Mannose. Medical search

A hexose or fermentable monosaccharide and isomer of glucose from manna, the ash Fraxinus ornus and related plants. (From Grant & Hackh's Chemical Dictionary, 5th ed & Random House Unabridged Dictionary, 2d ed)

A subclass of lectins that are specific for CARBOHYDRATES that contain MANNOSE.

A receptor that is specific for IGF-II and mannose-6-phosphate. The receptor is a 250-kDa single chain polypeptide which is unrelated in structure to the type 1 IGF receptor (RECEPTOR, IGF TYPE 1) and does not have a tyrosine kinase domain.

Phosphoric acid esters of mannose.

A nucleoside diphosphate sugar which can be converted to the deoxy sugar GDPfucose, which provides fucose for lipopolysaccharides of bacterial cell walls. Also acts as mannose donor for glycolipid synthesis.

A lipophilic glycosyl carrier of the monosaccharide mannose in the biosynthesis of oligosaccharide phospholipids and glycoproteins.

Carbohydrates consisting of between two (DISACCHARIDES) and ten MONOSACCHARIDES connected by either an alpha- or beta-glycosidic link. They are found throughout nature in both the free and bound form.

Enzymes that catalyze the transfer of mannose from a nucleoside diphosphate mannose to an acceptor molecule which is frequently another carbohydrate. The group includes EC 2.4.1.32, EC 2.4.1.48, EC 2.4.1.54, and EC 2.4.1.57.

An enzyme that catalyzes the reversible isomerization of D-mannose-6-phosphate to form D-fructose-6-phosphate, an important step in glycolysis. EC 5.3.1.8.

A class of animal lectins that bind to carbohydrate in a calcium-dependent manner. They share a common carbohydrate-binding domain that is structurally distinct from other classes of lectins.

Polysaccharides consisting of mannose units.

The largest class of organic compounds, including STARCH; GLYCOGEN; CELLULOSE; POLYSACCHARIDES; and simple MONOSACCHARIDES. Carbohydrates are composed of carbon, hydrogen, and oxygen in a ratio of Cn(H2O)n.

Glycoside hydrolases that catalyze the hydrolysis of alpha or beta linked MANNOSE.

Compounds functioning as activated glycosyl carriers in the biosynthesis of glycoproteins and glycophospholipids. They include the polyisoprenyl pyrophosphates.

Cell surface proteins that bind signalling molecules external to the cell with high affinity and convert this extracellular event into one or more intracellular signals that alter the behavior of the target cell (From Alberts, Molecular Biology of the Cell, 2nd ed, pp693-5). Cell surface receptors, unlike enzymes, do not chemically alter their ligands.

Glycosides formed by the reaction of the hydroxyl group on the anomeric carbon atom of mannose with an alcohol to form an acetal. They include both alpha- and beta-mannosides.

The sequence of carbohydrates within POLYSACCHARIDES; GLYCOPROTEINS; and GLYCOLIPIDS.

Simple sugars, carbohydrates which cannot be decomposed by hydrolysis. They are colorless crystalline substances with a sweet taste and have the same general formula CnH2nOn. (From Dorland, 28th ed)

Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.

The chemical or biochemical addition of carbohydrate or glycosyl groups to other chemicals, especially peptides or proteins. Glycosyl transferases are used in this biochemical reaction.

An enzyme that catalyzes the HYDROLYSIS of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. The enzyme plays a role in the processing of newly formed N-glycans and in degradation of mature GLYCOPROTEINS. There are multiple isoforms of alpha-mannosidase, each having its own specific cellular location and pH optimum. Defects in the lysosomal form of the enzyme results in a buildup of mannoside intermediate metabolites and the disease ALPHA-MANNOSIDOSIS.

These compounds function as activated monosaccharide carriers in the biosynthesis of glycoproteins and oligosaccharide phospholipids. Obtained from a nucleoside diphosphate sugar and a polyisoprenyl phosphate.

An aldohexose that occurs naturally in the D-form in lactose, cerebrosides, gangliosides, and mucoproteins. Deficiency of galactosyl-1-phosphate uridyltransferase (GALACTOSE-1-PHOSPHATE URIDYL-TRANSFERASE DEFICIENCY DISEASE) causes an error in galactose metabolism called GALACTOSEMIA, resulting in elevations of galactose in the blood.

The characteristic 3-dimensional shape of a carbohydrate.

Proteins which contain carbohydrate groups attached covalently to the polypeptide chain. The protein moiety is the predominant group with the carbohydrate making up only a small percentage of the total weight.

Proteins that share the common characteristic of binding to carbohydrates. Some ANTIBODIES and carbohydrate-metabolizing proteins (ENZYMES) also bind to carbohydrates, however they are not considered lectins. PLANT LECTINS are carbohydrate-binding proteins that have been primarily identified by their hemagglutinating activity (HEMAGGLUTININS). However, a variety of lectins occur in animal species where they serve diverse array of functions through specific carbohydrate recognition.

A class of morphologically heterogeneous cytoplasmic particles in animal and plant tissues characterized by their content of hydrolytic enzymes and the structure-linked latency of these enzymes. The intracellular functions of lysosomes depend on their lytic potential. The single unit membrane of the lysosome acts as a barrier between the enzymes enclosed in the lysosome and the external substrate. The activity of the enzymes contained in lysosomes is limited or nil unless the vesicle in which they are enclosed is ruptured. Such rupture is supposed to be under metabolic (hormonal) control. (From Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)

Phosphoric acid esters of dolichol.

Mannosides formed by the reaction of the hydroxyl group on the anomeric carbon atom of mannose with methyl alcohol. They include both alpha- and beta-methylmannosides.

The N-acetyl derivative of glucosamine.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

A group of enzymes that catalyze an intramolecular transfer of a phosphate group. It has been shown in some cases that the enzyme has a functional phosphate group, which can act as the donor. These were previously listed under PHOSPHOTRANSFERASES (EC 2.7.-). (From Enzyme Nomenclature, 1992) EC 5.4.2.

An intracellular proteinase found in a variety of tissue. It has specificity similar to but narrower than that of pepsin A. The enzyme is involved in catabolism of cartilage and connective tissue. EC 3.4.23.5. (Formerly EC 3.4.4.23).

Cellular processes in biosynthesis (anabolism) and degradation (catabolism) of CARBOHYDRATES.

A specific mannose-binding member of the collectin family of lectins. It binds to carbohydrate groups on invading pathogens and plays a key role in the MANNOSE-BINDING LECTIN COMPLEMENT PATHWAY.

These compounds function as activated glycosyl carriers in the biosynthesis of glycoproteins and glycophospholipids. Include the pyrophosphates.

Enzymes that catalyze the hydrolysis of N-acylhexosamine residues in N-acylhexosamides. Hexosaminidases also act on GLUCOSIDES; GALACTOSIDES; and several OLIGOSACCHARIDES.

An enzyme that catalyzes the hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides. The enzyme plays a role in the lysosomal degradation of the N-glycosylprotein glycans. Defects in the lysosomal form of the enzyme in humans result in a buildup of mannoside intermediate metabolites and the disease BETA-MANNOSIDOSIS.

An indolizidine alkaloid from the plant Swainsona canescens that is a potent alpha-mannosidase inhibitor. Swainsonine also exhibits antimetastatic, antiproliferative, and immunomodulatory activity.

A group of related enzymes responsible for the endohydrolysis of the di-N-acetylchitobiosyl unit in high-mannose-content glycopeptides and GLYCOPROTEINS.

Cellular uptake of extracellular materials within membrane-limited vacuoles or microvesicles. ENDOSOMES play a central role in endocytosis.

Protein or glycoprotein substances of plant origin that bind to sugar moieties in cell walls or membranes. Some carbohydrate-metabolizing proteins (ENZYMES) from PLANTS also bind to carbohydrates, however they are not considered lectins. Many plant lectins change the physiology of the membrane of BLOOD CELLS to cause agglutination, mitosis, or other biochemical changes. They may play a role in plant defense mechanisms.

Any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic moiety such as an acylglycerol (see GLYCERIDES), a sphingoid, a ceramide (CERAMIDES) (N-acylsphingoid) or a prenyl phosphate. (From IUPAC's webpage)

Eicosamethyl octacontanonadecasen-1-o1. Polyprenol found in animal tissues that contains about 20 isoprene residues, the one carrying the alcohol group being saturated.

The rate dynamics in chemical or physical systems.

The bacterial sugar phosphotransferase system (PTS) that catalyzes the transfer of the phosphoryl group from phosphoenolpyruvate to its sugar substrates (the PTS sugars) concomitant with the translocation of these sugars across the bacterial membrane. The phosphorylation of a given sugar requires four proteins, two general proteins, Enzyme I and HPr and a pair of sugar-specific proteins designated as the Enzyme II complex. The PTS has also been implicated in the induction of synthesis of some catabolic enzyme systems required for the utilization of sugars that are not substrates of the PTS as well as the regulation of the activity of ADENYLYL CYCLASES. EC 2.7.1.-.

A stack of flattened vesicles that functions in posttranslational processing and sorting of proteins, receiving them from the rough ENDOPLASMIC RETICULUM and directing them to secretory vesicles, LYSOSOMES, or the CELL MEMBRANE. The movement of proteins takes place by transfer vesicles that bud off from the rough endoplasmic reticulum or Golgi apparatus and fuse with the Golgi, lysosomes or cell membrane. (From Glick, Glossary of Biochemistry and Molecular Biology, 1990)

A class of C-type lectins that target the carbohydrate structures found on invading pathogens. Binding of collectins to microorganisms results in their agglutination and enhanced clearance. Collectins form trimers that may assemble into larger oligomers. Each collectin polypeptide chain consists of four regions: a relatively short N-terminal region, a collagen-like region, an alpha-helical coiled-coil region, and carbohydrate-binding region.

