Tandem Mass Spectrometry
Spectrometry, Mass, Electrospray Ionization
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Gas Chromatography-Mass Spectrometry
Chromatography, High Pressure Liquid
Spectrometry, Mass, Secondary Ion
Molecular Sequence Data
Amino Acid Sequence
Spectrometry, Mass, Fast Atom Bombardment
Electrophoresis, Gel, Two-Dimensional
Deuterium Exchange Measurement
Reproducibility of Results
Magnetic Resonance Spectroscopy
Solid Phase Extraction
Sensitivity and Specificity
Limit of Detection
Body Mass Index
Substance Abuse Detection
Chromatography, Thin Layer
Indicators and Reagents
Protein Processing, Post-Translational
Analytic Sample Preparation Methods
Electrophoresis, Polyacrylamide Gel
Sequence Analysis, Protein
Indicator Dilution Techniques
Protein Array Analysis
Spectroscopy, Fourier Transform Infrared
Sequence Homology, Amino Acid
Chromatography, Ion Exchange
Chemistry Techniques, Analytical
Protein Structure, Tertiary
Volatile Organic Compounds
Solid Phase Microextraction
Metabolism, Inborn Errors
Principal Component Analysis
Doping in Sports
Radioisotope Dilution Technique
Two-Dimensional Difference Gel Electrophoresis
Metabolic Networks and Pathways
Tumor Markers, Biological
Less common "doping" agents and substances encountered during routine screening for drugs. (1/17751)The chromatographic and spectroscopic properties of several unusual substances which have been detected in the "alkaloidal" chloroform extract from racehorse urine and saliva samples are reported. Some of these substances have been identified by combined gas chromatography-mass spectrometry and the source of the substance is stated where this is known. Other substances whose identity is not known have been detected and their mass spectra show characteristic amine fragments. The occurrence of these unidentified substances is more frequent in aged urine samples and it would therefore appear that they are associated with putrefaction. (+info)
Urinary lithium: distribution shape, reference values, and evaluation of exposure by inductively coupled plasma argon-emission spectrometry. (2/17751)Inductively coupled plasma argon-emission spectrometry (ICPAES) was used to evaluate the lithium content of undiluted urine samples. The method can be performed with 1 mL of urine in a single tube using a routine ICPAES analysis for rapid and convenient assessment of lithium exposure in humans. Urine samples obtained from male workers (n = 86) who had not been exposed to lithium were used for the determination of this element by ICPAES. The obtained concentrations were corrected using a specific gravity of 1.024. The particular frequency distribution resulted in a log-normal distribution diagram for anatomical spread. Geometric mean value for urinary lithium in the nonexposed male workers was 23.5 microg/L, and the confidence interval from a log-normal distribution was 11.0 to 50.5 microg/L. Taking into consideration a short biological half-life and the massive urine excretion of lithium, urinary lithium was considered to be a useful index for monitoring of exposure. Calibration curves obtained for lithium standards had good sensitivity and linearity. Good reproducibility was assessed by lithium addition to urine samples. It was concluded that the obtained lithium reference values would be useful for the early diagnosis of lithium intoxication or in the assessment of the degree of exposure to lithium in subjects at risk. (+info)
Archive of mass spectral data files on recordable CD-ROMs and creation and maintenance of a searchable computerized database. (3/17751)A database containing names of mass spectral data files generated in a forensic toxicology laboratory and two Microsoft Visual Basic programs to maintain and search this database is described. The data files (approximately 0.5 KB/each) were collected from six mass spectrometers during routine casework. Data files were archived on 650 MB (74 min) recordable CD-ROMs. Each recordable CD-ROM was given a unique name, and its list of data file names was placed into the database. The present manuscript describes the use of search and maintenance programs for searching and routine upkeep of the database and creation of CD-ROMs for archiving of data files. (+info)
UV irradiation of polycyclic aromatic hydrocarbons in ices: production of alcohols, quinones, and ethers. (4/17751)Polycyclic aromatic hydrocarbons (PAHs) in water ice were exposed to ultraviolet (UV) radiation under astrophysical conditions, and the products were analyzed by infrared spectroscopy and mass spectrometry. Peripheral carbon atoms were oxidized, producing aromatic alcohols, ketones, and ethers, and reduced, producing partially hydrogenated aromatic hydrocarbons, molecules that account for the interstellar 3.4-micrometer emission feature. These classes of compounds are all present in carbonaceous meteorites. Hydrogen and deuterium atoms exchange readily between the PAHs and the ice, which may explain the deuterium enrichments found in certain meteoritic molecules. This work has important implications for extraterrestrial organics in biogenesis. (+info)
