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MannoseMannose-Binding LectinsReceptor, IGF Type 2MannosephosphatesGuanosine Diphosphate MannoseDolichol Monophosphate MannoseOligosaccharidesMannosyltransferasesMannose-6-Phosphate IsomeraseLectins, C-TypeMannansCarbohydratesHexosephosphatesMannosidasesPolyisoprenyl Phosphate SugarsReceptors, Cell SurfaceMannosidesCarbohydrate SequenceMonosaccharidesPolysaccharidesGlycoproteinsGlycosylationalpha-MannosidasePolyisoprenyl Phosphate MonosaccharidesGlucosamineGalactoseCarbohydrate ConformationGlycopeptidesLectinsLysosomesFucoseDolichol PhosphatesMethylmannosidesHexosesAcetylglucosamineMolecular Sequence DataPhosphotransferases (Phosphomutases)Cathepsin DCarbohydrate MetabolismMannose-Binding LectinPolyisoprenyl Phosphate OligosaccharidesHexosaminidasesGlycoside Hydrolasesbeta-MannosidaseSwainsonineMannosyl-Glycoprotein Endo-beta-N-AcetylglucosaminidaseEndocytosisGlucuronidaseNucleoside Diphosphate SugarsPlant LectinsGlycolipidsDolicholKineticsPhosphoenolpyruvate Sugar Phosphotransferase SystemGolgi ApparatusCollectinsAmino Acid SequenceTunicamycinCongenital Disorders of GlycosylationMolecular WeightImino Furanoses1-DeoxynojirimycinGlucoseChromatography, PaperMucolipidosesChromatography, AffinityCell LineIndolizinesInsulin-Like Growth Factor IIMacrophagesChromatography, GelAsparagineGlycosylphosphatidylinositolsAcetylglucosaminidaseElectrophoresis, Polyacrylamide GelBiological TransportHexosaminesCricetinaeCarbohydrate Metabolism, Inborn ErrorsPeptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidasebeta-N-AcetylhexosaminidasesAcetylgalactosaminealpha-GlucosidasesEndosomesChromatography, Thin LayerProtein Processing, Post-TranslationalCell MembraneFructoseFlocculationTransferases (Other Substituted Phosphate Groups)GalanthusAmino AcidsFructokinasesLiverCarrier ProteinsCell Walltrans-Golgi NetworkCells, CulturedLigandsGuanosine Diphosphate SugarsProtein BindingMembrane GlycoproteinsUridine Diphosphate N-AcetylglucosamineRhamnoseEndoplasmic ReticulumMutationCationsRecombinant ProteinsXyloseConcanavalin ASugar AlcoholsDeoxy SugarsFibroblastsBinding SitesSubstrate SpecificityCattlePolyisoprenyl PhosphatesMagnetic Resonance SpectroscopyReceptors, MitogenReceptors, ImmunologicChromatography, Ion ExchangePinocytosisGlycoconjugates
Mannose: A hexose or fermentable monosaccharide and isomer of glucose from manna, the ash Fraxinus ornus and related plants. (From Grant & Hackh's Chemical Dictionary, 5th ed & Random House Unabridged Dictionary, 2d ed)Mannose-Binding Lectins: A subclass of lectins that are specific for CARBOHYDRATES that contain MANNOSE.Receptor, IGF Type 2: A receptor that is specific for IGF-II and mannose-6-phosphate. The receptor is a 250-kDa single chain polypeptide which is unrelated in structure to the type 1 IGF receptor (RECEPTOR, IGF TYPE 1) and does not have a tyrosine kinase domain.Mannosephosphates: Phosphoric acid esters of mannose.Guanosine Diphosphate Mannose: A nucleoside diphosphate sugar which can be converted to the deoxy sugar GDPfucose, which provides fucose for lipopolysaccharides of bacterial cell walls. Also acts as mannose donor for glycolipid synthesis.Dolichol Monophosphate Mannose: A lipophilic glycosyl carrier of the monosaccharide mannose in the biosynthesis of oligosaccharide phospholipids and glycoproteins.Oligosaccharides: Carbohydrates consisting of between two (DISACCHARIDES) and ten MONOSACCHARIDES connected by either an alpha- or beta-glycosidic link. They are found throughout nature in both the free and bound form.Mannosyltransferases: Enzymes that catalyze the transfer of mannose from a nucleoside diphosphate mannose to an acceptor molecule which is frequently another carbohydrate. The group includes EC 2.4.1.32, EC 2.4.1.48, EC 2.4.1.54, and EC 2.4.1.57.Mannose-6-Phosphate Isomerase: An enzyme that catalyzes the reversible isomerization of D-mannose-6-phosphate to form D-fructose-6-phosphate, an important step in glycolysis. EC 5.3.1.8.Lectins, C-Type: A class of animal lectins that bind to carbohydrate in a calcium-dependent manner. They share a common carbohydrate-binding domain that is structurally distinct from other classes of lectins.Mannans: Polysaccharides consisting of mannose units.Carbohydrates: The largest class of organic compounds, including STARCH; GLYCOGEN; CELLULOSE; POLYSACCHARIDES; and simple MONOSACCHARIDES. Carbohydrates are composed of carbon, hydrogen, and oxygen in a ratio of Cn(H2O)n.HexosephosphatesMannosidases: Glycoside hydrolases that catalyze the hydrolysis of alpha or beta linked MANNOSE.Polyisoprenyl Phosphate Sugars: Compounds functioning as activated glycosyl carriers in the biosynthesis of glycoproteins and glycophospholipids. They include the polyisoprenyl pyrophosphates.Receptors, Cell Surface: Cell surface proteins that bind signalling molecules external to the cell with high affinity and convert this extracellular event into one or more intracellular signals that alter the behavior of the target cell (From Alberts, Molecular Biology of the Cell, 2nd ed, pp693-5). Cell surface receptors, unlike enzymes, do not chemically alter their ligands.Mannosides: Glycosides formed by the reaction of the hydroxyl group on the anomeric carbon atom of mannose with an alcohol to form an acetal. They include both alpha- and beta-mannosides.Carbohydrate Sequence: The sequence of carbohydrates within POLYSACCHARIDES; GLYCOPROTEINS; and GLYCOLIPIDS.Monosaccharides: Simple sugars, carbohydrates which cannot be decomposed by hydrolysis. They are colorless crystalline substances with a sweet taste and have the same general formula CnH2nOn. (From Dorland, 28th ed)PolysaccharidesGlycoproteins: Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.Glycosylation: The chemical or biochemical addition of carbohydrate or glycosyl groups to other chemicals, especially peptides or proteins. Glycosyl transferases are used in this biochemical reaction.alpha-Mannosidase: An enzyme that catalyzes the HYDROLYSIS of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. The enzyme plays a role in