MARVEL Domain-Containing Proteins
MARVEL Domain Containing 2 Protein
Madin Darby Canine Kidney Cells
Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells. (1/20)
For epithelia to function as barriers, the intercellular space must be sealed. Sealing two adjacent cells at bicellular tight junctions (bTJs) is well described with the discovery of the claudins. Yet, there are still barrier weak points at tricellular contacts, where three cells join together. In this study, we identify tricellulin, the first integral membrane protein that is concentrated at the vertically oriented TJ strands of tricellular contacts. When tricellulin expression was suppressed with RNA interference, the epithelial barrier was compromised, and tricellular contacts and bTJs were disorganized. These findings indicate the critical function of tricellulin for formation of the epithelial barrier. (+info)Tricellulin is a tight-junction protein necessary for hearing. (2/20)
The inner ear has fluid-filled compartments of different ionic compositions, including the endolymphatic and perilymphatic spaces of the organ of Corti; the separation from one another by epithelial barriers is required for normal hearing. TRIC encodes tricellulin, a recently discovered tight-junction (TJ) protein that contributes to the structure and function of tricellular contacts of neighboring cells in many epithelial tissues. We show that, in humans, four different recessive mutations of TRIC cause nonsyndromic deafness (DFNB49), a surprisingly limited phenotype, given the widespread tissue distribution of tricellulin in epithelial cells. In the inner ear, tricellulin is concentrated at the tricellular TJs in cochlear and vestibular epithelia, including the structurally complex and extensive junctions between supporting and hair cells. We also demonstrate that there are multiple alternatively spliced isoforms of TRIC in various tissues and that mutations of TRIC associated with hearing loss remove all or most of a conserved region in the cytosolic domain that binds to the cytosolic scaffolding protein ZO-1. A wild-type isoform of tricellulin, which lacks this conserved region, is unaffected by the mutant alleles and is hypothesized to be sufficient for structural and functional integrity of epithelial barriers outside the inner ear. (+info)Transmembrane proteins of tight junctions. (3/20)
Tight junctions contribute to the paracellular barrier, the fence dividing plasma membranes, and signal transduction, acting as a multifunctional complex in vertebrate epithelial and endothelial cells. The identification and characterization of the transmembrane proteins of tight junctions, claudins, junctional adhesion molecules (JAMs), occludin and tricellulin, have led to insights into the molecular nature of tight junctions. We provide an overview of recent progress in studies on these proteins and highlight their roles and regulation, as well as their functional significance in human diseases. (+info)Splice-site mutations in the TRIC gene underlie autosomal recessive nonsyndromic hearing impairment in Pakistani families. (4/20)
Hereditary hearing impairment (HI) displays extensive genetic heterogeneity. To date, 67 autosomal recessive nonsyndromic hearing impairment (ARNSHI) loci have been mapped, and 24 genes have been identified. This report describes three large consanguineous ARNSHI Pakistani families, all of which display linkage to marker loci located in the genetic interval of DFNB49 locus on chromosome 5q13. Recently, Riazuddin et al. (Am J Hum Genet 2006; 79:1040-1051) reported that variants within the TRIC gene, which encodes tricellulin, are responsible for HI due to DFNB49. TRIC gene sequencing in these three families led to the identification of a novel mutation (IVS4+1G> A) in one family and the discovery of a previously described mutation (IVS4+2T> C) in two families. It is estimated that 1.06% (95% confidence interval 0.02-3.06%) of families with ARNSHI in Pakistan manifest HI due to mutations in the TRIC gene. (+info)Knockout animals and natural mutations as experimental and diagnostic tool for studying tight junction functions in vivo. (5/20)
(+info)Loss of occludin affects tricellular localization of tricellulin. (6/20)
(+info)Tricellulin forms a barrier to macromolecules in tricellular tight junctions without affecting ion permeability. (7/20)
(+info)Tight junction-associated MARVEL proteins marveld3, tricellulin, and occludin have distinct but overlapping functions. (8/20)
(+info)I'm sorry for any confusion, but "MARVEL Domain-Containing Proteins" is not a widely recognized or established term in medicine or molecular biology. MARVEL (MAL and related proteins for vesicle trafficking and membrane link) is a domain found in some proteins that are involved in various cellular processes such as membrane trafficking, maintenance of cell junctions, and regulation of the immune system. However, it's not a term commonly used to describe a specific group of proteins or a clinical condition. If you have more context or information about where you encountered this term, I might be able to provide a more precise explanation.
