edu.au)
- The apnoea and hypoxaemia induced by propofol alone also occurred in the premedicated groups with hypoxaemia being most evident in the medetomidine/propofol group. (edu.au)
Xylazine or Medetomidine3
- The Effect of Tiletamine/Zolazepam (Zoletile) Combination with Xylazine or Medetomidine on Electroencephalograms in Dogs," The Journal of Veterinary Medical Science, Vol. 66, No. 5, 2004, pp. 501-507. (scirp.org)
- Bradycardia was a common feature in all the dogs given xylazine or medetomidine, but hypertension was consistently recorded in all the dogs given medetomidine. (edu.au)
- PROCEDURES: Horses were premedicated with xylazine or medetomidine IV. (islandscholar.ca)
Premedication3
- When used for premedication, medetomidine will significantly reduce the dose of all other anesthetic agents. (vetstream.com)
- CONCLUSIONS AND CLINICAL RELEVANCE: In isoflurane-anesthetized horses, premedication and administration of medetomidine as a constant rate infusion resulted in decreased serum cortisol concentration, increased serum glucose concentration, and superior anesthetic recovery characteristics, compared with conventional treatment with xylazine. (islandscholar.ca)
- Medetomidine (MED) group was administered 20 mcg/ kg of iv MED for premedication. (bvsalud.org)
Butorphanol6
- Horses were premedicated with acepromazine, romifidine and butorphanol, induced with guaifenesin and ketamine and maintained on a constant rate infusion of lidocaine, ketamine and medetomidine together with halothane inhalation anaesthesia. (scielo.org.za)
- Medetomidine is a commonly used sedative in veterinary medicine whether administered alone or in combination with an opioid such as butorphanol. (nih.gov)
- The present study looked at two groups of 10 dogs each that were sedated with intravenous medetomidine or a combination of medetomidine and butorphanol. (nih.gov)
- Results revealed that intravenous sedation with medetomidine and medetomidine-butorphanol in dogs with no history of ophthalmic disease and presedation STT 1 readings above 15 mm/min, causes a significant decrease in tear production that is measurable at 15 min postsedation. (nih.gov)
- The effects of intramuscularly administered medetomidine and butorphanol (MB), and medetomidine, butorphanol, atropine (MBA) on glomerular filtration rate (GFR) were determined in six dogs as measured by 99m-Tc-labeled diethylenetriaminepentaacetic acid (99mTc-DTPA) nuclear scintigraphy. (avmi.net)
- The results of this study indicate that the administration of medetomidine in combination with butorphanol significantly increases total GFR in healthy dogs, while the administration of the combination of medetomidine, butorphanol, and atropine does not. (avmi.net)
Midazolam and fentanyl1
- We therefore compared inhalational anaesthesia using isoflurane (ISO), with an intramuscular (i.m.) combination of ketamine and xylazine (KX) as well as a completely antagonizable anaesthesia using the combination of medetomidine, midazolam and fentanyl (MMF) administered i.m. in adult male Wistar rats instrumented for the continuous, telemetric collection of cardiovascular parameters. (beds.ac.uk)
Isoflurane2
- OBJECTIVE: To compare the effect of xylazine bolus versus medetomidine constant rate infusion (MCRI) on serum cortisol and glucose concentrations, urine production, and anesthetic recovery characteristics in dorsally recumbent, spontaneously breathing, isoflurane-anesthetized horses. (islandscholar.ca)
- This study investigated effects on cardiovascular parameters during anaesthesia with isoflurane (ISO, 2-3 Vol%), ketamine-xylazine (KX, 100 mg kg -1 + 5 mg kg -1 ) or a combination of medetomidine-midazolam-fentanyl (MMF, 0.15 mg kg -1 + 2.0 mg kg -1 + 0.005 mg kg -1 ) in rats throughout induction, maintenance and recovery from anaesthesia. (beds.ac.uk)
Alpha2-adrenoceptor1
- His thesis was in "A study on medetomidine an Alpha2 Adrenoceptor agent alone and in combination with other Anaesthetics on different animals. (thefreedictionary.com)
Constant rate infusion1
- Medetomidine has also been used in combination with morphine (or methadone), lidocaine and ketamine in constant rate infusion analgesia in canines. (wikipedia.org)
Alpha 2-adrenoceptor1
- Characterisation of selectivity, specificity and potency of medetomidine as an alpha 2-adrenoceptor agonist. (thefreedictionary.com)