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

An N-acetylglycosamine containing antiviral antibiotic obtained from Streptomyces lysosuperificus. It is also active against some bacteria and fungi, because it inhibits the glucosylation of proteins. Tunicamycin is used as tool in the study of microbial biosynthetic mechanisms.

A genetically heterogeneous group of heritable disorders resulting from defects in protein N-glycosylation.

The sum of the weight of all the atoms in a molecule.

Five-carbon furanose sugars in which the OXYGEN is replaced by a NITROGEN atom.

An alpha-glucosidase inhibitor with antiviral action. Derivatives of deoxynojirimycin may have anti-HIV activity.

A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.

An analytical technique for resolution of a chemical mixture into its component compounds. Compounds are separated on an adsorbent paper (stationary phase) by their varied degree of solubility/mobility in the eluting solvent (mobile phase).

A group of inherited metabolic diseases characterized by the accumulation of excessive amounts of acid mucopolysaccharides, sphingolipids, and/or glycolipids in visceral and mesenchymal cells. Abnormal amounts of sphingolipids or glycolipids are present in neural tissue. INTELLECTUAL DISABILITY and skeletal changes, most notably dysostosis multiplex, occur frequently. (From Joynt, Clinical Neurology, 1992, Ch56, pp36-7)

A chromatographic technique that utilizes the ability of biological molecules to bind to certain ligands specifically and reversibly. It is used in protein biochemistry. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

Established cell cultures that have the potential to propagate indefinitely.

A well-characterized neutral peptide believed to be secreted by the LIVER and to circulate in the BLOOD. It has growth-regulating, insulin-like and mitogenic activities. The growth factor has a major, but not absolute, dependence on SOMATOTROPIN. It is believed to be a major fetal growth factor in contrast to INSULIN-LIKE GROWTH FACTOR I, which is a major growth factor in adults.

The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)

Chromatography on non-ionic gels without regard to the mechanism of solute discrimination.

A non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue. It is biosynthesized from ASPARTIC ACID and AMMONIA by asparagine synthetase. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)

Compounds containing carbohydrate or glycosyl groups linked to phosphatidylinositols. They anchor GPI-LINKED PROTEINS or polysaccharides to cell membranes.

A beta-N-Acetylhexosaminidase that catalyzes the hydrolysis of terminal, non-reducing 2-acetamido-2-deoxy-beta-glucose residues in chitobiose and higher analogs as well as in glycoproteins. Has been used widely in structural studies on bacterial cell walls and in the study of diseases such as MUCOLIPIDOSIS and various inflammatory disorders of muscle and connective tissue.

Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.

The movement of materials (including biochemical substances and drugs) through a biological system at the cellular level. The transport can be across cell membranes and epithelial layers. It also can occur within intracellular compartments and extracellular compartments.

A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.

An amidohydrolase that removes intact asparagine-linked oligosaccharide chains from glycoproteins. It requires the presence of more than two amino-acid residues in the substrate for activity. This enzyme was previously listed as EC 3.2.2.18.

A hexosaminidase specific for non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. It acts on GLUCOSIDES; GALACTOSIDES; and several OLIGOSACCHARIDES. Two specific mammalian isoenzymes of beta-N-acetylhexoaminidase are referred to as HEXOSAMINIDASE A and HEXOSAMINIDASE B. Deficiency of the type A isoenzyme causes TAY-SACHS DISEASE, while deficiency of both A and B isozymes causes SANDHOFF DISEASE. The enzyme has also been used as a tumor marker to distinguish between malignant and benign disease.

The N-acetyl derivative of galactosamine.

Enzymes that catalyze the exohydrolysis of 1,4-alpha-glucosidic linkages with release of alpha-glucose. Deficiency of alpha-1,4-glucosidase may cause GLYCOGEN STORAGE DISEASE TYPE II.

Cytoplasmic vesicles formed when COATED VESICLES shed their CLATHRIN coat. Endosomes internalize macromolecules bound by receptors on the cell surface.

Chromatography on thin layers of adsorbents rather than in columns. The adsorbent can be alumina, silica gel, silicates, charcoals, or cellulose. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

Any of various enzymatically catalyzed post-translational modifications of PEPTIDES or PROTEINS in the cell of origin. These modifications include carboxylation; HYDROXYLATION; ACETYLATION; PHOSPHORYLATION; METHYLATION; GLYCOSYLATION; ubiquitination; oxidation; proteolysis; and crosslinking and result in changes in molecular weight and electrophoretic motility.

The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.

A monosaccharide in sweet fruits and honey that is soluble in water, alcohol, or ether. It is used as a preservative and an intravenous infusion in parenteral feeding.

The aggregation of suspended solids into larger clumps.

A class of enzymes that transfers substituted phosphate groups. EC 2.7.8.

A plant genus in the family LILIACEAE (sometimes classified as Amaryllidaceae). Galanthus nivalis L. is the source of GALANTHAMINE.

Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.

A class of enzymes that catalyzes the phosphorylation of fructose in the presence of ATP. EC 2.7.1.-.

A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.

Transport proteins that carry specific substances in the blood or across cell membranes.

The outermost layer of a cell in most PLANTS; BACTERIA; FUNGI; and ALGAE. The cell wall is usually a rigid structure that lies external to the CELL MEMBRANE, and provides a protective barrier against physical or chemical agents.

A network of membrane compartments, located at the cytoplasmic side of the GOLGI APPARATUS, where proteins and lipids are sorted for transport to various locations in the cell or cell membrane.

Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.

A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)

Esters formed between the aldehydic carbon of sugars and the terminal phosphate of guanosine diphosphate.

The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.

Glycoproteins found on the membrane or surface of cells.

Serves as the biological precursor of insect chitin, of muramic acid in bacterial cell walls, and of sialic acids in mammalian glycoproteins.

A methylpentose whose L- isomer is found naturally in many plant glycosides and some gram-negative bacterial lipopolysaccharides.

A system of cisternae in the CYTOPLASM of many cells. In places the endoplasmic reticulum is continuous with the plasma membrane (CELL MEMBRANE) or outer membrane of the nuclear envelope. If the outer surfaces of the endoplasmic reticulum membranes are coated with ribosomes, the endoplasmic reticulum is said to be rough-surfaced (ENDOPLASMIC RETICULUM, ROUGH); otherwise it is said to be smooth-surfaced (ENDOPLASMIC RETICULUM, SMOOTH). (King & Stansfield, A Dictionary of Genetics, 4th ed)

Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.

Positively charged atoms, radicals or groups of atoms which travel to the cathode or negative pole during electrolysis.

Proteins prepared by recombinant DNA technology.

A MANNOSE/GLUCOSE binding lectin isolated from the jack bean (Canavalia ensiformis). It is a potent mitogen used to stimulate cell proliferation in lymphocytes, primarily T-lymphocyte, cultures.

Polyhydric alcohols having no more than one hydroxy group attached to each carbon atom. They are formed by the reduction of the carbonyl group of a sugar to a hydroxyl group.(From Dorland, 28th ed)

Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.

The parts of a macromolecule that directly participate in its specific combination with another molecule.

A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.

Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.

Phosphoric or pyrophosphoric acid esters of polyisoprenoids.

Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).

Glycoprotein molecules on the surface of B- and T-lymphocytes, that react with molecules of antilymphocyte sera, lectins, and other agents which induce blast transformation of lymphocytes.

Cell surface molecules on cells of the immune system that specifically bind surface molecules or messenger molecules and trigger changes in the behavior of cells. Although these receptors were first identified in the immune system, many have important functions elsewhere.

Separation technique in which the stationary phase consists of ion exchange resins. The resins contain loosely held small ions that easily exchange places with other small ions of like charge present in solutions washed over the resins.

The engulfing of liquids by cells by a process of invagination and closure of the cell membrane to form fluid-filled vacuoles.

Carbohydrates covalently linked to a nonsugar moiety (lipids or proteins). The major glycoconjugates are glycoproteins, glycopeptides, peptidoglycans, glycolipids, and lipopolysaccharides. (From Biochemical Nomenclature and Related Documents, 2d ed; From Principles of Biochemistry, 2d ed)

Participation of a trisaccharide-lipid in glycosylation of oviduct membrane glycoproteins. (1/2363)

Preincubation of a hen oviduct membrane preparation with UDP-Nactyl[14C]glucosamine and bacitracin, followed by incubation with GDP-mannose, leads to formation of a chloroform/methanol (2/1)-extractable glycolipid. Treatment of the lipid with mild acid results in the release of a trisaccharide shown to have the structure beta-mannosyl-N-acetylglucosamineyl-N-acetylglucosamine. Incubation of purified trisaccharide-lipid with oviduct membranes in the presence of sodium deoxycholate, Mn2+, and GDP-mannose leads to formation of a labeled glycoprotein with an apparent molecular weight of 25,000... (+info)

Mannose inhibits Arabidopsis germination via a hexokinase-mediated step. (2/2363)

