A benzimidazole that acts by interfering with CARBOHYDRATE METABOLISM and inhibiting polymerization of MICROTUBULES.
Substances used in the treatment or control of nematode infestations. They are used also in veterinary practice.
A benzimidazole broad-spectrum anthelmintic structurally related to MEBENDAZOLE that is effective against many diseases. (From Martindale, The Extra Pharmacopoeia, 30th ed, p38)
Agents destructive to parasitic worms. They are used therapeutically in the treatment of HELMINTHIASIS in man and animal.
A genus of very small TAPEWORMS, in the family Taeniidae. The adult form is found in various CARNIVORA but not humans. The larval form is seen in humans under certain epidemiologic circumstances.
Infection of humans or animals with hookworms other than those caused by the genus Ancylostoma or Necator, for which the specific terms ANCYLOSTOMIASIS and NECATORIASIS are available.
An infection caused by the infestation of the larval form of tapeworms of the genus Echinococcus. The liver, lungs, and kidney are the most common areas of infestation.
Infection with nematodes of the genus TRICHURIS, formerly called Trichocephalus.
Infection by nematodes of the genus ASCARIS. Ingestion of infective eggs causes diarrhea and pneumonitis. Its distribution is more prevalent in areas of poor sanitation and where human feces are used for fertilizer.
Liver disease caused by infections with parasitic tapeworms of the genus ECHINOCOCCUS, such as Echinococcus granulosus or Echinococcus multilocularis. Ingested Echinococcus ova burrow into the intestinal mucosa. The larval migration to the liver via the PORTAL VEIN leads to watery vesicles (HYDATID CYST).
A genus of nematode worms comprising the whipworms.
A species of parasitic nematode that is the largest found in the human intestine. Its distribution is worldwide, but it is more prevalent in areas of poor sanitation. Human infection with A. lumbricoides is acquired by swallowing fully embryonated eggs from contaminated soil.
Infections by nematodes, general or unspecified.
Determination of parasite eggs in feces.
Infection with nematodes of the genus ENTEROBIUS; E. vermicularis, the pinworm of man, causes a crawling sensation and pruritus. This condition results in scratching the area, occasionally causing scarification.
Compounds with a BENZENE fused to IMIDAZOLES.
Infestation with parasitic worms of the helminth class.
A species of parasitic nematodes distributed throughout the Pacific islands that infests the lungs of domestic rats. Human infection, caused by consumption of raw slugs and land snails, results in eosinophilic meningitis.
Infections of the INTESTINES with PARASITES, commonly involving PARASITIC WORMS. Infections with roundworms (NEMATODE INFECTIONS) and tapeworms (CESTODE INFECTIONS) are also known as HELMINTHIASIS.
Antinematodal benzimidazole used in veterinary medicine.
Helminth infection of the lung caused by Echinococcus granulosus or Echinococcus multilocularis.
An anthelmintic used in most schistosome and many cestode infestations.
Broad spectrum antinematodal anthelmintic used also in veterinary medicine.
An antihelminthic drug that has been tried experimentally in rheumatic disorders where it apparently restores the immune response by increasing macrophage chemotaxis and T-lymphocyte function. Paradoxically, this immune enhancement appears to be beneficial in rheumatoid arthritis where dermatitis, leukopenia, and thrombocytopenia, and nausea and vomiting have been reported as side effects. (From Smith and Reynard, Textbook of Pharmacology, 1991, p435-6)
Agents used to treat tapeworm infestations in man or animals.
A depolarizing neuromuscular-blocking agent, that causes persistent nicotinic activation resulting in spastic paralysis of susceptible nematodes. It is a drug of second-choice after benzimidazoles for treatment of ascariasis, hookworm, and pinworm infections, being effective after a single dose. (From Smith and Reynard, Textbook of Pharmacology, 1992, p920)
Infection with tapeworms of the genus Hymenolepis.
A superfamily of nematode parasitic hookworms consisting of four genera: ANCYLOSTOMA; NECATOR; Bunostomum; and Uncinaria. ANCYLOSTOMA and NECATOR occur in humans and other mammals. Bunostomum is common in ruminants and Uncinaria in wolves, foxes, and dogs.
The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.
Freedom from exposure to danger and protection from the occurrence or risk of injury or loss. It suggests optimal precautions in the workplace, on the street, in the home, etc., and includes personal safety as well as the safety of property.
Unforeseen occurrences, especially injuries in the course of work-related activities.
Services offered to the library user. They include reference and circulation.
2-Hydroxy-N-phenylbenzamides. N-phenyl substituted salicylamides. Derivatives have been used as fungicides, anti-mildew agents and topical antifungal agents. In concentrated form may cause irritation of skin and mucous membranes.
Common name for Carassius auratus, a type of carp (CARPS).
Instruments used to observe distant objects.
The inability in the male to have a PENILE ERECTION due to psychological or organ dysfunction.
A family of New World monkeys in the infraorder PLATYRRHINI consisting of two subfamilies: Callicebinae and Pitheciinae.
A series of heterocyclic compounds that are variously substituted in nature and are known also as purine bases. They include ADENINE and GUANINE, constituents of nucleic acids, as well as many alkaloids such as CAFFEINE and THEOPHYLLINE. Uric acid is the metabolic end product of purine metabolism.
A group of pyrido-indole compounds. Included are any points of fusion of pyridine with the five-membered ring of indole and any derivatives of these compounds. These are similar to CARBAZOLES which are benzo-indoles.
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
A malignant neoplasm that may be classified either as a glioma or as a primitive neuroectodermal tumor of childhood (see NEUROECTODERMAL TUMOR, PRIMITIVE). The tumor occurs most frequently in the first decade of life with the most typical location being the cerebellar vermis. Histologic features include a high degree of cellularity, frequent mitotic figures, and a tendency for the cells to organize into sheets or form rosettes. Medulloblastoma have a high propensity to spread throughout the craniospinal intradural axis. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2060-1)
Glioma derived from EPENDYMOGLIAL CELLS that tend to present as malignant intracranial tumors in children and as benign intraspinal neoplasms in adults. It may arise from any level of the ventricular system or central canal of the spinal cord. Intracranial ependymomas most frequently originate in the FOURTH VENTRICLE and histologically are densely cellular tumors which may contain ependymal tubules and perivascular pseudorosettes. Spinal ependymomas are usually benign papillary or myxopapillary tumors. (From DeVita et al., Principles and Practice of Oncology, 5th ed, p2018; Escourolle et al., Manual of Basic Neuropathology, 2nd ed, pp28-9)
Pharmacy services accessed via electronic means.
Drugs manufactured and sold with the intent to misrepresent its origin, authenticity, chemical composition, and or efficacy. Counterfeit drugs may contain inappropriate quantities of ingredients not listed on the label or package. In order to further deceive the consumer, the packaging, container, or labeling, may be inaccurate, incorrect, or fake.
Facilities for the preparation and dispensing of drugs.
Laws and regulations, pertaining to the field of pharmacy, proposed for enactment or enacted by a legislative body.
Drugs that cannot be sold legally without a prescription.
Control of drug and narcotic use by international agreement, or by institutional systems for handling prescribed drugs. This includes regulations concerned with the manufacturing, dispensing, approval (DRUG APPROVAL), and marketing of drugs.

