Glycosides formed by the reaction of the hydroxyl group on the anomeric carbon atom of mannose with an alcohol to form an acetal. They include both alpha- and beta-mannosides.
Enzymes that catalyze the transfer of mannose from a nucleoside diphosphate mannose to an acceptor molecule which is frequently another carbohydrate. The group includes EC 2.4.1.32, EC 2.4.1.48, EC 2.4.1.54, and EC 2.4.1.57.
A rapid-growing, nonphotochromogenic species of MYCOBACTERIUM originally isolated from human smegma and found also in soil and water. (From Dorland, 28th ed)
Derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to the hexahydroxy alcohol, myo-inositol. Complete hydrolysis yields 1 mole of glycerol, phosphoric acid, myo-inositol, and 2 moles of fatty acids.
A hexose or fermentable monosaccharide and isomer of glucose from manna, the ash Fraxinus ornus and related plants. (From Grant & Hackh's Chemical Dictionary, 5th ed & Random House Unabridged Dictionary, 2d ed)
An order of gram-positive, primarily aerobic BACTERIA that tend to form branching filaments.
Polysaccharides consisting of mannose units.
A species of gram-positive, aerobic bacteria that produces TUBERCULOSIS in humans, other primates, CATTLE; DOGS; and some other animals which have contact with humans. Growth tends to be in serpentine, cordlike masses in which the bacilli show a parallel orientation.
The bovine variety of the tubercle bacillus. It is called also Mycobacterium tuberculosis var. bovis.
Constituent of 30S subunit prokaryotic ribosomes containing 1600 nucleotides and 21 proteins. 16S rRNA is involved in initiation of polypeptide synthesis.
A genus of gram-positive, aerobic bacteria. Most species are free-living in soil and water, but the major habitat for some is the diseased tissue of warm-blooded hosts.
The outermost layer of a cell in most PLANTS; BACTERIA; FUNGI; and ALGAE. The cell wall is usually a rigid structure that lies external to the CELL MEMBRANE, and provides a protective barrier against physical or chemical agents.
A group of substances similar to VITAMIN K 1 which contains a ring of 2-methyl-1,4-naphthoquinione and an isoprenoid side chain of varying number of isoprene units. In vitamin K 2, each isoprene unit contains a double bond. They are produced by bacteria including the normal intestinal flora.
Any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic moiety such as an acylglycerol (see GLYCERIDES), a sphingoid, a ceramide (CERAMIDES) (N-acylsphingoid) or a prenyl phosphate. (From IUPAC's webpage)
DNA sequences encoding RIBOSOMAL RNA and the segments of DNA separating the individual ribosomal RNA genes, referred to as RIBOSOMAL SPACER DNA.
The presence of bacteria, viruses, and fungi in the soil. This term is not restricted to pathogenic organisms.
The relative amounts of the PURINES and PYRIMIDINES in a nucleic acid.
Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed)
Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. Fatty acids are saturated and unsaturated (FATTY ACIDS, UNSATURATED). (Grant & Hackh's Chemical Dictionary, 5th ed)
The relationships of groups of organisms as reflected by their genetic makeup.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Procedures for identifying types and strains of bacteria. The most frequently employed typing systems are BACTERIOPHAGE TYPING and SEROTYPING as well as bacteriocin typing and biotyping.
Deoxyribonucleic acid that makes up the genetic material of bacteria.
Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides see GLYCEROPHOSPHOLIPIDS) or sphingosine (SPHINGOLIPIDS). They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system.
A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.
The covalent bonding of an alkyl group to an organic compound. It can occur by a simple addition reaction or by substitution of another functional group.
The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
Changing an open-chain hydrocarbon to a closed ring. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
The rotation of linearly polarized light as it passes through various media.
Unsaturated hydrocarbons of the type Cn-H2n, indicated by the suffix -ene. (Grant & Hackh's Chemical Dictionary, 5th ed, p408)
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
A genus of SEA URCHINS in the family Toxopneustidae possessing trigeminate ambulacral plating.
Rare cutaneous eruption characterized by extensive KERATINOCYTE apoptosis resulting in skin detachment with mucosal involvement. It is often provoked by the use of drugs (e.g., antibiotics and anticonvulsants) or associated with PNEUMONIA, MYCOPLASMA. It is considered a continuum of Toxic Epidermal Necrolysis.
Marine, freshwater, or terrestrial mollusks of the class Gastropoda. Most have an enclosing spiral shell, and several genera harbor parasites pathogenic to man.
Somewhat flattened, globular echinoderms, having thin, brittle shells of calcareous plates. They are useful models for studying FERTILIZATION and EMBRYO DEVELOPMENT.
Proteins obtained from species in the class of AMPHIBIANS.
Corneal and conjunctival dryness due to deficient tear production, predominantly in menopausal and post-menopausal women. Filamentary keratitis or erosion of the conjunctival and corneal epithelium may be caused by these disorders. Sensation of the presence of a foreign body in the eye and burning of the eyes may occur.
Sterile solutions that are intended for instillation into the eye. It does not include solutions for cleaning eyeglasses or CONTACT LENS SOLUTIONS.
Exclusive legal rights or privileges applied to inventions, plants, etc.
Colloids formed by the combination of two immiscible liquids such as oil and water. Lipid-in-water emulsions are usually liquid, like milk or lotion. Water-in-lipid emulsions tend to be creams. The formation of emulsions may be aided by amphiphatic molecules that surround one component of the system to form MICELLES.
Cyclic GLUCANS consisting of six (6) glucopyranose units linked by 1,4-glycosidic bonds.
The organ of sight constituting a pair of globular organs made up of a three-layered roughly spherical structure specialized for receiving and responding to light.
Unctuous combustible substances that are liquid or easily liquefiable on warming, and are soluble in ether but insoluble in water. Such substances, depending on their origin, are classified as animal, mineral, or vegetable oils. Depending on their behavior on heating, they are volatile or fixed. (Dorland, 28th ed)
Toxic glycolipids composed of trehalose dimycolate derivatives. They are produced by MYCOBACTERIUM TUBERCULOSIS and other species of MYCOBACTERIUM. They induce cellular dysfunction in animals.
Glycoproteins expressed on cortical thymocytes and on some dendritic cells and B-cells. Their structure is similar to that of MHC Class I and their function has been postulated as similar also. CD1 antigens are highly specific markers for human LANGERHANS CELLS.
An enzyme that catalyzes the conversion of UDP-galactose and N-acylsphingosine to D-galactosylceramide and UDP.
A pattern recognition receptor that forms heterodimers with TLR2 RECEPTOR. The complex interacts with a variety of ligands including LIPOPROTEINS from MYCOPLASMA.
Studies beyond the bachelor's degree at an institution having graduate programs for the purpose of preparing for entrance into a specific field, and obtaining a higher degree.
The teaching staff and members of the administrative staff having academic rank in an educational institution.
Individuals enrolled in a school or formal educational program.
Educational programs for pharmacists who have a bachelor's degree or a Doctor of Pharmacy degree entering a specific field of pharmacy. They may lead to an advanced degree.
The teaching staff and members of the administrative staff having academic rank in a medical school.
Auditory and visual instructional materials.
The educational process of instructing.

Cryptosporidium parvum sporozoite pellicle antigen recognized by a neutralizing monoclonal antibody is a beta-mannosylated glycolipid. (1/146)

The protozoan parasite Cryptosporidium parvum is an important cause of diarrhea in humans, calves, and other mammals worldwide. No approved vaccines or parasite-specific drugs are currently available for the control of cryptosporidiosis. To effectively immunize against C. parvum, identification and characterization of protective antigens are required. We previously identified CPS-500, a conserved, neutralization-sensitive antigen of C. parvum sporozoites and merozoites defined by monoclonal antibody 18.44. In the present study, the biochemical characteristics and subcellular location of CPS-500 were determined. CPS-500 was chloroform extractable and eluted with acetone and methanol in silicic acid chromatography, consistent with being a polar glycolipid. Following chloroform extraction and silicic acid chromatography, CPS-500 was isolated by high-pressure liquid chromatography for glycosyl analysis, which indicated the presence of mannose and inositol. To identify which component of CPS-500 comprised the neutralization-sensitive epitope recognized by 18.44, the ability of the monoclonal antibody to bind CPS-500 treated with proteases, or with alpha- or beta-glycosidases, was determined. Monoclonal antibody 18.44 did not bind antigen treated with beta-D-mannosidase but did bind antigen treated with alpha-D-mannosidase, other alpha- or beta-glycosidases, or a panel of proteases. These data indicated that the target epitope was dependent on terminal beta-D-mannopyranosyl residues. By immunoelectron microscopy, 18.44 binding was localized to the pellicle and an intracytoplasmic tubulovesicular network in sporozoites. Monoclonal antibody 18.44 also bound to antigen deposited and released onto substrate over the course travelled by gliding sporozoites and merozoites. Surface localization, adhesion and release during locomotion, and neutralization sensitivity suggest that CPS-500 may be involved in motility and invasion processes of the infective zoite stages.  (+info)

Determination of the anomeric configurations of Corbicula ceramide di- and trihexoside by chromium trioxide oxidation. (2/146)

The anomeric configurations of Corbicula ceramide dihexoside and ceramide trihexoside were determined by chromium trioxide oxidation and the structures of these lipids were shown to be Man-beta(1 leads to 4)-Glc-beta(1 leads to 1)-ceramide and Man-alpha(1 leads to 4)-Man-beta(1 leads to 4)-Glc-beta(1 leads to 1)-ceramide. These results are compatible with those obtained by enzymic hydrolysis reported previously.  (+info)

Molecular recognition of concanavalin A on mannoside diacetylene lipid monolayer at the air-water interface. (3/146)

The interaction of p-10,12-pentacosadiyne-1-n-phenylamide alpha-D-mannopyranoside (MPDA) with protein concanavalin A (Con A) was studied at the air/water interface. The expansion of molecular area of PDA (10,12-pentacosadiynoic acid)/MPDA mixed monolayer after injection of Con A in subphase shows strong interaction between Con A and the monolayer. The maximum expansion of molecular area decreases as the molar ratio of MPDA increases due to the steric hindrance effect. By using enzyme mannosidase to cut-off the mannoside headgroup of MPDA, expansion of molecular area was greatly reduced, indicating that the binding of Con A is specific to the mannoside headgroup. The kinetics of the binding fits to the first order bimolecular reaction model. Fluorescence quenching of fluorescein isothiocyanate labeled Con A after injection into the subphase gives a direct proof of the molecular recognition.  (+info)

The crystal structures of Man(alpha1-3)Man(alpha1-O)Me and Man(alpha1-6)Man(alpha1-O)Me in complex with concanavalin A. (4/146)

The crystal structures of concanavalin A in complex with Man(alpha1-6)Man(alpha1-O)Me and Man(alpha1-3)Man(alpha1-O)Me were determined at resolutions of 2.0 and 2.8 A, respectively. In both structures, the O-1-linked mannose binds in the conserved monosaccharide-binding site. The O-3-linked mannose of Man(alpha1-3)Man(alpha1-O)Me binds in the hydrophobic subsite formed by Tyr-12, Tyr-100, and Leu-99. The shielding of a hydrophobic surface is consistent with the associated large heat capacity change. The O-6-linked mannose of Man(alpha1-6)Man(alpha1-O)Me binds in the same subsite formed by Tyr-12 and Asp-16 as the reducing mannose of the highly specific trimannose Man(alpha1-3)[Man(alpha1-6)]Man(alpha1-O)Me. However, it is much less tightly bound. Its O-2 hydroxyl makes no hydrogen bond with the conserved water 1. Water 1 is present in all the sugar-containing concanavalin A structures and increases the complementarity between the protein-binding surface and the sugar, but is not necessarily a hydrogen-bonding partner. A water analysis of the carbohydrate-binding site revealed a conserved water molecule replacing O-4 on the alpha1-3-linked arm of the trimannose. No such water is found for the reducing or O-6-linked mannose. Our data indicate that the central mannose of Man(alpha1-3)[Man(alpha1-6)]Man(alpha1-O)Me primarily functions as a hinge between the two outer subsites.  (+info)

The pimB gene of Mycobacterium tuberculosis encodes a mannosyltransferase involved in lipoarabinomannan biosynthesis. (5/146)

The biosynthesis of lipoarabinomannan (LAM), a key mycobacterial lipoglycan that has been implicated in numerous immunoregulatory functions, was examined utilizing D-mannosamine (ManN) as a tool to identify mannosyltransferase genes involved in LAM synthesis. Cell-free reactions utilizing cellular membranes of mycobacteria as the enzyme source indicated that ManN inhibited the synthesis of phosphatidylinositol mannosides, early precursors to LAM. A selection strategy was devised to screen a Mycobacterium tuberculosis genomic library in Mycobacterium smegmatis for clones conferring conditional resistance to ManN, with the rationale that overexpression of the gene(s) encoding a target of ManN would impart a ManN-resistant phenotype under these conditions. This strategy led to the identification of pimB, whose deduced amino acid sequence shows similarity to mannosyltransferases and other glycosyltransferases. Partially purified recombinant PimB protein from Escherichia coli or membranes from M. smegmatis overexpressing the pimB gene were used in cell-free assays to show that PimB catalyzes the formation of triacylphosphatidylinositol dimannoside from GDP-mannose and triacylphosphatidylinositol monomannoside.  (+info)

Biosynthesis of glycosylphosphatidylinositols of Plasmodium falciparum in a cell-free incubation system: inositol acylation is needed for mannosylation of glycosylphosphatidylinositols. (6/146)

The structures of glycosylphosphatidylinositols (GPIs) in Plasmodium have been described [Gerold, Schuppert and Schwarz (1994) J. Biol. Chem. 269, 2597-2606]. A detailed understanding of GPI synthesis in Plasmodium is a prerequisite for identifying differences present in biosynthetic pathways of parasites and host cells. A comparison of the biosynthetic pathway of GPIs has revealed differences between mammalian cells and parasitic protozoans. A cell-free incubation system prepared from asexual erythrocytic stages of Plasmodium falciparum, the causative agent of malaria in humans, is capable of synthesizing the same spectrum of GPIs as that found in metabolically labelled parasites. The formation of mannosylated GPIs in the cell-free system is shown to be inhibited by GTP and, unexpectedly, micromolar concentrations of GDP-Man. Lower concentrations of GDP-Man affect the spectrum of GPIs synthesized. The inositol ring of GPIs of P. falciparum is modified by an acyl group. The preferred donor of this fatty acid at the inositol ring is myristoyl-CoA. Inositol acylation has to precede the mannosylation of GPIs because, in the absence of acyl-CoA or CoA, mannosylated GPIs were not detected. Inositol myristoylation is a unique feature of plasmodial GPIs and thus might provide a potential target for drug therapy.  (+info)

Candida albicans-derived beta-1,2-linked mannooligosaccharides induce desensitization of macrophages. (7/146)

Candida albicans beta-1,2-oligomannosides stimulate macrophage tumor necrosis factor alpha (TNF-alpha) but not NO release. This stimulation desensitized macrophages by altering beta-1, 2-oligomannoside-dependent TNF-alpha production and lipopolysaccharide-dependent TNF-alpha and NO secretion. Desensitization was not related to tyrosine phosphorylation signal transduction but was transferred by culture supernatants in which arachidonic acid derivatives were evidenced.  (+info)

The accumulation of Man(6)GlcNAc(2)-PP-dolichol in the Saccharomyces cerevisiae Deltaalg9 mutant reveals a regulatory role for the Alg3p alpha1,3-Man middle-arm addition in downstream oligosaccharide-lipid and glycoprotein glycan processing. (8/146)

N-Glycans in nearly all eukaryotes are derived by transfer of a precursor Glc(3)Man(9)GlcNAc(2) from dolichol (Dol) to consensus Asn residues in nascent proteins in the endoplasmic reticulum. The Saccharomyces cerevisiae alg (asparagine-linked glycosylation) mutants fail to synthesize oligosaccharide-lipid properly, and the alg9 mutant, accumulates Man(6)GlcNAc(2)-PP-Dol. High-field (1)H NMR and methylation analyses of Man(6)GlcNAc(2) released with peptide-N-glycosidase F from invertase secreted by Deltaalg9 yeast showed its structure to be Manalpha1,2Manalpha1,2Manalpha1, 3(Manalpha1,3Manalpha1,6)-Manbeta1,4GlcNAcbeta1, 4GlcNAcalpha/beta, confirming the addition of the alpha1,3-linked Man to Man(5)GlcNAc(2)-PP-Dol prior to the addition of the final upper-arm alpha1,6-linked Man. This Man(6)GlcNAc(2) is the endoglycosidase H-sensitive product of the Alg3p step. The Deltaalg9 Hex(7-10)GlcNAc(2) elongation intermediates were released from invertase and similarly analyzed. When compared with alg3 sec18 and wild-type core mannans, Deltaalg9 N-glycans reveal a regulatory role for the Alg3p-dependent alpha1,3-linked Man in subsequent oligosaccharide-lipid and glycoprotein glycan maturation. The presence of this Man appears to provide structural information potentiating the downstream action of the endoplasmic reticulum glucosyltransferases Alg6p, Alg8p and Alg10p, glucosidases Gls1p and Gls2p, and the Golgi Och1p outerchain alpha1,6-Man branch-initiating mannosyltransferase.  (+info)

1ONA: A structure of the complex between concanavalin A and methyl-3,6-di-O-(alpha-D-mannopyranosyl)-alpha-D-mannopyranoside reveals two binding modes.
You may also wish to search for items by Izatt, R. and Izatt. 100 matching references were found. Oscarson, J.L.; Coxam, J.-Y.; Gillespie, S.E.; Izatt, R.M., Excess enthalpies of mixing methane with methanol, n-heptane, toluene and methylcyclohexane at 255.4 and 310.9 K and 13.8 MPa, Fluid Phase Equilib., 1996, 114, 161-74. [all data] Chen, X.; Oscarson, J.L.; Cao, H.; Gillespie, S.E.; Izatt, R.M., A new flow calorimeter designed for operation to 450.degree.C and 50 MPa, Thermochim. Acta, 1996, 285, 11-23. [all data] Wang, P.; Oscarson, J.L.; Izatt, R.M.; Watt, G.D.; Larsen, C.D., Thermodynamic parameters for the interaction of adenosine 5-diphosphate, and adenosine 5-triphosphate with Mg2+ from 323.15 to 398.15 K, J. Solution Chem., 1995, 24, 989-1012. [all data] Oscarson, J.L.; Wang, P.; Gillespie, S.E.; Izatt, R.M.; Watt, G.D.; Larsen, C.D.; Renuncio, J.A.R., Thermodynamics of protonation of AMP, ADP, and ATP from 50 to 125.degree.C, J. Solution Chem., 1995, 24, 171-86. [all data] Izatt, ...
It has always been of high interest to prepare orthogonally protected monosaccharides. To date, there are only a few examples in the literature of d-glucose
Bjerregaard-Andersen, Kaare; Johannesen, Hedda; Abdel-Rahman, Noha Mansour Hassan; Heggelund, Julie Elisabeth; Hoås, Helene Mykland; Abraha, Fana; Bousquet, Paula; Høydahl, Lene Støkken; Burschowsky, Daniel; Rojas, Gertrudis; Oscarson, Stefan; Løset, Geir Åge; Krengel, Ute (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018) ...
D-LINK DGL-4500 MANUAL PDF - D-Link DGL User Manual. Section - Configuration. The setting can be selected to allow the DGL to choose the channel with the. The following instructions
4-Methoxybenzyl Acetate chemical properties, What are the chemical properties of 4-Methoxybenzyl Acetate 104-21-2, What are the physical properties of 4-Methoxybenzyl Acetate ect.
2-((4-Methoxybenzyl)oxy)acetic acid 88920-24-5 NMR spectrum, 2-((4-Methoxybenzyl)oxy)acetic acid H-NMR spectral analysis, 2-((4-Methoxybenzyl)oxy)acetic acid C-NMR spectral analysis ect.
Alfa Aesar™ 4-Chloro-N-(4-methoxybenzyl)butyramide, 97% 100mg Alfa Aesar™ 4-Chloro-N-(4-methoxybenzyl)butyramide, 97% Chloronitrod to...
Read about the chemical and physical properties of 5,8-difluoro-1-(3-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid. Get 5,8-difluoro-1-(3-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid molecular formula, CAS number, boiling point, melting point, applications, synonyms and more here.
TY - JOUR. T1 - Direct and stereoselective synthesis of β-mannosides by anomeric o-alkylation. AU - Takahashi, Daisuke. PY - 2016. Y1 - 2016. KW - Anomeric O-alkylation. KW - Glycosylation. KW - Stereoselective. KW - β-mannosylation. UR - http://www.scopus.com/inward/record.url?scp=84997542885&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84997542885&partnerID=8YFLogxK. U2 - 10.4052/tigg.1608.6E. DO - 10.4052/tigg.1608.6E. M3 - Comment/debate. AN - SCOPUS:84997542885. VL - 28. SP - E119-E120. JO - Trends in Glycoscience and Glycotechnology. JF - Trends in Glycoscience and Glycotechnology. SN - 0915-7352. IS - 164. ER - ...
You are viewing an interactive 3D depiction of the molecule 7-ethyl-n-{(2s,3r)-3-hydroxy-4-[(3-methoxybenzyl)amino]-1-phenyl-2-butanyl}-1-methyl-3,4-dihydro-1h-[1,2,5]thiadiazepino[3,4,5-hi]indole-9-carboxamide 2,2-dioxide (C32H38N4O5S) from the PQR.
Product Name:1-(2-Methoxybenzyl)-1H-imidazole-5-carboxylic acid CAS Number: Catalouge Number:OR306010 Purity: Commodity Code:2933299090 MDL Number:MFCD25541774 Notes: Synonyms:
0061] Among the compounds of general formula (I) which fall within the context of the present invention, mention may in particular be made of the following: [0062] 1-[(S)-2-[(S)-2-benzoylamino-3-(1H-imidazol-4-yl)propionylamino]-3-(4-met- hoxyphenyl)propionyl]-3-phenylazetidin-3-yl ester of butyric acid [0063] N-[(S)-1-[(S)-2-(3-butoxy-3-o-tolylazetidin-1-yl)-1-(4-methoxybenzyl)-2-o- xoethylcarbamoyl]-2-(1H-imidazol-4-yl)ethyl]benzamide [0064] N-[(S)-1-[(S)-2-(3-butoxy-3-phenylazetidin-1-yl)-1-(4-methoxybenzyl)-2-ox- oethylcarbamoyl]-2-(1H-imidazol-4-yl)ethyl]benzamide [0065] N-[(S)-1-[(S)-2-(3-hydroxy-3-o-tolylazetidin-1-yl)-1-(4-methoxybenzyl)-2-- oxoethylcarbamoyl]-2-(1H-imidazol-4-yl)ethyl]benzamide [0066] 1-[(S)-2-[(S)-2-benzoyl amino-3-(1H-imidazol-4-yl)propionylamino]-3-(4-methoxyphenyl)propionyl]-3- -o-tolylazetidin-3-yl acetate [0067] 1-[(S)-2-[(S)-2-benzoylamino-3-(1H-imidazol-4-yl)propionylamino]-3-(4-met- hoxyphenyl)propionyl]-3-(4-fluorophenyl)azetidin-3-yl ester of butyric acid ...
DGL Synergy™ is a fast-acting, chewable formula of deglycyrrhizinated licorice (DGL), which offers support for the gastric mucosa. It contains a standardized high-quality form of DGL, the amino acid glycine, and calcium in the form of calcium glycerophosphate. DGL Synergy is a fast-acting, chewable formula of deglycy
Special note about Community Feature Content. Any content and/or opinions uploaded, expressed or submitted through any Community Feature or any other publicly available section of the Web Site (including password-protected areas), and all articles and responses to questions, other than the content explicitly authorized by the Company, are solely the opinions and responsibility of the person or entity submitting them and do not necessarily reflect the opinions of the Company. By way of example, any recommended or suggested use of products or services available from the Company that is posted through a Community Feature is not a sign of approval or recommendation by the Company. If you choose to follow any such recommendation you do so at your own risk.. Links to Third Party Sites. The Web Site may contain links to other websites on the internet. The Company is not responsible for the content, products, services or practices of any third party websites, including without limitation sites linked to ...
Please submit a detailed description of your project. We will provide you with a customized project plan to meet your research requests. You can also send emails directly to for inquiries. ...
Best price in Australia on Now Foods DGL 400 mg - 100 Lozenges from eVitamins.com. Find DGL 400 mg reviews, side effects, coupons and more from eVitamins. Fast and reliable shipping to the Australia. DGL 400 mg and other products by Now Foods for all your health needs.
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Tox21 dataset.. The Toxicology in the 21st Century (https://tripod.nih.gov/tox21/challenge/) initiative created a public database measuring toxicity of compounds, which has been used in the 2014 Tox21 Data Challenge. The dataset contains qualitative toxicity measurements for 8014 compounds on 12 different targets, including nuclear receptors and stress response pathways. Each target results in a binary label.. A common issue for multi-task prediction is that some datapoints are not labeled for all tasks. This is also the case for Tox21. In data pre-processing, we set non-existing labels to be 0 so that they can be placed in tensors and used for masking in loss computation. See examples below for more details.. All molecules are converted into DGLGraphs. After the first-time construction, the DGLGraphs will be saved for reloading so that we do not need to reconstruct them everytime.. ...
Semantic Scholar is a free, AI-powered research tool for scientific literature, based at the Allen Institute for AI.. Learn More → ...
Initialt 20-80 mg som enkeltdosis. Dosis justeringer efter mindst 4 ugers behandling. Ved forebyggelse af kardiovaskulære hændelser anbefales normalt 80 mg dgl. Børn over 9 år og unge med heterozygot familiær hyperkolesterolæmi Initialt 20 mg dgl. Dosis kan øges med intervaller på mindst 6 uger til højst 80 mg dgl. Bemærk: ...
Nyre- og hjertetransplantation Voksne. Initialt 0,75 mg 2 gange dgl. Skal anvendes i kombination med calcineurinhæmmer som mikroemulsion og et kortikosteroid. Dosis af everolimus justeres til laveste fuldblodskoncentration på 3-8 nanogram/ml, hvorefter nedtitrering af ciclosporin kan foretages. Se endvidere speciallitteratur. Levertransplantation Voksne. 1 mg 2 gange dgl. med første dosis ca. 4 uger efter transplantation. Skal anvendes i kombination med calcineurinhæmmer og et kortikosteroid. Dosis af tacrolimus nedsættes ca. 3 uger efter opstart. Se endvidere speciallitteratur. Bemærk: ...
Headline: Bitcoin & Blockchain Searches Exceed Trump! Blockchain Stocks Are Next!. The Global and Chinese Penicillin-G 4-Methoxybenzyl Ester Sulfoxide Market, 2011-2021 Market Research Report is a professional and in-depth study on the current state of the global Penicillin-G 4-Methoxybenzyl Ester Sulfoxide industry with a focus on the Chinese market. The report provides key statistics on the market status of the Penicillin-G 4-Methoxybenzyl Ester Sulfoxide manufacturers and is a valuable source of guidance and direction for companies and individuals interested in the industry.. Firstly, the report provides a basic overview of the industry including its definition, applications and manufacturing technology. Then, the report explores the international and Chinese major industry players in detail. In this part, the report presents the company profile, product specifications, capacity, production value, and 2011-2016 market shares for each company.. Through the statistical analysis, the report ...
Dr. Toone is a physical organic chemist who studies relationships between structure and activity in the context of biology. Currently active programs exist in biocatalysis/applied enzymology, ligand binding and the activity of water, and the synthesis of novel donors of nitric oxide. The study of these problems makes use of synthetic organic chemistry, traditional enzymology, isothermal titration microcalorimetry, and the techniques of directed evolution.. ...
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Seeds of Triticale (hybrid of wheat and rye) contain an N-acetylglucosamine specific lectin that was affinity purified in our laboratory (Siva Kumar, N. and Padma, K. (1996) Affinity purification of N-acetyl glucosamine specific lectin. Purification and partial characterization of Triticale lectin. Biochem. Mol. Biol. Int. 38, 1059-1066). Seed extracts also exhibited alpha-mannosidase activity that was isolated by a combination of ion exchange, hydrophobic chromatography and gel filtration. The purified enzyme is a glycoprotein with 7% carbohydrate and exhibited a native molecular mass of 1,95,000 (+/-5000) on Biogel P-200 and dissociated into two major subunits under reducing conditions of molecular masses 58 and 40 kDa, respectively. Both subunits cross-reacted with an antibody to the well-characterized jack bean alpha-mannosidase, suggesting antigenic similarity between the legume and the cereal mannosidases. Purified enzyme binds to Con A-Sepharose gel, possibly through the sugar-binding site.
We describe an approach to accelerate the search for competitive inhibitors for carbohydrate-recognition domains (CRDs). Genetically encoded fragment-based-discovery (GE-FBD) uses selection of phagedisplayed glycopeptides to dock a glycan fragment at the CRD and guide selection of Synergistic peptide motifs adjacent to the CRD. Starting from concanavalin A (ConA), a mannose (Man)-binding protein, as a bait, we narrowed a library of 10(8) glycopeptides to 86 leads that share a consensus motif, Man-WYD. Validation of synthetic leads yielded Man-WYDLF that exhibited 40 50-fold enhancement in affinity over methyl alpha-D-mannopyranoside (MeMan). Lectin array Suggested specificity: Man-WYD derivative bound only to 3 out of 17 proteins-ConA, LcH, and PSA-that bind to Man. An X-ray structure of ConA.:Man-WYD proved that the trimannoside core and Man-WYD exhibit identical CRD docking; but their extra-CRD binding modes are significantly. different. Still, they have comparable affinity and se... ...
Phosphatidylinositol mannosides (PIMs), isolated from the cell wall of mycobacteria, have been identified as an important class of glycolipids that possess immune-modulating properties. The complex mixture of structurally diverse molecules means that total syntheses of each member of this compound-family is required to determine their individual biological activities. To this end, methodology towards the synthesis of these molecules was developed. A key step in the synthesis of PIMs from the meso compound myo-inositol is the resolution of racemic mixtures of inositol derivatives. A method of selectively acetylating a single enantiomer of racemic 2,3-O-isopropylidene-myo-inositol-5,6-diols, containing a range of protecting groups at O-1 and O-4, was developed using C. antarctica Lipase B (immobilised on acrylic beads, marketed as Novozym 435). This highly efficient chemoenzymatic kinetic resolution converted one hand of the racemate into the O-5 monoacetate leaving the other hand unreacted ...
Bernardi A, Jiménez-Barbero J, Casnati A, De Castro C, Darbre T, Fieschi F, Finne J, Funken H, Jaeger KE, Lahmann M, Lindhorst TK, Marradi M, Messner P, Molinaro A, Murphy PV, Nativi C, Oscarson S, Penadés S, Peri F, Pieters RJ, Renaudet O, Reymond JL, Richichi B, Rojo J, Sansone F, Schäffer C, Turnbull WB, Velasco-Torrijos T, Vidal S, Vincent S, Wennekes T, Zuilhof H, Imberty A (2013) Multivalent glycoconjugates as anti-pathogenic agents. Chemical Society reviews, 42 (11):4709-4727 [DOI] [Details] ...
Synthesis of p-Isothiocyanatophenyl 3-O-(3,6-Dideoxy-alpha-D-xylo-hexopyranosyl)-alpha-D-mannopyranoside.. Eklind, Karin; Garegg, Per J.; Gotthammar, Birgitta ...
I originally tried DGL Licorice by Enzymatic Therapy because I was desperate to get off Omeprazole (some advice: gradually wean yourself off it, never stop cold turkey). While this DGL was working great for my GERD at night, it was making my stomach hurt during the day. I later found out it was because this brand contained sorbitol, which can be aggravating if your stomach has issues. Why the manufacturers would put this ingredient in something meant to help your stomach makes zero sense. Luckily, I read in a forum a person recommending Natural Factors brand because its soribitol-free. Not only does this brand taste nice, but its been wonderful for my GERD. Been taking it for months, no irritation to my stomach! Highly recommend. Now if only my GERD would just go away permanently... Hopefully! ...
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Methylmannosides: Mannosides formed by the reaction of the hydroxyl group on the anomeric carbon atom of mannose with methyl alcohol. They include both alpha- and beta-methylmannosides.
α-グルコシダーゼの基質特異性を解明するため,PNPα-D-gucopyranosie(1)の3-デオキシ体と6-デオキシ体(新規化合物)をMethyl α-D-glucopyranosideからそれぞれ7および4工程で合成した.1HNMRおよび分子力場計算から,これらも1と同様に重水中で4C1イス型構造を維持していることを確認した.これらを含むPNPα-D-glucopyranosideの4種のデオキシ体に対するrice由来α-glucosidaeの加水分解活性を測定した結果,3-,4-,および6-デオキシ体は加水分解されなかったが,2-デオキシ体はよく加水分解された.そこで,1および2-デオキシ基質について反応速度論的な解析を行った.. 3- and 6-Monodeoxy derivatives of ρ-nitrophenyl (PNP) α-D-glucopyranoside (1) were prepared from methyl α-D-glucopyranoside and confirmed to retain 4C1 chair conformations in D2O by 1H-NMR. Rice α-glucosidase did not hydrolyze the 3-, 4- and 6-deoxy derivatives of 1, but revealed high ...
A DGL tree safety survey provides tree owners and managers with a professional response to tree safety and liability, for individual trees or large projects.
Novel amine and amidine derivatives of di-O-(n-higher alkyl and alkenyl)-glycerols and -propanediols, and their pharmaceutically acceptable acid addition salts, are useful for combating viral infections in mammals. Of particular interest is 1,3-di-O-(n-hexadecyl)-2-O-(3-aminopropyl)-glycerol, and its pharmaceutically acceptable acid addition salts.
PIMS Special Speaker: Configurations of points and lines - A brief survey. A k-configuration is a finite collection of n points and n lines, such that each of the n points is on precisely k lines and each line contains precisely k points. Some relevant results were known long ago, but the recent years have seen a large n more››. University of Victoria. ...
eBiochemicals provides information on the O-(3-Methoxybenzyl)hydroxylamine hydrochloride(O-[(3-Methoxyphenyl)methyl]hydroxylamine hydrochloride; O-(3-methoxybenzyl)hydroxylamine hydrochloride): structure, NMR,MS,IR,spectral data, msds, molecular formula, cas, physical and chemical properties, and suppliers.
3,5-Difluoro-2-methoxybenzyl bromide (CAS 886500-63-6) Market Research Report 2018 aims at providing comprehensive data on 3,5-difluoro-2-methoxybenzyl
Fig. 2. Biofilm formation by E. coli cells expressing FimH variants. Each FimH variant is indicated by its expression plasmid. (A) Biofilm formation on a microtiter plate surface by cells expressing the K-12 fimH allele when grown in LB under static conditions. (B) Biofilm formation on a microtiter plate surface by cells expressing FimH variants when grown in LB under HDF conditions. Note that no biofilm is produced by the K-12fimH allele (pMAS1) under these conditions. (C) Quantification of biofilm formation as determined by the amount of crystal violet staining for each of the FimH variants. All experiments were performed in the presence and absence of methyl-α-d-mannopyranoside (α mm). Results are expressed as the average of four independent experiments (± standard deviation). ...
palmerolide A; (E)-ethyl octa-2,7-dienoate; (R,E)-ethyl 7,8-dihydroxyoct-2-enoate; (R,E)-ethyl 8-((tert-butyldiphenylsilyl)oxy)-7-hydroxyoct-2-enoate; (R,E)-ethyl 8-((tert-butyldiphenylsilyl)oxy)-7-(methoxymethoxy) oct-2-enoate; (R,E)-ethyl 8-hydroxy-7-(methoxymethoxy)oct-2-enoate; (R,E)-ethyl 7-(methoxymethoxy)-8-((methylsulfonyl)oxy)oct-2-enoate; (R,E)-ethyl 8-iodo-7-(methoxymethoxy)oct-2-enoate; (4S,5S)-dimethyl 2,2-dimethyl-1,3-dioxolane -4,5-dicarboxylate; ((4R,5R)-2,2-dimethyl-1,3-dioxolane-4,5-diyl)dimethanol; ((4R,5R)-5-(((4-methoxybenzyl)oxy)methyl)-2,2-dimethyl-1,3-dioxolan-4-yl)methanol; ((4R,5R)-5-(((4-methoxybenzyl)oxy)methyl)-2,2-dimethyl-1,3-dioxolan-4-yl)methyl4-methylbenzene sulfonate; (2R,3R)-2,3-dihydroxy-4-((4-methoxybenzyl)oxy)butyl-4-methylbenzenesulfonate; (R)-2-((4-methoxybenzyl)oxy)-1-((R)-oxiran-2-yl)ethanol; (R)-2-((R)-2-((4-methoxybenzyl)oxy)-1-(methoxy methoxy)ethyl) oxirane; (2R,3R)-1-((4-methoxy benzyl)oxy)-2-(methoxymethoxy)hex-5-yn-3-ol; ...
The thermodynamics of a monoclonal antibody (mAb)-peptide interaction have been characterized by isothermal titration microcalorimetry. GCC:B10 mAb, generated against human guanylyl cyclase C, a membrane-associated receptor and a potential marker for metastatic colon cancer, recognizes the cognate peptide epitope HIPPENIFPLE and its two contiguous mimotopes, HIPPEN and ENIFPLE, specifically and reversibly. The exothermic binding reactions between 6.4 and 42 degreeC are driven by dominant favorable enthalpic contributions between 20 and 42 degreeC, with a large negative heat capacity (DELTACp) of -421 +- 27 cal mol-1 K-1. The unfavorable negative value of entropy (DELTASb0) at 25 degreeC, an unusual feature among protein-protein interactions, becomes a positive one below an inversion temperature of 20.5 degreeC. Enthalpy-entropy compensation due to solvent reorganization accounts for an essentially unchanged free energy of interaction (DELTADELTAGb0 simeq 0). The role of water molecules in the ...
Nα-9-Fluorenylmethoxycarbonyl-S-(4-methoxybenzyl)-L-cysteine (CAS 141892-41-3) Market Research Report 2018 aims at providing comprehensive data on
In the 1940s licorice was discovered to be useful in treating peptic ulcers. Unfortunately, it had side effects that lead to high blood pressure, potassium loss, and fluid retention.. Researchers discovered that the ingredient in licorice that caused those side effects was glycyrrhizin. They were able to remove 97% of this chemical and the result was a product called deglycyrrhizinated licorice, DGL. DGL maintained its healing properties but had no side effects.. DGL was first used to heal ulcers in the stomach and duodenum without suppressing stomach acids. DGL worked just as good as the drugs Zantac or Tagamet that are designed to suppress stomach acid.. As more people used DGL, they found they got relief from a variety of stomach issues - heartburn, acid reflux, indigestion, bloating, and gas. In addition, they found using DGL was better than using antacids or acid blockers.. DGL works by improving and restoring the integrity of the esophageal, stomach and duodenum lining. It does this ...
Many cellular reactions involve both hydrophobic and hydrophilic molecules that reside within the chemically distinct environments defined by the phospholipid-based membranes and the aqueous lumens of cytoplasm and organelles.. Enzymes performing this type of reaction are required to access a lipophilic substrate located in the membranes and to catalyze its reaction with a polar, water-soluble compound. Here we focus on two enzymes involved in the early steps of the phosphatidylinositol mannosides (PIMs) biosynthetic pathway, unique glycolipids found in abundant quantities in the inner and outer membranes of the cell envelope of all Mycobacterium species. They are based on a phosphatidylinositol lipid anchor carrying one to six mannose residues and up to four acyl chains. PIMs are considered not only essential structural components of the cell envelope but also the structural basis of the lipoglycans lipomannan and lipoarabinomannan, important molecules implicated in host-pathogen interactions ...
Buts, L., A. Wellens, I. Van Molle, L. Wyns, R. Loris, M. Lahmann, S. Oscarson, H. De Greve, and J. Bouckaert, Impact of natural variation in bacterial F17G adhesins on crystallization behaviour., Acta Crystallogr D Biol Crystallogr, vol. 61, issue Pt 8, pp. 1149-59, 2005 Aug. ...
Selby Defends IBF Crown Against Jon Barros With One Eye on a Unification Fight By: Phil Oscarson Former WBA World featherweight champion Jonathon Victor
Multifunctional supported bimetallic catalysts for a cascade reaction with hydrogen auto transfer: synthesis of 4-phenylbutan-2-ones from 4-methoxybenzyl alcohols - Morad MH, Nowicka E, Douthwaite JM, Iqbal S, Miedziak PJ, Brett GL, He Q, Morgan DJ, Edwards JK, Alshammari H, Bethell D, Knight DW, Sankar M, Hutchings GJ (2017). Cardiff University. 10.17035/d.2017.0033515199. ...
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Characterizing the interactions and stability of biomolecules. Microcalorimetry is used to study reactions involving biomolecules, including interactions
Characterizing the interactions and stability of biomolecules. Microcalorimetry is used to study reactions involving biomolecules, including interactions
Oralt Voksne. 1 strøget doseringsmål (ca. 15 g) 3-4 gange dgl. Ved P-kalium > 6 mmol/l gentages dosis med 1-2 timers mellemrum, indtil P-kalium er < 5 mmol/l. Rektalt 30 g opblandet i 150 ml laktulose eller methylcellulose. Opløsningen skal forblive i tarmen i minimum 30-45 min. - hvis muligt op til 9 timer. ...
Overall, this is a powerful method for solid-phase synthesis of β-mannosides, which has great potential to be further extended ... The polymer-supported synthesis of β-mannosides based on the Crich's protocol has also been studied in the same laboratories. ...
"Analysis of a new mannosyltransferase required for the synthesis of phosphatidylinositol mannosides and lipoarbinomannan ...
The enzyme catalyzes the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides, and can cleave ...
CPU and memory on the same chip Passive intermodulation of signals Phosphatidylmyo-inositol mannosides, a glycolipid component ...
While 1,2-trans-glycosides (e.g. α-mannosides and β-glucosides) can be synthesised easily in the presence of a participating ...
... non-reducing beta-D-mannose residues in beta-D-mannosides This gene encodes a member of the glycosyl hydrolase 2 family. The ...
... (PIMs) are a family of glycolipids found in the cell wall of Mycobacterium tuberculosis. ...
Phosphatidylmyo-inositol Mannosides (PIMs) are a family of glycolipids found in the cell wall of Mycobacterium tuberculosis. ...
... Dong, Hai KTH, School of ... On the basis of this effect, efficient synthetic routes to beta-D-mannosides and beta-D-talosides, from the corresponding beta- ... Based on this effect, efficient synthetic routes to a range of carbohydrate structures, notably β-D-mannosides and β-D- ... Based on this effect, efficient synthetic routes to a range of carbohydrate structures, notably β-D-mannosides and β-D- ...
... gave 4 different 2-C-alkynyl branched mannosides. Lindlar hydrogenation of the latter under optimized conditions in ... dimethylformamide afforded a series of 2-C-cis-alkenyl mannosides. X-ray molecular structures of benzyl 3,4,6-tri-O-benzyl-β-d- ... Borowski D, Menzel M, Ziegler T. 2-C-Alkynyl and 2-C-cis-Alkenyl β-Mannosides with Acetal Protected γ-Aldehyde Functionality ... Borowski, D.; Menzel, M.; Ziegler, T. 2-C-Alkynyl and 2-C-cis-Alkenyl β-Mannosides with Acetal Protected γ-Aldehyde ...
Binding of β-D-glucosides and β-D-mannosides by rice and barley β-D-glycosidases with distinct substrate specificities. ... Binding of β-d-Glucosides and β-d-Mannosides by Rice and Barley β-d-Glycosidases with Distinct Substrate ...
Home / Event / BIFI Talk: Structural basis of phosphatidyl mannosides biosynthesis in mycobacteria: membrane enzymes working at ... BIFI Talk: Structural basis of phosphatidyl mannosides biosynthesis in mycobacteria: membrane enzymes working at the interface ... BIFI Talk: Structural basis of phosphatidyl mannosides biosynthesis in mycobacteria: membrane enzymes working at the interface ... Título: Structural basis of phosphatidyl mannosides biosynthesis in mycobacteria: membrane enzymes working at the interface ...
Highly Purified Mycobacterial Phosphatidylinositol Mannosides Drive Cell-Mediated Responses and Activate NKT Cells in Cattle ( ... Highly Purified Mycobacterial Phosphatidylinositol Mannosides Drive Cell-Mediated Responses and Activate NKT Cells in Cattle ( ...
GLYKOLIPIDE (BIOCHEMIE); GLYKOPROTEINE + GLYKOPEPTIDE (BIOCHEMIE); GLYKOSYLPHOSPHATIDYLINOSITIDE (BIOCHEMIE); ASYMMETRISCHE CHEMISCHE SYNTHESE + ENANTIOSELEKTIVE SYNTHESE (ORGANISCHE SYNTHESE); GLYCOLIPIDS (BIOCHEMISTRY); GLYCOPROTEINS + GLYCOPEPTIDES (BIOCHEMISTRY); GLYCOSYL PHOSPHATIDYLINOSITOL (BIOCHEMISTRY); ASYMMETRIC CHEMICAL SYNTHESIS + ENANTIOSELECTIVE SYNTHESIS (ORGANIC SYNTHESIS ...
The strains show significant differences in their ability to utilize inositol, sucrose, lactose, α-mannosides, α-1,4-glucosides ... The strains show significant differences in their ability to utilize inositol, sucrose, lactose, α-mannosides, α-1,4-glucosides ... α-Mannosides and Inositol-phosphate Utilization. Only one of the six strains, 1MC16, possesses the ability to utilize either ... Significant differences exist in the ability of the sequenced strains to utilize inositol, sucrose, lactose, α-mannosides, α-1, ...
Takahashi, D. (2016). Direct and stereoselective synthesis of β-mannosides by anomeric o-alkylation. Trends in Glycoscience and ... Takahashi, D 2016, Direct and stereoselective synthesis of β-mannosides by anomeric o-alkylation, Trends in Glycoscience and ... Direct and stereoselective synthesis of β-mannosides by anomeric o-alkylation. In: Trends in Glycoscience and Glycotechnology. ... Direct and stereoselective synthesis of β-mannosides by anomeric o-alkylation. Trends in Glycoscience and Glycotechnology. 2016 ...
Keywords: 2,3-O-isopropylidenation; α-D-mannosides; trisaccharide 2,3-O-isopropylidenation; α-D-mannosides; trisaccharide ...
... phosphatidylinositol-containing mannosides (PIMs), etc., that represent as major glycans present in the outermost layer of M. ...
5,416,016 to Low et al.); mannosides (Umezawa et al., (1988) Biochem. Biophys. Res. Commun. 153: 1038); antibodies (P. G. ...
Terminal alpha-d-mannosides are critical during sea urchin gastrulation.. [So] Source:. Zygote;24(5):775-82, 2016 Oct.. ...
Diazirine-functionalized mannosides for photoaffinity labeling: trouble with FimH.. Beiroth F, Koudelka T, Overath T, Knight SD ...
Terminal alpha-d-mannosides are critical during sea urchin gastrulation. Zygote. 2016 Oct;24(5):775-82. doi: 10.1017/ ...
Liposomes based on phosphatidylinositol mannosides, and pharmaceutical compositions containing them. EP0391369B1 *. Apr 4, 1990 ...
F1C fimbriae do not bind to D-mannosides or confer agglutination of any known types of erythrocytes or yeast. It was previously ...
Biosynthesis of mycobacterial phosphatidylinositol mannosides. Biochem. J. 378 : 589-597.. OpenUrlCrossRefPubMedWeb of Science ... Identification of the required acyltransferase step in the biosynthesis of the phosphatidylinositol mannosides of Mycobacterium ... Lipoarabinomannans (LAMs) and phosphatidylinositol mannosides (PIMs) are abundant glycolipids in the cell walls of all ... The most important of these are the phosphatidylinositol mannosides (PIMs) and their hyperglycosylated derivatives, lipomannan ...
... mannosides, antibiotic resistance ... Mannosides Fight Urinary Infections Sugar-based antibiotics ...
Thus, ManR regulates the complete pathway for degradation of extracellular α-mannosides to the central metabolism (Additional ... mannosides), and BT4663 (heparin) [9, 15, 30]. In agreement with these data, genes encoding three of these HTCSs are located ... of the α-mannoside utilization metabolic and regulatory pathways can be explained by the variability of the α-mannosides ...
Differential binding to mannosides and uroepithelial cells. J. Biol. Chem. 272, 17880-17886. ...
Acylation state of the phosphatidylinositol mannosides from Mycobacterium bovis bacillus Calmette Guerin and ability to induce ... myo-inositol mannosides (PIM; 20) are capable of eliciting CD1-mediated T cell responses. With the exception of ... myo-inositol mannosides; PPD, purified protein derivative of M. tuberculosis; SGL, sulfoglycolipids. ...
Reversible binding to cell-surface mannosides may also be important. This suggests an approach to the treatment of infections-- ...
Various mannosides have been tested for binding to E. coli over the years, and the observations are similar-binding in vitro, ... Mannans Versus Mannose and Synthetic Mannosides. The natural remedy proposed here to treat E. coli UTI is the SUPERMANNAN brand ... E. coli infecting the bladder likely metabolizes these complex mannosides, which are yeast mannan oligosaccharides or MOS. The ... synthetic mannosides) [5]. However, this in vitro binding inhibition has not led to a successful UTI therapy for humans. The ...
Heptyl -D-Mannosides Grafted on a -Cyclodextrin Core To Interfere with Escherichia coli Adhesion: An In Vivo Multivalent Effect ... The Antiadhesive Strategy in Crohns Disease: Orally Active Mannosides to Decolonize Pathogenic Escherichia coli from the Gut. ... Polymeric mannosides prevent DC-SIGN-mediated cell-infection by cytomegalovirus. Brument, S.; Cheneau, C.; Brissonnet, Y.; ...
... tuberculosis Rv2252 encodes a diacylglycerol kinase involved in the biosynthesis of phosphatidylinositol mannosides (PIMs). Mol ...
Here, we describe the synthesis of 2-C-branched mannosides and evaluation of their pharmacodynamic properties. ITC experiments ... 2-C-Branched mannosides as a novel family of FimH antagonists - Synthesis and biological evaluation. ...
The recombinant protein binds mannosides and is oligomeric, up to the hexameric form. Two truncated proteins showed that the ...
Diazirine-functionalized mannosides for photoaffinity labeling: trouble with FimH2018In: Beilstein Journal of Organic Chemistry ... Following our earlier work, we have here designed and synthesized diazirine-functionalized mannosides as high-affinity FimH ...
  • Here we focus on two enzymes involved in the early steps of the phosphatidylinositol mannosides (PIMs) biosynthetic pathway, unique glycolipids found in abundant quantities in the inner and outer membranes of the cell envelope of all Mycobacterium species. (bifi.es)
  • M. tuberculosis and other pathogenic mycobacterial species produce a variety of glycogen or glycogen-associated molecules like lipoarabinomannan (LAM), trehalose monomycolate (TMM), phenolic glycolipids (PGLs), trehalose dimycolate (TDM), phosphatidylinositol-containing mannosides (PIMs), etc., that represent as major glycans present in the outermost layer of M. tuberculosis . (springer.com)
  • Lipoarabinomannans (LAMs) and phosphatidylinositol mannosides (PIMs) are abundant glycolipids in the cell walls of all corynebacteria and mycobacteria, including the devastating human pathogen Mycobacterium tuberculosis . (asm.org)
  • 1 Included among these is the family of mannosylated phosphatidylinositols, commonly known as phosphatidylinositol mannosides or PIMs, 2 that are of great interest due to their biological activity and synthetic accessibility. (pubmedcentralcanada.ca)
  • Biosynthesis of mycobacterial phosphatidylinositol mannosides. (umassmed.edu)
  • Defining the interaction of human soluble lectin ZG16p and mycobacterial phosphatidylinositol mannosides. (mpg.de)
  • This work provides the first direct evidence of the essentiality of phosphatidylinositol mannosides for the growth of mycobacteria. (labome.org)
  • Intercalated within this lipid environment are the lipids that have intrigued researchers for over five decades: the phthiocerol dimycocerosate, cord factor/dimycolyltrehalose, the sulfolipids, the phosphatidylinositol mannosides, etc. (biomedsearch.com)
  • Phosphatidylmyo-inositol Mannosides (PIMs) are a family of glycolipids found in the cell wall of Mycobacterium tuberculosis. (wikipedia.org)
  • The enzyme, found in Corynebacteriales, is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIMs). (genome.jp)
  • Scientists call these drugs mannosides because they are derivatives of mannose and block the bacterial glue's ability to bind to mannose found on the surface of cells in the bladder. (healthcanal.com)
  • The partnership creates a joint project between Fimbrion and DPAc to develop a class of mannose-containing small molecule compounds called mannosides. (fiercebiotech.com)
  • Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides. (uniprot.org)
  • This gene encodes an enzyme that hydrolyzes terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. (genecards.org)
  • Hultgren and co-senior author James W. Janetka, PhD , an associate professor of biochemistry and molecular biophysics, previously created mannosides, modified forms of a sugar called mannose, that the bacteria favor over typical sugars on the bladder wall. (wustl.edu)
  • Previously, Hultgren and co-author, James W. Janetka , an associate professor of biochemistry and molecular biophysics at Washington University, chemically modified mannose to create a group of molecules, called mannosides, that are similar to mannose but changed in a way that the bacteria latch onto them more tightly with their pili. (healthcanal.com)
  • Unlike mannose receptors, though, these mannosides are not attached to the bladder wall, so bacteria that take hold of mannosides instead of mannose receptors are flushed out with urine. (healthcanal.com)
  • Mannosides formed by the reaction of the hydroxyl group on the anomeric carbon atom of mannose with methyl alcohol. (curehunter.com)
  • Nous avons tout d'abord mis en évidence par diffusion dynamique et statique de la lumière, la formation d'agrégats entre ces glycopolymères et FimH, la lectine à l'origine de la fixation de souches de bactéries E coli, traduisant des interactions fortes entre les motifs mannosides et les sites de reconnaissance au mannose de la lectine. (archives-ouvertes.fr)
  • On the basis of this effect, efficient synthetic routes to beta-D-mannosides and beta-D-talosides, from the corresponding beta-D-galactosides and beta-D-glucosides, have been designed. (diva-portal.org)
  • Terminal alpha-d-mannosides are critical during sea urchin gastrulation. (csun.edu)
  • Empadinhas, N. "Unveiling mycobacterial methylmannose polysaccharide biosynthesis: a unique 1-O-methyltransferase specific for 3-O-methylated mannosides. (unl.pt)
  • C-Type Lectin Receptor DCAR Recognizes Mycobacterial Phosphatidyl-Inositol Mannosides to Promote a Th1 Response during Infection. (genscript.com)
  • When mice with UTIs were given the mannosides, the E. coli in their bladders grabbed hold of those molecules and were swept away. (wustl.edu)
  • The authors suggest that this selective depletion of intestinal UPEC by mannosides could be used to reduce the occurrence of UTIs. (natureasia.com)
  • Hultgren and Janetka are continuing to develop more potent mannosides. (healthcanal.com)
  • According to Hultgren, the approach he and Janetka are using to develop the mannosides could be harnessed to treat infections in other parts of the body, such as ear or kidney infections. (healthcanal.com)
  • Washington University holds a patent on the mannosides developed by Hultgren and Janetka. (healthcanal.com)
  • That FimH is what Hultgren hopes to target using a class of compounds that prevent FimH from binding in the first place, called mannosides. (thedailybeast.com)
  • Aromatic alpha-mannosides are potent inhibitors of type 1 fimbriated E. coli, being up to 1000 times more active than MealphaMan, with affinities in the nanomolar range. (nih.gov)
  • Nous avons synthétisé, par polymérisation radicalaire contrôlée, une série de glycopolymères linéaires ou en étoile présentant des masses molaires, des densités en mannoside et des microstructures modulables dans le but d'évaluer l'influence de ces paramètres sur les processus d'interactions avec diverses souches de bactéries E coli (AIEC LF82 et UTI 89). (archives-ouvertes.fr)
  • Phytotherapeutics and small-molecular compounds like mannosides have the potential to become an integral part in a multi-modal treatment concept for the treatment and prevention of urinary tract infections. (urotoday.com)
  • Synthesis of galactose-mimicking 1H-(1,2,3-triazol-1-yl)-mannosides as selective galectin-3 and 9N inhibitors. (lu.se)
  • Diazirine-functionalized mannosides for photoaffinity labeling: trouble with FimH. (nih.gov)
  • X-ray molecular structures of benzyl 3,4,6-tri- O -benzyl-β- d - arabino -hexos-2-ulo-1,5-pyranoside and of the branched glycoside benzyl 3,4,6-tri- O -benzyl-2- C -(( Z )-3,3-dibenzyloxyprop-1-en-1-yl)-β- d -mannopyranoside are reported. (mdpi.com)
  • Based on this effect, efficient synthetic routes to a range of carbohydrate structures, notably β-D-mannosides and β-D-talosides, were designed by use of double parallel and double serial inversion. (diva-portal.org)
  • Analysis of the solubilised hemicellulose fractions revealed that they consist almost exclusively of alkyl xylosides and mannosides which could serve as valuable synthetic building blocks. (rsc.org)
  • Mannosides bypass those resistance mechanisms because they don't have to get into the cell. (healthcanal.com)
  • In addition , anthraquinone-HRL ( 17 ) selectively photo-degraded only Man(α1,6)Man, which has a high affinity for HRL, among several mannosides by recognition of both the type and glycosidic linkage profile of the sugar in an oligosaccharide. (wiley.com)
  • Overall, this is a powerful method for solid-phase synthesis of β-mannosides, which has great potential to be further extended, was established. (wikipedia.org)
  • For corn-soybean meal based feed that are most widely used in Americas and Asian countries, types of NSPs that interfere energy digestibility are galactosides, mannosides, soybean oligosaccharides (raffinose, stachyose, and verbascose). (acronymfinder.com)
  • Takahashi, D 2016, ' Direct and stereoselective synthesis of β-mannosides by anomeric o-alkylation ', Trends in Glycoscience and Glycotechnology , vol. 28, no. 164, pp. (elsevier.com)