A histamine H1 antagonist used in the treatment of motion sickness, vertigo, and nausea during pregnancy and radiation sickness.
A plant family of the order Caryophyllales, subclass Caryophyllidae, class Magnoliopsida. Some members contain triterpenoid saponins.
That segment of commercial enterprise devoted to the design, development, and manufacture of chemical products for use in the diagnosis and treatment of disease, disability, or other dysfunction, or to improve function.
A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Caffeine's most notable pharmacological effect is as a central nervous system stimulant, increasing alertness and producing agitation. It also relaxes SMOOTH MUSCLE, stimulates CARDIAC MUSCLE, stimulates DIURESIS, and appears to be useful in the treatment of some types of headache. Several cellular actions of caffeine have been observed, but it is not entirely clear how each contributes to its pharmacological profile. Among the most important are inhibition of cyclic nucleotide PHOSPHODIESTERASES, antagonism of ADENOSINE RECEPTORS, and modulation of intracellular calcium handling.
A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935)
It is a form of protection provided by law. In the United States this protection is granted to authors of original works of authorship, including literary, dramatic, musical, artistic, and certain other intellectual works. This protection is available to both published and unpublished works. (from Circular of the United States Copyright Office, 6/30/2008)
The giving of drugs, chemicals, or other substances by mouth.
Disorder caused by motion, as sea sickness, train sickness, car sickness, air sickness, or SPACE MOTION SICKNESS. It may include nausea, vomiting and dizziness.
An illusion of movement, either of the external world revolving around the individual or of the individual revolving in space. Vertigo may be associated with disorders of the inner ear (EAR, INNER); VESTIBULAR NERVE; BRAINSTEM; or CEREBRAL CORTEX. Lesions in the TEMPORAL LOBE and PARIETAL LOBE may be associated with FOCAL SEIZURES that may feature vertigo as an ictal manifestation. (From Adams et al., Principles of Neurology, 6th ed, pp300-1)

Vertigo - part 2 - management in general practice. (1/8)

BACKGROUND: Vertigo is a common clinical problem managed by general practitioners. OBJECTIVE: This article focuses on the acute management of a vertigo attack, specific management of conditions causing vertigo, and the long term management issues associated with chronic vertigo. DISCUSSION: Supportive treatment, antiemetic and vestibular blocking agents help relieve an acute vertigo attack, however the prolonged use of such medications is not recommended. Specific treatments for various conditions causing vertigo are available, however, the majority of patients are managed symptomatically. The patient's ability to drive safely should be carefully assessed according to Austroads guidelines and advice from an ear, nose and throat surgeon should be sought when in doubt. There is evidence to support the efficacy of vestibular rehabilitation programs for unilateral peripheral vestibular disorder and these programs should be considered. A simple program including patient education and home based exercises can be sufficient.  (+info)

Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis. (2/8)

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Meclizine is neuroprotective in models of Huntington's disease. (3/8)

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Differential effect of meclizine on the activity of human pregnane X receptor and constitutive androstane receptor. (4/8)

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Helix 11 dynamics is critical for constitutive androstane receptor activity. (5/8)

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Activation of a PGC-1-related coactivator (PRC)-dependent inflammatory stress program linked to apoptosis and premature senescence. (6/8)

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Neutrophil-infiltrated paw edema induced by mannose-binding Dioclea violacea lectin. (7/8)

BACKGROUND: The potential edematogenic effect and the pharmacological characterization of a glucose-mannose-binding lectin from Dioclea violacea (DvL) were investigated. METHODS: Paw edema was induced with DvL in control animals, and in animals pretreated with glucocorticoid or with blockers of histamine, nitric oxide synthase, cyclooxygenase, platelet activating factor (PAF), bradykinin and lipoxygenase. RESULTS: DvL-induced paw edema paralleled with an increase in vascular permeability and myeloperoxidase (MPO) activity. DvL-induced edema could be prevented by pre-treatment with the lectin-binding sugar alpha-D-methyl mannoside. Dexamethasone, meclizine and Nomega-nitro-L-arginine methyl ester hydrochloride (L-NAME) inhibited this effect. CONCLUSIONS: DvL induces edema, increase in vascular permeability and neutrophil infiltration. The edematogenic activity involves the lectin mannose-binding sites and is associated with histamine, cytokines and nitric oxide, since it could be treated with meclizine, dexamethasone and L-NAME.  (+info)

Meclizine inhibits mitochondrial respiration through direct targeting of cytosolic phosphoethanolamine metabolism. (8/8)