Effect of mebendazole and praziquantel on glucosephosphate isomerase and glyceraldehydephosphate dehydrogenase in Echinococcus granulosus cyst wall harbored in mice. (1/136)

AIM: To study effects of antihydatid drugs on glucosephosphate isomerase (GPI) and glyceraldehydephosphate dehydrogenase (GAPDH) in Echinococcus granulosus cyst wall. METHODS: Mice infected with the parasite for 8-10 months were treated i.g. with mebendazole (Meb) or praziquantel (Pra). The activities of GPI and GAPDH in the cysts were measured by the formation of NADH or NADPH. RESULTS: GPI activity in the cyst wall was 197 +/- 103 U, while that of GAPDH was 25 +/- 13 U. When infected mice were treated i.g. with Meb 25-50 mg.kg-1.d-1 for 7-14 d, no apparent effect on the GAPDH activity in the cyst was found. In mice treated i.g. with praziquantel (Pra) 500 mg.kg-1.d-1 for 14 d, the GAPDH activity in the cyst wall was inhibited by 26.5%. As to GPI activity only the group treated i.g. with Meb 25 mg.kg-1.d-1 for 14 d showed 33.2% inhibition of the enzyme in the collapsed cyst wall. CONCLUSION: GPI and GAPDH are not the major targets attacked by the antihydatid drug.  (+info)

A controlled evaluation of two school-based anthelminthic chemotherapy regimens on intensity of intestinal helminth infections. (2/136)

BACKGROUND: School-based deworming programmes have been promoted as a cost-effective strategy for control of nematode infection in developing countries. While numerous efficacy studies have been conducted, there is little information on actual programme effectiveness in areas of intense transmission. METHODS: A randomized trial of a school-based deworming programme was conducted in 12 primary schools on Pemba Island, Zanzibar. Four schools each were randomized to control, twice a year deworming with single dose mebendazole or three times a year deworming. Baseline and 12-month follow-up data on helminth infection using the Kato-Katz technique, demographic information and nutritional status were collected on 3028 children from March 1994 to May 1995. RESULTS: Intensity of infection measured as eggs per gram of faeces (epg) declined significantly for Ascaris lumbricoides, Trichuris trichiura and hookworm infections in both treatment groups. A. lumbricoides infection intensity declined 63.1% and 96.7% in the twice and three times per year treatment groups compared to the controls. T. trichiura infection intensity declined 40.4% and 75.9% respectively and hookworm intensity declined 35.3% and 57.2% respectively compared to control schools. CONCLUSIONS: These results suggest that school-based programmes can be a cost-effective approach for controlling the intensity of intestinal helminth infection even in environments where transmission is high.  (+info)

Long-term evaluation of patients with hydatidosis treated with benzimidazole carbamates. (3/136)

Four hundred forty-eight patients with 929 Echinococcus granulosus hydatid cysts received 3- to 6-month continuous cycles of mebendazole or albendazole treatment and underwent prolonged follow-up by clinical visits and imaging studies (range, 1-14 years) to assess the long-term outcome of treatment. Degenerative changes and relapse were assessed by imaging techniques. At the end of therapy, 74.1% of the hydatid cysts showed degenerative changes. These were more frequent in albendazole-treated than in mebendazole-treated cysts (82.2% vs. 56.1%; P < .001). During long-term follow-up, 104 cysts (22%) had degenerative changes that progressed, whereas 163 cysts (approximately 25%) relapsed. The percentages of relapses in the two drug-treated groups were almost the same. Relapses occurred more frequently in type II cysts of the liver. Cysts recurred most often (78.5%; P < .001) within the first 2 years after treatment ended. Further chemotherapy cycles induced degenerative changes in >90% of relapsed cysts without inducing more frequent or more severe side effects than those observed during the initial cycles.  (+info)

