A syndrome characterized by progressive life-threatening RESPIRATORY INSUFFICIENCY in the absence of known LUNG DISEASES, usually following a systemic insult such as surgery or major TRAUMA.
A condition of the newborn marked by DYSPNEA with CYANOSIS, heralded by such prodromal signs as dilatation of the alae nasi, expiratory grunt, and retraction of the suprasternal notch or costal margins, mostly frequently occurring in premature infants, children of diabetic mothers, and infants delivered by cesarean section, and sometimes with no apparent predisposing cause.
Any method of artificial breathing that employs mechanical or non-mechanical means to force the air into and out of the lungs. Artificial respiration or ventilation is used in individuals who have stopped breathing or have RESPIRATORY INSUFFICIENCY to increase their intake of oxygen (O2) and excretion of carbon dioxide (CO2).
A method of mechanical ventilation in which pressure is maintained to increase the volume of gas remaining in the lungs at the end of expiration, thus reducing the shunting of blood through the lungs and improving gas exchange.
The volume of air inspired or expired during each normal, quiet respiratory cycle. Common abbreviations are TV or V with subscript T.
Substances and drugs that lower the SURFACE TENSION of the mucoid layer lining the PULMONARY ALVEOLI.
A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).
Ventilatory support system using frequencies from 60-900 cycles/min or more. Three types of systems have been distinguished on the basis of rates, volumes, and the system used. They are high frequency positive-pressure ventilation (HFPPV); HIGH-FREQUENCY JET VENTILATION; (HFJV); and high-frequency oscillation (HFO).
Techniques for effecting the transition of the respiratory-failure patient from mechanical ventilation to spontaneous ventilation, while meeting the criteria that tidal volume be above a given threshold (greater than 5 ml/kg), respiratory frequency be below a given count (less than 30 breaths/min), and oxygen partial pressure be above a given threshold (PaO2 greater than 50mm Hg). Weaning studies focus on finding methods to monitor and predict the outcome of mechanical ventilator weaning as well as finding ventilatory support techniques which will facilitate successful weaning. Present methods include intermittent mandatory ventilation, intermittent positive pressure ventilation, and mandatory minute volume ventilation.
Injury following pressure changes; includes injury to the eustachian tube, ear drum, lung and stomach.
The exchange of OXYGEN and CARBON DIOXIDE between alveolar air and pulmonary capillary blood that occurs across the BLOOD-AIR BARRIER.
Mechanical devices used to produce or assist pulmonary ventilation.
An infant during the first month after birth.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
A characteristic symptom complex.
The posture of an individual lying face down.
Failure to adequately provide oxygen to cells of the body and to remove excess carbon dioxide from them. (Stedman, 25th ed)
Lung damage that is caused by the adverse effects of PULMONARY VENTILATOR usage. The high frequency and tidal volumes produced by a mechanical ventilator can cause alveolar disruption and PULMONARY EDEMA.
A human infant born before 37 weeks of GESTATION.
Damage to any compartment of the lung caused by physical, chemical, or biological agents which characteristically elicit inflammatory reaction. These inflammatory reactions can either be acute and dominated by NEUTROPHILS, or chronic and dominated by LYMPHOCYTES and MACROPHAGES.
Hospital units providing continuous surveillance and care to acutely ill patients.
The physical or mechanical action of the LUNGS; DIAPHRAGM; RIBS; and CHEST WALL during respiration. It includes airflow, lung volume, neural and reflex controls, mechanoreceptors, breathing patterns, etc.
The capability of the LUNGS to distend under pressure as measured by pulmonary volume change per unit pressure change. While not a complete description of the pressure-volume properties of the lung, it is nevertheless useful in practice as a measure of the comparative stiffness of the lung. (From Best & Taylor's Physiological Basis of Medical Practice, 12th ed, p562)
The total volume of gas inspired or expired per unit of time, usually measured in liters per minute.
Measurement of oxygen and carbon dioxide in the blood.
Small polyhedral outpouchings along the walls of the alveolar sacs, alveolar ducts and terminal bronchioles through the walls of which gas exchange between alveolar air and pulmonary capillary blood takes place.
Advanced and highly specialized care provided to medical or surgical patients whose conditions are life-threatening and require comprehensive care and constant monitoring. It is usually administered in specially equipped units of a health care facility.
Supplying a building or house, their rooms and corridors, with fresh air. The controlling of the environment thus may be in public or domestic sites and in medical or non-medical locales. (From Dorland, 28th ed)
That part of the RESPIRATORY TRACT or the air within the respiratory tract that does not exchange OXYGEN and CARBON DIOXIDE with pulmonary capillary blood.
A procedure involving placement of a tube into the trachea through the mouth or nose in order to provide a patient with oxygen and anesthesia.
Excessive accumulation of extravascular fluid in the lung, an indication of a serious underlying disease or disorder. Pulmonary edema prevents efficient PULMONARY GAS EXCHANGE in the PULMONARY ALVEOLI, and can be life-threatening.
An acronym for Acute Physiology and Chronic Health Evaluation, a scoring system using routinely collected data and providing an accurate, objective description for a broad range of intensive care unit admissions, measuring severity of illness in critically ill patients.
An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
A disease or state in which death is possible or imminent.
A pulmonary surfactant associated-protein that plays an essential role in alveolar stability by lowering the surface tension at the air-liquid interface. Inherited deficiency of pulmonary surfactant-associated protein B is one cause of RESPIRATORY DISTRESS SYNDROME, NEWBORN.
Washing liquid obtained from irrigation of the lung, including the BRONCHI and the PULMONARY ALVEOLI. It is generally used to assess biochemical, inflammatory, or infection status of the lung.
Pathological processes involving any part of the LUNG.
Application of positive pressure to the inspiratory phase when the patient has an artificial airway in place and is connected to a ventilator.
Application of a life support system that circulates the blood through an oxygenating system, which may consist of a pump, a membrane oxygenator, and a heat exchanger. Examples of its use are to assist victims of smoke inhalation injury, respiratory failure, and cardiac failure.
Health care provided to a critically ill patient during a medical emergency or crisis.
A chronic lung disease developed after OXYGEN INHALATION THERAPY or mechanical ventilation (VENTILATION, MECHANICAL) usually occurring in certain premature infants (INFANT, PREMATURE) or newborn infants with respiratory distress syndrome (RESPIRATORY DISTRESS SYNDROME, NEWBORN). Histologically, it is characterized by the unusual abnormalities of the bronchioles, such as METAPLASIA, decrease in alveolar number, and formation of CYSTS.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Absence of air in the entire or part of a lung, such as an incompletely inflated neonate lung or a collapsed adult lung. Pulmonary atelectasis can be caused by airway obstruction, lung compression, fibrotic contraction, or other factors.
Infection of the lung often accompanied by inflammation.
The pressure that would be exerted by one component of a mixture of gases if it were present alone in a container. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
A progressive condition usually characterized by combined failure of several organs such as the lungs, liver, kidney, along with some clotting mechanisms, usually postinjury or postoperative.
A purely physical condition which exists within any material because of strain or deformation by external forces or by non-uniform thermal expansion; expressed quantitatively in units of force per unit area.
Surgical formation of an opening into the trachea through the neck, or the opening so created.
The age of the conceptus, beginning from the time of FERTILIZATION. In clinical obstetrics, the gestational age is often estimated as the time from the last day of the last MENSTRUATION which is about 2 weeks before OVULATION and fertilization.
Inhaling liquid or solids, such as stomach contents, into the RESPIRATORY TRACT. When this causes severe lung damage, it is called ASPIRATION PNEUMONIA.
Devices in which blood and oxygen are separated by a semipermeable membrane, generally of Teflon or polypropylene, across which gas exchange occurs. The membrane may be arranged as a series of parallel plates or as a number of hollow fibers; in the latter arrangement, the blood may flow inside the fibers, which are surrounded by gas, or the blood may flow outside the fibers and the gas inside the fibers. (Dorland, 28th ed)
The act of breathing with the LUNGS, consisting of INHALATION, or the taking into the lungs of the ambient air, and of EXHALATION, or the expelling of the modified air which contains more CARBON DIOXIDE than the air taken in (Blakiston's Gould Medical Dictionary, 4th ed.). This does not include tissue respiration (= OXYGEN CONSUMPTION) or cell respiration (= CELL RESPIRATION).
Measurement of the amount of air that the lungs may contain at various points in the respiratory cycle.
A respiratory distress syndrome in newborn infants, usually premature infants with insufficient PULMONARY SURFACTANTS. The disease is characterized by the formation of a HYALINE-like membrane lining the terminal respiratory airspaces (PULMONARY ALVEOLI) and subsequent collapse of the lung (PULMONARY ATELECTASIS).
Complex pharmaceutical substances, preparations, or matter derived from organisms usually obtained by biological methods or assay.
A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
Elements of limited time intervals, contributing to particular results or situations.
Functional competence of specific organs or body systems of the FETUS in utero.
An accumulation of air or gas in the PLEURAL CAVITY, which may occur spontaneously or as a result of trauma or a pathological process. The gas may also be introduced deliberately during PNEUMOTHORAX, ARTIFICIAL.
The force per unit area that the air exerts on any surface in contact with it. Primarily used for articles pertaining to air pressure within a closed environment.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
Usually high-molecular-weight, straight-chain primary alcohols, but can also range from as few as 4 carbons, derived from natural fats and oils, including lauryl, stearyl, oleyl, and linoleyl alcohols. They are used in pharmaceuticals, cosmetics, detergents, plastics, and lube oils and in textile manufacture. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
A clinical manifestation of abnormal increase in the amount of carbon dioxide in arterial blood.
Measurement of the various processes involved in the act of respiration: inspiration, expiration, oxygen and carbon dioxide exchange, lung volume and compliance, etc.
Inhalation of oxygen aimed at restoring toward normal any pathophysiologic alterations of gas exchange in the cardiopulmonary system, as by the use of a respirator, nasal catheter, tent, chamber, or mask. (From Dorland, 27th ed & Stedman, 25th ed)
Techniques for administering artificial respiration without the need for INTRATRACHEAL INTUBATION.
Hospital units providing continuing surveillance and care to acutely ill newborn infants.
Hospital units providing continuous surveillance and care to acutely ill infants and children. Neonates are excluded since INTENSIVE CARE UNITS, NEONATAL is available.
Care of patients with deficiencies and abnormalities associated with the cardiopulmonary system. It includes the therapeutic use of medical gases and their administrative apparatus, environmental control systems, humidification, aerosols, ventilatory support, bronchopulmonary drainage and exercise, respiratory rehabilitation, assistance with cardiopulmonary resuscitation, and maintenance of natural, artificial, and mechanical airways.
Disease having a short and relatively severe course.
Respiratory support system used primarily with rates of about 100 to 200/min with volumes of from about one to three times predicted anatomic dead space. Used to treat respiratory failure and maintain ventilation under severe circumstances.
The circulation of the BLOOD through the LUNGS.
RESPIRATORY MUSCLE contraction during INHALATION. The work is accomplished in three phases: LUNG COMPLIANCE work, that required to expand the LUNGS against its elastic forces; tissue resistance work, that required to overcome the viscosity of the lung and chest wall structures; and AIRWAY RESISTANCE work, that required to overcome airway resistance during the movement of air into the lungs. Work of breathing does not refer to expiration, which is entirely a passive process caused by elastic recoil of the lung and chest cage. (Guyton, Textbook of Medical Physiology, 8th ed, p406)
A pulmonary surfactant associated protein that plays a role in alveolar stability by lowering the surface tension at the air-liquid interface. It is a membrane-bound protein that constitutes 1-2% of the pulmonary surfactant mass. Pulmonary surfactant-associated protein C is one of the most hydrophobic peptides yet isolated and contains an alpha-helical domain with a central poly-valine segment that binds to phospholipid bilayers.
Continuous care and monitoring of newborn infants with life-threatening conditions, in any setting.
The administration of drugs by the respiratory route. It includes insufflation into the respiratory tract.
A vital statistic measuring or recording the rate of death from any cause in hospitalized populations.
Serious INFLAMMATION of the LUNG in patients who required the use of PULMONARY VENTILATOR. It is usually caused by cross bacterial infections in hospitals (NOSOCOMIAL INFECTIONS).
Surgical incision of the trachea.
Mechanical ventilation delivered to match the patient's efforts in breathing as detected by the interactive ventilation device.
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
Introduction of a tube into a hollow organ to restore or maintain patency if obstructed. It is differentiated from CATHETERIZATION in that the insertion of a catheter is usually performed for the introducing or withdrawing of fluids from the body.
A type of lung inflammation resulting from the aspiration of food, liquid, or gastric contents into the upper RESPIRATORY TRACT.
The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
The ratio of alveolar ventilation to simultaneous alveolar capillary blood flow in any part of the lung. (Stedman, 25th ed)
Proteins found in the LUNG that act as PULMONARY SURFACTANTS.
X-ray visualization of the chest and organs of the thoracic cavity. It is not restricted to visualization of the lungs.
Diseases of newborn infants present at birth (congenital) or developing within the first month of birth. It does not include hereditary diseases not manifesting at birth or within the first 30 days of life nor does it include inborn errors of metabolism. Both HEREDITARY DISEASES and METABOLISM, INBORN ERRORS are available as general concepts.
Water content outside of the lung vasculature. About 80% of a normal lung is made up of water, including intracellular, interstitial, and blood water. Failure to maintain the normal homeostatic fluid exchange between the vascular space and the interstitium of the lungs can result in PULMONARY EDEMA and flooding of the alveolar space.
Continuous recording of the carbon dioxide content of expired air.
A clear, yellowish liquid that envelopes the FETUS inside the sac of AMNION. In the first trimester, it is likely a transudate of maternal or fetal plasma. In the second trimester, amniotic fluid derives primarily from fetal lung and kidney. Cells or substances in this fluid can be removed for prenatal diagnostic tests (AMNIOCENTESIS).
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
Physiologically, the opposition to flow of air caused by the forces of friction. As a part of pulmonary function testing, it is the ratio of driving pressure to the rate of air flow.
The period of confinement of a patient to a hospital or other health facility.
An infant whose weight at birth is less than 1500 grams (3.3 lbs), regardless of gestational age.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
Washing out of the lungs with saline or mucolytic agents for diagnostic or therapeutic purposes. It is very useful in the diagnosis of diffuse pulmonary infiltrates in immunosuppressed patients.
