An RNA virus infection of rhesus, vervet, and squirrel monkeys transmissible to man.
A genus in the family FILOVIRIDAE consisting of one species (Lake Victoria marburgvirus) with several strains. The genus shows no antigenic cross-reactivity with EBOLAVIRUS.
An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)
A family of RNA viruses, of the order MONONEGAVIRALES, containing filamentous virions. Although they resemble RHABDOVIRIDAE in possessing helical nucleocapsids, Filoviridae differ in the length and degree of branching in their virions. There are two genera: EBOLAVIRUS and MARBURGVIRUS.
A genus in the family FILOVIRIDAE consisting of several distinct species of Ebolavirus, each containing separate strains. These viruses cause outbreaks of a contagious, hemorrhagic disease (HEMORRHAGIC FEVER, EBOLA) in humans, usually with high mortality.
A pathological process consisting of hardening or fibrosis of an anatomical structure, often a vessel or a nerve.
Infections with viruses of the family FILOVIRIDAE. The infections in humans consist of a variety of clinically similar viral hemorrhagic fevers but the natural reservoir host is unknown.
A highly fatal, acute hemorrhagic fever, clinically very similar to MARBURG VIRUS DISEASE, caused by EBOLAVIRUS, first occurring in the Sudan and adjacent northwestern (what was then) Zaire.
A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
Autosomal dominant neurocutaneous syndrome classically characterized by MENTAL RETARDATION; EPILEPSY; and skin lesions (e.g., adenoma sebaceum and hypomelanotic macules). There is, however, considerable heterogeneity in the neurologic manifestations. It is also associated with cortical tuber and HAMARTOMAS formation throughout the body, especially the heart, kidneys, and eyes. Mutations in two loci TSC1 and TSC2 that encode hamartin and tuberin, respectively, are associated with the disease.
A group of viral diseases of diverse etiology but having many similar clinical characteristics; increased capillary permeability, leukopenia, and thrombocytopenia are common to all. Hemorrhagic fevers are characterized by sudden onset, fever, headache, generalized myalgia, backache, conjunctivitis, and severe prostration, followed by various hemorrhagic symptoms. Hemorrhagic fever with kidney involvement is HEMORRHAGIC FEVER WITH RENAL SYNDROME.
A genus of anaerobic, rod-shaped METHANOBACTERIACEAE. Its organisms are nonmotile and use ammonia as the sole source of nitrogen. These methanogens are found in aquatic sediments, soil, sewage, and the gastrointestinal tract of animals.
A chronic multi-system disorder of CONNECTIVE TISSUE. It is characterized by SCLEROSIS in the SKIN, the LUNGS, the HEART, the GASTROINTESTINAL TRACT, the KIDNEYS, and the MUSCULOSKELETAL SYSTEM. Other important features include diseased small BLOOD VESSELS and AUTOANTIBODIES. The disorder is named for its most prominent feature (hard skin), and classified into subsets by the extent of skin thickening: LIMITED SCLERODERMA and DIFFUSE SCLERODERMA.
A republic in southern Africa, southwest of DEMOCRATIC REPUBLIC OF THE CONGO and west of ZAMBIA. Its capital is Luanda.
A republic in central Africa, east of the REPUBLIC OF THE CONGO, south of the CENTRAL AFRICAN REPUBLIC and north of ANGOLA and ZAMBIA. The capital is Kinshasa.
A form of multiple sclerosis characterized by a progressive deterioration in neurologic function which is in contrast to the more typical relapsing remitting form. If the clinical course is free of distinct remissions, it is referred to as primary progressive multiple sclerosis. When the progressive decline is punctuated by acute exacerbations, it is referred to as progressive relapsing multiple sclerosis. The term secondary progressive multiple sclerosis is used when relapsing remitting multiple sclerosis evolves into the chronic progressive form. (From Ann Neurol 1994;36 Suppl:S73-S79; Adams et al., Principles of Neurology, 6th ed, pp903-914)
Fibrinogens which have a functional defect as the result of one or more amino acid substitutions in the amino acid sequence of normal fibrinogen. Abnormalities of the fibrinogen molecule may impair any of the major steps involved in the conversion of fibrinogen into stabilized fibrin, such as cleavage of the fibrinopeptides by thrombin, polymerization and cross-linking of fibrin. The resulting dysfibrinogenemias can be clinically silent or can be associated with bleeding, thrombosis or defective wound healing.
Vaccines or candidate vaccines used to prevent EBOLA HEMORRHAGIC FEVER.
Order of mammals whose members are adapted for flight. It includes bats, flying foxes, and fruit bats.
A phylum of ARCHAEA comprising at least seven classes: Methanobacteria, Methanococci, Halobacteria (extreme halophiles), Archaeoglobi (sulfate-reducing species), Methanopyri, and the thermophiles: Thermoplasmata, and Thermococci.
Geological formations consisting of underground enclosures with access from the surface.
A species of ARENAVIRUS, part of the Old World Arenaviruses (ARENAVIRUSES, OLD WORLD), and the etiologic agent of LASSA FEVER. LASSA VIRUS is a common infective agent in humans in West Africa. Its natural host is the multimammate mouse Mastomys natalensis.
Semi-synthetic complex derived from nucleic-acid free viral particles. They are essentially reconstituted viral coats, where the infectious nucleocapsid is replaced by a compound of choice. Virosomes retain their fusogenic activity and thus deliver the incorporated compound (antigens, drugs, genes) inside the target cell. They can be used for vaccines (VACCINES, VIROSOME), drug delivery, or gene transfer.
A family of bullet-shaped viruses of the order MONONEGAVIRALES, infecting vertebrates, arthropods, protozoa, and plants. Genera include VESICULOVIRUS; LYSSAVIRUS; EPHEMEROVIRUS; NOVIRHABDOVIRUS; Cytorhabdovirus; and Nucleorhabdovirus.
A species of gram-positive bacteria that is a common soil and water saprophyte.
A CELL LINE derived from the kidney of the African green (vervet) monkey, (CERCOPITHECUS AETHIOPS) used primarily in virus replication studies and plaque assays.
A family of RNA viruses naturally infecting rodents and consisting of one genus (ARENAVIRUS) with two groups: Old World Arenaviruses (ARENAVIRUSES, OLD WORLD) and New World Arenaviruses (ARENAVIRUSES, NEW WORLD). Infection in rodents is persistent and silent. Vertical transmission is through milk-, saliva-, or urine-borne routes. Horizontal transmission to humans, monkeys, and other animals is important.
An acute febrile human disease caused by the LASSA VIRUS.
A species of CERCOPITHECUS containing three subspecies: C. tantalus, C. pygerythrus, and C. sabeus. They are found in the forests and savannah of Africa. The African green monkey (C. pygerythrus) is the natural host of SIMIAN IMMUNODEFICIENCY VIRUS and is used in AIDS research.
Those customs and ceremonies pertaining to the dead.
A broad category of viral proteins that play indirect roles in the biological processes and activities of viruses. Included here are proteins that either regulate the expression of viral genes or are involved in modifying host cell functions. Many of the proteins in this category serve multiple functions.
Proteins conjugated with nucleic acids.
Proteins associated with the inner surface of the lipid bilayer of the viral envelope. These proteins have been implicated in control of viral transcription and may possibly serve as the "glue" that binds the nucleocapsid to the appropriate membrane site during viral budding from the host cell.
Release of a virus from the host cell following VIRUS ASSEMBLY and maturation. Egress can occur by host cell lysis, EXOCYTOSIS, or budding through the plasma membrane.
Equipment used to prevent contamination of and by patients, especially those with bacterial infections. This includes plastic surgical isolators and isolators used to protect immunocompromised patients.
An experimental animal model for central nervous system demyelinating disease. Inoculation with a white matter emulsion combined with FREUND'S ADJUVANT, myelin basic protein, or purified central myelin triggers a T cell-mediated immune response directed towards central myelin. The pathologic features are similar to MULTIPLE SCLEROSIS, including perivascular and periventricular foci of inflammation and demyelination. Subpial demyelination underlying meningeal infiltrations also occurs, which is also a feature of ENCEPHALOMYELITIS, ACUTE DISSEMINATED. Passive immunization with T-cells from an afflicted animal to a normal animal also induces this condition. (From Immunol Res 1998;17(1-2):217-27; Raine CS, Textbook of Neuropathology, 2nd ed, p604-5)
A genus of the family RHABDOVIRIDAE that infects a wide range of vertebrates and invertebrates. The type species is VESICULAR STOMATITIS INDIANA VIRUS.
A subfamily of the Old World monkeys, CERCOPITHECIDAE. They inhabit the forests and savannas of Africa. This subfamily contains the following genera: CERCOCEBUS; CERCOPITHECUS; ERYTHROCEBUS; MACACA; PAPIO; and THEROPITHECUS.
Animate or inanimate sources which normally harbor disease-causing organisms and thus serve as potential sources of disease outbreaks. Reservoirs are distinguished from vectors (DISEASE VECTORS) and carriers, which are agents of disease transmission rather than continuing sources of potential disease outbreaks.
