The age of the mother in PREGNANCY.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
Age of the biological father.
A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)
The sequence in which children are born into the family.
Pregnancy in which the mother and/or FETUS are at greater than normal risk of MORBIDITY or MORTALITY. Causes include inadequate PRENATAL CARE, previous obstetrical history (ABORTION, SPONTANEOUS), pre-existing maternal disease, pregnancy-induced disease (GESTATIONAL HYPERTENSION), and MULTIPLE PREGNANCY, as well as advanced maternal age above 35.
An infant during the first month after birth.
Percutaneous transabdominal puncture of the uterus during pregnancy to obtain amniotic fluid. It is commonly used for fetal karyotype determination in order to diagnose abnormal fetal conditions.
The number of offspring a female has borne. It is contrasted with GRAVIDITY, which refers to the number of pregnancies, regardless of outcome.
Results of conception and ensuing pregnancy, including LIVE BIRTH; STILLBIRTH; SPONTANEOUS ABORTION; INDUCED ABORTION. The outcome may follow natural or artificial insemination or any of the various ASSISTED REPRODUCTIVE TECHNIQUES, such as EMBRYO TRANSFER or FERTILIZATION IN VITRO.
The mass or quantity of heaviness of an individual at BIRTH. It is expressed by units of pounds or kilograms.
The age of the conceptus, beginning from the time of FERTILIZATION. In clinical obstetrics, the gestational age is often estimated as the time from the last day of the last MENSTRUATION which is about 2 weeks before OVULATION and fertilization.
Determination of the nature of a pathological condition or disease in the postimplantation EMBRYO; FETUS; or pregnant female before birth.
The possession of a third chromosome of any one type in an otherwise diploid cell.
The beginning third of a human PREGNANCY, from the first day of the last normal menstrual period (MENSTRUATION) through the completion of 14 weeks (98 days) of gestation.
Conditions or pathological processes associated with pregnancy. They can occur during or after pregnancy, and range from minor discomforts to serious diseases that require medical interventions. They include diseases in pregnant females, and pregnancies in females with diseases.
Malformations of organs or body parts during development in utero.
The failure of homologous CHROMOSOMES or CHROMATIDS to segregate during MITOSIS or MEIOSIS with the result that one daughter cell has both of a pair of parental chromosomes or chromatids and the other has none.
Expulsion of the product of FERTILIZATION before completing the term of GESTATION and without deliberate interference.
Official certifications by a physician recording the individual's birth date, place of birth, parentage and other required identifying data which are filed with the local registrar of vital statistics.
In utero measurement corresponding to the sitting height (crown to rump) of the fetus. Length is considered a more accurate criterion of the age of the fetus than is the weight. The average crown-rump length of the fetus at term is 36 cm. (From Williams Obstetrics, 18th ed, p91)
A prenatal ultrasonography measurement of the soft tissue behind the fetal neck. Either the translucent area below the skin in the back of the fetal neck (nuchal translucency) or the distance between occipital bone to the outer skin line (nuchal fold) is measured.
The chromosomal constitution of cells which deviate from the normal by the addition or subtraction of CHROMOSOMES, chromosome pairs, or chromosome fragments. In a normally diploid cell (DIPLOIDY) the loss of a chromosome pair is termed nullisomy (symbol: 2N-2), the loss of a single chromosome is MONOSOMY (symbol: 2N-1), the addition of a chromosome pair is tetrasomy (symbol: 2N+2), the addition of a single chromosome is TRISOMY (symbol: 2N+1).
Clinical conditions caused by an abnormal chromosome constitution in which there is extra or missing chromosome material (either a whole chromosome or a chromosome segment). (from Thompson et al., Genetics in Medicine, 5th ed, p429)
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Extraction of the FETUS by means of abdominal HYSTEROTOMY.
The middle third of a human PREGNANCY, from the beginning of the 15th through the 28th completed week (99 to 196 days) of gestation.
An infant having a birth weight of 2500 gm. (5.5 lb.) or less but INFANT, VERY LOW BIRTH WEIGHT is available for infants having a birth weight of 1500 grams (3.3 lb.) or less.
The visualization of tissues during pregnancy through recording of the echoes of ultrasonic waves directed into the body. The procedure may be applied with reference to the mother or the fetus and with reference to organs or the detection of maternal or fetal disease.
Postnatal deaths from BIRTH to 365 days after birth in a given population. Postneonatal mortality represents deaths between 28 days and 365 days after birth (as defined by National Center for Health Statistics). Neonatal mortality represents deaths from birth to 27 days after birth.
The beta subunit of human CHORIONIC GONADOTROPIN. Its structure is similar to the beta subunit of LUTEINIZING HORMONE, except for the additional 30 amino acids at the carboxy end with the associated carbohydrate residues. HCG-beta is used as a diagnostic marker for early detection of pregnancy, spontaneous abortion (ABORTION, SPONTANEOUS); ECTOPIC PREGNANCY; HYDATIDIFORM MOLE; CHORIOCARCINOMA; or DOWN SYNDROME.
The condition of carrying two or more FETUSES simultaneously.
Death of the developing young in utero. BIRTH of a dead FETUS is STILLBIRTH.
CHILDBIRTH before 37 weeks of PREGNANCY (259 days from the first day of the mother's last menstrual period, or 245 days after FERTILIZATION).
Female parents, human or animal.
A product of the PLACENTA, and DECIDUA, secreted into the maternal circulation during PREGNANCY. It has been identified as an IGF binding protein (IGFBP)-4 protease that proteolyzes IGFBP-4 and thus increases IGF bioavailability. It is found also in human FIBROBLASTS, ovarian FOLLICULAR FLUID, and GRANULOSA CELLS. The enzyme is a heterotetramer of about 500-kDa.
A HERNIA due to an imperfect closure or weakness of the umbilical ring. It appears as a skin-covered protrusion at the UMBILICUS during crying, coughing, or straining. The hernia generally consists of OMENTUM or SMALL INTESTINE. The vast majority of umbilical hernias are congenital but can be acquired due to severe abdominal distention.
A congenital defect with major fissure in the ABDOMINAL WALL lateral to, but not at, the UMBILICUS. This results in the extrusion of VISCERA. Unlike OMPHALOCELE, herniated structures in gastroschisis are not covered by a sac or PERITONEUM.
Determination of the nature of a pathological condition or disease in the OVUM; ZYGOTE; or BLASTOCYST prior to implantation. CYTOGENETIC ANALYSIS is performed to determine the presence or absence of genetic disease.
Care provided the pregnant woman in order to prevent complications, and decrease the incidence of maternal and prenatal mortality.
An assisted reproductive technique that includes the direct handling and manipulation of oocytes and sperm to achieve fertilization in vitro.
The event that a FETUS is born alive with heartbeats or RESPIRATION regardless of GESTATIONAL AGE. Such liveborn is called a newborn infant (INFANT, NEWBORN).
The event that a FETUS is born dead or stillborn.
Deaths occurring from the 28th week of GESTATION to the 28th day after birth in a given population.
The lengths of intervals between births to women in the population.
Clinical and laboratory techniques used to enhance fertility in humans and animals.
An infant having a birth weight lower than expected for its gestational age.
Pathophysiological conditions of the FETUS in the UTERUS. Some fetal diseases may be treated with FETAL THERAPIES.
Abortion performed because of possible fetal defects.
Pregnancy in human adolescent females under the age of 19.
Abnormal number or structure of chromosomes. Chromosome aberrations may result in CHROMOSOME DISORDERS.
Minute cells produced during development of an OOCYTE as it undergoes MEIOSIS. A polar body contains one of the nuclei derived from the first or second meiotic CELL DIVISION. Polar bodies have practically no CYTOPLASM. They are eventually discarded by the oocyte. (from King & Stansfield, A Dictionary of Genetics, 4th ed)
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
Delivery of the FETUS and PLACENTA under the care of an obstetrician or a health worker. Obstetric deliveries may involve physical, psychological, medical, or surgical interventions.
The number of births in a given population per year or other unit of time.
A specific pair of GROUP G CHROMOSOMES of the human chromosome classification.
A method for diagnosis of fetal diseases by sampling the cells of the placental chorionic villi for DNA analysis, presence of bacteria, concentration of metabolites, etc. The advantage over amniocentesis is that the procedure can be carried out in the first trimester.
Medical problems associated with OBSTETRIC LABOR, such as BREECH PRESENTATION; PREMATURE OBSTETRIC LABOR; HEMORRHAGE; or others. These complications can affect the well-being of the mother, the FETUS, or both.
Two individuals derived from two FETUSES that were fertilized at or about the same time, developed in the UTERUS simultaneously, and born to the same mother. Twins are either monozygotic (TWINS, MONOZYGOTIC) or dizygotic (TWINS, DIZYGOTIC).
Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.
A specific pair of GROUP E CHROMOSOMES of the human chromosome classification.
The short, acrocentric human chromosomes, called group G in the human chromosome classification. This group consists of chromosome pairs 21 and 22 and the Y chromosome.
A demographic parameter indicating a person's status with respect to marriage, divorce, widowhood, singleness, etc.
Mapping of the KARYOTYPE of a cell.
The ratio of two odds. The exposure-odds ratio for case control data is the ratio of the odds in favor of exposure among cases to the odds in favor of exposure among noncases. The disease-odds ratio for a cohort or cross section is the ratio of the odds in favor of disease among the exposed to the odds in favor of disease among the unexposed. The prevalence-odds ratio refers to an odds ratio derived cross-sectionally from studies of prevalent cases.
The part of a human or animal body connecting the HEAD to the rest of the body.
The consequences of exposing the FETUS in utero to certain factors, such as NUTRITION PHYSIOLOGICAL PHENOMENA; PHYSIOLOGICAL STRESS; DRUGS; RADIATION; and other physical or chemical factors. These consequences are observed later in the offspring after BIRTH.
The systems and processes involved in the establishment, support, management, and operation of registers, e.g., disease registers.
Social and economic factors that characterize the individual or group within the social structure.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
The number of males per 100 females.
The nursing of an infant at the breast.
A specific pair of GROUP D CHROMOSOMES of the human chromosome classification.
Exposure of the female parent, human or animal, to potentially harmful chemical, physical, or biological agents in the environment or to environmental factors that may include ionizing radiation, pathogenic organisms, or toxic chemicals that may affect offspring. It includes pre-conception maternal exposure.
Onset of OBSTETRIC LABOR before term (TERM BIRTH) but usually after the FETUS has become viable. In humans, it occurs sometime during the 29th through 38th week of PREGNANCY. TOCOLYSIS inhibits premature labor and can prevent the BIRTH of premature infants (INFANT, PREMATURE).
A complication of PREGNANCY, characterized by a complex of symptoms including maternal HYPERTENSION and PROTEINURIA with or without pathological EDEMA. Symptoms may range between mild and severe. Pre-eclampsia usually occurs after the 20th week of gestation, but may develop before this time in the presence of trophoblastic disease.
An assisted fertilization technique consisting of the microinjection of a single viable sperm into an extracted ovum. It is used principally to overcome low sperm count, low sperm motility, inability of sperm to penetrate the egg, or other conditions related to male infertility (INFERTILITY, MALE).
Either one of the two small elongated rectangular bones that together form the bridge of the nose.
Diabetes mellitus induced by PREGNANCY but resolved at the end of pregnancy. It does not include previously diagnosed diabetics who become pregnant (PREGNANCY IN DIABETICS). Gestational diabetes usually develops in late pregnancy when insulin antagonistic hormones peaks leading to INSULIN RESISTANCE; GLUCOSE INTOLERANCE; and HYPERGLYCEMIA.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Educational attainment or level of education of individuals.
The transfer of mammalian embryos from an in vivo or in vitro environment to a suitable host to improve pregnancy or gestational outcome in human or animal. In human fertility treatment programs, preimplantation embryos ranging from the 4-cell stage to the blastocyst stage are transferred to the uterine cavity between 3-5 days after FERTILIZATION IN VITRO.
Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.
The probability that an event will occur. It encompasses a variety of measures of the probability of a generally unfavorable outcome.
Three or more consecutive spontaneous abortions.
The number of pregnancies, complete or incomplete, experienced by a female. It is different from PARITY, which is the number of offspring borne. (From Stedman, 26th ed)
A condition of fetal overgrowth leading to a large-for-gestational-age FETUS. It is defined as BIRTH WEIGHT greater than 4,000 grams or above the 90th percentile for population and sex-specific growth curves. It is commonly seen in GESTATIONAL DIABETES; PROLONGED PREGNANCY; and pregnancies complicated by pre-existing diabetes mellitus.
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
The last third of a human PREGNANCY, from the beginning of the 29th through the 42nd completed week (197 to 294 days) of gestation.
The condition of carrying TWINS simultaneously.
The offspring in multiple pregnancies (PREGNANCY, MULTIPLE): TWINS; TRIPLETS; QUADRUPLETS; QUINTUPLETS; etc.
A stratum of people with similar position and prestige; includes social stratification. Social class is measured by criteria such as education, occupation, and income.
A condition in pregnant women with elevated systolic (>140 mm Hg) and diastolic (>90 mm Hg) blood pressure on at least two occasions 6 h apart. HYPERTENSION complicates 8-10% of all pregnancies, generally after 20 weeks of gestation. Gestational hypertension can be divided into several broad categories according to the complexity and associated symptoms, such as EDEMA; PROTEINURIA; SEIZURES; abnormalities in BLOOD COAGULATION and liver functions.
The failure of a FETUS to attain its expected FETAL GROWTH at any GESTATIONAL AGE.
A hydroxylated metabolite of ESTRADIOL or ESTRONE that has a hydroxyl group at C3, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During PREGNANCY, a large amount of estriol is produced by the PLACENTA. Isomers with inversion of the hydroxyl group or groups are called epiestriol.
A type of CELL NUCLEUS division, occurring during maturation of the GERM CELLS. Two successive cell nucleus divisions following a single chromosome duplication (S PHASE) result in daughter cells with half the number of CHROMOSOMES as the parent cells.
The care of women and a fetus or newborn given before, during, and after delivery from the 28th week of gestation through the 7th day after delivery.
A method, developed by Dr. Virginia Apgar, to evaluate a newborn's adjustment to extrauterine life. Five items - heart rate, respiratory effort, muscle tone, reflex irritability, and color - are evaluated 60 seconds after birth and again five minutes later on a scale from 0-2, 0 being the lowest, 2 being normal. The five numbers are added for the Apgar score. A score of 0-3 represents severe distress, 4-7 indicates moderate distress, and a score of 7-10 predicts an absence of difficulty in adjusting to extrauterine life.
The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.
Inability to reproduce after a specified period of unprotected intercourse. Reproductive sterility is permanent infertility.
Intentional removal of a fetus from the uterus by any of a number of techniques. (POPLINE, 1978)
The abrupt and unexplained death of an apparently healthy infant under one year of age, remaining unexplained after a thorough case investigation, including performance of a complete autopsy, examination of the death scene, and review of the clinical history. (Pediatr Pathol 1991 Sep-Oct;11(5):677-84)
Three individuals derived from three FETUSES that were fertilized at or about the same time, developed in the UTERUS simultaneously, and born to the same mother.
Human females who are pregnant, as cultural, psychological, or sociological entities.
The process of giving birth to one or more offspring.
Artificially induced UTERINE CONTRACTION. Generally, LABOR, OBSTETRIC is induced with the intent to cause delivery of the fetus and termination of pregnancy.
A human infant born before 37 weeks of GESTATION.
Inhaling and exhaling the smoke of burning TOBACCO.
The capacity to conceive or to induce conception. It may refer to either the male or female.
The short, metacentric human chromosomes, called group F in the human chromosome classification. This group consists of chromosome pairs 19 and 20.
A malformation of the nervous system caused by failure of the anterior neuropore to close. Infants are born with intact spinal cords, cerebellums, and brainstems, but lack formation of neural structures above this level. The skull is only partially formed but the eyes are usually normal. This condition may be associated with folate deficiency. Affected infants are only capable of primitive (brain stem) reflexes and usually do not survive for more than two weeks. (From Menkes, Textbook of Child Neurology, 5th ed, p247)
Abnormal number or structure of the SEX CHROMOSOMES. Some sex chromosome aberrations are associated with SEX CHROMOSOME DISORDERS and SEX CHROMOSOME DISORDERS OF SEX DEVELOPMENT.
The heart rate of the FETUS. The normal range at term is between 120 and 160 beats per minute.
The state of PREGNANCY in women with DIABETES MELLITUS. This does not include either symptomatic diabetes or GLUCOSE INTOLERANCE induced by pregnancy (DIABETES, GESTATIONAL) which resolves at the end of pregnancy.
Size and composition of the family.
Maternal deaths resulting from complications of pregnancy and childbirth in a given population.
The occurrence in an individual of two or more cell populations of different chromosomal constitutions, derived from a single ZYGOTE, as opposed to CHIMERISM in which the different cell populations are derived from more than one zygote.
Number of fetal deaths with stated or presumed gestation of 20 weeks or more in a given population. Late fetal mortality is death after of 28 weeks or more.
Organized efforts by communities or organizations to improve the health and well-being of infants.
The medium-sized, acrocentric human chromosomes, called group D in the human chromosome classification. This group consists of chromosome pairs 13, 14, and 15.
Female germ cells derived from OOGONIA and termed OOCYTES when they enter MEIOSIS. The primary oocytes begin meiosis but are arrested at the diplotene state until OVULATION at PUBERTY to give rise to haploid secondary oocytes or ova (OVUM).
Organized efforts by communities or organizations to improve the health and well-being of the mother.
Individuals whose ancestral origins are in the continent of Europe.
Diminished or absent ability of a female to achieve conception.
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
CHILDBIRTH at the end of a normal duration of PREGNANCY, between 37 to 40 weeks of gestation or about 280 days from the first day of the mother's last menstrual period.
The behavior patterns associated with or characteristic of a mother.
The state of birth outside of wedlock. It may refer to the offspring or the parents.
Children who have reached maturity or the legal age of majority.
Extraction of the fetus by means of obstetrical instruments.
The distance from the sole to the crown of the head with body standing on a flat surface and fully extended.
The unborn young of a viviparous mammal, in the postembryonic period, after the major structures have been outlined. In humans, the unborn young from the end of the eighth week after CONCEPTION until BIRTH, as distinguished from the earlier EMBRYO, MAMMALIAN.
Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.
Morphological and physiological development of FETUSES.
An important aggregate factor in epidemiological studies of women's health. The concept usually includes the number and timing of pregnancies and their outcomes, the incidence of breast feeding, and may include age of menarche and menopause, regularity of menstruation, fertility, gynecological or obstetric problems, or contraceptive usage.
Two offspring from the same PREGNANCY. They are from two OVA, fertilized at about the same time by two SPERMATOZOA. Such twins are genetically distinct and can be of different sexes.
Male parents, human or animal.
Persons or animals having at least one parent in common. (American College Dictionary, 3d ed)
The ratio of the number of conceptions (CONCEPTION) including LIVE BIRTH; STILLBIRTH; and fetal losses, to the mean number of females of reproductive age in a population during a set time period.
Groups of individuals whose putative ancestry is from native continental populations based on similarities in physical appearance.
Abnormal placentation in which the PLACENTA implants in the lower segment of the UTERUS (the zone of dilation) and may cover part or all of the opening of the CERVIX. It is often associated with serious antepartum bleeding and PREMATURE LABOR.
The co-occurrence of pregnancy and an INFECTION. The infection may precede or follow FERTILIZATION.
In females, the period that is shortly after giving birth (PARTURITION).
Detection of a MUTATION; GENOTYPE; KARYOTYPE; or specific ALLELES associated with genetic traits, heritable diseases, or predisposition to a disease, or that may lead to the disease in descendants. It includes prenatal genetic testing.
The first alpha-globulins to appear in mammalian sera during FETAL DEVELOPMENT and the dominant serum proteins in early embryonic life.
Individuals whose ancestral origins are in the continent of Africa.
A range of values for a variable of interest, e.g., a rate, constructed so that this range has a specified probability of including the true value of the variable.
An indicator of body density as determined by the relationship of BODY WEIGHT to BODY HEIGHT. BMI=weight (kg)/height squared (m2). BMI correlates with body fat (ADIPOSE TISSUE). Their relationship varies with age and gender. For adults, BMI falls into these categories: below 18.5 (underweight); 18.5-24.9 (normal); 25.0-29.9 (overweight); 30.0 and above (obese). (National Center for Health Statistics, Centers for Disease Control and Prevention)

Effect of the interval between pregnancies on perinatal outcomes. (1/2227)