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Desmond (2015) reports that Meclizine (aka Antivert, Nonine, and Dramamine II) is an antihistamine with antiemetic and anti-cholinergic properties (i.e., anticholinergics tend to block the transmission of acetylcholine in the PNS and CNS). MedicineNet.com reports that Meclizine is an antihistamine with antiemetic and antispasmodic activity. It suppresses the nervous system by blocking the action of the neurotransmitter acetylcholine. Meclizine prevents nausea and vomiting by reducing the activity of the center in the brain that controls nausea. It also prevents motion sickness by reducing excitability of neurons in the motion and balance center (vestibular region) of the brain. The FDA approved Meclizine in February 1957.. Desmond states that Meclizine has been prescribed often for patients with complaints of vertigo and/or dizziness. Further, he states, For a medication that is so widely used, there is very little solid information, creating potential for confusion regarding application and ...
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Your mouth may get dry. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Take your doses at regular intervals. Investigators hypothesize that reversing CAR function with meclizine will have a beneficial therapeutic effect in patients with HCC by blocking proliferation and inducing apoptosis. Meclizine can create or worsen problems for some Meclizine. In HCC it has been used for anti-emetic effects, but it is used here as a CAR constitutive androstane receptor inverse agonist. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Estimated Study Completion Date :. Take this medicine only as directed by your doctor. Jump to content. Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated. Although not all of these side effects may occur, if they do occur they may ...
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Use this medication exactly as prescribed by your doctor. Do not use it in larger amounts or for longer than recommended. Take Meclizine with a full glass of water. To prevent motion sickness, take the dose of 25 to 50 mg about 1 hour before you travel or engage in activity that causes motion sickness. To treat vertigo, you may need to take Meclizine several times daily. The recommended dose is 25 to 100 mg daily, in divided dosage ...
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A number of medications may cause meclizine drug interactions, including pramlintide, anticholinergic drugs, and phenothiazine medicines. Emesafene is a combination of meclizine (1/3) and pyridoxine (2/3). Its been 48 hrs. Can phenergan be taken with tramadol. It is also an antitu. Check with your doctor or pharmacist for other options Jul 26, 2010 · Yes, a person can take Ritalin and Meclizine together. Be careful when sitting or standing. Therefore, it should not be used in children less than 2 years old. The typo has been mild, but might jerks the relative. Take it step by step. Best choice. Visit cvs.com …. I …. Since it is chewable, I find relief within 5 minutes and can function once again. They all come with some side effects as well, which can include dry mouth and blurred vision Phenergan Drug Interactions If pramlintide, anticholinergic drugs, or monoamine oxidase inhibitors are taken together with Phenergan, drug interactions may occur. They can be taken together. Have you had a ...
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Long term effects of meclizine - How long does meclizine stay in the system? Depends. The onset of action is ~1 hour; the duration of action is ~24 hours. The time to eliminate 1/2 of the dose is 5 hours (half-life elimination). Source: wang z, lee b, pearce d, et al, meclizine metabolism and pharmacokinetics: formulation on its absorption, j clin pharmacol, 2011a, [epub ahead of print] [pubmed 21903894].
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National Drug Codes Number: 66267-138-60. Drug Non Proprietary Name: Meclizine Hydrochloride. Drug Trade Name: Meclizine Hydrochloride.
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Meclizine: A histamine H1 antagonist used in the treatment of motion sickness, vertigo, and nausea during pregnancy and radiation sickness.
What kind of pill is football in shape, yellow in color and has the imprint TL 121? The KGB Agent answer: An oval yellow pill with the imprint TL 121 on the front is 25mg of Meclizine (made by Cadista). Meclizine is a anticholinergic antiemetic that is used to treat vertigo, motion sickness, and nausea/vomiting (in simple terms, Meclizine is an antihistamine that reduces the effects of histamine in the body). Meclizine, is also sold as Sea Legs, Postafen, Dramamine, Antivert, Bonamine, and Bonine. There is a low risk of abuse with this drug. This medication is not proven to be a risk to an unborn fetus. MedicineNet offers some tips on antihistamines. MedicineNewsToday is reporting that antihistamines may actually help fight cancer!