the processing of newly formed N-glycans and in degradation of mature GLYCOPROTEINS. There are multiple isoforms of alpha-mannosidase, each having its own specific cellular location and pH optimum. Defects in the lysosomal form of the enzyme results in a buildup of mannoside intermediate metabolites and the disease ALPHA-MANNOSIDOSIS.Polyisoprenyl Phosphate Monosaccharides: These compounds function as activated monosaccharide carriers in the biosynthesis of glycoproteins and oligosaccharide phospholipids. Obtained from a nucleoside diphosphate sugar and a polyisoprenyl phosphate.GlucosamineGalactose: An aldohexose that occurs naturally in the D-form in lactose, cerebrosides, gangliosides, and mucoproteins. Deficiency of galactosyl-1-phosphate uridyltransferase (GALACTOSE-1-PHOSPHATE URIDYL-TRANSFERASE DEFICIENCY DISEASE) causes an error in galactose metabolism called GALACTOSEMIA, resulting in elevations of galactose in the blood.Carbohydrate Conformation: The characteristic 3-dimensional shape of a carbohydrate.Glycopeptides: Proteins which contain carbohydrate groups attached covalently to the polypeptide chain. The protein moiety is the predominant group with the carbohydrate making up only a small percentage of the total weight.Lectins: Proteins that share the common characteristic of binding to carbohydrates. Some ANTIBODIES and carbohydrate-metabolizing proteins (ENZYMES) also bind to carbohydrates, however they are not considered lectins. PLANT LECTINS are carbohydrate-binding proteins that have been primarily identified by their hemagglutinating activity (HEMAGGLUTININS). However, a variety of lectins occur in animal species where they serve diverse array of functions through specific carbohydrate recognition.Lysosomes: A class of morphologically heterogeneous cytoplasmic particles in animal and plant tissues characterized by their content of hydrolytic enzymes and the structure-linked latency of these enzymes. The intracellular functions of lysosomes depend on their lytic potential. The single unit membrane of the lysosome acts as a barrier between the enzymes enclosed in the lysosome and the external substrate. The activity of the enzymes contained in lysosomes is limited or nil unless the vesicle in which they are enclosed is ruptured. Such rupture is supposed to be under metabolic (hormonal) control. (From Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)FucoseDolichol Phosphates: Phosphoric acid esters of dolichol.Methylmannosides: Mannosides formed by the reaction of the hydroxyl group on the anomeric carbon atom of mannose with methyl alcohol. They include both alpha- and beta-methylmannosides.HexosesAcetylglucosamine: The N-acetyl derivative of glucosamine.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Phosphotransferases (Phosphomutases): A group of enzymes that catalyze an intramolecular transfer of a phosphate group. It has been shown in some cases that the enzyme has a functional phosphate group, which can act as the donor. These were previously listed under PHOSPHOTRANSFERASES (EC 2.7.-). (From Enzyme Nomenclature, 1992) EC 5.4.2.Cathepsin D: An intracellular proteinase found in a variety of tissue. It has specificity similar to but narrower than that of pepsin A. The enzyme is involved in catabolism of cartilage and connective tissue. EC 3.4.23.5. (Formerly EC 3.4.4.23).Carbohydrate Metabolism: Cellular processes in biosynthesis (anabolism) and degradation (catabolism) of CARBOHYDRATES.Mannose-Binding Lectin: A specific mannose-binding member of the collectin family of lectins. It binds to carbohydrate groups on invading pathogens and plays a key role in the MANNOSE-BINDING LECTIN COMPLEMENT PATHWAY.Polyisoprenyl Phosphate Oligosaccharides: These compounds function as activated glycosyl carriers in the biosynthesis of glycoproteins and glycophospholipids. Include the pyrophosphates.Hexosaminidases: Enzymes that catalyze the hydrolysis of N-acylhexosamine residues in N-acylhexosamides. Hexosaminidases also act on GLUCOSIDES; GALACTOSIDES; and several OLIGOSACCHARIDES.Glycoside Hydrolasesbeta-Mannosidase: An enzyme that catalyzes the hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides. The enzyme plays a role in the lysosomal degradation of the N-glycosylprotein glycans. Defects in the lysosomal form of the enzyme in humans result in a buildup of mannoside intermediate metabolites and the disease BETA-MANNOSIDOSIS.Swainsonine: An indolizidine alkaloid from the plant Swainsona canescens that is a potent alpha-mannosidase inhibitor. Swainsonine also exhibits antimetastatic, antiproliferative, and immunomodulatory activity.Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase: A group of related enzymes responsible for the endohydrolysis of the di-N-acetylchitobiosyl unit in high-mannose-content glycopeptides and GLYCOPROTEINS.Endocytosis: Cellular uptake of extracellular materials within membrane-limited vacuoles or microvesicles. ENDOSOMES play a central role in endocytosis.GlucuronidaseNucleoside Diphosphate SugarsPlant Lectins: Protein or glycoprotein substances of plant origin that bind to sugar moieties in cell walls or membranes. Some carbohydrate-metabolizing proteins (ENZYMES) from PLANTS also bind to carbohydrates, however they are not considered lectins. Many plant lectins change the physiology of the membrane of BLOOD CELLS to cause agglutination, mitosis, or other biochemical changes. They may play a role in plant defense mechanisms.Glycolipids: Any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic moiety such as an acylglycerol (see GLYCERIDES), a sphingoid, a ceramide (CERAMIDES) (N-acylsphingoid) or a prenyl phosphate. (From IUPAC's webpage)Dolichol: Eicosamethyl octacontanonadecasen-1-o1. Polyprenol found in animal tissues that contains about 20 isoprene residues, the one carrying the alcohol group being saturated.Kinetics: The rate dynamics in chemical or physical systems.Phosphoenolpyruvate Sugar Phosphotransferase System: The bacterial sugar phosphotransferase system (PTS) that catalyzes the transfer of the phosphoryl group from phosphoenolpyruvate to its sugar substrates (the PTS sugars) concomitant with the translocation of these sugars across the bacterial membrane. The phosphorylation of a given sugar requires four proteins, two general proteins, Enzyme I and HPr and a pair of sugar-specific proteins designated as the Enzyme II complex. The PTS has also been implicated in the induction of synthesis of some catabolic enzyme systems required for the utilization of sugars that are not substrates of the PTS as well as the regulation of the activity of ADENYLYL CYCLASES. EC 2.7.1.