A benzimidazole that acts by interfering with CARBOHYDRATE METABOLISM and inhibiting polymerization of MICROTUBULES.
Substances used in the treatment or control of nematode infestations. They are used also in veterinary practice.
A benzimidazole broad-spectrum anthelmintic structurally related to MEBENDAZOLE that is effective against many diseases. (From Martindale, The Extra Pharmacopoeia, 30th ed, p38)
Agents destructive to parasitic worms. They are used therapeutically in the treatment of HELMINTHIASIS in man and animal.
A genus of very small TAPEWORMS, in the family Taeniidae. The adult form is found in various CARNIVORA but not humans. The larval form is seen in humans under certain epidemiologic circumstances.
Infection of humans or animals with hookworms other than those caused by the genus Ancylostoma or Necator, for which the specific terms ANCYLOSTOMIASIS and NECATORIASIS are available.
An infection caused by the infestation of the larval form of tapeworms of the genus Echinococcus. The liver, lungs, and kidney are the most common areas of infestation.
Infection with nematodes of the genus TRICHURIS, formerly called Trichocephalus.
Infection by nematodes of the genus ASCARIS. Ingestion of infective eggs causes diarrhea and pneumonitis. Its distribution is more prevalent in areas of poor sanitation and where human feces are used for fertilizer.
Liver disease caused by infections with parasitic tapeworms of the genus ECHINOCOCCUS, such as Echinococcus granulosus or Echinococcus multilocularis. Ingested Echinococcus ova burrow into the intestinal mucosa. The larval migration to the liver via the PORTAL VEIN leads to watery vesicles (HYDATID CYST).
A genus of nematode worms comprising the whipworms.
A species of parasitic nematode that is the largest found in the human intestine. Its distribution is worldwide, but it is more prevalent in areas of poor sanitation. Human infection with A. lumbricoides is acquired by swallowing fully embryonated eggs from contaminated soil.
Infections by nematodes, general or unspecified.
Determination of parasite eggs in feces.
Infection with nematodes of the genus ENTEROBIUS; E. vermicularis, the pinworm of man, causes a crawling sensation and pruritus. This condition results in scratching the area, occasionally causing scarification.
Compounds with a BENZENE fused to IMIDAZOLES.
Infestation with parasitic worms of the helminth class.
A species of parasitic nematodes distributed throughout the Pacific islands that infests the lungs of domestic rats. Human infection, caused by consumption of raw slugs and land snails, results in eosinophilic meningitis.
Infections of the INTESTINES with PARASITES, commonly involving PARASITIC WORMS. Infections with roundworms (NEMATODE INFECTIONS) and tapeworms (CESTODE INFECTIONS) are also known as HELMINTHIASIS.
Antinematodal benzimidazole used in veterinary medicine.
Helminth infection of the lung caused by Echinococcus granulosus or Echinococcus multilocularis.
An anthelmintic used in most schistosome and many cestode infestations.
Broad spectrum antinematodal anthelmintic used also in veterinary medicine.
An antihelminthic drug that has been tried experimentally in rheumatic disorders where it apparently restores the immune response by increasing macrophage chemotaxis and T-lymphocyte function. Paradoxically, this immune enhancement appears to be beneficial in rheumatoid arthritis where dermatitis, leukopenia, and thrombocytopenia, and nausea and vomiting have been reported as side effects. (From Smith and Reynard, Textbook of Pharmacology, 1991, p435-6)
Agents used to treat tapeworm infestations in man or animals.
A depolarizing neuromuscular-blocking agent, that causes persistent nicotinic activation resulting in spastic paralysis of susceptible nematodes. It is a drug of second-choice after benzimidazoles for treatment of ascariasis, hookworm, and pinworm infections, being effective after a single dose. (From Smith and Reynard, Textbook of Pharmacology, 1992, p920)
Infection with tapeworms of the genus Hymenolepis.
A superfamily of nematode parasitic hookworms consisting of four genera: ANCYLOSTOMA; NECATOR; Bunostomum; and Uncinaria. ANCYLOSTOMA and NECATOR occur in humans and other mammals. Bunostomum is common in ruminants and Uncinaria in wolves, foxes, and dogs.
