Exposure of the female parent, human or animal, to potentially harmful chemical, physical, or biological agents in the environment or to environmental factors that may include ionizing radiation, pathogenic organisms, or toxic chemicals that may affect offspring. It includes pre-conception maternal exposure.
The consequences of exposing the FETUS in utero to certain factors, such as NUTRITION PHYSIOLOGICAL PHENOMENA; PHYSIOLOGICAL STRESS; DRUGS; RADIATION; and other physical or chemical factors. These consequences are observed later in the offspring after BIRTH.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
Exchange of substances between the maternal blood and the fetal blood at the PLACENTA via PLACENTAL CIRCULATION. The placental barrier excludes microbial or viral transmission.
An acute leukemia exhibiting cell features characteristic of both the myeloid and lymphoid lineages and probably arising from MULTIPOTENT STEM CELLS.
Hair grooming, cleansing and modifying products meant for topical application to hair, usually human. They include sprays, bleaches, dyes, conditioners, rinses, shampoos, nutrient lotions, etc.
Exposure of the male parent, human or animal, to potentially harmful chemical, physical, or biological agents in the environment or to environmental factors that may include ionizing radiation, pathogenic organisms, or toxic chemicals that may affect offspring.
Compounds which contain the methyl radical substituted with two benzene rings. Permitted are any substituents, but ring fusion to any of the benzene rings is not allowed.
Any substance in the air which could, if present in high enough concentration, harm humans, animals, vegetation or material. Substances include GASES; PARTICULATE MATTER; and volatile ORGANIC CHEMICALS.
An infant during the first month after birth.
A triazine herbicide.
Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.
Substances or energies, for example heat or light, which when introduced into the air, water, or land threaten life or health of individuals or ECOSYSTEMS.
The unborn young of a viviparous mammal, in the postembryonic period, after the major structures have been outlined. In humans, the unborn young from the end of the eighth week after CONCEPTION until BIRTH, as distinguished from the earlier EMBRYO, MAMMALIAN.
Morphological and physiological development of FETUSES.
Benzene derivatives that include one or more hydroxyl groups attached to the ring structure.
The age of the conceptus, beginning from the time of FERTILIZATION. In clinical obstetrics, the gestational age is often estimated as the time from the last day of the last MENSTRUATION which is about 2 weeks before OVULATION and fertilization.
Dyes used as cosmetics to change hair color either permanently or temporarily.
Congenital defect in the upper lip where the maxillary prominence fails to merge with the merged medial nasal prominences. It is thought to be caused by faulty migration of the mesoderm in the head region.
A synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. It was also used formerly as a growth promoter in animals. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), diethylstilbestrol has been listed as a known carcinogen. (Merck, 11th ed)
An infant having a birth weight of 2500 gm. (5.5 lb.) or less but INFANT, VERY LOW BIRTH WEIGHT is available for infants having a birth weight of 1500 grams (3.3 lb.) or less.
The beginning third of a human PREGNANCY, from the first day of the last normal menstrual period (MENSTRUATION) through the completion of 14 weeks (98 days) of gestation.
A chemical by-product that results from burning or incinerating chlorinated industrial chemicals and other hydrocarbons. This compound is considered an environmental toxin, and may pose reproductive, as well as, other health risks for animals and humans.
Contamination of the air by tobacco smoke.
Industrial products consisting of a mixture of chlorinated biphenyl congeners and isomers. These compounds are highly lipophilic and tend to accumulate in fat stores of animals. Many of these compounds are considered toxic and potential environmental pollutants.
Congenital fissure of the soft and/or hard palate, due to faulty fusion.
The failure of a FETUS to attain its expected FETAL GROWTH at any GESTATIONAL AGE.
The exposure to potentially harmful chemical, physical, or biological agents in the environment or to environmental factors that may include ionizing radiation, pathogenic organisms, or toxic chemicals.
Toxic, volatile, flammable liquid hydrocarbon byproduct of coal distillation. It is used as an industrial solvent in paints, varnishes, lacquer thinners, gasoline, etc. Benzene causes central nervous system damage acutely and bone marrow damage chronically and is carcinogenic. It was formerly used as parasiticide.
Nitrogen oxide (NO2). A highly poisonous gas. Exposure produces inflammation of lungs that may only cause slight pain or pass unnoticed, but resulting edema several days later may cause death. (From Merck, 11th ed) It is a major atmospheric pollutant that is able to absorb UV light that does not reach the earth's surface.
The processes of milk secretion by the maternal MAMMARY GLANDS after PARTURITION. The proliferation of the mammary glandular tissue, milk synthesis, and milk expulsion or let down are regulated by the interactions of several hormones including ESTRADIOL; PROGESTERONE; PROLACTIN; and OXYTOCIN.
The presence of contaminants or pollutant substances in the air (AIR POLLUTANTS) that interfere with human health or welfare, or produce other harmful environmental effects. The substances may include GASES; PARTICULATE MATTER; or volatile ORGANIC CHEMICALS.
Non-steroidal compounds with estrogenic activity.
Conditions or pathological processes associated with pregnancy. They can occur during or after pregnancy, and range from minor discomforts to serious diseases that require medical interventions. They include diseases in pregnant females, and pregnancies in females with diseases.
Exogenous agents, synthetic and naturally occurring, which are capable of disrupting the functions of the ENDOCRINE SYSTEM including the maintenance of HOMEOSTASIS and the regulation of developmental processes. Endocrine disruptors are compounds that can mimic HORMONES, or enhance or block the binding of hormones to their receptors, or otherwise lead to activating or inhibiting the endocrine signaling pathways and hormone metabolism.
CHILDBIRTH before 37 weeks of PREGNANCY (259 days from the first day of the mother's last menstrual period, or 245 days after FERTILIZATION).
The mass or quantity of heaviness of an individual at BIRTH. It is expressed by units of pounds or kilograms.
Results of conception and ensuing pregnancy, including LIVE BIRTH; STILLBIRTH; SPONTANEOUS ABORTION; INDUCED ABORTION. The outcome may follow natural or artificial insemination or any of the various ASSISTED REPRODUCTIVE TECHNIQUES, such as EMBRYO TRANSFER or FERTILIZATION IN VITRO.
A developmental defect in which a TESTIS or both TESTES failed to descend from high in the ABDOMEN to the bottom of the SCROTUM. Testicular descent is essential to normal SPERMATOGENESIS which requires temperature lower than the BODY TEMPERATURE. Cryptorchidism can be subclassified by the location of the maldescended testis.
The measurement of an organ in volume, mass, or heaviness.
A major group of unsaturated cyclic hydrocarbons containing two or more rings. The vast number of compounds of this important group, derived chiefly from petroleum and coal tar, are rather highly reactive and chemically versatile. The name is due to the strong and not unpleasant odor characteristic of most substances of this nature. (From Hawley's Condensed Chemical Dictionary, 12th ed, p96)
Chemicals used to destroy pests of any sort. The concept includes fungicides (FUNGICIDES, INDUSTRIAL); INSECTICIDES; RODENTICIDES; etc.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
A highly vascularized mammalian fetal-maternal organ and major site of transport of oxygen, nutrients, and fetal waste products. It includes a fetal portion (CHORIONIC VILLI) derived from TROPHOBLASTS and a maternal portion (DECIDUA) derived from the uterine ENDOMETRIUM. The placenta produces an array of steroid, protein and peptide hormones (PLACENTAL HORMONES).
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
Refers to animals in the period of time just after birth.
The ratio of two odds. The exposure-odds ratio for case control data is the ratio of the odds in favor of exposure among cases to the odds in favor of exposure among noncases. The disease-odds ratio for a cohort or cross section is the ratio of the odds in favor of disease among the exposed to the odds in favor of disease among the unexposed. The prevalence-odds ratio refers to an odds ratio derived cross-sectionally from studies of prevalent cases.
Chemical compounds which pollute the water of rivers, streams, lakes, the sea, reservoirs, or other bodies of water.
The total process by which organisms produce offspring. (Stedman, 25th ed)
The male gonad containing two functional parts: the SEMINIFEROUS TUBULES for the production and transport of male germ cells (SPERMATOGENESIS) and the interstitial compartment containing LEYDIG CELLS that produce ANDROGENS.
The process of bearing developing young (EMBRYOS or FETUSES) in utero in non-human mammals, beginning from FERTILIZATION to BIRTH.
Blood of the fetus. Exchange of nutrients and waste between the fetal and maternal blood occurs via the PLACENTA. The cord blood is blood contained in the umbilical vessels (UMBILICAL CORD) at the time of delivery.
Female parents, human or animal.
Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
The exposure to potentially harmful chemical, physical, or biological agents that occurs as a result of one's occupation.
Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Inhaling and exhaling the smoke of burning TOBACCO.
Elements of limited time intervals, contributing to particular results or situations.

The role of domestic factors and day-care attendance on lung function of primary school children. (1/1469)

The results of studies examining the relationship of domestic factors to lung function are contradictory. We therefore examined the independent effects of maternal smoking during pregnancy, exposure to environmental tobacco smoke (ETS), the presence of a cat, type of heating and cooking used in the home and day-care attendance on lung function after controlling for socioeconomic status (SES). Nine hundred and eighty-nine children from 18 Montreal schools were studied between April 1990 and November 1992. Information on the child's health and exposure to domestic factors was collected by questionnaire. Spirometry was performed at school. The data were analysed by multiple linear regression with percent predicted FEV1, FVC, and FEV1/FVC as dependent variables. In the overall sample (both sexes combined), cat in the home (regression coefficient, beta = -1.15, 95% confidence interval, CI: -2.26-(-)0.05) and electric baseboard units (beta = -1.26, 95% CI: -2.39-(-)0.13) were independently associated with a lower FEV1/FVC, while day-care attendance (beta = -2.05, 95% CI: -3.71-(-)0.40) significantly reduced FEV1. Household ETS was significantly associated with increasing level of FVC (beta = 2.86, 95% CI: +0.55 to +5.17). In boys but not girls, household ETS (beta = -2.13, 95% CI: -4.07-(-)0.19) and the presence of a cat (beta = -2.19, 95% CI: -3.94-(-)0.45) were associated with lower FEV1/FVC. By contrast, day-care attendance was associated with lower FEV1 (beta = -2.92, 95% CI: -5.27-(-)0.56) and FEV1/FVC (beta = -1.53, 95% CI: -2.73-(-)0.33) in girls only. In conclusion, the results provide evidence that domestic factors and day-care attendance primarily affected airway caliber and gender differences were apparent in the effects of these factors.  (+info)

Immunosurgical studies on cytological and cytogenetic toxicity analysis of rat blastocysts after in vivo exposure to cyclophosphamide. (2/1469)

AIM: To establish immunosurgery and indices of cytogenetic assessment for blastocyst and its inner cell mass (ICM), and to evaluate the toxic effects after in vivo exposure to cyclophosphamide. METHODS: Modified immunosurgery was established by preparation of rabbit-anti-rat spleen antiserum and induction of diluted rat mixed serum as complement. Pregnant rats on d 3 of gestation were injected i.p. cyclophosphamide (10, 20, and 40 mg.kg-1). On d 4, immunosurgery was performed on rat blastocysts. The cell number and the micronuclei of blastocyst and ICM were evaluated respectively. RESULTS: In the cyclophosphamide-treated rats, decreases of cell number (35 +/- 3, 32 +/- 1, 30 +/- 1, and 14 +/- 2, 11 +/- 1, 9 +/- 2) and increases of frequency of micronuclei (1.81%, 2.27%, 3.14%, and 2.53%, 2.98%, 4.75%) in blastocysts and ICM were observed in a dose-related manner. The changes of blastocyst were, however, not parallel to those of ICM which were more serious. CONCLUSION: Modified immunosurgery, an objective and elegant technique, was used on rat blastocysts. In vivo could cyclophosphamide injured ICM more than blastocysts.  (+info)

Prenatal nicotine increases pulmonary alpha7 nicotinic receptor expression and alters fetal lung development in monkeys. (3/1469)

It is well established that maternal smoking during pregnancy is a leading preventable cause of low birth weight and prematurity. Less appreciated is that maternal smoking during pregnancy is also associated with alterations in pulmonary function at birth and greater incidence of respiratory illnesses after birth. To determine if this is the direct result of nicotine interacting with nicotinic cholinergic receptors (nAChRs) during lung development, rhesus monkeys were treated with 1 mg/kg/day of nicotine from days 26 to 134 of pregnancy. Nicotine administration caused lung hypoplasia and reduced surface complexity of developing alveoli. Immunohistochemistry and in situ alpha-bungarotoxin (alphaBGT) binding showed that alpha7 nAChRs are present in the developing lung in airway epithelial cells, cells surrounding large airways and blood vessels, alveolar type II cells, free alveolar macrophages, and pulmonary neuroendocrine cells (PNEC). As detected both by immunohistochemistry and by alphaBGT binding, nicotine administration markedly increased alpha7 receptor subunit expression and binding in the fetal lung. Correlating with areas of increased alpha7 expression, collagen expression surrounding large airways and vessels was significantly increased. Nicotine also significantly increased numbers of type II cells and neuroendocrine cells in neuroepithelial bodies. These findings demonstrate that nicotine can alter fetal monkey lung development by crossing the placenta to interact directly with nicotinic receptors on non-neuronal cells in the developing lung, and that similar effects likely occur in human infants whose mothers smoke during pregnancy.  (+info)

Twins and maternal smoking: ordeals for the fetal origins hypothesis? A cohort study. (4/1469)

OBJECTIVE: To assess the direct and indirect effects of being a twin, maternal smoking, birth weight, and mother's height on blood pressure at ages 9 and 18 years. DESIGN: Longitudinal study. SUBJECTS: Cohort born in 1972-3. SETTING: Dunedin, New Zealand. MAIN OUTCOME MEASURE: Blood pressure at ages 9 and 18 years. RESULTS: Compared with singletons, twins had a systolic blood pressure 4.55 (95% confidence interval 1.57 to 7.52) mm Hg lower at age 9 after adjustment for direct and indirect effects of sex, maternal smoking, mother's height, socioeconomic status, and birth weight, as well as concurrent height and body mass index. Blood pressure in children whose mothers had smoked during pregnancy was 1.54 (0.46 to 2.62) mm Hg higher than in those whose mothers did not. The total effect of birth weight on systolic blood pressure at age 9 was -0.78 (-1.76 to 0.20) mm Hg and that for mother's height was 0.10 (0.06 to 0.14) mm Hg. Similar results were obtained for systolic blood pressure at age 18. The total effect of twins, maternal smoking, and birth weight on diastolic blood pressure was not significant at either age. CONCLUSIONS: Twins had lower birth weight and lower systolic blood pressure at ages 9 and 18 than singletons. This finding challenges the fetal origins hypothesis. The effect of maternal smoking was consistent with the fetal origin hypothesis in that the infants of smokers were smaller and had higher blood pressure at both ages. This may be explained by pharmacological rather than nutritional effects. The total effect of birth weight on systolic blood pressure, after its indirect effect working through concurrent measures of height and body mass index was taken into account, was small.  (+info)

Tobacco smoke exposure at one month of age and subsequent risk of SIDS--a prospective study. (5/1469)

The aim of this investigation was to identify the sources of postnatal exposure to tobacco smoke at 1 month of age and to examine their relation to sudden infant death syndrome (SIDS). The Tasmanian Infant Health Survey was a prospective cohort study undertaken from 1988 to 1995. It involved 9,826 infants (89% of eligible infants) at higher risk of SIDS. Subsequently 53 eligible infants died of SIDS. Hospital interviews were available on 51 and home interviews on 35 SIDS infants. Urinary cotinine assays were conducted using gas-liquid chromatography (n = 100). Within a predictive model that explained 63% of urinary cotinine variance, the strongest predictor of cotinine and also of SIDS was maternal smoking, though the effects of prenatal and postnatal smoking could not be separated. However, for particular smoking-related behaviors, there was a discordance between prediction of cotinine concentration and prediction of risk of SIDS. If smoking mothers did not smoke in the room with the baby, the cotinine level in the infant's urine was reduced by a little more than a half (p = 0.009), but this was not associated with a reduction in SIDS risk (odds ratio = 1.09, 95% confidence interval 0.47-2.55). Similarly, the presence of other adult resident smokers was associated with a 63% increase in urinary cotinine (p = 0.047) but not with increased SIDS risk (odds ratio = 0.69, 95% confidence interval 0.34-1.40). However, the study lacked the power to detect modest effects, that is, those altering risk less than twofold.  (+info)

Fetal growth and maternal exposure to particulate matter during pregnancy. (6/1469)

Prior studies reported an association between ambient air concentrations of total suspended particles and SO2 during pregnancy and adverse pregnancy outcomes. We examined the possible impact of particulate matter up to 10 microm (PM10) and up to 2.5 microm (PM2. 5) in size on intrauterine growth retardation (IUGR) risk in a highly polluted area of Northern Bohemia (Teplice District). The study group includes all singleton full-term births of European origin over a 2-year period in the Teplice District. Information on reproductive history, health, and lifestyle was obtained from maternal questionnaires. The mean concentrations of pollutants for each month of gestation were calculated using continuous monitoring data. Three intervals (low, medium, and high) were constructed for each pollutant (tertiles). Odds ratios (ORs) for IUGR for PM10 and PM2.5 levels were generated using logistic regression for each month of gestation after adjustment for potential confounding factors. Adjusted ORs for IUGR related to ambient PM10 levels in the first gestational month increased along the concentration intervals: medium 1.62 [95% confidence interval (CI), 1.07-2.46], high 2.64 (CI, 1.48-4.71). ORs for PM2.5 were 1.26 (CI, 0.81-1.95) and 2.11 (CI, 1. 20-3.70), respectively. No other associations of IUGR risk with particulate matter were found. Influence of particles or other associated air pollutants on fetal growth in early gestation is one of several possible explanations of these results. Timing of this effect is compatible with a current hypothesis of IUGR pathogenesis. Seasonal factors, one of the other possible explanations, is less probable. More investigation is required to examine these findings and alternative explanations.  (+info)

Cancer in children of nuclear industry employees: report on children aged under 25 years from nuclear industry family study. (7/1469)