-.Golgi Apparatus: A stack of flattened vesicles that functions in posttranslational processing and sorting of proteins, receiving them from the rough ENDOPLASMIC RETICULUM and directing them to secretory vesicles, LYSOSOMES, or the CELL MEMBRANE. The movement of proteins takes place by transfer vesicles that bud off from the rough endoplasmic reticulum or Golgi apparatus and fuse with the Golgi, lysosomes or cell membrane. (From Glick, Glossary of Biochemistry and Molecular Biology, 1990)Collectins: A class of C-type lectins that target the carbohydrate structures found on invading pathogens. Binding of collectins to microorganisms results in their agglutination and enhanced clearance. Collectins form trimers that may assemble into larger oligomers. Each collectin polypeptide chain consists of four regions: a relatively short N-terminal region, a collagen-like region, an alpha-helical coiled-coil region, and carbohydrate-binding region.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Tunicamycin: An N-acetylglycosamine containing antiviral antibiotic obtained from Streptomyces lysosuperificus. It is also active against some bacteria and fungi, because it inhibits the glucosylation of proteins. Tunicamycin is used as tool in the study of microbial biosynthetic mechanisms.Congenital Disorders of Glycosylation: A genetically heterogeneous group of heritable disorders resulting from defects in protein N-glycosylation.Molecular Weight: The sum of the weight of all the atoms in a molecule.Imino Furanoses: Five-carbon furanose sugars in which the OXYGEN is replaced by a NITROGEN atom.1-Deoxynojirimycin: An alpha-glucosidase inhibitor with antiviral action. Derivatives of deoxynojirimycin may have anti-HIV activity.Glucose: A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.Chromatography, Paper: An analytical technique for resolution of a chemical mixture into its component compounds. Compounds are separated on an adsorbent paper (stationary phase) by their varied degree of solubility/mobility in the eluting solvent (mobile phase).Mucolipidoses: A group of inherited metabolic diseases characterized by the accumulation of excessive amounts of acid mucopolysaccharides, sphingolipids, and/or glycolipids in visceral and mesenchymal cells. Abnormal amounts of sphingolipids or glycolipids are present in neural tissue. INTELLECTUAL DISABILITY and skeletal changes, most notably dysostosis multiplex, occur frequently. (From Joynt, Clinical Neurology, 1992, Ch56, pp36-7)Chromatography, Affinity: A chromatographic technique that utilizes the ability of biological molecules to bind to certain ligands specifically and reversibly. It is used in protein biochemistry. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Cell Line: Established cell cultures that have the potential to propagate indefinitely.IndolizinesInsulin-Like Growth Factor II: A well-characterized neutral peptide believed to be secreted by the LIVER and to circulate in the BLOOD. It has growth-regulating, insulin-like and mitogenic activities. The growth factor has a major, but not absolute, dependence on SOMATOTROPIN. It is believed to be a major fetal growth factor in contrast to INSULIN-LIKE GROWTH FACTOR I, which is a major growth factor in adults.Macrophages: The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)Chromatography, Gel: Chromatography on non-ionic gels without regard to the mechanism of solute discrimination.Asparagine: A non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue. It is biosynthesized from ASPARTIC ACID and AMMONIA by asparagine synthetase. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)Glycosylphosphatidylinositols: Compounds containing carbohydrate or glycosyl groups linked to phosphatidylinositols. They anchor GPI-LINKED PROTEINS or polysaccharides to cell membranes.Acetylglucosaminidase: A beta-N-Acetylhexosaminidase that catalyzes the hydrolysis of terminal, non-reducing 2-acetamido-2-deoxy-beta-glucose residues in chitobiose and higher analogs as well as in glycoproteins. Has been used widely in structural studies on bacterial cell walls and in the study of diseases such as MUCOLIPIDOSIS and various inflammatory disorders of muscle and connective tissue.Electrophoresis, Polyacrylamide Gel: Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.Biological Transport: The movement of materials (including biochemical substances and drugs) through a biological system at the cellular level. The transport can be across cell membranes and epithelial layers. It also can occur within intracellular compartments and extracellular compartments.HexosaminesCricetinae: A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.Carbohydrate Metabolism, Inborn ErrorsPeptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase: An amidohydrolase that removes intact asparagine-linked oligosaccharide chains from glycoproteins. It requires the presence of more than two amino-acid residues in the substrate for activity. This enzyme was previously listed as EC 3.2.2.18.beta-N-Acetylhexosaminidases: A hexosaminidase specific for non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. It acts on GLUCOSIDES; GALACTOSIDES; and several OLIGOSACCHARIDES. Two specific mammalian isoenzymes of beta-N-acetylhexoaminidase are referred to as HEXOSAMINIDASE A and HEXOSAMINIDASE B. Deficiency of the type A isoenzyme causes TAY-SACHS DISEASE, while deficiency of both A and B isozymes causes SANDHOFF DISEASE. The enzyme has also been used as a tumor marker to distinguish between malignant and benign disease.Acetylgalactosamine: The N-acetyl derivative of galactosamine.alpha-Glucosidases: Enzymes that catalyze the exohydrolysis of 1,4-alpha-glucosidic linkages with release of alpha-glucose. Deficiency of alpha-1,4-glucosidase may cause GLYCOGEN STORAGE DISEASE TYPE II.Endosomes: Cytoplasmic vesicles formed when COATED VESICLES shed their CLATHRIN coat. Endosomes internalize macromolecules bound by receptors on the cell surface.Chromatography, Thin Layer: Chromatography on thin layers of adsorbents rather than in columns. The adsorbent can be alumina, silica gel, silicates, charcoals, or cellulose. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Protein Processing, Post-Translational: Any of various enzymatically catalyzed post-translational modifications of PEPTIDES or PROTEINS in the cell of origin. These modifications include carboxylation; HYDROXYLATION; ACETYLATION; PHOSPHORYLATION; METHYLATION; GLYCOSYLATION; ubiquitination; oxidation; proteolysis; and crosslinking and result in changes in molecular weight and electrophoretic motility.Cell Membrane: The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.Fructose: A monosaccharide in sweet fruits and honey that is soluble in water, alcohol, or ether. It is used as a preservative and an intravenous infusion in parenteral feeding.Flocculation: The aggregation of suspended solids into larger clumps.Transferases (Other Substituted Phosphate Groups): A class of enzymes that transfers substituted phosphate groups. EC 2.7.8.Galanthus: A plant genus in the family LILIACEAE (sometimes classified as Amaryllidaceae). Galanthus nivalis L. is the source of GALANTHAMINE.Amino Acids: Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.Fructokinases: A class of enzymes that catalyzes the phosphorylation of fructose in the presence of ATP. EC 2.7.1.-.Liver: A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.Carrier Proteins: Transport proteins that carry specific substances in the blood or across cell membranes.Cell Wall: The outermost layer of a cell in most PLANTS; BACTERIA; FUNGI; and ALGAE. The cell wall is usually a rigid structure that lies external to the CELL MEMBRANE, and provides a protective barrier against physical or chemical agents.trans-Golgi Network: A network of membrane compartments, located at the cytoplasmic side of the GOLGI APPARATUS, where proteins and lipids are sorted for transport to various locations in the cell or cell membrane.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Ligands: A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)Guanosine Diphosphate Sugars: Esters formed between the aldehydic carbon of sugars and the terminal phosphate of guanosine diphosphate.Protein Binding: The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.Membrane Glycoproteins: Glycoproteins found on the membrane or surface of cells.Uridine Diphosphate N-Acetylglucosamine: Serves as the biological precursor of insect chitin, of muramic acid in bacterial cell walls, and of sialic acids in mammalian glycoproteins.Rhamnose: A methylpentose whose L- isomer is found naturally in many plant glycosides and some gram-negative bacterial lipopolysaccharides.Endoplasmic Reticulum: A system of cisternae in the CYTOPLASM of many cells. In places the endoplasmic reticulum is continuous with the plasma membrane (CELL MEMBRANE) or outer membrane of the nuclear envelope. If the outer surfaces of the endoplasmic reticulum membranes are coated with ribosomes, the endoplasmic reticulum is said to be rough-surfaced (ENDOPLASMIC RETICULUM, ROUGH); otherwise it is said to be smooth-surfaced (ENDOPLASMIC RETICULUM, SMOOTH). (King & Stansfield, A Dictionary of Genetics, 4th ed)Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Cations: Positively charged atoms, radicals or groups of atoms which travel to the cathode or negative pole during electrolysis.Recombinant Proteins: Proteins prepared by recombinant DNA technology.XyloseConcanavalin A: A MANNOSE/GLUCOSE binding lectin isolated from the jack bean (Canavalia ensiformis). It is a potent mitogen used to stimulate cell proliferation in lymphocytes, primarily T-lymphocyte, cultures.Sugar Alcohols: Polyhydric alcohols having no more than one hydroxy group attached to each carbon atom. They are formed by the reduction of the carbonyl group of a sugar to a hydroxyl group.(From Dorland, 28th ed)Deoxy SugarsFibroblasts: Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.Binding Sites: The parts of a macromolecule that directly participate in its specific combination with another molecule.Substrate Specificity: A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.Cattle: Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.Polyisoprenyl Phosphates: Phosphoric or pyrophosphoric acid esters of polyisoprenoids.Magnetic Resonance Spectroscopy: Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).Receptors, Mitogen: Glycoprotein molecules on the surface of B- and T-lymphocytes, that react with molecules of antilymphocyte sera, lectins, and other agents which induce blast transformation of lymphocytes.Receptors, Immunologic: Cell surface molecules on cells of the immune system that specifically bind surface molecules or messenger molecules and trigger changes in the behavior of cells. Although these receptors were first identified in the immune system, many have important functions elsewhere.Chromatography, Ion Exchange: Separation technique in which the stationary phase consists of ion exchange resins. The resins contain loosely held small ions that easily exchange places with other small ions of like charge present in solutions washed over the resins.Pinocytosis: The engulfing of liquids by cells by a process of invagination and closure of the cell membrane to form fluid-filled vacuoles.Glycoconjugates: Carbohydrates covalently linked to a nonsugar moiety (lipids or proteins). The major glycoconjugates are glycoproteins, glycopeptides, peptidoglycans, glycolipids, and lipopolysaccharides. (From Biochemical Nomenclature and Related Documents, 2d ed; From Principles of Biochemistry, 2d ed)