Compared with xylazine1
- Neurohormonal and metabolic effects of medetomidine compared with xylazine in beagle dogs. (semanticscholar.org)
Analgesia1
- Guedes, AG, Rude, EP & Kannan, MS 2013, ' Potential role of the CD38/cADPR signaling pathway as an underlying mechanism of the effects of medetomidine on insulin and glucose homeostasis ', Veterinary Anaesthesia and Analgesia , vol. 40, no. 5, pp. 512-516. (elsevier.com)
Agonist medetomidine1
- Conclusion: The CD38/cADPR signaling pathway may be one underlying mechanism of the glucose and insulin effects of the alpha-2 adrenergic receptor agonist medetomidine and likely other drugs of its' class. (elsevier.com)
Rate infusions1
- Carter Jennifer E, Campbell Nigel B, Posner Lysa P, Swanson Cliff (2010): The hemodynamic effects of medetomidine continuous rate infusions in the dog. (agriculturejournals.cz)
Clinical2
- Effects of different doses of medetomidine on clinical hematological parameters in dogs. (thefreedictionary.com)
- Xylazine and medetomidine showed a similar pharmacodynamic behavior but with different clinical aspects. (bvsalud.org)
Intramuscular1
- Anaesthetic and cardiopulmonary effects of intramuscular morphine, medetomidine and ketamine administered to telemetered cats. (biomedsearch.com)
Dogs5
- Effect of Medetomidine on Electroencephalography and Use of a Quantitative Electroencephalograph for Evaluating Sedation Levels in Dogs," Journal of Veterinary Medicine Series A, Vol. 48, No. 9, 2001, pp. 525-535. (scirp.org)
- The dogs became sedated by medetomidine after a mean (sd) time of 6.7 (5.4) minutes, and their heart rates and respiration rates decreased. (bmj.com)
- This study was aimed to investigate and compare the effects of medetomidine and xylazine on the blood level of some stress-related neurohormonal and metabolic variables in clinically normal dogs, especially focusing on time and dose relations of the effects. (semanticscholar.org)
- The pharmacological restraint and pain relief provided by medetomidine facilitates handling dogs and aids in the conduct of diagnostic or therapeutic procedures. (drugs.com)
- Spontaneous muscle contractions (twitching) can be expected in some dogs sedated with medetomidine. (drugs.com)
0.051
- The aim of this study was testing a combination of tiletamine-zolazepam (TZ) (3 mg/kg) and medetomidine (M) (0.05 mg/kg) on Eurasian wild boar ( Sus scrofa ). (beds.ac.uk)
Adrenergic2
- The effects of medetomidine , an alpha 2-adrenergic agonist, on ventilatory drive in the dog. (thefreedictionary.com)
- Medetomidine, an α2 adrenergic agonist. (wikipedia.org)
Sedation1
- Profound sedation and recumbency, with reduced sensitivity to environmental stimuli (sounds, etc.), are seen with medetomidine. (drugs.com)
Agonists1
- The pharmacological response elicited by α2-agonists (e.g., medetomidine) in such animal is often reduced, with depth and duration of sedative/analgesic effects ranging from slightly diminished to nonexistent. (drugs.com)
Dose1
- When medetomidine was given at 3 and 5 times the recommended dose IV, and 5 and 10 times IM, effects were not intensified but were prolonged. (drugs.com)
Combinations1
- A combination of medetomidine and ketamine is currently considered a safe and reliable alternative to opioid combinations for captive giraffe, but is considered less than optimal for capture of free-ranging giraffe. (girafferesourcecentre.org)
Infusion1
- To compare, by continuous infusion of ketamine or medetomidine combined to methotrimeprazine and buprenorphine , ketamine and midazolam , the degree of hypnosis , myorelaxation, anesthetic quality and surgical feasibility through evaluation of possible parametric alterations and recovery quality . (bvsalud.org)
Combination5
- A preliminary investigation into the immobilising potential of a tiletamine/zolazepam mixture, metomidate, a metomidate and azaperone combination and medetomidine in ostriches (Struthio camelus). (thefreedictionary.com)
- Thirty-five anesthetic events involving 15 captive addax ( Addax nasomaculatus ) were performed between August 1998 and February 2002 using a combination of etorphine (33.7 ± 7.9 μg/kg) and detomidine (21.9 ± 4.6 μg/kg) or a combination of medetomidine (57.4 ± 8.6 μg/kg) and ketamine (1.22 ± 0.3 μg/kg), with or without supplemental injectable or inhalant anesthetic agents. (bioone.org)