The force acting on the surface of a liquid, tending to minimize the area of the surface. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
An abundant pulmonary surfactant-associated protein that binds to a variety of lung pathogens, resulting in their opsinization. It also stimulates MACROPHAGES to undergo PHAGOCYTOSIS of microorganisms. Surfactant protein A contains a N-terminal collagen-like domain and a C-terminal lectin domain that are characteristic of members of the collectin family of proteins.
A type of stress exerted uniformly in all directions. Its measure is the force exerted per unit area. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Pulmonary injury following the breathing in of toxic smoke from burning materials such as plastics, synthetics, building materials, etc. This injury is the most frequent cause of death in burn patients.
Relatively complete absence of oxygen in one or more tissues.
A technique of respiratory therapy, in either spontaneously breathing or mechanically ventilated patients, in which airway pressure is maintained above atmospheric pressure throughout the respiratory cycle by pressurization of the ventilatory circuit. (On-Line Medical Dictionary [Internet]. Newcastle upon Tyne(UK): The University Dept. of Medical Oncology: The CancerWEB Project; c1997-2003 [cited 2003 Apr 17]. Available from: http://cancerweb.ncl.ac.uk/omd/)
The continuous measurement of physiological processes, blood pressure, heart rate, renal output, reflexes, respiration, etc., in a patient or experimental animal; includes pharmacologic monitoring, the measurement of administered drugs or their metabolites in the blood, tissues, or urine.
The musculofibrous partition that separates the THORACIC CAVITY from the ABDOMINAL CAVITY. Contraction of the diaphragm increases the volume of the thoracic cavity aiding INHALATION.
A glucocorticoid given orally, parenterally, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. Its lack of mineralocorticoid properties makes betamethasone particularly suitable for treating cerebral edema and congenital adrenal hyperplasia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p724)
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Removal of an endotracheal tube from the patient.
Drugs that interrupt transmission of nerve impulses at the skeletal neuromuscular junction. They can be of two types, competitive, stabilizing blockers (NEUROMUSCULAR NONDEPOLARIZING AGENTS) or noncompetitive, depolarizing agents (NEUROMUSCULAR DEPOLARIZING AGENTS). Both prevent acetylcholine from triggering the muscle contraction and they are used as anesthesia adjuvants, as relaxants during electroshock, in convulsive states, etc.
The cartilaginous and membranous tube descending from the larynx and branching into the right and left main bronchi.
Therapy whose basic objective is to restore the volume and composition of the body fluids to normal with respect to WATER-ELECTROLYTE BALANCE. Fluids may be administered intravenously, orally, by intermittent gavage, or by HYPODERMOCLYSIS.
The volume of air remaining in the LUNGS at the end of a normal, quiet expiration. It is the sum of the RESIDUAL VOLUME and the EXPIRATORY RESERVE VOLUME. Common abbreviation is FRC.
The removal of secretions, gas or fluid from hollow or tubular organs or cavities by means of a tube and a device that acts on negative pressure.
A pathological condition manifested by failure to perfuse or oxygenate vital organs.
An infant having a birth weight of 2500 gm. (5.5 lb.) or less but INFANT, VERY LOW BIRTH WEIGHT is available for infants having a birth weight of 1500 grams (3.3 lb.) or less.
Application of positive pressure to the inspiratory phase of spontaneous respiration.
Diseases of the respiratory system in general or unspecified or for a specific respiratory disease not available.
Protein-lipid combinations abundant in brain tissue, but also present in a wide variety of animal and plant tissues. In contrast to lipoproteins, they are insoluble in water, but soluble in a chloroform-methanol mixture. The protein moiety has a high content of hydrophobic amino acids. The associated lipids consist of a mixture of GLYCEROPHOSPHATES; CEREBROSIDES; and SULFOGLYCOSPHINGOLIPIDS; while lipoproteins contain PHOSPHOLIPIDS; CHOLESTEROL; and TRIGLYCERIDES.
An acute form of TUBERCULOSIS in which minute tubercles are formed in a number of organs of the body due to dissemination of the bacilli through the blood stream.
Drugs used to induce drowsiness or sleep or to reduce psychological excitement or anxiety.
A class of statistical methods applicable to a large set of probability distributions used to test for correlation, location, independence, etc. In most nonparametric statistical tests, the original scores or observations are replaced by another variable containing less information. An important class of nonparametric tests employs the ordinal properties of the data. Another class of tests uses information about whether an observation is above or below some fixed value such as the median, and a third class is based on the frequency of the occurrence of runs in the data. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1284; Corsini, Concise Encyclopedia of Psychology, 1987, p764-5)
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
Respiratory retention of carbon dioxide. It may be chronic or acute.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
A syndrome of persistent PULMONARY HYPERTENSION in the newborn infant (INFANT, NEWBORN) without demonstrable HEART DISEASES. This neonatal condition can be caused by severe pulmonary vasoconstriction (reactive type), hypertrophy of pulmonary arterial muscle (hypertrophic type), or abnormally developed pulmonary arterioles (hypoplastic type). The newborn patient exhibits CYANOSIS and ACIDOSIS due to the persistence of fetal circulatory pattern of right-to-left shunting of blood through a patent ductus arteriosus (DUCTUS ARTERIOSUS, PATENT) and at times a patent foramen ovale (FORAMEN OVALE, PATENT).
A condition caused by inhalation of MECONIUM into the LUNG of FETUS or NEWBORN, usually due to vigorous respiratory movements during difficult PARTURITION or respiratory system abnormalities. Meconium aspirate may block small airways leading to difficulties in PULMONARY GAS EXCHANGE and ASPIRATION PNEUMONIA.
The act of blowing a powder, vapor, or gas into any body cavity for experimental, diagnostic, or therapeutic purposes.
An abnormal increase in the amount of oxygen in the tissues and organs.
Liquid perfluorinated carbon compounds which may or may not contain a hetero atom such as nitrogen, oxygen or sulfur, but do not contain another halogen or hydrogen atom. This concept includes fluorocarbon emulsions and fluorocarbon blood substitutes.
A subtype of INFLUENZA A VIRUS with the surface proteins hemagglutinin 1 and neuraminidase 1. The H1N1 subtype was responsible for the Spanish flu pandemic of 1918.
Degeneration of white matter adjacent to the CEREBRAL VENTRICLES following cerebral hypoxia or BRAIN ISCHEMIA in neonates. The condition primarily affects white matter in the perfusion zone between superficial and deep branches of the MIDDLE CEREBRAL ARTERY. Clinical manifestations include VISION DISORDERS; CEREBRAL PALSY; PARAPLEGIA; SEIZURES; and cognitive disorders. (From Adams et al., Principles of Neurology, 6th ed, p1021; Joynt, Clinical Neurology, 1997, Ch4, pp30-1)
Stress wherein emotional factors predominate.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
Blocking of a blood vessel by fat deposits in the circulation. It is often seen after fractures of large bones or after administration of CORTICOSTEROIDS.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
The administration of therapeutic agents drop by drop, as eye drops, ear drops, or nose drops. It is also administered into a body space or cavity through a catheter. It differs from THERAPEUTIC IRRIGATION in that the irrigate is removed within minutes, but the instillate is left in place.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Physiological processes and properties of the RESPIRATORY SYSTEM as a whole or of any of its parts.
Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.
The property of blood capillary ENDOTHELIUM that allows for the selective exchange of substances between the blood and surrounding tissues and through membranous barriers such as the BLOOD-AIR BARRIER; BLOOD-AQUEOUS BARRIER; BLOOD-BRAIN BARRIER; BLOOD-NERVE BARRIER; BLOOD-RETINAL BARRIER; and BLOOD-TESTIS BARRIER. Small lipid-soluble molecules such as carbon dioxide and oxygen move freely by diffusion. Water and water-soluble molecules cannot pass through the endothelial walls and are dependent on microscopic pores. These pores show narrow areas (TIGHT JUNCTIONS) which may limit large molecule movement.
Endoscopic examination, therapy or surgery of the bronchi.
The mass or quantity of heaviness of an individual at BIRTH. It is expressed by units of pounds or kilograms.
Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include, but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status.
A nitrogen-free class of lipids present in animal and particularly plant tissues and composed of one mole of glycerol and 1 or 2 moles of phosphatidic acid. Members of this group differ from one another in the nature of the fatty acids released on hydrolysis.
Colloids with a gaseous dispersing phase and either liquid (fog) or solid (smoke) dispersed phase; used in fumigation or in inhalation therapy; may contain propellant agents.
Artificial respiration (RESPIRATION, ARTIFICIAL) using an oxygenated fluid.
A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.
The volume of BLOOD passing through the HEART per unit of time. It is usually expressed as liters (volume) per minute so as not to be confused with STROKE VOLUME (volume per beat).
Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.
An acute viral infection in humans involving the respiratory tract. It is marked by inflammation of the NASAL MUCOSA; the PHARYNX; and conjunctiva, and by headache and severe, often generalized, myalgia.
The posture of an individual lying face up.
A complication of multiple rib fractures, rib and sternum fractures, or thoracic surgery. A portion of the chest wall becomes isolated from the thoracic cage and exhibits paradoxical respiration.
A transient absence of spontaneous respiration.
Moving a patient into a specific position or POSTURE to facilitate examination, surgery, or for therapeutic purposes.
A systemic inflammatory response to a variety of clinical insults, characterized by two or more of the following conditions: (1) fever >38 degrees C or HYPOTHERMIA 90 beat/minute; (3) tachypnea >24 breaths/minute; (4) LEUKOCYTOSIS >12,000 cells/cubic mm or 10% immature forms. While usually related to infection, SIRS can also be associated with noninfectious insults such as TRAUMA; BURNS; or PANCREATITIS. If infection is involved, a patient with SIRS is said to have SEPSIS.
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
An abundant pulmonary surfactant-associated protein that binds to a variety of lung pathogens and enhances their opsinization and killing by phagocytic cells. Surfactant protein D contains a N-terminal collagen-like domain and a C-terminal lectin domain that are characteristic of members of the collectin family of proteins.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)
Drugs used for their effects on the respiratory system.
Inflammation of the lung parenchyma that is caused by a viral infection.
Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
Inflammation of the lung parenchyma that is caused by bacterial infections.
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
An enzyme that catalyzes the hydrolysis of proteins, including elastin. It cleaves preferentially bonds at the carboxyl side of Ala and Val, with greater specificity for Ala. EC 3.4.21.37.
A cluster of metabolic risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components of metabolic syndrome X include excess ABDOMINAL FAT; atherogenic DYSLIPIDEMIA; HYPERTENSION; HYPERGLYCEMIA; INSULIN RESISTANCE; a proinflammatory state; and a prothrombotic (THROMBOSIS) state. (from AHA/NHLBI/ADA Conference Proceedings, Circulation 2004; 109:551-556)
A respiratory stimulant that enhances respiration by acting as an agonist of peripheral chemoreceptors located on the carotid bodies. The drug increases arterial oxygen tension while decreasing arterial carbon dioxide tension in patients with chronic obstructive pulmonary disease. It may also prove useful in the treatment of nocturnal oxygen desaturation without impairing the quality of sleep.
Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural continuity.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
Multiple physical insults or injuries occurring simultaneously.
The rate at which oxygen is used by a tissue; microliters of oxygen STPD used per milligram of tissue per hour; the rate at which oxygen enters the blood from alveolar gas, equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body. (Stedman, 25th ed, p346)
General or unspecified injuries to the chest area.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Complete or severe weakness of the muscles of respiration. This condition may be associated with MOTOR NEURON DISEASES; PERIPHERAL NERVE DISEASES; NEUROMUSCULAR JUNCTION DISEASES; SPINAL CORD DISEASES; injury to the PHRENIC NERVE; and other disorders.
Precise and detailed plans for the study of a medical or biomedical problem and/or plans for a regimen of therapy.
Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides see GLYCEROPHOSPHOLIPIDS) or sphingosine (SPHINGOLIPIDS). They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
The washing of a body cavity or surface by flowing water or solution for therapy or diagnosis.
The behaviors of materials under force.
CHILDBIRTH before 37 weeks of PREGNANCY (259 days from the first day of the mother's last menstrual period, or 245 days after FERTILIZATION).
Removal of toxins or metabolites from the circulation by the passing of blood, within a suitable extracorporeal circuit, over semipermeable microcapsules containing adsorbents (e.g., activated charcoal) or enzymes, other enzyme preparations (e.g., gel-entrapped microsomes, membrane-free enzymes bound to artificial carriers), or other adsorbents (e.g., various resins, albumin-conjugated agarose).
Any hindrance to the passage of air into and out of the lungs.
The introduction of whole blood or blood component directly into the blood stream. (Dorland, 27th ed)
Body ventilators that assist ventilation by applying intermittent subatmospheric pressure around the thorax, abdomen, or airway and periodically expand the chest wall and inflate the lungs. They are relatively simple to operate and do not require tracheostomy. These devices include the tank ventilators ("iron lung"), Portalung, Pneumowrap, and chest cuirass ("tortoise shell").
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
A congenital heart defect characterized by the persistent opening of fetal DUCTUS ARTERIOSUS that connects the PULMONARY ARTERY to the descending aorta (AORTA, DESCENDING) allowing unoxygenated blood to bypass the lung and flow to the PLACENTA. Normally, the ductus is closed shortly after birth.
A disorder characterized by procoagulant substances entering the general circulation causing a systemic thrombotic process. The activation of the clotting mechanism may arise from any of a number of disorders. A majority of the patients manifest skin lesions, sometimes leading to PURPURA FULMINANS.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
These include the muscles of the DIAPHRAGM and the INTERCOSTAL MUSCLES.
An acute infectious disease caused by ORIENTIA TSUTSUGAMUSHI. It is limited to eastern and southeastern Asia, India, northern Australia, and the adjacent islands. Characteristics include the formation of a primary cutaneous lesion at the site of the bite of an infected mite, fever lasting about two weeks, and a maculopapular rash.
Injuries caused by impact with a blunt object where there is no penetration of the skin.
Extraction of the FETUS by means of abdominal HYSTEROTOMY.
Any disorder marked by obstruction of conducting airways of the lung. AIRWAY OBSTRUCTION may be acute, chronic, intermittent, or persistent.
Spontaneous tearing of the membranes surrounding the FETUS any time before the onset of OBSTETRIC LABOR. Preterm PROM is membrane rupture before 37 weeks of GESTATION.