The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.
Freedom from exposure to danger and protection from the occurrence or risk of injury or loss. It suggests optimal precautions in the workplace, on the street, in the home, etc., and includes personal safety as well as the safety of property.
Unforeseen occurrences, especially injuries in the course of work-related activities.
Services offered to the library user. They include reference and circulation.
2-Hydroxy-N-phenylbenzamides. N-phenyl substituted salicylamides. Derivatives have been used as fungicides, anti-mildew agents and topical antifungal agents. In concentrated form may cause irritation of skin and mucous membranes.
Common name for Carassius auratus, a type of carp (CARPS).
Instruments used to observe distant objects.
Narcotic analgesic related to CODEINE, but more potent and more addicting by weight. It is used also as cough suppressant.
A semisynthetic derivative of CODEINE.
An opioid analgesic with actions and uses similar to those of MORPHINE, apart from an absence of cough suppressant activity. It is used in the treatment of moderate to severe pain, including pain in obstetrics. It may also be used as an adjunct to anesthesia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1092)
Organized efforts to insure obedience to the laws of a community.
The inability in the male to have a PENILE ERECTION due to psychological or organ dysfunction.
A family of New World monkeys in the infraorder PLATYRRHINI consisting of two subfamilies: Callicebinae and Pitheciinae.
A series of heterocyclic compounds that are variously substituted in nature and are known also as purine bases. They include ADENINE and GUANINE, constituents of nucleic acids, as well as many alkaloids such as CAFFEINE and THEOPHYLLINE. Uric acid is the metabolic end product of purine metabolism.
A group of pyrido-indole compounds. Included are any points of fusion of pyridine with the five-membered ring of indole and any derivatives of these compounds. These are similar to CARBAZOLES which are benzo-indoles.
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
A malignant neoplasm that may be classified either as a glioma or as a primitive neuroectodermal tumor of childhood (see NEUROECTODERMAL TUMOR, PRIMITIVE). The tumor occurs most frequently in the first decade of life with the most typical location being the cerebellar vermis. Histologic features include a high degree of cellularity, frequent mitotic figures, and a tendency for the cells to organize into sheets or form rosettes. Medulloblastoma have a high propensity to spread throughout the craniospinal intradural axis. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2060-1)
Glioma derived from EPENDYMOGLIAL CELLS that tend to present as malignant intracranial tumors in children and as benign intraspinal neoplasms in adults. It may arise from any level of the ventricular system or central canal of the spinal cord. Intracranial ependymomas most frequently originate in the FOURTH VENTRICLE and histologically are densely cellular tumors which may contain ependymal tubules and perivascular pseudorosettes. Spinal ependymomas are usually benign papillary or myxopapillary tumors. (From DeVita et al., Principles and Practice of Oncology, 5th ed, p2018; Escourolle et al., Manual of Basic Neuropathology, 2nd ed, pp28-9)
Pharmacy services accessed via electronic means.
Drugs manufactured and sold with the intent to misrepresent its origin, authenticity, chemical composition, and or efficacy. Counterfeit drugs may contain inappropriate quantities of ingredients not listed on the label or package. In order to further deceive the consumer, the packaging, container, or labeling, may be inaccurate, incorrect, or fake.
Facilities for the preparation and dispensing of drugs.
Laws and regulations, pertaining to the field of pharmacy, proposed for enactment or enacted by a legislative body.
Drugs that cannot be sold legally without a prescription.
Control of drug and narcotic use by international agreement, or by institutional systems for handling prescribed drugs. This includes regulations concerned with the manufacturing, dispensing, approval (DRUG APPROVAL), and marketing of drugs.