Participation of a trisaccharide-lipid in glycosylation of oviduct membrane glycoproteins. (1/2363)

Preincubation of a hen oviduct membrane preparation with UDP-Nactyl[14C]glucosamine and bacitracin, followed by incubation with GDP-mannose, leads to formation of a chloroform/methanol (2/1)-extractable glycolipid. Treatment of the lipid with mild acid results in the release of a trisaccharide shown to have the structure beta-mannosyl-N-acetylglucosamineyl-N-acetylglucosamine. Incubation of purified trisaccharide-lipid with oviduct membranes in the presence of sodium deoxycholate, Mn2+, and GDP-mannose leads to formation of a labeled glycoprotein with an apparent molecular weight of 25,000...  (+info)

Mannose inhibits Arabidopsis germination via a hexokinase-mediated step. (2/2363)

Low concentrations of the glucose (Glc) analog mannose (Man) inhibit germination of Arabidopsis seeds. Man is phosphorylated by hexokinase (HXK), but the absence of germination was not due to ATP or phosphate depletion. The addition of metabolizable sugars reversed the Man-mediated inhibition of germination. Carbohydrate-mediated regulation of gene expression involving a HXK-mediated pathway is known to be activated by Glc, Man, and other monosaccharides. Therefore, we investigated whether Man blocks germination through this system. By testing other Glc analogs, we found that 2-deoxyglucose, which, like Man, is phosphorylated by HXK, also blocked germination; no inhibition was observed with 6-deoxyglucose or 3-O-methylglucose, which are not substrates for HXK. Since these latter two sugars are taken up at a rate similar to that of Man, uptake is unlikely to be involved in the inhibition of germination. Furthermore, we show that mannoheptulose, a specific HXK inhibitor, restores germination of seeds grown in the presence of Man. We conclude that HXK is involved in the Man-mediated repression of germination of Arabidopsis seeds, possibly via energy depletion.  (+info)

Glycosylation of asparagine-28 of recombinant staphylokinase with high-mannose-type oligosaccharides results in a protein with highly attenuated plasminogen activator activity. (3/2363)

The properties of recombinant staphylokinase (SakSTAR) expressed in Pichia pastoris cells have been determined. The single consensus N-linked oligosaccharide linkage site in SakSTAR (at Asn28 of the mature protein) was occupied in approximately 50% of the expressed protein with high-mannose-type oligosaccharides. The majority of these glycans ranged in polymerization state from Man8GlcNAc2 to Man14GlcNAc2, with the predominant species being Man10GlcNAc2 and Man11GlcNAc2. Glycosylated SakSTAR (SakSTARg) did not differ from its aglycosyl form in its aggregation state in solution, its thermal denaturation properties, its ability to form a complex with human plasmin (hPm), the amidolytic properties of the respective SakSTAR-hPm complexes, or its ability to liberate the amino-terminal decapeptide required for formation of a functional SakSTAR-hPm plasminogen activator complex. However, this latter complex with SakSTARg showed a greatly reduced ability to activate human plasminogen (hPg) as compared with the same complex with the aglycosyl form of SakSTAR. We conclude that glycosylation at Asn28 does not affect the structural properties of SakSTAR or its ability to participate in the formation of an active enzymatic complex with hPm, but it is detrimental to the ability of the SakSTAR-hPm complex to serve as a hPg activator. This is likely due to restricted access of hPg to the active site of the SakSTARg-hPm complex.  (+info)

Genetic evidence for the role of GDP-mannose in plant ascorbic acid (vitamin C) biosynthesis. (4/2363)