A method, developed by Dr. Virginia Apgar, to evaluate a newborn's adjustment to extrauterine life. Five items - heart rate, respiratory effort, muscle tone, reflex irritability, and color - are evaluated 60 seconds after birth and again five minutes later on a scale from 0-2, 0 being the lowest, 2 being normal. The five numbers are added for the Apgar score. A score of 0-3 represents severe distress, 4-7 indicates moderate distress, and a score of 7-10 predicts an absence of difficulty in adjusting to extrauterine life.
Works about clinical trials that involve at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table.
... of chronic obstructive pulmonary disease and in adult respiratory distress syndrome where conventional mechanical ventilation ... Pisani, L; Corcione, N; Nava, S (February 2016). "Management of acute hypercapnic respiratory failure". Current Opinion in ... from the bloodstream in people who have elevated levels of carbon dioxide as a result of respiratory failure. The use of ... in patients with acute respiratory failure". Intensive Care Medicine. 43 (4): 519-530. doi:10.1007/s00134-016-4673-0. PMID ...
Acute respiratory distress syndrome Mechanical ventilation Irwin, Richard S.; Rippe, James M. (2003). Irwin and Rippe's ... has been accepted progressively in critical care for adult, pediatric, and neonatal patients requiring mechanical ventilation ... In acute respiratory distress syndrome (ARDS), decreasing the tidal volume on the ventilator (usually 6-8 mL/kg) to 4-6 mL/kg ... respiratory insufficient patients in which oxygenation has become so difficult that the optimal mode of mechanical ventilation ...
... is usually treated with mechanical ventilation in the intensive care unit (ICU). Mechanical ... Acute respiratory distress syndrome. Synonyms. Respiratory distress syndrome (RDS), adult respiratory distress syndrome, shock ... "adult respiratory distress syndrome" has at times been used to differentiate ARDS from "infant respiratory distress syndrome" ... Acute respiratory distress syndrome. Acute liver failure. Respiratory failure. Multiple organ dysfunction syndrome. *Neonatal ...
Shanholtz C, Brower R (1994). "Should inverse ratio ventilation be used in adult respiratory distress syndrome?". Am J Respir ... with low distending pressures in acute respiratory distress syndrome. A prospective randomized study on mechanical ventilation ... inverse ratio ventilation that avoids air trapping in the adult respiratory distress syndrome". Crit Care Med. 23 (2): 279-85. ... effects of pressure-controlled ventilation with and without inverse ratio in the adult respiratory distress syndrome". Chest. ...
"Airway pressure release ventilation: an alternative mode of mechanical ventilation in acute respiratory distress syndrome". ... while at rest, a typical adult will take an average of 18 breaths per minute. Most people are unaware of their breathing ... Continuous spontaneous ventilation is any mode of mechanical ventilation where every breath is spontaneous (i.e., patient ... Some modes of mechanical ventilation require spontaneous ventilation, some of these include: Bilevel positive airway pressure ( ...
... is usually treated with mechanical ventilation in the intensive care unit (ICU). Mechanical ... "adult respiratory distress syndrome" has at times been used to differentiate ARDS from "infant respiratory distress syndrome" ... particularly during mechanical ventilation.[citation needed] Acute respiratory distress syndrome was first described in 1967 by ... "Effect of prone positioning during mechanical ventilation on mortality among patients with acute respiratory distress syndrome ...
Allardet-Servent J (2011). "High-frequency oscillatory ventilation in adult patients with acute respiratory distress syndrome: ... Adrian A. Maung & Lewis J. Kaplan (July 2011). "Airway pressure release ventilation in acute respiratory distress syndrome". ... Modes of mechanical ventilation are one of the most important aspects of the usage of mechanical ventilation. The mode refers ... Medicine portal Table of modes of mechanical ventilation Mechanical ventilation - Method to mechanically assist or replace ...
VALI is most common in people receiving mechanical ventilation for acute lung injury or acute respiratory distress syndrome ( ... mechanical ventilation, lengths of stay and lung injury in adults without acute lung injury". Cochrane Database of Systematic ... Rouby JJ, Brochard L (2007). "Tidal recruitment and overinflation in acute respiratory distress syndrome: yin and yang". Am J ... This may be regarded as the over-stretching of the airways and alveoli.[citation needed] During mechanical ventilation, the ...
Other severe complications, including infections and acute respiratory distress syndrome (ARDS) occur in up to half of cases. ... Mechanical ventilation aims to reduce pulmonary edema and increase oxygenation. Ventilation can reopen collapsed alveoli, but ... Ridley SC (1998). "Surgery for adults". In Pryor JA, Webber BR. Physiotherapy for Respiratory and Cardiac Problems. Edinburgh: ... Pulmonary contusion or its complications such as acute respiratory distress syndrome may cause lungs to lose compliance ( ...
... is not used to treat adults with adult respiratory distress syndrome because the evidence regarding its ... Intubation via mechanical ventilation is less effective than the LISA method within the first 72 hours of birth. Exogenous ... Respiratory Distress Syndrome~treatment at eMedicine Härtel, Christoph; Paul, Pia; Hanke, Kathrin; Humberg, Alexander; Kribs, ... This condition that the baby has is called newborn respiratory distress syndrome, and it is treatable. Surfactant coat the ...
Mechanical ventilation becomes more complex as acute respiratory distress syndrome (ARDS) develops in COVID‑19 and oxygenation ... mortality for adult respiratory patients. Initial use of ECMO in COVID-19 patients from China early in the pandemic suggested ... since the 1980s to treat respiratory failure and acute respiratory distress syndrome when conventional mechanical ventilation ... "Treatment for severe acute respiratory distress syndrome from COVID-19". The Lancet. Respiratory Medicine. 8 (5): 433-434. doi: ...
"Effect of prone positioning during mechanical ventilation on mortality among patients with acute respiratory distress syndrome ... These recommended the use of proning: For mechanically ventilated adults with COVID-19 and moderate to severe ARDS, we suggest ... This is used in the treatment of patients in intensive care with acute respiratory distress syndrome (ARDS). It has been ... Prone positioning may be used for people suffering from acute respiratory distress syndrome (ARDS) to improve their breathing. ...
For adults with moderate or severe acute respiratory distress syndrome (ARDS) undergoing mechanical ventilation, there is a ... Pneumonia can cause respiratory failure by triggering acute respiratory distress syndrome (ARDS), which results from a ... October 2017). "Prone Position for Acute Respiratory Distress Syndrome. A Systematic Review and Meta-Analysis". Annals of the ... This may include, among others: empyema, lung abscess, bronchiolitis obliterans, acute respiratory distress syndrome, sepsis, ...
"High-frequency oscillatory ventilation for adult respiratory distress syndrome--a pilot study". Critical Care Medicine. 25 (6 ... High-frequency ventilation is a type of mechanical ventilation which utilizes a respiratory rate greater than four times the ... "High-frequency percussive ventilation improves oxygenation in trauma patients with acute respiratory distress syndrome: a ... "Systematic review of determinants of mortality in high-frequency oscillatory ventilation in acute respiratory distress syndrome ...
Hess DR (2011). "Approaches to conventional mechanical ventilation of the patient with acute respiratory distress syndrome". ... Pain medicine such as opioids are sometimes used in adults and infants who require mechanical ventilation. For preterm or full ... Acute Respiratory Distress Syndrome Network) (2000). "Ventilation with lower tidal volumes as compared with traditional tidal ... Mechanical ventilation, assisted ventilation or intermittent mandatory ventilation (IMV), is the medical term for artificial ...
ഇരട്ടന്യുമോണിയ (തീവ്ര ശ്വസനനിരോധ സിൻഡ്രോം,Acute Respiratory Distress Syndrome)[തിരുത്തുക]. രണ്ട് ശ്വാസകോശത്തെയും ഒരുപോലെ ... Carlucci A, et al.Noninvasive versus conventional mechanical ventilation. An epidemiologic survey. Am J Respir Crit Care Med. ... Ward JI, et al.Efficacy of an acellular pertussis vaccine among adolescents and adults.N Engl J Med. 2005 Oct 13;353(15):1555- ... 2.3.3 ഇരട്ടന്യുമോണിയ (തീവ്ര ശ്വസനനിരോധ സിൻഡ്രോം,Acute Respiratory Distress Syndrome). *2.3.4 ഇയോസിനോഫിലിക ന്യുമോണിയ ( ...
Syndromes such as respiratory distress syndrome, congenital heart disease, pneumothorax, and shock may lead to breathing ... In the chronic setting, indications for tracheotomy include the need for long-term mechanical ventilation and removal of ... There are significant differences in airway anatomy and respiratory physiology between children and adults, and these are taken ... acute respiratory distress syndrome (ARDS), or near-drowning. Specifically, intubation is considered if the arterial partial ...
... of meconium aspiration syndrome in newborn infants 07-17-1995 Treatment of acute respiratory distress syndrome in adults. 05-23 ... Lucinactant is indicated to improve lung function and reduce duration and risk of mechanical ventilation in children. It can be ... for acute respiratory distress syndrome". American Journal of Respiratory and Critical Care Medicine. 160 (4): 1188-95. doi: ... Lucinactant (trade name Surfaxin) is a liquid medication used to treat infant respiratory distress syndrome. It is a pulmonary ...
She works in intensive care at the UCSF Medical Center where she specialises in acute respiratory distress syndrome. During the ... which may be more responsive to mechanical ventilation and pharmacotherapy. This particular phenotype is associated with ... and emphasised that e-cigarettes should not be used by youths or young adults. In 2019 she was elected to the American Society ... Sinha, Pratik; Calfee, Carolyn S. (2019-07-01). "Peeking under the Hood of Acute Respiratory Distress Syndrome Phenotypes: ...
Some of these conditions include acute respiratory distress syndrome, lung consolidations, pleural adhesions, and pulmonary ... However, these exam techniques can be complicated by a variety of factors including the presence of mechanical ventilation, ... estimates of lean body mass in adults; proxy measures of muscle quality (i.e., tissue composition) in older adults with ... However, since the mechanical scanning is slow, it is difficult to make 3D images of moving tissues. Recently, 2-D phased array ...
The occurrence of symptoms of bronchopulmonary dysplasia or acute respiratory distress syndrome is treated by lowering the ... Other groups at higher risk for oxygen toxicity are patients on mechanical ventilation with exposure to levels of oxygen ... even in adults). However, they are likely to be more susceptible to respiratory infections for the rest of their lives and the ... with evidence of diffuse alveolar damage and the onset of acute respiratory distress syndrome usually occurring after 48 hours ...
1996-02-07). "Initial Experience With Partial Liquid Ventilation in Adult Patients With the Acute Respiratory Distress Syndrome ... Conventional mechanical ventilation delivers tidal volume breaths on top of it. This mode of liquid ventilation currently seems ... The first medical use of liquid breathing was treatment of premature babies and adults with acute respiratory distress syndrome ... September 1996). "Partial liquid ventilation with perflubron in premature infants with severe respiratory distress syndrome. ...
A multi-center, randomized controlled trial of dexamethasone in treating acute respiratory distress syndrome (ARDS), published ... mechanical ventilation, or extracorporeal membrane oxygenation (ECMO). The IDSA recommends against the use of glucocorticoids ... The REMAP‑CAP study in the UK found that tocilizumab was beneficial in adults with severe COVID‑19, who were critically ill and ... previously developed or used as treatments for severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS ...
In adult respiratory distress syndrome (ARDS), conservative fluid management is associated with better oxygenation and lung ... The use of mechanical ventilation in such case can cause barotrauma, infection, and oxygen toxicity, leading to acute ... respiratory distress syndrome. Fluid overload also stretches the arterial endothelium, which causes damage to the glycocalyx, ... which lead to respiratory distress; myocardial oedema and pericardial effusion, which lead to impaired contractility of the ...
pulmonary fibrosis, Infant Respiratory Distress Syndrome, weak respiratory muscles, pneumothorax. volumes are decreased. often ... The average human respiratory rate is 30-60 breaths per minute at birth,[1] decreasing to 12-20 breaths per minute in adults.[2 ... and minute ventilation by 30-40%[8][9] giving an increase in pulmonary ventilation. This is necessary to meet the increased ... respiratory minute volume. FEV1/FVC ratio. Lung function tests. spirometry. body plethysmography. peak flow meter. nitrogen ...
"Y-piece temperature and humidification during mechanical ventilation". Respiratory care. 54 (4): 480-6. PMID 19327183. Hasani, ... has shown to be useful in neonatal intensive care settings for premature infants with Infant respiratory distress syndrome, as ... Traditional oxygen therapy is limited to six liters a minute and does not begin to approach the inspiratory demand of an adult ... The cannula improves the respiratory distress, the oxygen saturation, and the patient's comfort. Its mechanism of action is the ...
... and over-stretching can lead to adult respiratory distress syndrome - a condition that requires prolonged mechanical ventilator ... In a hospital, long-term mechanical ventilation is provided by using a more complex, automated ventilator. However a frequent ... adult respiratory distress syndrome and "pulmonary injuries similar to that seen in victims of chlorine gas exposure".[7] Apart ... Massive air embolism in an adult following positive pressure ventilation. Chest 1988: 93:874-876. ...
... or intubation with mechanical ventilation. Diagnoses included pneumonitis and acute respiratory distress syndrome (ARDS). ... Adults who do not currently use tobacco products should not start using e-cigarette, or vaping, products, according to the CDC ... and acute respiratory distress syndrome (ARDS) in California were connected to vaping cannabis products that were traced back ... and acute respiratory distress syndrome necessitating extracorporeal membrane oxygenation (ECMO) Shoulder and back pain, double ...
Pressure-cycled ventilation can help alleviate symptoms in patients with acute respiratory distress syndrome by limiting the ... The synchronized intermittent mandatory ventilation (SIMV) is a similar method of mechanical ventilation that also delivers ... Fish DR, Howard RS, Wiles CM, Simon L. Respiratory arrest: a complication of cerebellar ectopia in adults. Journal of neurology ... Respiratory failure is the inability to provide adequate ventilation for the body's requirements. Respiratory arrest is also ...
George L. Waldbott, an American allergist, first described a new disease he named "smoker's respiratory syndrome" in the 1953 ... Respiratory infections such as pneumonia do not appear to increase the risk of COPD, at least in adults.[23] ... For people with type 2 respiratory failure (acutely raised CO. 2 levels) non-invasive positive pressure ventilation decreases ... Shortness of breath is a common symptom and is often the most distressing.[27] It is commonly described as: "my breathing ...