Effect of mebendazole and praziquantel on glucosephosphate isomerase and glyceraldehydephosphate dehydrogenase in Echinococcus granulosus cyst wall harbored in mice. (1/136)

AIM: To study effects of antihydatid drugs on glucosephosphate isomerase (GPI) and glyceraldehydephosphate dehydrogenase (GAPDH) in Echinococcus granulosus cyst wall. METHODS: Mice infected with the parasite for 8-10 months were treated i.g. with mebendazole (Meb) or praziquantel (Pra). The activities of GPI and GAPDH in the cysts were measured by the formation of NADH or NADPH. RESULTS: GPI activity in the cyst wall was 197 +/- 103 U, while that of GAPDH was 25 +/- 13 U. When infected mice were treated i.g. with Meb 25-50 mg.kg-1.d-1 for 7-14 d, no apparent effect on the GAPDH activity in the cyst was found. In mice treated i.g. with praziquantel (Pra) 500 mg.kg-1.d-1 for 14 d, the GAPDH activity in the cyst wall was inhibited by 26.5%. As to GPI activity only the group treated i.g. with Meb 25 mg.kg-1.d-1 for 14 d showed 33.2% inhibition of the enzyme in the collapsed cyst wall. CONCLUSION: GPI and GAPDH are not the major targets attacked by the antihydatid drug.  (+info)

A controlled evaluation of two school-based anthelminthic chemotherapy regimens on intensity of intestinal helminth infections. (2/136)

BACKGROUND: School-based deworming programmes have been promoted as a cost-effective strategy for control of nematode infection in developing countries. While numerous efficacy studies have been conducted, there is little information on actual programme effectiveness in areas of intense transmission. METHODS: A randomized trial of a school-based deworming programme was conducted in 12 primary schools on Pemba Island, Zanzibar. Four schools each were randomized to control, twice a year deworming with single dose mebendazole or three times a year deworming. Baseline and 12-month follow-up data on helminth infection using the Kato-Katz technique, demographic information and nutritional status were collected on 3028 children from March 1994 to May 1995. RESULTS: Intensity of infection measured as eggs per gram of faeces (epg) declined significantly for Ascaris lumbricoides, Trichuris trichiura and hookworm infections in both treatment groups. A. lumbricoides infection intensity declined 63.1% and 96.7% in the twice and three times per year treatment groups compared to the controls. T. trichiura infection intensity declined 40.4% and 75.9% respectively and hookworm intensity declined 35.3% and 57.2% respectively compared to control schools. CONCLUSIONS: These results suggest that school-based programmes can be a cost-effective approach for controlling the intensity of intestinal helminth infection even in environments where transmission is high.  (+info)

Long-term evaluation of patients with hydatidosis treated with benzimidazole carbamates. (3/136)

Four hundred forty-eight patients with 929 Echinococcus granulosus hydatid cysts received 3- to 6-month continuous cycles of mebendazole or albendazole treatment and underwent prolonged follow-up by clinical visits and imaging studies (range, 1-14 years) to assess the long-term outcome of treatment. Degenerative changes and relapse were assessed by imaging techniques. At the end of therapy, 74.1% of the hydatid cysts showed degenerative changes. These were more frequent in albendazole-treated than in mebendazole-treated cysts (82.2% vs. 56.1%; P < .001). During long-term follow-up, 104 cysts (22%) had degenerative changes that progressed, whereas 163 cysts (approximately 25%) relapsed. The percentages of relapses in the two drug-treated groups were almost the same. Relapses occurred more frequently in type II cysts of the liver. Cysts recurred most often (78.5%; P < .001) within the first 2 years after treatment ended. Further chemotherapy cycles induced degenerative changes in >90% of relapsed cysts without inducing more frequent or more severe side effects than those observed during the initial cycles.  (+info)

Efficacy of various chemotherapeutic agents on the growth of Spironucleus vortens, an intestinal parasite of the freshwater angelfish. (4/136)