Efficacy of various chemotherapeutic agents on the growth of Spironucleus vortens, an intestinal parasite of the freshwater angelfish. (4/136)

Seven chemotherapeutic agents (dimetridazole, metronidazole, pyrimethamine, albendazole, fenbendazole, mebendazole and magnesium sulfate) were examined for growth inhibition on the cultivation of Spironucleus vortens. Dimetridazole and metronidazole were effective in inhibiting the parasite's growth. At concentrations of 1 microgram ml-1 or higher, both dramatically decreased numbers of parasites. At 24 h exposure, 33% of parasites were inhibited when exposed to dimetridazole or metronidazole at concentrations of 2 and 4 micrograms ml-1, respectively. Dimetridazole at 4 micrograms ml-1 or higher concentrations decreased the number of organisms to 50% or less after 48 h exposure. During the same period of time, the numbers of parasites decreased to 50% or less when exposed to metronidazole at 6 micrograms ml-1 or higher. Pyrimethamine at concentrations of 1 to 10 micrograms ml-1 was not effective in inhibiting the parasite's growth. Albendazole and fenbendazole at concentrations of 0.1 and 0.5 microgram ml-1 were similar in inhibiting the growth of the organism. Both compounds suppressed parasite growth at concentrations of 1.0 microgram ml-1 or higher after 24 h exposure. Mebendazole inhibited the parasite's growth at concentrations of 0.5 microgram ml-1 or higher. At 72 h exposure, 45 to 50% of the parasites were inhibited when exposed to mebendazole at concentrations higher than 0.5 microgram ml-1. Magnesium sulfate at concentrations of 70 mg ml-1 or higher also suppressed the growth of parasites after 24 h exposure. These results indicate that dimetridazole, metronidazole and mebendazole are the most effective chemotherapeutic agents in vitro at inhibiting the growth of S. vortens.  (+info)

A case of presumed ocular toxocariasis in a 28-year old woman. (5/136)

This is a case of presumed ocular toxocariasis in a 28-year old woman complaining of a sudden onset of nasal side field defect of the right eye. The patient had been suffering from uveitis for ten months. Fundoscopic examination of the right eye showed a rhegmatogenous retinal detachment. Furthermore, a retinochoroidal granulomatous lesion was observed nearby the tear site. Scleral buckling, cryotherapy, and gas injection(SF6, pure gas, 0.7 cc) were conducted. Mebendazole was prescribed for one month at 25 mg/kg per body weight daily. Even though the interventions resulted in the recovery of the field defect, anti-Toxocara IgG and IgE titer levels did not decrease when checked three months after the treatment ended. This is the first confirmed serological ocular toxocariasis case in Korea. Uveitis may be a clinical presentation prior to retinal detachment of a person with toxocariasis.  (+info)

Pharmacokinetics of UMF-078, a candidate antifilarial drug, in infected dogs. (6/136)

The pharmacokinetics of the filaricidal benzimidazole compounds UMF-078 and UMF-289 were evaluated in beagle dogs experimentally infected with Brugia pahangi. Twenty-four infected microfilaremic beagles were selected and randomly allocated into 4 treatment groups of 6 dogs each: oral (PO) UMF-078, PO UMF-289 (the HCl salt form of UMF-078), intramuscular (IM) UMF-078, and untreated controls. Equivalent doses of 50 mg/kg of the free base were given twice a day for 3 days to the 3 groups of treated dogs. Oral absorption is rapid compared with IM dosing; the absorption half-life (K01-HL) for the IM treatment is approximately 14 hr compared with 1 and 2 hr for the PO regimen of salt and free base forms, respectively. The elimination half-lives (K10-HL) for the PO regimens are 13 and 15 hr for the salt and free base forms, respectively. Because of sustained absorption following IM dosing, the K10-HL is prolonged. In contrast to oral administration, IM dosing of UMF-078 provides sustained, relatively low plasma drug levels, with good tolerance and efficacy.  (+info)

Epidemiology and control of enterobiasis in a developmental center. (7/136)

OBJECTIVE: To determine if enterobiasis could be controlled in a developmental center. DESIGN: Population-based study. Annual screening of all residents by perianal swabs for enterobiasis and on admission or discharge. Treatment of infected residents and their contacts with mebendazole, 100 mg orally, with two doses given 14 days apart. MAIN OUTCOME MEASURES: The number of residents with enterobiasis and the cost of the program. RESULTS: The prevalence of enterobiasis fell rapidly and progressively, from 21% before mass medication to 1% after 3 years. CONCLUSION: Mass medication of residents with enterobiasis and their contacts was beneficial, harmless, and cost effective.  (+info)

Blinded, placebo-controlled trial of antiparasitic drugs for trichinosis myositis. (8/136)