BACKGROUND: A short interval between pregnancies has been associated with adverse perinatal outcomes. Whether that association is due to confounding by other risk factors, such as maternal age, socioeconomic status, and reproductive history, is unknown. METHODS: We evaluated the interpregnancy interval in relation to low birth weight, preterm birth, and small size for gestational age by analyzing data from the birth certificates of 173,205 singleton infants born alive to multiparous mothers in Utah from 1989 to 1996. RESULTS: Infants conceived 18 to 23 months after a previous live birth had the lowest risks of adverse perinatal outcomes; shorter and longer interpregnancy intervals were associated with higher risks. These associations persisted when the data were stratified according to and controlled for 16 biologic, sociodemographic, and behavioral risk factors. As compared with infants conceived 18 to 23 months after a live birth, infants conceived less than 6 months after a live birth had odds ratios of 1.4 (95 percent confidence interval, 1.3 to 1.6) for low birth weight, 1.4 (95 percent confidence interval, 1.3 to 1.5) for preterm birth, and 1.3 (95 percent confidence interval, 1.2 to 1.4) for small size for gestational age; infants conceived 120 months or more after a live birth had odds ratios of 2.0 (95 percent confidence interval, 1.7 to 2.4);1.5 (95 percent confidence interval, 1.3 to 1.7), and 1.8 (95 percent confidence interval, 1.6 to 2.0) for these three adverse outcomes, respectively, when we controlled for all 16 risk factors with logistic regression. CONCLUSIONS: The optimal interpregnancy interval for preventing adverse perinatal outcomes is 18 to 23 months.  (+info)

Maternal smoking and Down syndrome: the confounding effect of maternal age. (2/2227)

Inconsistent results have been reported from studies evaluating the association of maternal smoking with birth of a Down syndrome child. Control of known risk factors, particularly maternal age, has also varied across studies. By using a population-based case-control design (775 Down syndrome cases and 7,750 normal controls) and Washington State birth record data for 1984-1994, the authors examined this hypothesized association and found a crude odds ratio of 0.80 (95% confidence interval 0.65-0.98). Controlling for broad categories of maternal age (<35 years, > or =35 years), as described in prior studies, resulted in a negative association (odds ratio = 0.87, 95% confidence interval 0.71-1.07). However, controlling for exact year of maternal age in conjunction with race and parity resulted in no association (odds ratio = 1.00, 95% confidence interval 0.82-1.24). In this study, the prevalence of Down syndrome births increased with increasing maternal age, whereas among controls the reported prevalence of smoking during pregnancy decreased with increasing maternal age. There is a substantial potential for residual confounding by maternal age in studies of maternal smoking and Down syndrome. After adequately controlling for maternal age in this study, the authors found no clear relation between maternal smoking and the risk of Down syndrome.  (+info)

Energy intake, not energy output, is a determinant of body size in infants. (3/2227)

BACKGROUND: It has been proposed that the primary determinants of body weight at 1 y of age are genetic background, as represented by parental obesity, and low total energy expenditure. OBJECTIVE: The objective was to determine the relative contributions of genetic background and energy intake and expenditure as determinants of body weight at 1 y of age. DESIGN: Forty infants of obese and 38 infants of lean mothers, half boys and half girls, were assessed at 3 mo of age for 10 risk factors for obesity: sex, risk group (obese or nonobese mothers), maternal and paternal body mass index, body weight, feeding mode (breast, bottle, or both), 3-d energy intake, nutritive sucking behavior during a test meal, total energy expenditure, sleeping energy expenditure, and interactions among them. RESULTS: The only difference between risk groups at baseline was that the high-risk group sucked more vigorously during the test meal. Four measures accounted for 62% of the variability in weight at 12 mo: 3-mo weight (41%, P = 0.0001), nutritive sucking behavior (9%, P = 0.0002), 3-d food intake (8%, P = 0.0002), and male sex (3%, P = 0.05). Food intake and sucking behavior at 3 mo accounted for similar amounts of variability in weight-for-length, body fat, fat-free mass, and skinfold thickness at 12 mo. Contrary to expectations, neither total nor sleeping energy expenditure at 3 mo nor maternal obesity contributed to measures of body size at 12 mo. CONCLUSIONS: Energy intake contributes significantly to measures of body weight and composition at 1 y of age; parental obesity and energy expenditure do not.  (+info)

Breast cancer risk in monozygotic and dizygotic female twins: a 20-year population-based cohort study in Finland from 1976 to 1995. (4/2227)

This population-based study investigated the occurrence of breast cancer over a 20-year period in a cohort of monozygotic (MZ) and dizygotic (DZ) twins in Finland. Altogether, 13,176 female twins of known zygosity who were living in Finland at the end of 1975 were identified from the Finnish Twin Cohort Study and followed-up for cancer through the Finnish Cancer Registry for the years 1976-1995. Standardized incidence ratios (SIRs) were calculated, based on national cancer incidence rates. The relative risk of breast cancer for MZ twins compared to DZ twins was decreased [SIR(MZ)/SIR(DZ) ratio = 0.78; 95% confidence interval (CI), 0.58-1.0]; the decreased risk for MZ twins (SIR = 0.76; 95% CI, 0.58-1.0) accounted for this result, whereas the risk for DZ twins did not differ from the general population risk (SIR = 0.98; 95% CI, 0.84-1.1). There was no risk decrease among MZ twins in other cancers related to reproductive behavior; i.e., number of children and age at first birth seem not to explain the decreased risk of breast cancer. Our results, which are in line with earlier studies on the same topic, suggest that prenatal influences or postnatal behavioral factors may protect MZ female twins from breast cancer.  (+info)

A family study of coarctation of the aorta. (5/2227)

Families of 100 patients with coarctation of the aorta and 50 controls for age, sex, and social status were studied to assess the influence of genetic and environmental variables in the aetiology. A tendency to familial aggregation of the condition and other congenital heart defects compatible with multifactorial inheritance was discerned. Recurrence risk for sibs is approximately 1 in 200 for coarctation of the aorta, and 1% for any form of congenital heart defect. The heritability of coarctation is estimated at 58%. The tendency for other non-cardiac defects to occur in the patients with coarctation does not appear in their sibs and is not so pronounced as in some other congenital heart conditions. Of the several environmental variables examined, there was no definitive association with any other than season of birth, which implies a possible association with maternal infection; there is also a suggestion of a paternal age effect, but these require investigation in a prospective survey.  (+info)

Fertility patterns after appendicectomy: historical cohort study. (6/2227)

OBJECTIVE: To examine fertility patterns in women who had their appendix removed in childhood. DESIGN: Historical cohort study with computerised data and fertility data for this cohort and for an age matched cohort of women from the Swedish general population. The cohorts were followed to 1994. SETTING: General population. PARTICIPANTS: 9840 women who were under 15 years when they underwent appendicectomy between 1964 and 1983; 47 590 control women. MAIN OUTCOME MEASURES: Diagnoses at discharge. Distributions of age at birth of first child among women with perforated and non-perforated appendix and women who underwent appendicectomy but were found to have a normal appendix compared with control women by using survival analysis methods. Parity distributions at the latest update of the registry were also examined. RESULTS: Women with a history of perforated appendix had a similar rate of first birth as the control women (adjusted hazard ratio 0.95; 95% confidence interval 0.88 to 1. 04) and had a similar distribution of parity at the end of follow up. Women who had had a normal appendix removed had an increased rate of first births (1.48; 1.42 to 1.54) and on average had their first child at an earlier age and reached a higher parity than control women. CONCLUSION: A history of perforated appendix in childhood does not seem to have long term negative consequences on female fertility. This may have important implications for the management of young women with suspected appendicitis as the liberal attitude to surgical explorations with a subsequently high rate of removal of a normal appendix is often justified by a perceived increased risk of infertility after perforation. Women whose appendix was found to be normal at appendicectomy in childhood seem to belong to a subgroup with a higher fertility than the general population.  (+info)

Maternal age- and gestation-specific risk for trisomy 21. (7/2227)

OBJECTIVE: To provide estimates of maternal age- and gestational age-related risks for trisomy 21. METHODS: The prevalence of trisomy 21 was examined in 57,614 women who had fetal karyotyping at 9-16 weeks of gestation for the sole indication of maternal age of 35 years or more. On the basis of the maternal age distribution and the reported maternal age-related risk for trisomy 21 at birth, the expected number of trisomy 21 cases was calculated for each gestational age subgroup (9-10 weeks, 11-14 weeks and 15-16 weeks). The ratio of the observed to expected number of cases of trisomy 21 was then calculated and regression analysis was applied to derive a smoothened curve. The formula for maternal age- and gestational age-related risk was then applied to a population of 96,127 pregnancies that were examined at 10-14 weeks to calculate the expected number of trisomy 21 pregnancies, and this number was compared to the observed number of 326. RESULTS: In the 57,614 pregnancies there were 538 cases of trisomy 21. The relative prevalences of trisomy 21, compared to a prevalence of 1.0 at 40 weeks, was 10 exp(0.2718 x log(10)(gestation)2 - 1.023 x log10(gestation) + 0.9425). On the basis of the estimated maternal age- and gestational age-related risks, the expected number of trisomy 21 cases at 10-14 weeks of gestation in the 96,127 pregnancies was 329 (95% confidence interval 291-361), which was not significantly different from the observed number of 326 cases (chi2 = 0.02). CONCLUSION: The risk for trisomy 21 increases with maternal age and decreases with gestation. The prevalence of trisomy 21 at 12 and 16 weeks of gestation is higher than the prevalence at 40 weeks by 30% and 21%, respectively.  (+info)

Is maternal age a risk factor for mental retardation among children? (8/2227)

The purpose of this study was to determine whether older or very young maternal age at delivery is associated with mental retardation in children. Ten-year-old children with mental retardation (an intelligence quotient of 70 or less) were identified in 1985-1987 from multiple sources in the metropolitan Atlanta, Georgia, area. These children were subdivided into two case groups according to whether they had concomitant developmental disabilities or birth defects affecting the central nervous system (codevelopmental retardation) or did not have such disabilities (isolated retardation). Control children were randomly chosen from the regular education files of the public school systems in the study area. Data on sociodemographic variables were gathered from birth certificates. Children of teenaged mothers were not at increased risk for either form of retardation and children of mothers aged > or =30 years were not at increased risk for isolated retardation, in comparison with children of mothers aged 20-29 years. A markedly elevated risk of codevelopmental retardation was seen among black children of mothers aged > or =30 years that was not attributable to Down syndrome. A modest increase in risk for codevelopmental retardation was observed among white children born to older mothers, but it was entirely due to Down syndrome.  (+info)