Relationship between UDP-glucose 4-epimerase activity and oligoglucose glycoforms in two strains of Neisseria meningitidis. (5/17751)Sodium dodecyl sulfate-polyacrylamide gel analysis of lipooligosaccharide (LOS) from Neisseria meningitidis has demonstrated considerable microheterogeneity in the variable region of LOS due to the presence of novel glycoforms. As a step toward understanding the basis for the expression of these novel glycoforms, we have examined the LOS structures and UDP-glucose 4-epimerase (epimerase) activity levels in two strains (NMB and MA-1) and their respective galE mutants. Strain NMB was found to have low epimerase activity and to contain multiple glycoforms, some of which appear to contain only glucose sugars. The galE mutant had only the oligoglucose glycoforms. Strain MA-1 had higher epimerase activity at both log and stationary phases (2- and 12.5-fold, respectively) and one glycoform with a putative lactosyl structure. Strain MA-1 galE had two glycoforms that contained one or two glucose residues. To understand the molecular basis for the different epimerase activities, we examined the predicted amino acid sequences of the respective galE open reading frames and determined the relative amounts of GalE protein. We found no significant differences between the predicted amino acid sequence of the GalE protein in NMB and that in MA-1. We observed no significant differences in the level of GalE protein between MA-1 and NMB at exponential or stationary phase. We also observed an 8.2-fold drop in epimerase activity in NMB between the log and stationary phases that was not due to the GalE protein level or low glucose levels. (+info)
Insulin-like growth factors I and II are unable to form and maintain their native disulfides under in vivo redox conditions. (6/17751)Insulin-like growth factor (IGF) I does not quantitatively form its three native disulfide bonds in the presence of 10 mM reduced and 1 mM oxidized glutathione in vitro [Hober, S. et al. (1992) Biochemistry 31, 1749-1756]. In this paper, we show (i) that both IGF-I and IGF-II are unable to form and maintain their native disulfide bonds at redox conditions that are similar to the situation in the secretory vesicles in vivo and (ii) that the presence of protein disulfide isomerase does not overcome this problem. The results indicate that the previously described thermodynamic disulfide exchange folding problem of IGF-I in vitro is also present in vivo. Speculatively, we suggest that the thermodynamic disulfide exchange properties of IGF-I and II are biologically significant for inactivation of the unbound growth factors by disulfide exchange reactions to generate variants destined for rapid clearance. (+info)
Purification and identification of a novel subunit of protein serine/threonine phosphatase 4. (7/17751)The catalytic subunit of protein serine/threonine phosphatase 4 (PP4C) has greater than 65% amino acid identity to the catalytic subunit of protein phosphatase 2A (PP2AC). Despite this high homology, PP4 does not appear to associate with known PP2A regulatory subunits. As a first step toward characterization of PP4 holoenzymes and identification of putative PP4 regulatory subunits, PP4 was purified from bovine testis soluble extracts. PP4 existed in two complexes of approximately 270-300 and 400-450 kDa as determined by gel filtration chromatography. The smaller PP4 complex was purified by sequential phenyl-Sepharose, Source 15Q, DEAE2, and Superdex 200 gel filtration chromatographies. The final product contained two major proteins: the PP4 catalytic subunit plus a protein that migrated as a doublet of 120-125 kDa on SDS-polyacrylamide gel electrophoresis. The associated protein, termed PP4R1, and PP4C also bound to microcystin-Sepharose. Mass spectrometry analysis of the purified complex revealed two major peaks, at 35 (PP4C) and 105 kDa (PP4R1). Amino acid sequence information of several peptides derived from the 105 kDa protein was utilized to isolate a human cDNA clone. Analysis of the predicted amino acid sequence revealed 13 nonidentical repeats similar to repeats found in the A subunit of PP2A (PP2AA). The PP4R1 cDNA clone engineered with an N-terminal Myc tag was expressed in COS M6 cells and PP4C co-immunoprecipitated with Myc-tagged PP4R1. These data indicate that one form of PP4 is similar to the core complex of PP2A in that it consists of a catalytic subunit and a "PP2AA-like" structural subunit. (+info)