Low concentrations of the glucose (Glc) analog mannose (Man) inhibit germination of Arabidopsis seeds. Man is phosphorylated by hexokinase (HXK), but the absence of germination was not due to ATP or phosphate depletion. The addition of metabolizable sugars reversed the Man-mediated inhibition of germination. Carbohydrate-mediated regulation of gene expression involving a HXK-mediated pathway is known to be activated by Glc, Man, and other monosaccharides. Therefore, we investigated whether Man blocks germination through this system. By testing other Glc analogs, we found that 2-deoxyglucose, which, like Man, is phosphorylated by HXK, also blocked germination; no inhibition was observed with 6-deoxyglucose or 3-O-methylglucose, which are not substrates for HXK. Since these latter two sugars are taken up at a rate similar to that of Man, uptake is unlikely to be involved in the inhibition of germination. Furthermore, we show that mannoheptulose, a specific HXK inhibitor, restores germination of seeds grown in the presence of Man. We conclude that HXK is involved in the Man-mediated repression of germination of Arabidopsis seeds, possibly via energy depletion. (+info)

Glycosylation of asparagine-28 of recombinant staphylokinase with high-mannose-type oligosaccharides results in a protein with highly attenuated plasminogen activator activity. (3/2363)

The properties of recombinant staphylokinase (SakSTAR) expressed in Pichia pastoris cells have been determined. The single consensus N-linked oligosaccharide linkage site in SakSTAR (at Asn28 of the mature protein) was occupied in approximately 50% of the expressed protein with high-mannose-type oligosaccharides. The majority of these glycans ranged in polymerization state from Man8GlcNAc2 to Man14GlcNAc2, with the predominant species being Man10GlcNAc2 and Man11GlcNAc2. Glycosylated SakSTAR (SakSTARg) did not differ from its aglycosyl form in its aggregation state in solution, its thermal denaturation properties, its ability to form a complex with human plasmin (hPm), the amidolytic properties of the respective SakSTAR-hPm complexes, or its ability to liberate the amino-terminal decapeptide required for formation of a functional SakSTAR-hPm plasminogen activator complex. However, this latter complex with SakSTARg showed a greatly reduced ability to activate human plasminogen (hPg) as compared with the same complex with the aglycosyl form of SakSTAR. We conclude that glycosylation at Asn28 does not affect the structural properties of SakSTAR or its ability to participate in the formation of an active enzymatic complex with hPm, but it is detrimental to the ability of the SakSTAR-hPm complex to serve as a hPg activator. This is likely due to restricted access of hPg to the active site of the SakSTARg-hPm complex. (+info)

Genetic evidence for the role of GDP-mannose in plant ascorbic acid (vitamin C) biosynthesis. (4/2363)

Vitamin C (L-ascorbic acid; AsA) acts as a potent antioxidant and cellular reductant in plants and animals. AsA has long been known to have many critical physiological roles in plants, yet its biosynthesis is only currently being defined. A pathway for AsA biosynthesis that features GDP-mannose and L-galactose has recently been proposed for plants. We have isolated a collection of AsA-deficient mutants of Arabidopsis thaliana that are valuable tools for testing of an AsA biosynthetic pathway. The best-characterized of these mutants (vtc1) contains approximately 25% of wild-type AsA and is defective in AsA biosynthesis. By using a combination of biochemical, molecular, and genetic techniques, we have demonstrated that the VTC1 locus encodes a GDP-mannose pyrophosphorylase (mannose-1-P guanyltransferase). This enzyme provides GDP-mannose, which is used for cell wall carbohydrate biosynthesis and protein glycosylation as well as for AsA biosynthesis. In addition to genetically defining the first locus involved in AsA biosynthesis, this work highlights the power of using traditional mutagenesis techniques coupled with the Arabidopsis Genome Initiative to rapidly clone physiologically important genes. (+info)

Alteration of mannose transport in fibroblasts from type I carbohydrate deficient glycoprotein syndrome patients. (5/2363)

The aim of the present study was to explore how mannose enters fibroblasts derived from a panel of children suffering from different subtypes of type I carbohydrate deficient glycoprotein syndrome: seven carbohydrate deficient glycoprotein syndrome subtype Ia (phosphomannomutase deficiency), two carbohydrate deficient glycoprotein syndrome subtype Ib (phosphomannose isomerase deficiency) and two carbohydrate deficient glycoprotein syndrome subtype Ix (not identified deficiency). We showed that a specific mannose transport system exists in all the cells tested but has different characteristics with respect to carbohydrate deficient glycoprotein syndrome subtypes. Subtype Ia fibroblasts presented a mannose uptake equivalent or higher (maximum 1.6-fold) than control cells with a D-[2-3H]-mannose incorporation in nascent N-glycoproteins decreased up to 7-fold. Compared to control cells, the mannose uptake was greatly stimulated in subtype Ib (4.0-fold), due to lower Kuptake and higher Vmax values. Subtype Ib cells showed an increased incorporation of D-[2-3H]-mannose into nascent N-glycoproteins. Subtype Ix fibroblasts presented an intermediary status with mannose uptake equivalent to the control but with an increased incorporation of D-[2-3H]-mannose in nascent N-glycoproteins. All together, our results demonstrate quantitative and/or qualitative modifications in mannose transport of all carbohydrate deficient glycoprotein syndrome fibroblasts in comparison to control cells, with a relative homogeneity within a considered subtype of carbohydrate deficient glycoprotein syndrome. These results are consistent with the possible use of mannose as a therapeutic agent in carbohydrate deficient glycoprotein syndrome Ib and Ix. (+info)

Sugars and sugar derivatives which inhibit the short-circuit current of the everted small intestine of the rat. (6/2363)

1. The short-circuit current of everted rat intestine supported on a perforated cannula proved to be stable for up to 3 hr and has been used to study competition between transportable and non-transportable sugars. 2. 4,6-O-Ethylidene-alpha-D-glucopyranose (ethylidene glucose) and 4,6-O-benzylidene-e alpha-D-glucopyranos (benzylinene glucose), two nontransportable inhibitors of the hexose transfer system in human erythrocytes, were found to reduce the short-circuit current generated by transportable sugars such as galactose or 3-O-methyl glucose. 3. These compounds were also found to reduce the basal short-circuit current established by the everted intestine in a sugar-free Krebs solution. Both types of inhibition approached saturation at the higher concentrations used. 4. Similar inhibitory properties were shown by mannose, a non-actively accumulated monosaccharide, and by the beta-disaccharides lactose and cellobiose. 5. It is suggested that this common pattern of behaviour is due to the ability of these compounds to react with the sites for active hexose transfer but without translocation by the system. The significance of the inhibition of the basal short-circuit current is briefly discussed in this context. (+info)

Transmembrane folding of the human erythrocyte anion exchanger (AE1, Band 3) determined by scanning and insertional N-glycosylation mutagenesis. (7/2363)

The human erythrocyte anion exchanger (AE1, Band 3) contains up to 14 transmembrane segments, with a single site of N-glycosylation at Asn642 in extracellular (EC) loop 4. Scanning and insertional N-glycosylation mutagenesis were used to determine the folding pattern of AE1 in the membrane. Full-length AE1, when expressed in transfected human embryonic kidney (HEK)-293 or COS-7 cells, retained a high-mannose oligosaccharide structure. Scanning N-glycosylation mutagenesis of EC loop 4 showed that N-glycosylation acceptor sites (Asn-Xaa-Ser/Thr) spaced 12 residues from the ends of adjacent transmembrane segments could be N-glycosylated. An acceptor site introduced at position 743 in intracellular (IC) loop 5 that could be N-glycosylated in a cell-free translation system was not N-glycosylated in transfected cells. Mutations designed to disrupt the folding of this loop enhanced the level of N-glycosylation at Asn743 in vitro. The results suggest that this loop might be transiently exposed to the lumen of the endoplasmic reticulum during biosynthesis but normally folds rapidly, precluding N-glycosylation. EC loop 4 insertions into positions 428, 484, 754 and 854 in EC loops 1, 2, 6 and 7 respectively were efficiently N-glycosylated, showing that these regions were extracellular. EC loop 4 insertions into positions 731 or 785 were poorly N-glycosylated, which was inconsistent with an extracellular disposition for these regions of AE1. Insertion of EC loop 4 into positions 599 and 820 in IC loops 3 and 6 respectively were not N-glycosylated in cells, which was consistent with a cytosolic disposition for these loops. Inhibitor-affinity chromatography with 4-acetamido-4'-isothiocyanostilbene-2,2'-disulphonate (SITS)-Affi-Gel was used to assess whether the AE1 mutants were in a native state. Mutants with insertions at positions 428, 484, 599, 731 and 785 showed impaired inhibitor binding, whereas insertions at positions 754, 820 and 854 retained binding. The results indicate that the folding of the C-terminal region of AE1 is more complex than originally proposed and that this region of the transporter might have a dynamic aspect. (+info)

Recombinant human interleukin-12 is the second example of a C-mannosylated protein. (8/2363)

The beta-chain of human interleukin 12 (IL-12) contains at position 319-322, the sequence Trp-x-x-Trp. In human RNase 2 this is the recognition motif for a new, recently discovered posttranslational modification, i.e., the C-glycosidic attachment of a mannosyl residue to the side chain of tryptophan. Analysis of C-terminal peptides of recombinant IL-12 (rHuIL-12) by mass spectrometry and NMR spectroscopy revealed that Trp-319beta is (partially) C-mannosylated. This finding was extended by in vitro mannosylation experiments, using a synthetic peptide derived from the same region of the protein as an acceptor. Furthermore, human B-lymphoblastoid cells, which secrete IL-12, were found to contain an enzyme that carries out the C-mannosylation reaction. This shows that nonrecombinant IL-12 is potentially C-mannosylated as well. This is only the second report on a C-mannosylated protein. However, the occurrence of the C-mannosyltransferase activity in a variety of cells and tissues, and the presence of the recognition motif in many proteins indicate that more C-mannosylated proteins may be found. (+info)

CDGs are caused by mutations in genes that code for enzymes involved in glycosylation, a process that adds sugars to proteins and lipids to form glycoproteins and glycolipids. These molecules play important roles in cell signaling, protein folding, and the immune response. Without proper glycosylation, these molecules cannot function properly, leading to a wide range of symptoms and complications.