OBJECTIVE: To determine whether children of men and women occupationally exposed to ionising radiation are at increased risk of developing leukaemia or other cancers before their 25th birthday. DESIGN: Cohort study of children of nuclear industry employees. SETTING: Nuclear establishments operated by the Atomic Energy Authority, Atomic Weapons Establishment, and British Nuclear Fuels. SUBJECTS: 39 557 children of male employees and 8883 children of female employees. MAIN OUTCOME MEASURES: Cancer incidence in offspring reported by parents. Employment and radiation monitoring data (including annual external dose) supplied by the nuclear authorities. RESULTS: 111 cancers were reported, of which 28 were leukaemia. The estimated standardised incidence ratios for children of male and female employees who were born in 1965 or later were 98 (95% confidence interval 73 to 129) and 96 (50 to 168) for all malignancies and 109 (61 to 180) and 95 (20 to 277) for leukaemia. The leukaemia rate in children whose fathers had accumulated a preconceptual dose of >/=100 mSv was 5.8 times that in children conceived before their fathers' employment in the nuclear industry (95% confidence interval 1.3 to 24.8) but this was based on only three exposed cases. Two of these cases were included in the west Cumbrian ("Gardner") case-control study. No significant trends were found between increasing dose and leukaemia. CONCLUSIONS: Cancer in young people is rare, and our results are based on small numbers of events. Overall, the findings suggest that the incidence of cancer and leukaemia among children of nuclear industry employees is similar to that in the general population. The possibility that exposure of fathers to relatively high doses of ionising radiation before their child's conception might be related to an increased risk of leukaemia in their offspring could not be disproved, but this result was based on only three cases, two of which have been previously reported. High conceptual doses are rare, and even if the occupational association were causal, the number of leukaemias involved would be small; in this study of over 46 000 children, fewer than three leukaemias could potentially be attributed to such an exposure.  (+info)

Tryptophan ingestion by pregnant rats induces pituitary and mammary tumours in the adult female offspring. (8/1469)

The present study was designed to evaluate the long-term consequences of tryptophan treatment on the central serotonergic activity in the female offspring of rats, and particularly on serotonin-controlled hormone release. During the second half of gestation, tryptophan (200 mg/kg/day) was given daily by stomach intubation to pregnant rats and the brain concentrations of serotonin and 5-hydroxyindole acetic acid and the plasma concentrations of prolactin, progesterone, oestradiol and luteinizing hormone were quantified in the adult female offspring. The offspring showed an increase in hypothalamic serotonin and serum progesterone and prolactin. In addition, maternal ingestion of tryptophan induced a marked rise in 665-day-old offspring in the incidence of both pituitary prolactinomas (62%) and mammary adenomas (49%). Present data suggest that tryptophan regulates serotonergic differentiation during early development. A transitory modification of the tryptophan concentration in the fetal brain induces a permanent increase in hypothalamic serotonin level and, in addition to modifying the release of prolactin, increases the incidence of tumours in the hypophysis and mammary gland.  (+info)