A rapid onset form of SYSTEMIC SCLERODERMA with progressive widespread SKIN thickening over the arms, the legs and the trunk, resulting in stiffness and disability.
Diseases characterized by loss or dysfunction of myelin in the central or peripheral nervous system.
A rare central nervous system demyelinating condition affecting children and young adults. Pathologic findings include a large, sharply defined, asymmetric focus of myelin destruction that may involve an entire lobe or cerebral hemisphere. The clinical course tends to be progressive and includes dementia, cortical blindness, cortical deafness, spastic hemiplegia, and pseudobulbar palsy. Concentric sclerosis of Balo is differentiated from diffuse cerebral sclerosis of Schilder by the pathologic finding of alternating bands of destruction and preservation of myelin in concentric rings. Alpers' Syndrome refers to a heterogeneous group of diseases that feature progressive cerebral deterioration and liver disease. (From Adams et al., Principles of Neurology, 6th ed, p914; Dev Neurosci 1991;13(4-5):267-73)
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
Sudden increase in the incidence of a disease. The concept includes EPIDEMICS and PANDEMICS.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Layers of protein which surround the capsid in animal viruses with tubular nucleocapsids. The envelope consists of an inner layer of lipids and virus specified proteins also called membrane or matrix proteins. The outer layer consists of one or more types of morphological subunits called peplomers which project from the viral envelope; this layer always consists of glycoproteins.
Proteins found in any species of virus.
The entering of cells by viruses following VIRUS ATTACHMENT. This is achieved by ENDOCYTOSIS, by direct MEMBRANE FUSION of the viral membrane with the CELL MEMBRANE, or by translocation of the whole virus across the cell membrane.
A republic in eastern Africa, south of SUDAN and west of KENYA. Its capital is Kampala.
A cylindrical column of tissue that lies within the vertebral canal. It is composed of WHITE MATTER and GRAY MATTER.
Six-carbon saturated hydrocarbon group of the methane series. Include isomers and derivatives. Various polyneuropathies are caused by hexane poisoning.
Suspensions of attenuated or killed viruses administered for the prevention or treatment of infectious viral disease.
Inflammation of the optic nerve. Commonly associated conditions include autoimmune disorders such as MULTIPLE SCLEROSIS, infections, and granulomatous diseases. Clinical features include retro-orbital pain that is aggravated by eye movement, loss of color vision, and contrast sensitivity that may progress to severe visual loss, an afferent pupillary defect (Marcus-Gunn pupil), and in some instances optic disc hyperemia and swelling. Inflammation may occur in the portion of the nerve within the globe (neuropapillitis or anterior optic neuritis) or the portion behind the globe (retrobulbar neuritis or posterior optic neuritis).
The least progressive form of SYSTEMIC SCLERODERMA with skin thickening restricted to the face, neck and areas distal to the elbows and/or knees, sparing the trunk. The CREST SYNDROME is a form of limited scleroderma.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Identification of those persons (or animals) who have had such an association with an infected person, animal, or contaminated environment as to have had the opportunity to acquire the infection. Contact tracing is a generally accepted method for the control of sexually transmitted diseases.
Viral proteins found in either the NUCLEOCAPSID or the viral core (VIRAL CORE PROTEINS).
An abundant cytosolic protein that plays a critical role in the structure of multilamellar myelin. Myelin basic protein binds to the cytosolic sides of myelin cell membranes and causes a tight adhesion between opposing cell membranes.
A species of the genus MACACA which typically lives near the coast in tidal creeks and mangrove swamps primarily on the islands of the Malay peninsula.
An area showing altered staining behavior in the nucleus or cytoplasm of a virus-infected cell. Some inclusion bodies represent "virus factories" in which viral nucleic acid or protein is being synthesized; others are merely artifacts of fixation and staining. One example, Negri bodies, are found in the cytoplasm or processes of nerve cells in animals that have died from rabies.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Diseases characterized by a selective degeneration of the motor neurons of the spinal cord, brainstem, or motor cortex. Clinical subtypes are distinguished by the major site of degeneration. In AMYOTROPHIC LATERAL SCLEROSIS there is involvement of upper, lower, and brainstem motor neurons. In progressive muscular atrophy and related syndromes (see MUSCULAR ATROPHY, SPINAL) the motor neurons in the spinal cord are primarily affected. With progressive bulbar palsy (BULBAR PALSY, PROGRESSIVE), the initial degeneration occurs in the brainstem. In primary lateral sclerosis, the cortical neurons are affected in isolation. (Adams et al., Principles of Neurology, 6th ed, p1089)
A protein-nucleic acid complex which forms part or all of a virion. It consists of a CAPSID plus enclosed nucleic acid. Depending on the virus, the nucleocapsid may correspond to a naked core or be surrounded by a membranous envelope.
An oxidoreductase that catalyzes the reaction between superoxide anions and hydrogen to yield molecular oxygen and hydrogen peroxide. The enzyme protects the cell against dangerous levels of superoxide. EC 1.15.1.1.
Multiple protein bands serving as markers of specific ANTIBODIES and detected by ELECTROPHORESIS of CEREBROSPINAL FLUID or serum. The bands are most often seen during inflammatory or immune processes and are found in most patients with MULTIPLE SCLEROSIS.
One of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA. It is a cytokine with antiviral, antiproliferative, and immunomodulating activity.
Ribonucleic acid that makes up the genetic material of viruses.
The lipid-rich sheath surrounding AXONS in both the CENTRAL NERVOUS SYSTEMS and PERIPHERAL NERVOUS SYSTEM. The myelin sheath is an electrical insulator and allows faster and more energetically efficient conduction of impulses. The sheath is formed by the cell membranes of glial cells (SCHWANN CELLS in the peripheral and OLIGODENDROGLIA in the central nervous system). Deterioration of the sheath in DEMYELINATING DISEASES is a serious clinical problem.
In a rare, severe from of MS known as Marburg's syndrome, the citrullination was even more extensive. Interest in MBP has ... A "molecular mimicry" hypothesis of multiple sclerosis has been suggested, in which T cells are, in essence, confusing MBP with ... Notably, MBP isolated from individuals with multiple sclerosis have had a higher degree of citrullination and a smaller ... July 2003). "Antimyelin antibodies as a predictor of clinically definite multiple sclerosis after a first demyelinating event ...
"Marburg type and Balò's concentric sclerosis: rare and acute variants of multiple sclerosis". Neurol. Sci. 25 (Suppl 4): S361-3 ... Schilder's diffuse sclerosis) மற்றும் மார்பர்க் மல்டிபிள் ஸ்களீரோசிஸ் (Marburg multiple sclerosis) என்பனவாம்.[13][14] ... National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis". Neurology ... 7.0 7.1 7.2 7.3 7.4 7.5 7.6 7.7 7.8 Lublin FD, Reingold SC (April 1996). "Defining the clinical course of multiple sclerosis: ...
... while suffering from Marburg variety of Multiple sclerosis. In season 3, episode 9 of The Good Fight, the character Brenda ... multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), PANDAS in children and adults, and Parkinson's disease (PD). It ... Recent studies suggest that approximately 10% of patients with multiple sclerosis (MS) will experience at least one episode of ... A study designed specifically to survey for prevalence found that 49% of patients with amyotrophic lateral sclerosis (ALS) also ...
Marburg multiple sclerosis, an aggressive form, also known as malignant, fulminant or acute MS. Tumefactive Multiple sclerosis ... Multiple sclerosis and other demyelinating diseases of the central nervous system (CNS) produce lesions (demyelinated areas in ... He said: The specific brain plaques of multiple sclerosis can only be caused by energetic venous back-jets set in motion by ... "Dawson's fingers" is the name for the lesions around the ventricle-based brain veins of patients with multiple sclerosis and ...
Sir Patrick Manson Marburg multiple sclerosis - Otto Marburg Marfan syndrome - Antoine Marfan Marshall syndrome - Richard E. ... was not the first patient described as having amyotrophic lateral sclerosis, the association of such a prominent individual ... M Gerold Balo concentric sclerosis (a.k.a. Balo disease) - József Mátyás Baló Bamberger disease - Heinrich von Bamberger ...
In 1881 he became a professor of pathological anatomy in Giessen, and two years later garnered the same position at Marburg. In ... In 1904 Marchand is credited with coining the term atherosclerosis from the Greek "athero", meaning gruel, and "sclerosis", ...
... the disease caused by Marburg virus Marburg multiple sclerosis, malignant form of multiple sclerosis Other Marburg Colloquy, a ... Marburg is a town in Hesse, Germany. Marburg may also refer to: Places Marburger Schloss, a castle in Marburg, Germany ... South Africa Marburg, Queensland, Australia Marburg (Virginia), a historic home in Richmond, Virginia People Konrad von Marburg ... University of Marburg, the principal university in the city of Marburg, Germany Maribor, Slovenia (also known as Marburg an der ...
Balo concentric sclerosis, Schilder's diffuse sclerosis, and Marburg multiple sclerosis. There is debate on whether they are MS ... List of multiple sclerosis organizations List of people with multiple sclerosis "NINDS Multiple Sclerosis Information Page". ... National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis". Neurology ... National Multiple Sclerosis Society. "Changes in multiple sclerosis disease-course (or "type") descriptions" (PDF). Archived ( ...