Symptoms of CDGs can vary depending on the specific disorder and the organs affected. Common symptoms include developmental delays, intellectual disability, seizures, poor muscle tone, and liver problems. Some children with CDGs may also experience failure to thrive, diarrhea, and vomiting.

There is currently no cure for CDGs, but various treatments are available to manage the symptoms and prevent complications. These may include enzyme replacement therapy, nutritional supplements, and medications to control seizures and other symptoms. In some cases, a bone marrow transplant may be necessary to replace the defective cells with healthy ones.

The diagnosis of CDG is based on a combination of clinical symptoms, laboratory tests, and genetic analysis. Newborn screening is increasingly being used to identify CDGs in infants, allowing for early intervention and treatment.

Overall, congenital disorders of glycosylation are rare and complex conditions that require specialized care and management. With advances in medical technology and research, there is hope for improved treatments and outcomes for individuals with CDGs.

The term "mucolipidoses" was coined by the American pediatrician and medical geneticist Dr. Victor A. McKusick in the 1960s to describe this group of diseases. The term is derived from the Greek words "muco-," meaning mucus, and "-lipido-," meaning fat, and "-osis," meaning condition or disease.

There are several types of mucolipidoses, including:

1. Mucolipidosis type I (MLI): This is the most common form of the disorder and is caused by a deficiency of the enzyme galactocerebrosidase (GALC).
2. Mucolipidosis type II (MLII): This form of the disorder is caused by a deficiency of the enzyme sulfatases, which are necessary for the breakdown of sulfated glycosaminoglycans (sGAGs).
3. Mucolipidosis type III (MLIII): This form of the disorder is caused by a deficiency of the enzyme acetyl-CoA:beta-glucoside ceramide beta-glucosidase (CERBGL), which is necessary for the breakdown of glycosphingolipids.
4. Mucolipidosis type IV (MLIV): This form of the disorder is caused by a deficiency of the enzyme glucocerebrosidase (GUCB), which is necessary for the breakdown of glucocerebroside, a type of glycosphingolipid.

Mucolipidoses are usually diagnosed by measuring the activity of the enzymes involved in glycosphingolipid metabolism in white blood cells or fibroblasts, and by molecular genetic analysis to identify mutations in the genes that code for these enzymes. Treatment is typically focused on managing the symptoms and may include physical therapy, speech therapy, and other supportive care measures. Bone marrow transplantation has been tried in some cases as a potential treatment for mucolipidosis, but the outcome has been variable.

Prognosis: The prognosis for mucolipidoses is generally poor, with most individuals with the disorder dying before the age of 10 years due to severe neurological and other complications. However, with appropriate management and supportive care, some individuals with milder forms of the disorder may survive into adulthood.

Epidemiology: Mucolipidoses are rare disorders, with an estimated prevalence of 1 in 100,000 to 1 in 200,000 births. They affect both males and females equally, and there is no known geographic or ethnic predilection.

Clinical features: The clinical features of mucolipidoses vary depending on the specific type of disorder and the severity of the mutation. Common features include:

* Delayed development and intellectual disability
* Seizures
* Vision loss or blindness
* Hearing loss or deafness
* Poor muscle tone and coordination
* Increased risk of infections
* Coarsening of facial features
* Enlarged liver and spleen
* Abnormalities of the heart, including ventricular septal defect and atrial septal defect

Diagnosis: Diagnosis of mucolipidoses is based on a combination of clinical features, laboratory tests, and genetic analysis. Laboratory tests may include measurement of enzyme activity in white blood cells, urine testing, and molecular genetic analysis.

Treatment and management: There is no cure for mucolipidoses, but treatment and management strategies can help manage the symptoms and improve quality of life. These may include:

* Physical therapy to improve muscle tone and coordination
* Speech therapy to improve communication skills
* Occupational therapy to improve daily living skills
* Anticonvulsant medications to control seizures
* Supportive care to manage infections and other complications
* Genetic counseling to discuss the risk of inheritance and options for family planning.

Prognosis: The prognosis for mucolipidoses varies depending on the specific type and severity of the condition. In general, the prognosis is poor for children with more severe forms of the disorder, while those with milder forms may have a better outlook. With appropriate management and supportive care, some individuals with mucolipidoses can lead relatively normal lives, while others may require ongoing medical care and assistance throughout their lives.

Examples of inborn errors of carbohydrate metabolism include:

1. Phosphofructokinase (PFK) deficiency: This is a rare genetic disorder that affects the body's ability to break down glucose-6-phosphate, a type of sugar. Symptoms can include seizures, developmental delays, and metabolic acidosis.
2. Galactosemia: This is a group of genetic disorders that affect the body's ability to process galactose, a type of sugar found in milk and other dairy products. Untreated, galactosemia can lead to serious health problems, including liver disease, kidney damage, and cognitive impairment.
3. Glycogen storage disease type II (GSDII): This is a rare genetic disorder that affects the body's ability to store and use glycogen, a complex carbohydrate found in the liver and muscles. Symptoms can include low blood sugar, fatigue, and muscle weakness.
4. Pompe disease: This is a rare genetic disorder that affects the body's ability to break down glycogen. Symptoms can include muscle weakness, breathing problems, and heart problems.
5. Mucopolysaccharidoses (MPS): These are a group of genetic disorders that affect the body's ability to break down sugar molecules. Symptoms can include joint stiffness, developmental delays, and heart problems.

Inborn errors of carbohydrate metabolism can be diagnosed through blood tests, urine tests, and other diagnostic procedures. Treatment depends on the specific disorder and may involve a combination of dietary changes, medication, and other therapies.

... mannose to prevent or treat UTIs. Mannose differs from glucose by inversion of the C-2 chiral center. Mannose displays a 4 C 1 ... α-Mannosidase Mannose receptor Mannan oligosaccharide-based nutritional supplements Rhamnose, 6-deoxy-L-mannose PTS Mannose- ... Mannose is a sugar monomer of the aldohexose series of carbohydrates. It is a C-2 epimer of glucose. Mannose is important in ... Mannose is not an essential nutrient; it can be produced in the human body from glucose, or converted into glucose. Mannose ...

https://en.wikipedia.org/wiki/Mannose

Despite the similarities in mannose-binding between the mannose receptor and MBL, these differences suggest that mannose- ... As opposed to macrophages that use the mannose receptors for phagocytosis of particulate matter >200 nm, the mannose receptor ... binding by the mannose receptor evolved separately to that of other C-type lectins. Individually, the CRDs bind mannose with ... The mannose receptor is the only member of the family in which this domain is functional. The fibronectin type II repeat domain ...

https://en.wikipedia.org/wiki/Mannose_receptor

In enzymology, a mannose isomerase (EC 5.3.1.7) is an enzyme that catalyzes the chemical reaction D-mannose ⇌ {\displaystyle \ ... The systematic name of this enzyme class is D-mannose aldose-ketose-isomerase. Other names in common use include D-mannose ... This enzyme participates in fructose and mannose metabolism. Palleroni NJ, Doudoroff M (January 1956). "Mannose isomerase of ... rightleftharpoons } D-fructose Hence, this enzyme has one substrate, D-mannose, and one product, D-fructose. This enzyme ...

https://en.wikipedia.org/wiki/Mannose_isomerase

The enzyme dolichylphosphate-mannose phosphodiesterase (EC 3.1.4.49) catalyzes the reaction dolichyl β-D-mannosyl phosphate + ... H2O ⇌ {\displaystyle \rightleftharpoons } dolichyl phosphate + D-mannose This enzyme belongs to the family of hydrolases, ...

https://en.wikipedia.org/wiki/Dolichylphosphate-mannose_phosphodiesterase

I-cell disease Insulin-like growth factor 2 receptor Mannose Mannose 1-phosphate Alberts, Bruce; et al. (2002). Molecular ... Mannose-6-phosphate (M6P) is a molecule bound by lectin in the immune system. M6P is converted to fructose 6-phosphate by ... Mannose-6-Phosphate+Receptor at the US National Library of Medicine Medical Subject Headings (MeSH) Role of M6P in protein ... There, the M6P moiety is recognized and bound by mannose 6-phosphate receptor (MPR) proteins at pH 6.5-6.7. The M6P-tagged ...

https://en.wikipedia.org/wiki/Mannose_6-phosphate

GDP-mannose is essential in eukaryotes. GDP-mannose is produced from GTP and mannose-6-phosphate by the enzyme mannose-1- ... Guanosine diphosphate mannose or GDP-mannose is a nucleotide sugar that is a substrate for glycosyltransferase reactions in ... One of the enzymes from the family of nucleootidyl-transferases, GDP-Mannose Pyrophosphorylase (GDP-MP) is an pervasive enzyme ... Pomel, Sébastien; Mao, Wei; Ha-Duong, Tâp; Cavé, Christian; Loiseau, Philippe M. (2019-05-31). "GDP-Mannose Pyrophosphorylase: ...