We appreciate the interest of Dr. Garlant zec et al in our article on the association between maternal occupational exposure to organic solvents (chlorinated, aromatic and Stoddard) and birth defects1 We reported a positive association between chlorinated solvents and neural tube defects, particularly spina bifida; we did not observe an association between solvent exposure and orofacial clefts. As
Data on CHD cases and control infants were obtained from the National Birth Defects Prevention Study for the period of 1997 to 2002. Exposure to PAHs was assigned by industrial hygienist consensus, based on self-reported maternal occupational histories from 1 month before conception through the third month of pregnancy. Logistic regression was used to evaluate the association between maternal occupational PAH exposure and specific CHD phenotypic subtypes among offspring ...
Is Maternal Exposure During Pregnancy a common side effect of Zoloft? View Maternal Exposure During Pregnancy Zoloft side effect risks. Male, weighting 1.10 lb, was diagnosed with psychotic disorder and took Zoloft 50 Mg, Daily. Patient was hospitalized.
Obesity is one of the leading threats to global public health. It is consequent to abnormal energy metabolism. Currently, it has been well established that maternal exposure to environmental stressors that cause inappropriate fetal development may have long-term adverse effects on offspring energy metabolism in an exposure timing-dependent manner, known as developmental programming of health and diseases paradigm. Rapidly increasing evidence has indicated that maternal exposure to ambient fine particles (PM2.5) correlates to abnormal fetal development. In the present study, we therefore assessed whether maternal exposure to diesel exhaust PM2.5 (DEP), the major component of ambient PM2.5 in urban areas, programs offspring energy metabolism, and further examined how the timing of exposure impacts this programming. The growth trajectory of offspring shows that although prenatal maternal exposure to DEP did not impact the birth weight of offspring, it significantly decreased offspring body weight from
Obesity is one of the leading threats to global public health. It is consequent to abnormal energy metabolism. Currently, it has been well established that maternal exposure to environmental stressors that cause inappropriate fetal development may have long-term adverse effects on offspring energy metabolism in an exposure timing-dependent manner, known as developmental programming of health and diseases paradigm. Rapidly increasing evidence has indicated that maternal exposure to ambient fine particles (PM2.5) correlates to abnormal fetal development. In the present study, we therefore assessed whether maternal exposure to diesel exhaust PM2.5 (DEP), the major component of ambient PM2.5 in urban areas, programs offspring energy metabolism, and further examined how the timing of exposure impacts this programming. The growth trajectory of offspring shows that although prenatal maternal exposure to DEP did not impact the birth weight of offspring, it significantly decreased offspring body weight from
Effects of maternal exposure to vehicle or indomethacin (0.8 mg/kg/day; e15.5-e18.5) on testis weight (A), and penis length (B) at Pnd25 and Pnd75 (adulthood)
New research shows that maternal exposure to a common and ubiquitous form of industrial pollution can harm the immune system of offspring and that this injury is passed along to subsequent generations, weakening the bodys defenses against infections such as the influenza virus.
JUSTIFICATIVA E OBJETIVOS: Vários estudos têm mostrado o peso ao nascer de ambos os pais como preditor do peso de nascimento do descendente, com correlação mais fortemente transmitida através da linhagem materna, sugerindo que exposições desfavoráveis à mãe desde a sua própria vida intrauterina até os períodos de pré-concepção e gestacional, além dos genes herdados, influenciam o tamanho ao nascimento da prole. A preocupação atual se relaciona ao ciclo intergeracional do baixo peso ao nascer ou do peso ao nascer elevado entre gerações, com todos os agravos imediatos e a longo prazo que estão implicados em nascer pequeno para a idade gestacional e/ou baixo peso ou grande para a idade gestacional e/ou macrossômico. O presente trabalho tem o objetivo de estudar a correlação entre o peso ao nascer da criança com o peso ao nascer da mãe, com as condições maternas, em crianças nascidas a termo no Hospital Universitário da USP (HU-USP). MÉTODOS: Foram identificados 773 ...
Decades of public health research have documented that smoking in pregnancy poses significant health risks to both mother and child. More recent studies have shown that even passive maternal exposure to secondhand smoke associates with negative birth outcomes. However, the mechanisms linking exposure to outcomes have remained obscure. As a first step toward defining the metabolic consequence of lo ...
Decades of public health research have documented that smoking in pregnancy poses significant health risks to both mother and child. More recent studies have shown that even passive maternal exposure to secondhand smoke associates with negative birth outcomes. However, the mechanisms linking exposure to outcomes have remained obscure. As a first step toward defining the metabolic consequence of lo ...
This study indicates that maternal occupational exposure to solvents may be associated with higher rates of ASD in their children. These results should be interpreted with caution given that this association did not remain significant after correcting the P-values for multiple comparisons. However, these results are consistent with earlier reports that have identified solvents as a potential risk factor for ASD.5 9 28 Research in the non-ASD population has found that solvents can be absorbed into the blood via skin or lungs.29 Water-soluble solvents may be cleared out of the body in urine or faeces, but many solvents are retained in organs including the brain. Solvents can also be metabolised into more toxic secondary substances (eg, methyl-butyl ketone, n-hexane) that are associated with a number of neurological effects and changes.29 In infants, solvents have been found to interfere with the glial guidance process which inhibits neuritic outgrowth.30 Infants of mothers who have been exposed to ...
PCBs are industrial chemicals that have neurotoxic effects, and studies indicate that they interfere with normal functions of the endocrine system. Although the manufacturing of PCBs was banned in the 1970s, they remain a major contaminant of the environment and of human tissues. Epidemiological studies show that exposure to PCBs during intrauterine development is highly associated with measurable neurological deficits in the offspring. In addition, deficits associated with PCBs are inversely associated with maternal thyroid hormone (TH) levels. This suggests that PCBs interfere with TH action in the fetal brain. Using in situ hybridization to measure HES-1 and HES-5 mRNA (direct markers of Notch activity), our laboratory has found that both maternal thyroid status and maternal exposure to PCBs influences Notch signaling in the fetal rat brain. We found that Aroclor 1254 produces a dose-dependent increase in HES-1 expression in the ventricular zone. Recent evidence suggests that Notch signaling ...
Andrea Baccarelli and colleagues show that maternal exposure to a dioxin following the industrial accident in Seveso, Italy in 1976 is associated with modified neonatal thyroid function even many years later.
Biology of Reproduction contains original scientific research on a broad range of topics in the field of reproductive biology, as well as minireviews.
I am so sorry things arent going well for your dreams for a second child. I just wanted to offer you a little hope, first of all, I have TWO friends who have the same clotting disorder, it must be very common! One of my best college friends had a son, then tried for her 2nd for several years and I think she miscarried at least 5 times or more. She did get pregnant again once they figured things out and she had to give herself shots almost her entire pregnancy, but she was able to keep the baby that time. So I think there are things that can be done?? You should check with your doctor about it if you havent already. Dont give up hope! ;) Ill be praying for you. Also- maybe you know but Kerigan didnt come easy for us, either. We have infertility (different issues, but still just as frustrating), and she took 2 years and several shots/treatments too. Why cant it just be easy?! Especially for good moms and dads who deserve another baby. It is so hard when it doesnt come easy for people like ...
PubMed journal article: Developmental toxicity study of pure trans-capsaicin in rats and rabbits. Download Prime PubMed App to iPhone, iPad, or Android
The study has elaborates the link between increased expressions of autistic-like behaviours in pre-school aged children to gestational exposure to selected environmental toxicants.
Due to an error during production, some data presented in Table 1 in the Experimental section of the published paper [1] were incorrect.[...]
The young age at onset of many cancers in childhood has led to investigations on maternal exposures during pregnancy. Data from a population-based case-control study in Germany (1992-1997) that included 1,867 cases and 2,057 controls was used to investigate this question. Maternal use of vitamin, fo …
5 throughout pregnancy of two.three vs. 1.seven, respectively). The ninety five% CIs were not notably larger In this particular analysis, suggesting that collinearity was not an important difficulty. Also, through pregnancy we discovered the Affiliation to become especially with the third-trimester exposure in products that involved exposure in all trimesters alongside one another. The specificity from the Affiliation for the prenatal period is in line with a number of other lines of proof that propose a prenatal origin of ASD, like data on variances in brain cytoarchitecture in brains of youngsters with ASD (McFadden and Minshew 2013; Stoner et al. 2014) and associations among maternal exposure to teratogens for the duration of pregnancy and ASD (Rodier 1995). Our effects also advise an association predominantly in boys, but this locating ought to be interpreted with warning, given the little number of ladies with ASD inside our sample ...
Maternal exposures to organochlorines prior to pregnancy are considered a risk to neonatal welfare, specifically in relation to neurocognitive functions. There is growing interest in the evaluation of maternal blood testing as a marker for fetal expo
DES placental exposure and temporal changes in gene expression. Analysis of gene expression profiles in rats offspring following DES maternal exposure.
In a study to estimate the relative risk of congenital malformations associated with maternal exposure to organic solvents such as white spirit, mothers of malformed babies were questioned about their contact Table 12-2 in the textbook by Aschengrau and Seageprovides a nice illustration of some of the limitations of p-values. When many possible associations are examined using a criterion of p< 0.05, the probability of finding at least one that meets the critical point increases in proportion to the number of A Scale Whose Smallest Divisions Are In Centimeters In a survey of breast cancer alternative diagnostic criteria were compared with the results of a reference test (biopsy). Outbreaks of disease Chapter 12. Video Summary: Confidence Intervals for Risk Ratio, Odds Ratio, and Rate Ratio (8:35) Link to a transcrip of the video The Importance of Precision With Non-Significant Results The difference between the Biased (systematic) subject variation -Blood pressure is much influenced by the ...
So this is making me feel like a FTM (first time mom) wll over again... even though I know its probably nothing I cant help but be a bit nervous. I havent had spotting this entire pregnancy. DH (dear husband) and I havent had sex recently (or, because of me, hardly ever this pregnancy) so I know its not that. Last night I wiped and noticed some pink/brown discharge. I have not been having cramping other than random BH yesterday during my normal walk in the afternoon. Thr only pain Ive had is RLP and pain in my vagina since shes been sitting so low this whole pregnancy. I have felt her move afterwards, not doing kick counts but it doesnt feel like more or less than normal) I called my OB last night and am waiting to get in for an appointment this morning at her request. Anyone else have the same thing? To be honest whats making me more worried is our LO (little one) PAPP-A result and that I oftrn have pain in my vagina due to babys position
This short sleeve cotton maternity tee is your new go-to essential. Its perfect for layering and wearing anytime and anywhere. Long enough to take you through your entire pregnancy.
Kris- TO answer your question, I am on metformin and synthroid. I had responded when you first posted back in Oct. Im so sorry about your m/c. I do split up my meds and I worked up to 2000mg a day. When I was on 1000 mg, I took one in the am and one in the pm. I did that for a week. THen upped the dose to 1500. I took 2 in the am and 1 at night. Now Im on 2000mg. I have stayed on that through my entire pregnancy. So far my baby is measuring perfect. The thing with metformin is that if you continue to eat crap that upsets your stomach it will tear you up. You have to change how you eat so that it does not bother you ...
AMHERST, Mass. - Some studies indicate that early life exposure to pollutants such as PCBs and phthalates can predispose people to disease. Now environmental scientist Alicia Timme-Laragy at the University of Massachusetts Amherst has received a five-year, $1.7 million grant from the National Institute of Environmental Health Sciences for a multi-level study of early life exposure to environmental contaminants and aberrant pancreas development, which may predispose one to diabetes.. Disease may result from environmental contaminant exposure in early life via oxidative stress, disrupted signaling pathways controlling embryo growth, or via subtle structural or functional changes to insulin-producing pancreatic beta cells, she notes. Results of this work will be relevant to public health officials concerned about such exposures as well as molecular biologists studying signaling pathways to gain a mechanistic understanding of disease processes very early in life.. The researchers will study toxic ...
Public release date: 15-May-2008 ORLANDO, FL, MAY 18, 2008-Higher incidences of congenital anomalies, including cryptorchidism (undescended testicles) and hypos
Maternal exposure to higher levels of air pollution is associated with lower IQ scores in their children. For those whose mothers were in the highest 10% of exposure had IQ score that were, on average, 2.5 points lower than those whose mothers were in the lowest 10%. However, higher maternal folate levels appear to neurtralize the effect of high pollution exposure on offspring. Read More ...
A new study of delivery outcome following maternal use of SSRI antidepressants in earlypregnancy has been conducted utilizing the Swedish national registry data. Previouspublished studies utilizing these registry data, and cited in the previous version of theparoxetine Prescribing Information, found no evidence for an increased overall risk ofmajor malformations with maternal exposure to SSRI medications, including paroxetine(Hallberg 2005, Ericson 1999). In this latest study, the population that was investigatedcomprised infants of 6,896 women exposed to antidepressants in early pregnancy(including 5,175 infants born to 5,123 women reporting the use of any SSRI in the firsttrimester). Among them, 815 women reported the use of paroxetine and they delivered822 infants. Rates of malformations in these infants were compared with the generalpopulation experience. No increase in the overall rate of congenital malformations wasobserved in infants exposed to paroxetine (4.9%), compared with the general ...
Is anyone juicing during their pregnancy? I am 5 weeks pregnant & have been juicing fruits & veggies! I did it before I was pregnant & am containing it during my entire pregnancy. I have noticed a ris...
Prenatal Exposure Delayed Effects: The consequences of exposing the FETUS in utero to certain factors, such as NUTRITION PHYSIOLOGICAL PHENOMENA; PHYSIOLOGICAL STRESS; DRUGS; RADIATION; and other physical or chemical factors. These consequences are observed later in the offspring after BIRTH.
We did not find out what we were having, but we were quite convinced we were having a boy. We had our girl name picked out for basically my entire pregnancy. We decided on our boy name about 2 weeks before my due date and we still werent totally sold on it. She came out a girl, though, so it all worked out! We wanted a biblical name that wasnt weird for the first name and family name for the middle name. My hubby listens to this radio show called Garage Logic and they talk about foghornable names which are weird names, so we couldnt go with anything weird. I also have a pet peeve about common names that are spelled in weird ways, so that was out. Picking a name is really hard! I still dont really like the boy name we had, so whenever #2 comes along i have no idea what we would name him or her!. ReplyDelete ...
Hey all! Long time since Ive been here. I just weaned my 2nd child in January 2012 after 2 years of BF..and had my 3rd child December 7. Ive been exclusively breastfeeding since birth. I pumped some with my 2nd child but dont remember the rules of when or how to pump an occasional bottle. I have a history of a Pulmonary Embolism/Blood Clot that required me to take Heparin injections the entire pregnancy. I must go to the follow up appt around the 5-6 week mark postpartum. The appt is
I had the best 2 hour nap of my life. I seriously hadnt slept this well my entire pregnancy, and I remembered thinking to myself, I hope the nurse doesnt wake me up; I could sleep for another 3 days like this -- maybe we can deliver the baby in three days? It was around 10am at this point, and I told King that Id probably be ready to push around noon (I was 7-8 cm dilated, but babys head was still far up). King thought it would be closer to 3-4pm. The nurse woke me up around 1pm and checked and saw that the baby had descended, and I was fully dilated. So we did our first practice push. At the end of the push, she said to King (who was holding one leg while the nurse had the other leg) See that black part? Thats the top of the babys head. I was really encouraged, I figured, it cant be that far if they can already see the top of the babys head. We did a few more pushes, and I was gaging how it was going based on King & the nurses reactions and expressions. King said to me in Hindi at ...
Once she gets to Childrens, they will do an ultrasound on her to check to make sure all the other internal organs look fine. They will also repeat the fetal echocardiogram to ensure that her heart is strong enough for surgery. She explained that a lot of kids with this issue also have other organ issues, so if they are going to go in and do a repair they want to know ahead of time of any other issues so they can fix them all. An example was to make sure there wasnt any blockage in the esophageal/tracheal region, proper kidney functioning, etc. She said that most of these issues would have already shown themselves on a previous ultrasound, but they will double-check. She also said that sometimes these kids have an extra vertebra or shortened limbs. Im not too considered about the limbs considering this kids limbs have been measuring 2-3 weeks ahead for the entire pregnancy. ...
The level and duration of exposure to nerve gas determines the severity of resulting symptoms and effects. In low amounts, with a short duration of ex
Dr Hure focus is giving children in Australia and around the world the best start to life through optimal nutrition and early life exposures.
TY - JOUR. T1 - Risk of hypospadias in relation to maternal occupational exposure to potential endocrine disrupting chemicals. AU - Vrijheid, M. AU - Armstrong, B. AU - Dolk, Helen. AU - van Tongeren, M. AU - Botting, B. PY - 2003. Y1 - 2003. U2 - 10.1136/oem.60.8.543. DO - 10.1136/oem.60.8.543. M3 - Article. VL - 60. SP - 543. EP - 550. JO - Occupational and Environmental Medicine. JF - Occupational and Environmental Medicine. SN - 1351-0711. IS - 8. ER - ...
Results Multivariable analysis showed a strong association with potential maternal occupational exposure to heavy metals with an over twofold increased risk of hypospadias (OR 2.6; 95% CI 1.3 to 5.2), and women exposed to phthalates were more likely to have an affected son (OR 1.2; 95% CI 0.8 to 1.7). Compared with mild or isolated cases, the risks of moderate-severe hypospadias or multiple defects were increased up to two- and fivefold, respectively, with maternal exposure to most types of EDCs. Paternal occupational exposures to polychlorinated organic (OR 1.3; 95% CI 1.0 to 1.8) and bi-phenolic (OR 1.6; 95% CI 1.0 to 2.6) compounds were also possible risk factors. ...
Mounting evidence has shown an increased risk of gestational diabetes mellitus (GDM) in association with elevated exposure to air pollution. However, limited evidence is available concerning the effect of specific air pollutant(s) on GDM incidence. We conducted this case-control study on 6717 mothers with GDM diagnosed in 2006-2013 and 6717 age- and year of delivery-matched controls to further address the risk of GDM in relation to specific air pollutant. Both cases and controls were selected from a cohort of 1-million beneficiaries of Taiwans National Health Insurance program registered in 2005. Maternal exposures to mean daily air pollutant concentration, derived from 76 fixed air quality monitoring stations within the 12-week period prior to pregnancy and during the 1st and 2nd trimesters, were assessed by the spatial analyst method (i.e., ordinary kriging) with the ArcGIS software. After controlling for potential confounders and other air pollutants, an increase in pre-pregnancy exposure of 1 inter
The persistence of racial disparities in low birth weight (LBW) and preterm birth (PTB) is one of the most widely documented problems in public health. Most studies of these birth outcomes have focused primarily on maternal exposure to individual-level risk factors during the prenatal period. That research has resulted in only a partial explanation for the observed disparities. My research, therefore, had two primary aims: (1) to examine the relationship between adverse birth outcomes and maternal exposure to family and neighborhood disadvantage during childhood; and (2) to determine the behavioral, psychosocial, and health pathways through which these exposures affect birth outcomes and translate into racial disparities. Data for this research came from Waves I and III of the National Longitudinal Study of Adolescent Health (Add Health). The sample consisted of 500 Black and 1,077 White females who gave birth in late adolescence or young adulthood. I used structural equation modeling to test ...