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If you ever decide to come to New Zealand, you must must must take a cruise down the Doubtful Sound. It is absolutely incredible. One problem, it is not for the weak at sea...like me. I inquired about the roughness of the cruise before I bought the tickets and the girl said that its basically smooth until you got out to sea, where it can get a little rough. You will stay out there for about 20 minutes. For those of you who get seasick, ask your doctor to prescribe you some Meclizine. If you are one that is prone to getting seasick then this will be your best friend. I am EXTREMELY sensitive and so far Ive had to use it about 4 times and never had a problem ...
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Meclizine is an antihistamine and anticholinergic which is used to treat or prevent nausea, vomiting and dizziness. | Discountab.com
All medicines may cause side effects, but many people have no, or minor, side effects.. Check with your doctor if any of these most common side effects persist or become bothersome:. Drowsiness; dry mouth.. Seek medical attention right away if any of these severe side effects occur:. Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue ...
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Not all of the side effects listed above have been reported for each of these medicines, but they have been reported for at least one of them. Buclizine, cyclizine, and meclizine are similar, so any of the above side effects may occur with any of these medicines.. Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.. Portions of this document last updated: March 01, 2017. Original article: http://www.mayoclinic.org/drugs-supplements/meclizine-buclizine-and-cyclizine-oral-route-parenteral-route/description/drg-20069630. Copyright © 2017 Truven Health Analytics Inc. All rights reserved. Information is for End Users use only and may not be sold, redistributed or otherwise used for commercial purposes.. ...
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Meclizine is an antiemetic used in the treatment of motion sickness. Brand names include Antivert, Bonine, Bonamine, Dizmiss, Meni-D, and Ru-Vert-M.
Meclizine (Bonine, Antivert). *Promethazine (Pentazine, Phenergan, Promacot) can be administered via a rectal suppository, ...
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Commercially available motion-sickness agents including cinnarizine and meclizine are derivatives of benzylamine. 1- ...
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Meclizine (most commonly used as an antiemetic). *Mirtazapine (primarily used to treat depression, also has antiemetic and ...
... meclizine MeSH D03.383.606.760 --- pipecuronium MeSH D03.383.606.765 --- pipemidic acid MeSH D03.383.606.773 --- pipobroman ...
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The hormone prolactin stimulates lactation (production of breast milk). Dopamine, released by the hypothalamus stops the release of prolactin from the pituitary gland. Domperidone, by acting as an anti-dopaminergic agent, results in increased prolactin secretion, and thus promotes lactation (that is, it is a galactogogue). In some nations, including Australia, domperidone is used off-label, based on uncertain and anecdotal evidence of its usefulness, as a therapy for mothers who are having difficulty breastfeeding.[24][25] In the United States, domperidone is not approved for this or any other use.[26][27] A study called the EMPOWER trial was designed to assess the effectiveness and safety of domperidone in assisting mothers of preterm babies to supply breast milk for their infants.[28] The study randomized 90 mothers of preterm babies to receive either domperidone 10 mg orally three times daily for 28 days (Group A) or placebo 10 mg orally three times daily for 14 days followed by domperidone ...
... is a low cost drug.[7] In the United States, Salix Pharmaceuticals holds a US Patent for rifaximin and markets the drug under the name Xifaxan.[17][18] In addition to receiving FDA approval for traveler's diarrhea and (marketing approved for)[18] hepatic encephalopathy, rifaximin received FDA approval for IBS in May 2015.[19] No generic formulation is available in the US and none has appeared due to the fact that the FDA approval process was ongoing. If rifaximin receives full FDA approval for hepatic encephalopathy it is likely that Salix will maintain marketing exclusivity and be protected from generic formulations until March 24, 2017.[18] Rifaximin is approved in 33 countries for GI disorders.[20][21] On August 13, 2013, Health Canada issued a Notice of Compliance to Salix Pharmaceuticals Inc. for the drug product Zaxine.[22] In India it is available under the brand names Ciboz and Xifapill.[citation needed] In Russia and Ukraine the drug is sold under the name Alfa Normix ...
Long-term use of methylprednisolone, as with all corticosteroids, can be associated with hyperglycemia, decreased resistance to infection, swelling of face, weight gain, congestive cardiac insufficiency, fluid and sodium retention, edema, hypertension, increased eye pressure, glaucoma, osteoporosis, and psychosis, especially when used at high doses.[11][12] The most serious side effect occurs after the adrenal glands cease natural production of cortisol, which methylprednisolone will replace. Abrupt cessation of the drug after this occurs can result in a condition known as Addisonian crisis, which can be fatal. To prevent this, the drug is usually prescribed with a tapering dose, including a predosed "dose pack" detailing a specific number of tablets to take at designated times over a several-day period. Pharmacists sometimes advise that this drug may cause sleeplessness and "down" moods. Measles and chicken pox are very dangerous and potentially fatal for people on methylprednisolone therapy. ...