Marburg multiple sclerosis) has been named after him. Marburg died of cancer in New York in 1948, at the age of 74. Otto ... Marburg was not associated with the Marburg virus, which was discovered in 1967 in the German town of Marburg. O. Marburg: ... O. Marburg: Der Kopfschmerz und seine Behandlung. Moritz Perles, Vienna 1926 - Headache and its treatment. O. Marburg: Der ... O. Marburg, M. Helfand: Injuries of the nervous system, including poisonings. Veritas Press, New York 1939 - O. Marburg: ...
In 1909 he relocated to the University of Marburg as an associate professor and director of the medical polyclinic. In 1921 he ... Die multiple Sklerose des Gehirns und Rückenmarks, ihre Pathologie und Behandlung, 1904 - Multiple sclerosis of the brain and ... Eduard Müller (4 January 1876, in Annweiler am Trifels - 30 December 1928, in Marburg) was a German internist and neurologist. ...
Later, it was found that some cases of MS were presenting anti-MOG autoantibodies, mainly overlapping with the Marburg variant ... "Myelocortical multiple sclerosis: a subgroup of multiple sclerosis patients with spinal cord and cortical demyelination". ... In 1996, the US National Multiple Sclerosis Society (NMSS) Advisory Committee on Clinical Trials in Multiple Sclerosis (ACCTMS ... cardiac arrythmia Mayo Clinic: Multiple Sclerosis "FDA approves new oral treatment for multiple sclerosis". fda.gov. Retrieved ...
Schilder's diffuse sclerosis, and Marburg multiple sclerosis. There is debate on whether they are MS variants or different ... National Multiple Sclerosis Society. "Changes in multiple sclerosis disease-course (or "type") descriptions" (PDF). Archived ( ... Multiple sclerosis diagnosis can only be made when there is proof of lesions disseminated in time and in space. Therefore, when ... Multiple sclerosis is typically diagnosed based on the presenting signs and symptoms, in combination with supporting medical ...
Balo concentric sclerosis and Marburg multiple sclerosis. Symptoms are similar to those in multiple sclerosis and may include ... Myelinoclastic diffuse sclerosis (Schilder's disease) is immunologically distinct from multiple sclerosis: results from ... Diffuse myelinoclastic sclerosis, sometimes referred to as Schilder's disease, is a very infrequent neurodegenerative disease ... Afifi AK, Bell WE, Menezes AH, Moore SA (1994). "Myelinoclastic diffuse sclerosis (Schilder's disease): report of a case and ...
Idiopathic inflammatory demyelinating diseases Malignant multiple sclerosis Marburg acute multiple sclerosis Xia L., Lin S., ... National Multiple Sclerosis Society. "Epidemiology of MS". Retrieved 2012-11-17. Lattanzi S (2012). "Solitary sclerosis: ... Approximately 2 million people in the world suffer from multiple sclerosis Tumefactive multiple sclerosis cases make up 1 to 2 ... it is accepted that the two main causes of pseudo-tumoral lesions are Marburg multiple sclerosis and acute disseminated ...
Scientists used to believe that the prognosis was similar to Marburg multiple sclerosis, but now they know that patients can ... Baló's concentric sclerosis is a demyelinating disease similar to standard multiple sclerosis, but with the particularity that ... 2015). "Balo's Concentric Sclerosis with Acute Presentation and Co-Existing Multiple Sclerosis-Typical Lesions on MRI". Case ... 7 Tesla MRI of Balo's concentric sclerosis versus multiple sclerosis lesions, Annals of clinical and tranlational neurology, 29 ...
... , also known as Marburg multiple sclerosis or acute fulminant multiple sclerosis, is considered ... "Marburg type and Balò's concentric sclerosis: rare and acute variants of multiple sclerosis". Neurol. Sci. 25 (Suppl): S361-3. ... Sometimes Marburg MS is considered a synonym for tumefactive MS, but not for all authors.[citation needed] Marburg MS has been ... It took its name from Otto Marburg. It can be diagnosed in vivo with an MRI scan. If Marburg disease occurs in the form of a ...
Final Diagnosis: Marburg multiple sclerosis; malnutrition; Rhodococcus Absent: Olivia Wilde as Remy "Thirteen" Hadley. ...
... and Marburg multiple sclerosis. There is debate on whether they are MS variants or different diseases.[63] Multiple sclerosis ... List of people with multiple sclerosis. References. *^ a b c d e f g h "NINDS Multiple Sclerosis Information Page". National ... Main article: Multiple sclerosis research. For the journal formerly known as Multiple Sclerosis, see Multiple Sclerosis Journal ... National Multiple Sclerosis Society. "Changes in multiple sclerosis disease-course (or "type") descriptions" (PDF). Archived ( ...
Balo concentric sclerosis. *Neuromyelitis optica. *Marburg multiple sclerosis. *Schilder's disease. *Tumefactive multiple ... Bruce D Trapp et al., Myelocortical multiple sclerosis: a subgroup of multiple sclerosis patients with spinal cord and cortical ... Paul M. Matthews, Decade in review-multiple sclerosis: New drugs and personalized medicine for multiple sclerosis, Nature ... "A pilot trial of low-dose naltrexone in primary progressive multiple sclerosis". Multiple Sclerosis. 14 (8): 1076-83. doi: ...
Balo concentric sclerosis. *Marburg acute multiple sclerosis. *Neuromyelitis optica. *Diffuse myelinoclastic sclerosis ... Minegar, Alireza (2003). "Blood-Brain Barrier Disruption in Multiple Sclerosis". Multiple Sclerosis Journal. Sage Journals. 9 ( ... See also: Multiple sclerosis § Medications, and Management of multiple sclerosis. Treatments are patient-specific and depend on ... Rosati G (April 2001). "The prevalence of multiple sclerosis in the world: an update". Neurol. Sci. 22 (2): 117-39. doi:10.1007 ...
Balo concentric sclerosis. *Marburg acute multiple sclerosis. *Neuromyelitis optica. *Diffuse myelinoclastic sclerosis ... "FDA approves new oral treatment for multiple sclerosis". U.S. Food and Drug Administration (FDA). 29 March 2019. Retrieved 4 ... Multiple Sclerosis (Houndmills, Basingstoke, England). 24 (12): 1594-1604. doi:10.1177/1352458517727603. PMID 28870107. S2CID ... Multiple sclerosis[edit]. In the mid-1990s Beutler, in collaboration with Jack Sipe, a neurologist at Scripps, ran several ...
Balo concentric sclerosis, Schilder's diffuse sclerosis, and Marburg multiple sclerosis. There is debate on whether they are MS ... Main article: Multiple sclerosis research. For the journal formerly known as Multiple Sclerosis, see Multiple Sclerosis Journal ... National Multiple Sclerosis Society. "Changes in multiple sclerosis disease-course (or "type") descriptions" (PDF). Archived ( ... National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis". Neurology ...
Elected mayor of 2016, Paul Pisasale, resigned on 6 June 2017 citing health concerns (specifically multiple sclerosis). ... Marburg, Rosewood, South Ripley, Walloon, and Willowbank. Nerima City, Japan (from 1994) Hyderabad, India (from 2010) "3218.0 ...
BCX4430 is protective against Ebola and Marburg viruses. Such adenosine analogs are potentially clinically useful since they ... multiple sclerosis, and cancers of the central nervous system. Adenosine is an endogenous agonist of the ghrelin/growth hormone ...
Multiple v Multiple sclerosis ichthyosis factor VIII deficiency Multiple sclerosis Multiple subcutaneous angiolipomas Multiple ... genetic types Mannosidosis Manouvrier syndrome Mansonelliasis Mantle cell lymphoma Marashi-Gorlin syndrome Marburg fever ... Meretoja syndrome Merkle tumors Merlob-Grunebaum-Reisner syndrome Merlob syndrome Mesangial sclerosis, diffuse Mesenteric ...
Balo concentric sclerosis. *Neuromyelitis optica. *Marburg multiple sclerosis. *Schilder's disease. *Tumefactive multiple ... Multiple sclerosis and other demyelinating diseases of CNS (G35-G37, 340-341) ...
Marburg virus, first discovered in 1967, attracted widespread press attention in April 2005 for an outbreak in Angola. Ebola ... and neurological diseases such as multiple sclerosis and chronic fatigue syndrome. There is controversy over whether the ...
... nodular sclerosis, grade 1 Classical Hodgkin lymphoma, nodular sclerosis grade 1 Hodgkin disease, nodular sclerosis, lymphocyte ... malignancies only at National Cancer Institute Overview at University hospital Gießen und Marburg Download table German version ... nodular sclerosis, grade 2 Classical Hodgkin lymphoma, nodular sclerosis, grade 2 Hodgkin disease, nodular sclerosis, ... nodular sclerosis, NOS M9664/3 Hodgkin lymphoma, nodular sclerosis, cellular phase Classical Hodgkin lymphoma, nodular ...