Identification of 17-methyl-18-norandrosta-5,13(17-dien-3beta-ol, the C19 fragment formed by adrenal side chain cleavage of a 20-aryl analog of (20S)-20-hydroxycholesterol. (8/17751)Incubation of (20R)-20-phenyl-5-pregnene-3beta,20-diol, an aromatic analog of (23S)-20-hydroxycholesterol, with an adrenal mitochondrial preparation leads to the formation of four compounds: pregnenolone, phenol, a C8 ketone, acetophenone, and a nonpolar C19 compound. This latter compound has now been identified by reverse isotope dilution analysis and by gas chromatography/mass spectrometry as 17-methyl-18-norandrosta-5,13(17)-dien-3beta-ol. From these results it is evident that enzymatic fission of the C-17,20 bond of this synthetic derivative occurs. On the other hand, when (20S)-20-hydroxy[21-14C]cholesterol was used as substrate, the analogous cleavage did not take place. Thus, substitution of an aromatic group on C-20 facilitates side chain cleavage between that carbon atom and the nucleus whereas neither of the naturally occuring precursors, cholesterol or its 20-hydroxylated counterpart, are metabolized to a C8 fragment. (+info)
Examples of inborn errors of metabolism include:
1. Phenylketonuria (PKU): A disorder that affects the body's ability to break down the amino acid phenylalanine, leading to a buildup of this substance in the blood and brain.
2. Hypothyroidism: A condition in which the thyroid gland does not produce enough thyroid hormones, leading to developmental delays, intellectual disability, and other health problems.
3. Maple syrup urine disease (MSUD): A disorder that affects the body's ability to break down certain amino acids, leading to a buildup of these substances in the blood and urine.
4. Glycogen storage diseases: A group of disorders that affect the body's ability to store and use glycogen, a form of carbohydrate energy.
5. Mucopolysaccharidoses (MPS): A group of disorders that affect the body's ability to produce and break down certain sugars, leading to a buildup of these substances in the body.
6. Citrullinemia: A disorder that affects the body's ability to break down the amino acid citrulline, leading to a buildup of this substance in the blood and urine.
7. Homocystinuria: A disorder that affects the body's ability to break down certain amino acids, leading to a buildup of these substances in the blood and urine.
8. Tyrosinemia: A disorder that affects the body's ability to break down the amino acid tyrosine, leading to a buildup of this substance in the blood and liver.
Inborn errors of metabolism can be diagnosed through a combination of physical examination, medical history, and laboratory tests such as blood and urine tests. Treatment for these disorders varies depending on the specific condition and may include dietary changes, medication, and other therapies. Early detection and treatment can help manage symptoms and prevent complications.
There are several different types of obesity, including:
1. Central obesity: This type of obesity is characterized by excess fat around the waistline, which can increase the risk of health problems such as type 2 diabetes and cardiovascular disease.
2. Peripheral obesity: This type of obesity is characterized by excess fat in the hips, thighs, and arms.
3. Visceral obesity: This type of obesity is characterized by excess fat around the internal organs in the abdominal cavity.
4. Mixed obesity: This type of obesity is characterized by both central and peripheral obesity.
Obesity can be caused by a variety of factors, including genetics, lack of physical activity, poor diet, sleep deprivation, and certain medications. Treatment for obesity typically involves a combination of lifestyle changes, such as increased physical activity and a healthy diet, and in some cases, medication or surgery may be necessary to achieve weight loss.
Preventing obesity is important for overall health and well-being, and can be achieved through a variety of strategies, including:
1. Eating a healthy, balanced diet that is low in added sugars, saturated fats, and refined carbohydrates.
2. Engaging in regular physical activity, such as walking, jogging, or swimming.
3. Getting enough sleep each night.
4. Managing stress levels through relaxation techniques, such as meditation or deep breathing.
5. Avoiding excessive alcohol consumption and quitting smoking.
6. Monitoring weight and body mass index (BMI) on a regular basis to identify any changes or potential health risks.
7. Seeking professional help from a healthcare provider or registered dietitian for personalized guidance on weight management and healthy lifestyle choices.