Important drug interactions are rare.[27][28] However, the most significant major drug interaction concern is the decreased activation of clopidogrel when taken together with omeprazole.[29] Although still controversial,[30] this may increase the risk of stroke or heart attack in people taking clopidogrel to prevent these events. This interaction is possible because omeprazole is an inhibitor of the enzymes CYP2C19 and CYP3A4.[31] Clopidogrel is an inactive prodrug that partially depends on CYP2C19 for conversion to its active form. Inhibition of CYP2C19 may block the activation of clopidogrel, which could reduce its effects.[32][33] Almost all benzodiazepines are metabolised by the CYP3A4 and CYP2D6 pathways, and inhibition of these enzymes results in a higher AUC (i.e., the total effect over time of a given dose). Other examples of drugs dependent on CYP3A4 for their metabolism are escitalopram,[34] warfarin,[35] oxycodone, tramadol, and oxymorphone. The concentrations of these drugs may ...
Bonow RO, Carabello BA, Kanu C, et al. (August 2006). "ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (writing committee to revise the 1998 Guidelines for the Management of Patients With Valvular Heart Disease): developed in collaboration with the Society of Cardiovascular Anesthesiologists: endorsed by the Society for Cardiovascular Angiography and Interventions and the Society of Thoracic Surgeons". Circulation. 114 (5): e84-231. doi:10.1161/CIRCULATIONAHA.106.176857. PMID 16880336 ...
... has been investigated for use as a radiation countermeasure. Its value as a radiation countermeasure is based mainly on its stimulation of production of white blood cells and platelets.[6] Its potential use as a radiation countermeasure was developed by the Armed Forces Radiobiology Research Institute (AFRRI) and subsequently studied by AFRRI and Hollis-Eden Pharmaceuticals under the proposed brand name Neumune for the treatment of acute radiation syndrome.[6][7] The clinical trials with rhesus monkeys were successful. According to the Hollis-Eden report, only 12.5% of the 40 Neumune-treated animals died versus 32.5% in the placebo group.[8] Hollis-Eden had applied for a contract from the U.S. Government under the BioShield Request for Proposals (RFP) for radiation countermeasures. After being encouraged for 2.5 years that Neumune was in the competitive range, on March 9, 2007, the RFP was canceled by HHS. According to HHS, "the product was no longer in the competitive ...
... (CBZ), sold under the trade name Tegretol among others, is an anticonvulsant medication used primarily in the treatment of epilepsy and neuropathic pain.[1] It is not effective for absence or myoclonic seizures.[1] It is used in schizophrenia along with other medications and as a second-line agent in bipolar disorder.[3][1] Carbamazepine appears to work as well as phenytoin and valproate for focal and generalised seizures.[4] Common side effects include nausea and drowsiness.[1] Serious side effects may include skin rashes, decreased bone marrow function, suicidal thoughts, or confusion.[1] It should not be used in those with a history of bone marrow problems.[1] Use during pregnancy may cause harm to the baby; however, stopping the medication in pregnant women with seizures is not recommended.[1] Its use during breastfeeding is not recommended.[1] Care should be taken in those with either kidney or liver problems.[1] Carbamazepine was discovered in 1953 by Swiss chemist Walter ...
... is an allosteric endocannabinoid, as it is a negative allosteric modulator of the CB1 receptor.[4][5] Pregnenolone is involved in a natural negative feedback loop against CB1 receptor activation in animals.[6][better source needed] It prevents CB1 receptor agonists like tetrahydrocannabinol, the main active constituent in cannabis, from fully activating the CB1 [6][better source needed] Pregnenolone has been found to bind with high, nanomolar affinity to microtubule-associated protein 2 (MAP2) in the brain.[7][8] In contrast to pregnenolone, pregnenolone sulfate did not bind to microtubules.[7][8] However, progesterone did and with similar affinity to pregnenolone, although unlike pregnenolone, it did not increase binding of MAP2 to tubulin.[7][8] Pregnenolone was found to induce tubule polymerization in neuronal cultures and to increase neurite growth in PC12 cells treated with nerve growth factor.[7][8] As such, pregnenolone may control formation and stabilization of microtubules ...