Seven chemotherapeutic agents (dimetridazole, metronidazole, pyrimethamine, albendazole, fenbendazole, mebendazole and magnesium sulfate) were examined for growth inhibition on the cultivation of Spironucleus vortens. Dimetridazole and metronidazole were effective in inhibiting the parasite's growth. At concentrations of 1 microgram ml-1 or higher, both dramatically decreased numbers of parasites. At 24 h exposure, 33% of parasites were inhibited when exposed to dimetridazole or metronidazole at concentrations of 2 and 4 micrograms ml-1, respectively. Dimetridazole at 4 micrograms ml-1 or higher concentrations decreased the number of organisms to 50% or less after 48 h exposure. During the same period of time, the numbers of parasites decreased to 50% or less when exposed to metronidazole at 6 micrograms ml-1 or higher. Pyrimethamine at concentrations of 1 to 10 micrograms ml-1 was not effective in inhibiting the parasite's growth. Albendazole and fenbendazole at concentrations of 0.1 and 0.5 microgram ml-1 were similar in inhibiting the growth of the organism. Both compounds suppressed parasite growth at concentrations of 1.0 microgram ml-1 or higher after 24 h exposure. Mebendazole inhibited the parasite's growth at concentrations of 0.5 microgram ml-1 or higher. At 72 h exposure, 45 to 50% of the parasites were inhibited when exposed to mebendazole at concentrations higher than 0.5 microgram ml-1. Magnesium sulfate at concentrations of 70 mg ml-1 or higher also suppressed the growth of parasites after 24 h exposure. These results indicate that dimetridazole, metronidazole and mebendazole are the most effective chemotherapeutic agents in vitro at inhibiting the growth of S. vortens.  (+info)

A case of presumed ocular toxocariasis in a 28-year old woman. (5/136)

This is a case of presumed ocular toxocariasis in a 28-year old woman complaining of a sudden onset of nasal side field defect of the right eye. The patient had been suffering from uveitis for ten months. Fundoscopic examination of the right eye showed a rhegmatogenous retinal detachment. Furthermore, a retinochoroidal granulomatous lesion was observed nearby the tear site. Scleral buckling, cryotherapy, and gas injection(SF6, pure gas, 0.7 cc) were conducted. Mebendazole was prescribed for one month at 25 mg/kg per body weight daily. Even though the interventions resulted in the recovery of the field defect, anti-Toxocara IgG and IgE titer levels did not decrease when checked three months after the treatment ended. This is the first confirmed serological ocular toxocariasis case in Korea. Uveitis may be a clinical presentation prior to retinal detachment of a person with toxocariasis.  (+info)

Pharmacokinetics of UMF-078, a candidate antifilarial drug, in infected dogs. (6/136)

The pharmacokinetics of the filaricidal benzimidazole compounds UMF-078 and UMF-289 were evaluated in beagle dogs experimentally infected with Brugia pahangi. Twenty-four infected microfilaremic beagles were selected and randomly allocated into 4 treatment groups of 6 dogs each: oral (PO) UMF-078, PO UMF-289 (the HCl salt form of UMF-078), intramuscular (IM) UMF-078, and untreated controls. Equivalent doses of 50 mg/kg of the free base were given twice a day for 3 days to the 3 groups of treated dogs. Oral absorption is rapid compared with IM dosing; the absorption half-life (K01-HL) for the IM treatment is approximately 14 hr compared with 1 and 2 hr for the PO regimen of salt and free base forms, respectively. The elimination half-lives (K10-HL) for the PO regimens are 13 and 15 hr for the salt and free base forms, respectively. Because of sustained absorption following IM dosing, the K10-HL is prolonged. In contrast to oral administration, IM dosing of UMF-078 provides sustained, relatively low plasma drug levels, with good tolerance and efficacy.  (+info)

Epidemiology and control of enterobiasis in a developmental center. (7/136)