Vitamin C (L-ascorbic acid; AsA) acts as a potent antioxidant and cellular reductant in plants and animals. AsA has long been known to have many critical physiological roles in plants, yet its biosynthesis is only currently being defined. A pathway for AsA biosynthesis that features GDP-mannose and L-galactose has recently been proposed for plants. We have isolated a collection of AsA-deficient mutants of Arabidopsis thaliana that are valuable tools for testing of an AsA biosynthetic pathway. The best-characterized of these mutants (vtc1) contains approximately 25% of wild-type AsA and is defective in AsA biosynthesis. By using a combination of biochemical, molecular, and genetic techniques, we have demonstrated that the VTC1 locus encodes a GDP-mannose pyrophosphorylase (mannose-1-P guanyltransferase). This enzyme provides GDP-mannose, which is used for cell wall carbohydrate biosynthesis and protein glycosylation as well as for AsA biosynthesis. In addition to genetically defining the first locus involved in AsA biosynthesis, this work highlights the power of using traditional mutagenesis techniques coupled with the Arabidopsis Genome Initiative to rapidly clone physiologically important genes.  (+info)

Alteration of mannose transport in fibroblasts from type I carbohydrate deficient glycoprotein syndrome patients. (5/2363)

The aim of the present study was to explore how mannose enters fibroblasts derived from a panel of children suffering from different subtypes of type I carbohydrate deficient glycoprotein syndrome: seven carbohydrate deficient glycoprotein syndrome subtype Ia (phosphomannomutase deficiency), two carbohydrate deficient glycoprotein syndrome subtype Ib (phosphomannose isomerase deficiency) and two carbohydrate deficient glycoprotein syndrome subtype Ix (not identified deficiency). We showed that a specific mannose transport system exists in all the cells tested but has different characteristics with respect to carbohydrate deficient glycoprotein syndrome subtypes. Subtype Ia fibroblasts presented a mannose uptake equivalent or higher (maximum 1.6-fold) than control cells with a D-[2-3H]-mannose incorporation in nascent N-glycoproteins decreased up to 7-fold. Compared to control cells, the mannose uptake was greatly stimulated in subtype Ib (4.0-fold), due to lower Kuptake and higher Vmax values. Subtype Ib cells showed an increased incorporation of D-[2-3H]-mannose into nascent N-glycoproteins. Subtype Ix fibroblasts presented an intermediary status with mannose uptake equivalent to the control but with an increased incorporation of D-[2-3H]-mannose in nascent N-glycoproteins. All together, our results demonstrate quantitative and/or qualitative modifications in mannose transport of all carbohydrate deficient glycoprotein syndrome fibroblasts in comparison to control cells, with a relative homogeneity within a considered subtype of carbohydrate deficient glycoprotein syndrome. These results are consistent with the possible use of mannose as a therapeutic agent in carbohydrate deficient glycoprotein syndrome Ib and Ix.  (+info)

Sugars and sugar derivatives which inhibit the short-circuit current of the everted small intestine of the rat. (6/2363)

1. The short-circuit current of everted rat intestine supported on a perforated cannula proved to be stable for up to 3 hr and has been used to study competition between transportable and non-transportable sugars. 2. 4,6-O-Ethylidene-alpha-D-glucopyranose (ethylidene glucose) and 4,6-O-benzylidene-e alpha-D-glucopyranos (benzylinene glucose), two nontransportable inhibitors of the hexose transfer system in human erythrocytes, were found to reduce the short-circuit current generated by transportable sugars such as galactose or 3-O-methyl glucose. 3. These compounds were also found to reduce the basal short-circuit current established by the everted intestine in a sugar-free Krebs solution. Both types of inhibition approached saturation at the higher concentrations used. 4. Similar inhibitory properties were shown by mannose, a non-actively accumulated monosaccharide, and by the beta-disaccharides lactose and cellobiose. 5. It is suggested that this common pattern of behaviour is due to the ability of these compounds to react with the sites for active hexose transfer but without translocation by the system. The significance of the inhibition of the basal short-circuit current is briefly discussed in this context.  (+info)

Transmembrane folding of the human erythrocyte anion exchanger (AE1, Band 3) determined by scanning and insertional N-glycosylation mutagenesis. (7/2363)

The human erythrocyte anion exchanger (AE1, Band 3) contains up to 14 transmembrane segments, with a single site of N-glycosylation at Asn642 in extracellular (EC) loop 4. Scanning and insertional N-glycosylation mutagenesis were used to determine the folding pattern of AE1 in the membrane. Full-length AE1, when expressed in transfected human embryonic kidney (HEK)-293 or COS-7 cells, retained a high-mannose oligosaccharide structure. Scanning N-glycosylation mutagenesis of EC loop 4 showed that N-glycosylation acceptor sites (Asn-Xaa-Ser/Thr) spaced 12 residues from the ends of adjacent transmembrane segments could be N-glycosylated. An acceptor site introduced at position 743 in intracellular (IC) loop 5 that could be N-glycosylated in a cell-free translation system was not N-glycosylated in transfected cells. Mutations designed to disrupt the folding of this loop enhanced the level of N-glycosylation at Asn743 in vitro. The results suggest that this loop might be transiently exposed to the lumen of the endoplasmic reticulum during biosynthesis but normally folds rapidly, precluding N-glycosylation. EC loop 4 insertions into positions 428, 484, 754 and 854 in EC loops 1, 2, 6 and 7 respectively were efficiently N-glycosylated, showing that these regions were extracellular. EC loop 4 insertions into positions 731 or 785 were poorly N-glycosylated, which was inconsistent with an extracellular disposition for these regions of AE1. Insertion of EC loop 4 into positions 599 and 820 in IC loops 3 and 6 respectively were not N-glycosylated in cells, which was consistent with a cytosolic disposition for these loops. Inhibitor-affinity chromatography with 4-acetamido-4'-isothiocyanostilbene-2,2'-disulphonate (SITS)-Affi-Gel was used to assess whether the AE1 mutants were in a native state. Mutants with insertions at positions 428, 484, 599, 731 and 785 showed impaired inhibitor binding, whereas insertions at positions 754, 820 and 854 retained binding. The results indicate that the folding of the C-terminal region of AE1 is more complex than originally proposed and that this region of the transporter might have a dynamic aspect.  (+info)