https://en.wikipedia.org/wiki/Guanosine_diphosphate_mannose

... and mannose-6-phosphate (M6P). Mannose-6-phosphate isomerase may also enable the synthesis of GDP-mannose in eukaryotic ... Because mannose and glucose are stereoisomers at C2, which is crucial to the mechanism for both enzymes, PMI must allow extra ... Mannose-6 phosphate isomerase (MPI), alternately phosphomannose isomerase (PMI) (EC 5.3.1.8) is an enzyme which facilitates the ... MPI must convert an aldose (mannose) to a ketose (fructose), in addition to opening and closing the rings for these sugars. In ...

https://en.wikipedia.org/wiki/Mannose_phosphate_isomerase

... diphospho-D-mannose, pyrophosphorylase), GDP-mannose pyrophosphorylase, guanosine 5'-diphospho-D-mannose pyrophosphorylase, ... GDP-mannose Thus, the two substrates of this enzyme are GTP and alpha-D-mannose 1-phosphate, whereas its two products are ... alpha-D-mannose-1-phosphate guanylyltransferase. Other names in common use include GTP-mannose-1-phosphate guanylyltransferase ... and mannose 1-phosphate guanylyltransferase (guanosine triphosphate). This enzyme participates in fructose and mannose ...

https://en.wikipedia.org/wiki/Mannose-1-phosphate_guanylyltransferase

In enzymology, a GDP-mannose 6-dehydrogenase (EC 1.1.1.132) is an enzyme that catalyzes the chemical reaction GDP-D-mannose + 2 ... and guanosine diphospho-D-mannose dehydrogenase. This enzyme participates in fructose and mannose metabolism. This protein may ... The systematic name of this enzyme class is GDP-D-mannose:NAD+ 6-oxidoreductase. Other names in common use include guanosine ... 2 H+ The 3 substrates of this enzyme are GDP-D-mannose, NAD+, and H2O, whereas its 3 products are GDP-D-mannuronate, NADH, and ...

https://en.wikipedia.org/wiki/GDP-mannose_6-dehydrogenase

... mannose 6-phosphate) or phosphodiester (Man-phosphate-GlcNAc) Number of mannose 6-phosphate tags Location of the mannose 6- ... Domains 3, 5 and 9 have been found to bind to mannose 6-phosphate. Domains 3 and 9 can bind to mannose 6-phosphate with high ... Each monomer forms a 9 stranded β-barrel which can bind to a single mannose 6-phosphate residue. The CI-MPR and CD-MPR bind ... Mannose 6-phosphate receptors bind newly synthesized lysosomal hydrolases in the trans-Golgi network (TGN) and deliver them to ...

https://en.wikipedia.org/wiki/Mannose_6-phosphate_receptor

... is a protein that in humans is encoded by the MRC1 gene. The recognition of complex carbohydrate ... "Entrez Gene: Mannose receptor C-type 1". Retrieved 2018-10-15. DesJardin LE, Kaufman TM, Potts B, Kutzbach B, Yi H, Schlesinger ... Le Cabec V, Emorine LJ, Toesca I, Cougoule C, Maridonneau-Parini I (June 2005). "The human macrophage mannose receptor is not a ... The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and ...

https://en.wikipedia.org/wiki/Mannose_receptor_C-type_1

The systematic name of this enzyme class is GDP-mannose 3,5-epimerase. Other names in common use include GDP-D-mannose:GDP-L- ... In enzymology, a GDP-mannose 3,5-epimerase (EC 5.1.3.18) is an enzyme that catalyzes the chemical reaction GDP-mannose ⇌ {\ ... GDP-mannose, and two products, GDP-L-galactose and GDP-L-gulose Since only GDP-L-gulose (the C5-epimer of GDP-D-mannose) was ... Gevaert O, Van Overtveldt S, Da Costa M, Beerens K, Desmet T (2020). "GDP-altrose as novel product of GDP-mannose 3,5-epimerase ...

https://en.wikipedia.org/wiki/GDP-mannose_3,5-epimerase

The chemical reaction of GDP-Mannose 4, 6-Dehydratase is as shown: GDP-mannose ↔ GDP-4-dehydro-6-deoxy-D-mannose + H2O The ... GDP-D-mannose dehydratase, GDP-D-mannose 4,6-dehydratase, GMD, and GDP-mannose 4,6-hydro-lyase. The enzyme is a part of the GDP ... GDP-D-mannose dehydratase, GDP-D-mannose 4,6-dehydratase, Gmd, and GDP-mannose 4,6-hydro-lyase. This enzyme participates in ... The enzyme GDP-Mannose 4, 6-Dehydratase is only present in one pathway that we know of. This pathway is the GDP-mannose- ...

https://en.wikipedia.org/wiki/GDP-mannose_4,6-dehydratase

GDP mannose phosphorylase Mannose 1-phosphate (guanosine diphosphate) guanylyltransferase GDP mannose phosphorylase GDP-mannose ... GDP-mannose Thus, the two substrates of this enzyme are GDP and alpha-D-mannose 1-phosphate, whereas its two products are ... alpha-D-mannose-1-phosphate guanylyltransferase. This enzyme participates in fructose and mannose metabolism. ... In enzymology, a mannose-1-phosphate guanylyltransferase (GDP) (EC 2.7.7.22) is an enzyme that catalyzes the chemical reaction ...

https://en.wikipedia.org/wiki/Mannose-1-phosphate_guanylyltransferase_(GDP)

The mannose porter of Escherichia coli, for example, can transport and phosphorylate glucose, mannose, fructose, glucosamine, N ... The PTS Mannose-Fructose-Sorbose (Man) Family (TC# 4.A.6) is a group of multicomponent PTS systems that are involved in sugar ... As of this edit, this article uses content from "4.A.6 The PTS Mannose-Fructose-Sorbose (Man) Family", which is licensed in a ... Huber, F.; Erni, B. (1996-08-01). "Membrane topology of the mannose transporter of Escherichia coli K12". European Journal of ...

https://en.wikipedia.org/wiki/PTS_Mannose-Fructose-Sorbose_Family

Other names in common use include NADPH-dependent mannose 6-phosphate reductase, mannose-6-phosphate reductase, 6- ... In enzymology, a mannose-6-phosphate 6-reductase (EC 1.1.1.224) is an enzyme that catalyzes the chemical reaction D-mannitol 1- ... and NADPH-mannose-6-P reductase. Rumpho ME, Edwards GE, Loescher WH (1983). "A pathway for photosynthetic carbon flow to ... whereas its 3 products are D-mannose 6-phosphate, NADPH, and H+. This enzyme belongs to the family of oxidoreductases, ...

https://en.wikipedia.org/wiki/Mannose-6-phosphate_6-reductase

The systematic name of this enzyme class is dolichyl-phosphate-D-mannose:protein O-D-mannosyltransferase. Other names in common ... In enzymology, a dolichyl-phosphate-mannose-protein mannosyltransferase (EC 2.4.1.109) is an enzyme that catalyzes the chemical ... the two substrates of this enzyme are dolichyl phosphate D-mannose and protein, whereas its two products are dolichyl phosphate ... "Yeast mannosyl transferases requiring dolichyl phosphate and dolichyl phosphate mannose as substrate. Partial purification and ...

https://en.wikipedia.org/wiki/Dolichyl-phosphate-mannose-protein_mannosyltransferase

... are serine proteases involved in the complement system. Types include: MASP1 ... "The emerging roles of mannose-binding lectin-associated serine proteases (MASPs) in the lectin pathway of complement and beyond ... "Molecular characterization of a novel serine protease involved in activation of the complement system by mannose-binding ...

https://en.wikipedia.org/wiki/Mannose-binding_protein-associated_serine_protease

cation-dependent+mannose-6-phosphate+receptor at the US National Library of Medicine Medical Subject Headings (MeSH) v t e ( ... Kölsch H, Ptok U, Majores M, Schmitz S, Rao ML, Maier W, Heun R (2004). "Putative association of polymorphism in the mannose 6- ... The CD-MPR is one of two transmembrane proteins that bind mannose-6-phosphate (M6P) tags on acid hydrolase precursors in the ... Ghosh P, Dahms NM, Kornfeld S (March 2003). "Mannose 6-phosphate receptors: new twists in the tale". Nat. Rev. Mol. Cell Biol. ...

https://en.wikipedia.org/wiki/Cation-dependent_mannose-6-phosphate_receptor

GDP-mannose:cellobiosyl-diphosphopolyprenol+alpha-mannosyltransferase at the US National Library of Medicine Medical Subject ... GDP-mannose:cellobiosyl-diphosphopolyprenol alpha-mannosyltransferase (EC 2.4.1.252, GumH, AceA, alpha1,3-mannosyltransferase ... Petroni EA, Ielpi L (August 1996). "Isolation and nucleotide sequence of the GDP-mannose:cellobiosyl-diphosphopolyprenol alpha- ... This enzyme catalyses the following chemical reaction GDP-mannose + D-Glc-beta-(1->4)-Glc-alpha-1-diphospho-ditrans,octacis- ...

https://en.wikipedia.org/wiki/GDP-mannose:cellobiosyl-diphosphopolyprenol_alpha-mannosyltransferase

GDP-4-dehydro-6-deoxy-D-mannose + NAD(P)H + H+ The 3 substrates of this enzyme are GDP-6-deoxy-D-mannose, NAD+, and NADP+, ... In enzymology, a GDP-4-dehydro-6-deoxy-D-mannose reductase (EC 1.1.1.281) is an enzyme that catalyzes the chemical reaction GDP ... The systematic name of this enzyme class is GDP-6-deoxy-D-mannose:NAD(P)+ 4-oxidoreductase (D-rhamnose-forming). Other names in ... This enzyme participates in fructose and mannose metabolism. Messner P; Graninger, M; Adam, G; Puchberger, M; Kosma, P; Zayni, ...