William Walker Rockwell, Die Doppelehe des Landgrafen Philipp von Hessen (Marburg, 1904), p. 280, n. 2 (copy at Google Books), ... Poser, Charles M. (1994). "The dissemination of multiple sclerosis: A Viking saga? A historical essay". Annals of Neurology. 36 ...
"A pilot trial of low-dose naltrexone in primary progressive multiple sclerosis.". Multiple Sclerosis 14 (8): 1076-83. PMID ... Akutni diseminirani encefalitis • Baloova koncentrična skleroza • Devicova bolest • Gijen-Bareov sindrom • Marburg multipla ... interferon beta-1a in early multiple sclerosis". N Engl J Med. 359 (17): 1786-801. PMID 18946064. doi:10.1056/NEJMoa0802670. ... 2006). "Oral fingolimod (FTY720) for relapsing multiple sclerosis". N. Engl. J. Med. 355 (11): 1124-40. PMID 16971719. doi: ...
Marburger Rede (Marburg Speech) - a speech made on 17 June 1934 by Franz von Papen at the University of Marburg, during which, ... The film's protagonist is a man facing a decision to kill his terminally ill wife who is suffering from multiple sclerosis and ...
Marburg virus, first discovered in 1967, attracted widespread press attention in April 2005 for an outbreak in Angola.[174] ... and neurological diseases such as multiple sclerosis and chronic fatigue syndrome.[147] There is controversy over whether the ...
2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 2.12 Compston A, Coles A (April 2002). "Multiple sclerosis". Lancet ... Sklerosisi inayosambaa ya Schilder na Sklerosisi ya sehemu nyingi ya Marburg. Kuna mjadala kuhusu iwapo ni aina za sklerosisi ... 9.00 9.01 9.02 9.03 9.04 9.05 9.06 9.07 9.08 9.09 9.10 9.11 9.12 Milo R, Kahana E (March 2010). "Multiple sclerosis: ... 98.0 98.1 98.2 98.3 98.4 98.5 98.6 Miller AE (2011). "Multiple sclerosis: where will we be in 2020?". Mt. Sinai J. Med. 78 (2 ...
... fulminating multiple sclerosis (MS) (Marburg type) at the pathological and biochemical levels. Postmortem examination of the ... Acute multiple sclerosis (Marburg type) is associated with developmentally immature myelin basic protein Ann Neurol. 1996 Jul; ... We have studied a case of acute, fulminating multiple sclerosis (MS) (Marburg type) at the pathological and biochemical levels ...
Failure to Diagnose Marburg multiple sclerosis including overlooked symptoms and complications for under-diagnosed medical ... As part of Marburg multiple sclerosis diagnosis, consider whether any of these Marburg multiple sclerosis complications may ... to correctly diagnose Marburg multiple sclerosis leading to a person remaining with undiagnosed Marburg multiple sclerosis. Any ... not necessarily specific to Marburg multiple sclerosis: *Failure to Diagnose *Under-Diagnosed Diseases *How Common is Failure ...
Marburg acute multiple sclerosis, also known as Marburg multiple sclerosis or acute fulminant multiple sclerosis, is considered ... "Marburg type and Balòs concentric sclerosis: rare and acute variants of multiple sclerosis". Neurol. Sci. 25 (Suppl): S361-3. ... Sometimes Marburg MS is considered a synonym for tumefactive MS, but not for all authors.[citation needed] Marburg MS has been ... It took its name from Otto Marburg. It can be diagnosed in vivo with an MRI scan. If Marburg disease occurs in the form of a ...
Marburg Disease. *Meningococcal Infections. *Multiple Sclerosis. *Multiple drug resistant infections. *Obesity or severe ...
Multiple Sclerosis. Multiple Sclerosis, Relapsing-Remitting. Sclerosis. Pathologic Processes. Demyelinating Autoimmune Diseases ... Universitaetsklinikum Marburg; Klinik fuer Neurologie. Marburg, Germany, 35043 Klinikum rechts der Isar der TU Muenchen; ... Secondary progressive multiple sclerosis or history of primary progressive or progressive relapsing MS ... Change from Baseline in Multiple Sclerosis Functional Composite (MSFC) Total Score [ Time Frame: Baseline, Weeks 24, 48, 72, 96 ...
Multiple Sclerosis. Multiple Sclerosis, Relapsing-Remitting. Sclerosis. Pathologic Processes. Demyelinating Autoimmune Diseases ... Efficacy and Safety Study of Oral BG00012 With Active Reference in Relapsing-Remitting Multiple Sclerosis (CONFIRM). The safety ... Relapsing-Remitting Multiple Sclerosis Drug: BG00012 Drug: Placebo Drug: Glatiramer Acetate Phase 3 ... Multiple sclerosis (MS) is a chronic disease of the central nervous system that affects approximately 400,000 persons in North ...
Marburg variant multiple sclerosis - a case report.. Talab R, Kundrata Z. Case Reports 2011; 32(4): 415-420 PubMed PMID: ... Talab R, Kundrata Z. Marburg variant multiple sclerosis - a case report. Neuro Endocrinol Lett. 2011 Jan; 32(4): 415-420 ... Multiple Sclerosis:pathology, Severity of Illness Index, Treatment Failure, Young Adult,. Citation ...
Marburg, Germany, 35043 Novartis Investigative Site. Muenchen, Germany, 80377 Novartis Investigative Site. ... Relapsing multiple sclerosis. Ofatumumab. adult. OMB157. multiple sclerosis. T1 lesions. T2 lesions. relapse. GD-enhancing MRI ... Multiple Sclerosis. Sclerosis. Pathologic Processes. Demyelinating Autoimmune Diseases, CNS. Autoimmune Diseases of the Nervous ... Efficacy and Safety of Ofatumumab Compared to Teriflunomide in Patients With Relapsing Multiple Sclerosis (ASCLEPIOS I). The ...
89: Marburg Virus Disease. 90: Mastoiditis. 91: Measles. 92: Meningitis. 93: Milk Sickness (Tremetol Poisoning). 94: Multiple ... Sclerosis. 95: Mumps. 96: Muscular Dystrophy. 97: Myasthenia Gravis. 98: Nematode Infection. 99: Onchocerciasis. 100: ...
The search for the genetic foundation of multiple sclerosis (MS) severity remains elusive. It is, in fact, controversial ... The search for the genetic foundation of multiple sclerosis (MS) severity remains elusive. It is, in fact, controversial ... Björn Tackenberg, Philipps University of Marburg, Germany. Reviewed by:. Ryan Ramanujam, Karolinska Institute (KI), Sweden. ... Epidemiology of multiple sclerosis. In: Vinken PJ, Bruyn GW, Klawans HL, Koetsier JC, editors. Handbook of Clinical Neurology, ...
Marburg disease. *Measles. *Meningococcal infections. *Motor Neuron Disease (MND). *Multiple sclerosis (MS) ...
2Department of Neurology, Philipps University, Marburg, Germany. 3Max Planck Institute for Molecular Genetics, Berlin, Germany. ... Multiple sclerosis. N. Engl. J. Med. 2000. 343:938-952. View this article via: PubMed CrossRef Google Scholar ... Steinman, L. Multiple sclerosis: a two-stage disease. Nat. Immunol. 2001. 2:762-764. View this article via: PubMed CrossRef ... New concepts in the immunopathogenesis of multiple sclerosis. Nat. Rev. Neurosci. 2002. 3:291-301. View this article via: ...
Fatigue is one of the most disabling side effects in people with multiple sclerosis. While this fact is well known, there has ... Fatigue is one of the most disabling side effects in people with multiple sclerosis (PwMS). While this fact is well known, ... Björn Tackenberg, University of Marburg, Germany. Reviewed by:. Jörg Kraus, Public Hospital Zell am See, Austria. Sven G. Meuth ... A Manual for the Brief Repeatable Battery of Neuropsychological Tests in Multiple Sclerosis. New York: National Multiple ...
Researchers Discover New Antibody Treatment To Protect Against Marburg Virus. The antibodies target a new site on Marburg virus ... Experimental Antibody Drug Protects Nerves from Multiple Sclerosis. An experimental antibody drug aimed at protecting nerves ... that protects against the virus up to 90 to 100 percent, which could lead to treatments for Marburg and Ebola virus. ... from multiple sclerosis offers hope for a new way to combat the neurological disease. ...
Lichen sclerosis ... penis cancer. M. *Marburg virus ... inflammation of the testis, orchititis*Mumps ... prostatitis. N. *Non- ... Multiple Sclerosis ... Impotence*Multiple Sclerosis, Susceptibility To, 1 ... Impotence*Multiple Sclerosis, Susceptibility To, ... Multiple Sclerosis, Susceptibility To, 3 ... Impotence*Multiple Sclerosis, Susceptibility To, 4 ... Impotence*Mumps ... ... Lichen sclerosis ... decreased penis tip sensation, foreskin tightening, painful erections, foreskin scarring, foreskin ...