... also binds to and blocks α2δ subunit-containing VDCCs, similarly to gabapentin and pregabalin, and hence is a gabapentinoid.[9][16] Both (R)-phenibut and (S)-phenibut display this action with similar affinity (Ki = 23 and 39 μM, respectively).[9] Moreover, (R)-phenibut possesses 4-fold greater affinity for this site than for the GABAB receptor (Ki = 92 μM), while (S)-phenibut does not bind significantly to the GABAB receptor (Ki , 1 mM).[9] As such, based on the results of this study, phenibut would appear to have much greater potency in its interactions with α2δ subunit-containing VDCCs than with the GABAB receptor (between 5- to 10-fold).[9] For this reason, the actions of phenibut as a α2δ subunit-containing voltage-gated calcium channel blocker or gabapentinoid may be its true primary mechanism of action, and this may explain the differences between phenibut and its close relative baclofen (which, in contrast, has essentially insignificant activity as a gabapentinoid; Ki = 6 ...
... has little systemic absorption, and is considered safe for topical use in adults and children over the age of 2 months. The FDA has assigned it as pregnancy category B. Animal studies have shown no effects on fertility or teratogenicity, but studies in humans have not been performed. The excretion of permethrin in breastmilk is unknown, and breastfeeding is recommended to be temporarily discontinued during treatment.[11] According to the Connecticut Department of Public Health, permethrin "has low mammalian toxicity, is poorly absorbed through the skin, and is rapidly inactivated by the body. Skin reactions have been uncommon."[14] Excessive exposure to permethrin can cause nausea, headache, muscle weakness, excessive salivation, shortness of breath, and seizures. Worker exposure to the chemical can be monitored by measurement of the urinary metabolites, while severe overdose may be confirmed by measurement of permethrin in serum or blood plasma.[15] Permethrin does not present any ...
where CL is total body clearance (L/h), BSA is total body surface area (m2), AAG and ALB represent alpha1 acid glycoprotein and albumin plasma concentrations (g/L) respectively, and AGE is the patients age (years).[13] HEP12 represents a measure of hepatic dysfunction, affecting clearance of docetaxel. This final model accounted for a modest proportion of patients and identified most of the patients varying from the model (population median of CL = 35.6 L/h) as having hepatic dysfunction, indicating hepatic function as the most unpredictable factor with regards to clearance variability.[13] Patients with significant hepatic dysfunction had an approximately 30% decrease in clearance of docetaxel and were also at a higher risk of toxicity poisoning from docetaxel treatment.[13] Clearance has been shown from population pharmacokinetic studies to decrease significantly with age, increased alpha1 acid glycoprotein and albumin concentrations and decreased body surface area.[13] Renal impairment is ...
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Pregnidoxin information about active ingredients, pharmaceutical forms and doses by UCB Pharma, Pregnidoxin indications, usages and related health products lists
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Naus-Ease® (Meclizine Hydrochloride), USP; 8 Tablets: NDC 49467-124-08. Naus-Ease® (Meclizine Hydrochloride), USP; 16 Tablets: ... The effect of hepatic impairment on the pharmacokinetics of meclizine has not been evaluated. As Meclizine Hydrochloride, USP ... NAUS-EASE- meclizine hydrochloride tablet To receive this label RSS feed. Copy the URL below and paste it into your RSS Reader ... Meclizine Hydrochloride, USP is an oral antiemetic, which is a white to slightly yellowish crystalline powder having a slight ...
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  • However, studies in animals have shown that buclizine, cyclizine, and meclizine given in doses many times the usual human dose cause birth defects, such as cleft palate. (mayoclinic.org)
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  • Meclizine is a first-generation antihistamine (nonselective H1 antagonist) of the piperazine class. (wikipedia.org)
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  • Do not give to children under 12 years of age unless directed by a doctor.Meclizine is also used to treat symptoms of vertigo (dizziness or spinning sensation) caused Be careful if you drive or do anything that requires you to be alert.Meclizine is an example of an antihistamine. (intelonetworks.com)
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  • Which drugs or supplements interact with meclizine? (medicinenet.com)
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  • Meclizine is also used to treat symptoms of vertigo (dizziness or spinning sensation) caused by disease that affects your inner ear. (rexhealth.com)
  • Meclizine is used for the prevention and treatment of the nausea , vomiting, and dizziness associated with motion sickness . (rxlist.com)
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  • Buclizine, cyclizine, and meclizine are used to prevent and treat nausea, vomiting, and dizziness associated with motion sickness, and vertigo (dizziness caused by other medical problems). (mayoclinic.org)
  • Claritin ( loratadine ) is used more for allergies and/or urticaria (itching), and Meclizine is used more often for dizziness /vertigo. (healthtap.com)
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