https://en.wikipedia.org/wiki/GDP-4-dehydro-6-deoxy-D-mannose_reductase

... the core mannose of high-mannose oligosaccharides produced by Dictyostelium discoideum The activity of the intersecting mannose ... High-mannose-oligosaccharide+beta-1,4-N-acetylglucosaminyltransferase at the US National Library of Medicine Medical Subject ... High-mannose-oligosaccharide beta-1,4-N-acetylglucosaminyltransferase (EC 2.4.1.197), uridine diphosphoacetylglucosamine- ... high-mannose-oligosaccharide beta-1,4-N-acetylglucosaminyltransferase) is an enzyme with systematic name UDP-N-acetyl-D- ...

https://en.wikipedia.org/wiki/High-mannose-oligosaccharide_beta-1,4-N-acetylglucosaminyltransferase

Fischer, Emil; Hirschberger, Josef (1 January 1889). "Ueber Mannose. II". Berichte der Deutschen Chemischen Gesellschaft. 22 (1 ...

https://en.wikipedia.org/wiki/Enantioselective_synthesis

Another potential characterization of the CLRs can be into mannose receptors and asialoglycoprotein receptors. The mannose ... Specifically, mannose binding triggers recruitment of MBL-associated serine proteases (MASPs). The serine proteases activate ... It recognizes and binds to repeated mannose units on the surfaces of infectious agents and its activation triggers endocytosis ... Dommett RM, Klein N, Turner MW (September 2006). "Mannose-binding lectin in innate immunity: past, present and future". Tissue ...

https://en.wikipedia.org/wiki/Pattern_recognition_receptor

"Mannose-binding lectin deficiency". Genetics Home Reference. U.S. National Library of Medicine. v t e (Articles with short ...

https://en.wikipedia.org/wiki/MBL_deficiency

... cation-independent mannose-6-phosphate receptor; mannose receptor of macrophages; 180 Kd secretory phospholipase A2 receptor; ... Drickamer K, Taylor ME, Conary JT, Lennartz MR, Stahl PD (1990). "Primary structure of the mannose receptor contains multiple ... Kornfeld S (1992). "Structure and function of the mannose 6-phosphate/insulinlike growth factor II receptors". Annu. Rev. ...

https://en.wikipedia.org/wiki/Fibronectin_type_II_domain

Irvine, James Colquhoun; Moodie, Agnes Marion (1905). "CXLIV.-The alkylation of mannose". J. Chem. Soc., Trans. 87: 1462-1468. ...

https://en.wikipedia.org/wiki/Agnes_Marion_Moodie

... cation-independent mannose-6-phosphate receptor) and CD-MPR (cation-dependent mannose-6-phosphate receptor). In eukaryotes, O- ... Five mannose residues are then added to this structure. At this point, the partially finished core glycan is flipped across the ... The modification of an N-linked glycan with a mannose-6-phosphate residue serves as a signal that the protein to which this ... This core structure of N-linked glycans, thus, consists of 14 residues (3 glucose, 9 mannose, and 2 N-acetylglucosamine). Image ...

https://en.wikipedia.org/wiki/Glycan

... mannose receptor), CD301, CD103. The mesoderm gives rise to myeloid progenitor cells, which further differentiate into ...

https://en.wikipedia.org/wiki/Pancreatic_islet_macrophage

This enzyme is responsible for the interconversion of mannose-6-phosphate and mannose-1-phosphate, and its deficiency leads to ... the enzyme responsible for the conversion of mannose-6-phosphate into mannose-1-phosphate.[citation needed] The specific ... Mannose supplementation relieves the symptoms in MPI-CDG for the most part, even though the hepatic fibrosis may persist. ... Not all structures are fully modified, some remain as high-mannose structures, others as hybrids (one unmodified Man branch and ...

https://en.wikipedia.org/wiki/Congenital_disorder_of_glycosylation

Mannose-binding lectin deficiency is a condition that affects the immune system. Explore symptoms, inheritance, genetics of ... Functional mannose-binding lectins are made up of two to six protein groups called trimers, which are each composed of three of ... The role of mannose-binding lectin in health and disease. Mol Immunol. 2003 Nov;40(7):423-9. doi: 10.1016/s0161-5890(03)00155-x ... Mannose-binding lectin plays an important role in the bodys immune response by attaching to foreign invaders such as bacteria ...

https://medlineplus.gov/genetics/condition/mannose-binding-lectin-deficiency

mouse beta-mannosidase bound to beta-D-mannose (MANBA) ... mouse beta-mannosidase bound to beta-D-mannose (MANBA). *PDB ... Here, we present the first structures of a mammalian β-mannosidase in both the apo- and mannose-bound forms. The structure is ... β-Mannosidase is a lysosomal enzyme from the glycosyl hydrolase family 2 that cleaves the single β(1-4)-linked mannose at the ... β-Mannosidase is a lysosomal enzyme from the glycosyl hydrolase family 2 that cleaves the single β(1-4)-linked mannose at the ...

https://www.rcsb.org/structure/6ddu

Mannose-binding lectin (MBL), a mammalian lectin, is a pattern recognition molecule of the innate immune system and recognizes ... Fraser, I.P., Koziel, H., Ezekowitz, R.A. (1998) The serum mannose-binding protein and the macrophage mannose receptor are pat- ... Enhancement of complement activation and opsonophagocytosis by complexes of mannose-binding lectin with mannose-binding lectin- ... Mannose-binding lectin (MBL), a mammalian lectin, is a pattern recognition molecule of the innate immune system and recognizes ...

https://www.scirp.org/journal/paperinformation.aspx?paperid=7716

Cookies help us deliver our services. By using our services, you agree to our use of cookies. ...

https://www.wikidoc.org/index.php/Special:WhatLinksHere/Mannose

D-Mannose, 500 mg, 30 capsules Supports Urinary Tract Health *Dietary Supplement ... D-Mannose supports the health of the entire urinary tract: the urethra, bladder, ureter, renal pelvis and the renal parenchyma ... Sorry, D-Mannose Special has been discontinued and is no longer available. Please check our related products, categories, or ... D-Mannose is a monosaccharide hexose sugar, naturally found in some trees, berries and fruits, such as cranberry. It ...

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Bretthauer, R.K.; W.S. 1974: Transfer of mannose from dolichol mono phosphate mannose to yeast glyco protein acceptors Lee, E Y ... mannose synthase catalyzes the formation of Dolichol-phosphate-mannose from Dolichol-phosphate and GDP-mannose. Analysis of the ... Bretthauer, R.K.; Wu, S.; Irwin, W.E. 1973: Enzymatic transfer of mannose from guanosine diphosphate mannose to dolichol ... 2015: Dolichol phosphate mannose synthase from the pathogenic yeast Candida albicans is a multimeric enzyme Biochimica et ...

https://eurekamag.com/research/041/839/041839913.php

The association between selected mannose-binding lectin (MBL) genotype polymorphisms and Wuchereria bancrofti infection status ... Mannose-binding lectin and its genetic variants. Genes Immun 7: 85-94. ... Mannose-binding lectin is a disease modifier in clinical malaria and may function as opsonin for Plasmodium falciparum-infected ... Mannose-binding lectin is a disease modifier in clinical malaria and may function as opsonin for Plasmodium falciparum. - ...

https://www.ajtmh.org/abstract/journals/tpmd/82/1/article-p115.xml?rskey=BTXDWP&result=2

6 Probiotics Strains, Organic Prebiotics, D-Mannose and Cranberry. ... D-Mannose and proanthocyanadins from Pro Cran dOr™ - a pure, concentrated whole cranberry fruit powder - show evidence of the ... D-mannose is a monosaccharide (sugar) that naturally occurs in fruits including apples, blueberries, and cranberries. In ... 9. Altarac S, Papeš D. Use of D-mannose in Prophylaxis of Recurrent Urinary Tract Infections (UTIs) in Women. BJU Int. 2014; ...

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Expression of the two mannose 6-phosphate receptors is spatially and temporally different during mouse embryogenesis U. Matzner ... Furthermore, the larger of the two receptors with an apparent MT of 300 ×103 (MPR300) mediates the endocjlosis of mannose 6- ... The receptors recognize mannose 6-phosphate residues which are specifically added to lysosomal enzymes during their passage ... U. Matzner, K. Von Figura, R. Pohlmann; Expression of the two mannose 6-phosphate receptors is spatially and temporally ...

https://journals.biologists.com/dev/article/114/4/965/37247/Expression-of-the-two-mannose-6-phosphate

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First small molecular inhibitors of T. brucei dolicholphosphate mannose synthase (DPMS), a validated drug target in African ... brucei dolicholphosphate mannose synthase (DPMS), a validated drug target in African sleeping sickness. Bioorganic & Medicinal ...

https://ueaeprints.uea.ac.uk/id/eprint/56197/

One unit is defined as the amount of enzyme that catalyzes the formation of 1 μmol of GDP-Man from Mannose-1-P and GTP per ... E. coli recombinant GDP-Mannose pyrophosphorylase from Pyrococcus furiosus. E.C. No.: 2.7.7.13. MW: -. Purity: min 95% by SDS- ...

http://www.chemilyglycoscience.com/product/manpp/

mannose-1-phosphate guanylyltransferase (GDP) activity. GO:0010471. GDP-galactose:mannose-1-phosphate guanylyltransferase ... mannose-phosphate guanylyltransferase activity. id: GO:0008905. name: mannose-phosphate guanylyltransferase activity. namespace ... Description: Catalysis of the transfer of a phosphate group from GTP or GDP to a mannose molecule. ...

https://networks.systemsbiology.net/function/GO:0008905/

Solaray D-Mannose with CranActin from Solaray is a dietary supplement designed to support urinary health with natural D-Mannose ... D-Mannose with CranActin from Solaray is a dietary supplement designed to support urinary health with natural D-Mannose and ...