OBJECTIVE: To determine if enterobiasis could be controlled in a developmental center. DESIGN: Population-based study. Annual screening of all residents by perianal swabs for enterobiasis and on admission or discharge. Treatment of infected residents and their contacts with mebendazole, 100 mg orally, with two doses given 14 days apart. MAIN OUTCOME MEASURES: The number of residents with enterobiasis and the cost of the program. RESULTS: The prevalence of enterobiasis fell rapidly and progressively, from 21% before mass medication to 1% after 3 years. CONCLUSION: Mass medication of residents with enterobiasis and their contacts was beneficial, harmless, and cost effective.  (+info)

Blinded, placebo-controlled trial of antiparasitic drugs for trichinosis myositis. (8/136)

There is no consensus on the benefits of treatment with any specific anthelminthic compound on muscle-stage trichinosis. A double-blind, placebo-controlled comparison was done of 3 antiparasitic drugs during an outbreak of trichinosis in Chiangrai Province, northern Thailand. Forty-six adults were randomized to receive 10 days of oral treatment with mebendazole (200 mg twice a day), thiabendazole (25 mg/kg twice a day), fluconazole (400 mg initially, then 200 mg daily), or placebo. All patients received treatment to eradicate adult intestinal worms. Trichinella spiralis infection was proved parasitologically in 19 (41%) of 46 patient and by serodiagnosis in all cases. Significantly more patients improved after treatment with mebendazole (12/12) and thiabendazole (7/7) than after treatment with placebo (6/12; P<.05) or fluconazole (6/12). Muscle tenderness resolved in more patients treated with thiabendazole and mebendazole than in those treated with placebo (P<.05). However, 30% of volunteers could not tolerate the side effects of thiabendazole. In summary, Trichinella myositis responds to thiabendazole and to mebendazole.  (+info)