I'm sorry for any confusion, but "MARVEL Domain Containing 2 Protein" doesn't seem to correspond to a recognized medical term or protein name in human biology. The term "MARVEL" (MAL and related proteins for vesicle trafficking and membrane link) is a domain found in some proteins that are involved in various cellular processes such as membrane trafficking, cell adhesion, and signal transduction. However, without a specific protein name, it's difficult to provide a precise medical definition.
If you meant a specific protein containing the MARVEL domain, please provide the name so I can give a more detailed and accurate description.
Madin-Darby Canine Kidney (MDCK) cells are a type of cell line that is derived from the kidney of a normal, healthy female cocker spaniel. They were first established in 1958 by researchers Madin and Darby. These cells are epithelial in origin and have the ability to form tight junctions, which makes them a popular choice for studying the transport of molecules across biological barriers.
MDCK cells are widely used in scientific research, particularly in the fields of cell biology, virology, and toxicology. They can be used to study various aspects of cell behavior, including cell adhesion, migration, differentiation, and polarization. Additionally, MDCK cells are susceptible to a variety of viruses, making them useful for studying viral replication and host-virus interactions.
In recent years, MDCK cells have also become an important tool in the development and production of vaccines. They can be used to produce large quantities of virus particles that can then be purified and used as vaccine antigens. Overall, Madin-Darby Canine Kidney cells are a valuable resource for researchers studying a wide range of biological phenomena.
Occludin is a protein that is a component of tight junctions, which are structures that form a barrier between adjacent cells in epithelial and endothelial tissues. Tight junctions help to regulate the movement of molecules between cells and play a crucial role in maintaining the integrity of these tissues.
Occludin is composed of four transmembrane domains, two extracellular loops, and intracellular N- and C-termini. The extracellular loops interact with other tight junction proteins to form the intercellular seal, while the intracellular domains interact with various signaling molecules and cytoskeletal components to regulate the assembly and disassembly of tight junctions.
Mutations in the gene that encodes occludin have been associated with various human diseases, including inflammatory bowel disease, liver cirrhosis, and skin disorders. Additionally, changes in occludin expression and localization have been implicated in the development of cancer and neurological disorders.
MARVELD2
CKLF-like MARVEL transmembrane domain-containing family
CMTM2
Undifferentiated pleomorphic sarcoma
CKLF like MARVEL transmembrane domain-containing 1
CKLF (gene)
Chromosome 16
Chromosome 3
CKLF like MARVEL transmembrane domain-containing 4
CKLF like MARVEL transmembrane domain-containing 8
CKLF like MARVEL transmembrane domain containing 6
CMTM3
CKLF-like MARVEL transmembrane domain-containing 5
Proteinoid
Alternative abiogenesis scenarios
Pride and Prejudice
Endothelial NOS
Wilhelm Röntgen
Gene desert
Telomeric repeat-binding factor 2
The Avengers (2012 film)
Love
Cocaine
Fluorine
List of University of Pennsylvania people
Cerebellum
Javanese people
Man of Steel (film)
History of agriculture in China
Frankenstein in popular culture
MARVELD2 - Wikipedia
Recombinant Human MARVELD1 protein (ABIN3106013)
MARVELD3 | Gene Information | J-GLOBAL
PHYRE Protein Fold Recognition Server
Immune cell - IFRD1 - The Human Protein Atlas
Pesquisa | Prevenção e Controle de Câncer
Fused inverse-normal method for integrated differential expression analysis of RNA-seq data | BMC Bioinformatics | Full Text
SAUSA300 RS01030 - AureoWiki
Gene Set - mRNA KAT5 22196727
GSE7460 FOXP3 MUT VS WT ACT TCONV UP
MH DELETED MN ADDED MN
MH DELETED MN ADDED MN
MH DELETED MN ADDED MN
MH DELETED MN ADDED MN
MH DELETED MN ADDED MN