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D-Mannose & Cranberry Extract Capsules , Complete UT Health Harvest Naturals D-Mannose & Cranberry Extract Capsules , Complete ... D-Mannose: D-Mannose is a type of sugar that occurs naturally in some plants in starch and is mainly found in cranberries. It ... Decrease Quantity of D-Mannose & Cranberry Extract Capsules , Complete UT Health Increase Quantity of D-Mannose & Cranberry ... D-Mannose works by sticking to E. Coli bacteria in the urinary tract and removing it from the body through urination, commonly ...

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D-mannose is a naturally occurring simple sugar that your body utilizes to help cleanse the urinary tract and maintain a ... Clinical studies have demonstrated that, when taken regularly, D-mannose promotes normal urinary tract function by cleansing ... NOWs D-Mannose veg capsules deliver the convenience of a pill delivery form. ... Now D-Mannose 500mg. NOWs D-Mannose veg capsules deliver the convenience of a pill delivery form. D-mannose is a naturally ...

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To study the effect of an injection of Pseudomonas aeruginosa mannose-sensitive hemagglutinin (PA-MSHA) on inflammation and ... Regulatory effect of Pseudomonas aeruginosa mannose-sensitive hemagglutinin on inflammatio Regulatory effect of Pseudomonas ... Pseudomonas aeruginosa mannose-sensitive hemagglutinin; immunomodulator; inflammation; lymphocyte subsets; percutaneous ... aeruginosa mannose-sensitive hemagglutinin on inflammation and immune function in percutaneous nephrolithotomy patients with ...

https://pesquisa.bvsalud.org/portal/resource/pt/mdl-37377966

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Curated sequence O07563: Glucose/mannose transporter GlcP; Glucose/mannose:H(+) symporter. Glucose/Mannose/Xylose: H+ symporter ... Finding step glcP for D-mannose catabolism in Pseudomonas simiae WCS417. No candidates for glcP: mannose:H+ symporter. GapMind ...

https://papers.genomics.lbl.gov/cgi-bin/gapView.cgi?orgs=orgsFit&set=carbon&orgId=FitnessBrowser__WCS417&path=mannose&step=glcP

The broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2G12 recognizes a cluster of alpha1->2 mannose ...

https://www.lji.org/publication-type/the-broadly-neutralizing-anti-human-immunodeficiency-virus-type-1-antibody-2g12-recognizes-a-cluster-of-alpha1-2-mannose-residues-on-the-outer-face-of-gp120/

The antibody pair provided in this kit recognizes mouse MBL-2 /Mannose Binding Protein C. ...

https://www.sigmaaldrich.id/id_en/rab0827-1kt-ph

D-Mannose for UTI is a popular supplement and treatment doses vary from 0.5 to1 teaspoon with a glass of water. You should wait ...

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all natural and safe supplement to be taken contains of d mannose and cranberry pills, this ingredients are known to be used on ... ON THE ADVICE FROM MY DR., I BOUGHT THIS D-MANNOSE BECAUSE IT HAS 27OOMGOF D-MANNOSE. I SUFFER FROM UTIS AND SO FAR I HAVE NOT ... Our highly powerful D-Mannose capsules combine the healthy properties of D-mannose, Cranberry, Hibiscus flower, and Dandelion ... SUPPORTS URINARY TRACT HEALTH: Our D-mannose supports the health of the entire urinary tract including the urethra, bladder, ...

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D-Mannose. 500 mg. Commonly Available Strength. Echinacea. 400 mg. Most Commonly Reported Strength. ...

https://wwwn.cdc.gov/Nchs/Nhanes/2013-2014/DSQTOT_H.htm

The role of the innate immune protein mannose-binding lectin (MBL) in host defence against severe respiratory infection remains ... Mannose-binding lectin genotypes: lack of association with susceptibility to thoracic empyema. ... BACKGROUND: The role of the innate immune protein mannose-binding lectin (MBL) in host defence against severe respiratory ... Mannose-binding lectin genotypes: lack of association with susceptibility to thoracic empyema. ...

https://www.expmedndm.ox.ac.uk/publications/48453

Rat mannose protein A (H189V) complexed with Man-a13-Man ... MANNOSE-BINDING PROTEIN A: ABC. SMTL:PDB. SMTL Chain Id:. PDB ... Rat mannose protein A (H189V) complexed with Man-a13-Man Coordinates. PDB Format Method. X-RAY DIFFRACTION 1.90 Å. Oligo State ... Ng, K.K. et al., Orientation of bound ligands in mannose-binding proteins. Implications for multivalent ligand recognition. J. ...

https://swissmodel.expasy.org/templates/1kwz

Our D-Mannose cranberry capsules use only natural ingredients, Purest Vantage D-Mannose is the obvious choice. (purestvantage.com)
NOW's D-Mannose veg capsules deliver the convenience of a pill delivery form. (waterbug.ca)
Click Buy Now below to get UT Answer Cranberry with D-Mannose, 90 Vegetarian Capsules, Nature's Answer. (dailyhealthexchange.com)
Purchase UT Answer Cranberry with D-Mannose, 90 Vegetarian Capsules, Nature's Answer from VitaSprings.com through links and I may recieve a commission. (dailyhealthexchange.com)
Our highly powerful D-Mannose capsules combine the healthy properties of D-mannose, Cranberry, Hibiscus flower, and Dandelion root extract to help flush out toxins, cleanse the urinary tract, and maintain a healthy bladder lining. (viva-nutra.com)
Contains 120 capsules - 2000mg of D-mannose, 300mg of Cranberry Juice Powder, 200mg of Hibiscus Flower Extract, and 200mg of Dandelion Root Extract. (viva-nutra.com)

D-Mannose supports the health of the entire urinary tract: the urethra, bladder, ureter, renal pelvis and the renal parenchyma. (baar.com)
D-Mannose and proanthocyanadins from Pro Cran d'Or™ - a pure, concentrated whole cranberry fruit powder - show evidence of the ability to inhibit the adherence of E. coli bacteria in the urinary tract. (physicianschoice.com)
As part of a balanced response, a physician may suggest the use of D Mannose to help a healthy urinary tract expel unwanted organisms. (purestvantage.com)
D-Mannose is a type of sugar that has been shown to help prevent UTIs by sticking to harmful bacteria and flushing them out of the urinary tract. (sproutsupps.com)
Complete with Vitamin C, Vitamin B6, D-Mannose, Cranberry 4:1 Extract, Uva Ursi, and Dandelion Extract, Complete UT Health is designed to promote urinary tract health with antioxidants. (hrsupplements.com)
D-Mannose works by sticking to E. Coli bacteria in the urinary tract and removing it from the body through urination, commonly used as a preventative measure for urinary tract infections. (hrsupplements.com)
D-mannose is a naturally occurring simple sugar that your body utilizes to help cleanse the urinary tract and maintain a healthy bladder lining. (waterbug.ca)
Clinical studies have demonstrated that, when taken regularly, D-mannose promotes normal urinary tract function by cleansing and maintaining the health of the bladder lining. (waterbug.ca)
Regulatory effect of Pseudomonas aeruginosa mannose-sensitive hemagglutinin on inflammation and immune function in percutaneous nephrolithotomy patients with upper urinary tract calculi complicated with infection. (bvsalud.org)
To study the effect of an injection of Pseudomonas aeruginosa mannose -sensitive hemagglutinin (PA-MSHA) on inflammation and immune function in patients with upper urinary tract calculi complicated by infection who have undergone percutaneous nephrolithotomy . (bvsalud.org)

Mannose-binding lectin deficiency is a condition that affects the immune system. (medlineplus.gov)
People with mannose-binding lectin deficiency can develop infections of the upper respiratory tract and other body systems. (medlineplus.gov)
Infants and young children with mannose-binding lectin deficiency seem to be more susceptible to infections than affected adults, but adults can also develop recurrent infections. (medlineplus.gov)
Relatively common mutations in the MBL2 gene can lead to mannose-binding lectin deficiency. (medlineplus.gov)
Researchers believe that a number of factors, including other genetic and environmental factors, are involved in the development of mannose-binding lectin deficiency and susceptibility to infection. (medlineplus.gov)
The inheritance pattern of mannose-binding lectin deficiency is unclear. (medlineplus.gov)
It is important to note that people inherit an increased risk of developing mannose-binding lectin deficiency, not the condition itself. (medlineplus.gov)

Functional mannose-binding lectins are made up of two to six protein groups called trimers, which are each composed of three of the protein pieces (subunits) produced from the MBL2 gene. (medlineplus.gov)
Mutations in the MBL2 gene can reduce the production of the mannose-binding lectin subunit or eliminate the subunit's ability to assemble into functional mannose-binding lectin. (medlineplus.gov)
However, not everyone with a change in the MBL2 gene has decreased levels of mannose-binding lectin, and not everyone with decreased protein levels is prone to infection. (medlineplus.gov)
Mannose-binding lectin 2 (MBL2) gene polymorphism in asthma and atopy among adults. (cdc.gov)
Mannose-binding lectin concentrations, MBL2 polymorphisms, and susceptibility to respiratory tract infections in young men. (cdc.gov)