Recombinant human interleukin-12 is the second example of a C-mannosylated protein. (8/2363)

The beta-chain of human interleukin 12 (IL-12) contains at position 319-322, the sequence Trp-x-x-Trp. In human RNase 2 this is the recognition motif for a new, recently discovered posttranslational modification, i.e., the C-glycosidic attachment of a mannosyl residue to the side chain of tryptophan. Analysis of C-terminal peptides of recombinant IL-12 (rHuIL-12) by mass spectrometry and NMR spectroscopy revealed that Trp-319beta is (partially) C-mannosylated. This finding was extended by in vitro mannosylation experiments, using a synthetic peptide derived from the same region of the protein as an acceptor. Furthermore, human B-lymphoblastoid cells, which secrete IL-12, were found to contain an enzyme that carries out the C-mannosylation reaction. This shows that nonrecombinant IL-12 is potentially C-mannosylated as well. This is only the second report on a C-mannosylated protein. However, the occurrence of the C-mannosyltransferase activity in a variety of cells and tissues, and the presence of the recognition motif in many proteins indicate that more C-mannosylated proteins may be found.  (+info)

Introduction to Xanthan - Structure | CyberColloidsIntroduction to Xanthan - Structure | CyberColloids
Xanthan has a particularly complicated molecular structure. however the backbone of xanthan is a β-(1-4)-D-glucose which is the same as cellulose. Every alternate glucose reside has a three sugar side chain consisting of two mannose residues with a glucuronic acid residue between them. The mannose reside nearest the main chain can carry a C6 acetyl group and the terminal mannose can carry a pyruvate group between C4 and C6. The acetylation and pyruvylation levels vary depending on fermentation conditions but typical values. Typically pyruvate residues can be found on 30-40% of the terminal mannose residues whereas 60-70% of the internal mannose residues may contain acetate groups. Recent work has looked at the properties of GM modified strains of xanthan gum that are either deficient in acetate groups, pyruvate groups or both. (Talashek).. Xanthan is produced in its native state as a twin stranded, right handed five fold helix. The stability of the helix is strongly affected by the ionic ...
Mannose shows antitumour properties against <b>lung</b> <b>cancer</b> via inhibiting proliferation, promoting cisplatin...Mannose shows antitumour properties against <b>lung</b> <b>cancer</b> via inhibiting proliferation, promoting cisplatin...
cell cycle distribution and cisplatin‑mediated apoptosis of NSCLC cells. Transwell migration and invasion assays were conducted to examine whether mannose could inhibit the invasive abilities of NSCLC cells. The effects of mannose on the PI3K/AKT and ERK signalling pathways were explored through western blot analysis assessing the expression of phosphorylated (p)‑AKT and p‑ERK1/2. It was found that mannose showed potential anticancer effects against NSCLC cells in vitro by inhibiting proliferation, inducing G0/G1 cell cycle arrest, promoting cisplatin‑induced apoptosis and decreasing the invasive abilities. These data indicate the potential anticancer properties of mannose and suggest the application of mannose‑based therapies to treat NSCLC. ...
Annual Review of Immunology Volume 25 2007 by Annual Reviews - Maraton Pide-karadeniz LibraryAnnual Review of Immunology Volume 25 2007 by Annual Reviews - Maraton Pide-karadeniz Library
Deglycosylated IgE is shown for comparison (bottom right). An IgE Fab is highlighted (top right), showing Asn-140 and Asn-218 occupied by oligosaccharides in a single orientation. However, in vivo, glycans are very flexible; therefore, the sugar at Asn-168 is represented by a series of plausible conformational overlays to indicate the large surface area of the protein that can be shielded. See Figure 1 for color code. Oligomannose glycans: N-linked glycans that contain from 5-9 mannose residues attached to the chitobiose core 28 and 12% oligomannose glycans. Chem. 277:29005-11 16. Mimura Y, Sondermann P, Ghirlando R, Lund J, Young SP, et al. 2001. Role of oligosaccharide residues of IgG1-Fc in FcγRIIb binding. J. Biol. Chem. 276:45539-47 17. Dong X, Storkus WJ, Salter RD. 1999. Binding and uptake of agalactosyl IgG by mannose receptor on macrophages and dendritic cells. J. Immunol. 163:5427-34 18. Sutton BJ, Phillips DC. 1983. The three-dimensional structure of the carbohydrate within the Fc ...
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D-Mannose Urinary Tract Cleanse 120 Capsules 500 mg D Mannose NOW Foods - Compare Price and Reviews at VitaDigest.comD-Mannose Urinary Tract Cleanse 120 Capsules 500 mg D Mannose NOW Foods - Compare Price and Reviews at VitaDigest.com
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Lipid Protein Interactions: The Assembly of CD1d1 with Cellular Phospholipids Occurs in the Endoplasmic Reticulum | The Journal...Lipid Protein Interactions: The Assembly of CD1d1 with Cellular Phospholipids Occurs in the Endoplasmic Reticulum | The Journal...