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TY - JOUR. T1 - A comparative study of different albendazole and mebendazole regimens for the treatment of intestinal infections in school children of usigu division, Western Kenya. AU - Muchiri, E. M.. AU - Thiongo, F. W.. AU - Magnussen, P.. AU - Ouma, J. H.. PY - 2001/1/1. Y1 - 2001/1/1. N2 - A clinical trial to compare the effectiveness of 4- and 6-mo repeated treatment with albendazole 600 mg (Zentel®, SmithKline Beecham) or mebendazole 600 mg (Vermox®, Janssen) on geohelminth infections was carried out on children in 6 primary schools; the study included 1,186 children, ages 4 to 19 yr. Kato-Katz examination was performed on stool samples before and after treatment. Overall, albendazole produced better cure rates and egg reduction rates for geohelminths. The cure rates for albendazole were 92.4% for hookworm infection, 83.5% for Ascaris lumbricoides, and 67.8% for Trichuris trichiura. Mebendazole given either 2 or 3 times in a year had cure rates of 50 and 55.0% (respectively) for ...
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Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Eva Stupková Supervisor: RNDr. Věra Králová, Ph.D. Title of diploma thesis: Effect of mebendazole on proliferation, migration and adhesion of oral carcinoma cells in vitro Mebendazole is one of commonly used anthelmintics in both human and veterinary medicine. The mechanism of its action is based on microtubule synthesis inhibition. This thesis is focused on mebendazole effect on cancer cells. Especially, we studied the effect of mebendazole on proliferation, migration and adhesion of squamous-cell carcinoma (SCC) cells, very aggressive and highly invasive cancerous disease. Our experiments ran on two cancerous cell lines (DOK, PE/CA-PJ15) and on non-cancerous gingival fibroblasts. We used WST-1 method for proliferation change assessment and xCELLigence RTCA DP Analyzer for measuring the effect on migration and adhesion of SCC cells. In our experiments, mebendazole caused ...
Mebendazole is an anti-parasitic drug, for parasites and worms, which is one of the most under-utilized drugs in medicine. Mebendazole was not used frequently enough, in the U.S.; thus, manufacturers raised the price beyond reason. ($130-$150 per pill). Mebendazole was available at compounding pharmacies, at a lower price; however, manufacturers now discontinued the manufacture and sale of powdered mebendazole, leaving pills as the only option. (Mebendazole remains available in other countries, at more reasonable prices.) ...
... is available as a generic medication.[6] Mebendazole is distributed in international markets by Johnson and Johnson ... Carbamazepine and phenytoin lower serum levels of mebendazole. Cimetidine does not appreciably raise serum mebendazole (in ... "Mebendazole". International Drug Price Indicator Guide. Archived from the original on 5 March 2017. Retrieved 18 August 2015.. ... "Treatment of hydatid disease with high oral doses of mebendazole. Long-term follow-up of plasma mebendazole levels and drug ...
While mebendazole still retains some binding affinity to human and Drosophilia β-tubulin, albendazole almost exclusively binds ... "Mebendazole". Drugs.com. The American Society of Health-System Pharmacists. Archived from the original on December 11, 2019. ... The anti-worm drugs mebendazole and albendazole as well as the anti-gout agent colchicine bind to tubulin and inhibit ...
Mebendazole Eradication of infectious disease Neglected tropical diseases Plumb DC (2011). "Albendazole". Plumb's Veterinary ... Trichuriasis (whipworm infection), sometimes considered as an alternative to mebendazole and sometimes considered to be the ... Dayan AD (May 2003). "Albendazole, mebendazole and praziquantel. Review of non-clinical toxicity and pharmacokinetics". Acta ... as an alternative to mebendazole Mansonelliasis when caused by Mansonella perstans. Albendazole works against the adult worms ...
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She is then given mebendazole. Callie improves rapidly, but runs away while unsupervised. She leaves behind a note, saying that ...
Alternative agents include mebendazole and albendazole. Successful treatment with ivermectin has also been reported. Another ...
The patient gets two mebendazole pills. However, the patient's lungs fill with fluid and become severely compromised. Foreman ...
Treatment is by either thiabendazole or mebendazole. Trichinella infection can be prevented by cooking pork meat properly, or ...
Mebendazole, triclabendazole and fenbendazole are commonly used. Ivermectin and pyrantel pamoate are also effective. The ...
The drugs of choice for soil-transmitted helminths are mebendazole and albendazole;[3] for schistosomiasis and tapeworms it is ... "Assessment of Anthelmintic Efficacy of Mebendazole in School Children in Six Countries Where Soil-Transmitted Helminths Are ...
Another treatment that can be used is mebendazole. These medication have been shown to lessen the infection by this parasite ...
Mebendazole at 11 mg/kg, PO, has also been successful. Taking an infected animal to a vet is the best option for ridding a pet ...
In the UK, mebendazole and piperazine are currently (2007) preferred. Mebendazole has a much higher failure rate in clinical ...