Acute respiratory distress syndrome. Acute liver failure. Respiratory failure. Multiple organ dysfunction syndrome. *Neonatal ... In the USA drotrecogin was FDA approved for the reduction of mortality in adult patients with severe sepsis (sepsis associated ... Mechanical ventilation. *Therapeutic hypothermia. *Total parenteral nutrition. *Tracheal intubation. Drugs. *Analgesics. * ... Multiple organ dysfunction syndrome. Other shock. Cardiogenic shock. Distributive shock. Anaphylaxis. Obstructive shock. ...
... correlated with illness severity and mortality in critically ill adults and in ventilated neonates with respiratory distress.[ ... Immersion foot syndromes Trench foot. Tropical immersion foot. Warm water immersion foot. Chilblains. Frostbite. Aerosol burn. ... At 4000 m, raising the oxygen concentration level by 5 percent via an oxygen concentrator and an existing ventilation system ... Hypoxic drive, a respiratory drive in which the body uses oxygen chemoreceptors to regulate the respiratory cycle ...
Acute respiratory distress syndrome. Acute liver failure. Respiratory failure. Multiple organ dysfunction syndrome. *Neonatal ... paralytics may aid successful mechanical ventilation, however evidence has also suggested that mechanical ventilation in severe ... The Surviving Sepsis Campaign has recommended 30 ml/kg of fluid to be given in adults in the first three hours followed by ... acute respiratory distress syndrome (ARDS) (PaO2/FiO2 ratio, 300), different ratio in pediatric acute respiratory distress ...
Acute respiratory distress syndrome. *Carbon monoxide inhalation, such as that from a car exhaust and the smoke's emission from ... This can occur as a result of inadequate circulation or perfusion, impaired respiratory effort, or inadequate ventilation.[14] ... of the co-sleeping adult and a small shared sleeping space (for example, both adult and infant sharing a couch). ... Smothering is the mechanical obstruction of the flow of air from the environment into the mouth and/or nostrils, for instance, ...
... yet able to support patients with acute respiratory distress syndrome.[56] Due to the coronavirus pandemic, in March 2020 the ... The availability of CCB-ICU beds,[46] mechanical ventilation[47][48] and ECMO devices[49] generally closely associated with ... "Critical care and the global burden of critical illness in adults" (PDF). The Lancet. 376 (9749): 1339-46. doi:10.1016/S0140- ... See also: Mechanical ventilation and Extracorporeal membrane oxygenation § Availability. Countries in italics are non-OECD ...
Acute respiratory distress syndrome. Acute liver failure. Respiratory failure. Multiple organ dysfunction syndrome. *Neonatal ... APACHE II was designed to measure the severity of disease for adult patients admitted to intensive care units. It has not been ... Mechanical ventilation. *Therapeutic hypothermia. *Total parenteral nutrition. *Tracheal intubation. Drugs. *Analgesics. * ... Multiple organ dysfunction syndrome. Other shock. Cardiogenic shock. Distributive shock. Anaphylaxis. Obstructive shock. ...
"Treatment for severe acute respiratory distress syndrome from COVID-19". The Lancet Respiratory Medicine. PMID 32203709. doi: ... Diaz, Raiko; Heller, Daniel (2020). Barotrauma And Mechanical Ventilation. StatPearls (StatPearls Publishing). PMID 31424810.. ... marzo de 2020). "A Trial of Lopinavir-Ritonavir in Adults Hospitalized with Severe Covid-19". The New England Journal of ... "Higher vs Lower Positive End-Expiratory Pressure in Patients With Acute Lung Injury and Acute Respiratory Distress Syndrome". ...
The occurrence of symptoms of bronchopulmonary dysplasia or acute respiratory distress syndrome is treated by lowering the ... Other groups at higher risk for oxygen toxicity are patients on mechanical ventilation with exposure to levels of oxygen ... even in adults). However, they are likely to be more susceptible to respiratory infections for the rest of their lives and the ... with evidence of diffuse alveolar damage and the onset of acute respiratory distress syndrome usually occurring after 48 hours ...
Common conditions that are treated within ICUs include acute (or adult) respiratory distress syndrome, hypertension, metastases ... 2006-07-06). "Hospital volume and the outcomes of mechanical ventilation". New England Journal of Medicine. 355 (1): 41-50. doi ... Acute respiratory distress syndrome. Acute liver failure. Respiratory failure. Multiple organ dysfunction syndrome. *Neonatal ... ICU patients often require mechanical ventilation if they have lost the ability to breathe normally. ...
Insufficient surfactant (e.g. respiratory distress syndrome in pre-term babies) .. Disorders of the respiratory system are ... Control of ventilation. Main article: Control of ventilation. Ventilation of the lungs in mammals occurs via the respiratory ... Compared to the, on average, 23 number of branchings of the respiratory tree in the adult human, the mouse has only about 13 ... Premature Babies, Lung Development & Respiratory Distress Syndrome. Pregnancy-facts.com. *^ Kanaide, Hideo; Ichiki, Toshihiro; ...
... acute respiratory distress syndrome (ARDS) (PaO2/FiO2 ratio, 300), different ratio in pediatric acute respiratory distress ... paralytics may aid successful mechanical ventilation, however evidence has also suggested that mechanical ventilation in severe ... 83,0 83,1 «Human recombinant protein C for severe sepsis and septic shock in adult and paediatric patients»։ The Cochrane ... Acute respiratory distress syndrome, sepsis, and cognitive decline: a review and case study»։ Southern Medical Journal 102 (11 ...
"Treatment for severe acute respiratory distress syndrome from COVID-19". The Lancet Respiratory Medicine. doi:10.1016/S2213- ... Diaz, Raiko; Heller, Daniel (2020). Barotrauma And Mechanical Ventilation. StatPearls. StatPearls Publishing. PMID 31424810.. ... 2020). "Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective ... "Higher vs Lower Positive End-Expiratory Pressure in Patients With Acute Lung Injury and Acute Respiratory Distress Syndrome". ...
... and infant respiratory distress syndrome caused by a deficiency in lung surfactant. An azygos lobe is a congenital anatomical ... Mechanical ventilation. *Pores of Kohn. *Secarecytosis. References[edit]. *^ a b c d e f g Drake, Richard L.; Vogl, Wayne; ... At birth the lungs are very undeveloped with only around one sixth of the alveoli of the adult lung present.[29] The alveoli ... The lower respiratory tract is part of the respiratory system, and consists of the trachea and the structures below this ...
... acute respiratory distress syndrome (ARDS) (PaO2/FiO2 ratio, 300), different ratio in pediatric acute respiratory distress ... paralytics may aid successful mechanical ventilation, however evidence has also suggested that mechanical ventilation in severe ... The Surviving Sepsis Campaign has recommended 30 ml/kg of fluid to be given in adults in the first three hours followed by ... "Acute respiratory distress syndrome, sepsis, and cognitive decline: a review and case study". Southern Medical Journal. 102 (11 ...
... acute respiratory distress syndrome (ARDS), or near-drowning. Specifically, intubation is considered if the arterial partial ... A premature infant weighing 990 grams (35 ounces), intubated and requiring mechanical ventilation in the neonatal intensive- ... There are significant differences in airway anatomy and respiratory physiology between children and adults, and these are taken ... Several open techniques exist, such as spontaneous ventilation, apnoeic ventilation or jet ventilation. Each has its own ...
... and pneumonia-induced respiratory failure is the most frequent cause of death. Unless placed on mechanical ventilation, babies ... Adult-onset). Adulthood. The adult-onset form (sometimes classified as a late-onset SMA type 3) usually manifests after the ... Symptoms are critical (including respiratory distress and poor feeding) which usually result in death within weeks. In ... The severe form manifests in the first months of life, usually with a quick and unexpected onset ("floppy baby syndrome"). ...
Mechanical ventilation *Negative pressure ventilator. *Positive pressure ventilation. Respiratory therapy. *Artificial ... Laryngoscope handle with an assortment of Macintosh blades (large adult, small adult, pediatric, infant, and neonate) ... procedure is done in an operation theatre with full preparation for resuscitative measures to deal with respiratory distress. ... "Laryngeal mask airway and fiberoptic endoscopy in an infant with Schwartz-Jampel syndrome". Anesthesiology. 82 (2): 605. doi: ...
... and infant respiratory distress syndrome caused by a deficiency in lung surfactant. An azygos lobe is a congenital anatomical ... may need the use of mechanical ventilation to ensure an adequate supply of air. ... At birth the lungs are very undeveloped with only around one sixth of the alveoli of the adult lung present.[47] The alveoli ... Respiratory epitheliumEdit. Main article: Respiratory epithelium. All of the lower respiratory tract including the trachea, ...
... non-specific signs of respiratory distress). Rales or crackles, heard initially in the lung bases, and when severe, throughout ... and the second most common for adults aged 65-84 years.[97] It is estimated that one in five adults at age 40 will develop ... Some theories invoke mechanisms that are mediated by neurohormonal activation.[37] Mechanical effects may also contribute. As ... This reduces spare capacity for ventilation, causes stiffening of the lungs and reduces the efficiency of gas exchange by ...
These systems may not be appropriate for people who are unconscious or those in respiratory distress, because of the effort ... Mechanical ventilation - Method to mechanically assist or replace spontaneous breathing. *Hyperbaric oxygen therapy ... implications for the transmission of severe acute respiratory syndrome". Chest. 125 (3): 1155-57. doi:10.1378/chest.125.3.1155 ... "American Association for Respiratory Care Clinical Practice Guideline: Oxygen therapy for adults in the acute care facility - ...
Adult female - No engorgement. Adult female - Early engorgement. Adult female - Moderate engorgement. Adult female - Full ... Respiratory muscles. Initially this results in rapid, shallow breathing with an inability to cough. In advanced stages it is ... Although pain is not regarded as being a feature of tick paralysis animals would appear to be in severe distress. Finally, the ... For hard (Ixodid) ticks it is virtually impossible for mechanical transmission to occur on its own (i.e. without some ...
... adult , mechanical ventilation in clinical trial on Comparison Study of High Frequency Percussive Ventilation With Conventional ... Patients at risk for Acute Respiratory Distress Syndrome (ARDS) will be enrolled and randomized to one of two groups. One group ... We hypothesize that patients with Acute Lung Injury (ALI )and/or Acute Respiratory Distress Syndrome (ARDS) managed primarily ... with conventional mechanical ventilation techniques, while maintaining similar oxygenation (PaO2), ventilation (PaCO2), ...
Respiratory Distress Syndrome, Newborn. Respiratory Distress Syndrome, Adult. Acute Lung Injury. Lung Diseases. Respiratory ... Risk Factors for Prolonged Invasive Mechanical Ventilation in COVID-19 Acute Respiratory Distress Syndrome. The safety and ... Risk Factors for Prolonged Invasive Mechanical Ventilation in COVID-19 Acute Respiratory Distress Syndrome. ... Respiratory Distress Syndrome, Infant Acute Respiratory Distress Syndrome ...
Respiratory Distress Syndrome, Newborn. Respiratory Distress Syndrome, Adult. Acute Lung Injury. Lung Injury. Lung Diseases. ... Respiratory Distress Syndrome, Infant Acute Respiratory Distress Syndrome ... chronic disease and acute disease leading to non-invasive mechanical ventilation or intubation and mechanical ventilation; data ... mechanical ventilation strategies and to follow patients prospectively during the whole course of their mechanical ventilation. ...
Respiratory Insufficiency. Respiratory Distress Syndrome, Adult. Respiration Disorders. Respiratory Tract Diseases. Lung ... Respiratory Distress Syndrome, Infant Acute Respiratory Distress Syndrome ... Goal Directed Mechanical Ventilation Aimed at Optimal Lung Compliance. The safety and scientific validity of this study is the ... Mechanical ventilation guided by esophageal pressure in acute lung injury. N Engl J Med. 2008 Nov 13;359(20):2095-104. doi: ...
Mechanical ventilation (33). *. Pneumonia (respiratory medicine) (91). *. Pulmonary embolism (120). *. Pulmonary emphysema (2) ...
Mechanical ventilation can induce a cytokine response that may be attenuated by a strategy to minimize overdistention and ... Respiratory Distress Syndrome, Adult / immunology* * Respiratory Distress Syndrome, Adult / therapy* * Respiratory Function ... Effect of Mechanical Ventilation on Inflammatory Mediators in Patients With Acute Respiratory Distress Syndrome: A Randomized ... Patients: Forty-four patients (mean [SD] age, 50 [18] years) with acute respiratory distress syndrome were enrolled, 7 of whom ...
Mechanical ventilation -a machine that helps you breathe; air may be delivered through a tube placed in the windpipe or through ... a (ARDS; Adult Respiratory Distress Syndrome; Non-cardiogenic Pulmonary Edema). RESOURCES. American Lung Association http://www ... Acute respiratory distress syndrome (ARDS) is a form of severe lung damage. It happens in people who are very ill or hurt. Most ... Acute respiratory distress syndrome (ARDS) is a form of severe lung damage. It happens in people who are very ill or hurt. Most ...
Acute respiratory distress syndrome (ARDS) is a condition characterized by a high permeability oedema due to loss of the ... Respiratory Distress Syndrome, Adult / etiology, physiopathology*, prevention & control. Systemic Inflammatory Response ... Acute respiratory distress syndrome (ARDS) is a condition characterized by a high permeability oedema due to loss of the ... Mechanical ventilation on such alveoli with repeated alveolar collapse and subsequent reexpansion results in severe lung ...
Scandinavian clinical practice guideline on mechanical ventilation in adults with the acute respiratory distress syndrome. ... Scandinavian clinical practice guideline on fluid and drug therapy in adults with acute respiratory distress syndrome. ... ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. ... Guidelines on the Management of Critically Ill Adults with Coronavirus Disease 2019 (COVID-19). This guideline provides ...
Scandinavian clinical practice guideline on mechanical ventilation in adults with the acute respiratory distress syndrome. ... Scandinavian clinical practice guideline on fluid and drug therapy in adults with acute respiratory distress syndrome. ... Kronisk og Akutt strålesyndrom (Acute Radiation Syndrome, ARS) - Håndbok i NBC-medisin. … og fra andre organer. For detaljer se ...
ADULT RESPIRATORY DISTRESS SYNDROME , Ventilations Parameters Applied in Emergency Medicine. A Prospective Observational Study ... Needing a invasive or noninvasive mechanical ventilation *Mechanical ventilation initiated in Prehospital or IntraHospital ... Conditions: Survival , Artificial respiration , Aspects of mortality statistics , Protective Ventilation , ADULT RESPIRATORY ... Ventilations Parameters Applied in Emergency Medicine. A Prospective Observational Study Are you eligible to participate in ...
Force ADT , * Ranieri VM , * Rubenfeld GD , et al . Acute respiratory distress syndrome: the Berlin definition. JAMA 2012;307: ... Neural control of mechanical ventilation in respiratory failure. Nat Med 1999;5:1433-6.doi:10.1038/71012 ... ii) Controlled mechanical ventilation: Patient will be ventilated in a controlled ventilation mode as long as needed for the ... SVC will automatically change the ventilator mode from controlled mechanical ventilation (pressure controlled ventilation) to ...
Respiratory Distress Syndrome, Newborn. Respiratory Distress Syndrome, Adult. Acute Lung Injury. Syndrome. Disease. Pathologic ... Respiratory Distress Syndrome, Infant Acute Respiratory Distress Syndrome ... for patients with the acute respiratory distress syndrome (ARDS) using the computerized mechanical ventilation protocols ... of Computerized Clinical Decision Support for Mechanical Ventilation of Patients With Acute Respiratory Distress Syndrome. ...
Review: Corticosteroids reduce mechanical ventilation and ARDS in inpatients with community-acquired pneumonia Annals of ... Miliary Tuberculosis and Adult Respiratory Distress Syndrome JON S. HUSEBY, M.D.; LEONARD D. HUDSON, M.D. ... Miliary Tuberculosis and Adult Respiratory Distress Syndrome. Ann Intern Med. ;85:609-611. doi: 10.7326/0003-4819-85-5-609 ... Three patients with miliary tuberculosis developed the adult respiratory distress syndrome. In two patients this complication ...
... and he required mechanical ventilation. Our experiences with this patient suggest that babesiosis should be considered in the ... Adult respiratory distress syndrome developed in the patient, ... Adult respiratory distress syndrome developed in the patient, ... and adult respiratory distress syndrome requiring mechanical ventilation.. On November 14, his therapy for babesiosis was ... and adult respiratory distress syndrome (1,9,10). The risk of developing this clinical infection is increased for elderly, ...
Adult respiratory distress syndrome. *. Asthma (93). *. Bronchiolitis (12). *. Bronchitis (16). *. Mechanical ventilation (33) ... Early out-of-hospital non-invasive ventilation is superior to standard medical treatment in patients with acute respiratory ... Characteristics of crush syndrome caused by prolonged limb compression longer than 24 h in the Sichuan earthquake Zhou ...
... we measured net alveolar fluid clearance in 79 patients with acute lung injury or the acute respiratory distress syndrome. ... with maximal alveolar fluid clearance had significantly lower mortality and a shorter duration of mechanical ventilation. In ... Respiratory Distress Syndrome, Adult / blood * Respiratory Distress Syndrome, Adult / complications * Respiratory Distress ... Respiratory Distress Syndrome, Adult / mortality * Respiratory Distress Syndrome, Adult / physiopathology* * Respiratory ...
Systemic Gas Embolism Complicating Mechanical Ventilation in the Adult Respiratory Distress Syndrome Annals of Internal ... "CHOKES": A RESPIRATORY MANIFESTATION OF AEROEMBOLISM IN HIGH ALTITUDE FLYING1 Annals of Internal Medicine; 22 (3): 398-407 ...
Information on Adult respiratory distress syndrome as a medical condition with Adult respiratory distress syndrome information ... Acute respiratory distress syndrome is usually treated with mechanical ventilation in the Intensive Care Unit. Ventilation is ... Acute respiratory distress syndrome (ARDS), also known as respiratory distress syndrome (RDS) or adult respiratory distress ... Doctors and Medical Specialists for Adult respiratory distress syndrome. *Cure Research for Adult respiratory distress syndrome ...
... mechanical ventilation for respiratory failure associated with adult respiratory distress syndrome. Repeat blood films on the ... On hospital day 3, he experienced acute renal failure, adult respiratory distress syndrome, and severe anemia (hemoglobin: 6.3 ... His illness was diagnosed as adult respiratory distress syndrome, and his antimalarial treatment was changed to intravenous ... He experienced respiratory failure and refractory hypotension on hospital day 4. He was treated with mechanical ventilation and ...
... of patients who developed the syndrome had been intubated and placed on mechanical ventilation. Fifty-seven of the 88 patients ... Adult respiratory distress syndrome: risk with common predispositions.. Fowler AA, Hamman RF, Good JT, Benson KN, Baird M, ... 936 patients who had one predisposition and 57 who had several predispositions to the adult respiratory distress syndrome. From ... A highly significant difference (p less than 0.0001) was found in the incidence rates of the syndrome between patients with one ...
... or develop this syndrome postoperatively. The incidence of ARDS in the postoperative period is... ... Patients undergoing emergency surgery may present with the acute respiratory distress syndrome (ARDS) ... Mechanical ventilation in adults with acute respiratory distress syndrome. Summary of the experimental evidence for the ... mechanical ventilation in adult patients with acute respiratory distress syndrome. Am J Respir Crit Care Med. 2017;195:1253-63. ...
... membrane oxygenation versus mechanical ventilation alone in adults with severe acute respiratory distress syndrome: A ... Therapeutic efficacy, mechanical ventilation, length of hospital stay, and mortality rate in severe COVID-19 patients treated ... Baseline CHA2 DS2 -VASc Score and prognosis in octogenarians with Non-ST segment Elevation Acute Coronary Syndrome. February 10 ... Sex-based difference in anticoagulated patients with mechanical prosthetic heart valves and long-term mortality risk. February ...
Recruitment manoeuvres for adults with acute respiratory distress syndrome receiving mechanical ventilation Cochrane Systematic ... Recruitment manoeuvres involve transient elevations in airway pressure applied during mechanical ventilation to open (recruit ... Upper gastrointestinal haemorrhage affects 50 to 150 per 100,000 adults per year, with a high mortality. Red blood cell ... collapsed lung units and increase the number of alveoli participating in tidal ventilation. Recruitment manoeuvres are often u ...
During her hospitalization, she was diagnosed with adult respiratory distress syndrome and required mechanical ventilation. She ... On March 21, adult respiratory distress syndrome and hypoglycemia developed in the woman. Two days later, pyrimethamine- ... During her hospitalization, she was diagnosed with adult respiratory distress syndrome and cardiac arrhythmia, the latter of ... and findings on his chest radiograph were consistent with adult respiratory distress syndrome. He was treated with intravenous ...
Eventually, cold shock brings multisystem failure-pulmonary edema, adult respiratory distress syndrome, liver and kidney ... intubation and mechanical ventilation may be indicated. Positive end-respiratory pressure can help to push fluid out of the ... which is vital to preventing complications of pulmonary edema and adult respiratory distress syndrome. You can expect to ... Whatever its cause, the high respiratory rate can cause a profound respiratory alkalosis that counterbalances lactic acidemia ...
... be admitted to the ICU for respiratory failure, and receive mechanical ventilator therapy. The in-ICU mortality was ... However, risk factors for acute respiratory distress syndrome (ARDS) during neutropenia recovery in patients with hematologic ... Tate RM, Repine JE: Neutrophils and the adult respiratory distress syndrome. Am Rev Respir Dis 1983, 128: 552-559.View Article ... Crawford SW, Schwartz DA, Petersen FB, Clark JG: Mechanical ventilation after marrow transplantation. Risk factors and clinical ...
Lungs & airways , Respiratory distress syndrome , Acute respiratory distress syndrome. Lungs & airways , Ventilation in peri- ... Uncontrolled studies in adults have shown improvements in gas exchange and lung compliance with partial liquid ventilation. A ... ventilation for mechanical ventilation of severely ill children with acute lung injury and acute respiratory distress syndrome ... Acute lung injury and acute respiratory distress syndrome are syndromes of severe respiratory failure. Children with acute lung ...
Scandinavian clinical practice guideline on mechanical ventilation in adults with the acute respiratory distress syndrome. Acta ... Prone positioning in severe acute respiratory distress syndrome. N Engl J Med 2013;368:2159-68. ... Managing the Respiratory care of patients with COVID-19. Italian Thoracic Society and Italian Respiratory Society, 2020:1-17. ... continuous positive airway pressure or mechanical ventilation are needed. The only medical treatments currently being used are ...
Adult respiratory distress syndrome developed in the patient, and he required mechanical ventilation. Our experiences with thi ... Adult Anti-Bacterial Agents Dispatch Doxycycline Ehrlichia Chaffeensis Ehrlichiosis Humans Immunocompromised Host Lung ... The manifestations of human monocytic ehrlichiosis range from a mild febrile syndrome to a severe multisystem illness. ...
  • Patients at risk for Acute Respiratory Distress Syndrome (ARDS) will be enrolled and randomized to one of two groups. (centerwatch.com)
  • We hypothesized that use of HFPV in patients at risk for the development of ARDS will decrease the rate of ventilator associated pneumonia when compared to patients managed with conventional ventilation. (centerwatch.com)
  • We hypothesize that patients with Acute Lung Injury (ALI )and/or Acute Respiratory Distress Syndrome (ARDS) managed primarily with HFPV will have fewer ventilators days, fewer infectious complications, and shorter ICU/hospital lengths of stay than patients managed with conventional mechanical ventilation techniques, while maintaining similar oxygenation (PaO2), ventilation (PaCO2), metabolic (pH), and hemodynamic (cardiac output) parameters. (centerwatch.com)
  • This multicentric prospective clinical practice study aims at evaluating clinical factors associated with a prolonged invasive mechanical ventilation and other outcomes such as mortality and ICU length of stay in patients affected from COVID-19 related pneumonia and ARDS. (clinicaltrials.gov)
  • Acute respiratory distress syndrome (ARDS) is a form of severe lung damage. (denverhealth.org)
  • Acute respiratory distress syndrome (ARDS) is a condition characterized by a high permeability oedema due to loss of the integrity of the alveolo-capillary barrier with impairment of normal surfactant function, resulting in an increased collapse tendency of the alveoli. (biomedsearch.com)
  • These data suggest that the interaction between surfactant changes and mechanical ventilation may play a role in the transition of ARDS into the systematic inflammatory disease process of multiple system organ failure (MSOF). (biomedsearch.com)
  • Perform a pilot study of quality improvement interventions for critical care physicians (intensivists) and respiratory therapists (RTs) to improve application of low tidal volume mechanical ventilation (LTVV) for patients with the acute respiratory distress syndrome (ARDS) using the computerized mechanical ventilation protocols currently available in the investigator's Cerner electronic health record (EHR). (clinicaltrials.gov)
  • Acute respiratory distress syndrome ( ARDS ), also known as respiratory distress syndrome ( RDS ) or adult respiratory distress syndrome (in contrast with IRDS ) is a serious reaction to various forms of injuries to the lung . (rightdiagnosis.com)
  • ARDS formerly most commonly signified adult respiratory distress syndrome to differentiate it from infant respiratory distress syndrome in premature infants. (rightdiagnosis.com)
  • However, as this type of pulmonary edema also occurs in children, ARDS has gradually shifted to mean acute rather than adult . (rightdiagnosis.com)
  • Patients undergoing emergency surgery may present with the acute respiratory distress syndrome (ARDS) or develop this syndrome postoperatively. (springer.com)
  • The development of ARDS as a postoperative pulmonary complication (PPC) is associated with prolonged hospitalisation, longer duration of mechanical ventilation, increased intensive care unit length of stay and high morbidity and mortality Ball et.al (Curr Opin Crit Care 22:379-85, 2016). (springer.com)
  • In order to mitigate the risk of ARDS after surgery, the anaesthetic management and protective mechanical ventilation strategies play an important role. (springer.com)
  • However, risk factors for acute respiratory distress syndrome (ARDS) during neutropenia recovery in patients with hematologic malignancies have not been studied. (biomedcentral.com)
  • Compared with non-ARDS patients, patients who experienced ARDS during neutropenia recovery were more likely to have pneumonia, be admitted to the ICU for respiratory failure, and receive mechanical ventilator therapy. (biomedcentral.com)
  • Acute Respiratory Distress Syndrome (ARDS) also known as, adult respiratory distress syndrome (previously non-cardiogenic pulmonary edema) is a syndrome of acute respiratory failure characterized by bilateral diffuse alveolar infiltrates on chest radiography and resulting hypoxemia. (renalandurologynews.com)
  • This disease usually starts with symptoms beginning within one week of an injury or insult to the body and can only be declared as ARDS if cardiogenic pulmonary edema, fluid overload, and any other cause of the acute respiratory failure can be excluded. (renalandurologynews.com)
  • Are seriously ill patients developing a secondary, bacterial pneumonia, sepsis or Adult Respiratory Distress Syndrome (ARDS)? (blogspot.com)
  • Acute respiratory distress Syndrome (ARDS) was first described in 1967 by Asbough et al. (springer.com)
  • Whereas the use of extracorporeal membrane oxygenation (ECMO) significantly increased the survival rate of neonates with severe acute respiratory failure up to 85%, the world wide mortality rate of children with severe ARDS and extracorporeal lung support is still 50% (ELSO report 07/95) [9]. (springer.com)
  • Inhaled NO is a selective pulmonary vasodilator, 1 2 and in acute respiratory distress syndrome (ARDS), it improves gas exchange. (ahajournals.org)
  • The pressure-volume (P/V) curve has been proposed as a tool to adjust the ventilatory settings in cases of acute respiratory distress syndrome (ARDS). (ebscohost.com)
  • This document provides evidence-based clinical practice guidelines on the use of mechanical ventilation in adult patients with acute respiratory distress syndrome (ARDS). (ebscohost.com)
  • Assessment of oxygenation response to prone position ventilation in ARDS by lung ultrasonography. (ebscohost.com)
  • The article discusses acute respiratory distress syndrome (ARDS) which can be only treated in the intensive care unit with the help of mechanical ventilation. (ebscohost.com)
  • The author opines on a study on managing acute respiratory distress syndrome (ARDS) with non-invasive ventilation by G. Bellani and others. (ebscohost.com)
  • Acute Respiratory Distress Syndrome (ARDS) is an acute inflammatory response of the lung to stressful pulmonary or extrapulmonary processes [ 1 ]. (hindawi.com)
  • Recent Examples on the Web Thousands of Covid-19 survivors have developed ARDS, or acute respiratory distress syndrome , which allows fluid to leak into the lungs. (merriam-webster.com)
  • When patients with lung failure began to fill ICUs 1 year ago, many physicians fell back on years of experience with acute respiratory distress syndrome (ARDS), a life-threatening buildup of fluid in lungs damaged by trauma or infection. (merriam-webster.com)
  • In the last few years prone positioning has been used increasingly in the treatment of patients with acute respiratory distress syndrome (ARDS) and this manoeuvre is now considered a simple and safe method to improve oxygenation. (ersjournals.com)
  • Acute respiratory distress syndrome (ARDS) is characterised by radiographical diffuse bilateral infiltrates, decreased respiratory compliance, small lung volumes and severe hypoxaemia. (ersjournals.com)
  • Since the majority of animal and human studies investigating the physiological effects of prone positioning refer to acute ARDS, the considerations discussed later apply only to the early stages of the syndrome. (ersjournals.com)
  • It is a form of lung injury that can progress to adult respiratory distress syndrome (ARDS). (bmj.com)
  • Acute respiratory distress syndrome or ARDS is a life threatening reaction in adults to injury or infection to the lungs. (wisegeek.com)
  • Mechanical ventilation is generally needed in serious cases of ARDS and is used while the underlying cause is fixed. (wisegeek.com)
  • Using mechanical ventilation may unfortunately lead to ARDS in some cases. (wisegeek.com)
  • Acute respiratory distress syndrome (ARDS) is a rapidly progressive disorder that initially manifests as dyspnea, tachypnea, and hypoxemia, then quickly evolves into respiratory failure. (aafp.org)
  • 1 Acute lung injury is a slightly less severe syndrome characterized by less profound hypoxemia but otherwise similar diagnostic criteria to ARDS. (aafp.org)
  • When mechanical ventilation is required, patients with ARDS should be started at lower tidal volumes (6 mL per kg) instead of at traditional volumes (10 to 15 mL per kg). (aafp.org)
  • Higher positive end-expiratory pressure values (12 to 18 or more cm H 2 O) should be considered for initial mechanical ventilation in patients with ARDS. (aafp.org)
  • Surfactant therapy does not improve mortality in adults with ARDS. (aafp.org)
  • Amato MBP, Barbas CSV, Medeiros DM, et al (1995) Beneficial effects of the "open lung approach" with low distending pressures in ARDS: A prospective randomized study on mechanical ventilation. (springer.com)
  • A 17 year old boy developed adult respiratory distress syndrome (ARDS) due to paraquat poisoning. (bmj.com)
  • 1 We report the perioperative management of a patient who developed adult respiratory distress syndrome (ARDS) after paraquat ingestion. (bmj.com)
  • The current standards of care for adults with the Acute Respiratory Distress Syndrome (ARDS) encompass a variety of processes that are best delivered with an integrated and protocolized approach. (legacyhealth.org)
  • ECMO, as a therapy for ARDS in adults has been controversial for many years but current research indicates that ECMO is a standard of care in the modern treatment regimen for adults with severe ARDS. (legacyhealth.org)
  • We utilize ECMO when indicated as a routine aspect of our protocolized approach to ARDS when other means of oxygenation and/or ventilation are insufficient or less safe. (legacyhealth.org)
  • The early reports of Zapol and Morris, in 1979 and 1992 respectively, showed no benefit to ECMO for adult ARDS, but these studies utilized protocols and equipment that are obsolete. (legacyhealth.org)
  • More recent reports from the UK have demonstrated that outcomes are significantly improved with both adult ARDS 2 and H1N1 pneumonia 3 if patients are cared for in an ECMO center. (legacyhealth.org)
  • In addition, by our protocolized approach to these patients including the dynamic application of the VDR, we have demonstrated a significantly shortened time on ECMO for both adults with ARDS 6 as well as those with H1N1 pneumonia 7 in comparison to the ELSO registry. (legacyhealth.org)
  • Acute respiratory distress syndrome (ARDS) is a type of respiratory failure characterized by rapid onset of widespread inflammation in the lungs. (wikipedia.org)
  • Although the terminology of "adult respiratory distress syndrome" has at times been used to differentiate ARDS from "infant respiratory distress syndrome" in newborns, the international consensus is that "acute respiratory distress syndrome" is the best term because ARDS can affect people of all ages. (wikipedia.org)
  • This complication typically occurs due to the restriction of the blood vessel due to inflammation of the mechanical ventilation There are direct and indirect causes of ARDS depending whether the lungs are initially affected. (wikipedia.org)
  • ARDS is more common in adults over the age of 65 years. (memorialhospitaljax.com)
  • Available at: http://www.dynamed.com/topics/dmp~AN~T113803/Acute-respiratory-distress-syndrome-ARDS. (memorialhospitaljax.com)
  • Therefore, the current approach to mechanical ventilation of a patient with ARDS emphasizes the use of lower tidal volumes with lower pressures to avoid causing lung overdistension and ventilator associated lung injury. (bioportfolio.com)
  • Nevertheless, one year after publication of the ARDSnet trial, Rubenfeld et al noted that lung-protective ventilation strategies were applied in less than 5% of patients with ARDS or ALI at a single ARDSnet center. (bioportfolio.com)
  • Rubenfeld et al found that common barriers to the initiation of low tidal volume ventilation include unwillingness to relinquish control of the ventilator, failure to recognize patients as having ALI/ARDS, and perceived contraindications to low tidal volume ventilation. (bioportfolio.com)
  • The investigators perform a prospective single-center study to investigate the factors associated with the use of lung protective ventilation strategy (LPV) in ALI/ARDS patients in ICU. (bioportfolio.com)
  • The syndrome, initially called acute respiratory distress in adult and is now named as the acute respiratory distress syndrome (ARDS). (bioportfolio.com)
  • Background Preclinical studies suggest that exogenous surfactant may be of value in the treatment of the acute respiratory distress syndrome (ARDS), and two phase 2 clinical trials have shown a trend toward benefit. (ovid.com)
  • We conducted two phase 3 studies of a protein-containing surfactant in adults with ARDS. (ovid.com)
  • Acute respiratory distress syndrome (ARDS) is a potentially fatal disease with high mortality. (pubmedcentralcanada.ca)
  • Acute respiratory distress syndrome (ARDS) is common among mechanically ventilated children and accompanies up to 30% of all pediatric intensive care unit deaths. (frontiersin.org)
  • Though ARDS diagnosis is based on clinical criteria, biological markers of acute lung damage have been extensively studied in adults and children. (frontiersin.org)
  • The biochemical signature of ARDS has been increasingly well described in adult populations, and this has led to the identification of molecular phenotypes to augment clinical classifications. (frontiersin.org)
  • Additionally, because of the lower incidence of and mortality from ARDS in pediatric patients relative to adults and lack of robust clinical predictors of outcome, there is an ongoing interest in biological markers as surrogate outcome measures. (frontiersin.org)
  • At least 30% of children require invasive mechanical ventilation, and those who develop the acute respiratory distress syndrome (ARDS) may account for as much as 30% of all PICU mortality ( 1 , 2 ). (frontiersin.org)
  • Comparison of mechanical power estimations in mechanically ventilated patients with ARDS: a secondary data analysis from the EPVent study. (harvard.edu)
  • Necrotizing pneumonia is characterized by rapid, extensive, bilateral pneumonia frequently evolving towards acute respiratory distress syndrome (ARDS), despite intensive medical interventions with mechanical ventilation and inotrope support. (biomedcentral.com)
  • It is associated with classic severity factors, such as the need for mechanical ventilation or inotrope support, and the onset of ARDS. (biomedcentral.com)
  • The pregnant patients are prone to influenza A H1N1 virus infection, which may rapidly progress to lower respiratory tract infection and subsequent respiratory failure and acute respiratory distress syndrome (ARDS). (ebscohost.com)
  • Pneumothorax might develop in ARDS under mechanical ventilation. (ebscohost.com)
  • When severe DAH results in the adult respiratory distress syndrome (ARDS), high levels of FI0 2 and positive end-expiratory pressure (PEEP) are often needed to achieve acceptable oxygenation. (oncologynurseadvisor.com)
  • National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network. (bmj.com)
  • Objective To determine surfactant profiles of tracheal secretions in mechanically ventilated children with respiratory failure secondary to bacterial pneumonia, viral pneumonitis, adult respiratory distress syndrome (ARDS), and cardiopulmonary bypass. (ovid.com)
  • BACKGROUND: Our objective was to systematically review the effect of pharmacological therapies on mortality in patients with acute respiratory distress syndrome (ARDS), focusing on randomized controlled trials (RCTs) published since a previous review in 2004. (minervamedica.it)
  • We included RCTs of pharmacologic therapies compared with placebo or no therapy for adult patients with ARDS, using authors' definitions, which reported on mortality (≤3 months after randomization). (minervamedica.it)
  • We excluded subgroups of patients with ARDS reported in RCTs enrolling other populations and RCTs of therapies to prevent ARDS, nutritional or fluid interventions, inhaled nitric oxide, therapies coupled to a mechanical ventilation strategy, or oxygen. (minervamedica.it)
  • Similar clinical findings are found in Adult Respiratory Distress Syndrome (ARDS) which often is complicated by a chest injury so, it is better to wait for 24 to 48 hours prior to stabilize the long bone fractures. (amhe.org)
  • To test the hypothesis that mechanical ventilation induces a pulmonary and systemic cytokine response that can be minimized by limiting recruitment or derecruitment and overdistention. (nih.gov)
  • Because experimental studies have shown that intact alveolar epithelial fluid transport function is critical for resolution of pulmonary edema and acute lung injury, we measured net alveolar fluid clearance in 79 patients with acute lung injury or the acute respiratory distress syndrome. (nih.gov)
  • In summary, in contrast to hydrostatic pulmonary edema, alveolar fluid clearance in patients with acute lung injury and the acute respiratory distress syndrome is impaired in the majority of patients, and maximal alveolar fluid clearance is associated with better clinical outcomes. (nih.gov)
  • Acute respiratory distress syndrome is a pulmonary disease that requires the use of mechanical ventilation for patient recovery. (ebscohost.com)
  • In an earlier clinical trial in Wuhan, China, where the coronavirus outbreak began, it was noted that death from the disease is frequently the result of an abnormal pulmonary immune system response with multiple respiratory viral infections in which there is an elevation of cytokine and chemokine production referred to as a " cytokine storm " and associated with poor clinical outcomes. (news-medical.net)
  • Acute respiratory distress syndrome is believed to occur when a pulmonary or extrapulmonary insult causes the release of inflammatory mediators, promoting neutrophil accumulation in the microcirculation of the lung. (aafp.org)
  • High frequency jet ventilation was applied on the left lung until clamping of the pulmonary artery. (bmj.com)
  • Although respiratory compliance and arterial oxygen tension were markedly improved, the pulmonary artery pressure remained elevated at 37 mm Hg. (bmj.com)
  • Prolonged mechanical ventilation has the potential to aggravate or initiate pulmonary inflammation and cause lung damage through fibrin deposition. (biomedcentral.com)
  • INTRODUCTION: Experience with high-frequency oscillatory ventilation (HFOV) after congenital cardiac surgery is limited despite evidence about reduction in pulmonary vascular resistance after the Fontan procedure. (biomedsearch.com)
  • And it's also proving to be very beneficial for infants and children experiencing hypoxic respiratory failure, respiratory distress syndrome, and pulmonary hypertension. (secondopinionnewsletter.com)
  • As in adults, acute lung injury (ALI) in children occurs as a consequence of various direct (e.g., infectious pneumonia, bronchiolitis, aspiration, traumatic lung contusion) or indirect (e.g., sepsis, shock, massive blood transfusion, non-pulmonary trauma) injuries to the lung. (frontiersin.org)
  • For example, senescent rodent lungs are more susceptible to lung injury in the setting of mechanical ventilation, ozone exposure, and pulmonary infection [ 6 - 10 ]. (hindawi.com)
  • By far the most common extrapulmonary feature is acute glomerulonephritis (GN), and the presence of DAH with GN is sometimes referred to as the pulmonary-renal syndrome. (oncologynurseadvisor.com)
  • The three major categories of the pulmonary-renal syndrome (DAH with GN) are 1) antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis, 2) anti-glomerular basement membrane antibody (AGBMA) disease (Goodpasture's syndrome), and systemic lupus erythematosus (SLE). (oncologynurseadvisor.com)
  • Butler developed acute respiratory distress syndrome , a severe complication of COVID-19 pneumonia. (merriam-webster.com)
  • Sophie Carson, Milwaukee Journal Sentinel , "Diane Butler, who carried her family on her shoulders, fell to COVID in 2020," 10 Mar. 2021 His official cause of death, on April 1, was COVID-19-related pneumonia and acute respiratory distress syndrome . (merriam-webster.com)
  • Cristin Flanagan, Bloomberg.com , "Novartis Invests in Stem Cell Therapy for Covid," 20 Nov. 2020 His sister Angeli was put under a hospital ventilator before dying, according to her death certificate, of acute respiratory distress syndrome , pneumonia and metastatic lung cancer. (merriam-webster.com)
  • According to guidelines from the American Thoracic Society (ATS) and the Infectious Disease Society of America (IDSA), posteroanterior (PA) chest radiographs should be obtained if pneumonia is suspected in adults. (medscape.com)
  • Radiologic findings of adult viral pneumonia are variable and overlapping. (medscape.com)
  • Most cases of acute respiratory distress syndrome are associated with pneumonia or sepsis. (aafp.org)
  • Acute respiratory distress syndrome often has to be differentiated from congestive heart failure, which usually has signs of fluid overload, and from pneumonia. (aafp.org)
  • The clinical syndrome is associated with pathological findings including pneumonia, eosinophilic pneumonia, cryptogenic organizing pneumonia, acute fibrinous organizing pneumonia, and diffuse alveolar damage (DAD). (wikipedia.org)
  • Aging is associated with increased incidence of respiratory disorders, and elderly patients represent a disproportionate number of afflicted individuals with pneumonia, acute lung injury, and lung fibrosis, among other lung disorders [ 1 - 5 ]. (hindawi.com)
  • Necrotizing pneumonia attributed to Panton-Valentine leukocidin-positive Staphylococcus aureus has mainly been reported in otherwise healthy children and young adults, with a high mortality rate. (biomedcentral.com)
  • Although often a life-saving technique, mechanical ventilation carries many potential complications including pneumothorax, airway injury, alveolar damage, and ventilator-associated pneumonia, among others. (bionity.com)
  • Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China. (bmj.com)
  • Studies have shown that an inflammatory response may be elicited by mechanical ventilation used for recruitment or derecruitment of collapsed lung units or to overdistend alveolar regions, and that a lung-protective strategy may reduce this response. (nih.gov)
  • Mechanical ventilation on such alveoli with repeated alveolar collapse and subsequent reexpansion results in severe lung parenchymal injury and may induce further surfactant impairment. (biomedsearch.com)
  • Patients with maximal alveolar fluid clearance had significantly lower mortality and a shorter duration of mechanical ventilation. (nih.gov)
  • There may also be a reduction in mechanical factors associated with VALI, such as an inhomogeneous distribution of pleural pressure ( P pl ), alveolar inflation and ventilation, an increase in lung volume and reduction in atelectatic lung regions and, finally, an improvement in clearance of secretions. (ersjournals.com)
  • Before describing the mechanisms by which the prone position improves oxygenation, the physiology of the distribution of alveolar inflation, alveolar ventilation and perfusion is discussed. (ersjournals.com)
  • It is not a therapeutic endpoint, but rather the penalty we have to pay for decreasing alveolar ventilation when we give priority to the limitation of lung overdistension. (springer.com)
  • median BW 2950g, range 2610-4360), 2) diffuse alveolar disease radiographically, 3) requiring FiO 2 1.0 and mechanical ventilation to maintain paO 2 50, 4) absence of other conditions known to produce a similar clinical profile. (nature.com)
  • DeBruin W, Notterman DA, Magid M et al (1992) Acute hypoxemic respiratory failure in infants and children: Clinical and pathologic characteristics. (springer.com)
  • Severe hypoxemic respiratory failure: part 1--ventilatory strategies. (medscape.com)
  • Severe DAH can rapidly lead to fulminant hypoxemic respiratory failure and may be fatal. (oncologynurseadvisor.com)
  • The most immediate life-threatening complication of DAH is acute hypoxemic respiratory failure. (oncologynurseadvisor.com)
  • His clinical projects include the use of inhaled nitric oxide, clinical utility of various forms of mechanical ventilation, clinical toxicology, and hazardous material spill incidents. (healthlinkbc.ca)
  • New insights into the pathophysiology of acute chest syndrome (ACS) have highlighted potential therapeutic strategies including the use of nitric oxide. (bmj.com)
  • However, despite treatment with intravenous antibiotics, corticosteroid, and inhaled nitric oxide (NO), the patient's respiratory condition progressively deteriorated. (bmj.com)
  • Within 72 hours of onset of predisposition, 89.5% of patients who developed the syndrome had been intubated and placed on mechanical ventilation. (nih.gov)
  • The use of partial liquid ventilation to decrease the number of deaths and illness in children with acute onset respiratory failure is not supported by evidence from randomized controlled trials. (cochrane.org)
  • Streptococcal toxic shock syndrome is a clinical entity that is often associated with a rapid onset shock like state and multiorgan system failure. (renalandurologynews.com)
  • Interestingly, there's a somewhat unique loss of smell and taste in some individuals that precede the onset of respiratory symptoms,' Fauci explained. (yahoo.com)
  • Patients with acute respiratory failure exhibiting decreased respiratory system compliance with hypoxemia or carbon dioxide retention are often difficult to ventilate with current guidelines that limit applied plateau pressure Yet, these guidelines do not take into consideration chest wall mechanics. (clinicaltrials.gov)
  • The investigators sought to determine whether partition of the respiratory system into its components by measuring esophageal pressure and thus assessment of pleural pressure, would help in patients with acute respiratory failure to identify the factors contributing to low respiratory system compliance. (clinicaltrials.gov)
  • Goal Directed Mechanical Ventilation Aimed at Optimal Lung Compliance Approach Guided by Esophageal Pressure in Acute Respiratory Failure. (clinicaltrials.gov)
  • Esophageal balloon will be inserted, and esophageal pressure will be measured in patients with acute respiratory failure. (clinicaltrials.gov)
  • Babesiosis can also be associated with severe complications that include renal failure ( 9 , 10 ), disseminated intravascular coagulation ( 9 ), and adult respiratory distress syndrome ( 1 , 9 , 10 ). (cdc.gov)
  • and whether ICU admission was for acute respiratory failure, shock, coma, or acute renal failure. (biomedcentral.com)
  • Moler FW, Custer JR, Bartlett R et al (1994) Extracorporeal life support for severe pediatric respiratory failure: An updated experience 1991-1993. (springer.com)
  • Noninvasive mechanical ventilation is an effective technique for the management of patients with acute or chronic respiratory failure. (indigo.ca)
  • Although this illustrative case with a typical presentation of ACS had a favourable outcome, the question is raised of whether anything could have been done to avoid respiratory failure. (bmj.com)
  • Octapharma USA is supporting a new investigator initiated clinical trial led by George Sakoulas, M.D. of Sharp Memorial Hospital in San Diego, California focused on treating the most critical patients at the heart of the coronavirus pandemic, those experiencing respiratory failure who become ventilator dependent. (news-medical.net)
  • Epidemiology and outcome of acute respiratory failure in intensive care unit patients. (semanticscholar.org)
  • Perret C, Feihl F (1992) Respiratory failure in asthma: management of the mechanically ventilated patient. (springer.com)
  • Bidani A, Tzouanakis AE, Cardenas VJ Jr, Zwischenberger JB (1994) Permissive hypercapnia in acute respiratory failure. (springer.com)
  • Although ventilator dependence has traditionally been regarded as a relative contraindication for lung transplantation, candidates who deteriorate while on a waiting list and patients who develop acute respiratory failure in the absence of any associated organ dysfunction represent unique situations that merit cautious examination. (bmj.com)
  • STudy of Alteplase for Respiratory failure in SARS-Cov2/COVID-19: Study Design of the Phase IIa STARS Trial. (harvard.edu)
  • This study prospectively compared the organ system failure (OSF), the acute physiology and chronic health evaluation (APACHE) II, and the APACHE III, scores on patients requiring mechanical ventilation in the medical intensive care unit, to predict outcome. (bmj.com)
  • The factors that independently predicted outcome among these patients on mechanical ventilation were the type of respiratory failure (type I) OR = 2.7 (p = 0.02), the use of inotropes OR 2.4 (p = 0.04), and the APACHE II score OR = 1.8 (p = 0.008) for every five point increase in APACHE II score. (bmj.com)
  • Type 1 respiratory failure, the use of inotropes, and the APACHE II score measured at admission are significant independent predictors of mortality in the patients on mechanical ventilation. (bmj.com)
  • We prospectively compared the three scoring systems to predict clinical outcome: the organ system failure (OSF), the acute physiology and chronic health evaluation (APACHE) II, and the APACHE III scores along with other variables that could possibly have a relation to outcome in patients requiring mechanical ventilation in the medical intensive care unit (MICU) in a tertiary care centre in India. (bmj.com)
  • Severe DAH can lead to acute respiratory failure and death. (oncologynurseadvisor.com)
  • The most important aspect of initial assessment is to determine the need for intubation and mechanical ventilatory support because of established or impending respiratory failure. (oncologynurseadvisor.com)
  • Patients One hundred twenty pediatric patients with respiratory failure requiring mechanical ventilation. (ovid.com)
  • Low frequency positive pressure ventilation with extracorporeal CO2 removal (LEPPV-ECCO2R) in acute respiratory failure (ARF): technique. (semanticscholar.org)
  • Reversal of terminal acute respiratory failure by low frequency positive pressure ventilation with extracorporeal removal of CO2 (LFPPV-ECCO2R). (semanticscholar.org)
  • Treatment of acute respiratory failure with low-frequency positive-pressure ventilation and extracorporeal removal of CO2. (semanticscholar.org)
  • Extracorporeal membrane oxygenation in severe acute respiratory failure. (semanticscholar.org)
  • In the absence of consensus and established guidelines for mechanical ventilation in children with ALI, we believe that the daily clinical practice in pediatric intensive care units is subject to great variations according to the experience, comfort and knowledge of the attending intensivist. (clinicaltrials.gov)
  • Design: An international cross-sectional epidemiologic study in Pediatric Intensive Care Units on the observed practice pattern of invasive and non-invasive mechanical ventilation in children with ALI. (clinicaltrials.gov)
  • This guideline provides recommendations to support hospital clinicians managing critically ill adults with COVID-19 in the intensive care unit (ICU). (helsebiblioteket.no)
  • So it usually requires mechanical ventilation and admission to an intensive care unit . (rightdiagnosis.com)
  • Lyrene RK, Truog WE (1981) Adult respiratory distress syndrome in a pediatric intensive care unit: Predisposing conditions, clinical course, and outcome. (springer.com)
  • Eligibility criteria Prospective randomised clinical trials of adults with sepsis of any severity (with or without baseline hypoalbuminaemia) in critical or intensive care who received pooled human albumin solutions as part of fluid volume expansion and resuscitation (with or without improvement of hypoalbuminaemia) compared with those who received control fluids (crystalloid or colloid), were included if all-cause mortality outcome data were available. (bmj.com)
  • Results Eighteen articles reporting on 16 primary clinical trials that included 4190 adults in critical or intensive care with sepsis, severe sepsis, or septic shock. (bmj.com)
  • An Official American Thoracic Society/European Society of Intensive Care Medicine/Society of Critical Care Medicine Clinical Practice Guideline: Mechanical Ventilation in Adult Patients with Acute Respiratory Distress Syndrome. (ebscohost.com)
  • Clinical applications are then considered in depth in a series of chapters that address the use of noninvasive mechanical ventilation in chronic settings and in critical care, both within and outside of intensive care units. (indigo.ca)
  • It is estimated that 7.1 percent of all patients admitted to an intensive care unit and 16.1 percent of all patients on mechanical ventilation develop acute lung injury or acute respiratory distress syndrome. (aafp.org)
  • The aim of the present study was to assess associations between commencement of HFOV on the day of surgery and length of mechanical ventilation, length of Intensive Care Unit (ICU) stay and mortality in neonates and infants with respiratory distress following cardiac surgery. (biomedsearch.com)
  • 200 consecutive patients requiring mechanical ventilation in a medical intensive care unit were recruited. (bmj.com)
  • Mechanical ventilation is an essential life support given to many patients in the intensive care unit (ICU). (bmj.com)
  • Incidence and recognition of acute respiratory distress syndrome in a UK intensive care unit. (bmj.com)
  • Effects of MMP-9 inhibition by doxycycline on proteome of lungs in high tidal volume mechanical ventilation-induced acute lung injury. (ebscohost.com)
  • Akilah Johnson, ProPublica , "How COVID-19 Hollowed Out a Generation of Young Black Men," 22 Dec. 2020 In the most serious cases, COVID progresses to acute respiratory distress syndrome , where fluid accumulates in the air sacs of the lungs, impeding their ability to provide oxygen to the body. (merriam-webster.com)
  • After a cold ischaemia time of 270 minutes the donor lung was reperfused and conventional mechanical ventilation was resumed on both lungs with the application of a PEEP of 5 cm H 2 O. Weaning from cardiopulmonary bypass was successful with inotropic support (epinephrine 0.1 μg/kg/min). (bmj.com)
  • Inflammation and fluid in the lungs leads to an advanced pneumonialike condition called adult respiratory distress syndrome, the most common cause of death in septic shock. (deseretnews.com)
  • Other therapeutic measures may include drugs to constrict dilated blood vessels, and mechanical ventilation to help keep the lungs functioning. (deseretnews.com)
  • They were also less likely (8 percent compared to 2 percent) to experience acute respiratory distress syndrome, a condition where the lungs begin to fill up with fluid and which is oftentimes fatal or permanently debilitating. (medicaldaily.com)
  • The main form of mechanical ventilation currently is positive pressure ventilation, which works by increasing the pressure in the patient's airway and thus forcing additional air into the lungs. (bionity.com)
  • Severely ill children can develop lung disease, called acute lung injury or acute respiratory distress syndrome, which stops sufficient oxygenation of the blood. (cochrane.org)
  • Improved oxygenation and lower peak airway pressure in severe adult respiratory distress syndrome. (wikipedia.org)
  • The physiological effects of prone positioning in patients with severe lung injury manifest as improvements in oxygenation and respiratory mechanics. (ersjournals.com)
  • Should We Use Non-invasive Ventilation to Treat Acute Respiratory Distress Syndrome? (ebscohost.com)
  • Lauren Caruba, ExpressNews.com , "San Antonio's first double lung transplant for COVID-19 performed at University Hospital," 24 Nov. 2020 The stem cell therapy is being developed to treat acute respiratory distress syndrome , a complication often seen in advanced Covid-19 patients. (merriam-webster.com)
  • Extracorporeal circulatory approaches to treat acute respiratory distress syndrome. (semanticscholar.org)
  • Thus, instead of limiting mechanical ventilation by plateau pressure, PEEP and Inspiratory pressure adjustment would be individualized specifically for each patient's lung compliance as indicated by transpulmonary pressure. (clinicaltrials.gov)
  • In a study of 14 patients undergoing mechanical ventilation with PC-IRV, the incidence of pneumothorax was 29 percent despite the lack of measurable auto-PEEP. (wikipedia.org)
  • Adult diagnosis is based on a PaO2/FiO2 ratio (ratio of partial pressure arterial oxygen and fraction of inspired oxygen) of less than 300 mm Hg despite a positive end-expiratory pressure (PEEP) of more than 5 cm H2O. (wikipedia.org)
  • A trial of PEEP ≥6 cm H 2 O should be considered in full-term infants with severe respiratory distress in whom other causes can be excluded. (nature.com)
  • Therapeutic efficacy, mechanical ventilation, length of hospital stay, and mortality rate in severe COVID-19 patients treated with tocilizumab. (medscape.com)
  • USA Today , "How the South and Southwest became the global epicenter of the COVID-19 pandemic," 10 Dec. 2020 Both viruses can cause people to develop acute respiratory distress syndrome , but the researchers explained that this syndrome is more common in COVID-19 patients than in flu patients, and that this may explain the higher mortality rate. (merriam-webster.com)
  • 2 Poor outcomes primarily are associated with the increasing severity of disease, with a mortality rate as high as 20 percent occurring primarily in patients who require mechanical ventilation. (aafp.org)
  • Hickling KG, Walsh J, Henderson S, Jackson R (1994) Low mortality rate in adult respiratory distress syndrome using low-volume, pressure-limited ventilation with permissive hypercapnia: a prospective study. (springer.com)
  • However, despite advances in ventilator management, the mortality rate of acute lung injury and the acute respiratory distress syndrome remains very high (approximately 40 to 50 percent). (bioportfolio.com)
  • Our hypothesis is that daily clinical practice is heterogenous among pediatric intensivists as few pediatric data exists on optimal mechanical ventilation strategies in this group of patients. (clinicaltrials.gov)
  • INTRODUCTION Few pediatric data exists on the ventilation mode and parameters that would provide the greatest benefit with the least risk to an individual pediatric patient with Acute Lung Injury (ALI). (clinicaltrials.gov)
  • METHODS Objective: Describe invasive and non-invasive mechanical ventilation in pediatric cases of ALI. (clinicaltrials.gov)
  • Hypothesis: There is an important variability in the observed practice pattern of mechanical ventilation in pediatric cases of ALI. (clinicaltrials.gov)
  • FUTURE CONSIDERATIONS We believe this study will provide important data on the actual mechanical ventilation strategies in pediatric patients with ALI. (clinicaltrials.gov)
  • Royall JA, Levin DL (1988) Adult respiratory distress syndrome in pediatric patients. (springer.com)
  • The closing chapters examine uses of noninvasive mechanical ventilation in neonatal and pediatric care. (indigo.ca)
  • Jeffrey Bilharz, BS, RRT, RRT-NPS, right, seen here at the OPEN FORUM in Indianapolis with fellow AARC member and Boston Children's colleague Craig Smallwood, BS, RRT, plans to expand on his study of ideal body weight methods for pediatric mechanical ventilation. (aarc.org)
  • Purpose: To study the efficacy of lopinavir-ritonavir and hydroxychloroquine in critically ill patients with coronavirus disease 2019 (COVID-19) Methods: Critically ill adults with COVID-19 were randomized to receive lopinavir-ritonavir, hydroxychloroquine, combination therapy of lopinavir-ritonavir, and hydroxychloroquine or no antiviral therapy (control). (imperial.ac.uk)
  • Loss of aerated lung tissue subsequently leads to hypoxemia and ventilation-perfusion abnormalities. (renalandurologynews.com)
  • Acute respiratory distress syndrome manifests as rapidly progressive dyspnea, tachypnea, and hypoxemia. (aafp.org)
  • Adult Respiratory Distress Syndrome    Severe hypoxemia Loss of lung compliance Secondary disease     Reduced perfusion Increased capillary permeability Direct tissue and capillary insult Other mechanism  Despite primary disease. (scribd.com)
  • On February 21th 2020, SARS-CoV-2 outbreak erupted in Italy and, in the immediately subsequent period, all the Italian regional Health Systems had to face with an overwhelming increase of COVID-19 admissions requiring isolation, oxygen, ventilation and ICU beds. (clinicaltrials.gov)
  • Dr. Sakoulas hopes to enroll 20 adults hospitalized with COVID-19 requiring significant oxygen, but not on mechanical ventilation. (news-medical.net)
  • Signs and symptoms may include shortness of breath, fast breathing, and a low oxygen level in the blood due to abnormal ventilation. (wikipedia.org)
  • AH 11 survived but required prolonged mechanical ventilation and supplemental oxygen. (nature.com)
  • Nearly all patients will need supplemental oxygen and many will require intubation and mechanical ventilation. (oncologynurseadvisor.com)
  • One cohort will receive conventional mechanical ventilation adhering to our well defined protocol of protective lung strategies. (centerwatch.com)
  • Due attention is also paid to weaning from conventional mechanical ventilation, potential complications, intraoperative applications, and staff training. (indigo.ca)
  • Hurst JM et al, Comparison of conventional mechanical ventilation and high-frequency ventilation. (slideserve.com)
  • Conventional mechanical ventilation was applied selectively on the right lung with inhaled NO (8-15 ppm). (bmj.com)
  • METHODS: A logistic regression model was used to develop a propensity score, which accounted for the probability of being switched from conventional mechanical ventilation (CMV) to HFOV on the day of surgery. (biomedsearch.com)
  • In addition, it is indicated as a measure to control ventilation in critically ill patients and as prophylaxis for impending collapse of other physiologic functions. (medscape.com)
  • Noninvasive Ventilation Use in Critically Ill Patients with Acute Asthma Exacerbations. (amedeo.com)
  • Nebulized heparin was associated with fewer days of mechanical ventilation in critically ill patients expected to require prolonged mechanical ventilation. (biomedcentral.com)
  • Patients: Patients less than 18 years old on invasive or non-invasive mechanical ventilation with a diagnosis of ALI on the day of the study. (clinicaltrials.gov)
  • These infections should be considered in the differential diagnosis of acute shock syndromes -presenting both with fever and shock, or fever, rash, and shock. (renalandurologynews.com)
  • Toxic shock syndrome caused by Streptococcus pyogenes may initially be indistinguishable from that caused by Staphylococcus aureus, which should also be considered in the differential diagnosis. (renalandurologynews.com)
  • A repeat chest radiograph showed new infiltrates in both lower zones and a diagnosis of acute sickle chest syndrome (ACS) was made. (bmj.com)
  • Towards this end, we recognize the relative roles of ARDSnet pressure control ventilation, airway pressure release ventilation (APRV) and high frequency oscillatory ventilation (HFOV) and the data that supports their selected uses. (legacyhealth.org)
  • High-frequency oscillatory ventilation and short-term outcome in neonates and infants undergoing cardiac surgery: a propensity score analysis. (biomedsearch.com)
  • High-frequency oscillatory ventilation (HFOV) is an established treatment for acute respiratory distress in preterm neonates. (biomedsearch.com)
  • In medicine , mechanical ventilation is a method to mechanically assist or replace spontaneous breathing when patients cannot do so on their own, and must be done so after invasive intubation with an endotracheal or tracheostomy tube through which air is directly delivered (in contrast to non-invasive ventilation). (bionity.com)
  • Simultaneous bilateral spontaneous pneumothorax in an adult patient with cystic fibrosis. (ebscohost.com)
  • A patient with one long bone fracture has 3% chances to develop FES while the one with bilateral femur fractures may develop the syndrome in 33 % of the cases. (amhe.org)
  • Optimizing ventilator strategies may reduce respiratory morbidities in preterm infants. (frontiersin.org)
  • PROTECTIVE-ventilation strategy with tidal volumes of 6 ml/kg or lesser is recommended in patients with acute respiratory distress syndrome for limiting ventilator-induced lung injury. (asahq.org)
  • The outcomes assessed were: overall mortality, ventilator-free days, time of mechanical ventilation, adverse events, changes in gas exchange, in ventilator settings, and in respiratory mechanics. (pubmedcentralcanada.ca)
  • Ventilation/Perfusion scans may demonstrate mottled pattern of sub-segmental perfusion with a normal ventilator pattern. (amhe.org)
  • Child on invasive mechanical ventilation administered through an endotracheal tube or a tracheostomy tube, or on non-invasive mechanical ventilation administered through a nasal or facial mask or a nasal canula or helmet at 9 a.m. on the day of the study. (clinicaltrials.gov)
  • We also noted therapeutic interventions during the stay in the ICU, including mechanical ventilation (MV), vasopressor treatment, dialysis, and administration of granulocyte colony-stimulating factor (G-CSF). (biomedcentral.com)
  • Wozniak DR, Lasserson TJ, Smith I. Educational, supportive and behavioural interventions to improve usage of continuous positive airway pressure machines in adults with obstructive sleep apnoea. (medscape.com)
  • Association between use of lung-protective ventilation with lower tidal volumes and clinical outcomes among patients without acute respiratory distress syndrome: a meta-analysis. (semanticscholar.org)
  • Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome. (medscape.com)
  • Lung- and Diaphragm-Protective Ventilation. (amedeo.com)
  • However, the factors such as comorbidity and pathophysiological change associated with underuse of lung protective ventilation strategy are not clear. (bioportfolio.com)
  • Fifty patients expected to require mechanical ventilation for more than 48 hours were enrolled in a double-blind randomized placebo-controlled trial of nebulized heparin (25,000 U) or placebo (normal saline) 4 or 6 hourly, depending on patient height. (biomedcentral.com)
  • 56 of the most significant conditions are addressed in the care plans, including cardiac surgery, intra-aortic balloon pumping, mechanical ventilation, disseminated intravascular coagulation, multiple organ dysfunction syndrome, latex allergies, burns, and many other commonly encountered diagnoses. (powells.com)
  • To date, it is not clear which clinical, pharmacological and radiologic factors relate to a prolonged duration of mechanical ventilation, mortality and ICU length of stay and it's urgent to understand these aspects in order to develop optimal strategies to allow faster but safe paths for these patients. (clinicaltrials.gov)
  • These treatments, together with common ICU practice aspects such as early/late tracheostomy, ventilatory parameters believed adequate in order to start a weaning procedure, fluidic balance, choice of analgesia and sedation regimens, are not standardized in this particular syndrome due to the lack of evidence available and there is need for information about which factors correlate to a lower duration of mechanical ventilation and mortality. (clinicaltrials.gov)
  • Defined as: % of time each patient is on a compliant tidal volume for the duration of mechanical ventilation. (clinicaltrials.gov)
  • Clinically relevant outcome measures should be assessed ( mortality at discharge and later, duration of both respiratory support and hospital stay, and long-term neurodevelopmental outcomes). (cochrane.org)
  • IRV has not often been shown to improve important clinical outcomes, such as mortality, duration of mechanical ventilation, or duration of ICU stay. (wikipedia.org)
  • Noninvasive Positive Pressure Ventilation Using Continuous Positive Airway Pressure. (indigo.ca)
  • This intervention should not be started without thoughtful consideration because intubation and positive-pressure ventilation are not without potentially harmful effects. (medscape.com)
  • During a multicenter trial of permissive hypercapnia in extremely low birthweight infants (PHELBI), preterm infants (birthweight 400-1,000 g, gestational age 23 0/7-28 6/7 weeks) requiring mechanical ventilation within 24 h of birth were randomly assigned to a high PCO 2 target or a control group. (frontiersin.org)
  • CONCLUSIONS: When commenced on the day of surgery in neonates and infants with respiratory distress following cardiac surgery, HFOV was associated with shorter lengths of mechanical ventilation and ICU stay than CMV. (biomedsearch.com)
  • Ventilators for Noninvasive Mechanical Ventilation. (indigo.ca)
  • Nocturnal Noninvasive Mechanical Ventilation. (indigo.ca)
  • Carbon Dioxide Rebreathing During Noninvasive Mechanical Ventilation. (indigo.ca)
  • The pressure, volume, and flow to time waveforms for airway pressure-release ventilation. (medscape.com)
  • There is no evidence from RCTs to support or refute the use of partial liquid ventilation in children with acute lung injury or acute respiratory distress syndrome. (cochrane.org)
  • To assess whether partial liquid ventilation reduces mortality or morbidity , or both, in children with acute lung injury or acute respiratory distress syndrome. (cochrane.org)
  • Higher vs lower positive end-expiratory pressure in patients with acute lung injury and acute respiratory distress syndrome: systematic review and meta-analysis. (medscape.com)
  • A systematic review and meta-analysis was undertaken, examining the role of magnesium in the management of severe TBI in adults. (readbyqxmd.com)
  • In 1988 an expanded definition was proposed which quantified physiologic respiratory impairment. (rightdiagnosis.com)
  • Physiologic indications include respiratory or mechanical insufficiency and ineffective gas exchange. (medscape.com)
  • The optimal monitoring strategies and outcome measures in adults. (medscape.com)
  • There are scarce data from India validating scoring systems used to predict outcome in patients requiring mechanical ventilation. (bmj.com)
  • The next step will be to conduct a prospective international study on mechanical ventilation strategies and to follow patients prospectively during the whole course of their mechanical ventilation. (clinicaltrials.gov)
  • Epidemiology, clinical course, and outcomes of critically ill adults with COVID-19 in New York City: a prospective cohort study. (doximity.com)
  • This study is designed to exam the effects of early management with high frequency percussive ventilation (HFPV) on patients with lung injury. (centerwatch.com)
  • PALIVE 1 is an observational multicenter study on mechanical ventilation strategies used in children with an acute lung injury (ALI). (clinicaltrials.gov)
  • Background: Although mechanical ventilation (MV) is a major supportive therapy for patients with acute respiratory distress syndrome, it may result in side effects including lung injury. (ebscohost.com)
  • Airway pressures and early barotrauma in patients with acute lung injury and acute respiratory distress syndrome. (semanticscholar.org)
  • Incidence and mortality of acute lung injury and the acute respiratory distress syndrome in three Australian States. (semanticscholar.org)
  • Emerging therapies for treatment of acute lung injury and acute respiratory distress syndrome. (memorialhospitaljax.com)
  • 2. Frutos-Vivar F, Esteban A. Epidemiology of acute lung injury and acute respiratory distress syndrome. (bmj.com)
  • Evidence-based management of acute lung injury and acute respiratory distress syndrome. (semanticscholar.org)
  • To achieve these ends, it is important to select the most appropriate means of ventilatory support, thereby minimising the damaging effects of mechanical ventilation. (ersjournals.com)
  • Currently, ventilatory support using small tidal volumes and low plateau pressures and respiratory rate, to control arterial carbon dioxide tension ( P a,CO 2 ) and pH, are considered optimal 1 . (ersjournals.com)
  • Mechanical ventilatory support was continued for five weeks until a suitable lung donor was found. (bmj.com)
  • Mclntyre RC, Haenel JV, Moore FA, Read RR, Burch JM, Moore EE (1994) Cardiopulmonary effects of permissive hypercapnia in the management of adult respiratory distress syndrome. (springer.com)
  • Mechanisms of acute respiratory distress syndrome: role of surfactant changes and mechanical ventilation. (biomedsearch.com)
  • Modèle expérimental de lapins (n=12) déficients en surfactant. (slideserve.com)
  • 3 groupes de lapins déficients en surfactant. (slideserve.com)
  • Similar events can lead to the infant respiratory distress syndrome (RDS), with surfactant deficiency and lung immaturity as underlying conditions ( 3 ). (frontiersin.org)
  • Hickling KG, Henderson SJ, Jackson R (1990) Low mortality associated with low volume pressure limited ventilation with permissive hypercapnia in severe adult respiratory distress syndrome. (springer.com)