Publications | Institute for Structural and Chemical Biology | University of Leicester
Mechanical cell competition kills cells via induction of lethal p53 levels | Nature Communications
Marcus Wolfe
Dana-Farber Cancer Institute | Alex's Lemonade Stand Foundation for Childhood Cancer
GSE43955 1H VS 10H ACT CD4 TCELL WITH TGFB IL6 DN
Synaptogyrins | Profiles RNS
What Sugar Is Found In RNA And DNA? - Database Football
Progressive axonopathy when oligodendrocytes lack the myelin protein CMTM5 :: MPG.PuRe
miRNA-183 Suppresses Apoptosis and Promotes Proliferation in Esophageal Cancer by Targeting PDCD4
The Miracle of Water: The Yin & the Yang
BlueGen ELISAs - Assay Kits - assayspro.com
Liste des publications 2011
Steeler Gi Joe
Kung Chun Chiu's Profile | Stanford Profiles
Recombinant proteins2
- The concentration of our recombinant proteins is measured using the absorbance at 280nm. (antibodies-online.com)
- From monoclonal antibodies to recombinant proteins, biopharmaceuticals offer targeted and often more effective therapies. (etechlimit.com)
Subfamily1
- A subfamily of MARVEL domain-containing proteins that are found in SYNAPTIC VESICLES, where they may play a role in modulating neuronal signaling. (ouhsc.edu)
Subunit1
- cleavage stimulation factor subunit 2 [S. (gsea-msigdb.org)
Source:HGNC Symb2
- chromodomain Y like 2 [Source:HGNC Symb. (gsea-msigdb.org)
- c-Maf inducing protein [Source:HGNC Symb. (gsea-msigdb.org)
Autophagy associated2
- We have determined the ability of 83 proteins of several families of RNA viruses (Paramyxoviridae, Flaviviridae, Orthomyxoviridae, Retroviridae and Togaviridae), to interact with 44 human autophagy-associated proteins using yeast two-hybrid and bioinformatic analysis. (sfr-biosciences.fr)
- Interestingly, immunity-associated GTPase family M (IRGM), the most targeted protein, was found to interact with the autophagy-associated proteins ATG5, ATG10, MAP1CL3C and SH3GLB1. (sfr-biosciences.fr)
Transmembrane3
- CKLF like MARVEL transmembrane domain co. (gsea-msigdb.org)
- Here, we find that expression of the tetraspan-transmembrane protein CMTM5 (chemokine-like factor-like MARVEL-transmembrane domain containing protein 5) is highly enriched in oligodendrocytes and central nervous system (CNS) myelin. (mpg.de)
- Chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing family ( CMTM ) is a gene family involved in multiple malignancies. (biomedcentral.com)
Genes4
- 185 genes in signature reported in the publication with PubMedID mRNA_KAT5_22196727 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. (maayanlab.cloud)
- One of the ribose's key functions is that it acts as the base for the genetic tool that makes proteins out of genes. (databasefootball.com)
- In contrast, the Fushi Tarazu homeodomain protein is an activator, both in cultured cells and in Drosophila embryos, where it activates several known target genes, including its own gene. (biologists.com)
- Dr. Zee explained that three scientists recently shared the Nobel Prize for Medicine for their work in the early 1980's identifying the genes and protein molecules that drive our twenty-four-hour biological clocks, often referred to as our "circadian rhythm. (c2st.org)
Synthesis4
- While DNA is responsible for storing genetic information, it is RNA that codes for the synthesis of amino acids and carries information between ribosomes and DNA, allowing ribosomes to make proteins. (databasefootball.com)
- There are three primary types of RNA that are involved in the synthesis of proteins. (databasefootball.com)
- Ribose is found in mRNA, and mRNA plays an important role in protein synthesis for eukaryotic hours. (databasefootball.com)
- Post exercise carbohydrate-protein supplementation: phosphorylation of muscle halo infinite hack client involved in glycogen synthesis and protein translation. (ramc.be)
Homolog3
- Discs Large Homolog 1 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
- This graph shows the total number of publications written about "Discs Large Homolog 1 Protein" by people in this website by year, and whether "Discs Large Homolog 1 Protein" was a major or minor topic of these publications. (umassmed.edu)
- Below are the most recent publications written about "Discs Large Homolog 1 Protein" by people in Profiles. (umassmed.edu)
Ribosomal1
- protein_coding" "Cz04g10270.t1","No alias","Chromochloris zofingiensis","Ribosomal protein L1/ribosomal biogenesis protein [Interproscan]. (ntu.edu.sg)
Immune4
- NLRP1 (NACHT and leucine-rich repeat-containing protein family, pyrin domain-containing protein 1) is an innate immune sensor that is involved in the formation of inflammasome complexes. (frontiersin.org)
- Members of the nucleotide-binding domain (NACHT) and leucine-rich repeat-containing protein family (NLR) are known to be innate immune sensors. (frontiersin.org)
- Recognition of the inflammatory ligand results in the formation of inflammasomes ( 3 , 6 ), which are multi-protein signaling hubs that initiate immune responses by recruiting and activating proteases, such as caspase-1 (Casp-1) ( 4 - 7 ). (frontiersin.org)
- Using this assembly we cloned fort scott the broad spectrum lr22a leaf rust resistance gene, using molecular marker informa on and ethyl methanesulfonate ems mutants, and found that lr22a encodes an intracellular calhoun immune receptor homologous to iqaluit the arabidopsis thaliana rpm1 protein. (marmisur.com)
Kinase1
- A-kinase anchoring protein 7 [Source:HG. (gsea-msigdb.org)
Zinc1
- alpha-2-glycoprotein 1, zinc-binding [So. (gsea-msigdb.org)
Membrane protein1
- small integral membrane protein 3 [Sour. (gsea-msigdb.org)
Carbohydrates1
- The Krebs cycle is a series of chemical reactions that derive energy out of carbohydrates, proteins, and fats. (databasefootball.com)
Chemotherapy and radiotherapy1
- MCL-1 is a pro-survival BCL-2 family member that has emerged as a ubiquitous chemotherapy and radiotherapy resistance factor in pediatric cancer. (alexslemonade.org)
Enoyl1
- Enoyl-(Acyl carrier protein) reductase [Interproscan]. (ntu.edu.sg)
Symbol3
- acylphosphatase 2 [Source:HGNC Symbol;A. (gsea-msigdb.org)
- docking protein 2 [Source:HGNC Symbol;A. (gsea-msigdb.org)
- desmoglein 2 [Source:HGNC Symbol;Acc:HG. (gsea-msigdb.org)
Homeodomain1
- The Engrailed homeodomain protein is an 'active' or dominant transcriptional repressor in cultured cells. (biologists.com)
Superheroes1
- Keaton was an affectionate little boy with a love for Marvel superheroes, especially Captain America. (alexslemonade.org)
Superfamily1
- The first one provides length variation at the N-terminus (before the BH4 domain) and the second one is located between the predicted alpha 5-alpha 6 pore-forming helices, providing an unprecedented case in the superfamily of helix-bundled pore-forming proteins. (sfr-biosciences.fr)
Cellular3
- A specialized group of proteins, called the BCL-2 family, regulates the natural balance between cellular life and death, ensuring that essential cells are preserved and damaged cells eliminated. (alexslemonade.org)
- cellular retinoic acid binding protein 2. (gsea-msigdb.org)
- Although central to autophagy, targeted proteins have also a high number of connections with proteins of other cellular functions. (sfr-biosciences.fr)
Technological1
- This paragon of technological marvel, the most sophisticated telescope to grace our age, promises insights that will chart the course for interstellar voyages for epochs to come. (future-assets.com)
MRNA1
- mRNA copies the genetic code from DNA and brings this information to the ribosomes, which are able to read the sequences of A, G, C and U. Thanks to this process the correct proteins will be synthesized by the ribosomes, and the mRNA will then typically break apart. (databasefootball.com)
Motif2
- This is accomplished at the molecular level by a specialized surface on survival proteins, called the "anti-apoptotic groove," which neutralizes a helically-shaped motif, called "the BH3 domain," essential to the killing activity of the death proteins. (alexslemonade.org)
- While deletion of the N-terminal extension had no significant functional impact in HeLa cells, our results suggest that the human Bcl2l10 protein evolved a calcium-binding motif in its alpha 5-alpha 6 interhelical region by acquiring critical negatively charged residues. (sfr-biosciences.fr)
Crystallization1
- Human MARVELD1 Protein (raised in Insect Cells) purified by multi-step, protein-specific process to ensure crystallization grade. (antibodies-online.com)
Amino-acid2
- In the warm embrace of July 2022, Deep Mind unveiled a revelation: the complex 3D tapestry of a protein can be divined from its linear amino-acid soliloquy, courtesy of the prodigious algorithms AlphaFold2, RoseTTAFold, and trRosettaX-Single. (future-assets.com)
- Figure 1 Homology in domain structures and amino acid sequences between human and mouse NLRP1 and the present knock-in mutation. (frontiersin.org)
Complement1
- complement C3d receptor 2 [Source:HGNC S. (gsea-msigdb.org)
Collagen3
- collagen type I alpha 2 chain [Source:HG. (gsea-msigdb.org)
- collagen type IV alpha 2 chain [Source:H. (gsea-msigdb.org)
- collagen type V alpha 2 chain [Source:HG. (gsea-msigdb.org)
Family member3
- Cas scaffold protein family member 4 [S. (gsea-msigdb.org)
- Considering the reliance of female eggs on calcium-dependent proteins and calcium-regulated processes and the exceptional longevity of oocytes in the primate lineage, we propose that this microstructural variation may be an adaptive feature associated with high maternal expression of this Bcl-2 family member. (sfr-biosciences.fr)
- Inflammasomes consist of apoptosis-associated speck-like protein containing CARD (ASC), Casp-1, and a sensor protein, such as an NLR family member ( 9 ). (frontiersin.org)
Receptor2
- bone morphogenetic protein receptor type. (gsea-msigdb.org)
- Kim E, Cho KO, Rothschild A, Sheng M. Heteromultimerization and NMDA receptor-clustering activity of Chapsyn-110, a member of the PSD-95 family of proteins. (umassmed.edu)
Reliance1
- Accelerating sales in startups: A domain planning, network reliance, and resource complementary perspective", Journal of Small Business Management . (ou.edu)
Tissues1
- HCC tissues from patients had higher levels of PVRL1 messenger RNA and protein than nontumorous tissues. (stanford.edu)
Humans2
- MARVEL domain-containing protein 2 is a protein that in humans is encoded by the MARVELD2 gene. (wikipedia.org)
- This family is reported to include 22 members in humans ( 2 ). (frontiersin.org)
Functional3
- In addition to the applications listed above we expect the protein to work for functional studies as well. (antibodies-online.com)
- As the protein has not been tested for functional studies yet we cannot offer a guarantee though. (antibodies-online.com)
- However, the functional relevance of many myelin proteins has remained unknown. (mpg.de)
Member1
- Bcl2l10 is an antiapoptotic member of the Bcl-2 family that has evolved rapidly throughout the vertebrate lineage and which shows conserved abundant expression in eggs and oocytes. (sfr-biosciences.fr)
Comics1
- This crossfire noclip speed true to form with the comics, where Deadpool exists almost as a completely separate entity from the Marvel universe and many of his adventures are considered « non-canon » anyway. (ramc.be)
Structural1
- Insertions or deletions (indels) of amino acids residues have been recognized as an important source of genetic and structural divergence between paralogous Bcl-2 family members. (sfr-biosciences.fr)
Expression3
- In the unlikely event that the protein cannot be expressed or purified we do not charge anything (other companies might charge you for any performed steps in the expression process for custom-made proteins, e.g. fees might apply for the expression plasmid, the first expression experiments or purification optimization). (antibodies-online.com)
- Moreover we found that the expression of IRGM-interacting MeV-C, HCV-NS3 or HIV-NEF proteins per se is sufficient to induce autophagy, through an IRGM dependent pathway. (sfr-biosciences.fr)
- The ccRCC cell lines A498 and 786-O and the normal renal tubular epithelial cell line HK-2 were also tested for CMTM4 expression by western blotting. (biomedcentral.com)
Interaction1
- AT-rich interaction domain 3A [Source:H. (gsea-msigdb.org)