- Animals became recumbent within 5 min when the combination of etorphine and detomidine was used and within 11 min when the combination of medetomidine and ketamine was used. (bioone.org)
- The quality and duration of anaesthesia, cardiorespiratory effects and recovery characteristics of a morphine, medetomidine, ketamine (MMK) drug combination were determined in cats. (biomedsearch.com)
- Giral M, Garcia-Olmo D V, Gomez-Juarez M et al (2014) Anaesthetic effects in the ferret of alfaxalone alone and in combination with medetomidine or tramadol: a pilot study . (vetstream.com)
Significantly1
- Correspondingly, medetomidine caused a significantly greater increase in plasma glucose concentrations in the WT than in the CD38 -/- mice. (elsevier.com)
Anesthetic1
- Medetomidine is a synthetic drug used as both a surgical anesthetic and analgesic. (wikipedia.org)
Effects5
- Scheinin et al (1989) Medetomidine - a novel α 2 -adrenoceptor agonist: a review of its pharmacodynamic effects. (tocris.com)
- Schernthaner A, Lendl C E, Hartmann K et al (2011) Medetomidine/midazolam/ketamine anaesthesia in ferrets: effects on cardiorespiratory parameters and evaluation of plasma drug concentrations . (vetstream.com)
- Objective: To investigate the CD38/cADPR signaling pathway as possible underlying mechanism of the effects of medetomidine on insulin and glucose homeostasis. (elsevier.com)
- As part of a thorough ecotoxicological evaluation of medetomidine, its short-term effects on algal and bacterial communities were investigated and environmental concentrations were predicted with the MAMPEC model. (chalmers.se)
- It is concluded that medetomidine does not cause any acute toxic effects on bacterial protein synthesis and only small acute effects on photosynthesis at high concentrations in marine microbial communities. (chalmers.se)
Enantiomer1
- Active enantiomer of medetomidine ( ab120787 ). (abcam.com)
Lidocaine1
- Mean dobutamine requirement to maintain mean arterial pressure above 9.31 kPa was 0.42 ± 0.3 µg/kg/min The administration of relatively low doses of lidocaine, ketamine and medetomidine together with halothane resulted in haemodynamically stable anaesthesia, followed by smooth recovery. (scielo.org.za)
Intraperitoneal injection1
- Male and female mice were anesthetized by intraperitoneal injection with a mixture delivering 0.5 mg/kg medetomidine and 50 mg/kg ketamine to achieve immobilization for whole-body radiographs and bone densitometry, as part of a phenotypic screen for bone and mineral disorders in mice carrying genetic modifications induced through mutagenesis with N ′-ethyl- N ′-nitrosourea. (ingentaconnect.com)
Potent1
- Savola et al (1986) Evidence for medetomidine as a selective and potent agonist at alpha 2-adrenoceptors. (tocris.com)
Alfaxalone1
- Field immobilization using alfaxalone and alfaxalone-medetomidine in free-ranging koalas (Phascolarctos cinereus): a randomized comparative study. (koalahealthhub.org.au)
Intravenously1
- The second group, the medetomidine/ketamine group, intravenously received medetomidine (10 µg/kg) followed by ketamine (5 mg/kg). (agriculturejournals.cz)
Peripheral1
- With medetomidine administration, blood pressure is initially increased due to peripheral vasoconstriction and thereafter drops to normal or slightly below-normal levels. (drugs.com)
Reindeer1
- Immobilization of Norwegian reindeer (Rangifer tarandus tarandus) and Svalbard Reindeer (R. t. platyrhynchus) with medetomidine and medetomidine-ke. (nih.gov)
Administration1
- As compared to controls, medetomidine administration produced a statistically significant decrease in plasma insulin concentrations in the WT mice whereas the decrease in the CD38 -/- mice was not statistically significant. (elsevier.com)
Serum1
- Accuracy, precision, and specificity were evaluated and the method was determined to be applicable to detection of medetomidine, xylazine, ketamine, and acepromazine in serum samples of multiple animal species (canine, equine, and bovine). (elsevier.com)
Rats1
- We investigated the potential of such systems in functional MR imaging (fMRI) of somatosensory cortex activity elicited by forepaw stimulation in medetomidine-sedated rats. (fujita-hu.ac.jp)
Dosage1
- The dosage form available for Medetomidine is Injection Solution. (wedgewoodpharmacy.com)