Midpalatal suture of osteopetrotic (op/op) mice exhibits immature fusion. (1/522)

The midpalatal suture was observed histologically in both toothless osteopetrotic (op/op) and normal (control) mice. The normal mice had a mature sutural structure, which consists of a well-developed cartilage cell zone and palatal bone. In contrast, the thickness of the cartilage cell zone was substantially greater in the op/op mice than that in the controls. Moreover, the cartilage cells in the op/op mice were frequently found in the palatal bone as well as in the sutural space, exhibiting an imperfect fusion. It seems that immature fusion at the sutural interface in the op/op mice is related to a decrease in biting or masticatory force accompanied by the failure of tooth eruption in addition to an essential defect in osteoclast differentiation, which is a congenital symptom in op/op mice.  (+info)

Motivation for and satisfaction with orthodontic-surgical treatment: a retrospective study of 28 patients. (2/522)

Motivation for starting treatment and satisfaction with treatment results were evaluated on the basis of replies to a 14-item questionnaire and clinical examination of 28 orthognathic patients from 6 months to 2 years after treatment. The most common reasons for seeking professional help were problems in biting and chewing (68 per cent). Another major reason was dissatisfaction with facial appearance (36 per cent). Many patients also complained of temporomandibular joint symptoms (32 per cent) and headache (32 per cent). Women (8/19) were more often dissatisfied with their facial appearance than men (2/9), but the difference was not statistically significant. In agreement with earlier studies, the results of orthognathic treatment fulfilled the expectations of almost every patient. Nearly 100 per cent of the patients (27/28) were satisfied with treatment results, although 40 per cent experienced some degree of numbness in the lips and/or jaw 1 year post-operatively. The most satisfied patients were those who stated temporomandibular disorders as the main reason for seeking treatment and whose PAR-index had improved greatly. The majority of the patients experienced the orthodontic treatment as painful and as the most unpleasant part of the whole treatment, but all the patients were satisfied with the pre-treatment information they were given on orthodontics. Orthodontic-surgical therapy should be of a high professional standard technically, but the psychological aspects are equally important in the treatment protocol. The professionals should make efforts to understand the patient's motivations for and expectations of treatment. Patients should be well prepared for surgery and supported for a long time after to help them to adjust to post-surgical changes.  (+info)

Mastication steal: an unusual precipitant of cerebrovascular insufficiency. (3/522)

An 83-year-old man had episodic dizziness, visual disturbance, and facial and extremity weakness associated with eating. Occlusion of the ipsilateral common carotid artery and stenosis or occlusion of the major collateral sources were demonstrated. We believe this anatomic configuration, combined with increases in demand for external carotid artery blood flow necessitated by the act of chewing, resulted in a vascular steal syndrome. An extended carotid endarterectomy was performed, and there were no additional episodes.  (+info)

Motor pattern specification by dual descending pathways to a lobster rhythm-generating network. (4/522)

In the European lobster Homarus gammarus, rhythmic masticatory movements of the three foregut gastric mill teeth are generated by antagonistic sets of striated muscles that are driven by a neural network in the stomatogastric ganglion. In vitro, this circuit can spontaneously generate a single (type I) motor program, unlike in vivo in which gastric mill patterns with different phase relationships are found. By using paired intrasomatic recordings, all elements of the gastric mill network, which consists mainly of motoneurons, have been identified and their synaptic relationships established. The gastric mill circuit of Homarus is similar to that of other decapod crustaceans, although some differences in neuron number and synaptic connectivity were found. Moreover, specific members of the lobster network receive input from two identified interneurons, one excitatory and one inhibitory, that project from each rostral commissural ganglion. Integration of input from these projection elements is mediated by synaptic interactions within the gastric mill network itself. In arrhythmic preparations, direct phasic stimulation of the previously identified commissural gastric (CG) interneuron evokes gastric mill output similar to the type I pattern spontaneously expressed in vitro and in vivo. The newly identified gastric inhibitor interneuron makes inhibitory synapses onto a different subset of gastric mill neurons and, when activated with the CG neuron, drives gastric mill output similar to the type II pattern that is only observed in the intact animal. Thus, two distinct phenotypes of gastric mill network activity can be specified by the concerted actions of parallel input pathways and synaptic connectivity within a target central pattern generator.  (+info)

Variation in ruminants' preference for tall fescue hays cut either at sundown or at sunup. (5/522)