Here, we present the first structures of a mammalian β-mannosidase in both the apo- and mannose-bound forms. (rcsb.org)
Mannose-binding lectin (MBL), a mammalian lectin, is a pattern recognition molecule of the innate immune system and recognizes carbo-hydrates that are exposed on pathogens. (scirp.org)
Mammalian cells express two mannose 6-phosphate receptors, MPR46 and MPR300, both of which mediate the targeting of lysosomal enzymes to lysosomes. (biologists.com)

Mannose-binding lectin genotypes: lack of association with susceptibility to thoracic empyema. (ox.ac.uk)
Cells lacking mannose receptors showed no susceptibility to the conjugate treatment. (cdc.gov)

The receptors recognize mannose 6-phosphate residues which are specifically added to lysosomal enzymes during their passage through the Golgi apparatus. (biologists.com)
2 mannose residues on the outer face of gp120. (lji.org)
The broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2G12 recognizes a cluster of alpha1->2 mannose residues on the outer face of gp120. (lji.org)

D-Mannose is a monosaccharide hexose sugar, naturally found in some trees, berries and fruits, such as cranberry. (baar.com)
D-mannose is a monosaccharide (sugar) that naturally occurs in fruits including apples, blueberries, and cranberries. (physicianschoice.com)

Catalysis of the transfer of a phosphate group from GTP or GDP to a mannose molecule. (systemsbiology.net)

ProCran is a potent, pure powder made from cranberry extract - an effective accompaniment to D-Mannose in helping prevent UTIs. (physicianschoice.com)
This incredible supplement combines the powerful benefits of two natural extracts, D-Mannose and Cranberry, to give you a one-two punch against UTIs. (sproutsupps.com)
Start fighting UTIs the natural way with D-Mannose Cranberry + today! (sproutsupps.com)
E. coli bacteria are responsible for causing 90% of UTIs and are not easy to get rid of unless through intervention by our healthy D-mannose punch. (viva-nutra.com)

Two MPRs are known, both of which mediate the transport of newly synthesized mannose 6-phosphate-containing ligands from the Golgi apparatus to prelysosomal structures of the endocytic pathway. (biologists.com)
Furthermore, the larger of the two receptors with an apparent M T of 300 ×10 3 (MPR300) mediates the endocjlosis of mannose 6-phosphate-containing ligands, while the smaller of the two receptors with an apparent M r of 46 ×10 3 (MPR46) mediates the secretion of part of its ligands. (biologists.com)
Orientation of bound ligands in mannose-binding proteins. (expasy.org)

Mannose binding lectin gene polymorphisms and asthma. (cdc.gov)
Mannose-binding lectin gene polymorphisms in infants with bronchiolitis and post-bronchiolitis wheezing. (cdc.gov)
Mannose-binding lectin 2 gene polymorphisms and predisposition to allergic bronchial asthma in a western Romanian children population: an observational study. (cdc.gov)

E. Coli is responsible for 90% of all UTI's, making D-Mannose an integral supplement for those that suffer from chronic UTI's. (hrsupplements.com)

This unexpected complementary expression pattern points to specific functions of the two mannose 6-phosphate receptors during mouse embryogenesis. (biologists.com)
Mannose 6-phosphate receptors (MPRs) mediate the targeting of newly synthesized soluble lysosomal enzymes. (biologists.com)

People with this condition have low levels (deficiency) of an immune system protein called mannose-binding lectin in their blood. (medlineplus.gov)
This gene provides instructions for making a protein that assembles into a complex called mannose-binding lectin. (medlineplus.gov)
A decrease in the availability of the normal subunit protein may lead to a reduction of the functional mannose-binding lectin in blood. (medlineplus.gov)
The antibody pair provided in this kit recognizes mouse MBL-2 /Mannose Binding Protein C. (sigmaaldrich.id)
BACKGROUND: The role of the innate immune protein mannose-binding lectin (MBL) in host defence against severe respiratory infection remains controversial. (ox.ac.uk)

Additionally, in contrast to most other ligand-bound β-mannosidases from bacterial and fungal sources where bound sugars were in a boat-like conformation, we find the mannose in the chair conformation. (rcsb.org)

Mannose-binding lectin plays an important role in the body's immune response by attaching to foreign invaders such as bacteria, viruses, or yeast and turning on (activating) the complement system . (medlineplus.gov)
Mannose-binding lectin can also stimulate special immune cells to engulf and break down the attached pathogen. (medlineplus.gov)

D-Mannose has clearly proven its worth as a supportive therapy measure and in the prevention of recurrent bladder infections. (vagiflor.com)

D-Mannose is a type of sugar that occurs naturally in some plants in starch and is mainly found in cranberries. (hrsupplements.com)

As a member of the Sprout Supplements family, you can trust that D-Mannose with Cranberry is made with high-quality ingredients. (sproutsupps.com)

The natural D-Mannose sugar provides effective and lasting relief from acute symptoms such as a burning sensation when passing urine and the more frequent urge to urinate, without attacking the mucosa. (vagiflor.com)

however, many affected individuals have no signs or symptoms related to low mannose-binding lectin levels. (medlineplus.gov)

Sorry, 'D-Mannose Special' has been discontinued and is no longer available. (baar.com)

It galactose, Dcarabinose, Dcxylose and Dc should be made clear to the public that swalc mannose. (who.int)

While there are several treatment options to clear up your kidneys, nothing matches the potency of our organically produced D-Mannose. (viva-nutra.com)

β-Mannosidase is a lysosomal enzyme from the glycosyl hydrolase family 2 that cleaves the single β(1-4)-linked mannose at the nonreducing end of N-glycosylated proteins, and plays an important role in the polysaccharide degradation pathway. (rcsb.org)
The role of mannose-binding lectin in pneumococcal infection. (cdc.gov)

D-Mannose has a unique cell structure that allows it to adhere to undesirable foreign substances, which prevents them from sticking to the bladder's lining. (hrsupplements.com)

With decreased levels of mannose-binding lectin, the body does not recognize and fight foreign invaders efficiently. (medlineplus.gov)

Dissolve one effervescent tablet containing 2g of D-Mannose in 200 mL of water and drink immediately. (vagiflor.com)

Dolichol-phosphate-mannose synthase catalyzes the formation of Dolichol-phosphate-mannose from Dolichol-phosphate and GDP-mannose. (eurekamag.com)
One unit is defined as the amount of enzyme that catalyzes the formation of 1 μmol of GDP-Man from Mannose-1-P and GTP per minute at 37°C. (chemilyglycoscience.com)

Anatomy12

Organisms3

Diseases3

Chemicals and Drugs81

Analytical, Diagnostic and Therapeutic Techniques and Equipment8

Phenomena and Processes16

Information Science3

Participation of a trisaccharide-lipid in glycosylation of oviduct membrane glycoproteins. (1/2363)

Mannose inhibits Arabidopsis germination via a hexokinase-mediated step. (2/2363)

Glycosylation of asparagine-28 of recombinant staphylokinase with high-mannose-type oligosaccharides results in a protein with highly attenuated plasminogen activator activity. (3/2363)

Genetic evidence for the role of GDP-mannose in plant ascorbic acid (vitamin C) biosynthesis. (4/2363)

Alteration of mannose transport in fibroblasts from type I carbohydrate deficient glycoprotein syndrome patients. (5/2363)

Sugars and sugar derivatives which inhibit the short-circuit current of the everted small intestine of the rat. (6/2363)

Transmembrane folding of the human erythrocyte anion exchanger (AE1, Band 3) determined by scanning and insertional N-glycosylation mutagenesis. (7/2363)

Recombinant human interleukin-12 is the second example of a C-mannosylated protein. (8/2363)

Mannose

Mannose-Binding Lectins

Receptor, IGF Type 2

Mannosephosphates

Guanosine Diphosphate Mannose

Dolichol Monophosphate Mannose

Oligosaccharides

Mannosyltransferases

Mannose-6-Phosphate Isomerase

Lectins, C-Type

Mannans

Carbohydrates

Hexosephosphates

Mannosidases

Polyisoprenyl Phosphate Sugars

Receptors, Cell Surface

Mannosides

Carbohydrate Sequence

Monosaccharides

Polysaccharides

Glycoproteins

Glycosylation

alpha-Mannosidase

Polyisoprenyl Phosphate Monosaccharides

Glucosamine

Galactose

Carbohydrate Conformation

Glycopeptides

Lectins

Lysosomes

Fucose

Dolichol Phosphates

Methylmannosides

Hexoses

Acetylglucosamine

Molecular Sequence Data

Phosphotransferases (Phosphomutases)

Cathepsin D

Carbohydrate Metabolism

Mannose-Binding Lectin

Polyisoprenyl Phosphate Oligosaccharides

Hexosaminidases

Glycoside Hydrolases

beta-Mannosidase

Swainsonine

Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase

Endocytosis

Glucuronidase

Nucleoside Diphosphate Sugars

Plant Lectins

Glycolipids

Dolichol

Kinetics

Phosphoenolpyruvate Sugar Phosphotransferase System

Golgi Apparatus

Collectins

Amino Acid Sequence

Tunicamycin

Congenital Disorders of Glycosylation

Molecular Weight

Imino Furanoses

1-Deoxynojirimycin

Glucose

Chromatography, Paper

Mucolipidoses

Chromatography, Affinity

Cell Line

Indolizines

Insulin-Like Growth Factor II

Macrophages

Chromatography, Gel

Asparagine

Glycosylphosphatidylinositols

Acetylglucosaminidase

Electrophoresis, Polyacrylamide Gel

Biological Transport

Hexosamines

Cricetinae

Carbohydrate Metabolism, Inborn Errors

Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase