Mass Spectrometry
Tandem Mass Spectrometry
A mass spectrometry technique using two (MS/MS) or more mass analyzers. With two in tandem, the precursor ions are mass-selected by a first mass analyzer, and focused into a collision region where they are then fragmented into product ions which are then characterized by a second mass analyzer. A variety of techniques are used to separate the compounds, ionize them, and introduce them to the first mass analyzer. For example, for in GC-MS/MS, GAS CHROMATOGRAPHY-MASS SPECTROMETRY is involved in separating relatively small compounds by GAS CHROMATOGRAPHY prior to injecting them into an ionization chamber for the mass selection.
Spectrometry, Mass, Electrospray Ionization
A mass spectrometry technique used for analysis of nonvolatile compounds such as proteins and macromolecules. The technique involves preparing electrically charged droplets from analyte molecules dissolved in solvent. The electrically charged droplets enter a vacuum chamber where the solvent is evaporated. Evaporation of solvent reduces the droplet size, thereby increasing the coulombic repulsion within the droplet. As the charged droplets get smaller, the excess charge within them causes them to disintegrate and release analyte molecules. The volatilized analyte molecules are then analyzed by mass spectrometry.
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
A mass spectrometric technique that is used for the analysis of large biomolecules. Analyte molecules are embedded in an excess matrix of small organic molecules that show a high resonant absorption at the laser wavelength used. The matrix absorbs the laser energy, thus inducing a soft disintegration of the sample-matrix mixture into free (gas phase) matrix and analyte molecules and molecular ions. In general, only molecular ions of the analyte molecules are produced, and almost no fragmentation occurs. This makes the method well suited for molecular weight determinations and mixture analysis.
Gas Chromatography-Mass Spectrometry
Chromatography, High Pressure Liquid
Spectrometry, Mass, Secondary Ion
A mass-spectrometric technique that is used for microscopic chemical analysis. A beam of primary ions with an energy of 5-20 kiloelectronvolts (keV) bombards a small spot on the surface of the sample under ultra-high vacuum conditions. Positive and negative secondary ions sputtered from the surface are analyzed in a mass spectrometer in regards to their mass-to-charge ratio. Digital imaging can be generated from the secondary ion beams and their intensity can be measured. Ionic images can be correlated with images from light or other microscopy providing useful tools in the study of molecular and drug actions.
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Amino Acid Sequence
Spectrometry, Mass, Fast Atom Bombardment
A mass spectrometric technique that is used for the analysis of a wide range of biomolecules, such as glycoalkaloids, glycoproteins, polysaccharides, and peptides. Positive and negative fast atom bombardment spectra are recorded on a mass spectrometer fitted with an atom gun with xenon as the customary beam. The mass spectra obtained contain molecular weight recognition as well as sequence information.
Electrophoresis, Gel, Two-Dimensional
Deuterium Exchange Measurement
Peptides
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
Isotope Labeling
Molecular Structure
Peptide Mapping
Analysis of PEPTIDES that are generated from the digestion or fragmentation of a protein or mixture of PROTEINS, by ELECTROPHORESIS; CHROMATOGRAPHY; or MASS SPECTROMETRY. The resulting peptide fingerprints are analyzed for a variety of purposes including the identification of the proteins in a sample, GENETIC POLYMORPHISMS, patterns of gene expression, and patterns diagnostic for diseases.
Reproducibility of Results
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
Reference Standards
Calibration
Magnetic Resonance Spectroscopy
Solid Phase Extraction
Deuterium
Carbohydrate Sequence
Sensitivity and Specificity
Limit of Detection
Proteins
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
Ions
Body Mass Index
An indicator of body density as determined by the relationship of BODY WEIGHT to BODY HEIGHT. BMI=weight (kg)/height squared (m2). BMI correlates with body fat (ADIPOSE TISSUE). Their relationship varies with age and gender. For adults, BMI falls into these categories: below 18.5 (underweight); 18.5-24.9 (normal); 25.0-29.9 (overweight); 30.0 and above (obese). (National Center for Health Statistics, Centers for Disease Control and Prevention)
Metabolomics
Peptide Fragments
Substance Abuse Detection
Chromatography, Thin Layer
Chromatography, Gas
Fractionation of a vaporized sample as a consequence of partition between a mobile gaseous phase and a stationary phase held in a column. Two types are gas-solid chromatography, where the fixed phase is a solid, and gas-liquid, in which the stationary phase is a nonvolatile liquid supported on an inert solid matrix.
Fourier Analysis
Analysis based on the mathematical function first formulated by Jean-Baptiste-Joseph Fourier in 1807. The function, known as the Fourier transform, describes the sinusoidal pattern of any fluctuating pattern in the physical world in terms of its amplitude and its phase. It has broad applications in biomedicine, e.g., analysis of the x-ray crystallography data pivotal in identifying the double helical nature of DNA and in analysis of other molecules, including viruses, and the modified back-projection algorithm universally used in computerized tomography imaging, etc. (From Segen, The Dictionary of Modern Medicine, 1992)
Cyclotrons
Indicators and Reagents
Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)
Protein Processing, Post-Translational
Any of various enzymatically catalyzed post-translational modifications of PEPTIDES or PROTEINS in the cell of origin. These modifications include carboxylation; HYDROXYLATION; ACETYLATION; PHOSPHORYLATION; METHYLATION; GLYCOSYLATION; ubiquitination; oxidation; proteolysis; and crosslinking and result in changes in molecular weight and electrophoretic motility.
Isotopes
Analytic Sample Preparation Methods
Protein Binding
Trypsin
Metabolome
Electrophoresis, Polyacrylamide Gel
Glycosylation
Oligosaccharides
Sequence Analysis, Protein
Isomerism
Chromatography, Reverse-Phase
Oxidation-Reduction
A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).
Indicator Dilution Techniques
Cattle
Electrophoresis, Capillary
Models, Molecular
Complex Mixtures
Biotransformation
The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
Oxygen Isotopes
Gases
The vapor state of matter; nonelastic fluids in which the molecules are in free movement and their mean positions far apart. Gases tend to expand indefinitely, to diffuse and mix readily with other gases, to have definite relations of volume, temperature, and pressure, and to condense or liquefy at low temperatures or under sufficient pressure. (Grant & Hackh's Chemical Dictionary, 5th ed)
Chemical Fractionation
Biological Markers
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Spectrophotometry, Atomic
Microchemistry
Protein Array Analysis
Hydrogen
The first chemical element in the periodic table. It has the atomic symbol H, atomic number 1, and atomic weight [1.00784; 1.00811]. It exists, under normal conditions, as a colorless, odorless, tasteless, diatomic gas. Hydrogen ions are PROTONS. Besides the common H1 isotope, hydrogen exists as the stable isotope DEUTERIUM and the unstable, radioactive isotope TRITIUM.
Atmospheric Pressure
Nanotechnology
Algorithms
Spectrophotometry, Ultraviolet
Binding Sites
Spectroscopy, Fourier Transform Infrared
Glycosphingolipids
Lipids containing at least one monosaccharide residue and either a sphingoid or a ceramide (CERAMIDES). They are subdivided into NEUTRAL GLYCOSPHINGOLIPIDS comprising monoglycosyl- and oligoglycosylsphingoids and monoglycosyl- and oligoglycosylceramides; and ACIDIC GLYCOSPHINGOLIPIDS which comprises sialosylglycosylsphingolipids (GANGLIOSIDES); SULFOGLYCOSPHINGOLIPIDS (formerly known as sulfatides), glycuronoglycosphingolipids, and phospho- and phosphonoglycosphingolipids. (From IUPAC's webpage)
Chromatography, Affinity
Escherichia coli
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
Protein Conformation
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
Phosphorylation
Databases, Protein
Methylation
Sequence Homology, Amino Acid
Glycomics
Chromatography, Ion Exchange
Chemistry Techniques, Analytical
Models, Chemical
Carbon Isotopes
Cross-Linking Reagents
Reagents with two reactive groups, usually at opposite ends of the molecule, that are capable of reacting with and thereby forming bridges between side chains of amino acids in proteins; the locations of naturally reactive areas within proteins can thereby be identified; may also be used for other macromolecules, like glycoproteins, nucleic acids, or other.
Substrate Specificity
Protein Structure, Tertiary
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
Software
Stereoisomerism
Blood Proteins
Volatile Organic Compounds
Amino Acids
Nitrogen Isotopes
Disulfides
Glucuronides
Glycosides of GLUCURONIC ACID formed by the reaction of URIDINE DIPHOSPHATE GLUCURONIC ACID with certain endogenous and exogenous substances. Their formation is important for the detoxification of drugs, steroid excretion and BILIRUBIN metabolism to a more water-soluble compound that can be eliminated in the URINE and BILE.
Base Sequence
Blotting, Western
Hydrogen-Ion Concentration
Fatty Acids
Glycopeptides
Carbohydrates
Solid Phase Microextraction
Brain Chemistry
Mutation
Lipids
A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)
Glycerophospholipids
Derivatives of phosphatidic acid in which the hydrophobic regions are composed of two fatty acids and a polar alcohol is joined to the C-3 position of glycerol through a phosphodiester bond. They are named according to their polar head groups, such as phosphatidylcholine and phosphatidylethanolamine.
Hair
Neonatal Screening
The identification of selected parameters in newborn infants by various tests, examinations, or other procedures. Screening may be performed by clinical or laboratory measures. A screening test is designed to sort out healthy neonates (INFANT, NEWBORN) from those not well, but the screening test is not intended as a diagnostic device, rather instead as epidemiologic.
Glycolipids
Immunoassay
Sequence Alignment
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
Immunoprecipitation
Specimen Handling
Hydroxylation
Sequence Analysis
Models, Biological
Volatilization
Solvents
Computational Biology
A field of biology concerned with the development of techniques for the collection and manipulation of biological data, and the use of such data to make biological discoveries or predictions. This field encompasses all computational methods and theories for solving biological problems including manipulation of models and datasets.
Microsomes, Liver
Metabolism, Inborn Errors
Chromatography
Techniques used to separate mixtures of substances based on differences in the relative affinities of the substances for mobile and stationary phases. A mobile phase (fluid or gas) passes through a column containing a stationary phase of porous solid or liquid coated on a solid support. Usage is both analytical for small amounts and preparative for bulk amounts.
Chromatography, Gel
Proteolysis
Plant Proteins
Liver
Principal Component Analysis
Trifluoroacetic Acid
Alkylation
Plant Extracts
Lasers
An optical source that emits photons in a coherent beam. Light Amplification by Stimulated Emission of Radiation (LASER) is brought about using devices that transform light of varying frequencies into a single intense, nearly nondivergent beam of monochromatic radiation. Lasers operate in the infrared, visible, ultraviolet, or X-ray regions of the spectrum.
DNA Adducts
Quality Control
Horses
Protein Isoforms
Temperature
Molecular Imaging
Glycoproteins
Doping in Sports
Multiprotein Complexes
Cloning, Molecular
Pharmaceutical Preparations
Radioisotope Dilution Technique
Rats, Sprague-Dawley
Membrane Proteins
Urinalysis
Electrons
Stable elementary particles having the smallest known negative charge, present in all elements; also called negatrons. Positively charged electrons are called positrons. The numbers, energies and arrangement of electrons around atomic nuclei determine the chemical identities of elements. Beams of electrons are called CATHODE RAYS.
Glycosides
Any compound that contains a constituent sugar, in which the hydroxyl group attached to the first carbon is substituted by an alcoholic, phenolic, or other group. They are named specifically for the sugar contained, such as glucoside (glucose), pentoside (pentose), fructoside (fructose), etc. Upon hydrolysis, a sugar and nonsugar component (aglycone) are formed. (From Dorland, 28th ed; From Miall's Dictionary of Chemistry, 5th ed)
Species Specificity
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
Liquid-Liquid Extraction
Monosaccharides
Spectrophotometry, Infrared
Solutions
Metals
Two-Dimensional Difference Gel Electrophoresis
Spectrum Analysis
Methanol
Veterinary Drugs
Drugs used by veterinarians in the treatment of animal diseases. The veterinarian's pharmacological armamentarium is the counterpart of drugs treating human diseases, with dosage and administration adjusted to the size, weight, disease, and idiosyncrasies of the species. In the United States most drugs are subject to federal regulations with special reference to the safety of drugs and residues in edible animal products.
Cells, Cultured
Amides
Protein Subunits
Californium
Trimethylsilyl Compounds
Swine
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
Environmental Monitoring
Chemistry
Metabolic Networks and Pathways
Tumor Markers, Biological
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
Glucuronates
Coumaric Acids
Cluster Analysis
A set of statistical methods used to group variables or observations into strongly inter-related subgroups. In epidemiology, it may be used to analyze a closely grouped series of events or cases of disease or other health-related phenomenon with well-defined distribution patterns in relation to time or place or both.