V. Marburgs Disease. VI. Balòs Concentric Sclerosis. VII. Tumefactive Multiple Sclerosis. Chapter 7 Infectious Diseases I ... I. Multiple Sclerosis. II. Neuromyelitis Optica. II. Acute Disseminated Encephalomyelitis. III. Schilders Disease. ...
The cause of multiple sclerosis (MS) is not known. But scientists believe that a combination of various factors may put an ... Another variant of MS-the Marburg variant-can lead to coma or death within days. ... Multiple Sclerosis (MS). Multiple sclerosis (MS) symptoms vary from person to person, and can last for days to months without ... Multiple Sclerosis (MS). Multiple sclerosis or MS is an autoimmune disorder in which brain and spinal cord nerve cells become ...
20Central Information Office (CIO), Philipps-Universität Marburg, Marburg, Germany. *. 21Institute of Medical Biometry and ... 8Department of Neurology, Philipps-Universität Marburg, Marburg, Germany. *. 9NeuroCure Clinical Research Center, Charité - ... Epidemiology of multiple sclerosis: from risk factors to Prevention-An update. Semin Neurol 2016;36:103-14.doi:10.1055/s-0036- ... Primary infection with the Epstein-Barr virus and risk of multiple sclerosis. Ann Neurol 2010;67:NA-30.doi:10.1002/ana.21978 ...
... collaborations and relationships for DZIF Partner Site Giessen-Marburg-Langen published between 1 April 2019 - 31 March 2020 as ... Some myelin-making cells missing in multiple sclerosis. F. Hoffmann-La Roche AG ... Philipps University of Marburg (Uni Marburg), Germany * Technische Hochschule Mittelhessen University of Applied Sciences (THM ... DZIF Partner Site Giessen-Marburg-Langen Participating institutions DZIF Partner Site Giessen-Marburg-Langen is a research ...
Lymphomatosis cerebri masquerading as the Marburg variant of multiple sclerosis. Publication date: November 2020Source: ... Lauren Strober (Source: Multiple Sclerosis and Related Disorders). Source: Multiple Sclerosis and Related Disorders - September ... Impact of the COVID-19 pandemic on the health care of >1,000 People living with multiple sclerosis: A cross-sectional study. ... Multiple Sclerosis and Related Disorders). Source: Multiple Sclerosis and Related Disorders - October 6, 2020 Category: ...
"Malignant MS" includes individuals who live with advanced MS, aggressive MS, Fulminant MS, or Marburgs Variant MS. ... 11.09 - Neurological - Adult - Multiple Sclerosis, which includes motor problems that interfere with the ability to stand, ...
Demyelinating Disorders 1. Multiple Sclerosis 2. Multiple Sclerosis Variants: Marburgs Disease, Schilders Disease, Balos ... an overview of new pharmacological treatments for multiple sclerosis, and much more! Key Features: Content reflects the core ... Concentric Sclerosis 3. Acute Disseminated Encephalomyelitis 4. Acute Necrotizing Hemorrhagic Encephalomyelitis 5. Central ...
Acute Disseminated Encephalomyelitis, Devics Syndrome, Marburgs Variant of Multiple Sclerosis, Balos Concentric Sclerosis, ... acute disseminated encephalomyelitis; Marburgs variant of MS Balos concentric. sclerosis. - Eligible without biopsy: acute ... necessary - established diagnosis of multiple sclerosis (MS) using Poser criteria;. ...
"Malignant MS" includes individuals who live with advanced MS, aggressive MS, Fulminant MS, or Marburgs Variant MS. ... Why is malignant multiple sclerosis the only form of MS on the list of Compassionate Allowances?. Although multiple sclerosis ... Malignant multiple sclerosis is an aggressive and rare form of MS that causes a rapid decline in functioning. Because of the ... Is multiple sclerosis an approved condition under the Compassionate Allowances Initiative?. Yes, in December 2011, Social ...
... of the brain is useful in the diagnosis and treatment of multiple sclerosis (MS), an inflammatory, demyelinating condition of ... When MS presents in a more fulminant, aggressive manner, it is frequently known as malignant MS or the Marburg variant. ... encoded search term (Brain Imaging in Multiple Sclerosis) and Brain Imaging in Multiple Sclerosis What to Read Next on Medscape ... Brain Imaging in Multiple Sclerosis Updated: Mar 27, 2019 * Author: James A Wilson, MD, MSc, FRCPC; Chief Editor: James G ...
Marburg type, very rare:. *Clinically: Acute onset, rapidly progressive, monophasic (strictly speaking), fatal usually within a ... Tumefactive multiple sclerosis: multiple sclerosis lesions that are large and may mimic brain tumors clinically and on MRI ... In fact, optic neuritis is a common presentation of multiple sclerosis. There are 3-4 other classical multiple sclerosis ... Multiple Sclerosis. December 26, 2015. DiseasesCNS, Immune, Sensory deficit, Visual disturbance, Weaknessteachingneurologist ...
4Central Information Office KKNMS, Philipps University Marburg, 35043 Marburg, Germany.. *. 5Department of Neurology, Klinikum ... 17Clinical Neuroimmunology Group, Department of Neurology, Philipps-University of Marburg, 35043 Marburg, Germany. ... 17Clinical Neuroimmunology Group, Department of Neurology, Philipps-University of Marburg, 35043 Marburg, Germany. ... 17Clinical Neuroimmunology Group, Department of Neurology, Philipps-University of Marburg, 35043 Marburg, Germany. ...
1996). Acute multiple sclerosis (Marburg type) is associated with developmentally immature myelin basic protein. Ann. Neurol. ... Multiple sclerosis (MS) is the most common demyelinating disease of human adults, affecting ∼2 million people worldwide. It is ... Multiple sclerosis (MS) is the most common demyelinating disease of human adults. Its therapies have limited effectiveness in ... Multiple sclerosis (MS) is the most common CNS-demyelinating disease of humans, showing clinical and pathological heterogeneity ...
Beniac DR, Wood DD, Palaniyar N, Ottensmeyer FP, Moscarello MA, Harauz G (1999) Marburgs variant of multiple sclerosis ... Wood DD, Bilbao JM, OConnors P, Moscarello MA (1996) Acute multiple sclerosis (Marburg type) is associated with ... Chaudhuri A, Behan PO (2005) Multiple sclerosis: looking beyond autoimmunity. J R Soc Med 98:303-306PubMedGoogle Scholar ... Whitaker JN, Mitchell GW (1996) A possible role for altered myelin basic protein in multiple sclerosis. Ann Neurol 40:3-4PubMed ...
A Case of Rapid Deterioration: Acute Multiple Sclerosis of the Marburg Type ... White, "Human demyelinating disease and the polyomavirus JCV" Multiple Sclerosis, vol.. A review on JC virus infection in ... The prevalence of multiple sclerosis in the north Caucasus region of Turkey: door-to-door epidemiological field study/Multipl ... The Pathophysiology of Demyelination and the Ionic Basis of Nerve Conduction in Multiple Sclerosis: An Overview ...