Resolution (mass spectrometry)
Protein mass spectrometry
Accelerator mass spectrometry
Aerosol mass spectrometry
Targeted mass spectrometry
Tandem mass spectrometry
Matrix (mass spectrometry)
Mass spectrometry imaging
Mass (mass spectrometry)
Mass Spectrometry Reviews
Fragmentation (mass spectrometry)
Capillary electrophoresis-mass spectrometry
British Mass Spectrometry Society
Mass spectrometry at Swansea
Gas chromatography-mass spectrometry
Time-resolved mass spectrometry
Membrane-introduction mass spectrometry
Liquid chromatography-mass spectrometry
Ion-attachment mass spectrometry
International Mass Spectrometry Foundation
Thermal ionization mass spectrometry
Flowing-afterglow mass spectrometry
History of mass spectrometry
Mass spectrometry data format
Journal of Mass Spectrometry
Isotope-ratio mass spectrometry
Secondary ion mass spectrometry
Intensity fading MALDI mass spectrometry
Canadian Society for Mass Spectrometry
Pacific Northwest National Laboratory
Lewis Joel Greene
40S ribosomal protein S30
Amount of substance
Proteomics Standards Initiative
Restriction of Hazardous Substances Directive
Systemic primary carnitine deficiency
Inductively coupled plasma mass spectrometry - Wikipedia
Chemical and Isotopics Mass Spectrometry -- Instrumentation | ORNL
Mass Spectrometry | Broad Institute
Spying on Cancer Cells with Mass Spectrometry | MIT Technology Review
Introduction to Mass Spectrometry and Imaging Mass Spectrometry
Using Tandem Mass Spectrometry for Metabolic Disease Screening Among Newborns
Centre for Biological Applications of Mass Spectrometry (CBAMS) - Concordia University
Thermal desorption - gas chromatography - mass spectrometry (TD-GC-MS)
RAPID COMMUNICATIONS IN MASS SPECTROMETRY. Journal. Print
SELECTBIO - Clinical Applications of Mass Spectrometry Agenda
American Society for Mass Spectrometry Archives - Dark Daily
Research methods/Spectroscopy/Mass spectrometry | American Association for the Advancement of Science (AAAS)
Mastering the art of Mass Spectrometry
Spatial distribution of the Shannon entropy for mass spectrometry imaging | PLOS ONE
MALDI-TOF Mass Spectrometry in the Clinical Lab | Beckman Coulter
A Resonance Ionization Spectroscopy/Resonance Ionization Mass Spectrometry Data Service. IV - Data Sheets for Be, In, Li, K, Rb...
Is mass spectrometry analysis performed on oligos before shipped? | IDT
Analysis of Fiber Dyes By Liquid Chromatography Mass Spectrometry (LC-MS) with Electrospray Ionization: Discriminating Between...
Using native mass spectrometry for drug development
PRIME PubMed | Authentication of animal fats using direct analysis in real time (DART) ionization-mass spectrometry and...
Cellenion Announces Co-Marketing Agreement for Single Cell Mass Spectrometry-Based Proteomics Analysis - BICO Group
Uncatalyzed reactions of 4,4′-diphenylmethane-diisocyanate with polymer polyols as revealed by matrix-assisted laser desorption...
Analysis of Amphetamine and Methamphetamine in Whole Blood by Solid Phase Extraction and Gas Chromatography - Mass Spectrometry...
The application of capillary electrophoresis and mass spectrometry to clinical and environmental problems - Open Research...
6-Pyruvoyltetrahydropterin synthase deficiency diagnosed in tandem mass spectrometry-based newborn screening
Optimisation of a gas chromatography-mass spectrometry method for the simultaneous determination of tetrahydrocannabinol and...
British Library EThOS: Study of the molecular details of p53 redox-regulation using Fourier transform ion cyclotron resonance...
Figure - Identification of Residual Blood Proteins in Ticks by Mass Spectrometry Proteomics - Volume 14, Number 8-August 2008 -...