DNA
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Less common "doping" agents and substances encountered during routine screening for drugs. (1/17751)
The chromatographic and spectroscopic properties of several unusual substances which have been detected in the "alkaloidal" chloroform extract from racehorse urine and saliva samples are reported. Some of these substances have been identified by combined gas chromatography-mass spectrometry and the source of the substance is stated where this is known. Other substances whose identity is not known have been detected and their mass spectra show characteristic amine fragments. The occurrence of these unidentified substances is more frequent in aged urine samples and it would therefore appear that they are associated with putrefaction. (+info)Urinary lithium: distribution shape, reference values, and evaluation of exposure by inductively coupled plasma argon-emission spectrometry. (2/17751)
Inductively coupled plasma argon-emission spectrometry (ICPAES) was used to evaluate the lithium content of undiluted urine samples. The method can be performed with 1 mL of urine in a single tube using a routine ICPAES analysis for rapid and convenient assessment of lithium exposure in humans. Urine samples obtained from male workers (n = 86) who had not been exposed to lithium were used for the determination of this element by ICPAES. The obtained concentrations were corrected using a specific gravity of 1.024. The particular frequency distribution resulted in a log-normal distribution diagram for anatomical spread. Geometric mean value for urinary lithium in the nonexposed male workers was 23.5 microg/L, and the confidence interval from a log-normal distribution was 11.0 to 50.5 microg/L. Taking into consideration a short biological half-life and the massive urine excretion of lithium, urinary lithium was considered to be a useful index for monitoring of exposure. Calibration curves obtained for lithium standards had good sensitivity and linearity. Good reproducibility was assessed by lithium addition to urine samples. It was concluded that the obtained lithium reference values would be useful for the early diagnosis of lithium intoxication or in the assessment of the degree of exposure to lithium in subjects at risk. (+info)Archive of mass spectral data files on recordable CD-ROMs and creation and maintenance of a searchable computerized database. (3/17751)
A database containing names of mass spectral data files generated in a forensic toxicology laboratory and two Microsoft Visual Basic programs to maintain and search this database is described. The data files (approximately 0.5 KB/each) were collected from six mass spectrometers during routine casework. Data files were archived on 650 MB (74 min) recordable CD-ROMs. Each recordable CD-ROM was given a unique name, and its list of data file names was placed into the database. The present manuscript describes the use of search and maintenance programs for searching and routine upkeep of the database and creation of CD-ROMs for archiving of data files. (+info)UV irradiation of polycyclic aromatic hydrocarbons in ices: production of alcohols, quinones, and ethers. (4/17751)
Polycyclic aromatic hydrocarbons (PAHs) in water ice were exposed to ultraviolet (UV) radiation under astrophysical conditions, and the products were analyzed by infrared spectroscopy and mass spectrometry. Peripheral carbon atoms were oxidized, producing aromatic alcohols, ketones, and ethers, and reduced, producing partially hydrogenated aromatic hydrocarbons, molecules that account for the interstellar 3.4-micrometer emission feature. These classes of compounds are all present in carbonaceous meteorites. Hydrogen and deuterium atoms exchange readily between the PAHs and the ice, which may explain the deuterium enrichments found in certain meteoritic molecules. This work has important implications for extraterrestrial organics in biogenesis. (+info)Relationship between UDP-glucose 4-epimerase activity and oligoglucose glycoforms in two strains of Neisseria meningitidis. (5/17751)
Sodium dodecyl sulfate-polyacrylamide gel analysis of lipooligosaccharide (LOS) from Neisseria meningitidis has demonstrated considerable microheterogeneity in the variable region of LOS due to the presence of novel glycoforms. As a step toward understanding the basis for the expression of these novel glycoforms, we have examined the LOS structures and UDP-glucose 4-epimerase (epimerase) activity levels in two strains (NMB and MA-1) and their respective galE mutants. Strain NMB was found to have low epimerase activity and to contain multiple glycoforms, some of which appear to contain only glucose sugars. The galE mutant had only the oligoglucose glycoforms. Strain MA-1 had higher epimerase activity at both log and stationary phases (2- and 12.5-fold, respectively) and one glycoform with a putative lactosyl structure. Strain MA-1 galE had two glycoforms that contained one or two glucose residues. To understand the molecular basis for the different epimerase activities, we examined the predicted amino acid sequences of the respective galE open reading frames and determined the relative amounts of GalE protein. We found no significant differences between the predicted amino acid sequence of the GalE protein in NMB and that in MA-1. We observed no significant differences in the level of GalE protein between MA-1 and NMB at exponential or stationary phase. We also observed an 8.2-fold drop in epimerase activity in NMB between the log and stationary phases that was not due to the GalE protein level or low glucose levels. (+info)Insulin-like growth factors I and II are unable to form and maintain their native disulfides under in vivo redox conditions. (6/17751)
Insulin-like growth factor (IGF) I does not quantitatively form its three native disulfide bonds in the presence of 10 mM reduced and 1 mM oxidized glutathione in vitro [Hober, S. et al. (1992) Biochemistry 31, 1749-1756]. In this paper, we show (i) that both IGF-I and IGF-II are unable to form and maintain their native disulfide bonds at redox conditions that are similar to the situation in the secretory vesicles in vivo and (ii) that the presence of protein disulfide isomerase does not overcome this problem. The results indicate that the previously described thermodynamic disulfide exchange folding problem of IGF-I in vitro is also present in vivo. Speculatively, we suggest that the thermodynamic disulfide exchange properties of IGF-I and II are biologically significant for inactivation of the unbound growth factors by disulfide exchange reactions to generate variants destined for rapid clearance. (+info)Purification and identification of a novel subunit of protein serine/threonine phosphatase 4. (7/17751)
The catalytic subunit of protein serine/threonine phosphatase 4 (PP4C) has greater than 65% amino acid identity to the catalytic subunit of protein phosphatase 2A (PP2AC). Despite this high homology, PP4 does not appear to associate with known PP2A regulatory subunits. As a first step toward characterization of PP4 holoenzymes and identification of putative PP4 regulatory subunits, PP4 was purified from bovine testis soluble extracts. PP4 existed in two complexes of approximately 270-300 and 400-450 kDa as determined by gel filtration chromatography. The smaller PP4 complex was purified by sequential phenyl-Sepharose, Source 15Q, DEAE2, and Superdex 200 gel filtration chromatographies. The final product contained two major proteins: the PP4 catalytic subunit plus a protein that migrated as a doublet of 120-125 kDa on SDS-polyacrylamide gel electrophoresis. The associated protein, termed PP4R1, and PP4C also bound to microcystin-Sepharose. Mass spectrometry analysis of the purified complex revealed two major peaks, at 35 (PP4C) and 105 kDa (PP4R1). Amino acid sequence information of several peptides derived from the 105 kDa protein was utilized to isolate a human cDNA clone. Analysis of the predicted amino acid sequence revealed 13 nonidentical repeats similar to repeats found in the A subunit of PP2A (PP2AA). The PP4R1 cDNA clone engineered with an N-terminal Myc tag was expressed in COS M6 cells and PP4C co-immunoprecipitated with Myc-tagged PP4R1. These data indicate that one form of PP4 is similar to the core complex of PP2A in that it consists of a catalytic subunit and a "PP2AA-like" structural subunit. (+info)Identification of 17-methyl-18-norandrosta-5,13(17-dien-3beta-ol, the C19 fragment formed by adrenal side chain cleavage of a 20-aryl analog of (20S)-20-hydroxycholesterol. (8/17751)
Incubation of (20R)-20-phenyl-5-pregnene-3beta,20-diol, an aromatic analog of (23S)-20-hydroxycholesterol, with an adrenal mitochondrial preparation leads to the formation of four compounds: pregnenolone, phenol, a C8 ketone, acetophenone, and a nonpolar C19 compound. This latter compound has now been identified by reverse isotope dilution analysis and by gas chromatography/mass spectrometry as 17-methyl-18-norandrosta-5,13(17)-dien-3beta-ol. From these results it is evident that enzymatic fission of the C-17,20 bond of this synthetic derivative occurs. On the other hand, when (20S)-20-hydroxy[21-14C]cholesterol was used as substrate, the analogous cleavage did not take place. Thus, substitution of an aromatic group on C-20 facilitates side chain cleavage between that carbon atom and the nucleus whereas neither of the naturally occuring precursors, cholesterol or its 20-hydroxylated counterpart, are metabolized to a C8 fragment. (+info)
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EP 0985148 A1 20000315 - NUCLEIC ACID DIAGNOSTICS BASED ON MASS SPECTROMETRY OR MASS SEPARATION AND BASE SPECIFIC CLEAVAGE
A mass accuracy sensitive probability based scoring algorithm for database searching of tandem mass spectrometry data | BMC...
Gel permeation chromatography coupled to fourier transform mass spectrometry for polymer characterization - Fingerprint
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High Resolution Mass Spectrometry (HRMS) - Organics | Sigma-Aldrich
A theoretical and mass spectrometry study of the fragmentation of mycosporine-like amino acids<...
Determination of toxaphene in fish samples - a congener specific approach using high resolution mass spectrometry<...
Advances in imaging secondary ion mass spectrometry for biological samples (Journal Article) | DOE PAGES
OPUS 4 | Recent advances in capillary electrophoresis-mass spectrometry
Collision cross section calculations for polyatomic ions considering rotating diatomic/linear gas molecules (Journal Article) |...
Attomole Protein Characterization by Capillary Electrophoresis-Mass Spectrometry | Science
Mining gene functional networks to improve mass-spectrometry-based protein identification<...
PART I: FIELD DESORPTION MASS SPECTROMETRY OF ALKALI METAL CRYPTATES. by MEI-KUEN. AU
Ion Mobility-Mass Spectrometry in the -Omics
Figure 1 | Estimation of Ion Competition via Correlated Responsivity Offset in Linear Ion Trap Mass Spectrometry Analysis:...
Combination of1H nuclear magnetic resonance spectroscopy and liquid chromatography/mass spectrometry with pattern recognition...
Methods and Algorithms for Quantitative Proteomics by Mass Spectrometry<...
Automated Analysis of Complex Carbohydrates via Ion Mobility-Mass Spectrometry :: MPG.PuRe
Titanium pre-sputtering for an enhanced secondary ion mass spectrometry analysis of atmospheric gas elements - Journal of...
Peak picking as a pre-processing technique for imaging time of flight secondary ion mass spectrometry
Book) Secondary ion mass spectrometry, SIMS X by International Conference on Secondary Ion Mass Spectrometry (10th 1995...
Multi-isotope imaging mass spectrometry reveals slow protein turnover in hair-cell stereocilia<...
Quantitative analysis of polypeptide pharmaceuticals by matrix-assisted laser desorption/ionization time-of-flight mass...
How does high resolution mass spectrometry compare to tandem mass spectrometry for broad spectrum drug screening?
Dynamic Secondary Ion Mass Spectrometry | Imaging & Microscopy - Research, Development, Production
Clinical Mass Spectrometry Market Report 2018: Segmentation
Quantitation of the anticancer drug abiraterone and its metabolite Δ(4)-abiraterone in human plasma using high-resolution mass...
Probing conformational changes of ubiquitin by host-guest chemistry using electrospray ionization mass spectrometry<...
Matrix-assisted nanoelectrospray mass spectrometry for soft ionization of metal(i)-protein complexes - Analyst (RSC Publishing)
An evaluation of the utility of in vacuo methylation for mass-spectrometry-based analyses of peptides<...
Targeted peptide measurements in biology and medicine: Best practices for mass spectrometry-based assay development using a fit...
Fast atom bombardment mass spectrometry of bouvardin and selected analogs
Data Availability StatementThe mass spectrometry proteomics data have already been deposited towards the ProteomeXchange...
A combination of molecular probe-tandem electrospray ionization mass spectrometry: A technique for tracing structural changes...
Method Development Considerations for Paper Spray Mass Spectrometry - Direct Ionization Technique for Physiological Fluid...
DNA sequencing
Sequencing with mass spectrometry[edit]. Mass spectrometry may be used to determine DNA sequences. Matrix-assisted laser ... The mass of each nucleotide is different from the others and this difference is detectable by mass spectrometry. Single- ... Edwards JR, Ruparel H, Ju J (2005). "Mass-spectrometry DNA sequencing". Mutation Research. 573 (1-2): 3-12. doi:10.1016/j. ... Monforte JA, Becker CH (1 March 1997). "High-throughput DNA analysis by time-of-flight mass spectrometry". Nature Medicine. 3 ( ...
Penning trap
... also known as Fourier transform mass spectrometry) is a type of mass spectrometry used for determining the mass-to-charge ratio ... Fourier transform ion cyclotron resonance mass spectrometry: a primer. Mass Spectrom Rev 17, 1-35. ... Fourier transform mass spectrometry[edit]. Main article: Fourier transform ion cyclotron resonance ... High-precision mass determination of unstable nuclei with a Penning trap mass spectrometer at ISOLDE/CERN, Switzerland ...
Cardiac amyloidosis
Mass Spectrometry[edit]. Mass spectrometry can be used to determine whether the protein is light-chain or familial amyloidosis ...
Gas chromatography-mass spectrometry
"Early gas chromatography/mass spectrometry". Journal of the American Society for Mass Spectrometry. 4 (5): 367-371. doi:10.1016 ... Gas chromatography-mass spectrometry (GC-MS) is an analytical method that combines the features of gas-chromatography and mass ... Amirav A, Gordin A, Poliak M, Fialkov AB (2008). "Gas chromatography-mass spectrometry with supersonic molecular beams". J Mass ... Pyrolysis-gas chromatography-mass spectrometry. References[edit]. *^ O. David Sparkman; Zelda Penton; Fulton G. Kitson (17 May ...
J. J. Thomson
In 1991, the thomson (symbol: Th) was proposed as a unit to measure mass-to-charge ratio in mass spectrometry in his honour.[28 ... J.J. Thomson's separation of neon isotopes by their mass was the first example of mass spectrometry, which was subsequently ... Isotopes and mass spectrometry[edit]. In the bottom right corner of this photographic plate are markings for the two isotopes ... were the first use of mass spectrometry and led to the development of the mass spectrograph.[2] ...
Spark ionization
This technique is primarily used in the field of mass spectrometry. When incorporated with a mass spectrometer the complete ... Spark source mass spectrometry (SSMS)[edit]. The rf spark source creates ions with a wide energy spread (2-3 kV), which ... H. E. Beske, A. Hurrle and K. P. Jochum (1981). "Part I. Principles of spark source mass spectrometry (SSMS)". Fresenius' ... Review and Evaluation of Spark Source Mass Spectrometry as an Analytical Method". Fresenius' Zeitschrift für Analytische Chemie ...
Cold Spring Harbor Laboratory
... mass spectrometry; advanced microscopy. Cancer Research. Principal cancer types under study: breast, prostate, blood (leukemia ...
User:Plbrown123/Books/Atoms, Ions, Bonds, Molecules, Electronic, and Chemical Analysis; You Don't See that in Dasher! -...
Mass Spectrometry. Mass spectrometry. Fast atom bombardment. Electron ionization. Chemical ionization. Electrospray ionization ... Quadrupole mass analyzer. Time-of-flight mass spectrometry. Electron multiplier. Faraday cup. Carbon-13. Infrared multiphoton ...
Glycoprotein
Mass spectrometry Provides information on molecular mass, composition, sequence, and sometimes branching of a glycan chain. It ... Dell A (2001). "Glycoprotein Structure Determination by Mass Spectrometry". Science. 291 (5512): 2351-2356. Bibcode:2001Sci... ... The viral spike of the human immunodeficiency virus is heavily glycosylated.[8] Approximately half the mass of the spike is ... provides information on molecular mass, protein-carbohydrate ratio, aggregation state, size, and sometimes branching of a ...
User:Rirunmot/User:Rirunmot/subpage7
Mass spectrometry: Used to determine the molecular weight of a compound and from mass spectrum analysis its structure. High ... See also mass spectrometry, below.. *Infrared spectroscopy: Chiefly used to determine the presence (or absence) of certain ... resolution mass spectrometry can often identify the precise formula of a compound through knowledge of isotopic masses and ... In practice, small molecules have a molar mass less than approximately 1000 g/mol. ...
Effects of cannabis
Biological Mass Spectrometry. 7 (6): 247-56. doi:10.1002/bms.1200070605.. *^ a b c d J.E. Joy; S. J. Watson, Jr.; J.A. Benson, ... Fonseca BM, Correia-da-Silva G, Almada M, Costa MA, Teixeira NA; Correia-Da-Silva; Almada; Costa; Teixeira (2013). "The ... A 2000 study by researchers at Boston's Beth Israel Deaconess Medical Center, Massachusetts General Hospital and Harvard School ... Lyons, Casey (October 2012) Lost in the Weeds: Legalizing Medical Marijuana in Massachusetts. Boston Magazine. ...
Ecgonidine
Journal of Mass Spectrometry. 1999 Jun;34(6):651-60.. ... Coca alkaloids Scheidweiler KB, Shojaie J, Plessinger MA, Wood ... Electron ionization mass fragmentometric detection of urinary ecgonidine, a hydrolytic product of methylecgonidine, as an ...
2C-T-2
... studies on its metabolism and toxicological detection in rat urine using gas chromatography/mass spectrometry". Journal of Mass ...
Bendix Corporation
"Gas Chromatography-Mass Spectrometry". American Chemical Society. Retrieved 19 Nov 2019.. *^ "Marine Surplus Seller, Issues 13- ... Beginning in the 1960s, Bendix produced scientific instruments such as the Bendix MA-2 Time-of-Flight Mass Spectrometer.[12] ... Harrington of Bendix Aviation in the 1950s led to the combination of gas chromatography and mass spectrometry, and the ... development of Gas chromatography-mass spectrometry instrumentation. ...
Phosphorylation
"Int J Mass Spectrometry. 367: 28-34. Bibcode:2014IJMSp.367...28G. doi:10.1016/j.ijms.2014.04.015. PMC 4375673. PMID 25844054.. ... More recently large-scale mass spectrometry analyses have been used to determine sites of protein phosphorylation. Over the ... However, the analysis of phosphorylated peptides by mass spectrometry is still not as straightforward as for "regular", ... Advanced, highly accurate mass spectrometers are needed for these studies, limiting the technology to labs with high-end mass ...
Desmethylflunitrazepam
Journal of Mass Spectrometry. 51 (11): 1080-1089. doi:10.1002/jms.3840. ISSN 1096-9888. PMID 27535017.. ...
Enobosarm
Mass spectrometry of hydantoin-derived selective androgen receptor modulators. Journal of Mass Spectrometry. 2008 May;43(5):639 ...
PCPr
Journal of Mass Spectrometry. 43 (3): 305-16. doi:10.1002/jms.1312. PMID 17968862.. ... in rat urine using gas chromatography-mass spectrometry". Journal of Chromatography A. 1186 (1-2): 380-90. doi:10.1016/j.chroma ... in rat urine using gas chromatography-mass spectrometry". Forensic Science International. 181 (1-3): 47-51. doi:10.1016/j. ... Studies on their metabolism and toxicological detection in rat urine using gas chromatographic/mass spectrometric techniques". ...
Yohimbine
Rapid Communications in Mass Spectrometry. 25 (18): 2591-602. doi:10.1002/rcm.5158. PMID 23657953.. ... including mass spectrometry, UV absorption, IR absorption, and NMR, established that quebrachine and yohimbine are one and the ... Molar mass. 354.44 g/mol (base). 390.90 g/mol (hydrochloride) g·mol−1. ... yohimbe bark with ultra-performance liquid chromatography coupled with ion mobility quadrupole time-of-flight mass spectrometry ...
Methylenedioxypyrovalerone
... by gas chromatography/mass spectrometry and liquid chromatography/quadrupole time-of-flight mass spectrometry". Rapid ... plasma or urine by gas chromatography-mass spectrometry or liquid chromatography-mass spectrometry to confirm a diagnosis of ... Journal of Mass Spectrometry. 45 (12): 1426-42. doi:10.1002/jms.1859. PMID 21053377. Baselt RC (2014). Disposition of toxic ... Communications in Mass Spectrometry. 24 (18): 2706-14. doi:10.1002/rcm.4692. PMID 20814976. Michaelis, W.; Russel, J. H.; ...
Theanine
Rapid Communications in Mass Spectrometry. 18 (3): 251-6. doi:10.1002/rcm.1319. PMID 14755608.. ... underivatized theanine enantiomers by high-performance liquid chromatography/atmospheric pressure ionization-mass spectrometry ...
Proton
Gabrielse, G. (2006). "Antiproton mass measurements". International Journal of Mass Spectrometry. 251 (2-3): 273-280. Bibcode: ... current quark mass refers to the mass of a quark by itself, while constituent quark mass refers to the current quark mass plus ... of the mass. The rest mass of a proton is, thus, the invariant mass of the system of moving quarks and gluons that make up the ... see mass in special relativity). A proton has a mass of approximately 938 MeV/c2, of which the rest mass of its three valence ...
Omics
Mass spectrometry techniques are used.. Proteomics[edit]. Proteome is the entire complement of proteins, including the ... Mass spectrometry techniques are used. *Immunoproteomics: study of large sets of proteins (proteomics) involved in the immune ... Uses proteomics mass spectrometry data for protein expression studies. *Proteogenomics: An emerging field of biological ... typically using imaging mass spectrometry data.[13]. *Ethomics: Is the high-throughput machine measurement of animal behaviour. ...
Nicotiana tabacum
Rapid Communications in Mass Spectrometry. 32 (20): 1791-1798. Bibcode:2018RCMS...32.1791Z. doi:10.1002/rcm.8222. PMID 29964303 ... Journal of the American Society for Mass Spectrometry, Volume 18, Issue 10, October 2007, Pages 1774-1782 ... Determination of Pyridine Alkaloids in Tobacco by PFTBA Ions/Analyte Molecule Reaction Ionization Ion Trap Mass Spectrometry, ... by dispersive solid-phase extraction coupled with ultra-performance liquid chromatography/Tandem orbitrap mass spectrometry". ...
Elastic recoil detection
Mass resolution[edit]. In a similar way mass resolution is a parameter that characterizes the capability of recoil spectrometry ... Dynamic Secondary Ion Mass Spectrometry DSIMS 1012 - 1016 atoms/cm3[7] 2 - 30 nm[7] 50 nm to 2 µm[7] Elemental Depth Profile ... The E2 transferred by projectile ions of mass m1 and energy E1 to sample atoms of mass m2 recoiling at an angle ϕ, with respect ... 9)[19] with a recoil angle of Φ.[19] The variable r is the ratio of mass of the incident nuclei to that of the mass of the ...
Methylenedioxypyrovalerone
... by gas chromatography/mass spectrometry and liquid chromatography/quadrupole time-of-flight mass spectrometry". Rapid ... plasma or urine by gas chromatography-mass spectrometry or liquid chromatography-mass spectrometry to confirm a diagnosis of ... Journal of Mass Spectrometry. 45 (12): 1426-42. Bibcode:2010JMSp...45.1426M. doi:10.1002/jms.1859. PMID 21053377.. ... Communications in Mass Spectrometry. 24 (18): 2706-14. Bibcode:2010RCMS...24.2706S. doi:10.1002/rcm.4692. PMID 20814976.. ...
Cyclopropanetrione
However it has been detected using mass spectrometry. It is the neutral equivalent of the deltate anion C3O32−, known since ... International Journal of Mass Spectrometry. 188 (1-2): 17-25. Bibcode:1999IJMSp.188...17S. doi:10.1016/S1387-3806(98)14208-2. ... Schröder, Detlef; Helmut Schwarz; Suresh Dua; Stephen J. Blanksby; John H. Bowie (1999). "Mass spectrometric studies of the ... Skujins, S.; J. Delderfield, G.A. Webb (1968). "A mass spectrometric study of some monocyclic polycarbonyl compounds". ...
Volatile organic compound
Ellis, Andrew M.; Mayhew, Christopher A. (2014). Proton Transfer Reaction Mass Spectrometry - Principles and Applications. ... Direct injection mass spectrometry techniques are frequently utilized for the rapid detection and accurate quantification of ... International Journal of Mass Spectrometry. 368: 1-5. Bibcode:2014IJMSp.368....1S. doi:10.1016/j.ijms.2014.05.004.. ... "Direct-injection mass spectrometry adds the time dimension to (B)VOC analysis". Trends in Analytical Chemistry. 30 (7): 1003- ...
Alpha hydroxy acid
"Rapid Communications in Mass Spectrometry. 30 (18): 2043-2051. doi:10.1002/rcm.7684. ISSN 0951-4198.. ... "Quantitation of α-hydroxy acids in complex prebiotic mixtures via liquid chromatography/tandem mass spectrometry". ...
Molecular sensor
"The potential of ion mobility mass spectrometry for tuning synthetic host guest systems: A case study using novel zinc(II) ... dipicolylamine anion sensors". International Journal of Mass Spectrometry. Bibcode:2015IJMSp.391...62N. doi:10.1016/j.ijms. ...
Lewis Joel Greene
"Proton transfer mass spectrometry of peptides. A rapid heating technique for underivatized peptides containing arginine" (PDF) ...
質譜法 - 維基百科,自由的百科全書
離子遷移光譜-質譜法(英語:on-mobility spectrometry-mass spectrometry)(IMS/MS,或IMMS)是一種技術,在引入質譜儀之前,離子首先通過一些中性氣體在施加的電勢梯度下通過漂移時間分離[6] 。漂移時間是相對 ... Peptide and protein analysis by electrospray ionization-mass spectrometry and capillary electrophoresis-mass spectrometry. ... 生物質譜分
ZP3
2004). "Mass spectrometry analysis of recombinant human ZP3 expressed in glycosylation-deficient CHO cells". Biochemistry. 43 ( ...
Apolipoprotein C4
... and mass spectrometry". J. Proteome Res. 4 (6): 2070-80. doi:10.1021/pr0502065. PMC 1850943 . PMID 16335952.. ... "Molecular medicine (Cambridge, Mass.). 16 (9-10): 389-99. doi:10.2119/molmed.2010.00044. PMC 2935949 . PMID 20498921.. ... Liu T, Qian WJ, Gritsenko MA, et al. (2005). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide ...
Stevens Institute of Technology
Center for Mass Spectrometry. Stevens har samarbeid med Kongsbergindustrien og de norske institusjonene NTNU, Høgskolen i ...
PDLIM1 - ويكيبيديا، الموسوعة الحرة
... tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry ... Ostendorff HP، Peirano RI، Peters MA، Schlüter A، Bossenz M، Scheffner M، Bach I (2002). "Ubiquitination-dependent cofactor ... "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat ...
Quercetin
... of flavonoids in honey by HPLC coupled with coulometric electrode array detection and electrospray ionization mass spectrometry ... Feitelson MA, Arzumanyan A, Kulathinal RJ, Blain SW, Holcombe RF, Mahajna J, Marino M, Martinez-Chantar ML, Nawroth R, Sanchez- ... Barnes S, Prasain J, D'Alessandro T, Arabshahi A, Botting N, Lila MA, Jackson G, Janle EM, Weaver CM (May 2011). "The ...
Fluorescence in situ hybridization
MA-FISH[edit]. Microfluidics-assisted FISH (MA-FISH) uses a microfluidic flow to increase DNA hybridization efficiency, ... MA-FISH is applied for detecting the HER2 gene in breast cancer tissues.[16] ...
Bioinformática, a enciclopedia libre
"Bioinformatics in mass spectrometry data analysis for proteomics studies". Expert Review of Proteomics 1 (4). Páxs. 469-483.. ...
Benzo(a)pyrene
... pyrene in Human Bronchoalveolar H358 Cells Using Liquid Chromatography-Mass Spectrometry". Chem. Res. Toxicol. 20 (9): 1331- ... Clark RS, Pellom ST, Booker B, Ramesh A, Zhang T, Shanker A, Maguire M, Juarez PD, Patricia MJ, Langston MA, Lichtveld MY, Hood ...
Brix
The refractive index, nD, for sucrose solutions of various percentage by mass has been measured and tables of nD vs. °Bx ... Fourier Transform Infrared Spectrometry) techniques. In the former case, in-line instruments are available which allow constant ... If using the ICUMSA tables,[4] he or she would report in mass fraction (m.f.). It is not, typically, actually necessary to ... For example, an 11.0% by mass D-Glucose ("grape sugar") solution measured 10.9 °Bx using a hand held instrument.[citation ...
Parrot
Feral parrot flocks can be formed after mass escapes of newly imported, wild-caught parrots from airports or quarantine ... Revealed by Multiple-angle Spectrometry". Journal of Avian Medicine and Surgery. 20 (1): 8-14. doi:10.1647/1082-6742(2006)20[8: ...
HADHB
... encodes a 51.2 kDa protein that is composed of 474 amino acids; 124 peptides have been observed through mass spectrometry ... 2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides ...
Amine
Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as ...
Molecular mass
Mass spectrometryEdit. Main article: Mass spectrometry. In mass spectrometry, the molecular mass of a small molecule is usually ... Not to be confused with Molar mass or Mass number.. The molecular mass (m) is the mass of a given molecule: it is measured in ... The molecular mass and relative molecular mass are distinct from but related to the molar mass. The molar mass is defined as ... The molecular mass of small to medium size molecules, measured by mass spectrometry, can be used to determine the composition ...
Chronic obstructive pulmonary disease
Mass spectrometry is being studied as a diagnostic tool in COPD.[198] ... Puhan MA, Gimeno-Santos E, Cates CJ, Troosters T (December 2016). "Pulmonary rehabilitation following exacerbations of chronic ... Puhan MA, Gimeno-Santos E, Cates CJ, Troosters T (December 2016). "Pulmonary rehabilitation following exacerbations of chronic ... Vollenweider DJ, Frei A, Steurer-Stey CA, Garcia-Aymerich J, Puhan MA (October 2018). "Antibiotics for exacerbations of chronic ...
Scutellaria
... lateriflora by liquid chromatography with ultraviolet photodiode array and electrospray ionization tandem mass spectrometry". ... Liu X, Hong SI, Park SJ, Dela Peña JB, Che H, Yoon SY, Kim DH, Kim JM, Cai M, Risbrough V, Geyer MA, Shin CY, Cheong JH, Park H ...
Psoralen
... and a Novel Method for their Detection by Surface-Enhanced Laser Desorption Ionization Time-of-Flight Mass Spectrometry (SELDI- ... Lu Z, Zhang QC, Lee B, Flynn RA, Smith MA, Robinson JT, Davidovich C, Gooding AR, Goodrich KJ, Mattick JS, Messirov JP, Cech TR ... Saffran WA, Ahmed A, Binyaminov O, Gonzalez C, Gupta A, Fajardo MA, Kishun D, Nandram A, Reyes K, Scalercio K, Senior CW (2014 ...
Eosinophilia-myalgia syndrome
These were characterized using accurate mass LC-MS, LC-MS/MS and multistage mass spectrometry (MSn).[16] The last of the six ... Williamson BL, Johnson KL, Tomlinson AJ, Gleich GJ, Naylor S (October 1998). "On-line HPLC-tandem mass spectrometry structural ...
AKTIP - ويكيبيديا
"Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/ ...
Chemistry
The particles that make up matter have rest mass as well - not all particles have rest mass, such as the photon. Matter can be ... some mass will be lost with it. High energy losses result in loss of weighable amounts of mass, an important topic in nuclear ... they may not necessarily have the same mass number; atoms of an element which have different mass numbers are known as isotopes ... The mass number is the sum of the number of protons and neutrons in a nucleus. Although all the nuclei of all atoms belonging ...
Pyknosis
Mass spectrometry. *Chromatography. *Flow cytometry. *Blood bank. *Microbiological culture. *Serology. .mw-parser-output .asbox ...
University of Missouri Research Reactor Center
... multiple ICP-mass spectrometers, and a multi-collector ICP-MS for isotope-ratio mass spectrometry. The laboratory is one of ...
Spectrophotometry
Inductively coupled plasma mass spectrometry. *LBOZ. *Spectroradiometry. *Slope spectroscopy. *Microspectrophotometry. ...
Chicanná
... of indigoid compounds present in archaeological Maya blue by pyrolysis-silylation-gas chromatography-mass spectrometry. Journal ...
CID
Collision-induced dissociation, a mass spectrometry mechanism. *Configuration interaction doubles, in quantum chemistry ...
Antigen
As of 2015 mass spectrometry resolution is insufficient to exclude many false positives from the pool of peptides that may be ...
The Rockefeller University »
Mass spectrometry - Wikipedia
Main article: Ion-mobility spectrometry-mass spectrometry. Ion mobility spectrometry-mass spectrometry (IMS/MS or IMMS) is a ... accelerator mass spectrometry (AMS), thermal ionization-mass spectrometry (TIMS) and spark source mass spectrometry (SSMS). ... Photoionization mass spectrometry[edit]. Photoionization can be used in experiments which seek to use mass spectrometry as a ... Preparative mass spectrometry[edit]. The primary function of mass spectrometry is as a tool for chemical analyses based on ...
Mass spectrometry imaging - Wikipedia
Mass spectrometry imaging (MSI) (also known as imaging mass spectrometry) is a technique used in mass spectrometry to visualize ... McDonnell LA, Heeren RM (2007). "Imaging mass spectrometry". Mass spectrometry reviews. 26 (4): 606-43. PMID 17471576. doi: ... Imaging Mass Spectrometry Markup Language: A Common Data Format for Mass Spectrometry Imaging in Data Mining in Proteomics: ... "Journal of the American Society for Mass Spectrometry. 24 (5): 718-721. PMC 3693088 . PMID 23536269. doi:10.1007/s13361-013- ...
UT Austin Mass Spectrometry Facility
Posted Jan 4, 2018, 9:20 AM by Mass Spec * MSF Closed 12/22/17 - 1/1/18 The Mass Spectrometry Facility will be closed from ... 2017 MS and NMR Seminar Series The UT Austin Chemistry Departments Mass Spectrometry and Nuclear Magnetic Resonance Facilities ... Posted Jun 8, 2017, 3:16 PM by Mass Spec * Mass Spec E-Mail List 5/9/17We have recently created a UT list e-mail group called ... Our facility offers support for the analysis of a wide variety of analytes using mass spectrometry based techniques. We have ...
Fees | Mass Spectrometry Center
Mass spectrometry | Britannica.com
The instruments used in such studies are called mass spectrometers and mass spectrographs, and they operate on ... Mass spectrometry, analytic technique by which chemical substances are identified by the sorting of gaseous ions in electric ... and magnetic fields according to their mass-to-charge ratios. ... Mass spectrometry. Mass spectrometry differs from the types of ... Alternative Title: mass spectroscopy. Mass spectrometry, also called mass spectroscopy, analytic technique by which chemical ...
Instrumentation | Mass Spectrometry Center
The Mass Spectrometry Center provides a suite of state-of-the-art instrumentation to UMass researchers with a broad range from ... The Mass Spectrometry Center provides a suite of state-of-the-art instrumentation to UMass researchers with a broad range from ... University of Massachusetts Amherst Search Google Appliance. Enter the terms you wish to search for. Links ...
Mass Spectrometry
... The Warwick Mass Spectrometry community includes scientists with a wide range of technical and applications ... Dr Mark Barrow (Petroleum-related and environmental samples using FT-ICR mass spectrometry) ... Dr Lijiang Song (Natural product chemistry, metabolomics, Head of Chemistry Mass Spectrometry Facility) ... Improving the performance and applications of Fourier Transform Ion Cyclotron Resonance (FTICR) mass spectrometers ...
Mass Spectrometry of Glycoproteins | SpringerLink
In Mass Spectrometry of Glycoproteins: Methods and Protocols, expert researchers in the field detail many of the methods that ... Authoritative and practical, Mass Spectrometry of Glycoproteins: Methods and Protocol is an essential resource for those who ... Case Studies in Mass Spectrometry of Glycoproteins. * Front Matter Pages 277-277 ... Stable Isotope Labeling of N-Glycosylated Peptides by Enzymatic Deglycosylation for Mass Spectrometry-Based Glycoproteomics ...
Chemical compound - Mass spectrometry | Britannica
Mass spectrometry: Mass spectrometry differs from the types of spectroscopy previously discussed because the molecular ... From the masses and abundance of the peaks in a mass spectrum, it is often possible to determine the exact mass of the molecule ... In a mass spectrometer, molecules are converted to charged fragments called ions, which are then separated according to their ... The chart that records the masses of the fragments together with a measure of their relative abundance is known as a mass ...
Mass Spectrometry Data Center | NIST
The Mass Spectrometry Data Center measures, compiles, evaluates, and correlates Standard Reference Data and develops and ... Mass Spectrometry Data Center Expand or Collapse*Mass Spectrometry Data Center Staff ... Mass Spectrometry Data Center. The Mass Spectrometry Data Center measures, compiles, evaluates, and correlates Standard ... reference tandem mass spectra of small molecules generated by electrospray and MALDI mass spectrometry widely used for ...
Mass Spectrometry Proteomics
... forms and personnel for the Mass Spectrometry-Proteomics Core Laboratory at Baylor College of Medicine.... ... The Mass Spectrometry (MS) Proteomics Core at Baylor College of Medicine offers three specialized and comprehensive project ... mass spectrometry sequencing, and data analysis performed within the core and by the experienced core personnel. The Proteomics ... isolation and identification of endogenous or tagged protein complexes via immunoprecipitation followed by mass spectrometry ...
Mass Spectrometry Facility
The mass spectrometry facility is housed in a 1000 sq ft laboratory located in the UMSL Research Building (R003). In addition ... A high-performance magnetic sector mass spectrometer for both high and low resolution mass spectral analysis equipped for:. * ... Double focusing capability provides accurate mass (+/- 1 mmu) if so desired; with appropriate calibration compounds, mass ... Analytical Facilities Microscopy X-Ray Diffraction Laboratory Molecular Modeling and Simulation High Field NMR Facility Mass ...
Mass Spectrometry | The University of Vermont
Mass Spectrometry. An in-depth treatment of modern mass spectrometry, instrumentation, and techniques with discussion of ... Mass Spectrometry Dwight Matthews Spring 2016 15168 CHEM 223 A Mass Spectrometry Dwight Matthews Spring 2012 13836 ... Mass Spectrometry Dwight Matthews Spring 2010 13340 CHEM 223 A Mass Spectrometry Dwight Matthews Fall 2007 92381 ... Mass Spectrometry Dwight Matthews Fall 2005 91280 CHEM 223 A Mass Spectrometry Dwight Matthews Fall 2003 91559 ...
Mass spectrometry of steroid systems | SpringerLink
Mass spectrometry of steroid systems. XII. Determination of the position of the double bond in some steroid systems by the ... Mass Spectrum Mass Number Androstane Sitosterol Steroid System Khimiya Prirodnykh Soerinenii, Vol. 3, No. 6, pp. 383-391, 1967 ... This permits compounds to be assigned to the Δ4 or Δ5 series on the basis of mass-spectrometric data. ...
Mass spectrometry-based proteomics. - PubMed - NCBI
Mass spectrometry-based proteomics.. Aebersold R1, Mann M.. Author information. 1. Institute for Systems Biology, 1441 North ... The ability of mass spectrometry to identify and, increasingly, to precisely quantify thousands of proteins from complex ... Recent successes illustrate the role of mass spectrometry-based proteomics as an indispensable tool for molecular and cellular ...
Mass Spectrometry Screening
We provide fully assisted Mass Spectrometry services at highly competitive rates. Our Mass Spectrometry facilities are world- ... known as bioaffinity mass spectrometry.. Our researchers have extensive expertise in applying high resolution mass spectrometry ... Dont hesitate to contact us for more information on our Mass Spectrometry screening services - please get in touch with Mass ... Our Mass spectrometry facility. The GRIDD. MS. facility is equipped with state-of-the-art instruments. These high-resolution ...
Towards single-molecule nanomechanical mass spectrometry | Nature Nanotechnology
These first nanoelectromechanical system-mass spectrometry spectra, obtained with modest mass sensitivity from only several ... some of which are unique to nanoelectromechanical system based-mass spectrometry. Mass detection of single biological molecules ... In our nanoelectromechanical-mass spectrometry system, nanoparticles and protein species are introduced by electrospray ... Here, we report the first demonstration of mass spectrometry based on single biological molecule detection with a ...
Mass Spectrometry
The Mass Spectrometry Unit performs quantitative and qualitative analysis of organic molecules using Mass spectrometry. ... Services include GC-MS analysis, LC-MS analysis, accurate mass determinations and Proteomic analysis.. The Mass Spectrometry ... Mass spectrometry (MS) with electrospray ionization (ESI) or atmospheric pressure chemical ionization (APCI) ... Tandem Mass Tag; Thermo Scientific). This method is based in the covalent attachment of an isobaric mass tag to all the samples ...
Mass Spectrometry
... including trypsin and alternative proteases specifically developed for mass spec applications. For middle-down proteomics of ... as well as peptide reference mixes and other reagents for monitoring mass spec instrument performance. ... Proteins are generally digested with proteases to generate peptides for mass spectrometry analysis (e.g., bottom-up proteomics ... Introduction to Mass Spectrometry. Mass spectrometry (MS) is a powerful analytical tool used for proteome-wide analysis and ...
Mass Spectrometry
Surface-sensitive mass spectrometry enables us to monitor the prompt (,10 μs) and simultaneous formation of primary On- ... Edited and published by : The Mass Spectrometry Society of Japan Produced and listed by : International Academic Publishing Co ... mass spectrometers have evolved to recent high-mass-resolution instruments for solar system exploration missions. ... Isotope analyses using mass spectrometers have been frequently utilized in the laboratories for the earth planetary science and ...
Open mass spectrometry search algorithm. - PubMed - NCBI
How Mass Spectrometry Works | HowStuffWorks
Mass spectrometry is an aspect of science that could finally put the steroid era of baseball to an end. Learn about mass ... Mass spectrometer: The actual device used to carry out mass spectrometry. Some mass spectrometers can sit on a tabletop. Others ... Mass Spectrometry Basics: An Atomic Balance. --The principles behind mass spectrometry are somewhat abstract, so lets start ... What is Mass Spectrometry? American Society of Mass Spectrometry. (March 3, 2009) www.asms.org/portals/0/WhatIsMSPoster.pdf ...
Mass Spectrometry Facility | LSU Chemistry
Mass Spectrometry Facility. The Louisiana State University Mass Spectrometry Facility provides analytical support for the ... Mass Spectrometry talk from Dr. Touradj Solouiki - Baylor University. Thermo Scientific Q-Exactive. Chemistry Facilities. NMR ... other events pertinent to mass spectrometry *About Us: information about the facility, its managers, locations, mailing address ...
Mass Spectrometry | Life Science Webinars
Mass spectrometry imaging produces highly complex data that is difficult to access and understand. This webinar demonstrates ... Label-Free High-Throughput MALDI TOF Mass Spectrometry in Drug Discovery The presentation will give a current overview of label ... It will explain the basics of MALDI TOF mass spectrometry and the benefits of label-free screening compared to current labeled ... The webinar provides a detailed overview of how high-resolution mass spectrometry and data acquisition using a catch all ...
Clinical Mass Spectrometry Lab | Pathology
Our Clinical Mass Spectrometry (CMS) lab supports physicians and researchers within our medical campus and beyond. Learn more ... Clinical Mass Spectrometry (CMS) Laboratory The Clinical Mass Spectrometry (CMS) facility in the Division of Pathology and ... Mass Spectrometry (CMS) Tests Available Search for different tests available through the Mass Spectrometry (CMS) Laboratory. ... The Clinical Mass Spectrometry (CMS) Laboratory of the Division of Pathology and Laboratory Medicine is located on the main ...
Mass Spectrometry : Waters
Mass spectrometry instrumentation from Waters enables you to separate compounds by mass, charge, shape, and size. These world- ... Mass Spectrometry for Quantitation Quantitative mass spectrometry in an analytical process that answers the important question ... Mass Spectrometry Waters mass spectrometers provide you with the tools to confidently identify and quantify unknown compounds ... Time-of-flight Mass Spectrometry Waters Time-of-flight MS systems, featuring QuanTof and MSE technologies, provide the highest ...