  • 19 Institute of Neuroimmunology and Multiple Sclerosis and Department of Neurology, University Medical Centre Hamburg-Eppendorf, 20251 Hamburg, Germany. (sciencemag.org)
  • Tehran University of Medical Sciences (TUMS) is accepting applicants with previous experience in Neurology for MULTIPLE SCLEROSIS Fellowship opportunity. (ac.ir)
  • University Hospital Marburg UKGM › Departments › Department of Neurology. (bookinghealth.com)
  • The Department of Neurology at the University Hospital Marburg UKGM, headed by Univ. (bookinghealth.com)
  • Siponimod versus placebo in secondary progressive multiple sclerosis (EXPAND): a double-blind, randomised, phase 3 study. (medscape.com)
  • Meinl E, Krumbholz M, Derfuss T, Junker A, Hohlfeld R. Compartmentalization of inflammation in the CNS: A major mechanism driving progressive multiple sclerosis, J Neurol Sci. (academic.ru)
  • Secondary Progressive Multiple Sclerosis: What is in the Horizon? (jscimedcentral.com)
  • Secondary progressive multiple sclerosis (SPMS) beginning as RRMS, progressive deterioration in neurologic function, unassociated with attacks, eventually ensues (progression may continue or halt). (smartypance.com)
  • Acute hemorrhagic leukoencephalitis, possibly a variant of Acute disseminated encephalomyelitis Balo concentric sclerosis, an unusual presentation of plaques forming concentrenic circles, which can sometimes get better spontaneously. (wikipedia.org)
  • Marburg variant multiple sclerosis - a case report. (nel.edu)
  • Marburg variant multiple sclerosis (also termed "Marburg's Disease") is typified by multiple demyelinating lesions noted deep within the white matter of the brain. (oncologynurseadvisor.com)
  • There are no published studies of Marburg variant multiple sclerosis in children but the published data from adult patients would suggest that a child presenting with variant would have multiple neurological findings and a more severe clinical phenotype. (oncologynurseadvisor.com)
  • Multiple sclerosis (MS) is an immune-mediated inflammatory disease that attacks myelinated axons in the central nervous system, destroying the myelin and the axon in variable degrees and producing significant physical disability within 20-25 years in more than 30% of patients. (medscape.com)
  • generic term for a group of diseases, of unknown cause, in which there is extensive loss of the myelin in the central nervous system, as in multiple sclerosis and Schilder disease. (thefreedictionary.com)
  • தண்டுவட மரப்பு நோய் அல்லது மல்ட்டிபிள் ஸ்களீரோசிஸ் (Multiple sclerosis) (சுருக்கமாக எம்.எஸ், மற்றும் பரவிய ஸ்களீரோசிஸ் அல்லது என்செபலோமையிலடிஸ் டிஸ்ஸேமினாடா எனவும் அழைப்பர்) என்பது மூளை மற்றும் முதுகுத்தண்டை மூடியுள்ள கொழுப்பான மையிலீன் (myelin) உறையில் ஏற்படும் நோயாகும், இந்நோயால் மையிலீன் உறையழிந்தோ , பாதிப்படைந்தோ அல்லது வடுக்களுடனோ பல்வேறு நோய் அறிகுறிகளுடன் காணப்படும். (wikipedia.org)
  • The pattern of extensive post-translational modifications of MBP is dynamic during normal central nervous system (CNS) development and during myelin degeneration in multiple sclerosis (MS), affecting its interactions with the myelin membranes and with other molecules. (springer.com)
  • Bates IR, Libich DS, Wood DD, Moscarello MA, Harauz G (2002) An Arg/Lys→Gln mutant of recombinant murine myelin basic protein as a mimic of the deiminated form implicated in multiple sclerosis. (springer.com)
  • In multiple sclerosis, inflammation in the central nervous system leads to unsheathing of the protective myelin that coats neurons, causing them to degenerate. (photonics.com)
  • New research has demonstrated that an immune response against myelin oligodendrocyte glycoprotein is involved in multiple sclerosis. (photonics.com)
  • Researchers at Heinrich Heine University in Düsseldorf, Philipps University in Marburg and Georg August University in Göttingen, all in Germany, studied the role of antibodies that attack myelin oligodendrocyte glycoprotein, which is embedded in the myelin sheath. (photonics.com)
  • From these findings, the researchers concluded that, in a subgroup of multiple sclerosis patients, antibodies directed against myelin oligodendrocyte glycoprotein caused the neuron damage. (photonics.com)
  • The name multiple sclerosis refers to the multiple scars (or scleroses) on the myelin sheaths. (newworldencyclopedia.org)
  • Multiple sclerosis is a disease in which the myelin (a fatty substance which covers the axon s of nerve cells , important for proper nerve conduction) degenerates. (academic.ru)
  • Multiple Sclerosis (MS) is an inflammatory disorder of the Central Nervous System (CNS) characterised by focal lymphocytic infiltration leading to myelin and axonal damage. (jscimedcentral.com)
  • [ 1 ] The name multiple sclerosis refers to scars (scleroses - better known as plaques or lesions) in the white matter of the brain and spinal cord, which is mainly composed of myelin. (zubiaga.org)
  • Baló's concentric sclerosis (BCS) is a rare demyelinating disease, histopathologically characterized by large concentric lesions with circumferential rings of myelin loss alternating with rings of myelin preservation. (biomedcentral.com)
  • Multiple Sclerosis (MS) is a chronic inflammatory disease of the central nervous system, in which the immune cells attack the insulating myelin sheath surrounding nerve fibers. (xonl.de)
  • We conclude that the possible etiologies of demyelination include viral and/or immune-mediated factors similar to those seen in other demyelinating diseases , such as multiple sclerosis and Guillain-Barre syndrome. (thefreedictionary.com)
  • Balo's concentric sclerosis is a rare multiple sclerosis variant notable for the appearance of rings of demyelination within the visualized lesions of the affected brain. (oncologynurseadvisor.com)
  • Devic's neuromyelitis optica may represent the prototypical disease with antibody/complement-mediated demyelination, whereas cases with Balò's concentric sclerosis show oligodendrocyte dystrophy. (springer.com)
  • The role of IL-33 in inflammatory CNS diseases such as multiple sclerosis (MS) is of particular interest as MS is a disease characterised by immune-mediated demyelination of axons, thus IL-33 has the potential to modulate both the immune and the CNS system and therefore to influence disease pathology. (biomedcentral.com)
  • We present a case of Multiple Sclerosis where the presenting symptom was hemifacial spasm thought to be due to a central area of demyelination. (jscimedcentral.com)
  • Multiple sclerosis (abbreviated MS, also known as disseminated sclerosis or encephalomyelitis disseminata ) is an autoimmune condition in which the immune system attacks the central nervous system , leading to demyelination . (zubiaga.org)
  • In CIS, a patient has an attack suggestive of demyelination , but does not fulfill the criteria for multiple sclerosis. (zubiaga.org)
  • Other diseases in this group are neuromyelitis optica (NMO), Balo concentric sclerosis, and Schilder's disease. (wikipedia.org)
  • These can include (depending on what you read) Marburg MS, Schilder's diffuse sclerosis, Balo concentric sclerosis and Devic's disease. (howstuffworks.com)
  • If Marburg disease occurs in the form of a single large lesion, it can be radiologically indistinguishable from a brain tumor or abscess. (wikipedia.org)
  • Multiple sclerosis (MS) is a chronic disease of the central nervous system that affects approximately 400,000 persons in North America and 365,000 persons in Europe. (clinicaltrials.gov)
  • 89: Marburg Virus Disease. (cengage.com)
  • An experimental antibody drug aimed at protecting nerves from multiple sclerosis offers hope for a new way to combat the neurological disease. (medindia.net)
  • Multiple Sclerosis Variants: Marburg's Disease, Schilder's Disease, Balo's Concentric Sclerosis 3. (whsmith.co.uk)
  • Axial diffusion-weighted MRI in a patient with multiple sclerosis shows several hyperintense lesions, a feature of inflammatory disease activity. (medscape.com)
  • Therefore, multiple sclerosis is typically a relapsing-remitting disease with patients having multiple episodes of neurological dysfunction that get better and then recur. (learningneurology.com)
  • Even with modern MRI and clinical criteria for multiple sclerosis, not uncommonly patients may need to be observed to see if the disease evolves over time. (learningneurology.com)
  • Please note that neuromyelitis optica (Devic's disease) was formerly considred to be a variant of multiple sclerosis, but is now established as a separate condition: Devic's disease: , optic neuritis in both eyes & transverse myelitis. (learningneurology.com)
  • Multiple sclerosis (MS) is the most common CNS-demyelinating disease of humans, showing clinical and pathological heterogeneity and a general resistance to therapy. (biologists.org)
  • Multiple sclerosis (MS) is the most common demyelinating disease of human adults. (biologists.org)
  • White, "Human demyelinating disease and the polyomavirus JCV"' Multiple Sclerosis, vol. (thefreedictionary.com)
  • This mechanism could be operative in demyelinating diseases such as chronical multiple sclerosis (MS), and fulminating MS (Marburg disease). (abcam.com)
  • Balo's concentric multiple sclerosis disease has a benign course described in the few published studies of longitudinal follow-up in children. (oncologynurseadvisor.com)
  • Laboratory studies are typically unrevealing and not specific to this disease, and the diagnosis is based on clinical appearance (typically more severe than typical multiple sclerosis) and (possibly serial) radiological findings. (oncologynurseadvisor.com)
  • Schilder's disease also referred to as "myelinclastic diffuse sclerosis" or merely "diffuse sclerosis" is a benign multiple sclerosis variant seen in children discussed in its own chapter. (oncologynurseadvisor.com)
  • Death usually results from secondary complications (50-66%), such as pulmonary or renal causes, but can also be due to primary complications, suicide, and causes unrelated to MS. The Marburg variant of MS is an acute and clinically fulminant form of the disease that can lead to coma or death within days. (medscape.com)
  • Multiple sclerosis (MS) is a chronic, inflammatory , noninfectious disease that affects the central nervous system (CNS). (newworldencyclopedia.org)
  • Summary: Baló's concentric sclerosis (BCS) is a rare demyelinating disease considered to be a variant of multiple sclerosis. (ajnr.org)