Plants vary diurnally in concentrations of nonstructural carbohydrates. If ruminants prefer forages with higher total nonstructural carbohydrates (TNC), then the preference for hays harvested within the same 24-h period may vary. An established field of tall fescue (Festuca arundinacea Schreb.) was harvested six times in the vegetative stage. Harvests were paired such that each cutting at sundown (PM) was followed by a cutting the next morning at sunup (AM). We harvested in this manner three times, resulting in six hays. The hays were field-dried, baled, and passed through a hydraulic bale processor prior to feeding. Experiments were conducted with sheep, goats, and cattle, using six animals in each case. During an adaptation phase, hays were offered alone as meals. In the experimental phase, every possible pair of hays (15 pairs) was presented for a meal. Data were analyzed by multidimensional scaling and by traditional analyses. Multidimensional scaling indicated that selection was based on a single criterion. Preference for PM hays was greater than for AM hays (P < .01) in all experiments. Increased preference was associated with increased TNC (P < .01) and in vitro true DM disappearance (P < .01) and decreased fiber concentration (P < .01; NDF, ADF, cellulose, and ADL). Mowing hay late in the day was effective in increasing forage preference.  (+info)

Feeding problems in merosin deficient congenital muscular dystrophy. (6/522)

Feeding difficulties were assessed in 14 children (age range 2-14 years) with merosin deficient congenital muscular dystrophy, a disease characterised by severe muscle weakness and inability to achieve independent ambulation. Twelve of the 14 children were below the 3rd centile for weight. On questioning, all parents thought their child had difficulty chewing, 12 families modified the diet, and 13 children took at least 30 minutes to complete a meal. On examination the mouth architecture was abnormal in 13 children. On videofluoroscopy only the youngest child (2 years old), had a normal study. The others all had an abnormal oral phase (breakdown and manipulation of food and transfer to oropharynx). Nine had an abnormal pharyngeal phase, with a delayed swallow reflex. Three of these also showed pooling of food in the larynx and three showed frank aspiration. These six cases all had a history of recurrent chest infections. Six of eight children who had pH monitoring also had gastro-oesophageal reflux. As a result of the study five children had a gastrostomy, which stopped the chest infections and improved weight gain. This study shows that children with merosin deficient congenital muscular dystrophy have difficulties at all stages of feeding that progress with age. Appropriate intervention can improve weight gain and reduce chest infections. The severity of the problem has not been previously appreciated in this disease, and the study shows the importance of considering the nutritional status in any child with a primary muscle disorder.  (+info)

Cheek and tongue pressures in the molar areas and the atmospheric pressure in the palatal vault in young adults. (7/522)

The pressures acting on the maxillary and mandibular posterior teeth from the tongue and cheeks were measured in 24 adults aged 22-29 years. In addition, the pressure in the palatal vault was recorded. The pressure at two maxillary (buccal and lingual) and two mandibular (buccal and lingual) measuring points, and in the palatal vault was recorded simultaneously. Repeated recordings of the pressures at rest, and during chewing and swallowing were made. The pressures at rest were of similar magnitude (about 2 g/cm2) at the buccal and lingual sides of the mandibular posterior teeth. The median resting pressure at the maxillary posterior teeth was 2.7 g/cm2 on the buccal side and 1.0 g/cm2 on the lingual side. The difference in the maxilla was significant, but not in the mandible. It was concluded that the equilibrium of tooth position is maintained by the pressure from the cheeks and the tongue. During chewing and swallowing the pressures on the lingual side of the teeth were greater than those on the buccal side. At rest about half of the subjects had a negative pressure at the palatal vault, but no correlations between the resting pressure at the palatal vault and the resting pressures on the teeth were found.  (+info)

Features of cortically evoked swallowing in the awake primate (Macaca fascicularis). (8/522)

Although the cerebral cortex has been implicated in the control of swallowing, the output organization of the cortical swallowing representation, and features of cortically evoked swallowing, remain unclear. The present study defined the output features of the primate "cortical swallowing representation" with intracortical microstimulation (ICMS) applied within the lateral sensorimotor cortex. In four hemispheres of two awake monkeys, microelectrode penetrations were made at 5 mm deep to the cortical surface corresponding to both the white matter underlying the CMA and the frontal operculum; EMG patterns of swallows elicited from these four cortical regions showed some statistically significant differences. Whereas swallowing ONLY was evoked at some sites, particularly within the deep cortical area, swallowing was more frequently evoked together with other orofacial responses including rhythmic jaw movements. Increasing ICMS intensity increased the magnitude, and decreased the latency, of the swallow-related EMG burst in the genioglossus muscle at some sites. These findings suggest that a number of distinct cortical foci may participate in the initiation and modulation of the swallowing synergy as well as in integrating the swallow within the masticatory sequence.  (+info)

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