A study of published work was carried out in a search for evidence of a causal role for parental occupational exposure in the origin of structural and functional defects of the central nervous system (CNS) in children. Studies that consider this topic are scarce and mostly refer to broad categories of exposures and effects. Non-occupational studies referring to environmental exposure of humans and studies on experimental animals were also reviewed. The studies on animals provided straightforward evidence about morphological and behavioural abnormalities resulting from some agents used occupationally. The studies on humans yielded a scala of defects that could be ascribed to exposure to high doses of various agents in the environment. Evidence for a causal role of occupational exposure has not been found, but a highly probable influence on the developing CNS is hypothesised for lead, methyl mercury, and ionising radiation. Parental occupational exposure to cadmium, organic solvents, anaesthetics, ...
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John:. I and other community members are still concerned about chemical exposures to all Kipp factory workers, especially women who are or could become pregnant.. As far as VOCs and exposures via vapor intrusion, TCE is of particular concern because it is more toxic than PCE-it is a carcinogen and also causes neurological, immune system, kidney, liver, reproductive, and developmental effects. Many of the effects from fetal exposures may not show up until adulthood. Vapor intrusion screening levels for TCE are much lower than for PCE-see here.** Also, recently government risk assessors concluded that the weight of evidence indicates that TCE and/or its metabolites could cause cardiac defects in fetuses even if maternal exposure durations are short, one-time, and relatively low dose. Below my name, I pasted a summary from an EPA TCE risk assessment document re TCE and heart defects. You can find the IRIS info on TCE toxicity here and here.. We know Kipp used TCE as well as PCE at least into the ...
1 Jamal, A., Agaku, I. T., OConnor, E., King, B. A., Kenemer, J. B., & Neff, L. (2014). Current cigarette smoking among adults-United States, 2005-2013. MMWR Morb Mortal Wkly Rep, 63(47), 1108-1112.. 2 Centers for Disease Control and Prevention. (2016). Current Cigarette Smoking Among Adults in the United States.. 3 Pineles, B. L., Park, E., & Samet, J. M. (2014). Systematic review and meta-analysis of miscarriage and maternal exposure to tobacco smoke during pregnancy. American journal of epidemiology, 179(7), 807-823.. 4 Centers for Disease and Control. (2015). Highlights: Impact on Unborn Babies, Infants, Children, and Adolescents.. 5 Cnattingius, S. (2004). The epidemiology of smoking during pregnancy: smoking prevalence, maternal characteristics, and pregnancy outcomes.Nicotine & Tobacco Research, 6(Suppl 2), S125-S140.. 6 Centers for Disease Control and Prevention (2016). How Does Smoking During Pregnancy Harm My Health and My Baby?. 7 American College of Obstetricians and Gynecologists. ...
While increasing evidence suggests that maternal exposure to high levels of ambient air pollutants during pregnancy plays a critical role in producing adverse p...
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You said something that, to be honest, really chilled us.You said you would be there for us should we (Kim specifically) ever require an abortion. We loved all five of our children well before they were born, throughout our entire pregnancies. Birth didnt change them genetically or inherently, it simply brought them into our full view. You might have extended us an offer to euthanize our toddlers should they become too much of a burden financially, physically or psychologically, and our reaction would have been exactly the same. To one who loves her child from conception onward, there is no distinction. So your offer was lost on us, as we would never deny our own children, whether they sleep safely in our womb or in a crib. You may believe that every woman would submit to an abortion if the circumstances were right, but you would be wrong. And how much more loving and civilized it would have been had you offered to help us with an adoption instead. There are families waiting to adopt every ...
You said something that, to be honest, really chilled us.You said you would be there for us should we (Kim specifically) ever require an abortion. We loved all five of our children well before they were born, throughout our entire pregnancies. Birth didnt change them genetically or inherently, it simply brought them into our full view. You might have extended us an offer to euthanize our toddlers should they become too much of a burden financially, physically or psychologically, and our reaction would have been exactly the same. To one who loves her child from conception onward, there is no distinction. So your offer was lost on us, as we would never deny our own children, whether they sleep safely in our womb or in a crib. You may believe that every woman would submit to an abortion if the circumstances were right, but you would be wrong. And how much more loving and civilized it would have been had you offered to help us with an adoption instead. There are families waiting to adopt every ...
Being in the hospital this past week has really forced me to acknowledge the fact that these babies have to come out and not by a wave of a magic wand. This is the part that i have been dreading the most. This entire pregnancy I tried not focusing on the delivery and just on the joy of having my babies in my arms and being a mom. Well now all I think about are these contractions and the big delivery. Honestly its all very daunting to me. I havent committed to a c-section or a vaginal delivery. I get mixed opinions on both and its a lot to consider. With a cesarean I worry about the recovery, the pain of nursing two babies and an incision, not to mention a scar. With vaginally I worry about putting my babies in distress or going through all of the labor and then needing an emergency cesarean anyway. I also worry that if the babies are in position for me to deliver naturally and I choose cesarean then I will regret not trying. My doctor is great, he said that if the babies heart rates look ...
Being in the hospital this past week has really forced me to acknowledge the fact that these babies have to come out and not by a wave of a magic wand. This is the part that i have been dreading the most. This entire pregnancy I tried not focusing on the delivery and just on the joy of having my babies in my arms and being a mom. Well now all I think about are these contractions and the big delivery. Honestly its all very daunting to me. I havent committed to a c-section or a vaginal delivery. I get mixed opinions on both and its a lot to consider. With a cesarean I worry about the recovery, the pain of nursing two babies and an incision, not to mention a scar. With vaginally I worry about putting my babies in distress or going through all of the labor and then needing an emergency cesarean anyway. I also worry that if the babies are in position for me to deliver naturally and I choose cesarean then I will regret not trying. My doctor is great, he said that if the babies heart rates look ...
RISK AND REALITY: THE IMPLICATIONS OF PRENATAL EXPOSURE TO ALCOHOL AND OTHER DRUGS By Joanne P. Brady, Marc Posner, Cynthia Lang and Michael J. Rosati The Education Development Center, Inc. 1994.
Hey everyone... So, I went to the doc yesterday. They were really nice and she listened to everything from the very beginning. She said that it could still possibly be hemrroids (I dont believe that one), but she said since the prednisone did improve my symptoms that its indictive of inflammation. They really dont want to do a colonoscopy until after I deliver, so they are going to start me on cesena (spelling???) Its a suppository.... Im really nervous, but she said it comes with directions and everything. So my pharmacy ordered it, and it should get here by Friday. She also wants me to ween off the prednisone in the next two weeks, which Im super glad for cuz I wasnt comfortable being on it anyway. She said if the cesena works theyll keep me on that for the entire pregnancy and then do the colonoscopy. If it doesnt work, theyll do a flexiscope, I think she said, in the doctors office. She said it could be Crohns with my family history, but they arent entirely sure. So, they are ...
The other night my honey and I were watching a medical documentary-type show. On it was a young married couple who already had their fair share of hills to climb.. the husband was fighting overseas and the young wife was pregnant. She had been without her husband throughout her entire pregnancy, and their unborn baby…
Sigma-Aldrich offers abstracts and full-text articles by [Ronit Avitsur, Sigal Levy, Rachel Grinshpahet, Naama Goren, Ofer Hirsh, Assaf Zalko].
Other environmental factors that have been studied include seasonal causes (such as pesticide exposure); maternal diet and ... Other contributing factors may include maternal nutritional deficiencies, exposure in utero to viral infections, trauma, drugs ... Cleft lip and other congenital abnormalities have also been linked to maternal hypoxia caused by maternal smoking, with the ... Maternal alcohol use has also been linked to cleft lip and palate due to the effects on the cranial neural crest cells. The ...
Vaktskjold, A; Talykova, L. V; Chashchin, V. P; Odland, J. O; Nieboer, E (2008). "Maternal nickel exposure and congenital ... A less-common form of chronic exposure is through hemodialysis as traces of nickel ions may be absorbed into the plasma from ... The major source of nickel exposure is oral consumption, as nickel is essential to plants. Nickel is found naturally in both ... The human and animal data consistently indicate a lack of carcinogenicity via the oral route of exposure and limit the ...
Vaktskjold, A.; Talykova, L. V.; Chashchin, V. P.; Odland, J. O.; Nieboer, E. (2008). "Maternal nickel exposure and congenital ... The human and animal data consistently indicate a lack of carcinogenicity via the oral route of exposure and limit the ... "Preventable Exposures Associated With Human Cancers". J Natl Cancer Inst 103: 1827-1839. Vaktskjold, A.; Talykova, L. V.; ...
Other contributing factors may include maternal nutritional deficiencies, exposure in utero to viral infections, trauma, drugs ... Cleft lip and other congenital abnormalities have also been linked to maternal hypoxia caused by maternal smoking,[49] with the ... such as pesticide exposure); maternal diet and vitamin intake; retinoids (members of the vitamin A family); anticonvulsant ... Maternal alcohol use has also been linked to cleft lip and palate due to the effects on the cranial neural crest cells. The ...
... exposure to toxins such as methylmercury; and even exposure to maternal psycho-social stress. Trauma in utero increases the ... or exposure to medicines used to relieve maternal pain or induce labor. These experiences can cause both physical and ... Kinsella MT, Monk C (September 2009). "Impact of maternal stress, depression and anxiety on fetal neurobehavioral development ... Trauma experienced in utero includes maternal smoking, alcohol or drug use during pregnancy; ...
At least one of its programs, the Maternal Infant Health Outreach Worker (MIHOW) Program, was moved to the Vanderbilt School of ... McDonald, Kevin (1978). "Outrage and Outreach: The Student Health Coalition". Southern Exposure. 6 (2): 19-23. "Campus Life: ... "MIHOW's History". Maternal Infant Health Outreach Worker. Vanderbilt University. Retrieved August 24, 2017. Williams, John; ... maternal and infant care programs. Two Vanderbilt law students started the East Tennessee Research Corporation (ETRC), which ...
"Maternal HIV Testing and Identification of Perinatal HIV Exposure , Perinatal , ClinicalInfo". clinicalinfo.hiv.gov. Retrieved ... "Maternal HIV Testing and Identification of Perinatal HIV Exposure , Perinatal , ClinicalInfo". clinicalinfo.hiv.gov. Retrieved ... to slow maternal disease progression, and to reduce the risks of maternal opportunistic infection and death. It is important to ... If the maternal viral load is high (HIV RNA greater than 1000 copies/mL) or if her HIV viral load is unknown around the time of ...
bAssuming transplacental infections 10-14 days after maternal exposure. The effect, if any, of PPV on the ovum before ovulation ... Transplacental infection also follows maternal exposure after midgestation, but fetuses usually survive without obvious ... to identify infected cells in maternal and fetal tissues at progressively longer intervals after maternal oronasal exposure. ... This interval of maternal susceptibility is indicated by the collective results of several experimental studies, by in-depth ...
These deficits were linked to maternal exposure to perchlorate. Subsequently, the National Academy of Science (NAS) reviewed ... Reference doses are specific to dietary exposure. When assessing inhalation exposure, EPA uses "reference concentrations" (RfCs ... According to the EPA, "[a]n aggregate daily exposure to a [chemical] at or below the RfD (expressed as 100 percent or less of ... The EPA then looked at dietary exposure to endosulfan, and found that for the most exposed 0.1% of children age 1-6, their ...
The most common causes of maternal mortality are maternal bleeding, maternal sepsis and other infections, hypertensive diseases ... Exposure to environmental toxins in pregnancy. *Exposure to recreational drugs in pregnancy *Ethanol during pregnancy can cause ... "Severe Maternal Morbidity in Canda" (PDF). The Society of Obstetricians and Gynaecologists of Canada (SOGC). Archived (PDF) ... "Maternal and Child Health Journal. 14 (4): 519-27. doi:10.1007/s10995-009-0491-0. PMC 2895902. PMID 19565330.. ...
Factors that precipitate include genetics, and maternal exposure to teratogens. Genetic causes of müllerian duct anomalies are ... In utero DES exposure has additionally been linked to epigenetic changes responsible for uterine anomalies such as ... A dose-response association for DES has not been establish but an association with the time of exposure in utero suggest ... Exposure to DES induced multiple uterine abnormalities including constriction bands, hypoplasticity in the uterine cavity and ...
... may result at high levels of maternal CO exposure, however the exact amount of exposure of CO to become a fetal threat is ... Fetal growth and maternal exposure to particulate matter during pregnancy. Environmental Health Perspectives, 107(6), 475-480 ... Exposure to vehicle air pollutants has been noted as primary cause for infant mortality and morbidity, and is also argued to be ... High exposure to nitrogen dioxide may cause fetal mutations, damage a developing fetus, and decrease a woman's ability to ...
... the timing of maternal exposure to the virus may play a greater role as compared to overall exposure. Environment Several ... The inconsistent findings among the literature may be accounted for by the timing of maternal exposure to HSV-2. Animal models ... Buka SL, Cannon TD, Torrey EF, Yolken RH (April 2008). "Maternal exposure to herpes simplex virus and risk of psychosis among ... Similarly, research surveying maternal exposure to Herpes Type 2 demonstrates contrasting outcomes. According to antibody ...
June 2007). Prenatal Exposure to Maternal Depression and Cortisol Influences Infant Temperament. Journal of the American ... Adverse experiences during development (e.g. prenatal exposure to maternal stress, poor attachment histories, sexual abuse) are ... A chronic stressor involves exposure to a long-term stressor, and a distant stressor is a stressor that is not immediate. ... O'Connor; Heron; Golding; Beveridge; Glover (2002). "Maternal antenatal anxiety and children's behavioural/emotional problems ...
Toxins include fetal exposure to lead, mercury, and ethanol or hazardous environments. Prenatal exposure to mercury may lead to ... Maternal drug use occurs when drugs ingested by the pregnant woman are metabolized in the placenta and then transmitted to the ... Exposure to secondhand smoke leads to higher risks of low birth weight and childhood cancer. If a mother is infected with a ... Exposure to high levels of lead prenatally is related to prematurity, low birth weight, brain damage, and a variety of physical ...
Metrecia L. Terrella; Kathleen P. Hartnetta; Hyeyeun Limb; Julie Wirthc & Michele Marcu (January 2015). "Maternal exposure to ... These include three exposure groups - all people who lived on the quarantined farms, people who received food from these farms ... There is evidence that pre- and post-natal exposure to PBB in girls leads to menarche at an earlier age. Early studies on the ... Exposure to the coplanar stereoisomer 3,3',4,4',5,5'-hexabromobiphenyl (but not the non-coplanar stereoisomer) in genetically ...
Parental opiate exposure has greater conflicting impact than parental cocaine exposure on the infant's Central Nervous System ... Malnutrition, maternal depression and maternal substance abuse are three of these factors which have received particular ... "Maternal Employment and Child Cognitive Outcomes in the First Three Years of Life: The NICHD Study of Early Child Care." Child ... Parental marijuana exposure may have long-term emotional and behavioral consequences. A ten-year-old child who had been exposed ...
More early exposure programs targeted to underrepresented groups in high school would help, since early exposure has been ... Maternal mortality rates are 4.5 times higher for American Indian and Alaska Native women than they are for non-Hispanic white ... For maternal mortality, Black women who are college graduates have pregnancy-related mortality ratios (number of pregnancy- ... Similarly, Asian Americans had a maternal mortality rate that was lower than that of non-Hispanic whites as well as the ...
Cain, Mary A.; Bornick, Patricia; Whiteman, Valerie (2013-03-01). "The maternal, fetal, and neonatal effects of cocaine ... exposure in pregnancy". Clinical Obstetrics and Gynecology. 56 (1): 124-132. doi:10.1097/GRF.0b013e31827ae167. ISSN 1532-5520. ...
Environmental factors refer for example to maternal smoking and the maternal exposure to amine-containing drugs. Several ... Gardner JS, Guyard-Boileau B, Alderman BW, Fernbach SK, Greene C, Mangione EJ (February 1998). "Maternal exposure to ... Carmichael SL, Ma C, Rasmussen SA, Honein MA, Lammer EJ, Shaw GM (February 2008). "Craniosynostosis and maternal smoking". ... 3.0.CO;2-7 "Further evidence for an association between maternal smoking and craniosynostosis". Teratology. 62 (3): 145-6. doi: ...
DNA methylation is determined in utero by maternal nutrition and environmental exposure. Methyl is synthesized de novo but ... which is determined by maternal diet and environmental exposure. As agouti itself inhibits melanocortin receptors responsible ... Ensuring maternal diets are high in methyl equivalents is a key preventive measure for reducing ectopic expression of agouti in ... Cooney CA, Dave AA, Wolff GL (August 2002). "Maternal methyl supplements in mice affect epigenetic variation and DNA ...
A 2008 study evaluated whether maternal exposure is associated with modified neonatal thyroid function in the highly exposed ... "Neonatal Thyroid Function in Seveso 25 Years after Maternal Exposure to Dioxin". PLOS Medicine. 5 (7): e161. doi:10.1371/ ... Moreover, although several exposures of populations to dioxins had occurred before, mostly in industrial accidents, they were ... This result of the underlying Seveso study has been noted to provide the most pronounced evidence for prenatal exposure to an ...
... refers to congenital maldevelopments that are linked to maternal diabetes. Prenatal exposure to ... In maternal diabetes, 90% of pregnancy losses happen in the first trimester due to oxidative stress. Diabetic embryopathy ... Rankin, J.; Tennant, P. W. G.; Stothard, K. J.; Bythell, M.; Summerbell, C. D.; Bell, R. (2010). "Maternal body mass index and ... It is also inversely related to the gestational age at first exposure. The comorbidities associated with pregestational type 2 ...
... can also occur due to maternal exposure to teratogens during pregnancy. The exact cause of congenital ...
Jourdain G, Ngo-Giang-Huong N, Le Coeur S (Jul 2004). "Intrapartum exposure to nevirapine and subsequent maternal responses to ... It may be used to prevent mother to child spread during birth but is not recommended following other exposures. It is taken by ... A short course of maternal zidovudine/lamivudine is recommended by the U.S. Public Health Service Task Force to reduce this ... Recommendations for use of antiretroviral drugs in pregnant HIV-1-infected women for maternal health and interventions to ...
The reproductive anatomy of offspring can particularly be affected if maternal exposure occurs. In females, this includes ... In wildlife, exposure to EDCs can result in altered fertility, reduced viability of offspring, impaired hormone secretion or ... Exposure of fish to EDCs has also been associated with abnormal thyroid function, decreased fertility, decreased hatching ... The effects of carcinogens are most often related to human exposures but mammals are not the only species that can be affected ...
These include maternal infection and certain chemical and medical exposures." She has also said that early intervention "can ...
If exposure is suspected, the person should be removed from the source of exposure and decontaminated. Treatment involves ... 2009). "Fetal and maternal lesions of cyanide dosing to pregnant goats". Small Ruminant Research. 87 (1-3): 76-80. doi:10.1016/ ... may reduce the negative effects of chronic exposure, and a deficiency can lead to negative health effects following exposure.[ ... such as cyanide-containing smoke exposure, suggests significant cyanide exposure. Methods of detection include colorimetric ...
Environmental factors refer for example to maternal smoking and the maternal exposure to amine-containing drugs. Several ... "Maternal exposure to prescription and non-prescription pharmaceuticals or drugs of abuse and risk of craniosynostosis". ... Källén K (September 1999). "Maternal smoking and craniosynostosis". Teratology. 60 (3): 146-50. doi:10.1002/(SICI)1096-9926( ... Carmichael SL, Ma C, Rasmussen SA, Honein MA, Lammer EJ, Shaw GM (February 2008). "Craniosynostosis and maternal smoking". ...
The data examining the association between maternal topical retinoid exposure in the first trimester of pregnancy and adverse ... Approximately 160 babies were born with birth defects due to maternal use of isotretinoin during pregnancy.[186][187] ... and neither cleanliness nor exposure to sunlight appears to play a part.[2][13][14] In both sexes, hormones called androgens ... Even minimal skin exposure to the sun's ultraviolet rays can sustain hyperpigmentation.[35] Daily use of SPF 15 or higher ...
Occupational exposure[edit]. Outdoor workers are at risk of Lyme disease if they work at sites with infected ticks. This ... "Maternal Lyme borreliosis and pregnancy outcome". International Journal of Infectious Diseases. 14 (6): e494-8. doi:10.1016/j. ... Exposure to the Borrelia bacterium during Lyme disease possibly causes a long-lived and damaging inflammatory response,[96] a ... Further information: Weather and climate effects on Lyme disease exposure. Transmission[edit]. Lyme disease is classified as a ...
This improves the contrast resolution of the image, but also increases radiation exposure for the patient.[16] ... and dosimeters used to measure the local radiation exposure, dose, and/or dose rate, for example, for verifying that radiation ...
In these cases, the disorder is typically inherited from the maternal parent. Because RPS6KA3 is located on the X chromosome, ... Because sudden excitement or fright can trigger a SIDA episode it is important to minimize exposure to startling stimuli. ...
Inhalation of tiny particles of infectious material (aerosol) is believed to be the most significant means of exposure. It is ... "A prospective study of maternal and fetal outcome in acute Lassa fever infection during pregnancy". BMJ. 297 (6648): 584-7. ... Infection typically occurs by direct or indirect exposure to animal excrement through the respiratory or gastrointestinal ... it will excrete the virus throughout the rest of its lifetime through feces and urine creating ample opportunity for exposure.[ ...
In her role as global patron of The White Ribbon Alliance for Safe Motherhood, and chair of the Maternal Mortality Campaign, ... implementation of the Minamata Convention to protect human health and the environment from effects of exposure to mercury and ... "World Health Assembly approves monitoring framework for maternal and child nutrition". Geneva: World Health Organization. 21 ... maternal and child health]" in an echo of Allan Rosenfield's landmark Lancet article of 1985 - and highlighting that the ...
Studies have shown that by combining live music, such as harp music, with the Kangaroo Care, maternal anxiety is reduced. This ... the potential for harm from exposure to particular agents, the accuracy of diagnostic tests, and the predictive power of ... "Safe sound exposure in the fetus and preterm infant". Journal of Obstetric, Gynecologic, and Neonatal Nursing. 41 (2): 166-70 ... therapy may be a useful therapeutic tool to reduce symptoms and improve functioning among individuals with trauma exposure and ...
... maternal medial prefrontal cortical activity in response to child separation among mothers with histories of violence exposure ... Nurturant maternal care, in turn, may enhance HPA functioning in at least two ways. First, maternal care is crucial in ... Thus, if a developing child (i.e., fetus to neonate) is exposed to ongoing maternal stress and low levels of maternal care (i.e ... maternal stress, and postnatal - i.e. maternal care), and later-life environment (which determines match/mismatch, as well as a ...
... this exposure is a significant occupational hazard for health care professionals.[16] Exposure to dangerous chemicals, ... Maternal and newborn health practitioners[edit]. Main articles: Obstetrics, Midwifery, and Birth attendant ... "Exposure to Stress: Occupational Hazards in Hospitals". NIOSH Publication No. 2008-136 (July 2008). 2 December 2008. doi: ... Exposure to respiratory infectious diseases like tuberculosis (caused by Mycobacterium tuberculosis) and influenza can be ...
Offspring remain in the mound for 1-6 more months in the maternal caches.[14] ... In addition, maximizing time in their burrows minimizes their exposure to predators.[10] ...
Problems during pregnancy may include preeclampsia, maternal diabetes with vascular disease, congenital fetal infections, drug/ ... Space exposure. *Ulegyria. ReferencesEdit. *^ Malhotra R, et al. (Nov 2001). "Hypoxia induces apoptosis via two independent ...
Exposure to tellurium compounds produces a garlic-like odour on the breath, caused by the formation of ethyl telluride.[13] ... Perez-D'Gregorio RE, Miller RK, Baggs RB (1988). "Maternal toxicity and teratogenicity of tellurium dioxide in the Wistar rat: ...
As pups, young rats use different types of ultrasonic cries to elicit and direct maternal search behavior,[18] as well as to ... "Developmental expression of defensive responses during exposure to conspecific adults in preweanling rats (Rattus norvegicus)" ... Grota, L. J.; Ader, R. (1969). "Continuous recording of maternal behavior in Rattus norvegicus". Animal Behaviour. 17 (4): 722- ... When lactating, female rats display a 24-hour rhythm of maternal behavior, and will usually spend more time attending to ...
Acute exposure to toxic levels of benzene may cause euphoria, anxiety, and irritability lasting up to 2 weeks after the ... "BDNF Methylation and Maternal Brain Activity in a Violence-Related Sample". PLoS ONE. 10 (12): e0143427. Bibcode:2015PLoSO.. ... exposure.[79]. PsychologicalEdit. Poor coping skills (e.g., rigidity/inflexible problem solving, denial, avoidance, impulsivity ...
Zimmerberg B, Mickus LA (1990). "Sex differences in corpus callosum: Influence of prenatal alcohol exposure and maternal ... Fetal Alcohol Exposure. April 2015 [10 June 2015].. *^ 6.0 6.1 McHugh, RK; Wigderson, S; Greenfield, SF. Epidemiology of ... 42.0 42.1 42.2 Mattson, S.N., & Riley, E.P. (2002). "Neurobehavioral and Neuroanatomical Effects of Heavy Prenatal Exposure to ... Sullivan, W.C. (1899). A note on the influence of maternal inebriety on the offspring. Journal of Mental Science, 45, 489-503. ...
"Maternal Smoking during Pregnancy and Childhood Obesity". Retrieved 6 November 2016. March, Penny D., and Carita Caple. " ... Preventing Smoking and Exposure to Secondhand Smoke Before, During, and After Pregnancy. MedlinePlus Encyclopedia Placenta ... There can also be complications, such as maternal hemorrhage. Some studies show that the probability of premature birth is ... A recent study has proposed that maternal smoking during pregnancy can lead to future teenage obesity. While no significant ...
79,0 79,1 79,2 79,3 «The role of allergen exposure and avoidance in asthma»։ Adolesc Med State Art Rev 21 (1): 57-71, viii-ix։ ... van de Loo KF, van Gelder MM, Roukema J, Roeleveld N, Merkus PJ, Verhaak CM (January 2016)։ «Prenatal maternal psychological ... Bornehag CG, Nanberg, E (April 2010)։ «Phthalate exposure and asthma in children»։ International journal of andrology 33 (2): ... Lodge CJ, Allen, KJ, Lowe, AJ, Hill, DJ, Hosking, CS, Abramson, MJ, Dharmage, SC (2012)։ «Perinatal cat and dog exposure and ...
Second exposure to allergen. 1 - antigen; 2 - IgE antibody; 3 - FcεRI receptor; 4 - preformed mediators (histamine, proteases, ... Does maternal diet during pregnancy and lactation affect outcomes in offspring? A systematic review of food-based approaches»։ ... Marra F, Lynd L, Coombes M, Richardson K, Legal M, Fitzgerald JM, Marra CA (March 2006). "Does antibiotic exposure during ... Effects of early nutritional interventions on the development of atopic disease in infants and children: the role of maternal ...
Several genes and environmental factors (e.g. pesticide exposure) may play a role in onset of PD. Hallmarks include mutations ...
Early exposure to potential allergens[2][3]. Treatment. Avoiding the food in question, having a plan if exposure occurs, ... From two reviews, maternal intake of omega-3, long-chain fatty acids during pregnancy appeared to reduce the risks of medically ... Early exposure to potential allergens may be protective.[2] Specifically, early exposure to eggs and peanuts reduces the risk ... Inhalation exposure[edit]. Allergic reactions to airborne particles or vapors of known food allergens have been reported as an ...
... and maternal and infant health, and supplements the information obtained on birth certificates collected through the National ... and environmental exposures. ... Maternal and Child Health Bureau and elsewhere. NCHS's National ...
Parental nutrition, in utero exposure to stress, male-induced maternal effects such as attraction of differential mate quality ... In the Överkalix study, paternal (but not maternal) grandsons[129] of Swedish men who were exposed during preadolescence to ... A person's paternal grandson is the son of a son of that person; a maternal grandson is the son of a daughter. ... Cooney CA, Dave AA, Wolff GL (August 2002). "Maternal methyl supplements in mice affect epigenetic variation and DNA ...
"Skin Exposure & Effects". NIOSH Topics. National Institute for Occupational Safety and Health. Retrieved 7 August 2012.. ... Applications of the public health system include the areas of maternal and child health, health services administration, ...
Hallman, M (Apr 2012). "Premature birth and diseases in premature infants: common genetic background?". The Journal of Maternal ... exposure to methylmercury during pregnancy, a difficult delivery, and head trauma during the first few years of life, among ... The Journal of Maternal-Fetal & Neonatal Medicine. 25 Suppl 1: 12-6. doi:10.3109/14767058.2012.663161. PMID 22309119.. ... The Journal of Maternal-Fetal & Neonatal Medicine. 25 (10): 2082-7. doi:10.3109/14767058.2012.671871. PMID 22394270.. ...
Sun exposureEdit. The use of sunscreen with a sun protection factor of 8 can theoretically inhibit more than 95% of vitamin D ... Maternal vitamin D deficiency causes the neurodevelopmental defects during the prenatal development of the brain, that are ... Lack of vitamin D, inadequate sunlight exposure. Diagnostic method. measuring the concentration of the calcifediol in the blood ... Those most likely to be affected by vitamin D deficiency are people with little exposure to sunlight.[19] Certain climates, ...
Bornehag, CG; Nanberg, E (2010 Apr). "Phthalate exposure and asthma in children.". International journal of andrology 33 (2): ... Dietert, RR (2011 Sep). "Maternal and childhood asthma: risk factors, interactions, and ramifications.". Reproductive ... Murk, W; Risnes, KR, Bracken, MB (2011 Jun). "Prenatal or early-life exposure to antibiotics and risk of childhood asthma: a ... Lodge, CJ; Allen, KJ; Lowe, AJ; Hill, DJ; Hosking, CS; Abramson, MJ; Dharmage, SC (2012). "Perinatal cat and dog exposure and ...
Seg5 Problem List, Seg6 Immunizations, Seg7 Exposure to Hazardous Substances, Seg8 Family/Prenatal/Cumulative Health/Medical/ ...
Exposure to exhaust gasses from large amounts of vessel traffic are causing concern for the overall health of the 75 remaining ... and common but older maternal heritage. Clan ranges overlap, mingling pods from different clans.[142] The final association ... A 2018 study published in Science found that global killer whale populations are poised to dramatically decline due to exposure ... "Estimation of southern resident killer whale exposure to exhaust emissions from whale-watching vessels and potential adverse ...
These concerns consisted of the spread of communicable and infectious disease, migrant maternal health, and occupational ... mobility and their concentration in hazardous industries continue to make it difficult to reduce their exposure to ...
... exposure to fluoridated water during pregnancy and their childrens IQ scores. ... Fluoridated water: Maternal exposure may affect childrens IQs. Written by Ana Sandoiu on August 22, 2019 - Fact checked by. ... The researchers used two measures of fluoride exposure during pregnancy: They used data on "maternal urinary fluoride (MUF) ... "Fluoride exposure during pregnancy may be associated with adverse effects on child intellectual development, indicating the ...
Methamphetamine concentrations in fetal and maternal brain following prenatal exposure.. Won L1, Bubula N, McCoy H, Heller A. ... Levels of methamphetamine in maternal striatum and whole fetal mouse brain were assessed at 0.5, 1, 2, and 4 h postinjection on ... Maternal administration of methamphetamine results in fetal brain drug concentrations, which approximate those reported in ...
137Cesium Chronic contamination Cytochrome P450 Vitamin D3 Maternal exposure Abbreviations. 1,25(OH)2D3. 1α,25-Dihydroxyvitamin ... Vitamin D metabolism impairment in the rats offspring following maternal exposure to 137cesium. ... Messiha FS (1988) Maternal cesium chloride ingestion and the newborn. Neurosci Biobehav Rev 12(3-4):209-213PubMedCrossRefGoogle ... Handl J, Beltz D, Botsch W, Harb S, Jakob D, Michel R, Romantschuk LD (2003) Evaluation of radioactive exposure from 137Cs in ...
... study investigated the association between major musculoskeletal malfor-mations and periconceptional maternal occupational ... pesticide exposure for a wide range of occupations.We conducted a multi-site case-control analysis using data from the National ... Prenatal-exposure; Author Keywords: Pesticides; Maternal occupational exposure; Craniosynostosis; Gastroschisis; Diaphragmatic ... Using self-reported maternal occupational information, an indus-trial hygienist used a job-exposure matrix and expert opinion ...
METHODS: This is a secondary analysis of data from a multicenter project, the Maternal Lifestyle Study, designed to determine ... Four centers of the National Institute of Child Health and Human Development Neonatal Research Network enrolled 11,811 maternal ... infant outcomes of in utero cocaine or opiates exposure. ... To estimate the effects of cocaine exposure on intrauterine ... Gestational cocaine exposure and intrauterine growth: Maternal lifestyle study. Obstetrics and Gynecology, 100(5), 916-924. ...
... Stress. 2014 Mar;17(2):133-48. doi: 10.3109/ ... The effects of prenatal maternal stress (PNMS) on the developing immune system have been documented mostly through animal ...
Objectively measured tobacco exposure during pregnancy: neonatal effects and relation to maternal smoking.. Bardy AH1, Seppälä ... Tobacco exposure was assessed from maternal serum samples, obtained during the first half of pregnancy and from umbilical serum ... To measure quantitatively and objectively the maternal and fetal tobacco exposure during pregnancy and its neonatal effects. ... One micrograms/ml of cotinine in maternal serum resulted in a mean decrease of 1.29 g (95% CI 0.55-2.02 g) in birthweight and ...
Thus, exposure to maternal depression and prenatal SRI exposure appear to exhibit opposite effects on the development of infant ... Given the neurobehavioral consequences of SRI exposure and depressed maternal mood, we asked whether exposure to SRIs or to ... In summary, we have found that exposure to SRIs accelerates speech perception development, whereas exposure to maternal ... language development is altered by prenatal exposure to SRIs and whether such effects differ from exposure to maternal mood ...
Lobjectif de ce document est de définir une procédure efficace pour mener des activités de contrôle de la qualité afin de garantir la fiabilité des résultats obtenus dans le cadre des études de biosurveillance humaine du ...
Maternal HIV Testing and Identification of Perinatal HIV Exposure. The information in the brief version is excerpted directly ... Maternal HIV Testing and Identification of Perinatal HIV Exposure. *Counseling and Management of Women Living with HIV Who ... Maternal HIV Testing and Identification of Perinatal HIV Exposure. Last Updated: April 16, 2019; Last Reviewed: April 16, 2019 ... Panels Recommendations for Maternal Testing and Identification of Perinatal HIV Exposure. Panels Recommendations ...
... although described for high-dose exposure, could ever be confirmed for e ... only a few studies investigated occupational exposure to ionizing radiation in pregnancy to cause birth defects (BDs). No ... In 3,816 births (including 165 infants with BDs; 4.3%), maternal answers concerning possible exposures to medical and ... So far, only a few studies investigated occupational exposure to ionizing radiation in pregnancy to cause birth defects (BDs). ...
... Ravindra ... Fung-Kei Cheng, "Taijiao: a traditional Chinese approach to enhance fetal growth through maternal physical and mental health ... Giuseppina Persico, Laura Antolini, Patrizia Vergani, Walter Costantini, Maria Teresa Nardi, and Lidia Bellotti, "Maternal ... nuevos contenidos y retos en los programas de educación maternal," Enfermería Clínica, 2015. View at Publisher · View at Google ...
We sought to extend this literature using interview data combined with detailed exposure assessment. Methods: Data for 1997- ... there is only one previous study of occupational PAH exposure and adverse pregnancy outcomes. ... While some of the highest maternal exposures to polycyclic aromatic hydrocarbons (PAHs) occur in the workplace, ... After adjustment for maternal age, there was a significant association of occupational exposure with SGA (OR=2.2, 95% CI 1.3 to ...
... PLoS One. 2010 Jul 30;5(7):e11896. ... In a population-based cohort study, we examined whether prenatal stress related to maternal bereavement during pregnancy was ...
The way in which mothers regulate their childrens sun exposure may be affected by... ... However, the use of maternal reports of sun-exposure may reduce the validity of the data as mothers may not be aware of their ... Influence of maternal and own genotype at tanning dependence-related SNPs on sun exposure in childhood. ... UV exposure (either by sun exposure or tanning equipment such as sun beds) can cause skin damage which is associated with the ...
Exposure to hypertensive disorders of pregnancy (HDP) may be associated with an increase in the risk of autism spectrum ... Home › News › Professional › Exposure to Maternal HTN May Up Risk of ASD, ADHD in Child ... Exposure to Maternal HTN May Up Risk of ASD, ADHD in Child. Print this page ... There were no statistically significant differences for ASD or ADHD in subgroup analyses according to type of exposure (i.e., ...
... may affect maternal health and neonatal outcomes, but that uniform standards for assessing the effects of heat on maternal ... We included articles that identify climate change-related exposures and adverse health effects for pregnant women. There is ... including maternal and fetal health. This systematic review aims to identify recent literature that investigates increasing ... and neonatal stress in unusually hot temperature exposures. The studies included in this review indicate that not only is there ...
Maternal exposure to polycyclic aromatic hydrocarbons diminishes murine ovarian reserve via induction of Harakiri. ... Maternal exposure to polycyclic aromatic hydrocarbons diminishes murine ovarian reserve via induction of Harakiri. ... Our data indicate that maternal exposure to PAHs prior to pregnancy and/or during lactation compromises ovarian reserve of ... Maternal smoking during pregnancy is associated with a variety of adverse neonatal outcomes including altered reproductive ...
EMBRACE (Evaluation of Maternal and Baby Outcome Registry After Chemoprophylactic Exposure) (EMBRACE). This study is currently ... The Prevention Agent Pregnancy Exposure Registry, also known as EMBRACE (Evaluation of Maternal and Baby Outcome Registry After ... The Prevention Agent Pregnancy Exposure Registry, also known as EMBRACE (Evaluation of Maternal and Baby Outcome Registry After ... Chemoprophylactic Exposure) is a prospective observational cohort study of maternal exposures to investigational HIV prevention ...
Maternal and Neurodevelopmental Outcomes of in Utero Antiepileptic Drug (AED) Exposure (MONEAD). The safety and scientific ... The Maternal Relative must be a full biological relative or half-sibling of the mother chosen by the following hierarchy:. *st ... Exposure to known teratogens during pregnancy, excluding AEDs.. *Detection of fetal major congenital malformation prior to ... An overall goal of this study is to establish the relationship between antiepileptic drug exposure and outcomes in the mother ...
Water district-level pesticide exposure was estimated by linking each maternal residential address to the corresponding public ... Our objective was to examine the relationship between estimated maternal exposure to pesticides in public drinking water and ... Estimated Maternal Pesticide Exposure from Drinking Water and Heart Defects in Offspring. Int. J. Environ. Res. Public Health ... "Estimated Maternal Pesticide Exposure from Drinking Water and Heart Defects in Offspring." Int. J. Environ. Res. Public Health ...
Prenatal Exposure to Maternal Infections increase Childs Risk of Schizophrenia. Read more... Schizophrenia Causes, Risk ... In this new study the authors examined the relation between a mothers exposure to maternal genital / reproductive infections ... Study: Prenatal Exposure to Maternal Genital and Reproductive Infections and Adult Schizophrenia ... CONCLUSIONS: Maternal genital/reproductive infection during conception and early pregnancy appears to increase the risk of ...
... exposure to maternal diabetes (odds ratio [OR] 5.7 [95% CI 2.4-13.4]) and exposure to maternal obesity (2.8 [1.5-5.2]) were ... mutually exclusive exposure categories were derived (i.e., exposure to maternal diabetes only, to maternal overweight/obesity ... CIs for the association of exposure to maternal diabetes in utero and exposure to maternal obesity in utero with type 2 ... The association between offspring type 2 diabetes status with exposure to maternal diabetes in utero (A) and exposure to ...
Why the Maternal Medication List Matters: Neonatal Toxicity From Combined Serotonergic Exposures. Michelle R. Brajcich, ... Why the Maternal Medication List Matters: Neonatal Toxicity From Combined Serotonergic Exposures ... Why the Maternal Medication List Matters: Neonatal Toxicity From Combined Serotonergic Exposures ... Why the Maternal Medication List Matters: Neonatal Toxicity From Combined Serotonergic Exposures ...
Another danger from fracking: Benzene exposure during pregnancy found to affect maternal health. Monday, December 18, 2017 by: ... Benzene exposure may negatively affect pregnancy. The research team has stressed that persistent exposure to muconic acid may ... Another danger from fracking: Benzene exposure during pregnancy found to affect maternal health ... www.naturalnews.com/2017-12-18-another-danger-from-fracking-benzene-exposure-during-pregnancy-found-to-affect-maternal-health. ...
Infant Acute Leukemia and Maternal Exposures during Pregnancy. Maria S. Pombo-de-Oliveira and Sergio Koifman ... Infant Acute Leukemia and Maternal Exposures during Pregnancy Message Subject (Your Name) has forwarded a page to you from ...
Maternal smoking during pregnancy, environmental tobacco smoke exposure and childhood lung function ... Maternal smoking during pregnancy, environmental tobacco smoke exposure and childhood lung function ...
Results of recent national surveys have shown the high prevalence of exposure to bisphenol A (BPA) and triclosan (TCS) among ... RESULTS: Triclosan was detected in over 80% of the maternal urines (geometric mean (GM): 21.61μg/L), 60% of the infant urines ( ... Median total BPA concentrations were 1.21 and 0.24μg/L in maternal and infant urines, respectively. Free BPA was detected in ... BACKGROUND: Results of recent national surveys have shown the high prevalence of exposure to bisphenol A (BPA) and triclosan ( ...
Maternal exposure to.... *Maternal exposure to angiotensin converting enzyme inhibitors in the first trimester and risk of ... Maternal exposure to antihypertensive drugs and risk of major malformations in offspring. Table 2⇓ presents results of the ... For maternal exposure during the first trimester only, use of ACE inhibitors was associated with about 20% increased risk of ... Maternal exposure to antihypertensive drugs and risk of congenital heart and neural tube defects in offspring. The association ...
Exposure to Maternal HTN May Up Risk of ASD, ADHD in Child. Last Updated: June 13, 2018. ... Exposure to hypertensive disorders of pregnancy may be associated with an increase in the risk of autism spectrum disorder and ... There were no statistically significant differences for ASD or ADHD in subgroup analyses according to type of exposure (i.e., ... WEDNESDAY, June 13, 2018 (HealthDay News) -- Exposure to hypertensive disorders of pregnancy (HDP) may be associated with an ...
  • METHODS: This is a secondary analysis of data from a multicenter project, the Maternal Lifestyle Study, designed to determine infant outcomes of in utero cocaine or opiates exposure. (rti.org)
  • Objectives: While some of the highest maternal exposures to polycyclic aromatic hydrocarbons (PAHs) occur in the workplace, there is only one previous study of occupational PAH exposure and adverse pregnancy outcomes. (cdc.gov)
  • There is evidence that temperature extremes adversely impact birth outcomes, including, but not limited to: changes in length of gestation, birth weight, stillbirth, and neonatal stress in unusually hot temperature exposures. (mdpi.com)
  • The studies included in this review indicate that not only is there a need for further research on the ways that climate change, and heat in particular, may affect maternal health and neonatal outcomes, but that uniform standards for assessing the effects of heat on maternal fetal health also need to be established. (mdpi.com)
  • Maternal smoking during pregnancy is associated with a variety of adverse neonatal outcomes including altered reproductive performance. (jci.org)
  • An overall goal of this study is to establish the relationship between antiepileptic drug exposure and outcomes in the mother and child as well as describe and explain the variability in antiepileptic drug exposure and response. (clinicaltrials.gov)
  • There is a compelling need for prospective, properly controlled studies in women with epilepsy (WWE) during pregnancy to improve maternal and child outcomes. (clinicaltrials.gov)
  • The research team has stressed that persistent exposure to muconic acid may result in adverse pregnancy outcomes as the chemical is classified as a degradation product of benzene, which is a toxic and carcinogenic compound. (naturalnews.com)
  • We reviewed and integrated findings from studies of aflatoxin exposure during pregnancy and evaluated potential links to adverse pregnancy outcomes. (ajtmh.org)
  • We identified 27 studies (10 human cross-sectional studies and 17 animal studies) assessing the relationship between aflatoxin exposure and adverse birth outcomes or anemia. (ajtmh.org)
  • Given the widespread exposure to this toxin in developing countries, longitudinal studies in pregnant women are needed to provide stronger evidence for the role of aflatoxin in adverse pregnancy outcomes, and to explore biological mechanisms. (ajtmh.org)
  • However, lithium exposure was not associated with pregnancy complications or other delivery outcomes, such as pre-eclampsia, preterm birth, gestational diabetes, or low birth weight, the researchers said. (indiatvnews.com)
  • Although maternal obesity did not change the offspring's behavioral response to chronic stress per se, we demonstrate that the behavioral outcomes induced by prenatal exposure to maternal obesity parallel the deleterious effects of adult chronic stress exposure in aged male mice. (ebscohost.com)
  • Exposure to ambient air pollutants during pregnancy may be associated with numerous side health effects and adverse birth outcomes. (unboundmedicine.com)
  • We aimed to conduct a systematic review based on published cohort studies to summarize evidence regarding the association between maternal PM2.5 exposure and birth outcomes, including birth weight, low birth weight (LBW), preterm birth (PTB), and small for gestational age (SGA). (unboundmedicine.com)
  • Eligible studies meeting the following criterion were selected: PM2.5 exposure during pregnancy and live birth singletons, certain presentation of sample sizes, and quantitative evaluation of the associations between exposure and outcomes. (unboundmedicine.com)
  • So far, linkages between maternal PM2.5 exposure during varied gestational stages and multiple adverse birth outcomes have been observed in many studies. (unboundmedicine.com)
  • A summary of them will be meaningful for further research on maternal exposure and adverse birth outcomes. (unboundmedicine.com)
  • Objectives Maternal exposure to lead (Pb) has been suggested to correlate with adverse birth outcomes, but evidence supporting an association between Pb exposure and premature rupture of membranes (PROM) is limited. (bmj.com)
  • 1-3 PROM is related to significant maternal, fetal and neonatal risks, such as maternal infection, prematurity, neonatal sepsis and adverse neurological outcomes. (bmj.com)
  • To approach the intersection between environmental health and women's health, it can be helpful to organize the exposures and outcomes. (contemporaryobgyn.net)
  • These exposures can be thought of in two general categories-toxic chemicals and climate change-related and air pollution exposures-affecting three ob/gyn health outcomes: fertility and pregnancy, neurodevelopmental impairment, and cancer. (contemporaryobgyn.net)
  • The American College of Obstetricians and Gynecologists (ACOG) and the International Federation of Gynecology and Obstetrics (FIGO) have issued guidance on the numerous ob/gyn health outcomes at risk due to these toxic environmental exposures as they concern fertility and pregnancy, neurodevelopmental impairment, and cancer (Table 2). (contemporaryobgyn.net)
  • Exposure to tobacco smoke during pregnancy, whether as active smoking or by exposure to secondhand smoke (SHS), is associated with adverse pregnancy outcomes including low birth weight (LBW) and small for gestational age infants due to the effect of tobacco on the anthropometric measurements of the newborn. (biomedcentral.com)
  • Q: How did postnatal behavioral outcomes vary in infants across the continuum of exposure in your study? (primarypsychiatry.com)
  • Maternal cumulative exposure to extremely low frequency electromagnetic fields and pregnancy outcomes in the Elfe cohort. (emf-portal.org)
  • A prospective cohort study was conducted in France to examine the association between occupational and residential maternal exposures to extremely low frequency magnetic fields and pregnancy outcomes. (emf-portal.org)
  • Maternal residential proximity to sources of extremely low frequency electromagnetic fields and adverse birth outcomes in a UK cohort. (emf-portal.org)
  • Perturbations in early life environments, including intrauterine exposure to maternal gestational diabetes (GDM), are hypothesized to lead to metabolic imprinting resulting in increased risk of cardiometabolic outcomes later in life. (infona.pl)
  • However, ETS exposure had no impact on the risk of either SGA or LBW at term alone and the reviewers noted that empirical studies were conducted in widely varied settings and often small and of poor quality, reporting only crude (i.e. non-adjusted) birth outcomes. (biomedcentral.com)
  • In addition to utilizing biomarkers of STS exposure, future studies should aim to identify vital windows of STS exposure, important environmental co-exposures, individual susceptibility factors, and specific STS constituents associated with female infertility and adverse pregnancy outcomes. (eurekaselect.com)
  • John D. Meeker and Merle D. Benedict, "Infertility, Pregnancy Loss and Adverse Birth Outcomes in Relation to Maternal Secondhand Tobacco Smoke Exposure", Current Women`s Health Reviews (2013) 9: 41. (eurekaselect.com)
  • Factors such as genetics, polydrug exposure, environmental toxins, stress, and maternal care are likely to influence developmental outcomes in opioid exposed embryos and fetuses. (cloudfront.net)
  • Exposures to environmental chemicals and psychosocial stressors during pregnancy have been individually associated with adverse perinatal outcomes related to birthweight and gestational age, but are not often considered in combination. (elsevier.com)
  • We review types of psychosocial stressors and instruments used to assess them and classes of environmental chemical exposures that are known to adversely impact perinatal outcomes, and identify studies relevant studies. (elsevier.com)
  • We discuss the National Institutes of Health's Environmental influences on Child Health Outcomes (ECHO) program that has combined existing longitudinal cohorts that include more than 50,000 children across the U.S. We describe future opportunities for investigators to use this important new resource for addressing relevant and critical research questions to maternal health. (elsevier.com)
  • on behalf of program collaborators for Environmental influences on Child Health Outcomes 2020, ' A review of maternal prenatal exposures to environmental chemicals and psychosocial stressors-implications for research on perinatal outcomes in the ECHO program ', Journal of Perinatology , vol. 40, no. 1, pp. 10-24. (elsevier.com)
  • Levels of methamphetamine in maternal striatum and whole fetal mouse brain were assessed at 0.5, 1, 2, and 4 h postinjection on gestational day 14 (GD14) following a single, subcutaneous injection of 40 mg/kg (+)-methamphetamine hydrochloride to pregnant mice. (nih.gov)
  • Tobacco exposure was associated with shorter gestational age, reduced birthweight and shorter crown-heel length of the newborns. (nih.gov)
  • There is a quantitative dose and effect relation between tobacco exposure and a decrease in the gestational age at birth and size of the neonate. (nih.gov)
  • Maternal occupational exposure to polycyclic aromatic hydrocarbons and small for gestational age offspring. (cdc.gov)
  • In this context, the Fifth International Workshop on Gestational Diabetes Mellitus ( 10 ) has recommended studies of in utero exposure to maternal diabetes and obesity and type 2 diabetes in youth in populations other than American Indians. (diabetesjournals.org)
  • These data suggest that maternal exposure during the entire gestational period with low doses of nicotine and CPF, alone and in combination, does not lead to any significant observable developmental abnormalities in the offspring by PND 30. (epa.gov)
  • A significant body of literature has linked gestational day 12 (G12) heavy ethanol exposure with social anxiety, evident in adolescent males and females. (frontiersin.org)
  • The study has elaborates the link between increased expressions of autistic-like behaviours in pre-school aged children to gestational exposure to selected environmental toxicants. (ndtv.com)
  • A novel study found correlations between increased expressions of autistic-like behaviours in pre-school aged children to gestational exposure to selected environmental toxicants, including metals, pesticides, polychlorinated biphenyls (PCBs), phthalates, and bisphenol-A (BPA). (ndtv.com)
  • Maternal obesity and excessive gestational weight gain have been identified as factors that contribute to increased obesity in the offspring. (plos.org)
  • Among 18 studies that explored the correlation between prenatal exposure and PTB, 9 reached a consistent conclusion that gestational exposure would add to the risk of PTB. (unboundmedicine.com)
  • Therefore, we developed a novel maternal-fetal physiologically based pharmacokinetic (m-f-PBPK) model to predict fetal exposure to drugs and populated this model with gestational age-dependent changes in maternal-fetal physiology. (aspetjournals.org)
  • Our simulations yielded novel insights into the quantitative contribution of fetoplacental metabolism and/or placental transport on gestational age-dependent fetal drug exposure. (aspetjournals.org)
  • The proposed m-f-PBPK model can be used to predict fetal exposure to drugs across gestational ages and therefore provide the necessary information to assess the risk of drug toxicity to the fetus. (aspetjournals.org)
  • as pre-existing maternal conditions (e.g., epilepsy, asthma) or conditions that developed during pregnancy (e.g., gestational diabetes and hypertension) must be treated to ensure the health and welfare of the mother and therefore her fetus. (aspetjournals.org)
  • This study was designed to establish whether gestational and lactational exposure to the plasticizer di(2-ethylhexyl)phthalate (DEHP) at environmental doses promotes transgenerational effects on reproductive health in female offspring, as adults, over three generations in the mouse. (ovid.com)
  • Distinct alterations in motor & reward seeking behavior are dependent on the gestational age of exposure to LPS-induced maternal immune activation. (drugsandalcohol.ie)
  • Straley, Megan E and Van Oeffelen, Wesley and Theze, Sarah and Sullivan, Aideen M and O'Mahony, Siobhain M and Cryan, John F and O'Keeffe, Gerard W (2016) Distinct alterations in motor & reward seeking behavior are dependent on the gestational age of exposure to LPS-induced maternal immune activation. (drugsandalcohol.ie)
  • No statistically significant association was found between maternal cumulative exposure and premature birth between 33 and 37 weeks of gestation and small for gestational age in this exposure range. (emf-portal.org)
  • The authors conclude that this large population-based study does not suggest that maternal exposure to extremely low frequency magnetic fields during pregnancy is highly associated with risks of premature birth between 33 and 37 weeks of gestation or small for gestational age. (emf-portal.org)
  • It is not known, however, whether such early gestational and/or lactational exposure can influence the later adult-type Leydig cell phenotype. (nottingham.ac.uk)
  • Multiple candidate genes and the UPS were identified for future study as possible links between exposure to maternal gestational diabetes in utero and adverse cardiometabolic traits in the offspring. (infona.pl)
  • OBJECTIVE -Limited data exist on the association between in utero exposure to maternal diabetes and obesity and type 2 diabetes in diverse youth. (diabetesjournals.org)
  • Here, we investigated the effects of in utero exposure to maternal infection and noninfectious diseases during pregnancy on offspring developmental vulnerabilities at age 5 years, in the context of estimated effects for early childhood exposures to infectious and noninfectious diseases and maternal mental illness. (ovid.com)
  • The researchers used two measures of fluoride exposure during pregnancy: They used data on "maternal urinary fluoride (MUF) concentrations" as well as self-reported intake of tap water and other drinks containing water, such as tea and coffee . (medicalnewstoday.com)
  • Methamphetamine concentrations in fetal and maternal brain following prenatal exposure. (nih.gov)
  • Maternal administration of methamphetamine results in fetal brain drug concentrations, which approximate those reported in human infants whose mother abused methamphetamine. (nih.gov)
  • Maternal cotinine concentrations better explained the neonatal findings than the reported smoking habits. (nih.gov)
  • Data on maternal urinary fluoride concentrations and children's IQ were available for 512 mother-child pairs, and self-reported consumption of tap water and other water-based drinks (tea and coffee) and IQ scores were available for 400 of the 601 mother-child pairs. (medindia.net)
  • The experts have also observed that five of these women have had muconic acid concentrations that exceeded the biological exposure index (BEI). (naturalnews.com)
  • Median total BPA concentrations were 1.21 and 0.24μg/L in maternal and infant urines, respectively. (biomedsearch.com)
  • The researchers found that higher maternal concentrations of cadmium, lead, and some phthalates in blood or urine samples was associated with increased SRS scores, and these associations were particularly strong among children with a higher degree of autistic-like behaviours. (ndtv.com)
  • Interestingly, the study also noted that increased maternal concentrations of manganese, trans-Nonachlor, many organophosphate pesticide metabolites, and mono-ethyl phthalate (MEP) were most strongly associated with lower SRS scores. (ndtv.com)
  • Results The IQR of maternal urinary Pb concentrations of the study population was 2.30-5.64 µg/g creatinine with a median of 3.44 µg/g creatinine. (bmj.com)
  • Lastly, from July-September 2014, we collected unhatched eggs and liver and yolk sacs from dead-in-nest hatchlings from nests laid by the sampled females and tested these samples for brevetoxin concentrations to determine maternal transfer and effects on reproductive success. (ucsd.edu)
  • We found that plasma brevetoxin concentrations determined by an ELISA in nesting females positively correlated with gamma-globulins, indicating a potential for immunomodulation as a result of brevetoxin exposure. (ucsd.edu)
  • ¹⁴C]-DBC (GD 17) dosing revealed transplacental distribution to fetal tissues at 10-fold lower concentrations than in paired maternal tissue and residual [¹⁴C] 3 weeks post dose. (oregonstate.edu)
  • Through sensitivity analyses, we demonstrated that the UV/MP ratio does not measure the extent of fetal drug exposure unless obtained at steady state after an intravenous infusion or when there is little or no fluctuation in MP drug concentrations after multiple-dose oral administration. (aspetjournals.org)
  • Maternal xenobiotic treatment appeared to modify specific Leydig cell gene expression in male offspring, particularly during the dynamic phase of mid-puberty, with serum INSL3 concentrations showing that these compounds led to a faster attainment of peak values, and a modest acceleration of the pubertal trajectory. (nottingham.ac.uk)
  • A total of 1072 infants were cocaine exposed, 7565 were cocaine negative by maternal history and meconium results, and 3174 were excluded from analysis because of unconfirmed negative exposure. (rti.org)
  • We studied whether infants' language development is altered by prenatal exposure to SRIs and whether such effects differ from exposure to maternal mood disturbances. (pnas.org)
  • Infants with initial positive HIV viral tests (RNA, DNA) should have their ARV regimen modified, if necessary, to a three-drug combination of ARV drugs at treatment doses (see Antiretroviral Management of Newborns with Perinatal HIV Exposure or Perinatal HIV ) (AII) . (nih.gov)
  • HIV testing to determine HIV status is recommended for infants and children in foster care and adoptees for whom maternal HIV status is unknown (AIII) . (nih.gov)
  • CONCLUSIONS: We found widespread exposure among pregnant women and infants to environmental phenols, with large inter-individual variability in exposure to triclosan. (biomedsearch.com)
  • Among the 42 selected studies, 23 evaluated the impact of prenatal PM2.5 exposure on birth weight of infants while 12 of them provided a significantly negative association for exposure and birth weight. (unboundmedicine.com)
  • The objectives of this study were to estimate the independent effects of maternal exposure to SHS and maternal body mass index (BMI) on the anthropometric measurements and on the prevalence of macrosomia and LBW among term infants. (biomedcentral.com)
  • 18 kg/m 2 , non-obese 18-29.9 kg/m 2 , and obese ≥30 kg/m 2 ) and the SHS exposure status (exposed and non- exposed), to examine the independent effects of BMI and SHS on infants' anthropometry. (biomedcentral.com)
  • Exposure to SHS was associated with reduced anthropometric measurements of the newborn and increased rate of LBW infants, irrespective of maternal BMI. (biomedcentral.com)
  • Some of these signs were similar to infants who show withdrawal behaviors after in utero opiate exposure, so it was suggested that these infants were experiencing withdrawal from the antidepressants medication. (primarypsychiatry.com)
  • Four groups of infants were included in the study: exposure to SSRI-only, exposure to SSRI+benzodiazepine, exposure to maternal depression with no pharmacological treatment, and no exposure to maternal depression or psychotropics. (primarypsychiatry.com)
  • We expected infants in the non-treated maternal depression group and in the two SSRI-exposed groups to have worse scores for arousal, attention, and lethargy compared to control group across all time points. (primarypsychiatry.com)
  • None of the full-term infants in the study appeared to have any serious adverse events that could be attributed to medication or depression exposure. (primarypsychiatry.com)
  • Infants with SSRI+benzodiazepine exposure continued to have lower quality of movement and lower self-regulation than other infants at day 30, as well. (primarypsychiatry.com)
  • 2.5 Kg (LBW) in infants born to women exposed to: i) no tobacco smoke, ii) ETS only and iii) maternal smoking whilst pregnant. (biomedcentral.com)
  • 13% of UK infants were exposed to ETS and 36% to maternal smoking ante natally. (biomedcentral.com)
  • Compared to no ante natal tobacco smoke exposure, domestic ETS lowered infants' adjusted mean birth weights by 36 g (95% CI, 5 g to 67 g) and this effect showed a dose-response relationship. (biomedcentral.com)
  • UK prevalences of domestic ETS exposure and maternal smoking in pregnancy remain high and ETS exposure lowers infants' birth weights. (biomedcentral.com)
  • Outcome comparisons of maternal opioid use to different medication assisted therapies in infants diagnosed of NAS. (cloudfront.net)
  • The study's conclusions are limited by its observational design, which can't account for unmeasured factors that could explain the results, and there was no assessment of children's fluoride exposure during infancy. (medindia.net)
  • Conclusions: Maternal occupational exposure to PAHs was found to be associated with increased risk of SGA offspring. (cdc.gov)
  • CONCLUSIONS -Intrauterine exposures to maternal diabetes and obesity are strongly associated with type 2 diabetes in youth. (diabetesjournals.org)
  • Conclusions Maternal use of ACE inhibitors in the first trimester has a risk profile similar to the use of other antihypertensives regarding malformations in live born offspring. (bmj.com)
  • Conclusions: These findings indicate that maternal obesity parallels the deleterious effects of adult chronic stress exposure, and furthermore identifies GR/FKBP51 signaling as a novel candidate pathway regulated by maternal obesity. (ebscohost.com)
  • Conclusions Women should take preventive measures or avoid exposure to mineral and organic dust as well as metal dust and fumes early in pregnancy as this could possibly affect foetal heart development. (sjweh.fi)
  • Conclusions Our study found that higher levels of maternal Pb exposure was associated with increased risk of PROM, indicating that exposure to Pb during pregnancy may be an important risk factor for PROM. (bmj.com)
  • CONCLUSIONS AND RELEVANCE Consistent with the emerging literature, this study suggests that in utero exposure to high levels of MF nonionizing radiationwas associated with an increased risk of ADHD, especially ADHD with immune-related comorbidity. (avaate.org)
  • Conclusions: Our findings suggested that maternal exposure to ceiling void PM has the capacity to impair early somatic growth and alter early life immune development in a sex specific manner. (edu.au)
  • Conclusions: There was little evidence for a relation between risk of hypospadias and maternal occupation or occupational exposure to potential EDCs, but as the exposure classification was necessarily crude, these findings should be interpreted with caution. (manchester.ac.uk)
  • Maternal periconceptional occupational exposure to pesticides and selected musculoskeletal birth defects. (cdc.gov)
  • Using self-reported maternal occupational information, an indus-trial hygienist used a job-exposure matrix and expert opinion to evaluate the potential for exposure toinsecticides, herbicides or fungicides for each job held during one month pre-conception through threemonths post-conception. (cdc.gov)
  • Maternal occupational exposure to ionizing radiation and birth defects. (biomedsearch.com)
  • So far, only a few studies investigated occupational exposure to ionizing radiation in pregnancy to cause birth defects (BDs). (biomedsearch.com)
  • Additionally, a study-specific questionnaire distributed among all becoming mothers in the surveyed regions included questions on maternal occupational exposure to ionizing radiation within the first trimester of pregnancy. (biomedsearch.com)
  • 4.3%), maternal answers concerning possible exposures to medical and occupational ionizing radiation were available. (biomedsearch.com)
  • Relative risk (RR) estimates in mothers surveyed for occupational exposure to ionizing radiation (wearing a radiation dosimeter) and BDs in the offspring were calculated exploratively. (biomedsearch.com)
  • Two industrial hygienists independently assessed occupational exposure to PAHs from the interview and reviewed results with a third to reach consensus. (cdc.gov)
  • Occupational PAH exposure was found for 17 (7.7%) of the mothers with SGA offspring and 102 (4.0%) of the remaining mothers. (cdc.gov)
  • After adjustment for maternal age, there was a significant association of occupational exposure with SGA (OR=2.2, 95% CI 1.3 to 3.8). (cdc.gov)
  • Nondisjunction has not been found to be associated with environmental factors such as occupational exposures. (wikibooks.org)
  • This study aims to examine the association between maternal occupational exposures to organic and mineral dust, solvents, pesticides, and metal dust and fumes and CHD in the offspring, assessing several subgroups of CHD. (sjweh.fi)
  • Information on maternal jobs held early in pregnancy was collected via self-administered questionnaires, and job titles were linked to occupational exposures using a job exposure matrix. (sjweh.fi)
  • Any maternal occupational exposure was associated with a lower risk of aortic stenosis (OR adj 0.32, 95% CI 0.11-0.94). (sjweh.fi)
  • To study the relations between maternal occupational exposure to solvents during pregnancy and the risk of congenital malformations. (bmj.com)
  • Occupational exposure to solvents at the beginning of pregnancy was assessed from the women's self-reported occupational exposures at inclusion and from a job-exposure matrix (JEM). (bmj.com)
  • Significant associations were found between major congenital malformations and maternal occupational exposure to solvents, assessed by both self-report odds ratio (OR = 2.48, 95% CI 1.4 to 4.4 for regular exposure vs no exposure) and the JEM (OR = 3.48, 95% CI 1.4 to 8.4 for highest level of exposure vs no exposure). (bmj.com)
  • A small prospective cohort, 10 and a meta-analysis, 11 performed by the same research group both report associations between maternal occupational exposure to solvents and major malformations. (bmj.com)
  • Various case-control studies have shown relations between maternal occupational exposure to solvents and some subtypes of malformations, mostly oral clefts. (bmj.com)
  • Parental occupational exposures to electromagnetic fields and radiation and the incidence of neuroblastoma in offspring. (emf-portal.org)
  • Therefore, we conducted a case-control study assessing the association between estimated maternal occupational exposure to PAHs and CHDs in offspring. (cdc.gov)
  • Methods: Data (1980-96) from the National Congenital Anomaly System (NCAS) were used to analyse the proportion of all congenital anomaly cases (n = 35 962) which were notified with hypospadias (n = 3471) by occupational codes (348 individual job titles) and by categories of exposure to potential EDCs from a job exposure matrix. (manchester.ac.uk)
  • Overall, 47.2% (95% CI 30.9-63.5) of type 2 diabetes in youth could be attributed to intrauterine exposure to maternal diabetes and obesity. (diabetesjournals.org)
  • In particular, increased methylation of PYGO1 and CLN8 may be biological links between intrauterine exposure to maternal diabetes and significantly increased VCAM-1 levels in the offspring. (infona.pl)
  • To study the effect of maternal HF diet and maternal phenotype on the offspring, we have used a nonhuman primate (NHP) model where female Japanese macaques are maintained on a chronic HF diet ( 12 - 15 ). (diabetesjournals.org)
  • however, the effect of maternal exposure to community-sampled PM on early post-natal lung and immune development is poorly understood. (edu.au)
  • Effect of Maternal Electroacupuncture on Perinatal Nicotine Exposure-Induced Lung Phenotype in Offspring. (escholarship.org)
  • NIDA is interested in funding research on the effect of maternal opioid exposure on embryonic, fetal and post-natal brain development. (cloudfront.net)
  • This study analyzed the relationship of maternal diet and in utero exposure to organochlorine pesticides (OCPs) with newborn weight in mothers and newborns from Southern Spain. (diva-portal.org)
  • Herein we provide molecular evidence for a pathway involved in the elimination of the female germline due to prepregnancy and/or lactational exposure to polycyclic aromatic hydrocarbons (PAHs), environmental toxicants found in cigarette smoke. (jci.org)
  • In utero exposures to maternal diabetes and obesity were recalled by biological mothers. (diabetesjournals.org)
  • This association was independent of maternal obesity, father's diabetes, age at onset of diabetes in either parent, and offspring's birth weight and later obesity ( 2 , 3 ). (diabetesjournals.org)
  • Recent studies have shown an association between maternal prepregnancy obesity and excessive neonatal growth and adiposity ( 4 ), independent of diabetes in pregnancy. (diabetesjournals.org)
  • There is increasing interest in the hypothesis that maternal obesity during pregnancy, even in the absence of frank diabetes, is also associated with lifelong metabolic abnormalities in offspring, such as the presence of obesity ( 5 ) and features of the metabolic syndrome ( 6 ). (diabetesjournals.org)
  • However, no study has specifically explored an association between exposure to maternal prepregnancy obesity and type 2 diabetes in youth. (diabetesjournals.org)
  • Studies in rodents have shown that maternal high-fat (HF) diet and insulin resistance during pregnancy leads to offspring obesity and hepatic lipid accumulation ( 8 - 11 ). (diabetesjournals.org)
  • Background: There is growing evidence that maternal obesity and prenatal exposure to a high-fat diet program fetal development to regulate the physiology and behavior of the offspring in adulthood. (ebscohost.com)
  • In the current study we tested whether prenatal exposure to maternal obesity increases the offspring's vulnerability to stress-related psychiatric disorders. (ebscohost.com)
  • Methods: We used a mouse model of maternal diet-induced obesity to investigate whether maternal obesity affects the response to adult chronic stress exposure in young adult (3-month-old) and aged adult (12-month-old) offspring. (ebscohost.com)
  • Results: Long-lasting, delayed impairments to anxiety-like behaviors and stress coping strategies resulted on account of prenatal exposure to maternal obesity. (ebscohost.com)
  • We found that the glucocorticoid receptor (GR, Nr3c1 ) is upregulated in various hypothalamic nuclei on account of maternal obesity. (ebscohost.com)
  • In animal models, exposure to maternal obesity and high fat diets influences the risk of obesity in the offspring. (plos.org)
  • Using a rat model of overfeeding-induced obesity, we previously demonstrated that exposure to maternal obesity from pre-conception to birth, is sufficient to program increased obesity risk in the offspring. (plos.org)
  • Since, disruptions of diurnal circadian rhythm are known to detrimentally impact metabolically active tissues such as liver, we examined the hypothesis that maternal obesity leads to perturbations of core clock components and thus energy metabolism in offspring liver. (plos.org)
  • Hepatic mRNA expression of circadian (CLOCK, BMAL1, REV-ERBα, CRY, PER) and metabolic (PPARα, SIRT1) genes were strongly suppressed in offspring exposed to both maternal obesity and HFD. (plos.org)
  • In animal models, exposure to maternal obesity unambiguously influences the risk of obesity in the offspring [14] - [18] . (plos.org)
  • Embryonic and fetal exposure to maternal obesity causes several maladaptive morphological and epigenetic changes in exposed offspring. (biomedcentral.com)
  • The timing of these events is unclear, but changes can be observed even after a short exposure to maternal obesity around the time of conception. (biomedcentral.com)
  • The hypothesis of this work is that maternal obesity influences the ovine preimplantation conceptus early in pregnancy, and this exposure will affect gene expression in embryonic and extraembryonic tissues. (biomedcentral.com)
  • 0.05 FDR) were detected based on maternal obesity exposure ( n = 21). (biomedcentral.com)
  • Also, differential effects of maternal obesity were noted on each conceptus sex ( n = 347). (biomedcentral.com)
  • Findings reveal that the preimplantation ovine conceptus genome responds to maternal obesity in a sex-dependent manner. (biomedcentral.com)
  • Lifestyle choices and poor diet are recognized as the main factors leading to obesity, however, more recent evidence suggests that intrauterine exposure to an obesogenic environment is a contributing factor predisposing offspring to obesity-related disorders. (biomedcentral.com)
  • While the effects of maternal obesity are known to have lasting effects in offspring, methods to alleviate these effects are lacking. (biomedcentral.com)
  • This effect might be masked by maternal obesity as it increases fetal weight. (biomedcentral.com)
  • Here, we investigated the effects of maternal n-3 polyunsaturated fatty acid (PUFA) diet on breast cancer risk of female offspring. (rsc.org)
  • In this study, we investigated the effects of maternal nicotine exposure during pregnancy and lactation on the blood pressure of the male offspring. (uwc.ac.za)
  • Four centers of the National Institute of Child Health and Human Development Neonatal Research Network enrolled 11,811 maternal-infant dyads. (rti.org)
  • Objectively measured tobacco exposure during pregnancy: neonatal effects and relation to maternal smoking. (nih.gov)
  • To measure quantitatively and objectively the maternal and fetal tobacco exposure during pregnancy and its neonatal effects. (nih.gov)
  • Neonatal providers should be aware of maternal medications and prepare for possible adverse effects, particularly from common psychotropic exposures. (aappublications.org)
  • These data suggest that oral neonatal exposure to non-inherited maternal red blood cell antigens through breastfeeding for at least two months diminishes the risk of alloimmunization against these antigens when encountered later in life. (haematologica.org)
  • We evaluated whether maternal exposure to 2,3,7,8-Tetrachlorodibenzo- p -dioxin (TCDD), a persistent and widespread toxic environmental contaminant, is associated with modified neonatal thyroid function in a large, highly exposed population in Seveso, Italy. (plos.org)
  • Our data indicate that environmental contaminants such as dioxins have a long-lasting capability to modify neonatal thyroid function after the initial exposure. (plos.org)
  • Preventing episodic exposure and withdrawal from acute opioids decreases the incidence of Intrauterine fetal demise, neonatal death, and prematurity. (cloudfront.net)
  • Exposures analyzed included any exposure (yes/no) to pesticides, to insecticidesonly, to both insecticides and herbicides (I + H) and to insecticides, herbicides and fungicides (I + H + F). Weused logistic regression to evaluate the association between exposures and defects, controlling for infantand maternal risk factors. (cdc.gov)
  • Our objective was to examine the relationship between estimated maternal exposure to pesticides in public drinking water and the risk of congenital heart defects (CHD). (mdpi.com)
  • Aris, A. and Leblanc, S. (2011) Maternal and Fetal Exposure to Pesticides Associated to Genetically Modified Foods in Eastern Townships of Quebec, Canada. (scirp.org)
  • See Antiretroviral Management of Newborns with Perinatal HIV Exposure or Perinatal HIV for guidance. (nih.gov)
  • Risk of neuroblastoma, maternal characteristics and perinatal exposures: The SETIL study. (emf-portal.org)
  • These codes are for use when the listed maternal conditions are specified as the cause of confirmed morbidity or potential morbidity which have their origin in the perinatal period (before birth through the first 28 days after birth). (icd10data.com)
  • however, whether acupuncture affects the lung damage caused by perinatal smoke exposure is not known. (escholarship.org)
  • To determine the effect of acupuncture on perinatal nicotine exposure on the developing lung, pregnant rat dams were administered (1) saline, (2) nicotine, or (3) nicotine + electroacupuncture (EA). (escholarship.org)
  • Finally, the analysis did not investigate or account for the potential effect of postnatal exposure to fluoride. (medicalnewstoday.com)
  • The neurotoxic effects in the offspring on postnatal day (PND) 30 were studied following maternal exposure to nicotine and CPF, alone and in combination. (epa.gov)
  • Suggested association between in utero exposure to measles and postnatal development of Crohn's disease. (safefetus.com)
  • Background: While the adverse metabolic effects of exposure to obesogenic diets during both the prenatal and early postnatal period are well established, the relative impact of exposure during these separate developmental windows remains unclear. (nottingham.ac.uk)
  • Fetal exposure to infectious and noninfectious diseases may influence early childhood developmental functioning, on the path to later mental illness. (ovid.com)
  • Fetal exposure to drugs has become increasingly common. (aspetjournals.org)
  • Consequently, the ability to quantitatively evaluate fetal exposure to drugs and risk of toxicity, not only at term but also earlier during pregnancy when the fetus is most vulnerable to teratogens, is needed. (aspetjournals.org)
  • Unlike the general population, fetal exposure to drugs ingested by the pregnant mother cannot be readily studied prior to birth for ethical and logistical reasons. (aspetjournals.org)
  • Even at the time of birth, assessment of fetal exposure to drugs is limited to a single cord plasma concentration measurement and reported as the umbilical vein (UV)/maternal plasma (MP) drug concentration ratio. (aspetjournals.org)
  • The effects of prenatal maternal stress (PNMS) on the developing immune system have been documented mostly through animal studies, but inconsistent results and methodological differences have hampered the complete understanding of these findings. (nih.gov)
  • Our findings suggest that maternal insulin resistance, including elevated triglycerides, insulin, and weight gain, initiates dysregulation of the juvenile hepatic immune system and development of de novo lipogenic pathways that persist in vitro and may be an irreversible "first hit" in the pathogenesis of NAFLD in NHP. (diabetesjournals.org)
  • These findings demonstrate that intrauterine exposure to maternal HF diet, independent of maternal metabolic effects, increases fetal hepatic steatosis. (diabetesjournals.org)
  • Findings suggest that aflatoxin exposure during pregnancy may impair fetal growth. (ajtmh.org)
  • The findings revealed subtle modifications in the maternal behavior of adolescent morphine-exposed females, primarily related to the amount of time females' spend nursing and in non-nursing contact with their young. (frontiersin.org)
  • These findings suggested that CAT was more susceptible to low- fluoride exposure in early life. (fluoridealert.org)
  • The findings should spur more research to examine the biological association of in utero MF exposure with risk of ADHD in offspring, given that almost everyone is exposed to it. (avaate.org)
  • The authors conclude that the findings do not support a major role of exposure to extremely low frequency magnetic fields for neuroblastoma occurrence in children . (emf-portal.org)
  • These findings indicate that in mice exposure to DEHP at doses relevant to human exposure during gonadal sex determination significantly perturbs the reproductive indices of female adult offspring and subsequent generations. (ovid.com)
  • Meta-analyses of studies investigating the impact of maternal environmental tobacco smoke (ETS) on birth weight have not produced robust findings. (biomedcentral.com)
  • We report the findings of such a study using data from the Millennium Survey, a contemporary UK epidemiological birth cohort, to investigate the UK prevalences of domestic ETS exposure and maternal smoking in pregnancy and the relative impact of these exposures on birth weight. (biomedcentral.com)
  • Rivka and colleagues conclude, "In this prospective birth cohort study, fluoride exposure during pregnancy was associated with lower IQ scores in children aged 3 to 4 years. (medicalnewstoday.com)
  • In a population-based cohort study, we examined whether prenatal stress related to maternal bereavement during pregnancy was associated with the risk of overweight in offspring during school age. (nih.gov)
  • To examine the potential association between maternal use of ACE inhibitors during the first trimester and the risk of malformations in offspring, especially congenital heart defects and neural tube defects, we conducted a large, population based, cohort study based on information from more than 465 000 mother-infant pairs from 1995 to 2008 in the Kaiser Permanente Northern California system. (bmj.com)
  • DESIGN, SETTING, AND PARTICIPANTS A longitudinal birth cohort study was conducted at Kaiser Permanente Northern California among 1482 mother-child pairs whose mothers were participants of an existing birth cohort and whose level of exposure to MF nonionizing radiation was captured during pregnancy in 2 studies conducted from October 1, 1996, to October 31, 1998, and from May 1, 2006, to February 29, 2012. (avaate.org)
  • We conducted a large, cohort study to assess the impact of ETS exposure on birth weight whilst adjusting for the many factors known to influence this. (biomedcentral.com)
  • Our data indicate that maternal exposure to PAHs prior to pregnancy and/or during lactation compromises ovarian reserve of female offspring, raising the concern about the transgenerational impact of maternal smoking on ovarian function in the human. (jci.org)
  • A prospective population-based cohort, specifically designed to study the impact of maternal exposure to solvents on the risk of congenital malformations, began in 2002 in three districts of Brittany (France). (bmj.com)
  • Impact of maternal opioid exposure on child stress responses. (cloudfront.net)
  • Results An association was found between organic dust exposure and coarctation of aorta [adjusted odds ratio (OR adj ) 1.90, 95% confidence interval (CI) 1.01-3.59] and pulmonary (valve) stenosis in combination with ventricular septal defect (OR adj 2.68, 95% CI 1.07-6.73). (sjweh.fi)
  • The main objective of this investigation was to establish the effects of maternal exposure of nano-TiO 2 on developing embryos. (dovepress.com)
  • We used Poisson regression to analyze births and malformations to estimate the association between maternal exposure to VOCs adjusting for sex, mother's age, race, education, parity, and prenatal care. (nih.gov)
  • IMPORTANCE An association between maternal exposure to magnetic field (MF) nonionizing radiation during pregnancy and the risk of attention-deficit/hyperactivity disorder (ADHD) has been reported in both animal and human studies. (avaate.org)
  • Fluoride exposure during pregnancy may be associated with adverse effects on child intellectual development, indicating the possible need to reduce fluoride intake during pregnancy. (medicalnewstoday.com)
  • Maternal fluoride exposure during pregnancy is associated with low IQ scores in their children aged 3 to 4, according to an observational study done on 601 mother-child pairs from six cities in Canada hints. (medindia.net)
  • This study analyzed two measures of fluoride exposure during pregnancy. (medindia.net)
  • The cytotoxic and systemic effects of aflatoxin could plausibly mediate maternal anemia, intrauterine growth restriction, fetal loss, and preterm birth. (ajtmh.org)
  • Potential pathways for intervention to reduce aflatoxin exposure are urgently needed, and this might reduce the global burden of stillbirth, preterm birth, and low birthweight. (ajtmh.org)
  • Primary maternal infection in pregnancy can be associated with preterm delivery. (safefetus.com)
  • The aim of our study was to investigate whether maternal Pb exposure was associated with PROM and preterm PROM. (bmj.com)
  • While the association between maternal STS exposure and declined birth weight has been fairly well-documented, only recently have epidemiologic studies begun to provide suggestive evidence for delayed conception, altered menstrual cycling, early pregnancy loss (e.g. spontaneous abortion), preterm delivery, and congenital malformations in relation to STS exposure. (eurekaselect.com)
  • This exposure during pregnancy has been associated with an increased risk of major congenital malformations in the offspring, especially oral clefts, urinary and male genital malformations. (bmj.com)
  • Among the Pima Indians, exposure to diabetes in utero was the strongest risk factor for development of type 2 diabetes in young offspring ( 3 ). (diabetesjournals.org)
  • We aimed to 1) identify candidate genes and biological pathways associated with differentially methylated regions (DMRs) in relation to exposure to GDM in utero and, 2) using mediation analysis, more definitively investigate the potential for mediation of the effect of exposure to maternal diabetes in utero on cardiometabolic traits in childhood risk through our identified DMRs. (infona.pl)
  • Increased methylation of PYGO1 and CLN8 had the greatest relative mediation effect (RME = 87%, p=0.005 and RME=50%, p=0.01) on the impact of exposure to maternal diabetes in utero on VCAM-1 levels in the offspring. (infona.pl)
  • The Prevention Agent Pregnancy Exposure Registry, also known as EMBRACE (Evaluation of Maternal and Baby Outcome Registry After Chemoprophylactic Exposure) is a prospective observational cohort investigation of exposures to study agents under investigation for HIV prevention. (clinicaltrials.gov)
  • The study population will consist of female participants who are identified as becoming pregnant during their participation in a microbicide or PrEP trial, or who have had planned exposures in pregnancy safety studies as well as their babies resulting from these pregnancies. (clinicaltrials.gov)
  • The study population will consist of current or recent female participants identified as becoming pregnant during microbicide or PrEP trials, or who have had planned exposures in pregnancy safety studies. (clinicaltrials.gov)
  • In this new study the authors examined the relation between a mother's exposure to maternal genital / reproductive infections during the period from before conception to early pregnancy, and schizophrenia in offspring, and followed 7,794 offspring of pregnancies with prospectively acquired data on maternal genital / reproductive infections from obstetric records. (schizophrenia.com)
  • In this study, we hypothesized that exposure to maternal HF diet during pregnancy through weaning would produce long-lasting effects on the offspring liver and may induce an inflammatory response in addition to steatosis noted earlier in third-trimester fetuses. (diabetesjournals.org)
  • Only one human study investigated aflatoxin exposure and prematurity, and no studies investigated its relationship with pregnancy loss, but animal studies suggest aflatoxin exposure may increase risk for prematurity and pregnancy loss. (ajtmh.org)
  • This study was supported, in part, by the Agency for Toxic Substances and Disease Registry and the Centers for Disease Control and Prevention through a cooperative agreement grant to NYSDOH titled "Program to Conduct and Coordinate Site-Specific Activities" (U50/ATU200002) and by New York State's Maternal and Child Health Services (MCH) block grant through the NYSDOH Maternal and Child Health Graduate Assistant Program. (nih.gov)
  • This study provides further evidence of an association between exposure to solvents during pregnancy and the risk of major malformations. (bmj.com)
  • hence the aim of the present study was to assess renal function in young (4-week-old) rats exposed in the uterus to a maternal low-protein diet. (portlandpress.com)
  • ii) a biomarker study on 51 mother-child pairs for whom recent maternal plasma dioxin measurements were available. (plos.org)
  • The induction of inherited DNA sequence mutations arising in the germline (i.e., sperm or egg) of mice exposed in utero to diesel exhaust particles (DEPs) via maternal inhalation compared to unexposed controls was investigated in this study. (ruc.dk)
  • The present study used family stress theory as a framework to study the impact of proximal (i.e., family structure, maternal depression) and distal (i.e., community violence) risk factors, or stressors, on parenting characteristics which were in turn hypothesized to impact child social-emotional functioning. (umd.edu)
  • The present study hypothesized that exposure to violence, family structure, maternal depression, and parenting styles measured at time 1 would affect child social-emotional functioning at time 2. (umd.edu)
  • This study aimed to assess the relationship between birth weight and maternal exposure to passive smoking during pregnancy, and to investigate some other determinants of birth weight. (who.int)
  • This study examined the effects of lactational dexamethasone exposure on metabolic imbalance and oxidative stress marker in the liver of male offspring of exposed mother. (ajol.info)
  • A case-control study was conducted in Italy to investigate the association between childhood neuroblastoma and exposure to extremely low frequency magnetic fields as well as other risk factors . (emf-portal.org)
  • From the data generated in this study, it was evident that maternal nicotine exposure during pregnancy and lactation increased blood pressure of male offspring but not female offspring. (uwc.ac.za)
  • Objective: This study aimed to assess the relative contribution of exposure to a maternal cafeteria diet during pregnancy and lactation on body weight, fat mass and expression of lipogenic and adipokine genes in the offspring. (nottingham.ac.uk)
  • Messiha FS (1988) Maternal cesium chloride ingestion and the newborn. (springer.com)
  • Maternal antibodies against IPAs expressed on red blood cells (RBC) such as Rh and K antigens, can cause severe hemolytic disease of the fetus and newborn (HDFN). (haematologica.org)
  • Correlation between DNA adduct levels/10 8 nucleotides in paired maternal and newborn WBCs. (aacrjournals.org)
  • Correlation between plasma cotinine levels (ng/ml) in paired maternal and newborn blood samples. (aacrjournals.org)
  • d Newborn adduct levels = maternal adduct levels. (aacrjournals.org)
  • Higher MDS-P score, folic acid supplementation, and greater in utero exposure to endosulfan-diol and endosulfan-1 were related to higher newborn weight. (diva-portal.org)
  • P04.6 should be used on the newborn record - not on the maternal record. (icd10data.com)
  • A series of related studies on mutation at the X-linked HPRT locus in human newborn cord blood samples has led to the novel conclusion that only passive maternal exposure to tobacco mutagens has a significant effect on the developing baby. (biomedcentral.com)
  • OBJECTIVE: To estimate the effects of cocaine exposure on intrauterine growth and to investigate at what point in gestation growth deviation would be manifested. (rti.org)
  • After controlling for confounders, at 40 weeks' gestation, cocaine exposure was estimated to be associated with a decrease of 151 g, 0.71 cm, and 0.43 cm in birth weight, length, and head circumference, respectively. (rti.org)
  • CONCLUSION: In utero cocaine exposure is associated with growth deceleration involving all measurements, becoming more pronounced with advancing gestation. (rti.org)
  • Abortion may occur if maternal infection occurs before 20 weeks of gestation. (safefetus.com)
  • Notably, serotonin reuptake inhibitors (SRIs) are antidepressant agents increasingly prescribed to manage antenatal mood disorders, and depressed maternal mood per se during pregnancy impacts infant behavior, also raising concerns about long-term consequences following such developmental exposure. (pnas.org)
  • Thus, prenatal depressed maternal mood and SRI exposure were found to shift developmental milestones bidirectionally on infant speech perception tasks. (pnas.org)
  • These factors may be associated with reductions in both calcium and zinc in maternal serum and the fetus, and both the placenta and embryos may be major targets of developmental toxicity following maternal exposure to nano-TiO 2 during the prenatal period. (dovepress.com)
  • 4-7 To focus efforts on reducing these toxic exposures, a group of expert toxicologists, health professionals, and patient advocates called Project TENDR (Targeting Environmental Neuro-Developmental Risk) developed consensus on highlighting six prime examples. (contemporaryobgyn.net)
  • Multinomial logistic regression analyses were used to examine unadjusted and adjusted associations between these physical and mental health exposures and child developmental vulnerabilities at age 5 years. (ovid.com)
  • maternal noninfectious illness during pregnancy also retained small but significant associations with developmental vulnerabilities even when adjusted for other physical and mental illness exposures and covariates known to be associated with early childhood development (e.g., child's sex, socioeconomic disadvantage, young maternal age, prenatal smoking). (ovid.com)
  • Among all exposures examined, maternal mental illness first diagnosed prior to childbirth conferred the greatest odds of developmental vulnerability at age 5 years. (ovid.com)
  • Prenatal exposure to infectious or noninfectious diseases appear to influence early childhood physical, social, emotional and cognitive developmental vulnerabilities that may represent intermediate phenotypes for subsequent mental disorders. (ovid.com)
  • We assessed the modifying effects of maternal PON1 -108 C/T and PON1 192 Q/R genotypes on relationships between prenatal OP exposure and developmental quotients (DQs) in 24-month-old children in Shandong, China ( n = 172). (springer.com)
  • There is also new evidence that developmental exposures to tobacco smoke may be associated with reproductive effects in adulthood. (eurekaselect.com)
  • Altogether, these data show that early exposure to post-accidental doses of 137 Cs induces the alteration of vitamin D metabolism, associated with a dysregulation of mineral homeostasis. (springer.com)
  • After accounting for factors associated with fluoride metabolism and children's intellectual abilities, a 1-mg/L increase in maternal urinary fluoride was associated with a 4.5-point lower IQ score in boys without a statistically significant association with IQ score in girls. (medindia.net)
  • However, rodent studies are limited in their ability to explain whether and how differences in maternal metabolism and intrauterine exposures may affect human development. (diabetesjournals.org)
  • Paraoxonase 1 (PON1) is a key enzyme in the metabolism of OPs and may affect an individual's susceptibility to OP exposure. (springer.com)
  • A mother's exposure to genital/reproductive infections during the period from before conception to early pregnancy was associated with a significantly increased (approximately 500% greater) risk of schizophrenia and other schizophrenia spectrum disorders, with adjustment for maternal race, education, age, and mental illness. (schizophrenia.com)
  • Maternal genital/reproductive infection during conception and early pregnancy appears to increase the risk of schizophrenia in offspring. (schizophrenia.com)
  • Likewise, an entry posted on the American Cancer Society website shows that long-term exposure to the harmful chemical is associated with an increased risk of anemia, low white blood cell count, and low platelet count as well as reproductive and fertility conditions. (naturalnews.com)
  • Highlights Maternal exposure to DEHP transgenerationally affects female reproductive health. (ovid.com)
  • Maternal exposure to estrogenic xenobiotics or phthalates has been implicated in the distortion of early male reproductive development, referred to in humans as the testicular dysgenesis syndrome. (nottingham.ac.uk)
  • Background: Reported rises in the prevalence of hypospadias and other abnormalities of the male reproductive system may be a result of exposure to endocrine disrupting chemicals. (manchester.ac.uk)
  • Secondhand tobacco smoke (STS) contains a number of known or suspected reproductive toxins, and human exposure to STS is prevalent worldwide. (eurekaselect.com)
  • Results of maternal HIV testing should be documented in the newborn's medical record and communicated to the newborn's primary care provider (AIII) . (nih.gov)
  • The results will enable clinicians to prospectively calculate individual dosing regimens for the mother in order to optimize dosing and limit unnecessary drug exposure to the child. (clinicaltrials.gov)
  • RESULTS: Triclosan was detected in over 80% of the maternal urines (geometric mean (GM): 21.61μg/L), 60% of the infant urines (GM: 2.8μg/L), 46% of the breast milk and 80% of the meconium samples. (biomedsearch.com)
  • Our results suggest that PCB exposure may result in a shift toward the production of more glia and fewer neurons in the early cortex. (epa.gov)
  • These results suggest that this neuronal CCL2/CCR2 system closely linked to MCH neurons has a role in mediating the effects of maternal ethanol exposure on adolescent offspring and contributes to the higher levels of adolescent risk factors for alcohol use disorders described in women. (jneurosci.org)
  • BackgroundPrenatal programming by maternal dietary protein deprivation and prenatal dexamethasone result in a reduction in nephron number and hypertension when the offspring are studied as adults.MethodsTo determine whether prenatal dietary protein deprivation results in a reduction in nephron. (ebscohost.com)
  • These results improve our understanding of maternal transfer and sublethal effects of brevetoxin exposure in marine turtles. (ucsd.edu)
  • Thus, maternal exposure to DEP results in increased mutation in sperm during development. (ruc.dk)
  • These results indicate prenatal exposure to OCPs in Southern Spain and its possible impact on the weight of healthy full-term newborns. (diva-portal.org)
  • Results: Maternal exposure to PM impaired somatic growth of male offspring resulting in reduced lung volume and deficits in lung function. (edu.au)
  • Urinary sexual steroids associated with bisphenol A (BPA) exposure in the early infant stage: Preliminary results from a Daishan birth cohort. (semanticscholar.org)
  • Taken together, these results support the notion that maternal exposure to certain xenobiotics can also influence the development of the adult-type Leydig cell population, possibly through an effect on the Leydig stem cell population. (nottingham.ac.uk)
  • Previous studies attempting to establish a direct link between active smoking and levels of somatic mutation have largely discounted the effects of passive or secondary exposure, and have produced contradictory results. (biomedcentral.com)
  • Our results suggest a synergistic effect of prenatal infection and adolescent cannabinoid exposure on the integrity of the serotoninergic system in the hippocampus that may provide the neurochemical substrate for abnormal hippocampal-related functions relevant to schizophrenia. (tcd.ie)
  • Results: Five individual occupations (of 348) showed nominally statistically significant excesses, none of which had possible or probable exposure to potential EDCs. (manchester.ac.uk)
  • Are there any toxic exposures linked to child onset type 2 diabetes? (healthtap.com)
  • These six toxic exposures (Table 1) include chemicals widely used in consumer products, those present in the home setting, and broad public space exposures. (contemporaryobgyn.net)
  • Maternal and infant exposure to environmental phenols as measured in multiple biological matrices. (biomedsearch.com)
  • Pregnant women and their developing fetuses are vulnerable to multiple environmental insults, including exposure to aflatoxin, a mycotoxin that may contaminate as much as 25% of the world food supply. (ajtmh.org)
  • Environmental mold, or healthcare exposure? (healthtap.com)
  • Two exposure areas were identified based on environmental sampling data: one area was primarily contaminated with TCE, and the other with PCE. (nih.gov)
  • 5 7 The aetiology of PROM has been shown to be multifactorial, and increasing evidence has regarded exposure to environmental pollutants as risk factors for PROM. (bmj.com)
  • Ob/gyns and all women's health providers should become facile on environmental health risk assessment, exposure reduction, and feasible clinical counseling. (contemporaryobgyn.net)
  • Before delving into types of environmental exposures, it is important to consider the vital role of women's health providers in protecting pregnancies from harm. (contemporaryobgyn.net)
  • Where possible, passive exposure to environmental tobacco smoke was considered as a separate category of exposure, rather than being included in the non-smoking controls. (biomedcentral.com)
  • Environmental tobacco smoke (ETS) exposure has a clinically significant, detrimental impact on public health [ 1 , 2 ] and so is an important issue for policy makers and clinicians. (biomedcentral.com)
  • We demonstrate that maternal administration of ethanol (2 g/kg/d) from embryonic day 10 (E10) to E15, while having little impact on glia, stimulates expression of neuronal CCL2 and CCR2, increases density of both large CCL2 neurons colocalizing MCH and small CCL2 neurons surrounding MCH neurons, and stimulates ethanol drinking and anxiety in adolescent offspring. (jneurosci.org)
  • We demonstrate in adolescent offspring that maternal administration of CCL2, like ethanol, stimulates these neurons and increases ethanol drinking and anxiety, and these effects of ethanol are blocked by maternal CCR2 antagonist and consistently stronger in females. (jneurosci.org)
  • As maternal age increases, risks of birth defects increase. (wikibooks.org)
  • Our analysis reveals a more commonsensical, yet no less cautionary result: both active maternal smoking and secondary maternal exposure produce quantitatively and qualitatively indistinguishable increases in fetal HPRT mutation. (biomedcentral.com)
  • Odds ratios for "possible" or "probable" compared to "unlikely" exposure to potential EDCs did not show statistically significant increases in any of the EDC categories after adjustment for social class of the mother and father, nor was there evidence of an upward trend in risk with likelihood of exposure. (manchester.ac.uk)
  • To address this issue, we have begun modeling adolescent opiate exposure in female rats and have observed significant transgenerational effects despite the fact that all drugs are withdrawn several weeks prior to pregnancy. (frontiersin.org)
  • Recent studies have proposed a link between impaired nephrogenesis, decreased activity of the renin-angiotensin system and the onset of hypertension in rats exposed in the uterus to a maternal low-protein diet. (portlandpress.com)
  • Maternal nicotine exposure during pregnancy and lactation leads to alteration in aorta structure as evaluated by H and E staining. (uwc.ac.za)
  • Maternal urinary Pb level was adjusted by creatinine concentration, and its relationship with PROM was analysed by logistic regression. (bmj.com)
  • High exposure to benzene during pregnancy is associated with low birth weight, an increased risk of childhood leukemia, and a greater incidence of birth defects such as spina bifida. (naturalnews.com)
  • So, researchers - many from York University, in Toronto, Canada - have wondered whether a mother's exposure to fluoridated tap water during pregnancy affects her offspring's intelligence scores. (medicalnewstoday.com)
  • The cellular and molecular mechanisms by which maternal opioid exposure affects brain development, including neuronal differentiation, migration, synaptic formation and neural circuit activities. (cloudfront.net)
  • The sexual dimorphism in response to the maternal environment coupled with changes in placental gene expression may explain aberrations in phenotype observed in offspring derived from obese females. (biomedcentral.com)
  • WEDNESDAY, June 13, 2018 -- Exposure to hypertensive disorders of pregnancy (HDP) may be associated with an increase in the risk of autism spectrum disorder (ASD) and attention deficit/hyperactivity disorder (ADHD) in offspring, according to a review published online June 6 in JAMA Psychiatry . (drugs.com)
  • A maternal diabetic intrauterine environment has consequences for future type 2 diabetes risk in the offspring ( 2 ). (diabetesjournals.org)
  • WEDNESDAY, June 13, 2018 (HealthDay News) -- Exposure to hypertensive disorders of pregnancy (HDP) may be associated with an increase in the risk of autism spectrum disorder (ASD) and attention deficit/hyperactivity disorder (ADHD) in offspring, according to a review published online June 6 in JAMA Psychiatry . (doctorslounge.com)
  • Maternal exposure to dietary factors during pregnancy influences the risk of many adult-onset diseases in the later life of offspring. (rsc.org)
  • In conclusion, maternal exposure to a high-fat diet rich in n-3 PUFAs, both marine- and plant-based, has a protective effect on mammary tumor risk of female offspring in later life. (rsc.org)
  • This suggests that neuronal chemokine signaling linked to neuropeptides mediates effects of maternal ethanol exposure on adolescent offspring and contributes to higher levels of adolescent risk factors for alcohol use disorders in women. (jneurosci.org)
  • We examined the relationship between intrauterine dichlorodiphenyltrichloroethane (DDT) exposure (o,p'-DDT, p,p'-DDT, and p,p'-DDE) and mammographic breast density (MBD) in midlife, one of the strongest risk factors for breast cancer. (medworm.com)
  • We focused our analyses on o,p'-DDT exposure given our previous report of a positive association between intrauterine o,p'-DDT exposure and daughter's breast cancer (BC) risk. (medworm.com)
  • Advanced maternal age begins at 35 years of age because a woman's risk of having a child with a chromosomal difference at 35 is equal to the risk of having a miscarriage via an amniocentesis (both risks are equal to 1 in 200). (wikibooks.org)
  • Mineral dust exposure was associated with increased risk of coarctation of aorta (OR adj 2.94, 95% CI 1.21-7.13) and pulmonary valve stenosis (OR adj 1.99, 95% CI 1.10-3.62). (sjweh.fi)
  • Recent studies suggest maternal air pollution exposure as a potential risk factor. (unc.edu)
  • OBJECTIVES To determine whether maternal exposure to high levels of MF nonionizing radiation is associated with an increased risk of ADHD in offspring by using more accurate measurements of MF nonionizing radiation levels and physician-diagnosed ADHD, rather than self-reports, and to determine whether the association differs for the subtypes of ADHD with or without immune-related comorbidities. (avaate.org)
  • conversely maternal underweight was associated with increased risk of delivering an LBW infant. (biomedcentral.com)
  • Maternal immune activation (MIA) leading to in utero inflammation has been proposed to be a risk factor for these disorders, yet it is unclear how this stimulus can lead to the diverse disturbances in dopaminergic-driven behaviors that emerge at different stages of life in affected offspring. (drugsandalcohol.ie)
  • Aims: To analyse the relation between risk of hypospadias and maternal occupation, particularly with regard to exposure to potential endocrine disrupting chemicals (EDCs). (manchester.ac.uk)
  • We sought to extend this literature using interview data combined with detailed exposure assessment. (cdc.gov)
  • This report summarizes the OEEB's investigation and assessment of the pesticide exposures likely experienced by these women while in North Carolina. (migrantclinician.org)
  • The fetus could be affected by maternal aflatoxin exposure through direct toxicity as well as indirect toxicity, via maternal systemic inflammation, impaired placental growth, or elevation of placental cytokines. (ajtmh.org)
  • Accumulating evidence suggests that prenatal exposure to infection contributes to the causal factors [etiology] of schizophrenia. (schizophrenia.com)
  • It is becoming increasingly clear that fetal nicotine exposure, through transfer of nicotine via the placenta, has numerous consequences that is detrimental to the health of the fetus and that these effects may last into adulthood or perhaps even manifest itself later in life. (uwc.ac.za)
  • Dietary fat alters body composition, mammary development, and cytochrome p450 induction after maternal TCDD exposure in DBA/2J mice with low-responsive aryl hydrocarbon receptors. (nih.gov)
  • 6 micrograms/l) was detected in either maternal or umbilical serum in 300 pregnancies, and these mothers and newborns were classified as exposed. (nih.gov)
  • The smoking habit reported by mothers themselves is not an accurate measure of fetal tobacco exposure. (nih.gov)
  • The way in which mothers regulate their children's sun exposure may be affected by being TD. (springer.com)
  • Associations between 17 TD related SNPs in children and their mothers and 10 sun exposure variables in children (assessed via questionnaire at age 8) were analyzed in logistic and ordinal logistic regressions. (springer.com)
  • ETS contains lower doses of the same toxins that smokers inhale [ 1 ], so maternal ETS exposure during pregnancy should have similar but less severe effects. (biomedcentral.com)
  • The objective of this research project was to test the hypothesis that combined exposure to nicotine and chlorpyrifos (CPF) during the critical periods of development of cholinergic pathways in the central nervous system disrupts the structural organization of the cholinergic system and interferes with the cholinergic transmission, resulting in neurologic deficits such as impairments in learning and memory performance. (epa.gov)
  • Green and colleagues explain the motivation for their research, saying that while previous observational studies have found a link between drinking fluoridated water and reduced child IQ scores, these studies did not assess "exposure during fetal brain development. (medicalnewstoday.com)