There is no consensus on the benefits of treatment with any specific anthelminthic compound on muscle-stage trichinosis. A double-blind, placebo-controlled comparison was done of 3 antiparasitic drugs during an outbreak of trichinosis in Chiangrai Province, northern Thailand. Forty-six adults were randomized to receive 10 days of oral treatment with mebendazole (200 mg twice a day), thiabendazole (25 mg/kg twice a day), fluconazole (400 mg initially, then 200 mg daily), or placebo. All patients received treatment to eradicate adult intestinal worms. Trichinella spiralis infection was proved parasitologically in 19 (41%) of 46 patient and by serodiagnosis in all cases. Significantly more patients improved after treatment with mebendazole (12/12) and thiabendazole (7/7) than after treatment with placebo (6/12; P<.05) or fluconazole (6/12). Muscle tenderness resolved in more patients treated with thiabendazole and mebendazole than in those treated with placebo (P<.05). However, 30% of volunteers could not tolerate the side effects of thiabendazole. In summary, Trichinella myositis responds to thiabendazole and to mebendazole.  (+info)

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A Closantel/Mebendazole combination (Supaverm) was tested in eight discrete systems on several species of fish, with Goldfish and Koi in the majority. Within five to seven days from the first applications of Closantel/Mebendazole combination, and replicated in eight different systems, every member of every species of goldfish was 100% annihilated including Ranchus, Pembrookes, Midnights, Wakins, Telescopes, Shubunkins and Comets. Salt appears to enhance the killing effect of Closantel/Mebendazole combination on flukes. Carbon does not remove sufficient compound to save the Goldfish in treated systems. There appears to be no negative effect of Closantel/Mebendazole combination on Koi. Closantel/Mebendazole combination was 100% effective in the eradication of flukes in all systems in less than 36 hours without negative effect on plants, Koi or filter ...
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Bästa apotek för att köpa Vermox Grekland. Generisk Vermox (Mebendazole) används för att behandla vissa typer av maskinfektioner (t.ex. springmask, rundmask, piskmask, hakmask). Mebendazole är ett anthelmintiskt medel. Det fungerar genom att döda känsliga maskar och orsaka dem att stötas bort från kroppen. ...
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Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Eva Stupková Supervisor: RNDr. Věra Králová, Ph.D. Title of diploma thesis: Effect of mebendazole on proliferation, migration and adhesion of oral carcinoma cells in vitro Mebendazole is one of commonly used anthelmintics in both human and veterinary medicine. The mechanism of its action is based on microtubule synthesis inhibition. This thesis is focused on mebendazole effect on cancer cells. Especially, we studied the effect of mebendazole on proliferation, migration and adhesion of squamous-cell carcinoma (SCC) cells, very aggressive and highly invasive cancerous disease. Our experiments ran on two cancerous cell lines (DOK, PE/CA-PJ15) and on non-cancerous gingival fibroblasts. We used WST-1 method for proliferation change assessment and xCELLigence RTCA DP Analyzer for measuring the effect on migration and adhesion of SCC cells. In our experiments, mebendazole caused ...
Mebendazole is an anti-parasitic drug, for parasites and worms, which is one of the most under-utilized drugs in medicine. Mebendazole was not used frequently enough, in the U.S.; thus, manufacturers raised the price beyond reason. ($130-$150 per pill). Mebendazole was available at compounding pharmacies, at a lower price; however, manufacturers now discontinued the manufacture and sale of powdered mebendazole, leaving pills as the only option. (Mebendazole remains available in other countries, at more reasonable prices.) ...
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Mebendazole is a highly effective, broad-spectrum antihelmintic indicated for the treatment of nematode infestations, including roundworm, hookworm, whipworm, threadworm, pinworm, and the intestinal form of trichinosis prior to its spread into the tissues beyond the digestive tract. Other drugs are used to treat worm infections outside the digestive tract, as mebendazole is poorly absorbed into the bloodstream. Mebendazole is used alone in those with mild to moderate infestations. It kills parasites relatively slowly, and in those with very heavy infestations, it can cause some parasites to migrate out of the digestive system, leading to appendicitis, bile duct problems, or intestinal perforation. To avoid this, heavily infested patients may be treated with piperazine, either before or instead of mebendazole. Piperazine paralyses the parasites, causing them to pass in the feces. It is also used rarely in the treatment of hydatid disease. Evidence for effectiveness for this disease, however, is ...
The active ingredient in Vermox is Mebendazole and its labeled as an antihelmintic kind of medication. Its used for the purpose of treating whipworm, pinworm, hookworm, roundworm, as well as other worm infections. When taken properly its able to stop worms from absorbng different sugars that they need in order to survive. What this does is it diminishes their energy source and causes them to die out within a few days. The dead worms are them eliminated from the body through stools.. What are some of the minor side effects for Vermox?. There are some minor side effects that could occur, with the main one being headaches or nausea. If you experience minor side effects, continue to take the medication and speak with a medical professional if you start experiencing something more serious such as abdominal pain, diarrhea or fever.. What are some of the more serious side effects? Allergic reactions (swelling of your lips, tongue, or face; shortness of breath; closing of your throat; or ...
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Mebendazole Eradication of infectious disease Neglected tropical diseases Plumb DC (2011). "Albendazole". Plumb's Veterinary ... Trichuriasis (whipworm infection), sometimes considered as an alternative to mebendazole and sometimes considered to be the ... Dayan AD (May 2003). "Albendazole, mebendazole and praziquantel. Review of non-clinical toxicity and pharmacokinetics". Acta ... as an alternative to mebendazole Mansonelliasis when caused by Mansonella perstans. Albendazole works against the adult worms ...
Alternative agents include mebendazole and albendazole. Successful treatment with ivermectin has also been reported. Another ...
The patient gets two mebendazole pills. However, the patient's lungs fill with fluid and become severely compromised. Foreman ...
Treatment is by either thiabendazole or mebendazole. Trichinella infection can be prevented by cooking pork meat properly, or ...
Mebendazole, triclabendazole and fenbendazole are commonly used. Ivermectin and pyrantel pamoate are also effective. The ...
Another treatment that can be used is mebendazole. These medication have been shown to lessen the infection by this parasite ...
Mebendazole at 11 mg/kg, PO, has also been successful. Taking an infected animal to a vet is the best option for ridding a pet ...
In the UK, mebendazole and piperazine are currently (2007) preferred. Mebendazole has a much higher failure rate in clinical ...
Mebendazole and thiabendazole have also both been cited to work. Because the only way of developing acanthocephaliasis is ...
... of children can be carried out by administering mebendazole and albendazole which are two types of anthelmintic ... It involves giving all children doses of Albendazole or Mebendazole. However, in 2013 the Director of the National Institute of ... October 2014). "Assessment of anthelmintic efficacy of mebendazole in school children in six countries where soil-transmitted ... Deworming programmes for children usually administer an anthelmintic drug such as albendazole or mebendazole (or praziquantel ...
Mebendazole can be given with a single dose twice a day for three consecutive days. Albendazole is given at a single dose. WHO ... For this purpose, broad-spectrum benzimidazoles such as mebendazole and albendazole are the drugs of choice recommended by WHO ... The World Health Organizations recommended albendazole or mebendazole for treatment. One strategy to control the disease in ... However, it has been reported that albendazole, mebendazole, and pyrantel pamoate are not entirely effective against T. ...
For this purpose, broad-spectrum benzimidazoles such as mebendazole and albendazole are the drugs of choice recommended by WHO ... Single‐dose of albendazole, mebendazole, and ivermectin are effective against ascariasis. They are effective at removing ... Treatments recommended by the World Health Organization are the medications albendazole, mebendazole, levamisole, or pyrantel ... Those recommended by the World Health Organization for ascariasis are: albendazole, mebendazole, levamisole and pyrantel ...
Benzimidazoles such as mebendazole, parbendazole and thiabendazole are also highly effective. A draft assembly of the genome of ...
Naturally infected hens were dewormed completely in 24 hours using mebendazole orally at doses 25 mg/kg body weight and higher ... Matta SC (1980). "Efficacy of mebendazole (Pantelmin-Ethnor) against some common cestodes of poultry". Indian Journal of ...
... and mebendazole, but lower activity than the combined regimen of mebendazole and DEC. However, more research may be needed into ... Mebendazole and thiabendazole have a greater effect than previously described drugs, but are not sufficient for treatment alone ... Mebendazole, another possible treatment for M. perstans filariasis, has been shown to be effective in significantly reducing ... Combination treatments with DEC and mebendazole have had the most success. In the most recent clinical trials, doxycycline has ...
Children can be treated by administering, for example, mebendazole and albendazole. The cost is relatively low. According to ...
A single 100 milligram dose of mebendazole with one repetition after a week, is considered the safest, and is usually effective ... Treatment is typically with two doses of the medications mebendazole, pyrantel pamoate, or albendazole two weeks apart. ... The benzimidazole compounds albendazole (brand names e.g., Albenza, Eskazole, Zentel and Andazol) and mebendazole (brand names ... with cure rate of 96%. Mebendazole has no serious side effects, although abdominal pain and diarrhea have been reported. ...
Chotmongkol V (2006). "Treatment of eosinophilic meningitis with a combination of prednisolone and mebendazole". Am J Trop Med ...
In humans, treatment is by anthelminthic medications, such as albendazole and mebendazole. Treatment in animals can be done ...
Albendazole, ivermectin, mebendazole, and pyrantel are all commonly used, though albendazole is usually the drug of choice. ... Studies suggest that a two-week regimen of a combination of mebendazole and prednisolone significantly shortened the course of ... 2006). "Treatment of Eosinophilic Meningitis with a Combination of Prednisolone and Mebendazole". Am. J. Trop. Med. Hyg. 74 (6 ...
In humans, mebendazole (200-400 mg three times a day for three days) or albendazole (400 mg twice a day for 8-14 days) is given ... Infection is typically treated with antiparasitic medication such as albendazole or mebendazole. Rapid treatment may kill adult ... Retrieved 2009-08-23.CS1 maint: archived copy as title (link) "Monograph - Mebendazole". medscape.com. Retrieved 2009-02-24. Gu ... Early administration of anthelmintics, such as mebendazole or albendazole, decreases the likelihood of larval encystation, ...
The drugs of choice for soil-transmitted helminths are mebendazole and albendazole; for schistosomiasis and tapeworms it is ... Benzimidazoles: Albendazole - effective against threadworms, roundworms, whipworms, tapeworms, hookworms Mebendazole - ... "Assessment of Anthelmintic Efficacy of Mebendazole in School Children in Six Countries Where Soil-Transmitted Helminths Are ...
Humans infested with C. aerophila have been successfully treated with albendazole and mebendazole. For animals kept in outdoor ...
... mebendazole, levamisole and pyrantel pamoate. Oxyclozanide, hexachlorophene and nitroxynil are also highly effective. F. buski ... mebendazole, levamisole, pyrantel pamoate, hexylresorcinol and tetrachloroethylene". Trans R Soc Trop Med Hyg. 79 (4): 513-5. ...
While albendazole is the preferred drug, mebendazole can also be used if the treatment is to be for an extended period of time ... An alternative to albendazole is mebendazole for at least 3 to 6 months. The other alternative to surgery is PAIR with ... People who undergo PAIR typically take albendazole or mebendazole from 7 days before the procedure until 28 days after the ... In treatment using just chemotherapy, one could use either mebendazole in three doses or albendazole in two doses. Since ...
Mebendazole and nitroscanate are also products that have efficacy against taeniataeniaeformis in cats. Little, S. (2011). The ...
Cedillo-Rivera R, Muñoz O (September 1992). "In-vitro susceptibility of Giardia lamblia to albendazole, mebendazole and other ...
V. Field trial on evaluation of therapeutic efficacy of mebendazole and praziquantel against taeniasis". The Southeast Asian ...
Many anthelmintic drugs (albendazole, mebendazole, triclabendazole etc.) belong to the benzimidazole class of compounds. ...
May 2020). "Identification of Atovaquone, Ouabain and Mebendazole as FDA-Approved Drugs Targeting SARS-CoV-2". chemRxiv ( ...
Mebendazole is a broad-spectrum antihelminthic agent of the benzimidazole type. Mebendazole came into use in 1971, after it was ... Mebendazole is available as a generic medication. Mebendazole is distributed in international markets by Johnson and Johnson ... Mebendazole is available as a generic medication. Mebendazole is a highly effective, broad-spectrum antihelmintic indicated for ... "Mebendazole". Archived from the original on 2016-10-23. Retrieved 2016-04-29. "Mebendazole". The American Society of Health- ...
Mebendazole is available as a generic medication.[6] Mebendazole is distributed in international markets by Johnson and Johnson ... Carbamazepine and phenytoin lower serum levels of mebendazole. Cimetidine does not appreciably raise serum mebendazole (in ... "Mebendazole". International Drug Price Indicator Guide. Archived from the original on 5 March 2017. Retrieved 18 August 2015.. ... "Treatment of hydatid disease with high oral doses of mebendazole. Long-term follow-up of plasma mebendazole levels and drug ...
Mebendazole: learn about side effects, dosage, special precautions, and more on MedlinePlus ... When mebendazole (Emverm) is used to treat pinworm, it is usually taken as a single (one-time) dose. Mebendazole (Vermox) is ... Before taking mebendazole,. *tell your doctor and pharmacist if you are allergic to mebendazole, any other medications, or any ... Mebendazole is used to treat several types of worm infections. Mebendazole (Vermox) is used to treat roundworm and whipworm ...
Ovex OTC mebendazole is available to buy from pharmacies. ... The safety of mebendazole for use during pregnancy has not been ... Read more about the using mebendazole during pregnancy here. Is it safe to use Vermox if breastfeeding? Mebendazole passes into ... Mebendazole is not known to affect other medicines. However, it may be best to It may be best to avoid taking cimetidine with ... Although mebendazole kills the adult worms it doesnt kill their eggs, so its really important to be very thorough with ...
A list of US medications equivalent to Mebendazole is available on the Drugs.com website. ... Mebendazole is a medicine available in a number of countries worldwide. ... Exelmin (Mebendazole and Cambendazole). UCI, Brazil. *Flukiver Combi (Mebendazole and Closantel (veterinary use)). Elanco, ... In the US, Mebendazole (mebendazole systemic) is a member of the drug class anthelmintics and is used to treat ...
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Its called mebendazole and "Big Pharma" hopes you will never hear about it.. Mebendazole (MBZ). If you have ever cared for ... His disease subsequently progressed after 24 months of mebendazole monotherapy. Conclusion: Mebendazole may achieve long-term ... As promised -- here are some references for further research of mebendazole:. The Anthelmintic Drug Mebendazole Induces Mitotic ... Mebendazole has been approved by the US Food and Drug Administration for parasitic infections, has a long track-record of safe ...
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Mebendazole is used to treat infections caused by worms such as whipworm, pinworm, roundworm, and hookworm. It is also used to ... Mebendazole is an anthelmintic (an-thel-MIN-tik) or anti-worm medication. It prevents newly hatched insect larvae (worms) from ... What is mebendazole?. Mebendazole is an anthelmintic (an-thel-MIN-tik) or anti-worm medication. It prevents newly hatched ... What should I discuss with my healthcare provider before taking mebendazole?. You should not use mebendazole if you are ...
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The active ingredients are Closantel (5mg/ml) and Mebendazole (75mg/ml).. Mebendazole:. Mebendazole belongs to the chemical ... SupaVerm Closantel Mebendazole Against Flukes Closantel/Mebendazole combination. Erik L. Johnson, D.V.M. Fish Health Specialist ... The active ingredients in Fluke Tabs are Trichlorfon and Mebendazole. Doc Johnson. The presence of Mebendazole in the Fluke ... There appears to be no negative effect of Closantel/Mebendazole combination on Koi. Closantel/Mebendazole combination was 100% ...
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... mebendazole) includes side effects, uses, drug interactions, dosage, drug pictures, overdose symptoms, and what to avoid. ... Generic Name: mebendazole. *What is mebendazole (Emverm, Vermox)?. *What are the possible side effects of mebendazole (Emverm, ... Mebendazole is used to treat infections caused by worms such as whipworm, pinworm, roundworm, and hookworm. It is also used to ... Mebendazole can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine. ...
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Hi Dr Hale Is it ok for both my infant and I to take the 500 mg once off single dose of Mebendazole ( Vermox) together? She has ... Mebendazole 500 mg single dose. Hi Dr Hale. Is it ok for both my infant and I to take the 500 mg once off single dose of ... Mebendazole ( Vermox) together? She has had hers already and shes fine. I still need to take mine but Im sure if its ok for ...
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  • If you are taking mebendazole (Emverm) chewable tablets, you may chew the tablets, swallow them whole, or crush and mix them with food. (medlineplus.gov)
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  • Vermox tablets and suspension contain mebendazole as the active ingredient, which is a type of medicine called an anthelmintic. (netdoctor.co.uk)
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  • that mebendazole (MZ), a derivative of benzimidazole, induces a dose- and time-dependent apo-ptotic response in human lung cancer cell lines. (it-4u.eu)
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  • The purpose of this study was to evaluate the in vitro chemosensitivity of canine glioma J3T cells to mebendazole and fenbendazole. (auburn.edu)
  • The mean IC50 (+/- SD) obtained from performing the MTT [3-(4,5-dimethylthiazol-2- yl)-2,5-diphenyltetrazolium bromide] assay after treating J3T cells for 72 hours with mebendazole and fenbendazole were 0.030 +/- 0.003 and 0.550 +/- 0.015 μM respectively. (auburn.edu)
  • Mebendazole and fenbendazole are cytotoxic in canine glioma J3T cells in vitro and may be good candidates for treatment of canine gliomas. (auburn.edu)
  • Further in vivo studies evaluating pharmacokinetics of mebendazole and fenbendazole in the cerebrospinal fluid and subsequent antitumoral efficacy are indicated. (auburn.edu)
  • Cestodes (tapeworms), as an alternative to praziquantel or niclosamide for adult beef tapeworms (Taenia saginata) and as an alternative to praziquantel for pork tapeworms (T. In the same group of drugs as Mebendazole, a group called benzimidazoles, there is another anti-worm drug called Fenbendazole. (incommunity.it)
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  • Mebendazole is a highly effective, broad-spectrum antihelmintic indicated for the treatment of nematode infestations, including roundworm, hookworm, whipworm, threadworm, pinworm, and the intestinal form of trichinosis prior to its spread into the tissues beyond the digestive tract. (wikipedia.org)
  • When mebendazole (Emverm) is used to treat pinworm, it is usually taken as a single (one-time) dose. (medlineplus.gov)
  • Mebendazole is used to treat parasitic infections and worm infections such as pinworm, threadworm, whipworm, hookworm and tapeworm that infect the large intestine. (mims.com)
  • Mebendazole (MBZ) is a drug developed to treat human helminthic disease and is FDA-approved for the treatment of roundworm, common hookworm, American hookworm, pinworm and whipworm. (clinicaltrials.gov)
  • Mebendazole Suspension is a medicine that is used for the treatment of Stomach Infections, Intestinal Infections, Threadworm Infection, Pinworm Infection, Roundworm Infection, Whipworm Infection and other conditions. (aviencepharma.com)
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  • Stevens-Johnson syndrome and the more severe toxic epidermal necrolysis can occur when mebendazole is combined with high doses of metronidazole. (wikipedia.org)
  • Stevens-Johnson syndrome (toxic epidermal necrolysis) when mebendazole is combined with high doses of metronidazole. (thefullwiki.org)
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  • The purpose of this study is to determine the safety and side effects for increasing doses of mebendazole, followed by the treatment of an additional 12 patients at the best tolerated dose. (clinicaltrials.gov)
  • This trial completed the maximum approved enrollment of 24 patients treated with mebendazole, with high doses consistent with dosing published for severe parasitic infections. (clinicaltrials.gov)
  • A patient with chronic liver disease was treated with large doses of mebendazole for a hepatic hydatid cyst. (ajtmh.org)
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  • Carbamazepine and phenytoin lower serum levels of mebendazole. (wikipedia.org)
  • Secondary Objectives of the study include to determine the safety, tolerability and toxicity of mebendazole in this patient population, determine the plasma levels of mebendazole in this patient population and Determine progression-free and overall survival of mebendazole in an extended cohort of patients with treatment refractory pediatric brain cancer. (clinicaltrials.gov)
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  • To investigate this, we examined the effects of mebendazole on GL261 glioblastoma cell viability, microtubule polymerization and metaphase arrest, and found that the effective concentrations to inhibit these functions are very similar. (molmed.org)
  • Our data provide evidence that the antineoplastic effects of mebendazole in human melanoma cells result from differential Bcl-2-mediated cellular responses to mebendazole-induced tubulin disruption. (aacrjournals.org)
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  • Laboratory studies indicate that mebendazole enters the brain and brain tumors at concentrations that may be effective for a combination of anti-cancer mechanisms. (clinicaltrials.gov)
  • These preclinical findings indicate that mebendazole alone or in combination with radiation can be considered for the treatment of malignant meningioma. (virtualtrials.com)
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  • I have been taking either Dicaris (Levamisole) or Mebex (Mebendazole). (ndtv.com)
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  • you should know that in addition to your treatment with mebendazole, you will need to take steps to prevent reinfection and infection of other people. (medlineplus.gov)
  • Mebendazole will not treat a viral infection such as the flu or a common cold. (wellspan.org)
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  • Trichuriasis (whipworm infection), sometimes considered as an alternative to mebendazole and sometimes considered to be the drug of choice. (wikipedia.org)
  • Mebendazole works to harm the worms and fight the infection. (rlcglobe.com)
  • Mebendazole works by selectively inhibiting the synthesis of microtubules via binding to colchicine binding site of β-tubulin, thereby blocking polymerisation of tubulin dimers in intestinal cells of parasites. (wikipedia.org)
  • Mebendazole is highly selective and somehow targets only cancerous cells (as well as a host of intestinal parasites). (viewzone.com)
  • Mebendazole Suspension works by inhibiting glucose uptake by larvae of parasites. (aviencepharma.com)
  • Children sometimes acquire these parasites (adults can as well), and the whole family is given a prescription for mebendazole. (meble-knop.pl)
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  • Other drugs are used to treat worm infections outside the digestive tract, as mebendazole is poorly absorbed into the bloodstream. (wikipedia.org)
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  • Mebendazole is used to treat several types of worm infections. (medlineplus.gov)
  • Mebendazole (Vermox) is used to treat roundworm and whipworm infections. (medlineplus.gov)
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  • The half maximal inhibitory concentration (IC50) effect on colony formation, cell proliferation, and caspase-3/7 markers of apoptosis of mebendazole with and without radiation was measured in vitro. (virtualtrials.com)
  • In vitro experiments on meningioma cell lines showed the IC50 for mebendazole in the range of 0.26-0.42 µM. (virtualtrials.com)
  • Mebendazole is thought to work by selectively inhibiting the synthesis of microtubules in parasitic worms, and by destroying extant cytoplasmic microtubules in their intestinal cells, thereby blocking the uptake of glucose and other nutrients, resulting in the gradual immobilization and eventual death of the helminths. (wikipedia.org)
  • Vermox contains mebendazole which works by preventing worms from being able to absorb sugars that are essential for their survival. (netdoctor.co.uk)
  • Although mebendazole kills the adult worms it doesn't kill their eggs, so it's really important to be very thorough with hygiene, even after you've taken the treatment. (netdoctor.co.uk)
  • Mebendazole is thought to cause slow immobilization and death of the worms by selectively inhibiting the synthesis of microtubules. (thefullwiki.org)
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  • To further characterize the effects of the drug a random C. gattii mutant library was screened and indicated that the antifungal activity of mebendazole requires previously unknown cryptococcal targets. (frontiersin.org)
  • Antitumor activity of mebendazole has been previously described in lung and adrenocortical carcinomas ( 5 , 6 ). (aacrjournals.org)
  • Taken together, these results indicate that the cell toxicity of mebendazole is indeed caused by inhibiting microtubule formation. (molmed.org)
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  • Our study describes the therapeutic utility and mechanism of action of mebendazole, one of the compounds identified from this screen as an antimelanoma agent. (aacrjournals.org)
  • The inhibition by metronidazole of survival of unilocular hydatid protoscoleces was similar to that of mebendazole. (eurekamag.com)
  • No side‐effects were observed in the mebendazole‐treated group, whereas nausea, anorexia and metallic taste were observed in 4.9, 6 and 24 per cent of metronidazole‐treated children, respectively. (oup.com)
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  • The primary objectives of this study are to determine the maximum tolerated dose (MTD) of oral mebendazole in patients with recurrent/progressive pediatric brain tumors and to confirm the tolerance of the MTD of oral mebendazole by assessing tolerance in a dose expansion cohort. (clinicaltrials.gov)
  • Mebendazole may cause side effects. (medlineplus.gov)
  • The following are some of the side effects that are known to be associated with mebendazole. (netdoctor.co.uk)
  • Mebendazole may cause any of the following side effects: itching, vomiting, diarrhoea, stomach discomfort and rash. (mims.com)
  • The manufacturer's leaflet will give you more information about mebendazole and a full list of the side-effects which you may experience from taking it. (patient.info)
  • In conclusion, the use of mebendazole, which is less toxic with no side‐effects, is available and effective on Giardia intestinalis as well as intestinal nematodes, is recommended especially in the areas where giardiasis and intestinal nematodiasis are prevalent and overlap. (oup.com)
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  • Mebendazole kills cancer cells, even those that are unresponsive to other chemotherapy, without causing harm to normal cells, and with little or no side effects. (org.in)
  • However mebendazole has impact on mammalian cells mostly by inhibiting polymeration of tubulin dimers, thereby disrupting essential microtubule structures such as mitotic spindle. (wikipedia.org)
  • We further show that mebendazole-resistant melanocytes can be sensitized through reduction of Bcl-2 protein levels, showing the essential role of Bcl-2 in the cellular response to mebendazole-mediated tubulin disruption. (aacrjournals.org)
  • Furthermore, mebendazole has been shown to induce depolymerization of tubulin in a variety of cancer models ( 6 , 7 ). (aacrjournals.org)
  • In conclusion, our results strongly support the clinical use of mebendazole as a replacement for vincristine for the treatment of brain tumors. (molmed.org)
  • The intrinsic apoptotic response is mediated through phosphorylation of Bcl-2, which occurs rapidly after treatment with mebendazole in melanoma cells but not in melanocytes. (aacrjournals.org)
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  • Cimetidine does not appreciably raise serum mebendazole (in contrast to the similar drug albendazole), consistent with its poor systemic absorption. (wikipedia.org)
  • Cimetidine raises serum mebendazole levels, increasing its effectiveness. (thefullwiki.org)
  • Mebendazole, also known as Telmintic, is a anthelmentic dewormer that is used to treat hookworms, roundworms (ascarid type), whipworms and one type of tapeworm (not effective in fighting flea tapeworms). (cuteness.com)
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