Mass spectrometry scores for selected of the proteins purified by affinity chromatography using region A.
Cross-linking/Mass Spectrometry Combined with Ion Mobility on a timsTOF Pro Instrument for Structural Proteomics | bioRxiv
- Experts list the top challenges facing widespread adoption of proteomics in the medical laboratory industry Year-by-year, clinical laboratories find new ways to use mass spectrometry to analyze clinical specimens, producing results that may be more precise than test results produced by other methodologies. (darkdaily.com)
- The goal of the partnership is to combine Cellenion's cellenONE® and proteoCHIP TM with Thermo Fisher's TMT multiplexing technologies and Thermo Scientific™ Orbitrap™ mass spectrometers to deliver complete solutions, from single cell isolation and automated sample preparation through to mass spectrometry (MS)-based proteomics analysis on single cells. (cision.com)
- With single cell proteomics providing vital information on the state of individual cells within heterogeneous environments, the combination of this sample preparation technology with Thermo Fisher's TMT multiplexing technologies and Orbitrap mass spectrometers will provide researchers with powerful tools to standardize MS-based single cell proteomics workflows. (cision.com)
- De novo peptide sequencing via tandem mass spectrometry. (broadinstitute.org)
- Tandem mass spectra of 2 peptides from sheep hemoglobin β-subunit identified in a nymph of an Amblyomma americanum tick. (cdc.gov)
- Steady-state plasma concentrations of methadone, oxycodone, hydrocodone and tramadol were determined by HPLC tandem mass spectrometry. (medscape.com)
- Dr, Victor R. De Jesús setting up a liquid chromatography/tandem mass spectrometry run in the laboratory. (cdc.gov)
- Newborn screening for isovaleric acidemia using tandem mass spectrometry: data from 1.6 million newborns. (medlineplus.gov)
- Prospective Evaluation of a Matrix-assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry System in a Hospital Clinical Microbiology Laboratory for Identification of Bacteria and Yeasts: A Bench-by-bench Study for Assessing the Impact on Time to Identification and Cost-effectiveness. (beckmancoulter.com)
- Comparison of Two Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry Methods with Conventional Phenotypic Identification for Routine Identification of Bacteria to the Species Level. (beckmancoulter.com)
- A combination of direct analysis in real time (DART) ionization coupled to time-of-flight mass spectrometry (TOFMS) and chemometrics was used for animal fat (lard and beef tallow) authentication. (unboundmedicine.com)
- Urinary benzo[a]pyrene and its metabolites as molecular biomarkers of asphalt fume exposure characterized by microflow LC coupled to hybrid quadrupole time-of-flight mass spectrometry. (cdc.gov)
- This method is based on microflow liquid chromatography (LC) coupled to hybrid quadrupole orthogonal acceleration time-of-flight mass spectrometry (Q-TOFMS). (cdc.gov)
- In October 2022, Zimbabwe made the Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS) technology available for the clinical microbiology laboratory's quick and precise identification of bacteria, mycobacteria, and fungal infections. (who.int)
Inductively Coupled Plas3
-  The Inductively Coupled Plasma Mass Spectrometry is operated in the H mode. (wikipedia.org)
- What makes Inductively Coupled Plasma Mass Spectrometry (ICP-MS) unique to other forms of inorganic mass spectrometry is its ability to sample the analyte continuously, without interruption. (wikipedia.org)
- Title : Rapid determination of thorium in urine by quadrupole inductively coupled plasma mass spectrometry (Q-ICP-MS) Personal Author(s) : Liu, Yongzhong;Xiao, Ge;Jones, Robert L. (cdc.gov)
Ionization Mass Spectrometry5
- However, compared with other types of mass spectrometry, such as thermal ionization mass spectrometry (TIMS) and glow discharge mass spectrometry (GD-MS), ICP-MS introduces many interfering species: argon from the plasma, component gases of air that leak through the cone orifices, and contamination from glassware and the cones. (wikipedia.org)
- Glow Discharge Mass Spectrometry (GDMS) and Thermal Ionization Mass Spectrometry (TIMS), that require a two-stage process: Insert sample(s) into a vacuum chamber, seal the vacuum chamber, pump down the vacuum, energize sample, thereby sending ions into the mass analyzer. (wikipedia.org)
- A Resonance Ionization Spectroscopy/Resonance Ionization Mass Spectrometry Data Service. (nist.gov)
- TY - JOUR T1 - Authentication of animal fats using direct analysis in real time (DART) ionization-mass spectrometry and chemometric tools. (unboundmedicine.com)
- To perform MS-SG, natural libraries of glycans derived from glycoconjugates in cells or tissues are screened against a target GBP using catch-and-release electrospray ionization mass spectrometry ( CaR -ESI-MS). Because glycan concentrations are challenging to determine, ligand affinities cannot be directly measured. (bvsalud.org)
Electrospray mass spectro1
- Samples were analysed using a combination of CE alone, mass spectrometry alone and also coupled capillary electrophoresis/electrospray mass spectrometry (CE/ES). (open.ac.uk)
- Reproducible workflow for multiplexed deep-scale proteome and phosphoproteome analysis of tumor tissues by liquid chromatography-mass spectrometry. (broadinstitute.org)
- Gas chromatography - mass spectrometry (GC-MS) is the golden standard for the analysis of (semi) volatile organic compounds (VOCs). (ru.nl)
- Liquid chromatography mass spectrometry (LC-MS) is shown to provide high discriminating power for the identification of textile dyes that can not be reliably distinguished on the basis of their UV/visible absorption profile. (astm.org)
- 2019). 'Optimisation of a gas chromatography-mass spectrometry method for the simultaneous determination of tetrahydrocannabinol and its metabolites in rat urine', Arhiv za higijenu rada i toksikologiju , 70(4), str. (srce.hr)
- For this purpose, hydrolysis and solid phase extraction conditions of the investigated analytes were optimised and a gas chromatography-mass spectrometry (GC-MS) method was developed to determine all three analytes in rat urine. (srce.hr)
- The analytical methods used to measure benzidine and its metabolites in biological materials are GC (NIOSH 1984b), gas chromatography/mass spectrometry (GC/MS) (Hsu et al. (cdc.gov)
- Efficiency of database search for identification of mutated and modified proteins via mass spectrometry. (broadinstitute.org)
- In proteomic mass spectrometry the researchers first break up cancer cells, purify their proteins, and cut them up. (technologyreview.com)
- This mixture is put into the mass spectrometry machine, which sequences the proteins. (technologyreview.com)
- Mass spectrometry might be used during cancer drug development to assay a compound's effects on cancer cells' signaling proteins. (technologyreview.com)
- New methods and mass spectrometry instrumentation for the characterization of posttranslationally modified proteins and peptides will be presented. (selectbiosciences.com)
- The utility of mass spectrometry for peptides and proteins in clinical chemistry will be discussed, using amyloid peptides, tau protein and apolipoprotein E as examples. (selectbiosciences.com)
- These advances are made possible by preserving proteins in their native state in solution, followed by careful transfer into the gas phase of the mass spectrometer. (europeanpharmaceuticalreview.com)
- Once inside the mass spectrometer, individual protein-ligand complexes can be isolated and dissociated to provide ligand identification or to quantify the stabilisation that ligands provide upon binding to the proteins. (europeanpharmaceuticalreview.com)
- A schematic depicting how membrane proteins are studied using native mass spectrometer. (europeanpharmaceuticalreview.com)
- Thermo Scientific Orbitrap mass spectrometers in combination with enhanced sensitivity and throughput by multiplexing cells with TMT isobaric labelling allows their platforms to deliver more proteins per cell and from tens to hundreds of cells per day, going beyond one cell at a time. (cision.com)
- Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) offers superior mass resolving power and mass measurement accuracy, which is beneficial for the study of intact proteins and the characterisation of their posttranslational modifications (PTMs). (bl.uk)
- Mass spectrometry -based shotgun glycomics (MS-SG) is a rapid, sensitive, label-, and immobilization -free approach for the discovery of natural ligands of glycan - binding proteins (GBPs). (bvsalud.org)
- Nine proteins were identified by spectrometry. (who.int)
- To identify the analytes, experiments were carried out to couple CE with a mass spectrometer. (open.ac.uk)
- Instead, he suggests that the real value of using mass spectrometry to analyze a cell's protein content lies in the possibility for a dynamic understanding of how cancer cells behave in different stages of the disease. (technologyreview.com)
- One of his former students, a CDC employee, reached out to him to let him know that the branch she worked in was looking for a mass spectrometrist to analyze environmental and biological samples. (cdc.gov)
- A Mettler vacuum recording thermoanalyzer interfaced with a Finnigan Model 1050 quadrupole mass spectrometer is described and several applications using the system are given. (cdc.gov)
- Forest White , assistant professor of biological engineering at MIT, who uses mass spectrometry to study cell-signaling networks, is more cautious about direct clinical applications for the mass spectrometry technology: "It's hard to imagine a mass spec in every hospital," he says, because the results require expert interpretation. (technologyreview.com)
- White points out that even scientists with advanced biological research labs have trouble reading mass spectrometry results. (technologyreview.com)
- Discover the Centre for Biological Applications of Mass Spectrometry on the Canada Foundation for Innovation's Research Facilities Navigator. (concordia.ca)
- Thermospray techniques used in conjunction with mass spectrometry (MS) with or without high performance liquid chromatographic separation have proven useful for the determination of thermally labile compounds such as toxicant metabolites (Korfmacher et al. (cdc.gov)
- He was the head of the Mass Spectrometry Centre at Boehringer Ingelheim Pharmaceuticals in Argentina. (ulster.ac.uk)
- This led to the first publication that confirmed 11-βHSD1 as a novel therapeutic target for Alzheimer's disease which has revolutionised the field and became the European centre of excellence in steroid imaging by Mass Spectrometry. (ulster.ac.uk)
- Finally, he was appointed Director (SO) of Mass Spectrometry Centre at Ulster (BMRSI), where he is currently in charge of centre facilities and research support. (ulster.ac.uk)
- The Infinity series of laboratory gas generators are compressor-less nitrogen systems which have been engineered to provide gas to labs which already have an external source of air, and again is suitable for most mass spectrometers available on the market. (peakscientific.com)
- In this webinar, "The Use of MALDI-TOF in the Clinical Laboratory: Effectiveness and Challenges," Dr. Elizabeth Palavecino shares her laboratory's clinical experience with MALDI-TOF mass spectrometry. (beckmancoulter.com)
- MALDI-TOF mass spectrometry has emerged as a rapid, cost-efficient and clinically effective tool for identifying pathogens. (beckmancoulter.com)
- They know that to perform single cell analysis at scale our mass spectrometers in combination with TMT multiplexing is the way to go. (cision.com)
Chief scientific officer1
- The researchers were led by Brian Druker of the Oregon Health and Science University in Portland and Roberto Polakiewicz, chief scientific officer of Cell Signaling Technology in Danvers, MA. (technologyreview.com)
- Looking at a cell's actual molecular activity using mass spectrometry lets Druker avoid much of the guesswork in searching for cancer mechanisms. (technologyreview.com)
- He is a member of British Mass Spectrometry Society (BMSS), Royal Society of Chemistry (RSC), Endocrine Society, Society of Endocrinology, European Society of Molecular Imaging (Chair and editor) and member of advisory board committee of the Irish Mass Spectrometry Society. (ulster.ac.uk)
- The primary goal of the work described in this thesis was to employ FT-ICR mass spectrometry to investigate the molecular details of p53 redox-regulation. (bl.uk)
- Oregon researchers have used a new mass spectrometry technique to uncover a mutation that can cause leukemia. (technologyreview.com)
- Researchers can now pinpoint when early cultures began consuming animal milk and what kind of homemade glue was used to repair a punch bowl owned by George Washington's mother using new mass spectrometry chemical analysis techniques. (aaas.org)
- The new technique, called protein mass spectrometry, could uncover other drug targets and reveal how drugs affect cancer cells. (technologyreview.com)
- Protein mass spectrometry, in contrast, provides a clearer picture of what the cell is doing. (technologyreview.com)
- Protein mass spectrometry profiles of cells from a tumor biopsy could identify which protein is running amok and what drug would work best on it. (technologyreview.com)
- Hundreds of candidate protein biomarkers can be rapidly triaged, using MRM mass spectrometry, without the use of antibodies. (selectbiosciences.com)
- Mass spectrometry (MS) performed under native-like conditions (nMS) is a promising approach for studying protein-drug interactions, and has already informed treatments of some of the most intractable diseases including cancer, diabetes and Alzheimer's. (europeanpharmaceuticalreview.com)
- This allows the mass of protein and their bound ligands to be determined with high accuracy and resolution, elucidating not only their binding stoichiometry but also the capability to observe each species present in solution. (europeanpharmaceuticalreview.com)
- Two techniques of mass spectrometry were used within this thesis, fast atom bombardment and electrospray but only electrospray ionisation mass spectrometry was used to couple to capillary electrophoresis and was the only mass spectrometric technique used to analyse clinical and environmental samples. (open.ac.uk)
- Mass/charge ratio measurements were obtained for each analyte used and these allowed the unambiguous identification of each analyte. (open.ac.uk)
- An enrichment strategy was developed to purify oxidised p53 and top-down FT-ICR mass spectrometry revealed unambiguously that Cys176, 182, 238 and 242 were the oxidised residues. (bl.uk)
- Utilising this additional dimension of separation, it is possible to differentiate highly complex mixtures composed of species of equivalent mass, known as isobaric species, based on different conformations. (europeanpharmaceuticalreview.com)
- This involved complexing the diol with a boron-containing acid to produce an anion which could then be detected using ES and FAB mass spectrometric methods. (open.ac.uk)
- However, even though training facilities are available and mass spec companies have worked hard to make the 'software more straightforward', many still opt for bypassing the learning altogether and instead send their samples to a research facility that analyses the sample and send back the results. (peakscientific.com)
- In most cases the gas that feeds their mass spec is often the least of the scientists' worries - that is until they run out of gas mid analysis. (peakscientific.com)
- Is mass spectrometry analysis performed on oligos before shipped? (idtdna.com)
- Mass spectral records were processed by principal component analysis (PCA) and stepwise linear discriminant analysis (LDA). (unboundmedicine.com)
- Mass spectrometry is what Victor was trained for during his graduate work, so, not one to overlook an opportunity, he sent in his CV. (cdc.gov)
- multiple vacuum stages separate by differential apertures (holes), the ions created in the argon plasma are, with the aid of various electrostatic focusing techniques, transmitted through the mass analyzer to the detector(s) and counted. (wikipedia.org)
- In the article Perkel discusses the best way for novices to approach mass spectrometry experiments such as attending courses at facilities that offer open-access to instruments and step by step training to master key techniques. (peakscientific.com)
- CE instruments were successfully coupled to an electrospray mass spectrometer which then became the detector. (open.ac.uk)
- Mass Spectrometry-Based Shotgun Glycomics Using Labeled Glycan Libraries. (bvsalud.org)
- Druker's mass spectrometry study focused on acute myeloid leukemia, the most common form of the disease. (technologyreview.com)
- However, though mass spectrometry is highly accurate and fast, taking only minutes to convert a specimen into a result, it is not fully. (darkdaily.com)
- At the core of nMS is the ability to preserve non-covalent interactions and perform very accurate mass measurements. (europeanpharmaceuticalreview.com)
- mass spectrometry is often seen as a complicated and highly technical technique that requires years of experience to master. (peakscientific.com)
- Proteomic [mass spectrometry] gives you the true readout of what's going on in the cell," says Mark Cobbold, a clinician scientist at the University of Birmingham, U.K. (technologyreview.com)
- If you're looking for a mass spectrometrist who can develop a method for your particular project, I am your guy. (cdc.gov)
- Dr Diego Cobice has been working/contributing in the field of Mass Spectrometry (MS) from more than 20 years. (ulster.ac.uk)
- Other work involved using CE, ES and FAI3 mass spectrometry, to develop a new technique to detect diol containing compounds. (open.ac.uk)
- After 7 years in the pharmaceutical sector, he has moved to the University of Edinburgh (Medical School) to pursue a MSc in applied MS to cardiovascular diseases/risk factors using a novel MS modality called "Mass Spectrometry Imaging" (MSI). (ulster.ac.uk)