Mass Spectrometry | Curriki
The functional parts of a mass spectrometer are detailed including the ionizer, mass analyzer and the detector. A simulation of ... Mass Spectrometry,/p,,p,In this video Paul Andersen explains how a spectrometer was used to identify the presence of isotopes. ... Chlorine isotopes along with an average atomic mass calculation is included.,/p, ... 009 - Mass Spectrometry. In this video Paul Andersen explains how a spectrometer was used to identify the presence of isotopes ...
CASSS Mass Spectrometry
Mass Spectrometry in Environmental Sciences | O. Hutzinger | Springer
During the past ten years a variety of methods involving mass spectrom- etry have been developed for the analysis of ... Mass Spectrometry in Environmental Sciences. Editors: Hutzinger, O., Karasek, F.W., Safe, S. (Eds.) ... During the past ten years a variety of methods involving mass spectrom- etry have been developed for the analysis of ... Mass Spectrometry of Carbamates, Thiocarbamates, Dithiocarbamates, Urea, Thiourea, and Carboxanilide Pesticides. Onuska, ...
SpectrometerProteomicsHigh-resolution mass spectrometrySecondary ion mass speSpectrometersInstrumentationClinical Mass Spectrometry2018FacilitySpectraCharacterizationAmerican Society forInductively Coupled PlasImaging Mass SpectrometryTandemMolecularMobility spectrometrySearchAssisted Mass Spectrometry servicesQuantitativeProteinsRole of Mass SpectrometryFragmentationPrinciplesPeptidesFaces of Mass SpectrometryField of mass spectrometryAnalysisIonsSpectroscopyChemistryMixturesTriple QuadrupoleAnalytical techniqueMoleculesProteinThermo ScientificMetabolomicsIsotopeIonizationLaboratoryMethodsAnalyzerAnalytesMALDI TOFDetectorMoleculeUniversity of MassIsotopesSensitivityCompoundsResearchersBrukerQuadrupole massDetectionSpectrometricSeparationApplications
Spectrometer50
- Schematics of a simple mass spectrometer with sector type mass analyzer. (wikipedia.org)
- Thus he may be credited with the construction of the first mass spectrograph and the first mass spectrometer. (britannica.com)
- Today chemists can use one of several different types of mass spectrometer. (britannica.com)
- In simple terms, a mass spectrometer (all components of which operate in a high vacuum ) consists of an inlet chamber into which the compound to be analyzed is introduced and vaporized. (britannica.com)
- A matrix-assisted laser desorption (MALDI) time of flight (TOF) mass spectrometer. (umsl.edu)
- The complexity of total proteome demands long gradients and preferably the use of an advanced mass spectrometer such as the Thermo Scientific fusion. (sun.ac.za)
- For purified samples such as a single protein band from an SDS-PAGE gel, a 35 min gradient on the Velos mass spectrometer is sufficient. (sun.ac.za)
- NASA's mass spectrometer sits aboard a DC-8 jet to be used as a flying lab that will study the impact of air pollution on the Arctic area. (howstuffworks.com)
- The instrument is an analytical tool known as a mass spectrometer . (howstuffworks.com)
- In 1919, Francis Aston improved on Thomson's methods and apparatus, leading to the first mass spectrometer -- a machine that literally weighs atoms and molecules. (howstuffworks.com)
- Today, chemists still use the mass spectrometer to measure the molecular weights of elements, isotopes and compounds. (howstuffworks.com)
- Next, we'll take a closer look at what's going on inside a mass spectrometer. (howstuffworks.com)
- 009 - Mass SpectrometryIn this video Paul Andersen explains how a spectrometer was used to identify the presence of isotopes. (curriki.org)
- The functional parts of a mass spectrometer are detailed including the ionizer, mass analyzer and the detector. (curriki.org)
- Any sample that you study with a mass spectrometer has many boron atoms in it. (physicsforums.com)
- The Orbitrap Elite is a high performance hybrid mass spectrometer combining the high-field Orbitrap mass analyzer with the latest dual pressure linear ion trap, allowing increased speed, sensitivity and dynamic range. (edu.au)
- The TSQ Vantage is a triple quadrupole mass spectrometer. (edu.au)
- The LC-IRMS facility consists of an Accela autosampler and Accela 600 pump attached to a Delta V plus isotope ratio mass spectrometer via an LC-Isolink. (edu.au)
- The Ultraflex III is a Matrix Assisted Laser Desorption / Ionization time-of-flight mass spectrometer (MALDI-TOF/TOF) that provides the high resolution and mass accuracy required for analysis of a wide range of biomolecules. (edu.au)
- This ionized sample is then sent through a series of powerful magnets called a mass spectrometer, which separates sample ions on the basis of their mass/charge ratio. (fieldmuseum.org)
- The output of a mass spectrometer. (howstuffworks.com)
- Main steps of measuring with a mass spectrometer. (newworldencyclopedia.org)
- The ratio of charge to mass of the particles is calculated by passing them through electric and magnetic fields in an instrument called a mass spectrometer. (newworldencyclopedia.org)
- The following example describes the operation of a spectrometer mass analyzer, which is of the sector type. (newworldencyclopedia.org)
- Scientists at ETH Zurich have set a world record in mass spectrometry by observing the largest ever mass-to-charge ratio of over 1 Mio Dalton (MDa) using a special mass spectrometer. (innovations-report.com)
- For mass separation, they used a time-of-flight mass spectrometer, which separates ions of different mass-to-charge ratio by their drift time through an evacuated fligh tube. (innovations-report.com)
- Particulate samples have been introduced into a mass spectrometer ion source with a direct insertion probe thus dispensing with the extraction processes typically used in chemical characterization. (sae.org)
- Agilent Inductively Coupled Plasma Mass Spectrometer (ICP-MS) with laser ablation capability. (edu.au)
- Calibrate LTQ mass spectrometer instruments using a mixture of highly purified ionizable molecules designed for negative mode calibration. (fishersci.com)
- The Benchtop Mass Spectrometer is a compact versatile gas analysis system for sampling gases over a wide range of pressures, from high vacuum up to and beyond atmospheric pressure. (environmental-expert.com)
- Identify, quantify and confirm more compounds rapidly and with confidence using the Thermo Scientific Q Exactive Hybrid Quadrupole-Orbitrap Mass Spectrometer. (environmental-expert.com)
- The Hiden HPR-20 R&D specialist gas analysis system is a bench-top mass spectrometer for the monitoring of evolved gases and vapours. (environmental-expert.com)
- An extensive range of MS inlets for optimised coupling the HPR-20 EGA mass spectrometer to TGA systems is available. (environmental-expert.com)
- Inductively Coupled Plasma Mass Spectrometer (ICPMS) is a very versatile analytical instrument capable of trace and ultra-trace analysis and isotope ratio analysis in aqueous samples. (environmental-expert.com)
- Ambient ionisation is a form of ionization in which ions are formed outside the mass spectrometer without sample preparation or separation. (gre.ac.uk)
- Gas chromatography mass spectrometry (GC-MS) is an instrumental technique, comprising a gas chromatograph (GC) coupled to a mass spectrometer (MS), by which complex mixtures of chemicals may be separated, identified and quantified. (gre.ac.uk)
- A triple quadruple mass spectrometer is a tandem mass spectrometer consisting of two quadruple mass spectrometers in series, with a (non mass-resolving) radio frequency (RF) only quadruple between them to act as a collision cell for collision-induced dissociation. (gre.ac.uk)
- Compact process gas monitor using quadrupole mass spectrometer. (horiba.com)
- The methods involve differing ratios of hydrolyzing agent to polymer disposed upon a reaction surface adapted for use with a mass spectrometer. (google.com)
- The apparatus involves a mass spectrometer sample holder, having hydrolyzing agent disposed thereon, which is useful for adapting any mass spectrometer for polymer sequencing. (google.com)
- 20. The method of claim 1 wherein said reaction surface comprises a mass spectrometer sample holder having microreaction vessels disposed thereon. (google.com)
- 4. The apparatus of claim 3 wherein the analytical apparatus comprises a mass spectrometer. (google.com)
- The Synapt G2S mass spectrometer is equipped with a versatile ion source front, allowing to connect several ionization sources. (wur.nl)
- The ions are sampled and analyzed by the mass spectrometer after interaction with the ESI plume. (wur.nl)
- A HewlettPackard 5890 Series II gas chromatograph with flame ionization detector (FID) coupled to 5972 MSD quadrupole mass spectrometer was used. (scribd.com)
- See how utilizing a modern mass spectrometer can determine amino acid sequences and sequential fragmentation. (criver.com)
- Proteomics, or protein identification, employs tandem mass spectrometry (MS/MS) of proteolytically generated peptides from a biological sample using a high-resolution mass spectrometer ( e.g., the Orbitrap Fusion) coupled with liquid chromatography. (criver.com)
- This instrument combines an ion trap mass spectrometer with collision induced dissociation (CID), higher-energy collisional dissociation (HCD) and electron transfer dissociation (ETD) fragmentation techniques to produce a high resolution instrument with high mass accuracy. (carolinashealthcare.org)
- Secondary ions are collected and focused into a reflectron time-of-flight (TOF) mass spectrometer. (nrel.gov)
- A mass spectrometer consists of three components: an ion source, a mass analyzer, and a detector. (wikipedia.org)
Proteomics11
- Recent successes illustrate the role of mass spectrometry-based proteomics as an indispensable tool for molecular and cellular biology and for the emerging field of systems biology. (nih.gov)
- Aebersold, R. & Mann, M. Mass spectrometry-based proteomics. (nature.com)
- The Proteomics facility is equipped with two state of the art mass spectrometers a LTQ Orbitrap Velos and a Fusion which were both the first of their kind in South Africa. (sun.ac.za)
- Applications of proteomics to cell biology and biomedical research require further developments of mass spectrometry (MS) technology to overcome long-standing limitations in speed, sensitivity and robustness. (news-medical.net)
- It summarizes breakthroughs in the theory and instrumentation of electrospray mass spectrometry in pharmaceutical and biomedical applications, provides practical examples for the characterization of peptides, proteins, and glycoproteins, includes applications in proteomics, combinatorial chemistry, and drug characterization. (routledge.com)
- The other factors that are driving the growth of the global market include the increasing use of mass spectrometry in proteomics and the increasing usage amongst emerging nations. (pitchengine.com)
- We provide proteomics and mass spectrometry services for UK based researchers, engage in research collaborations and implement current technologies in facility services. (keele.ac.uk)
- How are proteomics services performed using mass spectrometry services? (criver.com)
- The Mass Spectrometry and Proteomics Core Facility is located in the Cannon Research Center at Carolinas Medical Center. (carolinashealthcare.org)
- The Mass Spectrometry and Proteomics Core Facility uses high-throughput nano flow liquid-chromatography tandem mass spectrometry to identify proteins from one dimensional or two dimensional polyacrylamide gel slices. (carolinashealthcare.org)
- Computational methods for mass spectrometry proteomics. (wikipedia.org)
High-resolution mass spectrometry7
- In high-resolution mass spectrometry, the mass of the molecular ion can be measured to an accuracy of 4 ppm. (britannica.com)
- In such an instrument, the molecular ion of 2-butanone would appear at m / z = 72.0575, which would unambiguously establish its molecular formula as C 4 H 8 O. High-resolution mass spectrometry is an excellent method for determining the molecular formulas of organic compounds . (britannica.com)
- Our researchers have extensive expertise in applying high resolution mass spectrometry to identify new binding ligands to target proteins for drug discovery. (edu.au)
- The webinar provides a detailed overview of how high-resolution mass spectrometry and data acquisition using a 'catch all compound' acquisition scan mode can reduce instances of reporting false positives and negatives. (news-medical.net)
- Un)targeted Ambient Scanning of Locks of Hair for Drugs of Abuse using Direct Analysis in Real Time - High Resolution Mass Spectrometry. (wur.nl)
- Our large molecule GMP mass spectrometry facility offers a wide variety of protein, peptide, glycoprotein, glycoconjugate, proteomic, and specialty analytical services employing Orbitrap Fusion (CID/HCD/ETD) and QTOF high resolution mass spectrometry platforms. (criver.com)
- This use is also implied by the term "high-resolution mass spectrometry. (wikipedia.org)
Secondary ion mass spe2
- [1] Emerging technologies in the field of MSI are MALDI imaging and secondary ion mass spectrometry imaging ( SIMS imaging ). (wikipedia.org)
- Secondary ion mass spectrometry (SIMS) is used to analyze solid surfaces and thin films by sputtering the surface with a focused primary ion beam and collecting and analyzing ejected secondary ions. (wikipedia.org)
Spectrometers23
- Calutron mass spectrometers were used in the Manhattan Project for uranium enrichment. (wikipedia.org)
- Sector mass spectrometers known as calutrons were developed by Ernest O. Lawrence and used for separating the isotopes of uranium during the Manhattan Project . (wikipedia.org)
- [9] Calutron mass spectrometers were used for uranium enrichment at the Oak Ridge, Tennessee Y-12 plant established during World War II. (wikipedia.org)
- The instruments used in such studies are called mass spectrometers and mass spectrographs , and they operate on the principle that moving ions may be deflected by electric and magnetic fields. (britannica.com)
- In addition to the three mass spectrometers described below, there are areas for data processing, instrument maintenance, parts storage and sample preparation. (umsl.edu)
- These sophisticated mass spectrometers provide South African researchers the unique opportunity to analyse thousands of proteins in one run. (sun.ac.za)
- The much reduced complexity of purified samples allow the use of shorter gradient times and does not require the use advanced mass spectrometers. (sun.ac.za)
- Isotope analyses using mass spectrometers have been frequently utilized in the laboratories for the earth planetary science and other scientific and industrial fields. (go.jp)
- In order to conduct in-situ measurements of compositions and isotope ratios around planets and moons, mass spectrometers onboard spacecraft have also been developed. (go.jp)
- Ion and electron instruments on orbiters have provided much outputs for the space and planetary science since the early days and mass spectrometers on landers and rovers have recently performed isotope analyses on planetary bodies. (go.jp)
- We review spaceborne mass spectrometers, instrumentations, and observation results. (go.jp)
- Starting with spaceborne ion instruments to measure three distribution functions as well as mass for the space plasma physics, mass spectrometers have evolved to recent high-mass-resolution instruments for solar system exploration missions. (go.jp)
- Waters mass spectrometers provide you with the tools to confidently identify and quantify unknown compounds in complex samples, and confirm trace components at the lowest possible levels. (waters.com)
- H Wollnik, Ion optics in mass spectrometers. (uvm.edu)
- Some mass spectrometers can sit on a tabletop. (howstuffworks.com)
- The range of mass spectrometers has grown to the point where the group now has a wide range of state-of-the-art systems capable of dealing with all sample types and a wide array of client demands. (southampton.ac.uk)
- The mass spectrometers are available for self use by graduate students and post-docs after training by MS Facility staff. (edu.au)
- The facility also houses high-end mass spectrometers, including single quadrupole, triple quadrupole, high resolution, MALDI and time of flight instruments. (edu.au)
- Calibrate LTQ Velos, LTQ Orbitrap and other mass spectrometers using a mixture of highly purified ionizable molecules designed for positive mode calibration. (fishersci.com)
- Calibrate LTQ, LTQ Orbitrap, LXQ and LCQ FLEET mass spectrometers using a mixture of highly purified ionizable molecules designed for positive mode calibration. (fishersci.com)
- Calibrate Triple Stage Quadrupole (TSQ) mass spectrometers using a mixture of high purity, ionizable components specifically designed for positive mode calibration. (fishersci.com)
- Various orbitrap instruments, including the commercially available linear ion trap-orbitrap hybrid mass spectrometers, are also discussed with emphasis on the different methods used to inject ions into the trap. (psu.edu)
- Keele has invested in a variety of mass spectrometers with complementary analytical capabilities, together with HPLC equipment to provide upstream separation for enhanced sensitivity and automation. (keele.ac.uk)
Instrumentation8
- The Mass Spectrometry Center provides a suite of state-of-the-art instrumentation to UMass researchers with a broad range from applications, from biologically-derived samples through small molecules and synthetic polymers. (umass.edu)
- An in-depth treatment of modern mass spectrometry, instrumentation, and techniques with discussion of biological and chemical applications. (uvm.edu)
- This application claims the benefit of U.S. Provisional Application No. 61/146,243, entitled "DOWNHOLE MASS SPECTROMETRY INSTRUMENTATION," filed Jan. 21, 2009, the entire disclosure of which is hereby incorporated herein by reference. (freepatentsonline.com)
- summarizes the most recent breakthroughs in the theory and instrumentation of electrospray mass spectrometry. (routledge.com)
- Intertek Whitehouse offers advanced capabilities in the field of mass spectrometry using instrumentation able to support both regulated and non-regulated activities including pharmaceutical, food, cosmetic and chemical applications. (intertek.com)
- It is the first book to systemically cover the theoretical background, techniques, instrumentation, and practical applications of planar chromatography-mass spectrometry as a hyphenated tool of analytical chemistry. (routledge.com)
- Our experience managing complex mass spectrometry projects combined with our state-of-the-art instrumentation and infrastructure allows us to deliver high quality GMP structural characterization and proteomic analytical services. (criver.com)
- The current mass spectrometry instrumentation includes an LTQ-XL and a TSQ Quantum Ultra, both with acquity UPLC systems, and an LTQ-XL Orbitrap-ETD with nano acquity UPLC. (carolinashealthcare.org)
Clinical Mass Spectrometry5
- The Clinical Mass Spectrometry (CMS) facility in the Division of Pathology and Laboratory Medicine provides a wide range of assays for endogenous compounds and metabolites, natural and medicinal products, novel drugs under development, therapeutic drug monitoring, detection of drugs of abuse (including opioids), comprehensive lipidomics / metabolomics analyses, and diagnoses of genetic disorders in metabolism. (cincinnatichildrens.org)
- The Clinical Mass Spectrometry (CMS) Laboratory of the Division of Pathology and Laboratory Medicine is located on the main campus of Cincinnati Children's Hospital, in Research Building Location R, rooms R025 - R034. (cincinnatichildrens.org)
- Clinical mass spectrometry plays a vital role in the drug discovery pipeline for the development of personalized medicines. (openpr.com)
- The Global Clinical Mass Spectrometry Market analysis report covers detailed value chain analysis of Global Clinical Mass Spectrometry Market. (openpr.com)
- The Global Clinical Mass Spectrometry Market report explores manufacturer's competitive scenario and provides market share for all major players of this market based on production capacity, sales, revenue, geographical presence and other major factors. (openpr.com)
20181
- The report "Mass Spectrometry Market - by Technology (Tandem LC-MS/Quadrupole/ICP-MS/Gas Chromatography - MS/TOF-MS/MALDI-TOF/Fourier Transform-MS) & by Application (Pharmaceutical/Biotechnology/Environment/Food & Beverages) - Global Trends & Forecast to 2018" , this report studies the global mass spectrometry market over the forecast period of 2013 to 2018. (pitchengine.com)
Facility14
- The mass spectrometry facility has finished moving to NHB! (google.com)
- Our Mass Spectrometry Facility runs over 20,000 samples every year! (google.com)
- Our facility offers support for the analysis of a wide variety of analytes using mass spectrometry based techniques. (google.com)
- MSF Closed 12/22/17 - 1/1/18 The Mass Spectrometry Facility will be closed from December 22nd to January 1st. (google.com)
- The mass spectrometry facility is housed in a 1000 sq ft laboratory located in the UMSL Research Building (R003). (umsl.edu)
- Don't hesitate to contact us for more information on our Mass Spectrometry screening services - please get in touch with Mass Spectrometry Facility Manager Dr Wendy Loa or GRIDD Strategic Development Manager Dr Raya Monteiro with your inquiry. (edu.au)
- The Louisiana State University Mass Spectrometry Facility provides analytical support for the Chemistry Department and other academic departments at LSU, researchers at other universities, and customers from private industry. (lsu.edu)
- The Mass Spectrometry Facility provides mass spectrometry analysis to researchers, and assists in the development and analysis of mass spectrometry experiments. (uoguelph.ca)
- The Mass Spectrometry Facility is able to do a variety of analyses, please contact Dr. Dyanne Brewer for further details. (uoguelph.ca)
- This state of the art facility, situated within the La Trobe Institute for Molecular Science (LIMS) offers a comprehensive range of different types of mass spectrometry equipment. (edu.au)
- The following mass spectrometry instruments are available at the Whitehouse facility. (intertek.com)
- The department's Mass Spectrometry Facility currently has 3 instruments, consisting of an LC-MS system and two GC-MS systems. (edu.au)
- The Separation Science and Mass Spectrometry Facility houses a range of modern chromatography and mass spectrometry equipment which support research and teaching in analytical chemistry at RMIT. (edu.au)
- The Mass Spectrometry Facility at Keele University is run in collaboration with Guy Hilton Research Centre (GHRC) and the Robert Jones and Agnes Hunt Orthopaedic Hospital (RJAH) in Oswestry. (keele.ac.uk)
Spectra14
- Results are displayed as spectra of the signal intensity of detected ions as a function of the mass-to-charge ratio. (wikipedia.org)
- the primary ion beam is emitted across the sample while secondary mass spectra are recorded. (wikipedia.org)
- However, if the analyte being tested has a low mass value then it can produce a similar looking spectra to that of a MALDI spectra. (wikipedia.org)
- Mass spectra of literally hundreds of compounds, among them complex carbohydrates, a variety of organometallics, synthetic polyamides as well as complex alkaloids and other natural products, have been obtained using one of the afore mentioned ionization methods. (umsl.edu)
- These first nanoelectromechanical system-mass spectrometry spectra, obtained with modest mass sensitivity from only several hundred mass adsorption events, presage the future capabilities of this approach. (nature.com)
- In the Open Mass Spectrometry Search Algorithm (OMSSA), specificity is calculated by a classic probability score using an explicit model for matching experimental spectra to sequences. (nih.gov)
- With technologies like QuanTof (for a new dimension in high-resolution exact mass MS), StepWave (for confirmation of trace components), Triwave (for characterization of complex mixtures), and MS E (for exact-mass ion spectra from your samples), your possibilities are endless. (waters.com)
- In this way, simple and directly interpretable mass spectra were obtained from immunoglobuline M (ca. 1 MDa) and from von Willebrand factor, a group of proteins that play an important role in coagulation of blood (signals at 0.5, 1, 1.5 and 2 MDa). (innovations-report.com)
- Typical mass spectra are presented for each operating condition. (sae.org)
- The Ambient Mass Spectrometry Imaging system can image sample surfaces under ambient native conditions, without sample preparation, and generate accurate localized mass spectra. (wur.nl)
- After tissue sectioning and transfer onto a conductive and transparent sample plate, the MALDI matrix is deposited, and data are acquired by recording mass spectra according to a raster of points covering the surface to be analyzed. (mcponline.org)
- Mass spectra recorded with their coordinates on the tissue are processed, and molecular images of the localization of molecules can be reconstructed. (mcponline.org)
- We offer a range of the most commonly used Mass Spectrometry standards needed for standardizing your mass spectra. (alfa.com)
- Interpretation of mass spectra. (wikipedia.org)
Characterization7
- Inductively Coupled Plasma-Mass Spectrometry (ICP) is a powerful technique of chemical characterization capable of simultaneously measuring up to 50 different trace elements, sometimes at concentrations as low as several parts per billion. (fieldmuseum.org)
- With a proven track record of success in the biopharmaceutical industry, it analyzes mass spectrometry data for a variety of tasks related to protein characterization, such as identification and quantification of Post Translational Modifications (PTMs). (prweb.com)
- Mass spectrometry (MS) offers unmatched capabilities for the detection, characterization, and identification of a broad range of analytes. (springer.com)
- C. Cremers and D. Bayer, "Differential electrochemical mass spectrometry (DEMS) technique for direct alcohol fuel cell characterization," in Polymer Electrolyte Membrane and Direct Methanol Fuel Cell Technology , C. Hartnig and C. Roth, Eds. (hindawi.com)
- Intertek Allentown has many years of experience in developing liquid chromatography mass spectrometry (LCMS) applications for solving a variety of characterization needs and problem resolution. (intertek.com)
- Ambient Characterization of Synthetic Fibers by Laser Ablation Electrospray Ionization Mass Spectrometry. (wur.nl)
- With over 20 years of experience in mass spectrometry services, we have a proven track record supporting diverse protein characterization programs including large molecule comparability studies. (criver.com)
American Society for1
- P Price: Standard definitions of terms relating to mass spectrometry: A report from the Committee on Measurements and Standards of the American Society for Mass Spectrometry. (uvm.edu)
Inductively Coupled Plas3
- Our Inductively Coupled Plasma Mass Spectrometry (ICP-MS) Laboratory operates around a new Thermo ICAP Q quadrupole ICP-MS and a New Wave UP213 laser ablation system for solid sample introduction. (fieldmuseum.org)
- The Teledyne CETAC Aridus3 Desolvating Nebulizer System is a specialized liquid sample introduction accessory for inductively coupled plasma mass spectrometry (ICPâ€'MS). The Aridus3 can enhance analyte sensitivity up to 10 times or more and can greatly reduce solvent-based interferences such as oxides and hydrides. (environmental-expert.com)
- Inductively Coupled Plasma Mass Spectrometry (ICP-MS) features microscale(10-6(, trace(10-9(, and ultratrace(10-12( element analysis techniques. (environmental-expert.com)
Imaging Mass Spectrometry2
- Mass spectrometry imaging (MSI) (also known as imaging mass spectrometry) is a technique used in mass spectrometry to visualize the spatial distribution of chemical compositions e.g. compounds, biomarkers , metabolites , peptides or proteins by their molecular masses. (wikipedia.org)
- Imaging Mass Spectrometry: An Overview presented by Michelle L. Reyzer (Vanderbilt University) and Demian R. Ifa (York University) on November 8, 2013. (asms.org)
Tandem7
- Tandem Quadrupole ( Triple Quadrupole ) Mass Spectrometry Waters innovative tandem quadrupole MS technology is designed for quantitative UPLC®-MS/MS. Our philosophy centers on making high performance accessible, robust and reliable. (waters.com)
- Increasingly, tandem mass spectrometry (MS/MS) is being used for newborn screening because this laboratory testing technology substantially increases the number of metabolic disorders that can be detected from dried blood-spot specimens. (cdc.gov)
- The introduction of tandem mass spectrometry (MS/MS) in the 1990s for population-based newborn screening has enabled health-care providers to detect an increased number of metabolic disorders in a single process by using dried blood-spot specimens routinely collected from newborns ( 13 ). (cdc.gov)
- Application of tandem mass spectrometry for species identification is illustrated. (sae.org)
- A liquid chromatography-tandem mass spectrometry multiresidue method for quantification of specific metabolites of organophosphorous pesticides, synthetic pyrethroids, selected herbicides, and DEET in human urine. (thefreedictionary.com)
- Tandem Mass Spectrometry or MS/MS presented by Scott A. McLuckey (Purdue University) on June 14, 2014. (asms.org)
- Resulting peptides are extracted from the gel matrix and analyzed using reversed phase nano-litter flow liquid chromatography followed by tandem mass spectrometry. (carolinashealthcare.org)
Molecular22
- With our three staff operated instruments, we provide services for molecular formula confirmation (accurate mass measurement), structural elucidation (MS/MS) and quantitation of small molecules. (google.com)
- Mass spectrometry differs from the types of spectroscopy previously discussed because the molecular information that the technique provides does not depend on absorption of electromagnetic radiation. (britannica.com)
- From the masses and abundance of the peaks in a mass spectrum, it is often possible to determine the exact mass of the molecule being analyzed and to obtain clues about molecular structure. (britannica.com)
- Mass spectrometry can be used to analyze the molecular structure of organic compounds such as 2-butanone. (britannica.com)
- The mass analyzer contains a strong magnetic field , through which the molecular ions must pass. (britannica.com)
- The peak at m / z = 72 is the molecular ion and as such gives the molecular mass of the molecule. (britannica.com)
- Valuable information about molecular structure also can be obtained from the mass of the fragments present in the mass spectrum. (britannica.com)
- High-Mass option facilities, easier characterisation of high-molecular weight species and native state protein complexes. (edu.au)
- GRIDD provides high-resolution mass measurement to determine the molecular formula of chemical entities as a service for Griffith researchers and external organisations. (edu.au)
- Nanoelectromechanical systems provide unparalleled mass sensitivity, which is now sufficient for the detection of individual molecular species in real time. (nature.com)
- Mass Spectrometry Imaging Bringing together the powerful technologies of MALDI and DESI to discover, identify, and measure a broad range of molecular targets, delivering multi-layered, information-rich data from a single sample. (waters.com)
- Due to its structurally significant mass spectral peaks, extended range of analyzable low volatility samples, enhanced molecular ions, and valuable isotope ratio information, GC-MS is a powerful tool for geochemical applications. (news-medical.net)
- Identify unknown components by screening their accurate mass and/or predicted molecular formula against the local PubChem database. (acdlabs.com)
- In this issue of Clinical Chemistry, Muddiman and coworkers from the Mayo Clinic present reports in which two levels of mass spectrometry experiments are used to detect and characterize transthyretin variants by accurately measuring the molecular mass of the intact protein isolated from human serum (1, 2). (thefreedictionary.com)
- It covers electrophoretic-mass spectrometry methods and applications, which are considered planar chromatographic techniques and are increasingly being exploited in proteomic and molecular biology studies as well as for medical diagnostic purposes. (routledge.com)
- We used ESI-MS =-=(17)-=- to measure the potential zinc ion binding of SAG by comparing the molecular mass of SAG under denaturing and nondenaturing solution conditions (37, 72). (psu.edu)
- We are using the ESI-MS modification preferentially for proteins and peptides of low molecular mass th. (psu.edu)
- Ten years' evolution from one of the first MALDI images presented in 1999 at the 47th ASMS Conference on Mass Spectrometry and Allied Topics ( left ) (reprinted with permission of Caprioli and co-workers (84)) and molecular images obtained by our group for mouse stem cells injected in brain tissue sections ( right ) (M. Wisztorski, C. Meriaux, M. Salzet, and I. Fournier, unpublished results). (mcponline.org)
- Mass species representing molecular features of preinvasive and invasive lesions of the breast. (mcponline.org)
- Molecular weight, or molecular mass, is the total mass of a molecule based on the atomic masses of its individual atoms. (criver.com)
- By providing mass determination with low measurement errors (parts per million, ppm), mass spectrometry enables precise determination of molecular composition. (criver.com)
- Performs mass analysis to determine the elemental or molecular composition (or both) of the top monolayer of a material's surface. (nrel.gov)
Mobility spectrometry4
- Our research focuses on the development and application of mass spectrometry and ion mobility spectrometry techniques to elucidate the structures and assembly of protein complexes and subcellular machines. (washington.edu)
- Ion mobility spectrometry (IMS-MS) is an analytical technique used to separate and identify ions in the gas phase based on their ion mobility in a buffer gas and detect via a mass detector. (gre.ac.uk)
- High resolution indicating better peak separation is also used in ion mobility spectrometry. (wikipedia.org)
- Ion mobility spectrometry. (wikipedia.org)
Search2
- Open mass spectrometry search algorithm. (nih.gov)
- Search for different tests available through the Mass Spectrometry (CMS) Laboratory. (cincinnatichildrens.org)
Assisted Mass Spectrometry services1
- We provide fully assisted Mass Spectrometry services at highly competitive rates. (edu.au)
Quantitative6
- Mass spectrometry provides rapid and quantitative identification of protein species with relatively low sample consumption. (nature.com)
- The Mass Spectrometry Unit performs quantitative and qualitative analysis of organic molecules using Mass spectrometry. (sun.ac.za)
- Time-of-flight Mass Spectrometry Waters Time-of-flight MS systems, featuring QuanTof and MS E technologies, provide the highest UPLC-MS performance to meet the needs of challenging qualitative and quantitative applications. (waters.com)
- Mass Spectrometry for Quantitation Quantitative mass spectrometry in an analytical process that answers the important question of 'How much is in my sample? (waters.com)
- The workshop brought together researchers, practitioners and laboratory managers from industry, academia, and government to present new results, discuss recent trends, and identify important problems in the area of quantitative mass spectrometry of synthetic polymers. (thefreedictionary.com)
- Quantitative synthetic polymer mass spectrometry workshop. (thefreedictionary.com)
Proteins10
- We develop proteomic tools for dissecting cellular function, with a special emphasis on the mass spectrometry (MS) of peptides and proteins. (rockefeller.edu)
- The ability of mass spectrometry to identify and, increasingly, to precisely quantify thousands of proteins from complex samples can be expected to impact broadly on biology and medicine. (nih.gov)
- These high-resolution electrospray ionisation mass spectrometry instruments support a range of research projects focused on the study of proteins and complexes of protein with fragments, compounds and natural product extracts, known as bioaffinity mass spectrometry. (edu.au)
- Capture, concentrate and desalt 10 to 100 microliter samples of peptides and proteins for MALDI mass spectrometry with these ready-to-use pipette-tip columns of C18 resin. (fishersci.com)
- It is also useful for analysis of high mass species that form multiply charged ions with ESI (such as proteins, peptides) due to the post-acquisition de-convolution capability of the operating software. (gre.ac.uk)
- Mass-spectrometry based Reference Methods, well established for small molecules as glucose, cholesterol or steroid hormones, have not been available, until recently, for quantification of proteins. (ptb.de)
- One present study is about mass spectrometric quantification of viral proteins. (ptb.de)
- It is spectrometry based on the mass or weight of the proteins. (myeloma.org)
- Based on the weight of monoclonal proteins, e.g. lambda or kappa, their mass can be distinguished in a very specific way - in a number of daltons, which is the expression of the weight. (myeloma.org)
- The Mass Spectrometry Shared Resource provides services to elucidate the primary structure of novel proteins and to analyze protein/protein interactions, post-translational modifications and protein levels. (cshl.edu)
Role of Mass Spectrometry1
- The Expanding Role of Mass Spectrometry in Biotechnology, Second Edition. (wikipedia.org)
Fragmentation1
- Predict mass fragmentation in seconds with ACD/MS Fragmenter. (acdlabs.com)
Principles6
- A brief description of electron-ionization mass spectrometry, widely used for the analysis of relatively small molecules, illustrates the general principles. (britannica.com)
- The principles behind mass spectrometry are somewhat abstract, so let's start with a concrete mental exercise. (howstuffworks.com)
- Contributors from pharmaceuticals, biochemistry, and other biomedical disciplines review and illustrate the principles and applications of using mass spectrometry to study biomolecular interactions. (thefreedictionary.com)
- Mass spectrometry imaging (MSI) integrates MS data with information on the spatial distributions of the analytes, further enhancing the applicability of MS. In Mass Spectrometry Imaging: Principles and Protocols, expert practitioners from academia, industry, and the clinic contribute cutting-edge protocols describing the application of MSI to investigations of analyte localization in a variety of specimens, from microorganisms to plant and animal tissues. (springer.com)
- Comprehensive and up-to-date, Mass Spectrometry Imaging: Principles and Protocols is written for scientists, biological and chemical engineers, and clinicians who are interested in applying MSI in their work and those who would benefit from having detailed experimental guidelines available in a single, convenient source. (springer.com)
- Mass spectrometry: principles and applications. (wikipedia.org)
Peptides4
- 15 synthetic heavy peptides mixed in equimolar ratio to test and calibrate reverse-phase liquid chromatography (LC) and mass spectrometry (LC-MS) equipment. (fishersci.com)
- Peptide mapping is used to confirm protein primary structure by determining its amino acid sequence and employing endoproteases (enzymes) to generate peptides, followed by analysis by HPLC coupled with mass spectrometry. (criver.com)
- In this study, multidimensional separations were coupled with mass spectrometry to detect and sequence mixtures of model proto-peptides. (pnas.org)
- Whereas the majority of studies in the field focus on peptides containing only one or two types of amino acids, here we used modern mass spectrometry (MS)-based techniques to separate and sequence de novo proto-peptides containing broader combinations of prebiotically plausible monomers. (pnas.org)
Faces of Mass Spectrometry4
- As an initiative of the ASMS Diversity Committee, JASMS editors are pleased to share the "Faces of Mass Spectrometry" interview series. (asms.org)
- We welcome nominations (and self-nominations) of members to profile in the Faces of Mass Spectrometry. (asms.org)
- As part of the nomination we request a 300 word (max) statement to tell us 'Why this person be highlighted in the Faces of Mass Spectrometry and/or How does this person represent diversity in the ASMS? (asms.org)
- As an initiative of the recently formed ASMS Diversity and Outreach Working Group, the editors are pleased to introduce a new "Faces of Mass Spectrometry" interview series in the Journal of the American Society of Mass Spectrometry. (asms.org)
Field of mass spectrometry1
- The technological advancements and breakthroughs in the field of mass spectrometry such as increased speed, higher accuracy, improved resolution, and miniaturization are expected to drive the global market in the coming years. (pitchengine.com)
Analysis26
- The Mass Spectrometry Data Center measures, compiles, evaluates, and correlates Standard Reference Data and develops and disseminates associated electronic databases and analysis software for industrially and environmentally important (bio)molecules. (nist.gov)
- The services are provided with full "beginning-to-end" support that includes project evaluation and design, biochemical purifications, mass spectrometry sequencing, and data analysis performed within the core and by the experienced core personnel. (bcm.edu)
- The trend towards biological analysis at increasingly smaller scales, ultimately down to the volume of an individual cell, continues, and mass spectrometry with a sensitivity of a few to single molecules will be necessary. (nature.com)
- Domon, B. & Aebersold, R. Mass spectrometry and protein analysis. (nature.com)
- Services include GC-MS analysis, LC-MS analysis, accurate mass determinations and Proteomic analysis. (sun.ac.za)
- During the past ten years a variety of methods involving mass spectrom- etry have been developed for the analysis of environmentally important compounds. (springer.com)
- How to get the most out of your mass spectrometry analysis. (uoguelph.ca)
- The Genedata session at the Biotherapeutics Analytical Summit will demonstrate how leading pharmaceutical companies have successfully automated the analysis of mass spectrometry data for site-specific glycosylation of biopharmaceuticals. (prweb.com)
- Genedata Expressionist for Mass Spectrometry Poster Session: Bioanalytical Mass Spectrometry application for sequence identification, quantifying PTMs, intact protein, and host cell protein impurity analysis. (prweb.com)
- ACD/Labs' mass spectrometry software offers a range of options, from routine to advanced packages, for ensuring efficient and effective MS data handling and analysis for small molecules. (acdlabs.com)
- Means of delivering nonvolatile analytes into the gas phase for mass analysis. (edu.au)
- Ambient ionization mass spectrometric analysis of human surgical specimens to distinguish renal cell carcinoma from healthy renal tissue. (urotoday.com)
- Planar Chromatography-Mass Spectrometry focuses on a relatively new approach to chemical analysis in general, and to separation science in particular. (routledge.com)
- Use this standard, a highly validated mammalian protein digest, as a quality control sample for mass spectrometry (MS) analysis of complex proteomic samples. (fishersci.com)
- Calibrate and maintain quality control for liquid chromatography (LC) and mass spectrometry (MS) analysis of proteomic samples using the carefully validated Thermo Scientific™ Pierce™ BSA Protein Digest Standard, LC-MS Grade. (fishersci.com)
- Separation of complex mixtures using hyphenated techniques e.g. ion mobility mass spectrometry, gas chromatography, ultra-high pressure liquid chromatography, direct analysis in real-time ionisation. (gre.ac.uk)
- Each chapter provides guidance in using the appropriate methods for isolating and purifying the compound class prior to mass spectrometric analysis. (wiley.com)
- The methods further involve integrating data obtained from mass spectrometry analysis of a plurality of series of hydrolyzed polymer fragments, and optionally provide statistical interpretation paradigms and computer software therefor. (google.com)
- 19. The method of claim 1 wherein step (c) is accomplished using mass analysis modes selected from the group consisting of: time-of-flight, quadrapole, ion trap, and sector. (google.com)
- A method apparatus wherein a plurality of electric fields and of orthogonal spray configurations of vaporized analyte are so combined as to enhance the efficiency of analyte detection and mass analysis. (google.com)
- Ambient mass spectrometry imaging is a very new development and has already a wide range of application, especially in qualitative surface analysis. (wur.nl)
- Macroscopic and microscopic spatially-resolved analysis of food contaminants and constituents using laser-ablation electrospray ionization mass spectrometry imaging. (wur.nl)
- g , specific MALDI imaging analysis using the Tag-mass concept with anti-C-terminal REG-α and an anti-human IgG tag (reporter m/z 1309) and anti-orosomucoid and anti-human monoclonal antibody (reporter m/z 1569). (mcponline.org)
- There is disclosed an apparatus for providing an ionized analyte for mass analysis by photon desorption comprising at least one layer (11) for contacting an analyte, and a substrate (10) on which said layer (11) is deposited. (google.ca)
- Upon irradiation of said app aratus, said analyte desorbs and ionizes for analysis by mass spectrometry. (google.ca)
- a substrate on which said layer is deposited, wherein said analyte upon irradiation of said apparatus with a photon source desorbs and ionizes for mass analysis. (google.ca)
Ions17
- Mass spectrometry ( MS ) is an analytical technique that is used to measure the mass-to-charge ratio of ions . (wikipedia.org)
- These ions (fragments) are then separated according to their mass-to-charge ratio, for example by accelerating them and subjecting them to an electric or magnetic field: ions of the same mass-to-charge ratio will undergo the same amount of deflection. (wikipedia.org)
- [2] [3] Early spectrometry devices that measured the mass-to-charge ratio of ions were called mass spectrographs which consisted of instruments that recorded a spectrum of mass values on a photographic plate . (wikipedia.org)
- [4] [5] A mass spectroscope is similar to a mass spectrograph except that the beam of ions is directed onto a phosphor screen. (wikipedia.org)
- Mass spectrometry , also called mass spectroscopy , analytic technique by which chemical substances are identified by the sorting of gaseous ions in electric and magnetic fields according to their mass-to-charge ratios . (britannica.com)
- As the ions pass through the magnetic field, they are deflected into a curved path that is dependent on both their charge and mass. (britannica.com)
- Ions of different mass travel along a different trajectory before reaching a detector, which records the intensities and masses of the ions that strike it. (britannica.com)
- A method comprising using a first mass analyzer of a downhole tool to isolate specific ions within a sample received in the downhole tool, using a second mass analyzer of the downhole tool to stabilize the ions isolated by the first mass analyzer, and using a third mass analyzer of the downhole tool to catalog the stabilized ions. (freepatentsonline.com)
- and using a third mass analyzer of the downhole tool to catalog the stabilized ions. (freepatentsonline.com)
- Sodium atoms and ions are monoisotopic , with a mass of about 23 amu. (newworldencyclopedia.org)
- Has a mass range for singly charged ions of 10-2000 Daltons with unit resolution across the entire mass range. (edu.au)
- One possibility would be to produce multiply charged ions and detect them in a more accessible mass-to-charge ratio range. (innovations-report.com)
- Time-of-flight mass spectrometry (TOF-MS) is a method of mass spectrometry in which ions mass-to-charge ratio is determined via a time measurement. (gre.ac.uk)
- Rapid (ms) separation of ions based on shape, mass and charge. (gre.ac.uk)
- The invention relates to a method and apparatus for obtaining improved signal relative to noise without loss of ion collection efficiency for use in mass spectrometry, including LC/MS (liquid chromatography/mass spectrometry), especially as regards the technique of generating analyte ions known as Atmospheric Pressure Chemical Ionization (APCI). (google.com)
- An extraction system removes ions from the sample, which are then targeted through the mass analyzer and into the detector. (wikipedia.org)
- The differences in masses of the fragments allows the mass analyzer to sort the ions by their mass-to-charge ratio. (wikipedia.org)
Spectroscopy3
- [7] The use of the term mass spectroscopy is now discouraged due to the possibility of confusion with light spectroscopy . (wikipedia.org)
- The foundation of mass spectroscopy was laid in 1898, when Wilhelm Wien, a German physicist, discovered that beams of charged particles could be deflected by a magnetic field . (britannica.com)
- Advanced prediction, processing, and interpretation software for mass spectroscopy techniques. (acdlabs.com)
Chemistry7
- Mass spectroscopes also are employed to separate isotopes and to measure the abundance of concentrated isotopes when used as tracers in chemistry , biology, and medicine . (britannica.com)
- This article will walk you through the unassuming but handy field of chemistry known as mass spectrometry . (howstuffworks.com)
- Practical MS Education Package This package contains all the materials and equipment needed to introduce a practical course in MS fundamentals in which your organic chemistry students will have the opportunity to generate and interpret mass data themselves. (waters.com)
- The Mass Spectrometry Group in the School of Chemistry at the University of Southampton was established in 1988 and has a research history including work in the early days of Fullerenes with the Sussex Group, introduction of the first open access MS system to academia, combichem, and applications in DNA research. (southampton.ac.uk)
- The journal invites papers in all fundamental aspects of mass spectrometry and ion processes , including instrumental developments and applications in biology , chemistry , geology and physics . (elsevier.com)
- The American Association for Clinical Chemistry (AACC), states that the greater specificity of liquid chromatography-mass spectrometry-(LC MS) enables the measuring of testosterone for patients with low endogenous concentrations. (openpr.com)
- Some mass spectrometrists use the definition that is similar to definitions used in some other fields of physics and chemistry. (wikipedia.org)
Mixtures2
- Mass spectrometry is used in many different fields and is applied to pure samples as well as complex mixtures. (wikipedia.org)
- This book overviews the combination of planar chromatography, a relatively simple and cost-effective separation step for determining complex mixtures of compounds, with mass spectrometry, an efficient, highly instrumental, and relatively expensive technique that enables rapid identification of separated chemical species. (routledge.com)
Triple Quadrupole3
- These capabilities include advanced sample preparation combined with both LC-MS and GC-MS. High resolution accurate mass (HRAM) hyphenated with both GC and LC separation, enhanced-resolution triple quadrupole hyphenated with GC instrument and triple quadrupole LC systems for routine quantitation. (intertek.com)
- Obtain both positive and negative ionization calibration of Thermo Scientific™ Triple Stage Quadrupole instruments using the Thermo Scientific™ Pierce™ Triple Quadrupole Calibration Solution, Extended Mass Range, which is a mixture of 14 highly pure, ionizable components (mass range: 69 m/z to 2800m/z). (fishersci.com)
- The Quantum is a triple quadrupole instrument with high sensitivity and a broad mass range. (carolinashealthcare.org)
Analytical technique2
- Gas chromatography-mass spectrometry (GC-MS) is a hybrid analytical technique that couples the separation capabilities of GC with the detection properties of MS to provide a higher efficiency of sample analyses. (news-medical.net)
- Mass spectrometry is an analytical technique that identifies the chemical composition of a compound or sample based on the mass-to-charge ratio of charged particles. (newworldencyclopedia.org)
Molecules3
- Matrix-assisted laser desorption ionization can be used as a mass spectrometry imaging technique for relatively large molecules. (wikipedia.org)
- With origins in basic research, mass spectrometry emerged as a clinical research tool when it was first applied to fingerprint molecules for drug screening in the fight against drugs of abuse. (thefreedictionary.com)
- 3. The apparatus of claim 2 wherein the analytical apparatus is capable of detecting and measuring the mass and charge of ionized molecules which have been communicated from the second passageway exit into the analytical apparatus. (google.com)
Protein4
- In our nanoelectromechanical-mass spectrometry system, nanoparticles and protein species are introduced by electrospray injection from the fluid phase in ambient conditions into vacuum, and are subsequently delivered to the nanoelectromechanical system detector by hexapole ion optics. (nature.com)
- Therefore, PTB has developed Isotope Dilution Mass Spectrometry (ID-MS) for protein markers, expanding the scope of SI-traceable Reference Measurement to this important class of clinical measurands. (ptb.de)
- Mass spectrometric protein quantification is used to explore measurands for research purposes in general. (ptb.de)
- Mass spectrometry services are critical to protein therapeutics in all stages of development from pre-clinical to licensure. (criver.com)
Thermo Scientific1
- The Thermo Scientific Exactive GC (HRAM with 60,000 resolution and sub ppm mass accuracy, CI capability without vacuum venting) with SPME, static headspace (SHS) and multiple liquid injection capabilities supports component identification, elemental composition confirmation and MS quantitation. (intertek.com)
Metabolomics1
- Etalo D, de Vos RCH, Joosten MHAJ, Hall RD. Spatially-resolved plant metabolomics: some potentials and limitations of Laser-Ablation Electrospray Ionization (LAESI) Mass Spectrometry metabolite imaging. (wur.nl)
Isotope4
- The ion of mass 22 was, in fact, a stable heavy isotope of neon. (britannica.com)
- So, when you do mass spectrometry, you get two signals of different intensities depending on the natural abundance of each isotope. (physicsforums.com)
- This series of rapid acquisitions has positioned GV Instruments to be a major player in inorganic mass spectrometry , especially isotope ratio mass spectrometry (ISMS). (thefreedictionary.com)
- Mass spectrometry - finds the mass of molecule/isotope by measuring mass-to-charge ratio. (thestudentroom.co.uk)
Ionization6
- Touch spray-mass spectrometry (TS-MS) is an ambient ionization technique (ionization of unprocessed samples in the open air) that may find intraoperative applications in quickly identifying the disease state of cancerous tissues and in defining surgical margins. (urotoday.com)
- Diagnosis of prostate cancer by desorption electrospray ionization mass spectrometric imaging of small metabolites and lipids. (urotoday.com)
- We performed desorption electrospray ionization mass spectrometry imaging (DESI-MSI) on 54 banked human cancerous and normal prostate tissue specimens to investigate the spatial distribution of a wide variety of small metabolites, carbohydrates, and lipids. (urotoday.com)
- As an undergraduate student researcher in the Bush Lab, Evan investigated fundamental aspects of electrospray ionization in the context of native mass spectrometry. (washington.edu)
- Biological tissues and aqueous samples are readily analyzed using a mid-infrared laser (2940 nm) in Laser Ablation Electrospray Ionization Mass Spectrometry (or LAESI-MS). The wavelength corresponds to the frequency of the O-H bond vibrations in water, therefore it results in the strong absorption of this wavelength by the water. (wur.nl)
- Ionization methods in organic mass spectrometry. (wikipedia.org)
Laboratory2
- 24 October 2011 - UK pharmaceutical company Almac Group Ltd announced it had established a mass spectrometry laboratory at its headquarters in Northern Ireland worth GBP1m (USD1. (thefreedictionary.com)
- Techniques to detect such compounds already exist, but these methods, such as mass spectrometry, are mostly confined to the laboratory because they are too bulky and complex to provide real-time, portable detection. (theengineer.co.uk)
Methods5
- In Mass Spectrometry of Glycoproteins: Methods and Protocols, expert researchers in the field detail many of the methods that are now commonly used for glycoproteomics. (springer.com)
- Authoritative and practical, Mass Spectrometry of Glycoproteins: Methods and Protocol is an essential resource for those who work at the interface of glycobiology and mass spectrometry. (springer.com)
- Aiming to improve power and efficiency when other analytical methods are inadequate, Planar Chromatography-Mass Spectrometry encourages separation science practitioners in academia and industry to combine the two methods for enhanced results. (routledge.com)
- This unusual text is not simply a compilation of mass spectrometric methods but provides, instead, insight into specific approaches mass spectroscopists use when applying the technique to a variety of biological problems. (wiley.com)
- The methods and apparatus disclosed herein are useful for sequencing polymers using mass spectrometry. (google.com)
Analyzer4
- The positively charged fragments (which for simplicity are considered here to bear only a single positive charge) are then accelerated by an electric field and directed into a mass analyzer. (britannica.com)
- This system (installed end 2015) combines a state-of-the-art segmented quadrupole for high-performance precursor ion selection with a high-resolution, accurate-mass (HR/AM) ultra-high-field Orbitrap mass analyzer to deliver a superior combination of scan speed, resolving power, mass accuracy, spectral quality and sensitivity. (edu.au)
- Since its introduction, the orbitrap has proven to be a robust mass analyzer that can routinely deliver high resolving power and mass accuracy. (psu.edu)
- The large mass range of the TOF analyzer makes the instrument well suited for detecting trace levels of organic contaminants on surfaces. (nrel.gov)
Analytes1
- Precipitous frequency shifts, proportional to the mass, are recorded in real time as analytes adsorb, one by one, onto a phase-locked, ultrahigh-frequency nanoelectromechanical resonator. (nature.com)
MALDI TOF2
- The presentation will give a current overview of label-free high-throughput MALDI TOF mass spectrometry and its use in drug discovery screening. (news-medical.net)
- It will explain the basics of MALDI TOF mass spectrometry and the benefits of label-free screening compared to current labeled approaches. (news-medical.net)
Detector1
- The improved ultrafast, 2-μm-pore MCP TOF detector offered by Burle Electro-Optics Inc. is suitable for mass spectrometry applications. (photonics.com)
Molecule4
- Here, we report the first demonstration of mass spectrometry based on single biological molecule detection with a nanoelectromechanical system. (nature.com)
- Figure 2: Real-time records of single-molecule adsorption events on a NEMS mass sensor. (nature.com)
- Mass spectrometry is a highly-specific and sensitive technique for the determination of the chemical structure and quantification of compounds based on ionizing and breaking down the molecule into specific fragments. (cincinnatichildrens.org)
- ACD/Labs' Mass Spectrometry software offers efficient and effective ways to handle small molecule MS data from routine processing, advanced processing, and interpretation to databasing and reporting. (acdlabs.com)
University of Mass1
- Mass Analyzers presented by Richard Vachet (University of Massachusetts Amherst) on June 9, 2013. (asms.org)
Isotopes1
- A simulation of Chlorine isotopes along with an average atomic mass calculation is included. (curriki.org)
Sensitivity3
- Using this technique has resulted in an increase of sensitivity for larger mass samples. (wikipedia.org)
- Accurate mass measurements to determine elemental composition, high sensitivity MS and MS/MS measurements. (gre.ac.uk)
- Figures of merit such as resolving power, mass accuracy, dynamic range and sensitivity of each type of instrument are compared. (psu.edu)
Compounds3
- with appropriate calibration compounds, mass determination to several thousand Da can be routine. (umsl.edu)
- This permits compounds to be assigned to the Δ 4 or Δ 5 series on the basis of mass-spectrometric data. (springer.com)
- The volatile compounds in Roselle extract and dried samples were performed using needles of solid phase microextraction (SPME) and gas chromatography/mass spectrometry (GC/MS HP-5890). (scribd.com)
Researchers1
- Dr. Mikhael feels that screening studies, such as iStopMM , will use mass spectrometry to allow for researchers to better understand the biology of the disease and be able to detect myeloma at lower levels. (myeloma.org)
Bruker1
- By Bruker Corporation based in Billerica, MASSACHUSETTS (USA) . (environmental-expert.com)
Quadrupole mass1
- Single Quadrupole Mass Detection Waters innovative single quadrupole mass detectors are designed for robustness, to make access to mass spectral data easy for scientists with all levels of expertise. (waters.com)
Detection2
- This benchtop LC-MS/MS system combines quadruple precursor ion selection with high-resolution, accurate-mass (HRAM) Orbitrap detection to deliver exceptional performance and versatility. (environmental-expert.com)
- Mass spectrometry, with its inherently high selectivity, has the promise to furnish much better resolution and is being investigated as a tool for detection and evaluation of isoforms. (ptb.de)
Spectrometric3
- The Mass Spectrometry Unit, part of the Central Analytical Facilities of Stellenbosch University, serves as a resource offering contemporary mass spectrometric techniques and the 'state-of-the-art' instrumen-tation needed for the diversity of research interests on- and off-campus. (sun.ac.za)
- Below is a brief overview of the major mass spectrometric applications we currently support. (gre.ac.uk)
- We perform research-based mass spectrometric (MS) and high-throughput (HTS) analyses for SINTEF, academia and industry. (sintef.no)
Separation1
- There are several ways to define the minimum peak separation ΔM in mass spectrometry, therefore it is important to report the method used to determine mass resolution when reporting its value. (wikipedia.org)
Applications3
- The Warwick Mass Spectrometry community includes scientists with a wide range of technical and applications expertise. (warwick.ac.uk)
- This report covers the definition, description, and forecast of the mass spectrometry market in terms of technologies and applications. (pitchengine.com)
- Mass Spectrometry: Organic Chemical Applications. (wikipedia.org)