When analysing effects of maternal age on child outcomes, many researchers estimate sibling models to control for unobserved factors shared between siblings. Some have included birth year in these models, as it is linked to maternal age and may also have i
In this analysis of a large multinational cohort increasing maternal age did not appear to impact negatively on offsprings adult respiratory health. Higher maternal age at delivery was related to increasing levels of FEV1 and higher FEV1/FVC ratio in the offspring, possibly more pronounced among females. Moreover, increasing maternal age at delivery was related to decreasing risk of asthma and asthma symptoms among female offspring, while these associations were not present among male offspring. The results were robust across countries with different sociocultural characteristics, and with adjustment for a range of factors (maternal smoking, asthma and educational level; and offspring number of older siblings, single child, number of siblings, birth weight, age, BMI, daycare attendance before 5 years of age and living environment in early childhood).. The impact of maternal age on lung function is a novel finding. It is of interest that effects were observed for FEV1 and FEV1/ FVC ratio rather ...
Please cite this paper as: Aasheim V, Waldenström U, Hjelmstedt A, Rasmussen S, Pettersson H, Schytt E. Associations between advanced maternal age and psychological distress in primiparous women, from early pregnancy to 18 months postpartum. BJOG 2012;119:1108-1116.. Objective To investigate if advanced maternal age at first birth increases the risk of psychological distress during pregnancy at 17 and 30 weeks of gestation and at 6 and 18 months after birth.. Design National cohort study.. Setting Norway.. Sample A total of 19 291 nulliparous women recruited between 1999 and 2008 from hospitals and maternity units.. Methods Questionnaire data were obtained from the longitudinal Norwegian Mother and Child Cohort Study, and register data from the national Medical Birth Register. Advanced maternal age was defined as ≥32 years and a reference group of women aged 25-31 years was used for comparisons. The distribution of psychological distress from 20 to ≥40 years was investigated, and the ...
It is fairly common in our society for women to delay pregnancy, especially when compared to our parents generation. For a variety of reasons including career goals and delayed marriage, many women are waiting until their 30s to start families. Waiting may consider these moms high-risk by most obstetricians for being of advanced maternal age, over 35 years old. Advanced maternal age is a well known risk factor for having a child with a chromosomal abnormality, such as Downs Syndrome. However, there has been little information on maternal age in relation to congenital abnormalities, or physical defects.. According to a new study, advanced maternal age might not be as risky as some may believe. In fact, it may actually decrease the risk of congenital malformations.. …this retrospective study used obstetric and ultrasound information collected from over 76,000 women at the time they presented for their routine second trimester ultrasound at Washington University in St. Louis (Mo.). ...
Objectives: To evaluate the associations between maternal age and obstetric and neonatal outcomes in primiparous women with emphasis on teenagers and older women. Design: A population-based cohort study. Setting: The Swedish Medical Birth Register. Participants: Primiparous women with singleton births from 1992 through 2010 (N=798 674) were divided into seven age groups: less than17 years, 17-19 years and an additional five 5-year classes. The reference group consisted of the women aged 25-29 years. Primary outcome: Obstetric and neonatal outcome. Results: The teenager groups had significantly more vaginal births (adjusted OR (aOR) 2.04 (1.79 to 2.32) and 1.95 (1.88 to 2.02) for age less than17 years and 1719 years, respectively); fewer caesarean sections (aOR 0.57 (0.48 to 0.67) and 0.55 (0.53 to 0.58)), and instrumental vaginal births (aOR 0.43 (0.36 to 0.52) and 0.50 (0.48 to 0.53)) compared with the reference group. The opposite was found among older women reaching a fourfold increased OR ...
Advanced Maternal Age AMA Definition - Advanced maternal age (AMA) refers to a pregnancy in which the mother is over the age of 35. The age of the mother....
Goetzinger KR, Shanks AL, Odibo AO, Macones GA & Cahill AG. (2017). Advanced Maternal Age and the Risk of Major Congenital Anomalies. Am J Perinatol , 34, 217-222. PMID: 27398707 DOI. This study aims to determine if advanced maternal age (AMA) is a risk factor for major congenital anomalies, in the absence of aneuploidy. ...Of 76,156 euploid fetuses, 2.4% (n = 1,804) were diagnosed with a major anomaly. There was a significant decrease in the incidence of major fetal anomalies with increasing maternal age until the threshold of age 35 (p , 0.001). Being AMA was significantly associated with an overall decreased risk for major fetal anomalies (adjusted odds ratio: 0.59, 95% confidence interval: 0.52-0.66). The subgroup analysis demonstrated similar results for women ≥ 40 years of age. Conclusion AMA is associated with an overall decreased risk for major anomalies. These findings may suggest that the all or nothing phenomenon plays a more robust role in embryonic development with advancing ...
Traditionally, women aged 35 and over who become pregnant are referred to as AMA, or advanced maternal age. But is this a thing of the past?
We extracted from the hospital episode statistics database records of women who delivered in English NHS acute trusts between 1 January and 31 December 2008. We restricted the sample to women aged between 15 and 44 years who had a singleton birth, and to NHS trusts whose obstetric units had more than 1000 deliveries in the 12 month period. Deliveries were included if the record contained information about mode of delivery in either the maternity tail or the procedure fields (OPCS codes: R17 to R25). The method of delivery was obtained primarily from the procedure fields. Where data had not been entered to these fields (0.6% of women), information was taken from the maternity tail. An elective caesarean section was defined by OPCS code R17, or by mode of delivery code 7 when data were obtained from the maternity tail. An emergency delivery was defined by codes R18 or 8, respectively.. Data on maternal age at delivery, ethnicity, and the NHS trust and region of treatment were obtained from the ...
I had a baby at age 27, which is above the mean age for a first baby in this country (25, I think), but well below the mean age for a first baby amongst my colleagues. Of the fifty or so women I went to med school with, I know of only FIVE who have had kids, even though the very youngest of us are almost thirty. I remember on my Labor and Delivery rotation in med school, all the girls in my class used to joke about how when they were up on the L&D board someday, thered by an AMA note by their name. (AMA = Advanced Maternal Age ...
0018 Background. Blood pressure (bp) level after birth may reflect the fetal cardiovascular environment, but few data exist on newborn bp. Methods. We report findings from a new cohort of pregnant women and their offspring, Project Viva. Enrollment as of September, 2000, is 1338 pregnant women (of a target 6000), and 581 have delivered. Data collected include maternal dietary, sociodemographic, economic, psychological, lifestyle, and clinical variables; and infant bp, pulse rate, length, weight, and circumferences measured during the first 2 days of life. We averaged 5 systolic bp readings taken with a Dinamap automated bp recorder. This abstract is limited to the first 260 measured newborns (131 girls and 129 boys) and partial maternal data. Results. The highest newborn systolic bp was in children of the oldest mothers, and the lowest in the maternal age group 20-24 years (⇓Table). Multivariate adjustment for infant birth weight and sex and for maternal body mass index, pregnancy weight gain, ...
What Creates The inability to conceive?. 1) Advancing mothers age: Historically before the last 20th century, ladies were developing in their teens as well as twenties, when age-related problems with the egg were not evident. Nevertheless, in our modern era, females are postponing youngster birth up until their thirties and forties, which has actually resulted in the exploration of the adverse effect of advanced maternal age on egg function. As a matter of fact, women age-related inability to conceive is the most usual root cause of infertility today. For unknown factors, as women age, egg numbers lower at a quick rate. And as aging takes place, egg top quality, or the chance of an egg being genetically typical, lowers too. For this reason the capacity to conceive a regular maternity lowers from when a lady is in her very early 30s into her 40s. A lady is seldom productive past the age of 45. This applies to the capacity to develop with her eggs, however not with benefactor eggs.. 2) Ovulation ...
Did you know that the rate of labor induction has drastically increased over the last 30 years? In this Evidence Based Birth® seminar, packed with facts, you will learn the evidence on 39-week induction and for induction at or past the due date. We cover the recent ARRIVE study in depth and well also cover a bit about advanced maternal age, and discuss the actual numbers of increase in stillbirth with older age.. Learning objectives for the Due Dates (with Advanced Maternal Age) seminar:. ...
Babymed.com articles & information about Advanced maternal age for mothers, expecting mothers, and soon to be expecting mothers.
At present there are three probable genetic mechanisms for the inheritance of AIS autosomal dominance (this produces a high proportion of affected members in a family), X linked transmission (X is the female sex chromosome) and what is called multifactorial. The last of these is particularly important and multiple genes (a gene is an active or functional segment of DNA which makes up a chromosome) are implicated. It is now known that environmental factors, using this term in a broad but
I am currently in my second IVF cycle. I transferred 3 embryos. All were at the 8 cell stage and all have a perfect rating of 1. I was a bit leary about doing this, but due to my age, (Im 39, going on 40 in Sept) I decided to go ahead and take the chance. Advanced maternal age plays a role in pregnancy success. I just had my first U/S and they found 2 sacs and we were able to see both fetal hearbeats. Im a bit guarded because I know that there is a thing called Vanishing Twin. There is a chance (about 40%) that I can lose one. Im delighted that this worked, but at the same time, at 6 weeks, its still a bit early for us to celebrate. After 12 weeks (first trimester) maybe ill be able to breathe, but until then, Im being cautious. What is your status with IVF? Is this your first time? Age ...
So today were going to talk about age now and when you get into the late 30s even over 35, they start to call you advanced maternal age.
Werlins research answers questions the causes of IVF failure in women of advanced maternal age. PGD research gives insights to increase fertility success.
46, married, female, built a family the new-fashioned way. Azoosperma was a hurdle, and I was also of advanced maternal age. Were now raising two beautiful daughters and our family is complete (and insurance wouldnt cover another fresh cycle at my advanced age anyhow ...
46, married, female, built a family the new-fashioned way. Azoosperma was a hurdle, and I was also of advanced maternal age. Were now raising two beautiful daughters and our family is complete (and insurance wouldnt cover another fresh cycle at my advanced age anyhow ...
Premature and congenitally ill babies are born as a consequence of late maternal age, induced fertility, labour treatments, deprived prenatal care and modification in lifestyle predilections.
TY - JOUR. T1 - The influence of laying date and maternal age on eggshell thickness and pore density in yellow-eyed penguins. AU - Massaro, Melanie. AU - Davis, Lloyd S.. PY - 2004/8. Y1 - 2004/8. N2 - In many bird species, eggs laid late in the breeding season hatch after a shorter incubation period than eggs that were laid early. The proximate mechanisms that cause these seasonal declines in incubation length remain poorly understood. We tested in Yellow-eyed Penguins (Megadyptes antipodes), Hipfners hypothesis that late-laid eggs have thinner eggshells with a higher pore density that allow embryos to develop more rapidly than in early-laid eggs. In this species incubation length declines with increasing female age, so we also investigated whether eggshell thickness and pore density varies with female age. In addition, differences in shell thickness and pore density between first- and second-laid eggs of the same clutch were examined. Eggshell thickness did not change with laying date and was ...
In 2008, 41% of all births in the United States occurred outside of marriage. Children born to unmarried mothers are often disadvantaged in young adulthood, including being less likely to graduate high school. In recent years, the age composition of mothers has changed; teen births declined substantially, and non-marital births are now most heavily concentrated among women in their twenties. This paper examines whether maternal age at birth differentiates the educational outcomes of children, and if this varies by maternal marital status. Data are from the linked Children and Young Adult sample of the 1979 National Longitudinal Survey of Youth (NLSY79). We find significant differences in the likelihood of high school graduation among youth born to a never-married versus a married mother. These disparities remain even after including controls for maternal age at birth, as well as social and economic characteristics of mothers prior to the birth. The marital status gap in the likelihood of ...
STUDY OBJECTIVE--The aim of the study was to investigate factors in stillbirth mortality in Italy. DESIGN--Italian stillbirth data from 1955 to 1979 were analysed using a log-linear Poisson model with arbitrary constraints on the parameters to identify the effects of maternal birth cohort, calendar period of stillbirth and maternal age. SETTING--Stillbirth data for the whole of Italy were obtained from the Italian Central Institute of Statistics for the years under examination. During this period the criteria for defining stillbirth did not change and the quality of birth registration was similar. MAIN RESULTS--Decreases in stillbirth mortality were marked and steady, starting for the generations born since 1920. A period effect in stillbirth trends was shown, but this was apparently smaller than the cohort trend. CONCLUSIONS--The cohort trend suggests that long term improvements in socioeconomic and general health conditions may be important factors in the diminishing stillbirth rates, as well ...
Maternal race/ethnicity, age, and socioeconomic status (SES) are important factors determining birth outcome. Previous studies have demonstrated that, teenagers, and mothers with advanced maternal age (AMA), and Black/Non-Hispanic race/ethnicity can independently increase the risk for a poor pregnancy outcome. Similarly, public insurance has been associated with suboptimal health outcomes. The interaction and impact on the risk of a pregnancy resulting in a NICU admission has not been studied. Our aim was, to analyze the simultaneous interactions of teen/advanced maternal age (AMA), race/ethnicity and socioeconomic status on the odds of NICU admission. The Consortium of Safe Labor Database (subset of n = 167,160 live births) was used to determine NICU admission and maternal factors: age, race/ethnicity, insurance, previous c-section, and gestational age. AMA mothers were more likely than teenaged mothers to have a pregnancy result in a NICU admission. Black/Non-Hispanic mothers with private insurance
Even before full implementation of the policy for combined risk assessment during the first trimester in Denmark, the number of infants born with Downs syndrome decreased by about 50% and the number of cases diagnosed prenatally increased by around 30%. The number of fetuses and newborn infants with Downs syndrome diagnosed prenatally or postnatally increased in the period 2000-5, with a slight decline in 2006 (fig 2). This was partly due to increasing maternal age, but was as expected because more fetuses with Downs syndrome are lost spontaneously than those that are chromosally normal. This increased rate has been estimated at around 25% from week 14 to term.[4] Based on the known distribution of maternal age at delivery in 2005 and 2006, 132 and 135 infants with Downs syndrome would have been expected in our population of 65 000 liveborn infants if the mothers had no prenatal intervention. Downs syndrome was diagnosed in 31 infants postnatally and 130 prenatally in 2005 and in 32 infants ...
Even before full implementation of the policy for combined risk assessment during the first trimester in Denmark, the number of infants born with Downs syndrome decreased by about 50% and the number of cases diagnosed prenatally increased by around 30%. The number of fetuses and newborn infants with Downs syndrome diagnosed prenatally or postnatally increased in the period 2000-5, with a slight decline in 2006 (fig 2). This was partly due to increasing maternal age, but was as expected because more fetuses with Downs syndrome are lost spontaneously than those that are chromosally normal. This increased rate has been estimated at around 25% from week 14 to term.[4] Based on the known distribution of maternal age at delivery in 2005 and 2006, 132 and 135 infants with Downs syndrome would have been expected in our population of 65 000 liveborn infants if the mothers had no prenatal intervention. Downs syndrome was diagnosed in 31 infants postnatally and 130 prenatally in 2005 and in 32 infants ...
A mothers age at menopause may predict her daughters fertility in terms of the numbers of eggs remaining in her ovaries, according to the new research published online in Europes leading reproductive medicine journal Human ...
There is no definite way to avoid having a baby with Downs syndrome. There will always be probabilities, sometimes greater than others. A big factor is the age at which amother conceives. At age 25, probabilities are 1 in 1,250; at age 40 probabilities increase to 1 in 100 (Shriver 2007). Parents with Down syndrome, or with an abnormal 21 chromosome are also at higher risk of conceiving a child with the condition. Many tests can be done before the child is born so that the parents may prepare for the childs special needs (Shriver 2007).. A series of two surveys on exposure to contraceptive pills prove that there may be an impact at or around the time of pregnancy on Down syndrome probabilities. A study done by Martinez-Frias and Read infer that that there will be a slight increased rate of Down Syndrome for maternal age group 20-29, a decreased rate for maternal age group 30-39 (Read). ...
It has been known for more than half a century that the risk of conceiving a child with trisomy increases with advanced maternal age However the origin of the high susceptibility to nondisjunction of whole chromosomes and precocious separation of sister chromatids leading to aneuploidy in aged oocytes and embryos derived from them cannot be traced back to a single disturbance and mechanism Instead analysis of recombination patterns of meiotic chromosomes of spread oocytes from embryonal ovary and of origins and exchange patterns of extra chromosomes in trisomies as well as morphological and molecular studies of oocytes and somatic cells from young and aged females show chromosome specific risk patterns and cellular aberrations related to the chronological age of the female In addition analysis of the function of meiotic and cell cycle regulating genes in oogenesis and the study of the spindle and chromosomal status of maturing oocytes suggest that several events contribute synergistically to ...
The study by Nybo Andersen and colleagues is undoubtedly generalizable. Because of its population-based design, it provides the best estimates to date of the incidence of pregnancy loss and its association with maternal age and previous reproductive history. The authors do not attempt to explain their findings. The cause of miscarriages in older women now seems to be well understood: Chromosomal deletions and fatal trisomies resulting from nondisjunction during meiosis are probably the underlying biological mechanisms (1). Whether these mechanisms also explain the increased likelihood of ectopic pregnancy in older women remains to be seen. The study by Nybo Andersen and colleagues favors the hypothetical role of the fertilized egg itself in the pathogenesis of ectopic nidation. Accumulation of other risk factors with increasing age (i.e., those impairing tubal function) might also explain the association (2). The relation between stillbirth and maternal age, straightforward as it may seem, is ...
A group of patients (150) suffering from keratoconus were asked their mothers age at their birth. A statistically significant excess of older mothers as compared with the general population was found. The social class of the patients was found to have a distribution different from the general population, and it is suggested that this is related to the patients maternal age. ...
The association of maternal age with infant mortality, child anthropometric failure, diarrhoea and anaemia for first births: evidence from 55 low- and middle-income countries ...
P-434 Does partner relationship context and adjustment during the transition to parenthood differ according to maternal age and mode of conception? [Abstract]. Human Reproduction 25 (S1) , i283-i284. 10.1093/humrep/de.25.s1.425 ...
A pregnancy over 35 is considered a geriatric pregnancy. In recent years, geriatric pregnancy has come to be known as the pregnancy of advanced maternal age.
Its more than just the number of miscarriages that determines the likelihood of structural chromosome abnormalities, say researchers from the Netherlands. In couples who are trying to conceive and who have had two or more miscarriages, young maternal age at the time of a second miscarriage, a history of three or more miscarriages, and a history of two or more miscarriages in siblings or parents of either partner make the couple more likely to be carriers of such anomalies, according to the results of a nested case-control study.
The following pages link to Template:Genetic risk maternal age table: Displayed 4 items. View (previous 100 , next 100) (20 , 50 , 100 , 250 , 500) ...
Dont get me wrong, I appreciate the red carpet treatment. I love knowing that my odds of having a Down Syndrome or Trisomy 18 baby are LOW LOW LOW after the testing was done, we have none of the genetic markers. Next well do neural tube defect testing so you know - MORE PICTURES! Plus I get to see the sex by then so thatll be fun ...
Dont get me wrong, I appreciate the red carpet treatment. I love knowing that my odds of having a Down Syndrome or Trisomy 18 baby are LOW LOW LOW after the testing was done, we have none of the genetic markers. Next well do neural tube defect testing so you know - MORE PICTURES! Plus I get to see the sex by then so thatll be fun ...
Q: Ive always had a pretty healthy diet but now that I am pregnant, what vitamins, minerals and other nutrients are critical to include for optimal health for me and my baby?. Response from Margaret Connor, MPH, CHC, The Wellness Pantry. A: It sounds like you have already helped yourself and your baby by eating healthy before your pregnancy began, which is terrific. Now lets examine how our metabolic needs do increase during pregnancy. The following vitamins and minerals play a special role in your health and that of your childs during pregnancy (and often postpartum as well). One exciting detail to consider is that the absorption of nutrients across our intestinal barrier typically increases during pregnancy, so eating good sources of these vitamins and minerals will go a long way towards keeping you equipped with the necessary nutrients.. FOLATE - Youve probably heard your OB mention this as a valuable supplement that you might have been taking even before you became pregnant. The evidence ...
Advanced Paternal Age APA Definition - Advanced paternal age (APA) most commonly refers to a man who is 40 years or older at the time of conception. As a....
BabyAfter40.com: Women who conceive and deliver after the age of 50 years, following egg donation, do not have a reduced parenting capacity compared with younger women, according to new study findings.
I did discuss a little bit of a plan with my doctor. She didnt want to make any decisions until we get there, and I think that is the right thing to do in my case. I am on the edge of advanced maternal age. I cant decide if I should just wait the extra month and be automatically high risk or leave that designation up to chance. It would eliminate some arguments with my insurance company. My doctor didnt really think losing weight would help me much, but she agreed that getting in fighting shape couldnt hurt. I believe that my pregnancy was a failed stress-test and a wake-up call to start taking care of myself and get healthy. My BP is still higher than it was pre-pregnancy, so I wouldnt be surprised if I end up having to deal with that at some point. I didnt discuss it with her at my previous appointments because I thought it would go down if I got the weight off. We will end up talking about it at my first appointment or next checkup ...
I did discuss a little bit of a plan with my doctor. She didnt want to make any decisions until we get there, and I think that is the right thing to do in my case. I am on the edge of advanced maternal age. I cant decide if I should just wait the extra month and be automatically high risk or leave that designation up to chance. It would eliminate some arguments with my insurance company. My doctor didnt really think losing weight would help me much, but she agreed that getting in fighting shape couldnt hurt. I believe that my pregnancy was a failed stress-test and a wake-up call to start taking care of myself and get healthy. My BP is still higher than it was pre-pregnancy, so I wouldnt be surprised if I end up having to deal with that at some point. I didnt discuss it with her at my previous appointments because I thought it would go down if I got the weight off. We will end up talking about it at my first appointment or next checkup ...
The largest study of its kind has examined the impact of advanced maternal age of the health of babies and mothers. The Canadian Institute for Health
I am getting ready to do a 2nd IVF for a 2nd child. The first IVF was successful at age 35. I am turning 40 in August and my doctor is recommending PGD because of my advanced maternal age. My husband and I are healthy and have no genetic defects running in our family but Ive read several articles saying that PGD may increase chances of success because of the ability to test and select the highest quality embryos. I didnt see any posts on this subject on your message board for the last 4 years so I am wondering if your opinions have changed on the subject or if you still believe it actually decreases success rates by 1/3? I am leaning towards not doing it because of our successful IVF on the first try 5 years ago and no family history but I want to give ourselves the best chances possible for another successful IVF. I would appreciate any new insight ...
I am getting ready to do a 2nd IVF for a 2nd child. The first IVF was successful at age 35. I am turning 40 in August and my doctor is recommending PGD because of my advanced maternal age. My husband and I are healthy and have no genetic defects running in our family but Ive read several articles saying that PGD may increase chances of success because of the ability to test and select the highest quality embryos. I didnt see any posts on this subject on your message board for the last 4 years so I am wondering if your opinions have changed on the subject or if you still believe it actually decreases success rates by 1/3? I am leaning towards not doing it because of our successful IVF on the first try 5 years ago and no family history but I want to give ourselves the best chances possible for another successful IVF. I would appreciate any new insight ...
A new study reveals that maternal demographic factors such as social status, ethnicity and maternal age can predict the likelihood of operative births in the UK.
Two studies of its abundance in Palau were conducted using point counts from April to May 1991 (Wiles et al. 1997) and from April to May 2005 (G. Wiles, unpublished data). Both studies were inconclusive about total numbers, but provided baseline encounter rates that could, and should, be repeated in the future to determine population trends. Data from 2005 have not yet been analyzed, but bats were common in many locations. Numbers appeared to have increased since 1991. Prior to the early 1990s the species had gone through a large decline due to commercial exploitation with thousands of bats being exported annually to markets in Guam and the Northern Marianas. In the 1940s the species was considered abundant (Marshall 1945, as reported in Wiles et al. 1997), but by the 1970s numbers were starting to decline (Owen 1977), and at some point in the 1980s this trend reversed itself with less bats being exported (Wiles et al. 1997 ...
Advanced maternal age has been shown to influence follicular and luteal dynamics in bovine ovary resulting in reduced fertility. The overall objective of the four studies presented in this thesis is to identify the maternal age-associated transcriptional changes in granulosa cells of the dominant follicles during follicle development. In the first study, mRNA expression levels of housekeeping genes were measured by real-time quantitative PCR (RT-qPCR) in granulosa cells of dominant follicles and FSH-stimulated follicles to select and validate suitable reference genes for relative gene expression analyses during maternal and follicular aging. Stability of six reference genes (GAPDH, ACTB, EIF2B2, UBE2D2, SF3A1 and RNF20) was analyzed using GeNorm, DeltaCT and NormFinder programs and comprehensive ranking order was determined based on these programs. Geometric mean of multiple genes (UBE2D2, EIF2B2, GAPDH and SF3A1) was more appropriate reference control than individual genes for the comparison of ...
A study in the city of Sakarya in Turkey determines that postnatal infant death rate is 2.5% in adolescent pregnancies and 0.1% adult pregnancies [26]. Malabarey, et al. [7] in their studies in the USA evaluate the effect of young maternal age on adverse obstetrical and neonatal outcomes. They stated that the rate of infant deaths in pregnant adolescents below 15 is 0.86%, and it is 0.41% in pregnant adolescents over 15. In another study conducted in the USA, the rate of neonatal mortality is reported as 7.3% between the ages of 10-15, 4.9% between the ages of 16-17 and 4.1% between the ages of 18-19, so, the younger the mothers are, the higher the rate of deaths is [27]. In a study conducted in India, it is stated that the rate of infant deaths earlier than 48 hours is 5.1% in adolescents and it is 1.7% in adults, which is significantly a high rate [15]. The increased neonatal mortality in infants born to teenage mothers might be mediated by low weight gain during pregnancy, preterm birth, ...
Mitochondria are the most abundant organelles within the oocyte and are fundamental for energy metabolism, spindle formation and chromosome segregation. Therefore it is likely that a reduction in mitochondria number or function may explain the decreased quality, developmental potential and increased frequency of chromosomal non-disjunction in oocytes from older women, especially when coupled with IVF stimulation regimens. The aim of this study was to delineate, using a novel bovine model of human IVF stimulation, the effects of ovarian stimulation regimens and maternal age on mitochondrial DNA copy number and function of the cumulus-oocyte-complex. Seven young (4 years old) and five old (11 years old) cloned cows with an identical genetic background, and managed as one herd, were subjected to repeated rounds of ovarian stimulation; four natural (hCG), three mild (FSH and hCG) and two heavy stimulated (GnRH agonist, FSH and hCG) cycles. Individual cumulus-oocyte-complexes were collected. The ...
Egg infertility is a predisposition to miscarriages, infertility, and trisomic pregnancies caused by increased frequency of chromosome segregation errors in the eggs of women of advanced maternal age (AMA). Egg infertility is now a significant public health issue, with 1 in 5 US women now attempting her first pregnancy after age 35. Increased rates of egg infertility temporally coincide with rising levels of FSH that occur with age. By age 42, up to 87% of embryos are aneuploid, and 40-50% of women experience egg infertility. An Introductory Editorial will present an overview of causative factors and potential therapeutic strategies to prevent egg aneuploidy and infertility. Papers in series will be comprised of data drawn from studies performed both in animals and in humans. Part I will discuss endocrine and other molecular changes implicated in the pathogenesis of AMA oocyte aneuploidy and infertility. Section 1 will discuss defects that emerge with age in controlling the fidelity of meiotic oocyte
BACKGROUND Women in high resource nations are increasingly delaying childbearing until their thirties. Delayed childbearing poses challenges for the spacing of a womans pregnancies. Inter-pregnancy intervals |12 months are associated with risk for adverse pregnancy outcome, yet increased maternal age at delivery is linked with increased risk. The optimal inter-pregnancy interval for older mothers is uncertain. This systematic review will aim to assess the relation between inter-pregnancy interval and perinatal and maternal health outcomes in women who delay childbearing to age 30 and older. METHODS We will search MEDLINE, CINAHL, and EMBASE databases for peer-reviewed articles on the effects of inter-pregnancy interval on perinatal and maternal health outcomes among women over 29 years at the time of first birth, in high-income countries. To assess the quality of studies, the Cochranes Collaboration tool for assessing risk of bias will be used for randomized controlled trials, and the Newcastle
Earlier age of menarche has been associated with an increased risk of chronic diseases during adulthood, but whether early menarche has intergenerational effect is not clear. In this population-based cross-sectional study, we recruited children from 26 primary schools using cluster random probability sampling in Shanghai, China, in 2014. We used multiple linear regression models to estimate the adjusted associations of maternal age of menarche (MAM) with offspring body mass index (BMI). We also used the mediation analysis to examine the contribution of maternal BMI and gestational diabetes to offspring BMI. A total of 17,571 children aged 6-13 years were enrolled, of whom 16,373 had their weight and height measured. Earlier MAM was associated with higher child BMI in boys (− 0.05 z-score per year older MAM, 95% CI − 0.08 to − 0.02) and in girls (− 0.05 z-score per year older MAM, 95% CI − 0.07 to − 0.02). Maternal BMI positively mediated the association of MAM with offspring BMI in both
Background The incidence rates of childhood onset type 1 diabetes are almost universally increasing across the globe but the aetiology of the disease remains largely unknown. We investigated whether birth order is associated with the risk of childhood diabetes by performing a pooled analysis of previous studies. Methods Relevant studies published before January 2010 were identified from MEDLINE, Web of Science and EMBASE. Authors of studies provided individual patient data or conducted pre-specified analyses. Meta-analysis techniques were used to derive combined odds ratios (ORs), before and after adjustment for confounders, and investigate heterogeneity. Results Data were available for 6 cohort and 25 case-control studies, including 11 955 cases of type 1 diabetes. Overall, there was no evidence of an association prior to adjustment for confounders. After adjustment for maternal age at birth and other confounders, a reduction in the risk of diabetes in second- or later born children became ...
Women having both first trimester nuchal translucency and second trimester serum screening tests are likely to receive two different Down s syndrome risks. Neither will be correct, and we describe how to calculate a valid combined risk. This uses the reported serum-based risk and a likelihood ratio derived from the nuchal translucency report....
BACKGROUND:A belief has existed for many years that severe myopia is a direct indication for cesarean section or an instrumental vaginal delivery, although many academic papers negated this opinion. The aim of this study was to analyze the mode of delivery of myopic patients in the years 1990, 2000, and 2010. MATERIAL AND METHODS:Medical records of 3027 women in labor from the 1st Department of Obstetrics and Gynecology, Medical University of Warsaw were analyzed in 3 time periods: year 1990 - group 1 (G1), year 2000 - group 2 (G2), and 2010 - group 3 (G3). Maternal age, severity and proportion of myopia, ophthalmological consultations, and mode of delivery were assessed. RESULTS:In G1 there were 992 patients, in G2 there were 1010 patients, and in G3 there were 1025 patients. Myopic women in labor accounted for 20% of G1, 12% of G2, and 20% of G3. The mean maternal age was ±29.4 years in G1, ±30 years in G2, and ±31.5 years in G3. Myopia was divided into 3 levels of severity depending on the degree
Downloadable (with restrictions)! We examine birth order effects on academic achievement for ten-year-old students using data for the entire population of fifth graders in Norway 2007/2008. The analysis thus adds to a thin empirical literature focusing on birth order effects among young children. We find that being firstborn confers a significant advantage in families with two, three and four children. The analysis makes two other contributions. First, we provide evidence that unless mothers age at childbirth is included among the control variables, only small and imprecise birth order effects are revealed in families with low socioeconomic status. Second, we provide some evidence that the birth order effects differ across families with highly educated and less educated mothers, which lend support to the resource dilution model over the confluence model.
Older paternal and maternal age is associated with having a child with autism, according to a study from the University of Texas Health Science Center in
To describe the obstetric outcome in women at ages >= 45. A retrospective cohort study on a large existing database covering all deliveries in the Flanders region, Belgium, was performed, comparing obstetric outcomes at age 25, 35, 40 and 45 or older, for the period 2005-2010. In the period studied, 421 women gave birth at maternal age >= 45 vs 3,405, 15,206, 22,586 at ages 40, 35 and 25, respectively. With advancing maternal age, a significant linear increase for low birth weight (< 2,500 g) and preterm delivery (< 37, < 35 weeks and < 29 weeks), maternal hypertension and diabetes, both primary and secondary caesarean section, was noted. Between ages 40 and >= 45, both fetal and early neonatal death demonstrated a significant rise from 4.9/1,000 and 1.8/1,000 to 26/1,000 and 9.5/1,000, respectively. With advancing maternal age, a gradual but not statistically significant decline in the proportion of male fetuses was noted, from 51.6% at 25, to 47.2% in the oldest group. Multivariate analysis ...
Irva Hertz-Picciotto, professor of public health sciences, a researcher at the UC Davis MIND Institute and the studys senior author, says the reason that having an older parent places a child at risk for autism is not known. We still need to figure out what it is about older parents that puts their children at greater risk for autism and other adverse outcomes, so that we can begin to design interventions, Hertz-Picciotto says.. UC DAVIS (US)-Advanced maternal age is linked to a significantly elevated risk of having a child with autism, regardless of the fathers age, according to a new study.. Paternal age is a factor only when the father is older and the mother is younger than 30.. Researchers at the University of California, Davis, looked at all births in California during the 1990s and found that the incremental risk of having a child with autism increased by 18 percent-nearly one fifth-for every five-year increase in the mothers age.. A 40-year-old womans risk of having a child later ...
The primary aim of this study was to determine the predictive value of prenatal ultrasound and echocardiography for prognosis in congenital heart disease (CHD) with coexisting diaphragmatic hernia (DH) in a tertiary care center. Eleven records from the database of the Department for Diagnoses and Prevention of Congenital Malformations, Polish Mothers Memorial Hospital Research Institute, were reviewed. The mean maternal age was 29,2 ± 5,1 years, and the mean gestational age at the time of diagnosis was 28,4 ± 6,7 weeks. No information was available for children discharged from hospital. Data of eight cases of prenatal DH and complex heart disease from the literature were also analyzed. Three fetuses survived the neonatal period. In each of these, CHD was other than the urgent or critical type, defined as not requiring cardiac surgical intervention in the first day or month of life. Both sets of data collected from our center and the published literature confirmed the unfavorable prognosis for ...
Teenage pregnancy and childbearing have become pressing social concerns in the United States, where approximately one million teenagers become pregnant each year, and half that number give birth.1 An enormous quantity of research has shown that teenage childbearing is linked to a host of negative social, economic and medical consequences for both mother and child.
I am on my knees, my face in the seat of a rocking recliner. The clock passes midnight and its just the four of us-me, my husband, our baby and a nurse-inside an abortion clinic 90 miles from our home and friends. There is no bed or doctor to ease my way toward delivery of my son, whose life I am ending as my first true act of motherhood.. The nightmare began unfolding for my husband, David, and me on Halloween 2006, the day I answered a call at the office from my doctor informing me of the far-from-optimal results of my prenatal Quad screening, a series of tests Id agreed to due to my advanced maternal age of 35. We were a solid, mature couple reveling in the joy of my growing belly and the limitless possibilities of this much-wanted first pregnancy. A negative outcome was something wed never considered, nor been prepared for by my doctor.. My OBs office sprang into action, securing me a same-day appointment with a high-risk doc who would provide a level II ultrasound and an ...
Maybe moms are taking on more responsibilities -- including cooking the food for the kids, with these high-fat choices, speculates study author Jerica Berge, Ph.D. In parenting, there are conflicting demands and tradeoffs. It could [also] be theyre too tired at the end of the day and might not want to go to the gym.. The researchers looked at data from Project EAT (Eating and Activity in Teens and young adults), which followed participants over an 11-year period, from 1998 to 2009. Study participants listed their height and weight, and answered a questionnaire on food intake and exercise.. The fact that young mothers also consumed a similar amount of healthy food as women who werent mothers could suggest that they are trying to be good role models for their children, Berge says. Their use of higher-fat foods may stem from having less time to cook.. ...
Hormone concentrations during early fetal development -- that may affect the childs development and increase the mothers risk for breast and ovarian cancer years later -- are significantly affected by maternal age, body mass index and race rather than lifestyle, according to a Rutgers study.
Hello! Just a quickie for me because Im about to get on the phone to tell family our news. It all went well at the scan, Im in total shock that in 4 weeks the baby/foetus can go from being a blob to an identifiable baby shape. The doctor we saw said that at 11wks3day he would hope that the baby would measure between 44 and 48mm head to toe - in fact, the baby is measuring 51mm so he/she is going to be tall like DH and I. Just as long as the babys not wide as well - ouch!! DH found it amusing on the way home to inform me for the first time that he was a pretty big baby at birth!! We wont get the results of the blood test and our final assessment for the Downs Syndrome risk until Monday night, but he didnt find any of the high risk signs on the scan, so were hopeful. Seeing the baby looking like a baby has made all of this seem a bit more real. I think it will sink in even more once weve told everyone our news ...
Page 17 - Morning everyone! Im doing a paper for development psych (ugh) and was wondering how old most of you were when you had your first child and what you think the best age to start a family is. I
Page 3 - Morning everyone! Im doing a paper for development psych (ugh) and was wondering how old most of you were when you had your first child and what you think the best age to start a family is. I
I always enjoy looking back at the research developments of the year. I thought I would share with you what I found to be some of the significant findings throughout 2017... What a year its been! ~ Maureen Link between parental age and autism, explained Study of 5,000 people suggests that parents in their mid-40s are…
one of the young mothers there started struggling a bit with one of her children. She was trying to hold her baby and help the other child and seemed to be getting frustrated. Then she looked at me and said, Could you hold the baby for a second? Could I? Could I? Babies? Heck, yea ...
What chance the combined ages of triplets will ever add up exactly to their mothers age? Plus the solution to puzzle #60. Set by Rob Eastaway
This tendency increases with maternal age. Fertilization of two different oocytes by two different spermatozoa results in ... Geirsson RT (1991). "Ultrasound instead of last menstrual period as the basis of gestational age assignment". Ultrasound in ...
Trimble, Benjamin, K.; Patricia A. Baird; John M. Opitz (1978). "Maternal age and down syndrome: Age-specific incidence rates ... Maternal age has been shown to be related to intelligence with younger mothers tending have children of lower intelligence than ... However, another study found that when influences such as maternal age, mother's personality and home environment, there was no ... Zybert, P; Stein Z; Belmont L. (1978). "Maternal age and children's ability". Perceptual and Motor Skills. 47 (3): 815-818. doi ...
"Mitochondria, maternal inheritance, and male aging." Current Biology 22.18 (2012): 1717-1721. Dowling, Damian K., A. Larkeson ... Because of maternal inheritance, mtDNA has no selection in males. Instead, mutations only deleterious to males could be ... They demonstrated that mtDNA polymorphism is responsible for male aging, while there is no significant effect on female ... 4 relative to maternal inheritance in mice. Hence, selection can act on male-specific deleterious mutations when they are ...
... the risk of conceiving a child with it increases with a woman's age. The average maternal age for conceiving a child with this ... mean maternal age for this disorder is 32½ Edwards, J.H.; Harnden, D.G.; Cameron, A.H.; Crosse, V. Mary; Wolff, O.H. (April 9, ... Modifications regarding maternal age and markers]". Ceska Gynekol (in Czech). 72 (1): 49-52. PMID 17357350. Papp C, Ban Z, ... About 8-12% of infants survive longer than 1 year.[better source needed] One percent of children live to age 10. However, these ...
Camus MF, Clancy DJ, Dowling DK (September 2012). "Mitochondria, maternal inheritance, and male aging". Current Biology. 22 (18 ... The asymmetry of maternal and paternal expression suggests that some kind of conflict between these two genomes might be ... Why inheritance ended up being maternal, rather than paternal, is also much debated, but one key hypothesis is that the ... Due to differences in methylation status of gametes, there is an inherent asymmetry to the maternal and paternal genomes that ...
Camus MF, Clancy DJ, Dowling DK (September 2012). "Mitochondria, maternal inheritance, and male aging". Current Biology. 22 (18 ... The asymmetry of maternal and paternal expression suggests that some kind of conflict between these two genomes might be ... Another consequence of the maternal inheritance of the mitochondrial genome is the so-called Mother's Curse.[78] Because genes ... Due to differences in methylation status of gametes, there is an inherent asymmetry to the maternal and paternal genomes that ...
Nondisjunction is related to advanced maternal age, although due to its rarity, the maternal age effect in pentasomy X is ... Dey, Subrata Kumar; Ghosh, Sujoy (29 August 2011). "Etiology of Down Syndrome: Risk of Advanced Maternal Age and Altered ... Mikwar M, MacFarlane AJ, Marchetti F (4 July 2020). "Mechanisms of oocyte aneuploidy associated with advanced maternal age". ... Chiang T, Schultz RM, Lampson MA (1 January 2012). "Meiotic Origins of Maternal Age-Related Aneuploidy". Biology of ...
Sternlicht M, Staaby J, Sullivan I (December 1975). "Birth order, maternal age, and mental retardation". Mental Retardation. 13 ...
Young maternal age and increases the risk. Studies differ whether the risk is different in different trimesters. Limited data ... The risk of severe malaria by Plasmodium falciparum is three times as high in pregnant women, with a median maternal mortality ... Maternal physiological changes including a decrease in respiratory volumes and urinary stasis due to an enlarging uterus. The ...
doi:10.1016/B978-0-12-378630-2.00474-6. Hassold T, Jacobs P, Kline J, Stein Z, Warburton D (July 1980). "Effect of maternal age ... The probability of nondisjunction in human oocytes increases with increasing maternal age, presumably due to loss of cohesin ... Tsutsumi M, Fujiwara R, Nishizawa H, Ito M, Kogo H, Inagaki H, Ohye T, Kato T, Fujii T, Kurahashi H (May 2014). "Age-related ... Because of recombination, an individual chromatid can consist of a new combination of maternal and paternal genetic information ...
The relation between number of older brothers and male homosexuality is not an artifact of higher maternal or paternal age at ... Slater E (13 January 1962). "Birth order and maternal age of homosexuals". The Lancet. 1 (7220): 69-71. doi:10.1016/S0140-6736( ... It has generally been thought that this maternal response would not apply to first born gay sons and that they may owe their ... This implies that the birth order phenomenon cannot be explained by increased mutation rates in the ova or sperm cells of aging ...
... incidence increases substantially as maternal age rises. Less is understood about the role of maternal age in sex chromosome ... Dey, Subrata Kumar; Ghosh, Sujoy (29 August 2011). "Etiology of Down Syndrome: Risk of Advanced Maternal Age and Altered ... Nondisjunction is related to advanced maternal age. In common aneuploidies such as Down syndrome, the relationship with ... Mikwar M, MacFarlane AJ, Marchetti F (4 July 2020). "Mechanisms of oocyte aneuploidy associated with advanced maternal age". ...
Age specific maternal defence in Gargaphia solani (Hemiptera: Tingidae). Behav Ecol Sociobiol. 11:7-11. ... Maternal care in the Hemiptera: ancestry, alternatives, and current adaptive value. pp. 94-115. In: Choe, J.C. & B.J. Crespi. ... Maternal care by a species of Pselaphacus Percheron (Coleoptera: Erotylidae: Erotylinae) from Peru. Coleop Bull. 64:116-118. ... Maternal behaviour and nest recognition in the subsocial earwig Labidura riparia Pallas (Dermaptera: Labiduridae). Ethology. 89 ...
Campbell CL, Furlotte NA, Eriksson N, Hinds D, Auton A (2015). "Escape from crossover interference increases with maternal age ... In humans, recombination rate increases with maternal age. Furthermore, placement of female recombination events appears to ... become increasingly deregulated with maternal age, with a larger fraction of events occurring within closer proximity to each ...
Maternal age is the only known risk factor. Women at 40 years have a four times higher risk for a child with Klinefelter ... The extra chromosome is retained because of a nondisjunction event during paternal meiosis I, maternal meiosis I, or maternal ... They may have less muscle control and coordination than other boys of their age. During puberty, the physical traits of the ...
The risk of Trisomy 21 increases with maternal age with the risk being 1/2000 (0.05%) at age 20 increasing to 1/100 (1%) at age ... Hassold T, Hunt P (December 2009). "Maternal age and chromosomally abnormal pregnancies: what we know and what we wish we knew ... Hook, EB (September 1981). "Rates of chromosome abnormalities at different maternal ages". Obstetrics and Gynecology. 27 (1): ... "New observations on maternal age effect on germline de novo mutations". Nature Communications. 7: 10486. Bibcode:2016NatCo... ...
Still, advanced maternal age causes decreased success rates; women aged 38-39 years appear to have reasonable success during ... maternal age, follicle count at hCG administration day, follicle rupture, and the number of uterine contractions observed after ... Women whose age is becoming a major factor in fertility may not want to spend that extra time. The number of samples ( ... However, for women aged over 40 years, there appears to be no benefit after a single cycle of COH/IUI. Medical experts ...
It is more likely with advanced maternal age. Some oocytes have multiple nuclei, although it is thought they never mature. ... Maternal cells also synthesize and contribute a store of ribosomes that are required for the translation of proteins before the ... Heasman, J. (2006). "Maternal determinants of embryonic cell fate". Seminars in Cell & Developmental Biology. 17 (1): 93-8. doi ... During the growth of the oocyte, a variety of maternally transcribed messenger RNAs, or mRNAs, are supplied by maternal cells. ...
As maternal age increases so does egg size. At the beginning of the breeding season females lay smaller eggs compared to the ... It has been suggested that the two species diverged during Pleistocene ice age. Both have the same number of chromosomes (2n=17 ... Eggs laid in the last part of the breeding season are smaller in size due to deteriorating maternal health. Research suggests ... depending on the female's age and its origins". Comparative Biochemistry and Physiology C. 154 (3): 172-179. doi:10.1016/j.cbpc ...
Full maternal inheritance is present within DM1, repeat expansion length is linked to maternal age and the earliest instance of ... "Increased trinucleotide repeat instability with advanced maternal age". Human Molecular Genetics. 6 (12): 2135-2139. doi: ... Maternal transmission has been observed to only consist of an increase in repeat units of 1 while the paternal transmission is ... Typical age at symptom onset is 5-15, with symptoms progressively getting worse over time. Friedreich's ataxia is an autosomal ...
Low birth weight can also vary by maternal age. In 2008 the rate of low birth weight was the highest in babies born to women ... but it was also shown that this relationship is fully explained by maternal weight. Middle aged adults with low birth weight ... A low birth weight can be caused either by a preterm birth (low gestational age at birth) or of the infant being small for ... A baby born small or large for gestational age (either of the two extremes) is thought to have an increased risk of obesity in ...
Tallamy, D.W. (1982). "Age specific maternal defense in Gargaphia solani (Hemiptera: Tingidae)". Behavioral Ecology and ... Kearns, R.S.; Yamamoto, R.T. (1981). "Maternal behavior and alarm response in the eggplant lace bug, Gargaphia solani Heidemann ... Douglas Tallamy found that maternal defensive behaviour in this species is consistent with the theory, since mothers became ... Tallamy, D.W.; Denno, R.F. (1981). "Maternal care in Gargaphia solani (Hemiptera: Tingidae)". Animal Behaviour. 29 (3): 771-778 ...
Age specific maternal defence in Gargaphia solani (Hemiptera: Tingidae). Behav Ecol Sociobiol. 11:7-11. Tallamy, D.W.; Walsh, E ... Maternal care in the Hemiptera: ancestry, alternatives, and current adaptive value. pp. 94-115. In: Choe, J.C. & B.J. Crespi. ... Maternal care by a species of Pselaphacus Percheron (Coleoptera: Erotylidae: Erotylinae) from Peru. Coleop Bull. 64:116-118. ... Maternal behavior and clutch manipulation in the ring-legged earwig (Dermaptera: Carcinophoridae). Journal of Insect Behaviour ...
Maternal age less than 20 years or over the age of 35 ... Small for gestational age / Large for gestational age. *Preterm ... Maternal care related to the. fetus and amniotic cavity. *amniotic fluid *Oligohydramnios ... Maternal factors complicating pregnancy,. labour or delivery. .mw-parser-output .nobold{font-weight:normal}. placenta. * ... This leads to decrease oxygen carried past the maternal villi into the intervillus space. The lack of terminal dilation and ...
Further information: Paternal age, Maternal age effect, and Pregnancy over age 50 ... The most common causes of maternal mortality are maternal bleeding, maternal sepsis and other infections, hypertensive diseases ... Caused by: Unknown, but risk factors include smoking, advanced maternal age, and prior surgery or trauma to the fallopian tubes ... Bayrampour, Hamideh; Heaman, Maureen (September 2010). "Advanced maternal age and the risk of cesarean birth: a systematic ...
Maternal age at first birth is a highly heritable trait. Human evolution continues during the modern era, including among ... They found that selection favored younger age at first birth among women. In particular, the average age at first birth of ... Around 60,000 years ago, during the middle of an ice age, it was extremely cold in the far north, but ice sheets sucked up much ... The most recent Ice Age peaked in intensity between 19,000 and 25,000 years ago and ended about 12,000 years ago. As the ...
Nybo Andersen AM, Wohlfahrt J, Christens P, Olsen J, Melbye M (June 2000). "Maternal age and fetal loss: population based ... Miscarriage rates increase steadily with age, with more substantial increases after age 35. In those under the age of 35 the ... Risk begins to increase around the age of 30. Paternal age is associated with increased risk. Not only is obesity associated ... In those under the age of 35 the risk is about 10% while it is about 45% in those over the age of 40. Risk begins to increase ...
Aged 11, he began using his maternal surname Shih (施; Shī; Si). After graduating from Waseda University in Tokyo with a degree ... Su died of pneumonia and multiple organ failure at Taipei Medical University Hospital on 20 September 2019, aged 100. He first ...
However, the maternal age, weight, ethnicity etc. are still included. In the UK the double test is part of the combined test ... The screening test carries a much lower risk to the fetus, however, and in conjunction with the age-related risk of the patient ... Spencer K, Liao AW, Ong CY, Flack NJ, Nicolaides KH (2001). "Maternal serum activin A and inhibin A in trisomy 18 pregnancies ... Many of these factors affect the levels of the substances being measured and the interpretation of the results: As maternal ...
Although she was her father's only legitimate child, Margaret had two maternal half-brothers and three maternal half-sisters ... Rosemary O'Day (26 July 2012). The Routledge Companion to the Tudor Age. Routledge. p. 5. ISBN 978-1-136-96253-0. .. ... At age twelve Margaret married Edmund Tudor, twelve years her senior, on 1 November 1455. The Wars of the Roses had just broken ... Ward, Jennifer C. (1992). English Noblewomen in the Later Middle Ages. University of California: Longman. p. 102.. ...
Environmental factors refer for example to maternal smoking and the maternal exposure to amine-containing drugs. Several ... Most surgeons will not intervene until after the age of six months due to the heightened risk which blood loss poses before ... this age.[42] It is generally preferable to wait until after three months of age when anaesthetic risks will also be decreased. ... Källén K (September 1999). "Maternal smoking and craniosynostosis". Teratology. 60 (3): 146-50. doi:10.1002/(SICI)1096-9926( ...
At age seven Ruth began to write short verses and read any book she could get her hands on. Her favorite author was Jean ... New York to the farm of Ruth's maternal grandparents, the Shattucks.[4] A year later he died, ten days after returning from a ... Although Ruth Benedict's fascination with death started at an early age, she continued to study how death affected people ... September 17, 1948(1948-09-17) (aged 61). New York City, New York, U.S.. ...
Late Middle AgesEdit. Further information: Late Middle Ages and Pomerania during the Late Middle Ages ... which permitted maternal inheritance with no precedence for female rule; (2) the insanity of Charles's mother, Joanna of ... Early Middle AgesEdit. Carolingian periodEdit. Main article: Carolingian Empire. As Roman power in Gaul declined during the 5th ... Innes, Matthew (24 April 2000). State and Society in the Early Middle Ages: The Middle Rhine Valley, 400-1000. pp. 167-70. ISBN ...
... such as increasing age, female gender, and genetics.[10] Obesity is more common in women than men in many parts of Africa.[29] ... "Maternal micronutrient deficiency, fetal development, and the risk of chronic disease". The Journal of Nutrition. 140 (3): 437 ... Typically it begins in middle or older age,[6] although rates of type 2 diabetes are increasing in young people.[19][20] Type 2 ... This increase is believed to be primarily due to the global population aging, a decrease in exercise, and increasing rates of ...
Tzaphlidou M (2004). «The role of collagen and elastin in aged skin: an image processing approach». Micron. 35 (3): 173-7. PMID ... 2010). «Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous ...
This maternal vocalization is highly attractive to their young. The repetition and frequency modulation of these quacks form ... Mallards of all ages (but especially young ones) and in all locations must contend with a wide diversity of predators including ... Dyer, Antoinette B.; Gottlieb, Gilbert (1990). "Auditory basis of maternal attachment in ducklings (Anas platyrhynchos) under ... during the Neolithic Age, and were also farmed by the Romans in Europe, and the Malays in Asia.[127] As the domestic duck and ...
"BBC Advice - Age Of Consent". BBC.. *^ "Prince Andrew under renewed pressure to speak about 'sex abuse' claims after flight ... His godparents were: the Duke of Gloucester (his maternal great-uncle); Princess Alexandra of Kent (his first cousin once ... which is above the age of consent in the United Kingdom[86]), and again in New York (where the age of consent is 17). Flight ... "Gordonstoun turns back clock to a golden age of cold showers (but would Prince Charles agree?)". The Scotsman. 28 April 2009. ...
... usually improves around the age of 20 but may persist into adulthood.[75] Permanent physical scarring may occur.[20] There ... Approximately 160 babies were born with birth defects due to maternal use of isotretinoin during pregnancy.[186][187] ... Historical and physical clues that may suggest hormone-sensitive acne include onset between ages 20 and 30; worsening the week ... Medical authorities strictly regulate isotretinoin use in women of childbearing age due to its known harmful effects in ...
Small for gestational age/Large for gestational age. *Preterm birth/Postmature birth ... Maternal factors and. complications of pregnancy,. labour and delivery. placenta:. *Placenta praevia ...
Nepal has made significant progress in improving maternal health. Maternal mortality rate was reduced from 748 per 100,000 live ... while the adults aged 15 years and above account for 92%. There are 3,385 infections estimated among population aged 50 years ... women of child bearing age, pregnant women, and all ages through the control of general malnutrition and the prevention and ... Neonatal and maternal tetanus was already eliminated on 2005 and Japanese encephalitis is in control status. Measles case based ...
Middle Ages[edit]. A manuscript of Al-Risalah al-Dhahabiah by Ali al-Ridha, the eighth Imam of Shia Muslims. The text says: " ... After the fall of the Western Roman Empire and the onset of the Early Middle Ages, the Greek tradition of medicine went into ... During the Middle Ages, the Catholic Church established universities which revived the study of sciences - drawing on the ... In China, archaeological evidence of medicine in Chinese dates back to the Bronze Age Shang Dynasty, based on seeds for ...
R&B and Soul Music, I just knew was what I really loved". He started writing songs at the age of nine after being given a ... He played football for the school team and Harmony Row Boys Club, his love of football probably inherited from his maternal ... At 16 years of age, whilst still at school, Miller had his first audition in the Manhattan Club, Bridgeton, Glasgow, and was ...
A wide range of age groups is affected, though the number of cases is highest among 10- to 19-year-olds. For unknown reasons, ... "Maternal Lyme borreliosis and pregnancy outcome". International Journal of Infectious Diseases. 14 (6): e494-8. doi:10.1016/j. ... Doxycycline is contraindicated in children younger than eight years of age and women who are pregnant or breastfeeding;[23] ...
Carroll QB (2014). Radiography in the Digital Age (2nd ed.). Springfield: Charles C Thomas. p. 9. ISBN 9780398080976. .. ...
3 years of age. Rehabilitation Inability to ingest food. Inability to eat food easily. Common. Common. 3 years of age. ... In these cases, the disorder is typically inherited from the maternal parent. Because RPS6KA3 is located on the X chromosome, ... 2 years of age. Progressive. Sensorineural deafness. Hearing Loss. Most common. Least common. No cure; can utilize cochlear ... 3 years of age. Rehabilitation Long-lasting wheezing. Coughs accompanied with a whistling sound from the chest that lasts long ...
In this context, "carryover" is not the same as excess supply or "surplus". Rice stocks were typically aged for at least two or ... which in turn reduced maternal deaths.[216] ... Das suggests that a large proportion of the girls aged 15 and ... The mortality statistics present a confused picture of the distribution of deaths among age and gender groups. Although very ... A relatively lower death rate for females of child-bearing age may have reflected a reduction in fertility, brought on by ...
Selectional pleiotropy occurs when the resulting phenotype has many effects on fitness (depending on factors such as age and ... This, however, is not observed in nature, and thus antagonistic pleiotropy contributes to the slow deterioration with age ( ...
Franklin-Brown, Mary (2012). Reading the world : encyclopedic writing in the scholastic age. Chicago London: The University of ... The degree of viviparity varies; some species simply retain the eggs until just before hatching, others provide maternal ... known as the Age of Reptiles).[43] One of the best known early stem-reptiles is Mesosaurus, a genus from the Early Permian that ... "Age of Reptiles". The dinosaurs also developed smaller forms, including the feather-bearing smaller theropods. In the ...
the age(melbourne)magazine, p. 16 *^ Hong, Yu-Hung (March 1999). "Myths and Realities of Public Land Leasing: Canberra and Hong ... Gorton spent his early years living with his maternal grandparents in Port Melbourne, as his parents were frequently away on ... Gorton died at Sydney's St Vincent's Hospital at the age of 90 in May 2002.[89] A State funeral[90] and memorial service was ... He endorsed Hewson's Fightback! package.[87] In his old age he was rehabilitated by the Liberals; his 90th birthday party was ...
Boynton, Dori, compiler (1991). Lady Boynton's "New Age" Dossiers: a Serendipitous Digest of News and Articles on Trends in ... Studies have shown that by combining live music, such as harp music, with the Kangaroo Care, maternal anxiety is reduced. This ... "Age in Action. 29 (3): 1-5.. *Pellizzari, Patricia y colaboradores: Flavia Kinisberg, Germán Tuñon, Candela Brusco, Diego ... on New Age aspects of speculation in psychology, philosophy, music (especially music therapy), religion, sexuality, etc. ...
... which would seem to be partly equivalent to the Astral Plane of popular occultism and New Age thought. ... Rajnarayan Basu (Maternal grandfather). *Manmohan Ghose (Elder brother). *Barin Ghosh (Younger brother) ... With time once the rationalistic age took over and speculation began the Indian philosophers recognised that the vedantic texts ...
This name uses Spanish naming customs: the first or paternal family name is Santos and the second or maternal family name is ... 1984-03-01) 1 March 1984 (age 34). Place of birth. La Virgen del Camino, Spain. ...
Nurturant maternal care, in turn, may enhance HPA functioning in at least two ways. First, maternal care is crucial in ... Spencer RL, Hutchison KE (1999). "Alcohol, aging, and the stress response". Alcohol Research & Health. 23 (4): 272-83. PMID ... Thus, if a developing child (i.e., fetus to neonate) is exposed to ongoing maternal stress and low levels of maternal care (i.e ... maternal stress, and postnatal - i.e. maternal care), and later-life environment (which determines match/mismatch, as well as a ...
"Country Comparison :: Maternal Mortality Rate". The World Factbook. CIA.gov. Archived from the original on 18 April 2015. ... among adults aged 15-49 years.[105] ... Ivory Coast has the 27th-highest maternal mortality rate in the ...
Weng HH, Bastian LA, Taylor DH, Moser BK, Ostbye T. Number of children associated with obesity in middle-aged women and men: ... Effects of interventions in pregnancy on maternal weight and obstetric outcomes: meta-analysis of randomised evidence. BMJ ( ... Borodulin K, Laatikainen T, Juolevi A, Jousilahti P. Thirty-year trends of physical activity in relation to age, calendar time ... Prospective study of intentional weight loss and mortality in never-smoking overweight US white women aged 40-64 years. Am. J. ...
At the age of 17, Aldo moved from Manaus to Rio de Janeiro having only his clothes with him and determination to train mixed ... This name uses Portuguese naming customs: the first or maternal family name is da Silva and the second or paternal family name ... Known by the nickname "Junior", José Aldo da Silva Oliveira Júnior fought his first professional MMA fight at the age of 17 at ...
P.S. Our legal system still works!"[147] The gender gap has partly been explained by "the maternal instinct". The idea of a ... and would also stipulate a time frame for notification of the disappearance of a young child under the age of 12.[194][196] The ... While we don't know what is true and maybe never will, it is worth taking a look at the narcissistic family when maternal ... and her maternal grandparents, George and Cindy Anthony. On July 15, 2008, she was reported missing in a 9-1-1 call made by ...
Grenz, Stanley J.; Olson, Roger E. (1997). 20th-Century Theology: God & the World in a Transitional Age. Downers Grove, IL: ... "maternal" attributes such as nurturing, acceptance, and creativity. ... Lewis, James R. (1992). Perspectives on the New Age. SUNY Press. pp. 16-18. ISBN 978-0-7914-1213-8. .. ... I pray to you to accept me as your husband and live with me until our old age. ..." Rigveda Samhita Part -4, sukta 85, sloka ...
On 13 August 1910, at the age of 90, she died peacefully in her sleep in her room at 10 South Street, Mayfair, London.[47][48] ... Fanny's father (Florence's maternal grandfather) was the abolitionist and Unitarian William Smith.[10] Nightingale's father ... "Miss Nightingale Dies, Aged Ninety". The New York Times. 15 August 1910. Retrieved 21 July 2007. Florence Nightingale, the ... Florence Nightingale exhibited a gift for mathematics from an early age and excelled in the subject under the tutelage of her ...
Source for information on Maternal Age: Child Development dictionary. ... Age at the time of delivery of less than sixteen years or greater than thirty-five years meets the criteria for this definition ... MATERNAL AGEExtremes of maternal age are associated with adverse outcomes in pregnancy. ... MATERNAL AGE. Extremes of maternal age are associated with adverse outcomes in pregnancy. Age at the time of delivery of less ...
... gestational diabetes and pre-eclampsia are higher in advanced maternal age than in younger expectant mothers. ... Advanced maternal age refers to women giving birth at the age of over 35. In the western world, advanced maternal age has been ... The age of over 35 as such was not a significant independent risk factor, but the risks increased when advanced maternal age ... The association between maternal age and risks and birth outcomes is a topic on which plenty of research has been carried out; ...
Education of contraception, safe sex and effective care during pregnancy of both extremely maternal age groups should be ... The patient data includeing demographic data, hospital course, maternal laboratory investigations, maternal complications, ... Conclusion: Adverse maternal and neonatal outcomes were mostly found in the pregnant women ≤ 16 and ≥ 40 years. ... Adverse Pregnancy Outcome; Extremely Maternal Age; Young Maternal Age; Advanced Maternal Age ...
... gestational age, and maternal body mass index, weight gain, and systolic bp. Conclusions. Higher maternal age was associated ... Maternal age and newborn blood pressure. Matthew W Gillman, Carol L Link, Janet W Rich-Edwards, Ellice S Lieberman, Steven E ... Maternal age and newborn blood pressure. Matthew W Gillman, Carol L Link, Janet W Rich-Edwards, Ellice S Lieberman and Steven E ... Maternal age and newborn blood pressure. Matthew W Gillman, Carol L Link, Janet W Rich-Edwards, Ellice S Lieberman and Steven E ...
The journal welcomes submissions on breastfeeding, labor, maternal health and the biomedical aspects of pregnancy. ... Maternal age was a significant effect modifier; therefore, results were stratified by maternal age. Multinomial logistic ... Sociodemographic factors included maternal age (,20; 20-24; 25-29; 30-34; ≥ 35), maternal race/ethnicity (White; Black; ... Prepregnancy Depression and Breastfeeding Duration: A Look at Maternal Age. Jordyn T. Wallenborn, Anny-Claude Joseph, Whitney C ...
Maternal support in early childhood predicts larger hippocampal volumes at school age. Joan L. Luby, Deanna M. Barch, Andy ... Maternal support observed in early childhood was strongly predictive of hippocampal volume measured at school age. The positive ... Maternal support in early childhood predicts larger hippocampal volumes at school age ... Maternal support in early childhood predicts larger hippocampal volumes at school age ...
This exploration of the Irish pattern points to broader generalizations about all womens lives during the Gilded Age. This ... This article argues that womens different maternal strategies and styles of mothering better explain ethnic patterns of female ...
Thus, to assess the true effects of maternal age, researchers need an inclusive set of narrowly defined age-groups spanning all ... Maternal Age and Birth Outcomes: Data from New Jersey. Nancy E. Reichman. Deanna L. Pagnini. ... 11. D. Strobino et al., "Mechanisms for Maternal Age Differences in Birth Weight," American Journal of Epidemiology, 142:504- ... 8. D.C. La Grew, Jr., et al., "Advanced Maternal Age: Perinatal Outcome when Controlling for Physician Selection," Journal of ...
1 in 1,383 At age 30, 1 in 959 At age 35, 1 in 338 At age 40, 1 in 84 At age 45, 1 in 32 Advanced maternal age is associated ... Advanced maternal age, in a broad sense, is the instance of a woman being of an older age at a stage of reproduction, although ... Finally, although older maternal age doesnt necessarily imply older paternal age, researchers have suggested links between ... In the U.S., the average age of first childbirth was 26.9 in 2018. Advanced maternal age is associated with adverse ...
... accelerating the rate of aging of metabolic problems that occur in normal life. ... The effects of maternal obesity even pass across generations to offspring, ... uw-researcher-shows-that-maternal-obesity-speeds-up-aging-in-offspring.. html Related Journal Article. http://dx.. doi.. org/ ... Another study found that the child of a slightly undernourished mother is more likely to suffer early aging of the heart. ### ...
... Offspring of obese mothers more susceptible to diabetes. University of ... Another study found that the child of a slightly undernourished mother is more likely to suffer early aging of the heart. ... New research shows that the effects of maternal obesity even pass across generations to offspring, accelerating the rate of ... They observed the offspring throughout their lives - puberty, early adult life, late adult life and early aging - to determine ...
This study aimed to determine if maternal age is associated with preschool immunization coverage and the importance of maternal ... age compared with other factors affecting vaccination coverage. Data from the 2001-2003 N … ... Associations between maternal age and preschool immunization coverage are unclear. ... After 26 years of age, coverage did not increase significantly as maternal age increased. The relationship between maternal age ...
Maternal weight gain during pregnancy and child weight at age 3 years.. Olson CM1, Strawderman MS, Dennison BA. ... in offspring at age 3 years and if its influence varies by maternal BMI. ... Reducing maternal BMI in the preconception period in overweight women and preventing excessive weight gain in pregnancy for all ... Excess pregnancy weight gain is associated with increased risk of child overweight at age 3 years and its impact is greater ...
Breastfeeding and lung function at school age: does maternal asthma modify the effect?. Dogaru CM1, Strippoli MP, Spycher BD, ... To explore the association between breastfeeding and school-age lung function.. METHODS: In the Leicestershire Cohort Studies ... and skin prick tests were measured at age 12 years. We performed multivariable linear regression and tested potential causal ... in particular whether the effect is modified by maternal asthma. ...
I use an exogenous source of variation in maternal net earning opportunities, generated through school entrance age of children ... To deal with the endogeneity of school attendance age, I exploit the variation in child month of birth and state kindergarten ... The estimates suggest that delayed school enrollment has long run implications for maternal labor supply. Results point towards ... I estimate the effect of a one year delay in school attendance on long run maternal labor supply. ...
... Toyota plans to sell Kirobo Mini, which blinks its eyes ... Toyotas non-automotive venture aims to tap a demographic trend that has put Japan at the forefront of aging among the worlds ... Exacerbated by a reluctance to invite immigrants to bolster its working-age population, Japans demographic crunch shows little ...
While some of the highest maternal exposures to polycyclic aromatic hydrocarbons (PAHs) occur in the workplace, there is only ... After adjustment for maternal age, there was a significant association of occupational exposure with SGA (OR=2.2, 95% CI 1.3 to ... Maternal occupational exposure to polycyclic aromatic hydrocarbons and small for gestational age offspring.. ... Small for gestational age (SGA) was the only adverse pregnancy outcome with enough exposed cases to yield meaningful results. ...
Pregnant and over age 35? Read up on what to expect during pregnancy, including the possible risks you may face during each leg ... Moms of all ages come in all shapes and sizes-but women of advanced maternal age are statistically more likely to be overweight ... The risk of genetic abnormalities in baby is higher in women of advanced maternal age. "Women dont make new eggs as they age, ... but it will likely take longer for women of advanced maternal age to get pregnant. "Fertility in women starts to decline at age ...
Paternal age and maternal age are risk factors for miscarriage; results of a multicentre European study. Hum Reprod2002;17:1649 ... We can show that maternal smoking does not contribute to the associations, but we lack information on paternal age, maternal ... The risk of miscarriage was lowest in women aged 25-29 (10%), and rose rapidly after age 30, reaching 53% in women aged 45 and ... Maternal age and fetal loss: population based register linkage study. BMJ2000;320:1708-12. doi:10.1136/bmj.320.7251.1708. pmid: ...
Young Maternal Age and Poor Child Development: Predictive Validity From a Birth Cohort. Catherine R. Chittleborough, Debbie A. ... Model discrimination was poor using maternal age only (area under the receiver operator characteristic curve ∼0.5 for all 3 ... Young Maternal Age and Poor Child Development: Predictive Validity From a Birth Cohort ... Young Maternal Age and Poor Child Development: Predictive Validity From a Birth Cohort ...
Advanced maternal age (AMA) is defined as age 35 years and older at the estimated date of delivery. Objective: The aim of this ... Maternal risks associated with pregnancy in women with advanced maternal age. en_GB. ... Significant difference was found between maternal age and BMI (p , 0.0001), maternal smoking status (p , 0.0001), non-insulin ... Maternal risks associated with pregnancy in women with advanced maternal age. Malta Medical Journal, 30(2), 5-13.. en_GB. ...
Alternate Text: The figure above shows birth rates among women aged 15-44 years, by maternal age group, in the United States ... QuickStats: Birth Rates* Among Women Aged 15-44 Years, by Maternal Age Group - National Vital Statistics System, United States ... The birth rate for women aged 25-29 years decreased 9% (to 107.2), and the rate for women aged 30-34 years decreased 6% (to ... The birth rate for women aged 25-29 years decreased 9% (to 107.2), and the rate for women aged 30-34 years decreased 6% (to ...
We consider an age-structured epidemiological model that accounts for both passively acquired maternal antibodies that decay ... system with aging from one age-group to the next. We derive formulae for the effective reproduction number ${\mathcal R}$ and ... The model is a 6-dimensional system of partial differential equations (PDE). By assuming constant rates within each age-group, ... Computation of $\mathcal R $ in age-structured epidemiological models with maternal and temporary immunity. Zhilan Feng 1, , ...
We measured maternal depressive symptoms using the Edinburgh Postnatal Depression Scale (EPDS), a self-report measure validated ... We examined the association of prenatal depressive symptoms at mid-pregnancy with child cognition at age 3 years in Project ... Association of maternal prenatal depressive symptoms with child cognition at age 3 years. ... Association of maternal prenatal depressive symptoms with child cognition at age 3 years. Paediatric and Perinatal Epidemiology ...
... by most obstetricians for being of advanced maternal age, over 35 years old. Advanced maternal age is a well known risk factor ... Advanced maternal age may be linked to decreased congenital malformations.. February 13, 2014. by Jodi Selander ... Filed Under: birth, Health, Mothering, Research, Uncategorized Tagged With: advanced maternal age, articles, babies, Health, ... According to a new study, advanced maternal age might not be as risky as some may believe. In fact, it may actually decrease ...
The aim of this study was to evaluate the influence of maternal anemia on the infants iron status at 9... ... The aim of this study was to evaluate the influence of maternal anemia on the infants iron status at 9 months of age in ... Impact of Maternal Anemia on the Infants Iron Status at 9 Months of Age. ... Singla PN, Tyagi M, Kumar A, Dash D, Shankar R. Fetal growth in maternal anemia. J Trop Pediatr 1997;43:89-92.CrossRefGoogle ...
... also exhibits a paternal age effect due to the paternal origin o ... are known to be associated with advanced paternal age, and it ... The modeling strategy evaluated effects of continuous increasing maternal and paternal age and 5-year age increases adjusted ... Mean maternal ages for survivors classified as having de novo germline mutations and sporadic Rb were similar (28.3 and 28.5, ... In contrast, maternal and paternal ages for familial Rb did not differ significantly from the weighted US general population ...
At 12 months of postnatal age, child competencies (development and behavior) were assessed, together with maternal adjustment ( ... Preterm behavior, maternal adjustment, and competencies in the newborn period: What influence do they have at 12 months ... The behavioral competencies of 42 well, singleton preterm infants (mean gestational age=31 weeks) were assessed, as were their ... Regression analyses indicated that in the newborn period, maternal positive reappraisal and a planful coping style, more ...
Advanced maternal age was defined as ≥32 years and a reference group of women aged 25-31 years was used for comparisons. The ... SJ McCall, M Nair, M Knight, Factors associated with maternal mortality at advanced maternal age: a population-based case- ... Associations between advanced maternal age and psychological distress in primiparous women, from early pregnancy to 18 months ... Objective To investigate if advanced maternal age at first birth increases the risk of psychological distress during pregnancy ...
Woman is age 35 & above at expected date of delivery.. *As maternal age increases, risks of birth defects increase. *Women do ... Advanced maternal age begins at 35 years of age because a womans risk of having a child with a chromosomal difference at 35 is ... Handbook of Genetic Counseling/Trisomy 13 - Advanced Maternal Age - Occupational Exposures. From Wikibooks, open books for an ... It remains to be shown whether a true increased risk, taking maternal age into account, really exists ...
  • The findings were originally published in BMC Pregnancy and Childbirth , BMC Public Health , and Journal of Maternal-Fetal and Neonatal Medicine . (eurekalert.org)
  • Advanced maternal age continues to be associated with a range of adverse pregnancy outcomes including low birth weight, pre-term birth, stillbirth, unexplained fetal death, and increased rates of Caesarean section. (wikipedia.org)
  • We evaluated the CARdiac disease in PREGnancy (CARPREG) and modified World Health Organization (mWHO) risk classifications for cardiac complications during pregnancies in women with congenital heart defects and analyzed the impact of age on risk of obstetric and fetal outcome. (gu.se)
  • Everyone, including my co-authors, were a little surprised at the findings," Goetzinger told MedPage Today at the annual meeting of the Society of Maternal-Fetal Medicine where the study results were presented. (medpagetoday.com)
  • If a woman is thinking of getting pregnant and is over the age of 35, and particularly if she has underlying health issues, it's prudent to seek medical counseling prior to getting pregnant to optimize her health," says Kecia Gaither , MD, MPH, FACOG, a maternal fetal medicine specialist and director of perinatal services at NYC Health +Hospitals/ Lincoln. (thebump.com)
  • As a result of the ovarian reserve starting to decrease, the body starts signaling the ovaries to release more eggs, so mothers closer to the age of 40 have a higher chance of conceiving multiples naturally," explains Adeeb Khalifeh, MD, a maternal fetal medicine specialist at Einstein Medical Center Philadelphia. (thebump.com)
  • The number one factor is really health," says Kecia Gaither, M.D., maternal fetal medicine specialist and director of perinatal outreach at Montefiore Medical Center in New York City. (fitpregnancy.com)
  • Implantation rate was defined as the percentage of fetal heart beat among total transferred embryos at 12 weeks' gestational age. (clinicaltrials.gov)
  • CONCLUSIONS: Fetal exposure to high maternal glucose concentration in the absence of pre-existing diabetes or GDM may contribute to the development of overweight/obesity in the offspring, independent of maternal prepregnancy BMI. (unc.edu)
  • CONCLUSIONS Antepartum maternal glucose metabolism was significantly associated with fetal hyperinsulinemia and excessive fetal growth in relatively nonobese Korean women. (diabetesjournals.org)
  • Maternal sex hormones in pregnancy can theoretically influence the developing fetal immune system and modulate the subsequent development of atopic disorders. (bmj.com)
  • In particular, exposure of the immature fetal immune system to excessive maternal oestrogen has been postulated to be associated with the subsequent development of atopy in the offspring. (bmj.com)
  • Downregulated expression of PlGF may cause placental vascular insufficiency, resulting in placental dysfunctional complications including preeclampsia, fetal growth restriction, or its surrogate indicator, small for gestational age (SGA) ( 5 - 10 ). (frontiersin.org)
  • In a study published in Translational Psychiatry, researchers report that 23% of all cases of autism may result from the presence of maternal antibodies that interfere with fetal brain development during pregnancy. (ageofautism.com)
  • the pro-inflammatory cytokine interleukin 6, which is known to induce placental inflammatory processes46 and has been shown to mediate the neurodevelopmental effects of gestational inflammation.47 It is possible that such inflammatory processes could be related to the production of maternal antibodies that recognize fetal antigens through maternal-fetal cross talk48 or that maternal antibody to antigen interactions may precipitate inflammation-induced neurodevelopmental alterations similarly to bacterial or viral challenge. (ageofautism.com)
  • With the arrival of electronic patient records, advanced computational methods, the widespread use of machine learning tools, and, more recently, of deep learning strategies, we are just beginning to harness the power of the complex information contained in routinely collected maternal-fetal data. (frontiersin.org)
  • As highly relevant, we also welcome insights from maternal-fetal data in the antepartum period as well as neurological development in children from birth on and long past the first years of life. (frontiersin.org)
  • ConclusionsIn maternal type 1 diabetes pregnancies, fetal cardiovascular hemodynamics is impaired. (medworm.com)
  • Background: There is growing evidence that maternal obesity and prenatal exposure to a high-fat diet program fetal development to regulate the physiology and behavior of the offspring in adulthood. (ebscohost.com)
  • Fretts RC, Schmittdiel J, McLean FH, Usher RH, Goldman MB (1995) Increased maternal age and the risk of fetal death. (springer.com)
  • The authors investigated the influence of other maternal and fetal factors on heart block development in a Swedish population-based cohort. (diva-portal.org)
  • METHODS: The influence of fetal gender, maternal age, parity and time of birth on heart block development was analysed in 145 families, including Ro/La-positive (n=190) and Ro/La-negative (n=165) pregnancies. (diva-portal.org)
  • In pregnant women, what is the extent of risk from maternal age for fetal death (spontaneous abortion, ectopic pregnancy, or stillbirth)? (acpjc.org)
  • The analysis for the combined effect of maternal age and reproductive history on fetal death was limited to reproductive outcomes between 1988 and 1992. (acpjc.org)
  • Background: Observational epidemiological studies indicate that maternal height is associated with gestational age at birth and fetal growth measures (i.e., shorter mothers deliver infants at earlier gestational ages with lower birth weight and birth length). (uib.no)
  • This study aimed to investigate the casual relationships behind the strong association of maternal height with fetal growth measures (i.e., birth length and birth weight) and gestational age by a Mendelian randomization approach. (uib.no)
  • Their association with the maternal nontransmitted haplotype score was far less significant, indicating a major fetal genetic influence on these fetal growth measures. (uib.no)
  • Conclusions: Our results demonstrate that the observed association between maternal height and fetal growth measures (i.e., birth length and birth weight) is mainly defined by fetal genetics. (uib.no)
  • The three most positive affecting factors for the baby are a mother's social support, maternal-fetal attachment and high self-esteem. (wikipedia.org)
  • Extremes of maternal age are associated with adverse outcomes in pregnancy. (encyclopedia.com)
  • Maternal Youth and Pregnancy Outcomes: Middle School versus High School Age Groups Compared to Women beyond the Teen Years. (encyclopedia.com)
  • Conclusion: Adverse maternal and neonatal outcomes were mostly found in the pregnant women ≤ 16 and ≥ 40 years. (scirp.org)
  • Education of contraception, safe sex and effective care during pregnancy of both extremely maternal age groups should be implemented to reduce those poor outcomes. (scirp.org)
  • Chawanpaiboon, S. and Hengrasmee, P. (2013) Adverse pregnancy outcomes in extremely maternal age. (scirp.org)
  • Although these current practices align with national targets (81.9% and 25.5%, respectively) [ 1 ], present disparities minimize the protective effects of breastfeeding on maternal and infant health outcomes. (hindawi.com)
  • The seemingly poorer birth outcomes of teenage mothers appear to result largely from their adverse socioeconomic circumstances, not from young maternal age per se. (guttmacher.org)
  • Research has documented that teenage mothers are at high risk for poor birth outcomes: Babies born to teenagers are more likely than those born to women in their 20s to be born early, to weigh less than 2,500 g at birth or to die before age one. (guttmacher.org)
  • Further research suggests that these risks vary by age even among teenage mothers, with those younger than 15 having the worst outcomes. (guttmacher.org)
  • Teenagers are not the only age-group at high risk for poor birth outcomes, but they have received the most public attention. (guttmacher.org)
  • On the other end of the age spectrum, while women who give birth relatively late in their reproductive lives have fewer socioeconomic disadvantages than teenagers, they nonetheless share increased risks for poor birth outcomes. (guttmacher.org)
  • Interestingly, some of the unwanted outcomes resulting from maternal obesity were different in male and female offspring. (eurekalert.org)
  • Encouragingly, exercise by the offspring improves many of the poor offspring outcomes that result from maternal obesity. (eurekalert.org)
  • Outcomes of 496 pregnancies in 232 women, including induced abortion, miscarriage, stillbirth, and live birth were analyzed regarding complications, maternal age, mode of delivery, and two risk classifications: CARPREG and mWHO. (gu.se)
  • Study limitations included the retrospective design, data from a referral population, lack of paternal age, and rare outcomes, making it difficult to pin down the exact cause or reason for the findings, Goetzinger stated. (medpagetoday.com)
  • Maternal age and adverse pregnancy outcomes: a cohort study. (biomedsearch.com)
  • OBJECTIVE: The aim of this study was to examine the association between maternal age and a wide range of adverse pregnancy outcomes after adjustment for confounding factors in obstetric history and maternal characteristics. (biomedsearch.com)
  • Data on maternal characteristics, medical and obstetric history were collected and pregnancy outcomes ascertained. (biomedsearch.com)
  • Regression analysis was performed to examine the association between maternal age and adverse pregnancy outcomes including preeclampsia (PE), gestational hypertension (GH), gestational diabetes mellitus (GDM), preterm delivery (PTD), small for gestational age (SGA), large for gestational age (LGA), miscarriage, stillbirth, elective and emergency cesarean section (CS). (biomedsearch.com)
  • Objectives: While some of the highest maternal exposures to polycyclic aromatic hydrocarbons (PAHs) occur in the workplace, there is only one previous study of occupational PAH exposure and adverse pregnancy outcomes. (cdc.gov)
  • Conclusions The risk of miscarriage varies greatly with maternal age, shows a strong pattern of recurrence, and is also increased after some adverse pregnancy outcomes. (bmj.com)
  • We aimed to examine the ability of mother's age, and other factors measured during pregnancy (education, financial difficulties, partner status, smoking, and depression), to predict child development outcomes up to age 5 years. (aappublications.org)
  • Model discrimination was poor using maternal age only (area under the receiver operator characteristic curve ∼0.5 for all 3 outcomes). (aappublications.org)
  • Objective: The aim of this large retrospective cohort study is to assess for the association between AMA and adverse maternal outcomes after adjustment for confounding factors in maternal characteristics and in the obstetric history. (edu.mt)
  • Regression analysis revealed persistent significant differences between maternal age and different maternal outcomes. (edu.mt)
  • Care providers need to be aware of these increased risks and adjust their obstetric management according to the individual to ensure optimal maternal outcomes. (edu.mt)
  • Child cognitive and behavioural outcomes were evaluated using the Bayley Scales of Infant Development (II) and the Child Behavior Checklist for Ages 1.5-5. (nih.gov)
  • There were no significant differences in mean age of menarche between mothers of children with and without each of the primary outcomes. (bmj.com)
  • Further evidence of an effect of age of menarche on atopic outcomes came from a large epidemiological study in Denmark in which early onset menarche was associated with an increased risk of allergic rhinitis in adult women. (bmj.com)
  • Infant outcomes in the study will be measured with gestational age and birthweight. (clinicaltrials.gov)
  • In addition to develop a modified TaiChi exercise program suitable for pregnant women, the study anticipates that maternal stress, fatigue, and poor sleep quality can predict infant outcomes through immunologic pathway, and the modified TaiChi exercise can reduce maternal stress and fatigue, improve sleep quality, modulate biomarkers, and hence prevent adverse infant outcomes. (clinicaltrials.gov)
  • This is a retrospective cohort study on maternal and neonatal outcomes of the twin pregnancies of 57 women aged ≥45 years compared to 114 younger women who gave birth in our institution between January 2011 and August 2015. (ovid.com)
  • We conclude that women older than 45 years with twin pregnancies have higher maternal and perinatal complications with worse outcomes in comparison with younger women. (ovid.com)
  • This past year, our group at the Center for Women's Mental Health collaborated with Dr. Charles Nelson at Boston Children's Hospital after being awarded a NARSAD grant to study the long term neurobehavioral outcomes for children ages 6 to 17 born to bipolar mothers who were followed during their pregnancies in a previous study. (womensmentalhealth.org)
  • Maternal folate, vitamin B-12, and vitamin B-6 concentrations during pregnancy have been shown to influence birth outcomes, but the evidence is inconclusive. (sigmaaldrich.com)
  • Objectives: To evaluate the associations between maternal age and obstetric and neonatal outcomes in primiparous women with emphasis on teenagers and older women. (diva-portal.org)
  • Women with advancing age (greater than= 30 years) revealed significantly increased risk of prematurity, perineal lacerations, preeclampsia, abruption, placenta previa, postpartum haemorrhage and unfavourable neonatal outcomes compared with the reference group. (diva-portal.org)
  • Conclusions: For clinicians counselling young women it is of importance to highlight the obstetrically positive consequences that fewer maternal complications and favourable neonatal outcomes are expected. (diva-portal.org)
  • The results imply that there is a need for individualising antenatal surveillance programmes and obstetric care based on age grouping in order to attempt to improve the outcomes in the age groups with less favourable obstetric and neonatal outcomes. (diva-portal.org)
  • Gestational age was more strongly associated with adverse perinatal and maternal outcomes than maternal age, but the difference was non‐significant. (medworm.com)
  • Further research is needed to understand the determinants and management of dysfunctional labor in older women to help design strategies for reducing population cesarean delivery rates without adversely affecting maternal and infant outcomes. (naturalremediescures.com)
  • Although maternal obesity did not change the offspring's behavioral response to chronic stress per se, we demonstrate that the behavioral outcomes induced by prenatal exposure to maternal obesity parallel the deleterious effects of adult chronic stress exposure in aged male mice. (ebscohost.com)
  • Advanced maternal age at birth is considered a major risk factor for birth outcomes. (lse.ac.uk)
  • Advanced maternal age is associated with a marked elevation in the risk of different pregnancy complications and adverse pregnancy outcomes. (springer.com)
  • Evidence exists that maternal depression in the perinatal period has an adverse effect on a range of early childhood outcomes and increases the risk of offspring depression during adolescence. (onmedica.com)
  • We used biprobit regression to model the association between maternal antenatal depression and the two offspring outcomes (psychotic experiences and depression) at 18 years of age jointly.3067 offspring for whom data were available on maternal perinatal depression and offspring psychotic experiences aged 18 years were included in analyses. (onmedica.com)
  • Maternal age at conception and reproductive history (parity and reproductive outcomes in the past 10 years). (acpjc.org)
  • In addition, our approach that utilizes the genetic score derived from the nontransmitted maternal haplotype as a genetic instrument is a novel extension to the Mendelian randomization methodology in casual inference between parental phenotype (or exposure) and outcomes in offspring. (uib.no)
  • The effects of maternal age on low birth weight, newborns' hospital costs and infant mortality were estimated based on individual 1989 and 1990 vital statistics records from New Jersey that were linked with uniform billing hospital discharge records. (guttmacher.org)
  • New research shows that the effects of maternal obesity even pass across generations to offspring, accelerating the rate of aging of metabolic problems that occur in normal life. (eurekalert.org)
  • The present study examined the effects of maternal anxiety during infant hospitalization in the Neonatal Intensive Care Unit (NICU) on the child's cognitive and behavioural development at 24 months corrected age. (nih.gov)
  • The effects of maternal smoking on early mucosal immunity and sensitization at 12 months of age. (biomedsearch.com)
  • In this study, we examined the effects of maternal smoking as a major adverse exposure in early life, on mucosal immune function and allergen sensitization in the first year of life. (biomedsearch.com)
  • There were no effects of maternal smoking on the rates of allergen sensitization, atopic dermatitis and food allergy at 12 months of age. (biomedsearch.com)
  • DESIGN--Italian stillbirth data from 1955 to 1979 were analysed using a log-linear Poisson model with arbitrary constraints on the parameters to identify the effects of maternal birth cohort, calendar period of stillbirth and maternal age. (bmj.com)
  • We assessed the modifying effects of maternal PON1 -108 C/T and PON1 192 Q/R genotypes on relationships between prenatal OP exposure and developmental quotients (DQs) in 24-month-old children in Shandong, China ( n = 172). (springer.com)
  • According to an extensive, register-based study carried out at the University of Eastern Finland, the risks associated with overweight, smoking, gestational diabetes and pre-eclampsia are higher in advanced maternal age than in younger expectant mothers. (eurekalert.org)
  • The association between age and an additional risk factor on complications during pregnancy and the outcome of childbirth were studied in four risk groups: expectant mothers diagnosed with pre-eclampsia, expectant mothers who smoked, expectant mothers who were overweight and obese, and expectant mothers diagnosed with gestational diabetes. (eurekalert.org)
  • The outcome of childbirth in advanced maternal age was compared to the outcome of younger mothers, i.e. those under 35. (eurekalert.org)
  • In all of the four risk groups, the risks associated with pregnancy and childbirth were higher in advanced maternal age than in younger expectant mothers. (eurekalert.org)
  • In expectant mothers over 35 and diagnosed with pre-eclampsia, pre-term birth and small-for-gestational-age infant were a particular risk. (eurekalert.org)
  • In expectant mothers over 35 and who smoked, low birth weight, pre-term birth, foetal death and small-for-gestational-age infant were more likely than in younger expectant mothers. (eurekalert.org)
  • Furthermore, in expectant mothers over 35 who were overweight or obese and diagnosed with gestational diabetes, pre-term birth, foetal death, large-for-gestational-age infant and pre-eclampsia in particular were more likely. (eurekalert.org)
  • The highest newborn systolic bp was in children of the oldest mothers, and the lowest in the maternal age group 20-24 years ( ⇓ Table). (ahajournals.org)
  • Both black and white mothers in their 30s were significantly more likely to deliver a low-birth-weight baby than women aged 25-29 of the same race. (guttmacher.org)
  • There is a great deal of debate, however, about whether these consequences are due to maternal age per se, or whether they are caused by the adverse economic and social circumstances of teenagers who become mothers. (guttmacher.org)
  • Finally, we suggest escaping this DNA damage checkpoint in maternal ageing may be one of the causes of increased chromosome anomalies in oocytes and embryos from older mothers. (nature.com)
  • Only a small proportion of children with poor development had mothers aged younger than 20 years at their birth (3.3%, 6.4%, and 9.2%, for the ADS, SDQ, and SEA, respectively). (aappublications.org)
  • Even if programs targeted at teen-aged mothers are successful in improving child development, they will have little impact on population levels of poor child development if young maternal age is the sole or main means of identifying eligibility for the program. (aappublications.org)
  • The behavioral competencies of 42 well, singleton preterm infants (mean gestational age=31 weeks) were assessed, as were their mothers' adjustment (depression and coping) and competencies (knowledge of child development). (wiley.com)
  • Eighty-two mothers and their infants completed the 12-month follow-up period--56 in the maternal non-smoking group and 26 in the maternal smoking group. (biomedsearch.com)
  • Despite significant improvements in some maternal characteristics, the proportion of teenage pregnancies, preterm deliveries, low birthweight, and cesareans increased, raising concerns about the health costs and consequences for mothers and infants. (scielo.br)
  • In a recent study, Santucci and colleagues (2017) recruited 197 mother-infant dyads over the course of five years, which included 116 control infants born to mothers without bipolar disorder, 27 infants with exposure to maternal bipolar disorder but no psychotropic drug exposure (BD-), and 54 infants with exposure to maternal bipolar disorder and psychotropic drug exposure (BD+). (womensmentalhealth.org)
  • In this study, 32 mothers aged 35 years and older (case group) and 292 mothers aged 20-35 years (control group) were examined. (magiran.com)
  • The relationship between prenatal age of mothers and infant's anthropometric indices were calculated using the Pearson correlation coefficient. (magiran.com)
  • 37 weeks gestation), we compare between-family models (comparing children born to different mothers at different ages) with within-family models (comparing children who are born to the same mother at different ages). (lse.ac.uk)
  • In Finland, advanced maternal age is not independently associated with the risk of LBW and preterm birth among mothers who have at least two live births. (lse.ac.uk)
  • mothers aged 40-50: adjusted HR 0.73, 95% CI 0.36-1.46, p = 0.373). (springer.com)
  • Thus, increasing maternal choline intake during pregnancy may represent a safe and effective treatment approach for expectant mothers carrying a DS fetus, as well as a possible means of BFCN neuroprotection during aging for the population at large. (sigmaaldrich.com)
  • Offspring of mothers with complete data on maternal perinatal depression measures, and complete data on outcome (psychotic experiences) and confounding variables were included in the main analysis. (onmedica.com)
  • From joint modelling, there was no evidence that the association between maternal antenatal depression and offspring psychotic experiences differed in strength compared with offspring depression (p=0·19).The offspring of mothers who experience depression in the perinatal period are more likely to report psychotic experiences at 18 years of age. (onmedica.com)
  • Children of overweight and obese mothers, and children with higher birth weight, are more likely to be obese and overweight at age 5. (eurekamag.com)
  • Adults who experienced high maternal sensitivity during their childhood were found to be more secure than those who experienced less sensitive mothers. (wikipedia.org)
  • Some research suggests that adult mothers display more maternal sensitivity than adolescent mothers who may in turn have children with a lower IQ and reading level than children of adult mothers. (wikipedia.org)
  • This abstract is limited to the first 260 measured newborns (131 girls and 129 boys) and partial maternal data. (ahajournals.org)
  • Maternal age, obstetric complications, and the outcome of pregnancy. (nih.gov)
  • Data from 44,386 pregnancies were analyzed to determine if advancing maternal age influences frequency or outcome of antenatal disorders. (nih.gov)
  • 2011) Is young maternal age really a risk factor for adverse pregnancy outcome in a Canadian tertiary referral hospital? (scirp.org)
  • Carolan, M. and Frankowska, D. (2011) Advanced maternal age and adverse perinatal outcome: A review of the evidence. (scirp.org)
  • The research on the relationship between maternal age and birth outcome has left important gaps, however. (guttmacher.org)
  • Small for gestational age (SGA) was the only adverse pregnancy outcome with enough exposed cases to yield meaningful results. (cdc.gov)
  • Main outcome measure Risk of miscarriage according to the woman's age and pregnancy history estimated by logistic regression. (bmj.com)
  • OBJECTIVE To examine the impact of gestational diabetes mellitus(GDM) on perinatal outcome in a setting where influences of maternal age and obesity would be minimal. (diabetesjournals.org)
  • RESEARCH DESIGN AND METHODS A case-control study was done to compare the outcome of pregnancy in 65 women with GDM and 153 women with normal carbohydrate metabolism matched for age, height, and prepregnancy weight. (diabetesjournals.org)
  • This study focused on changes in demographic, social, and health-care patterns and pregnancy outcome related to maternal age from 1978-79 to 1994 in Ribeirão Preto, São Paulo State, Brazil. (scielo.br)
  • However, despite these demographic changes, there is little information on how changes in social variables like maternal education, marital status, and pregnancy outcome were involved in the process. (scielo.br)
  • ConclusionsThe risk of adverse pregnancy outcome increases with advancing maternal age. (medworm.com)
  • Women aged ≥40, have an increased risk of adverse perinatal and maternal outcome when pregnancy goes beyond 41 weeks. (medworm.com)
  • 1) Characterize the association between maternal age and the outcome of labor. (naturalremediescures.com)
  • Maternal age or seasonal timing of pregnancy did not affect the outcome in Ro/La-negative pregnancies. (diva-portal.org)
  • Trial of labor in patients with a previous cesarean section: does maternal age influence the outcome? (eurekamag.com)
  • The main outcome measure was obesity (BMI for age and sex ≥ 95th percentile) at 5 years of age. (eurekamag.com)
  • Cardiac (14%), obstetric (14%), and neonatal (15%) complications were noted, including one maternal death and five stillbirths. (gu.se)
  • Age above 35 years was of borderline importance for cardiac complications (p = 0.054) and was not a significant additional risk factor for obstetric or neonatal complications. (gu.se)
  • CONCLUSION: Maternal age should be combined with other maternal characteristics and obstetric history when calculating an individualised adjusted risk for adverse pregnancy complications. (biomedsearch.com)
  • Results Women of advanced age had slightly higher scores of psychological distress over the period than the reference group, also after controlling for obstetric and infant variables. (wiley.com)
  • Consequently, the study shows only the tip of the iceberg with respect to the true effect of maternal age on obstetric problems. (acpjc.org)
  • The perinatal mortality rate progressively increased from 25/1000 at age 17 ro 19 years to 69/1000 after age 39. (nih.gov)
  • Maternal perinatal depressive symptoms and offspring psychotic experiences at 18 years of age: a longitudinal study. (onmedica.com)
  • However, the association between maternal depression during the perinatal period and offspring psychotic experiences has not been investigated. (onmedica.com)
  • Goetzinger also suggested in her presentation that women of advanced maternal age may pay greater attention to healthy behaviors (prenatal vitamins, diet, exercise) and abstain from unhealthy behaviors compared with younger women. (medpagetoday.com)
  • We examined the association of prenatal depressive symptoms at mid-pregnancy with child cognition at age 3 years in Project Viva, a pre-birth cohort study of 1030 mother-child pairs in eastern Massachusetts. (rti.org)
  • We found no evidence to suggest that maternal prenatal depression is independently associated with early child cognition. (rti.org)
  • All women should be offered prenatal diagnosis, regardless of maternal age," says Dr. Dolan in keeping with recent ACOG recommendations. (fitpregnancy.com)
  • Estimated percentage of women with a live birth who for a period of two weeks or longer during pregnancy felt sad, empty or depressed for most of the day and lost interest in most things they usually enjoyed, by maternal age (e.g., among California women ages 15-19 with a live birth in 2013-2015, an estimated 18.3% experienced prenatal symptoms of depression). (kidsdata.org)
  • Data are available at the county level for prenatal and postpartum symptoms of depression overall, and at the state level by family income level, maternal age, prenatal health insurance coverage, and race/ethnicity. (kidsdata.org)
  • Maternal age at menarche was assessed from prenatal questionnaires administered to the women. (bmj.com)
  • In the current study we tested whether prenatal exposure to maternal obesity increases the offspring's vulnerability to stress-related psychiatric disorders. (ebscohost.com)
  • Results: Long-lasting, delayed impairments to anxiety-like behaviors and stress coping strategies resulted on account of prenatal exposure to maternal obesity. (ebscohost.com)
  • BackgroundPrenatal programming by maternal dietary protein deprivation and prenatal dexamethasone result in a reduction in nephron number and hypertension when the offspring are studied as adults.MethodsTo determine whether prenatal dietary protein deprivation results in a reduction in nephron. (ebscohost.com)
  • Mongolia - Cause of death, by communicable diseases and maternal, prenatal and nutrition conditions, ages 35-59, male (% relevant age) - actual values, historical data, forecasts and projections were sourced from the World Bank on August of 2020. (tradingeconomics.com)
  • Communicable diseases and maternal, prenatal and nutrition conditions include infectious and parasitic diseases, respiratory infections, and nutritional deficiencies such as underweight and stunting. (tradingeconomics.com)
  • This increase in the average maternal age as well as late pregnancies is boosting the global prenatal and newborn genetic testing market to adopt faster and more efficient technologies. (transparencymarketresearch.com)
  • Maternal PON1 genotype might modify the associations between prenatal OP exposure and children's neurodevelopment at 24 months of age. (springer.com)
  • Here we characterized the glucose-insulin axis in the first trimester of human pregnancy and assessed the effect of maternal obesity and fat mass.Methods: In this cross-sectional study, maternal blood samples (N = 323) were collected during voluntary pregnancy termination (gestational age 4+0-11+6 weeks) after overnight fasting. (medworm.com)
  • Methods: We used a mouse model of maternal diet-induced obesity to investigate whether maternal obesity affects the response to adult chronic stress exposure in young adult (3-month-old) and aged adult (12-month-old) offspring. (ebscohost.com)
  • Methods The association between maternal weight gain and child IQ was examined using serial antenatal weight measurements (median 12) from a prospective cohort of non-obese Scandinavian women (1986-1988). (bmj.com)
  • Celebrity news about very late pregnancies in late 40s may make you think that it's easy to get pregnant at that age, but people are not always aware that they likely had assistance with IVF or even used a previously frozen egg or donor egg," says Dr. Kirkham. (womenshealthmatters.ca)
  • Childbearing age continues to rise and, with the increasing implementation of assisted reproductive technology (ART), the number of multiple pregnancies has also risen. (ovid.com)
  • Their analysis showed a linear association between the risk of having a cesarean section and advancing maternal age in first pregnancies. (naturalremediescures.com)
  • This may be one of the reasons behind an increase in miscarriages, trisomic pregnancies and infertility with advanced maternal age. (elifesciences.org)
  • 634 272 women who were 12 to ≥ 45 years of age and had 1 221 546 pregnancies between 1978 and 1992. (acpjc.org)
  • A woman's risk of having a baby with chromosomal abnormalities increases with her age. (wikipedia.org)
  • The risk of the mother dying before the child becomes an adult increases by more advanced maternal age, such as can be demonstrated by the following data from France in 2007: The above table is not to be confused with maternal mortality. (wikipedia.org)
  • The risk of offspring overweight that is associated with 5 excess pounds of net pregnancy weight gain increases with maternal BMI. (nih.gov)
  • Many people assume women over 35 commonly get pregnant with twins thanks to IVF treatments, but the surprising truth is that your likelihood of naturally conceiving multiples increases with age. (thebump.com)
  • As your age increases, so do the general health risks to you and baby during pregnancy. (thebump.com)
  • As women age, the likelihood of having a multitude of medical conditions like hypertension and diabetes goes up, and that is why the risk of potential pregnancy complications increases. (fitpregnancy.com)
  • The modeling strategy evaluated effects of continuous increasing maternal and paternal age and 5-year age increases adjusted for the age of the other parent. (springer.com)
  • Objective To investigate if advanced maternal age at first birth increases the risk of psychological distress during pregnancy at 17 and 30 weeks of gestation and at 6 and 18 months after birth. (wiley.com)
  • As maternal age increases, risks of birth defects increase. (wikibooks.org)
  • As women age, their risk of having a child with a chromosomal difference increases. (wikibooks.org)
  • Aneuploidy in human eggs increases with advanced maternal age, which may explain why it is more difficult for women to get pregnant as they get older, and why miscarriages and Down syndrome are more likely in women of advanced age. (cam.ac.uk)
  • The results of this study showed that the number of infants with LBW increases with increasing mother's age. (magiran.com)
  • In between-family models, when compared with maternal ages 25-29, maternal ages 35-39 and 40 and above are associated with 1.1 percentage point (95% CI: 0.8,1.4) and 2.2 percentage point (95% CI: 1.4,2.9) increases, respectively, in the probability of LBW. (lse.ac.uk)
  • Together, our data reveal multiple age-related changes in chromosome architecture that could explain why oocyte aneuploidy increases with advanced maternal age. (elifesciences.org)
  • This occurs because age increases the chances that a woman's egg cells will have the wrong number of chromosomes. (elifesciences.org)
  • Maternal choline supplementation improves spatial mapping and increases basal forebrain cholinergic neuron number and size in aged Ts65Dn mice. (sigmaaldrich.com)
  • In addition, a significant interaction was found between maternal BMI and gestational weight gain (P = 0.03). (nih.gov)
  • Conclusion Women of 32 years and beyond had slightly increased risk of psychological distress during pregnancy and the first 18 months of motherhood compared with women aged 25-31 years. (wiley.com)
  • In conclusion, maternal smoking did not inhibit the production of anti-microbial IgA, suggesting that other factors are responsible for the increased susceptibility to infection in these infants. (biomedsearch.com)
  • CONCLUSION: This study identifies maternal age and seasonal timing of pregnancy as novel risk factors for heart block development in children of Ro/La-positive women. (diva-portal.org)
  • Conclusion: Our results suggest that the associations between maternal dietary patterns during pregnancy and body composition of the child at age 6 y are to a large extent explained by sociodemographic and lifestyle factors of mother and child. (eur.nl)
  • Reducing maternal BMI in the preconception period in overweight women and preventing excessive weight gain in pregnancy for all women appear to be appropriate strategies to address the childhood obesity epidemic. (nih.gov)
  • T he prevalence of overweight and obesity in Australian preschool-aged children has doubled in the past 10-15 years and is continuing to rise. (mja.com.au)
  • We found that the glucocorticoid receptor (GR, Nr3c1 ) is upregulated in various hypothalamic nuclei on account of maternal obesity. (ebscohost.com)
  • Conclusions: These findings indicate that maternal obesity parallels the deleterious effects of adult chronic stress exposure, and furthermore identifies GR/FKBP51 signaling as a novel candidate pathway regulated by maternal obesity. (ebscohost.com)
  • To identify maternal and early childhood risk factors for obesity and overweight among children at age 5 in the state of Alabama. (eurekamag.com)
  • In addition, the aging of the developing eggs in the ovary is associated with an increased risk for spontaneous miscarriage and the birth of infants with chromosomal abnormalities such as Down syndrome and Edwards syndrome . (encyclopedia.com)
  • When the infants were 24 months corrected age, mother-child interaction was videotaped during free play at home. (nih.gov)
  • Levels of exposure to PYRs was assessed by metabolite (3-phenoybenzoic acid, 3-PBA) concentration in maternal spot urine sampled in the first trimester of index pregnancy, and infant development was assessed at 18 months of age using the Kinder Infants Development Scale (KIDS), which is based on a questionnaire to the caretaker. (mdpi.com)
  • To find predictive and indicative markers of risk for development of retinopathy of prematurity (ROP) and its progression to the stage requiring laser treatment, in premature infants whose gestational age (GA) was under 33 weeks. (hindawi.com)
  • Small for gestational age (SGA) infants are at increased risk of type 2 diabetes in adulthood. (frontiersin.org)
  • 10th percentile) and 161 optimal birth weight (25th-75th percentiles) control infants in the 3D (design, develop and discover) birth cohort in Canada, we assessed whether maternal circulating placental growth factor (PlGF), a biomarker of placental function, is associated with metabolic health biomarkers in SGA infants. (frontiersin.org)
  • 25th percentile) and normal maternal PlGF concentrations, cord plasma IGF-I and leptin concentrations were lower than control infants, but the decreases were to a greater extent in SGA infants with low maternal PlGF. (frontiersin.org)
  • Cord blood leptin levels were lower comparing SGA infants with low vs. normal maternal PlGF levels ( P = 0.01). (frontiersin.org)
  • SGA infants with low maternal circulating PlGF levels at late gestation were characterized by greater decreases in cord blood IGF-I and leptin concentrations. (frontiersin.org)
  • Maternal circulating PlGF appears to be associated with neonatal metabolic health profile in SGA infants. (frontiersin.org)
  • To address this knowledge gap, we tested the hypothesis that maternal PlGF, a biomarker of placental function, may be associated with neonatal metabolic health profile in SGA infants, as indicated by cord blood concentrations of insulin, proinsulin, insulin-like growth factor-I (IGF-I), leptin, and high-molecular weight (HMW) adiponectin. (frontiersin.org)
  • Infants were assessed with the Bayley Scale of Infant Development, Second Edition (BSID-II) at 12, 26, and 52 weeks of age. (womensmentalhealth.org)
  • However, when comparing the BD+ and BD- groups, the BD+ infants at one year of age were less likely than BD- infants to score above the 75th percentile (11.5% vs. 40%) on the Motor Quality Index (a subset of the Bayley Scale). (womensmentalhealth.org)
  • Their infants (n = 72) were assessed at age 2½ years. (bmj.com)
  • Of course, problems don't suddenly set in the moment you turn a certain age-rather, the likelihood of complications grows incrementally as women get older, he explains. (thebump.com)
  • Pregnant women who had low socioeconomic status during childhood and who have poor family social support appear to prematurely age on a cellular level, potentially raising the risk for complications, a new study has found. (medicalxpress.com)
  • No significant differences between diabetic patients and control subjects were found with respect to paternal age, maternal parity, placental weight or any of the birth size parameters, or interventions and complications during delivery. (diabetesjournals.org)
  • Conclusions: Maternal occupational exposure to PAHs was found to be associated with increased risk of SGA offspring. (cdc.gov)
  • Conclusions Maternal smoking during pregnancy is associated with the cumulative incidence of asthma in offspring between 31 and 46 years. (ersjournals.com)
  • CONCLUSIONS: After full adjustment, the only significant predictors of the height-for-age z-score of the child at 3 years were the heights of both parents and maternal education. (muni.cz)
  • The relationship between maternal age and UTD coverage remained statistically significant after adjusting for a broad range of maternal, child and household factors. (nih.gov)
  • This study was conducted to determine the relationship between maternal age during pregnancy and maternal hematological parameters and anthropometric status in neonatal. (magiran.com)
  • Among participants who completed the 2-year questionnaire and had complete mental health data (n=1146), 305 women (27%) were classified as high maternal mental health risk. (bmj.com)
  • Other recent studies that analyzed the effects of young maternal age tended to compare teenagers to women in their 20s only, and either ignored older women or grouped them all together. (guttmacher.org)
  • We aimed to examine the associations of maternal B-vitamin status with gestational age, birth weight, and length in a birth cohort study in Singapore. (sigmaaldrich.com)
  • Disparities in breastfeeding practices have been shown for numerous factors including maternal age. (hindawi.com)
  • The risks and harms of pregnancy and childbirth are considered to increase after the age of 35. (eurekalert.org)
  • The age of over 35 as such was not a significant independent risk factor, but the risks increased when advanced maternal age was combined with an additional risk factor. (eurekalert.org)
  • Among blacks, however, 15-19-year-olds faced significantly lower risks of delivering low-birth-weight babies than did black women aged 25-29. (guttmacher.org)
  • I don't want to downplay the risks of genetic abnormalities and other maternal risks of pregnancy with advancing ages, but I would urge my peers to counsel their patients that the [odds] of having a normal child is higher [than previously thought]," she said. (medpagetoday.com)
  • Advanced Maternal Age (AMA) is the term for the general reality that the risks of having trouble conceiving a healthy pregnancy, as well as carrying a healthy pregnancy, are increased in 'older' women," says Joshua U. Klein, MD, FACOG, chief medical officer at Extend Fertility , a New York City-based egg freezing service. (thebump.com)
  • But because most risks start increasing meaningfully in the mid-30s, a common age cut-off for AMA is age 35. (thebump.com)
  • Here, we break down the possible risks women of advanced maternal age may face during each leg of the journey, and what you need to know to have the healthiest pregnancy possible. (thebump.com)
  • Advanced maternal age begins at 35 years of age because a woman's risk of having a child with a chromosomal difference at 35 is equal to the risk of having a miscarriage via an amniocentesis (both risks are equal to 1 in 200). (wikibooks.org)
  • With the birth rates for women between 35 and 39 years of age now higher than for those in their early 20s, Dr. Kirkham says it's important for anyone considering pregnancy to understand their fertility and risks they may face down the road. (womenshealthmatters.ca)
  • Risks related to fertility and pregnancy increase around age 35 and are higher for women over 40. (womenshealthmatters.ca)
  • Individualised risks of stillbirth at advanced maternal age: A literature review of the evidence. (thefreelibrary.com)
  • Jolly M, Sebire N, Harris J, Robinson S, Regan L (2000) The risks associated with pregnancy in women aged 35 years or older. (springer.com)
  • Dr. Mercado-Medina notes the risk for spontaneous abortion, ectopic pregnancy, preeclampsia, gestational diabetes, stillbirth, and chromosomal abnormalities like Down Syndrome all increase with age. (fitpregnancy.com)
  • Age-related risk for spontaneous abortion, ectopic pregnancy, and stillbirth. (acpjc.org)
  • A J-shaped relation existed between maternal age and stillbirth, but the association was not as strong as for spontaneous abortion and ectopic pregnancy. (acpjc.org)
  • The relation between stillbirth and maternal age, straightforward as it may seem, is much more difficult to comprehend. (acpjc.org)
  • Maternal cohort, time of stillbirth, and maternal age effects in Italian stillbirth mortality. (bmj.com)
  • Having identified these changes, we can now try to develop ways that allow us to prevent or correct for these age-related changes in chromosome architecture in order to decrease aneuploidy in eggs from older women and to increase their chances of having a family. (cam.ac.uk)
  • The mechanisms that lead to an increase in aneuploidy with advanced maternal age are largely unclear. (elifesciences.org)
  • The present study tested the hypothesis that maternal choline supplementation (MCS) improves spatial mapping and protects against BFCN degeneration in the Ts65Dn mouse model of DS and AD. (sigmaaldrich.com)
  • During these childbearing years, depression can negatively impact maternal behaviors that are crucial for infant growth and development. (hindawi.com)
  • This study examined the relationship between prepregnancy depression and breastfeeding duration by maternal age. (hindawi.com)
  • For women aged 20-24, 25-29, and 30-34 years with prepregnancy depression, the odds of never breastfeeding and breastfeeding 8 weeks or less were significantly higher than in women with no history of prepregnancy depression. (hindawi.com)
  • Notably, among women aged 25-29 with prepregnancy depression, the odds of never breastfeeding and breastfeeding 8 weeks or less were 93% (adjusted odds ratio (AOR) = 1.93, 95% CI =1.57-2.37) and 65% (AOR = 1.65, 95% CI = 1.37-1.99) higher compared to women with no history of prepregnancy depression, respectively. (hindawi.com)
  • 19 ) also reported larger amygdala but no change in hippocampal volumes in a sample of children exposed since birth to maternal depression, the latter a condition known to be associated with decreased parenting sensitivity and responsiveness ( 20 ). (pnas.org)
  • We measured maternal depressive symptoms using the Edinburgh Postnatal Depression Scale (EPDS), a self-report measure validated for use during pregnancy. (rti.org)
  • At 12 months of postnatal age, child competencies (development and behavior) were assessed, together with maternal adjustment (parenting stress and depression). (wiley.com)
  • With no history of depression, women of advanced age were not at higher risk. (wiley.com)
  • We aimed to investigate whether there is an association between maternal antenatal or postnatal depression and offspring psychotic experiences at 18 years of age.This longitudinal study used data from the Avon Longitudinal Study of Parents and Children (ALSPAC), a prospective birth cohort, which recruited 14 541 pregnant women with an estimated delivery date between April 1, 1991, and Dec 31, 1992. (onmedica.com)
  • For the main analysis, we used logistic regression to examine the associations between maternal depression (antenatal and postnatal) and offspring psychotic experiences at the age of 18 years. (onmedica.com)
  • If the association is found to be causal, it would strengthen the case for identifying and treating maternal depression during and after pregnancy.UK Medical Research Council and the Wellcome Trust. (onmedica.com)
  • The three most negative affecting factors are maternal depression, maternal stress, and maternal anxiety. (wikipedia.org)
  • RESULTS: The mean (SD) maternal glucose concentration and prepregnancy BMI were 103.8 (23.7) mg/dL and 24.3 (5.9) kg/m(2), respectively. (unc.edu)
  • However, maternal age, prepregnancy weight, and prepregnancy BMI were not correlated with birth weight. (diabetesjournals.org)
  • Maternal prepregnancy BMI, birth weight, and maternal smoking were associated with the child being overweight 1-12 cigarettes/day versus 0 cigarettes/day (RR: 1.40, 95% CI: 1.02-1.91). (eurekamag.com)
  • The corresponding paternal age effect is less pronounced. (wikipedia.org)
  • Autosomal dominant conditions are known to be associated with advanced paternal age, and it has been suggested that retinoblastoma (Rb) also exhibits a paternal age effect due to the paternal origin of most new germline RB1 mutations. (springer.com)
  • Mean maternal ages for survivors classified as having de novo germline mutations and sporadic Rb were similar (28.3 and 28.5, respectively) as were mean paternal ages (31.9 and 31.2, respectively), and all were significantly higher than the weighted general US population means. (springer.com)
  • In contrast, maternal and paternal ages for familial Rb did not differ significantly from the weighted US general population means. (springer.com)
  • Our study suggests a weak paternal age effect for Rb resulting from de novo germline mutations consistent with the paternal origin of most of these mutations. (springer.com)
  • This should put to rest discrepancies in previous studies showing that just maternal age or just paternal age are linked to having a child with autism," said Mohammad Hossein Rahbar, Ph.D., principal investigator and professor of epidemiology and biostatistics at The University of Texas School of Public Health, part of UTHealth. (healthcanal.com)
  • Our parental-specific haplotype score association analysis revealed that birth length and birth weight were significantly associated with the maternal transmitted haplotype score as well as the paternal transmitted haplotype score. (uib.no)
  • Dockerty JD, Draper G, Vincent T, Rowan SD, Bunch KJ (2001) Case-control study of parental age, parity and socioeconomic level in relation to childhood cancers. (springer.com)
  • The association between maternal age and risk for spontaneous abortion was not confounded by calendar year or maternal birth cohort, and it remained when stratified by parity status and number of previous spontaneous abortions. (acpjc.org)
  • Maternal type 1 diabetes does not seem to alter placental vascular impedance or induce placental inflammation. (medworm.com)
  • We consider an age-structured epidemiological model that accounts for both passively acquired maternal antibodies that decay and active immunity that wanes, permitting re-infection. (aimsciences.org)
  • Public Schooling for Young Children and Maternal Labor Supply ," American Economic Review , American Economic Association, vol. 92(1), pages 307-322, March. (repec.org)
  • After adjustment for maternal age, there was a significant association of occupational exposure with SGA (OR=2.2, 95% CI 1.3 to 3.8). (cdc.gov)
  • A positive association between the mother's haemoglobin and haematocrit during her 3rd trimester and her infant's haemoglobin and haematocrit was found at 9 months of age. (springer.com)
  • To further our understanding of the association of parental age and risk of de novo germline RB1 mutations, we evaluated the effect of parental age in a cohort of Rb survivors in the United States. (springer.com)
  • OBJECTIVE: The objective of the study was to determine the association between child BMI at age 3 years and maternal glucose concentration among women without pre-existing diabetes or a gestational diabetes mellitus (GDM) diagnosis. (unc.edu)
  • The possible association between maternal exposure to pyrethroid insecticides (PYRs) during pregnancy and infant development was explored. (mdpi.com)
  • A study was undertaken to examine the association between early onset menarche in pregnant women and asthma and atopic status of their children at 7 years of age. (bmj.com)
  • No consistent association was found between maternal age at menarche and asthma, eczema, hay fever or atopy in their children during early childhood. (bmj.com)
  • 10 However, a recent case control study in 129 asthmatic children did not find any association between maternal sex hormones in early pregnancy and the onset of allergic diseases in early childhood. (bmj.com)
  • We investigated the association of maternal age at delivery with adult offspring's lung function, respiratory symptoms and asthma, and potential differences according to offspring sex. (ersjournals.com)
  • Could the association reflect a biological effect of advanced age, or is it a consequence of physician and maternal preference? (naturalremediescures.com)
  • The association of maternal smoking during the last three months of pregnancy with onset of physician-diagnosed asthma and with lung function in adult offspring were studied by adjusted multivariate regression analyses. (ersjournals.com)
  • Significant association was detected between gestational smoke exposure and offspring's FEV1/FVC ratio at 31 years of age. (ersjournals.com)
  • The association was accentuated in offspring who reported at age 31 as having past respiratory problemsand/or, who had haplotype rs11702779-AA. (ersjournals.com)
  • It is unclear to what extent this association is confounded by maternal characteristics. (lse.ac.uk)
  • For leukemia, the regression model exhibited an independent association in maternal ages of 35-39 (adjusted HR 2.23, 95% CI 1.34-3.69, p = 0.002). (springer.com)
  • The specific nature of the association between maternal age and leukemia of the offspring necessitates further investigation. (springer.com)
  • Leukemia of the offspring may be associated with advanced maternal age although the specific nature of the association necessitates further investigation. (springer.com)
  • This prospective study examined the association between maternal intake of specific types of fatty acids, cholesterol, fish and meat during pregnancy and the risk of wheeze and eczema in the offspring. (unboundmedicine.com)
  • An association was seen between increasing maternal age and a higher risk for spontaneous abortion. (acpjc.org)
  • Because of its population-based design, it provides the best estimates to date of the incidence of pregnancy loss and its association with maternal age and previous reproductive history. (acpjc.org)
  • Accumulation of other risk factors with increasing age (i.e., those impairing tubal function) might also explain the association ( 2 ). (acpjc.org)
  • More research into the association of maternal diet in pregnancy and height of child is necessary. (muni.cz)
  • In contrast, the association between maternal height and gestational age is more likely to be causal. (uib.no)
  • Linear regression was used to assess the association between weight gain and children's (n=344) full-scale, performance and verbal IQ measured at age 5 using the Wechsler Preschool and Primary Scales of Intelligence-Revised. (bmj.com)
  • UTD coverage was significantly associated with maternal age: coverage increased as maternal age increased. (nih.gov)
  • After 26 years of age, coverage did not increase significantly as maternal age increased. (nih.gov)
  • Maternal smoking was associated with significantly higher total infant salivary IgA at 12 months of age (p = 0.026), and more chronic upper respiratory tract symptoms (p = 0.012). (biomedsearch.com)
  • Also, maternal age can significantly associate with some maternal hematological parameters and the anthropometric indices of infant. (magiran.com)
  • In observational analysis, maternal height was significantly associated with birth length (p = 6.31 × 10−9), birth weight (p = 2.19 × 10−15), and gestational age (p = 1.51 × 10−7). (uib.no)
  • In contrast, gestational age was significantly associated with the nontransmitted haplotype score (p = 0.0424) and demonstrated a significant (p = 0.0234) causal effect of every 1 cm increase in maternal height resulting in ~0.4 more gestational d. (uib.no)
  • Preterm behavior, maternal adjustment, and competencies in the newborn period: What influence do they have at 12 months postnatal age? (wiley.com)
  • This article examines whether preterm newborns' behavior and their mother's adjustment to the premature birth and infant hospitalization have an influence on subsequent infant development and behavior, maternal adjustment, and mother-infant relationship. (wiley.com)
  • Maternal folate status, but not that of vitamins B-12 or B-6, is associated with gestational age and preterm birth risk in a multiethnic Asian population. (sigmaaldrich.com)
  • In within-family models, the relationship between advanced maternal age and LBW or preterm is statistically and substantively negligible. (lse.ac.uk)
  • For instance, older maternal age at first childbirth is associated with higher educational attainment and income. (wikipedia.org)
  • Participants: Primiparous women with singleton births from 1992 through 2010 (N=798 674) were divided into seven age groups: less than17 years, 17-19 years and an additional five 5-year classes. (diva-portal.org)
  • Gaulden ME (1992) Maternal age effect: the enigma of Down syndrome and other trisomic conditions. (springer.com)
  • Birth weight and gestational age data were obtained from hospital records, and other anthropometric variables were measured within 72 h after birth. (sigmaaldrich.com)
  • Indeed, modeling this risk factor in mice through maternal immune activation (MIA) causes ASD- and SZ-like neuropathologies and behaviors in the offspring. (caltech.edu)
  • There are four important aspects of maternal sensitivity: dynamic process involving maternal abilities, reciprocal give-and-take with the infant, contingency on the infant's behavior, and quality of maternal behaviors. (wikipedia.org)
  • Associations between maternal age and preschool immunization coverage are unclear. (nih.gov)
  • 2014). Over 40% of women over the age of 40 are being induced (MOH, 2015b), although the reason for these inductions is unclear. (thefreelibrary.com)
  • However, the causes of this maternal age effect in humans have until recently been largely unclear. (cam.ac.uk)
  • However, it remains unclear why the risk of having cesarean section is associated with advancing maternal age. (naturalremediescures.com)
  • Yet the extent to which the maternal dietary environment contributes to adult disease vulnerability remains unclear. (ebscohost.com)
  • We built two sets of nested logistic regression models to detect an increased odds of the de novo germline mutation classification related to older parental age compared to sporadic and familial Rb classifications. (springer.com)
  • Regression analyses indicated that in the newborn period, maternal positive reappraisal and a planful coping style, more knowledge of child development, and previous experience with baby-sitting were associated with better infant development ( p =.002), maternal adjustment ( p =.012), and mother-child relationship ( p =.002) at 12 months. (wiley.com)
  • Logistic regression analyses based on generalised estimation equations were used to investigate associations between advanced maternal age and psychological distress. (wiley.com)
  • Multivariable linear regression models were used to examine associations of continuous BMI z scores with maternal glucose concentration. (unc.edu)
  • The relationship between KIDS score and maternal urinary 3-PBA levels was examined by a stepwise multiple regression analysis using biological attributes of the mother and infant, breast feeding, and nursing environment as covariates. (mdpi.com)
  • The analysis extracted 3-PBA and the nursing environment as significant to explain the KIDS score at 18 months of age with positive partial regression coefficients. (mdpi.com)
  • Multivariable linear regression models were used to estimate the relationship between the dietary patterns of parents (835 child-mother-father trios) during pregnancy and the length/height-for-age z-score of their offspring at birth, 3 years and 19 years. (muni.cz)
  • The trend of increased rates of cesarean sections with maternal age appears to be consistent in different countries and has previously been reported by several epidemiological studies. (naturalremediescures.com)
  • 2) Determine the proportion of the increase in primary cesarean rates that could be attributed to changes in maternal age distribution. (naturalremediescures.com)
  • This study adds to the evidence that advancing maternal age is associated with higher rates of cesarean sections. (naturalremediescures.com)
  • This study was undertaken to evaluate the effect of maternal age on the rate of vaginal delivery and the rate of uterine rupture in patients undergoing a trial of labor (TOL) after a prior cesarean delivery. (eurekamag.com)
  • Background and objective: The maternal glucose-insulin axis is central for metabolic adaptations required for a healthy pregnancy. (medworm.com)
  • Our objective was to evaluate whether advanced maternal age is independently associated with an increased risk of childhood cancers in the offspring. (springer.com)
  • Objective To identify the combination of factors most protective of developmental delay at age 2 among children exposed to poor maternal mental health. (bmj.com)
  • Objective: We aimed to examine whether maternal dietary patterns during pregnancy are associated with body composition of the child at age 6 y. (eur.nl)
  • Maternal support observed in early childhood was strongly predictive of hippocampal volume measured at school age. (pnas.org)
  • MIHA surveys postpartum women (15 years and older) who delivered a live birth about their own childhood hardships prior to age 14. (kidsdata.org)
  • For maternal reports of childhood injuries, single marital status is a risk factor for boys. (bmj.com)
  • The aim of this thesis was to investigate whether early colonization with certain gut microbiota species influences childhood immune responses and allergy development up to age five. (diva-portal.org)
  • Maternal intake of n-6 polyunsaturated fatty acids, especially linoleic acid, during pregnancy may increase the risk of childhood eczema. (unboundmedicine.com)
  • Comprehensive questionnaire and medical record data were collected spanning pregnancy, birth, early postpartum and early childhood providing a unique opportunity to consider multiple protective factors for child development in the context of poor maternal mental health. (bmj.com)
  • Data on maternal intake during pregnancy were assessed with a diet history questionnaire. (unboundmedicine.com)
  • The study showed that the above-mentioned four advanced maternal age groups clearly constitute a risk group that should be provided with enhanced guidance within maternity care. (eurekalert.org)
  • In a longitudinal study of depressed and healthy preschool children who underwent neuroimaging at school age, we investigated whether early maternal support predicted later hippocampal volumes. (pnas.org)
  • Of critical importance to the study of risk for psychopathology, animal models have elucidated the mechanisms by which maternal nurturance, a uniquely powerful form of early enrichment, promotes adaptive programming of the hypothalamic-pituitary-adrenal axis stress response and hippocampal development ( 2 , 3 ). (pnas.org)
  • Another study found that the child of a slightly undernourished mother is more likely to suffer early aging of the heart. (eurekalert.org)
  • This study aimed to determine if maternal age is associated with preschool immunization coverage and the importance of maternal age compared with other factors affecting vaccination coverage. (nih.gov)
  • I use an exogenous source of variation in maternal net earning opportunities, generated through school entrance age of children, to study intertemporal labor supply behavior. (repec.org)
  • According to a new study, advanced maternal age might not be as risky as some may believe. (placentabenefits.info)
  • The aim of this study was to evaluate the influence of maternal anemia on the infant's iron status at 9 months of age in Moncton, NB. (springer.com)
  • Objectives -This study examines gender and age differences in maternal reports of injuries in a cross sectional group of children aged 0-11 years. (bmj.com)
  • A Danish study shows that children were slightly more likely to be diagnosed with the condition before the age of three if their mother had the flu. (ageofautism.com)
  • Measurements and main results Questionnaire and clinical data of 5200 people, free of physician-diagnosed asthma by the age 31 years, of Northern Finland Birth Cohort 1966 Study was used. (ersjournals.com)
  • This study was designed to examine whether the dietary patterns of the parents during a pregnancy and of the respective child at 3 years are associated with the length/height-for-age z-score of child at birth, 3 years of age and at 19 years of age. (muni.cz)
  • Assessing the feasibility of conducting a prospective Reproductive Age Mortality Survey (RAMOS) study in the low-income setting of Mangochi District, Malawi to obtain cotemporaneous estimates of the number, cause of and conditions associated with maternal deaths (MD) in all women of reproductive age (WRA) ( n = 207 688). (biomedcentral.com)
  • At 35 years of age the risk of having a baby with chromosomal abnormalities is 1 in 204, at 37 years 1 in 130, at 39 1 in 81, and going as high as 1 in 39 at 42 years of maternal age," she says. (fitpregnancy.com)
  • In the U.S., the average age of first childbirth was 26.9 in 2018. (wikipedia.org)
  • In the USA, the average age at which women bore their first child advanced from 21.4 years old in 1970 to 26.9 in 2018. (wikipedia.org)
  • California Department of Public Health, Maternal, Child and Adolescent Health (MCAH) Program, & University of California, San Francisco, Center on Social Disparities in Health, Maternal and Infant Health Assessment (MIHA) Survey (Mar. 2018). (kidsdata.org)
  • The positive effect of maternal support on hippocampal volumes was greater in nondepressed children. (pnas.org)
  • The result suggested a positive effect of maternal PYR exposure on infant development, the reason for which is not clear, but an unknown confounding factor is suspected. (mdpi.com)
  • The average maternal age has increased steadily for the past many years - and that is actually not so bad. (medicalxpress.com)
  • In logistic and linear multilevel mixed models we adjusted for participants' characteristics (age, education, centre, number of older siblings) and maternal characteristics (smoking in pregnancy, education) while investigating for differential effects by sex. (ersjournals.com)
  • Maternal Antibodies and Autism and Flu Shots Oh Why? (ageofautism.com)
  • The research on maternal antibodies as a cause of some cases of autism continues to grow. (ageofautism.com)
  • That is interesting and similar to what I found in my reading, which brings me to the second method identified as a causative factor in producing these maternal antibodies -- toxic chemicals. (ageofautism.com)
  • Recurrence rates of only 10-20% despite persisting maternal antibodies indicate that additional factors are critical for the establishment of heart block. (diva-portal.org)
  • 8 In addition, women aged 35 and older, like teenagers, have higher rates of unintended pregnancy than do women in their 20s and early 30s. (guttmacher.org)
  • That's right: age is, well, just a number when it comes to understanding a woman's risk factors during pregnancy . (fitpregnancy.com)
  • Overall, we found that advanced maternal age was associated with a 40 percent decreased risk of having a child with one or more major congenital malformations, after controlling for other risk factors. (placentabenefits.info)
  • In previous studies, Rahbar said that because of the statistical models used, it was hard to assess both maternal and fraternal age as joint risk factors, a problem called multicollinearity. (healthcanal.com)
  • In a number of European countries (Spain), the mean age of women at first childbirth has crossed the 30 year threshold. (wikipedia.org)
  • The average age at first childbirth has seen a steady increase since the 1960s, and according to Statistics Canada's latest data, it is now just over 29 years old. (womenshealthmatters.ca)
  • Maternal occupational exposure to polycyclic aromatic hydrocarbons and small for gestational age offspring. (cdc.gov)
  • exposure to maternal bipolar disorder was not a predictor of deficits in these domains. (womensmentalhealth.org)
  • Also a reduction in FEV1/FVC ratio was observed at age 31 years in offspring with gestational smoke exposure. (ersjournals.com)
  • No significant exposure-response relationships were observed between maternal consumption of total fat, saturated fatty acids, monounsaturated fatty acids, eicosapentaenoic acid, arachidonic acid, cholesterol, meat and fish and the ratio of n-3 to n-6 polyunsaturated fatty acid consumption during pregnancy and infantile wheeze or eczema. (unboundmedicine.com)
  • Out of 424 deaths of WRA, 151 were MD giving a Maternal Mortality Ratio (MMR) of 363 per 100,000 live births (95 % CI: 307-425). (biomedcentral.com)
  • Reducing maternal mortality (MM) is therefore one of the priority goals on the international agenda - the target for Millenium Development Goal (MDG) 5a was to reduce the Maternal Mortality Ratio (MMR) by three quarters between 1990 and 2015 and recently this target has been reset to a global target of less than 70 maternal deaths per 100,000 live births by 2030 [ 2 , 3 ]. (biomedcentral.com)
  • The new global strategy for Ending Preventable Maternal Mortality (EPMM) calls for a new approach where all maternal deaths are counted [ 3 ]. (biomedcentral.com)
  • A Reproductive Age Mortality Survey (RAMOS) where all deaths among women of reproductive age (WRA) are investigated is considered the best approach in the absence of vital registration data [ 8 ]. (biomedcentral.com)