  • Multiple sclerosis (abbreviated MS , formerly known as disseminated sclerosis or encephalomyelitis disseminata ) is a chronic , inflammatory , demyelinating disease that affects the central nervous system (CNS) . (bionity.com)
  • Recent research findings have provided convincing evidence indicating a role for Interleukin-33 (IL-33) signalling pathway in a number of central nervous system (CNS) diseases including multiple sclerosis (MS) and Alzheimer's disease. (biomedcentral.com)
  • He is deputy spokesman for the Disease-oriented Competence Network for Multiple Sclerosis and is a member of the medical board of the German Multiple Sclerosis Society. (tum.de)
  • Multiple Sclerosis (MS) is the most common demyelinating disease of the CNS and the second most common cause of disability among young adults. (pdfmedfinder.com)
  • Recognize common and unusual presentations and manifestations of MS, NMO *Generate a differential diagnosis of the broad spectrum of Multiple Sclerosis, its variants, and its mimics *Describe the basic immunopathophysiology of MS *Discuss sensitivities, specificities, and indications for paraclinical and emerging tests that are used to help establish ( or rule out) a diagnosis of MS. *Manage primary and secondary symptoms of MS. *Describe treatment of MS with disease modifying agents. (pdfmedfinder.com)
  • Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system that usually affects young and middle-aged adults and causes a considerable social and economic burden. (ac.ir)
  • Systemic sclerosis (SSc) is an autoimmune disease characterized by microvascular abnormalities, inflammation and fibrosis. (biomedcentral.com)
  • My son has been struggling with Marburg Variant Disease since June of 09, it robbed him of his sight, all ability to do anything for himself. (life-in-spite-of-ms.com)
  • His name is Zac Gilstrap and we started a Marburg Variant Disease page. (life-in-spite-of-ms.com)
  • Now as a group leader at JCSMR, her goal is to combine in vitro findings with in vivo studies using animal models for multiple sclerosis (MS) as well as for inflammatory bowel disease (IBD), bacterial infections and psoriasis. (edu.au)
  • Their research relates to human autoimmune diseases such as multiple sclerosis, psoriasis or inflammatory bowel disease, all of which have been associated to deregulated Th17 cell responses. (edu.au)
  • The damaged areas develop scar tissue which gives the disease its name - multiple areas of scarring or multiple sclerosis. (makingitthroughtherain.com)
  • Multiple Sclerosis or M.S., is a chronic autoimmune disease. (drdechickerand.com)
  • Multiple sclerosis (MS) has been defined as an autoimmune disease of the central nervous system (CNS). (biomedcentral.com)
  • Multiple sclerosis (MS) is a genetically complex disorder, involving many susceptibility loci that probably interact with environmental factors to trigger the disease. (mhmedical.com)
  • Multiple Sclerosis (MS) was recognized as a distinct disease involving both the brain and spinal cord and associated with disseminated demyelinating plaques ("la sclérose en plaques") and axonal damage more than 145 years ago by French neurologist Jean-Martin Charcot [1]. (jscimedcentral.com)
  • Multiple sclerosis (MS) is a chronic inflammatory, demyelinating and degenerative disease of the central nervous system. (jscimedcentral.com)
  • Baló's Concentric Sclerosis (BCS) is a rare heterogeneous demyelinating disease with a variety of phenotypes on Magnetic Resonance Imaging (MRI). (biomedcentral.com)
  • BCS along with tumefactive Multiple Sclerosis (MS), Marburg and Schilder disease are considered types of fulminant demyelinating disorders of the central nervous system (CNS) [ 1 ]. (biomedcentral.com)
  • Multiple sclerosis (MS), also known as disseminated sclerosis or encephalomyelitis disseminata, is an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged. (anatomic.us)
  • We present a 58 years old woman with multiple sclerosis diagnosed in 2007, she was treated with interferon and methylprednisolone with a stable disease until last year. (bvsalud.org)
  • Marburg acute multiple sclerosis, also known as Marburg multiple sclerosis or acute fulminant multiple sclerosis, is considered one of the multiple sclerosis borderline diseases, which is a collection of diseases classified by some as MS variants and by others as different diseases. (wikipedia.org)
  • Multi-centric genetic consortia identified more than 200 multiple sclerosis (MS) susceptibility genes, but validated no gene variants associated with MS severity ( 1 , 2 ). (frontiersin.org)
  • She completed her PhD at the Institute of Medical Microbiology, at Philipps-University in Marburg, Germany. (edu.au)
  • citation needed] Marburg MS has been reported to be closer to anti-MOG associated ADEM than to standard MS It has been reported to appear sometimes post-partum Some anti-MOG cases satisfy the MS requirements (lesions disseminated in time and space) and are therefore traditionally considered MS cases. (wikipedia.org)
  • Coronal fluid-attenuated inversion recovery (FLAIR) MRI in a patient with multiple sclerosis demonstrates periventricular high-signal intensity lesions, which exhibit a typical distribution for multiple sclerosis. (medscape.com)
  • Plain radiographic studies have no positive predictive value in the diagnosis of multiple sclerosis, but occasionally, plain radiographs may be used to exclude mechanical bony lesions. (medscape.com)
  • Multiple sclerosis diagnosis can only be made when there is proof of lesions disseminated in time and in space. (wikipedia.org)
  • As mentioned in the previous section, people with multiple sclerosis have these plaques, or lesions, in the white matter of the brain or spinal cord. (howstuffworks.com)
  • Marburg variant of MS-acute monophasic course typically with large lesions in the cerebral hemispheres 7 ). (neurology.org)
  • Multiple sclerosis and other demyelinating diseases of the central nervous system (CNS) produce lesions (demyelinated areas in the CNS) and glial scars or scleroses. (wikipedia.org)
  • The list of the diseases that produce CNS demyelinating lesions is not complete, but it includes: Standard multiple sclerosis, the most known and extended variant. (wikipedia.org)
  • Marburg multiple sclerosis, an aggressive form, also known as malignant, fulminant or acute MS. Tumefactive Multiple sclerosis: lesions whose size is more than 2 cm, with mass effect, oedema and/or ring enhancement AntiMOG associated encephalomyelitis: Lesions similar to ADEM sometimes and to NMO some others. (wikipedia.org)
  • Multiple sclerosis (MS) is characterized by multiple demyelinated inflammatory lesions disseminated in the central nervous system (CNS). (springer.com)
  • The name multiple sclerosis refers to the scars (scleroses - better known as plaques or lesions) in the white matter. (bionity.com)
  • A rare variant of multiple sclerosis with characteristics of a rapidly progressive, aggressive form of multiple sclerosis with numerous large multifocal demyelinating lesions in deep white matter on cerebral MRI that usually leads to severe disability or death within weeks to months without remission. (cdc.gov)
  • 11] The name multiple sclerosis refers to scars (scleraebetter known as plaques or lesions) in particular in the white matter of the brain and spinal cord. (genetherapy.me)
  • Atypical MS forms, such as Marburg's acute MS, Devic's neuromyelits optica, Balò's concentric sclerosis, and Schilder's diffuse sclerosis share key aspects of MS pathology, however, each of them harbors characteristic discriminative features. (springer.com)
  • Baló's concentric sclerosis followed by MRI and positron emission tomography. (synaps-prod.com)
  • Multiple sclerosis is one of a class of diseases known as autoimmune diseases . (howstuffworks.com)
  • His work focuses on research into B-cells and T-cells in inflammatory diseases of the central nervous system, especially multiple sclerosis (MS). Furthermore, he is investigating genetic factors relevant to the development and treatment of MS. After studying human medicine, Prof. Hemmer obtained his doctorate at the University of Freiburg in 1991. (tum.de)
  • The main focus is placed on the inpatient and outpatient treatment of multiple sclerosis and other inflammatory diseases of the central nervous system. (bookinghealth.com)
  • National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. (medscape.com)
  • The clinical course of BCS was considered similar to that of Marburg's variant of multiple sclerosis, which has a monophasic rapidly progressive course with a fatal outcome (2) . (ajnr.org)
  • In the Journal of Clinical Investigation , researchers led by Magdalena Huber at the University of Marburg in Germany used a mouse model of MS to determine the role of Tc17 cells. (sciencecodex.com)
  • Tehran University of Medical Sciences, as the leading medical university in Iran provides 18 months of advanced training in diagnosis, treatment and clinical research in Multiple Sclerosis. (ac.ir)
  • Hematopoietic stem cell transplantation for multiple sclerosis: is it a clinical reality? (biomedcentral.com)
  • Design, Setting, and Participants Cerebrospinal fluid measurements and clinical data from the observational longitudinal German national multiple sclerosis cohort were analyzed. (jamanetwork.com)
  • Diploma Thesis: 1986 - 1987 "Immunotherapy of experimental autoimmune encephalomyelitis: monoclonal antibodies directed against the Interleukin-2 receptor and Cyclosporin A" at the Max-Planck-Institute, Clinical Research Group for Multiple Sclerosis, Würzburg, Germany, laboratory of Professor Dr. Hartmut Wekerle. (biomedcentral.com)
  • Diagnosis of multiple sclerosis (MS) takes a very long time to diagnose because many times the symptoms stay for a short time, go away, and take several months or years to come back. (medicinenet.com)
  • Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria. (medscape.com)
  • Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. (medscape.com)
  • Malignant multiple sclerosis Tumefactive multiple sclerosis Fontaine, B. (2001). (wikipedia.org)
  • Multiple sclerosis relapses are often unpredictable, occurring without warning and without obvious inciting factors. (zubiaga.org)
  • It took its name from Otto Marburg. (wikipedia.org)
  • Otto Marburg discovered this particular type of MS. There may be one single large lesion that may be mistaken for a tumor or abscess in the brain. (life-in-spite-of-ms.com)
  • Methods Serum samples were collected from 901 patients with a clinically isolated syndrome (CIS) or early relapsing-remitting multiple sclerosis (RRMS) participating in the German National MS cohort, a prospective cohort of patients with early MS with stringent inclusion criteria. (bmj.com)
  • Relapsing-remitting multiple sclerosis (RRMS) (85% MOST COMMON TYPE) episodic flare-ups occurring over days to weeks between periods of neurologic stability. (smartypance.com)
  • The antibodies target a new site on Marburg virus that protects against the virus up to 90 to 100 percent, which could lead to treatments for Marburg and Ebola virus. (medindia.net)
  • They studied the same Ebola virus species currently responsible for an outbreak in West Africa, and also analyzed a related filovirus, Marburg virus, that caused a large outbreak in Angola in 2005 and recently emerged in Uganda. (healthcanal.com)
  • Their results highlight regions in Ebola and Marburg virus RNAs where the polymerase of the virus (a protein that synthesizes the viral RNA) stutters at specific locations, adding extra nucleotides (molecules that form the building blocks of genetic material like DNA and RNA), thereby "editing" the new RNAs. (healthcanal.com)
  • Their work also identified less frequent but similar types of editing events in other Ebola and Marburg virus genes - the first time this has been demonstrated. (healthcanal.com)
  • Because of these messenger RNA modifications, Ebola and Marburg are potentially making proteins "that we previously didn't realize," said Christopher F. Basler, PhD, senior study author and professor of microbiology at Mount Sinai. (healthcanal.com)
  • Pegylated interferon ß-1a for relapsing-remitting multiple sclerosis (ADVANCE): a randomised, phase 3, double-blind study. (medscape.com)
  • Alemtuzumab versus interferon beta 1a as first-line treatment for patients with relapsing-remitting multiple sclerosis: a randomised controlled phase 3 trial. (medscape.com)
  • Findings This cohort study included 673 patients with new diagnoses of relapsing-remitting multiple sclerosis or clinically isolated syndrome. (jamanetwork.com)
  • Tumefactive multiple sclerosis is characterized by a tumor -like lesion larger than two centimeters and signs and symptoms similar to those of a brain tumor. (cdc.gov)
  • To date there have been no controlled treatment studies for tumefactive multiple sclerosis. (cdc.gov)
  • In a small number of cases, people with tumefactive multiple sclerosis have minimal to no symptoms. (cdc.gov)
  • ClinicalTrials.gov lists trials that are related to Tumefactive multiple sclerosis. (cdc.gov)
  • A child with multiple sclerosis, or a clinically isolated syndrome, often will present with solitary or multiple neurological findings, and based on retrospective studies these findings would typically include some combination of weakness, sensory changes, visual changes, and/or cerebellar findings. (oncologynurseadvisor.com)
  • Clinically, patients will resemble others with multiple sclerosis or a clinically isolated syndrome and this diagnosis requires neuroimaging. (oncologynurseadvisor.com)
  • Les formes frontières de sclérose en plaques" [Borderline forms of multiple sclerosis]. (wikipedia.org)
  • Axial T2-weighted MRI in a patient with multiple sclerosis demonstrates numerous white matter plaques in a callosal and pericallosal white matter distribution. (medscape.com)
  • Gray E, Thomas TL, Betmouni S, Scolding N, Love S. Elevated Matrix Metalloproteinase-9 and Degradation of Perineuronal Nets in Cerebrocortical Multiple Sclerosis Plaques. (academic.ru)
  • The graver course is one form of malignant multiple sclerosis, with patients reaching a significant level of disability in less than five years from their first symptoms, often in a matter of months. (wikipedia.org)
  • For patients who survive the acute attack, follow-up treatments include immunosuppression (monthly mitoxantrone or cyclophosphamide) either alone or in combination with IFN beta or GA.[citation needed] Marburg variant of MS is an acute fulminant demyelinating process which in most cases progresses inexorably to death within 1-2 years. (wikipedia.org)
  • Objective To determine the prevalence of antibodies to Epstein-Barr virus (EBV) in a large cohort of patients with early multiple sclerosis (MS). (bmj.com)
  • Opticospinal multiple sclerosis is a multiple sclerosis variant described in Asian populations characterized by a higher proportion of patients with involvement of the optic nerves and the spinal cord. (oncologynurseadvisor.com)
  • What is the life expectancy of patients with multiple sclerosis (MS)? (medscape.com)
  • Their experiments revealed that these antibodies were circulating in some patients suffering from multiple sclerosis, and they found that cultured cells with the protein on their surface died when exposed to the antibodies. (photonics.com)
  • However, I discovered at a recent meeting that quite a number of colleagues are still using the drug in tumefactive and Marburg-variant MS as an induction therapy and they also use it in some patients with highly-active/rapidly-evolving MS in whom they can't use mitoxantrone. (blogspot.com)
  • Marburg patients have a fulminant or malignant course typically over a period of weeks to months. (blogspot.com)
  • A relapsing form of multiple sclerosis is observed in surviving patients. (cdc.gov)
  • Hematopoietic stem cell transplantation (HSCT) is a treatment paradigm that has long been utilized for cancers of the blood and bone marrow but has gained some traction as a treatment paradigm for multiple sclerosis (MS). Success in the treatment of patients with this approach has been reported primarily when strict inclusion criteria are imposed that have eventuated a more precise understanding of MS pathophysiology, thereby governing trial design. (biomedcentral.com)
  • In the past 20 years there have been many notable advances in the treatment of multiple sclerosis (MS). This review provides an overview of the recent advances which have taken place in management of patients with MS, rather than just discussing in detail the findings of various randomized trials of recently approved and/or in process of being approved. (jscimedcentral.com)
  • Question Is intrathecal immunoglobulin synthesis associated with disability worsening in patients with multiple sclerosis? (jamanetwork.com)
  • Dr. Franz Alfons Schelling , on the other hand, is a retired Austrian physician who started in 1973 and spent his entire career studying MS. Interestingly, his investigation began when he noticed enormous differences in the venous outlets in skulls of patients with MS. His online book Multiple Sclerosis - The Image and It's Message - The Meaning of the Classic Lesion Forms ," is a gem. (wordpress.com)
  • Symptoms of multiple sclerosis can range from subtle and mild to disabling and severe. (learningneurology.com)
  • Multiple sclerosis is typically diagnosed based on the presenting signs and symptoms, in combination with supporting medical imaging and laboratory testing. (wikipedia.org)
  • Multiple sclerosis may take several forms, with new symptoms occurring either in discrete attacks (relapsing forms) or slowly accumulating over time (progressive forms). (bionity.com)
  • [1] [2] It is a rare form of multiple sclerosis (MS). Symptoms of tumefactive MS often differ from other MS cases and may include, headaches, changes in thinking, confusion, speech problems, seizures , and weakness. (cdc.gov)
  • Paroxysmal symptoms are common in Multiple Sclerosis. (jscimedcentral.com)
  • Main symptoms of multiple sclerosis. (zubiaga.org)
  • 1]Uhthoff's phenomenon, a worsening of symptoms due to exposure to higher than usual temperatures, and Lhermitte's sign, an electrical sensation that runs down the back when bending the neck, are particularly characteristic of MS.[1] The main measure of disability and severity is the expanded disability status scale (EDSS), with other measures such as the multiple sclerosis functional composite being increasingly used in research. (genetherapy.me)
  • More specifically, the invention relates to using modulators of kallikrein 6 protease activity to treat inflammatory conditions such as multiple sclerosis. (patentsencyclopedia.com)
  • As with other forms of multiple sclerosis, corticosteroids (for example, intravenous methylprednisolone) should be the first line of treatment. (cdc.gov)
  • Although there is no known cause (idiopathic) or cure for multiple sclerosis, there has been a documented, miraculous, total recovery of one sufferer, the nun Rita Klaus, after more than 20 years of MS. All of the "permanent" damage to her central nervous system reverted to normal. (newworldencyclopedia.org)
  • There is no known cure for multiple sclerosis. (anatomic.us)
  • Fatigue is one of the most disabling side effects in people with multiple sclerosis. (frontiersin.org)
  • Fatigue is the most common and disabling symptom experience by people with multiple sclerosis (PwMS). (frontiersin.org)
  • New diagnostic criteria for multiple sclerosis: guidelines for research protocols. (medscape.com)
  • On the other hand, labeling a patient with multiple sclerosis prematurely can have significant negative consequences as well. (learningneurology.com)
  • this finding is characteristic of multiple sclerosis. (medscape.com)
  • The episode, which by definition must last for at least 24 hours, is characteristic of multiple sclerosis but does not yet meet the criteria for a diagnosis of MS because people who experience a CIS may or may not go on to develop MS. (makingitthroughtherain.com)
  • It is also referred to as fulminating multiple sclerosis and malignant multiple sclerosis. (life-in-spite-of-ms.com)
  • Eighty-two asymptomatic SSc, diagnosed according to American College of Rheumatology criteria, aged 43 ± 5 yrs., 62 with diffuse (dSSc) and 20 with localized (lSSc) systemic sclerosis were evaluated by CMR, performed at 1.5 T scanner, according to Lake Louise criteria. (biomedcentral.com)
  • FDA approves new multiple sclerosis treatment: Tecfidera. (medscape.com)
  • Case was evaluated in a medical board, and was considered an atypical Marburg variant of multiple sclerosis. (bvsalud.org)

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