Mebendazole and thiabendazole have also both been cited to work. Because the only way of developing acanthocephaliasis is ...
... of children can be carried out by administering mebendazole and albendazole which are two types of anthelmintic ... It involves giving all children doses of Albendazole or Mebendazole. However, in 2013 the Director of the National Institute of ... October 2014). "Assessment of anthelmintic efficacy of mebendazole in school children in six countries where soil-transmitted ... Deworming programmes for children usually administer an anthelmintic drug such as albendazole or mebendazole (or praziquantel ...
Mebendazole can be given with a single dose twice a day for three consecutive days. Albendazole is given at a single dose. WHO ... For this purpose, broad-spectrum benzimidazoles such as mebendazole and albendazole are the drugs of choice recommended by WHO ... The World Health Organizations recommended albendazole or mebendazole for treatment. One strategy to control the disease in ... However, it has been reported that albendazole, mebendazole, and pyrantel pamoate are not entirely effective against T. ...
V tomto článku byl použit překlad textu z článku Mebendazole na anglické Wikipedii. ... Mebendazole Monograph for Professionals - Drugs.com. web.archive.org [online]. 2015-09-07 [cit. 2019-02-09]. Dostupné v archivu ... Repositioning of the anthelmintic drug mebendazole for the treatment for colon cancer. Journal of Cancer Research and Clinical ... Mebendazole inhibits growth of human adrenocortical carcinoma cell lines implanted in nude mice. Cancer Chemotherapy and ...
For this purpose, broad-spectrum benzimidazoles such as mebendazole and albendazole are the drugs of choice recommended by WHO ... Single‐dose of albendazole, mebendazole, and ivermectin are effective against ascariasis. They are effective at removing ... Treatments recommended by the World Health Organization are the medications albendazole, mebendazole, levamisole, or pyrantel ... Those recommended by the World Health Organization for ascariasis are: albendazole, mebendazole, levamisole and pyrantel ...
Benzimidazoles such as mebendazole, parbendazole and thiabendazole are also highly effective. A draft assembly of the genome of ...
Naturally infected hens were dewormed completely in 24 hours using mebendazole orally at doses 25 mg/kg body weight and higher ... Matta SC (1980). "Efficacy of mebendazole (Pantelmin-Ethnor) against some common cestodes of poultry". Indian Journal of ...
... and mebendazole, but lower activity than the combined regimen of mebendazole and DEC. However, more research may be needed into ... Mebendazole and thiabendazole have a greater effect than previously described drugs, but are not sufficient for treatment alone ... Mebendazole, another possible treatment for M. perstans filariasis, has been shown to be effective in significantly reducing ... Combination treatments with DEC and mebendazole have had the most success. In the most recent clinical trials, doxycycline has ...
Children can be treated by administering, for example, mebendazole and albendazole. The cost is relatively low. According to ...
This factory would soon produce the active compound of some Janssen products, such as mebendazole. In 1985, now operating as ... Active substance: mebendazole) Risperdal (antipsychotic, against mental illness such as schizophrenia. Active substance: ... mebendazole) Nizoral (ketoconazole) (Removed in 2005) Risperdal (risperidone) Sirturo (bedaquiline) - an diarylquinoline anti- ...
A single 100 milligram dose of mebendazole with one repetition after a week, is considered the safest, and is usually effective ... Treatment is typically with two doses of the medications mebendazole, pyrantel pamoate, or albendazole two weeks apart. ... The benzimidazole compounds albendazole (brand names e.g., Albenza, Eskazole, Zentel and Andazol) and mebendazole (brand names ... with cure rate of 96%. Mebendazole has no serious side effects, although abdominal pain and diarrhea have been reported. ...
Chotmongkol V (2006). "Treatment of eosinophilic meningitis with a combination of prednisolone and mebendazole". Am J Trop Med ...
Visceral toxocariasis in humans can be treated with antiparasitic drugs such as albendazole or mebendazole, tiabendazole or ... Either albendazole (preferred) or mebendazole ("second line therapy") may be prescribed. Granulomas can be surgically removed, ...
C. philippinensis infections should be treated with 200 mg of mebendazole. This drug is taken twice a day for 20 days or until ...
Treatment is typically with the medications albendazole or mebendazole for one to three days. Iron supplements may be needed in ... found that when comparing a group of pregnant women treated with mebendazole with a control placebo group, both illustrated ... This substantiates prior claims that albendazole is much more effective than mebendazole for hookworm infections. Also of note ... The most common treatment for hookworm are benzimidazoles, specifically albendazole and mebendazole. BZAs kill adult worms by ...
In humans, treatment is by anthelminthic medications, such as albendazole and mebendazole. Treatment in animals can be done ...
Treatment is with three days of the medication: albendazole, mebendazole or ivermectin. People often become infected again ...

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  • Secondary Objectives of the study include to determine the safety, tolerability and toxicity of mebendazole in this patient population, determine the plasma levels of mebendazole in this patient population and Determine progression-free and overall survival of mebendazole in an extended cohort of patients with treatment refractory pediatric brain cancer. (clinicaltrials.gov)
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  • To investigate this, we examined the effects of mebendazole on GL261 glioblastoma cell viability, microtubule polymerization and metaphase arrest, and found that the effective concentrations to inhibit these functions are very similar. (molmed.org)
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  • Taken together, these results indicate that the cell toxicity of mebendazole is indeed caused by inhibiting microtubule formation. (molmed.org)
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  • Other drugs are used to treat worm infections outside the digestive tract, as mebendazole is poorly absorbed into the bloodstream. (wikipedia.org)
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  • Mebendazole is also sometimes used to treat infections caused by tapeworms. (medlineplus.gov)
  • Poor absorption in digestive tract makes mebendazole an efficient drug for treating intestinal parasitic infections with limited adverse effects. (wikipedia.org)
  • Preventive chemotherapy with albendazole or mebendazole is the current strategy to control soil-transmitted helminth (STH) infections (i.e. (biomedcentral.com)
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  • The manufacturer's leaflet will give you more information about mebendazole and a full list of the side-effects which you may experience from taking it. (patient.info)
  • No side‐effects were observed in the mebendazole‐treated group, whereas nausea, anorexia and metallic taste were observed in 4.9, 6 and 24 per cent of metronidazole‐treated children, respectively. (oup.com)
  • In conclusion, the use of mebendazole, which is less toxic with no side‐effects, is available and effective on Giardia intestinalis as well as intestinal nematodes, is recommended especially in the areas where giardiasis and intestinal nematodiasis are prevalent and overlap. (oup.com)
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  • Our study describes the therapeutic utility and mechanism of action of mebendazole, one of the compounds identified from this screen as an antimelanoma agent. (aacrjournals.org)
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  • The primary objectives of this study are to determine the maximum tolerated dose (MTD) of oral mebendazole in patients with recurrent/progressive pediatric brain tumors and to confirm the tolerance of the MTD of oral mebendazole by assessing tolerance in a dose expansion cohort. (clinicaltrials.gov)
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  • Mebendazole has been shown to be useful in treating gastro-intestinal worms in both dogs and humans, however, it is not effective against most worm larvae, according to medical-dictionary.thefreedictionary.com. (cuteness.com)
  • DeWorm (Mebendazole) is a type of antihelmintic (anti-worm) drug, which prevents the growth and multiplication of worms in the body. (4nrx.org)
  • Mebendazole is thought to work by selectively inhibiting the synthesis of microtubules in parasitic worms, and by destroying extant cytoplasmic microtubules in their intestinal cells, thereby blocking the uptake of glucose and other nutrients, resulting in the gradual immobilization and eventual death of the helminths. (wikipedia.org)
  • Although mebendazole kills the adult worms it doesn't kill their eggs, so it's really important to be very thorough with hygiene, even after you've taken the treatment. (netdoctor.co.uk)
  • Mebendazole is thought to cause slow immobilization and death of the worms by selectively inhibiting the synthesis of microtubules. (thefullwiki.org)
  • Mebendazole ( C 16 H 13 N 3 O 3 ) causes slow immobilization and death of the worms by selectively and irreversibly blocking uptake of glucose and other nutrients in susceptible adult intestine where helminths dwell. (chemeurope.com)
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  • While mebendazole still retains some binding affinity to human and Drosophilia β-tubulin, albendazole almost exclusively binds to the β-tubulin of worms and other lower eukaryotes. (wikipedia.org)
  • The inhibition by metronidazole of survival of unilocular hydatid protoscoleces was similar to that of mebendazole. (eurekamag.com)
  • Your family members or other people in your household may also need to be treated with mebendazole or other medicines. (wellspan.org)
  • However mebendazole has impact on mammalian cells mostly by inhibiting polymeration of tubulin dimers, thereby disrupting essential microtubule structures such as mitotic spindle. (wikipedia.org)
  • We further show that mebendazole-resistant melanocytes can be sensitized through reduction of Bcl-2 protein levels, showing the essential role of Bcl-2 in the cellular response to mebendazole-mediated tubulin disruption. (aacrjournals.org)
  • Furthermore, mebendazole has been shown to induce depolymerization of tubulin in a variety of cancer models ( 6 , 7 ). (aacrjournals.org)
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  • To avoid this, heavily infested patients may be treated with piperazine, either before or instead of mebendazole. (wikipedia.org)
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