Mannose can randomize to glucose, galactose, and fucose. However, because the label in [3H]2-mannose is on the hydrogen of C-atom 2, the label would be predominantly found in mannose and fucose. In rare instances, the label from [3H]2-mannose can be found in glucose and lactic acid, suggesting that during oxidation and reduction reaction resulting in the epimerization of mannose to glucose, the label may be transferred from C-atom 2 to C-atom 1 (see Ref. 31). Thus, the major labeled spot in Fig. 1⇑ could be due to a glycan modifying a lipid and/or a protein. For three reasons we believe that the [3H]2-mannose-labeled compound is a glycolipid and not a glycopeptide or glycoprotein. First, the control Db-sol, also a glycoprotein with two N-linked glycans, processed in the same manner as sCD1d1, does not contain the tritiated spots seen with the CD1 sample (Fig. 1⇑). Second, the CD1d1-associated [3H]2-mannose-labeled ligands are PI-PLC sensitive as described below. Third, sialic acid-containing ...
Mannose | Grand Strand HealthMannose | Grand Strand Health
Learn more about Mannose at Grand Strand Medical Center Alternate Names d-Mannose Uses Principal Proposed Uses: Urinary Tract Infections ...
Mannose | Memorial HospitalMannose | Memorial Hospital
Learn more about Mannose at Memorial Hospital Alternate Names d-Mannose Uses Principal Proposed Uses: Urinary Tract Infections ...
Mannose | Portsmouth Regional HospitalMannose | Portsmouth Regional Hospital
Learn more about Mannose at Portsmouth Regional Hospital Alternate Names d-Mannose Uses Principal Proposed Uses: Urinary Tract Infections ...
iHerb CustomeriHerb Customer
I had a urinary infection and used the Mannose for one day thinking that was all I needed after reading info about the product. After that first day my symptoms were gone but I continued to take the Mannose the next day, but only a few teaspoons. My infection came back with a vengeance, I got a fever and it seemed that it was getting into my kidneys. I tried one antibiotic, cepro, took 2 pills and saw all the side effects and switched to another one. The next antibiodic didnt clear up the infection either although since I was taking one bottle a day of the Mannose and had no symptoms. As soon as I stopped the Mannose the symptoms returned. I went one more round with another antibiodic with no relief and stopped the Mannose so I could tell if the drugs were helping. They werent! Went to my naturopath and he recommended continuing with the mannose, the probiotics as well as his remedy which was to support the kidneys. I had also purchased the Jarrow Formulas, Fem-Dophilus, as I saw a series of ...
4-O-β-D-galactopyranosyl-D-[1-13C]mannose - Creative Proteomics4-O-β-D-galactopyranosyl-D-[1-13C]mannose - Creative Proteomics
Creative-Proteomics offer cas 50468-56-9 4-O-β-D-galactopyranosyl-D-[1-13C]mannose. We are specialized in manufacturing Stabel Isotope Labeled Analytical Standard products.
Profile | Biosciences | University of ExeterProfile | Biosciences | University of Exeter
The fungal cell wall is the first point of interaction between an invading fungal pathogen and the host immune system. The outer layer of the cell wall is comprised of GPI anchored proteins, which are post-translationally modified by both N- and O-linked glycans. These glycans are important pathogen associated molecular patterns (PAMPs) recognised by the innate immune system. Glycan synthesis is mediated by a series of glycosyl transferases, located in the endoplasmic reticulum and Golgi apparatus. Mnn2 is responsible for the addition of the initial α1,2-mannose residue onto the α1,6-mannose backbone, forming the N-mannan outer chain branches. In Candida albicans, the MNN2 gene family is comprised of six members (MNN2, MNN21, MNN22, MNN23, MNN24 and MNN26). Using a series of single, double, triple, quintuple and sextuple mutants, we show, for the first time, that addition of α1,2-mannose is required for stabilisation of the α1,6-mannose backbone and hence regulates mannan fibril length. ...
Manchester Area Cross Country LeagueManchester Area Cross Country League
1 David Norman Altrincham 13 ( 0, 4, 5, 2, 2) 2 Andrew Norman Altrincham 14 ( 6, 0, 4, 3, 1) 3 Patrick Gardiner E Cheshire 25 ( 9, 8, 0, 5, 3) 4 Paul Green V40 Sale H Man 38 ( 12, 0, 10, 9, 7) 5 Nigel Martin Sale H Man 47 ( 17, 17, 0, 8, 5) = David Marsh Sale H Man 47 ( 18, 41, 14, 7, 8) 7 Bruno Lima Salford H& 54 ( 19, 27, 12, 13, 10) 8 Ian Wetherall V45 Sale H Man 69 ( 23, 23, 0, 11, 12) 9 Alex Lawton Mchr tri 74 ( 15, 16, 33, 10, 0) 10 Peter Speake Wilmslow R 75 ( 25, 26, 17, 17, 16) 11 Colin Bannothornton V40 Altrincham 92 ( 0, 31, 16, 24, 21) 12 Tom Griffiths StHelSutt 111 ( 52, 24, 15, 20, 0) 13 David Alexander V45 West Chesh 121 ( 46, 36, 20, 38, 27) 14 Rob Downs V50 Wilmslow R 131 ( 30, 34, 0, 28, 39) 15 Phil Scowcroft Sale H Man 137 ( 58, 53, 30, 31, 23) 16 Richard McGeachie U20 Halton&fro 146 ( 0, 52, 29, 32, 33) 17 Barry Archbold V40 Wilmslow R 155 ( 47, 48, 36, 43, 29) 18 Paul Hawkins Wilmslow R 157 ( 0, 92, 23, 22, 20) 19 Aaron Schofield E Cheshire 161 ( 49, 45, 32, 0, 35) 20 ...
Recombinant Prokaryotic Lectin RPL with specificity for Terminal Mannose: RPL-Man2, L-007-2MG | AMSBIORecombinant Prokaryotic Lectin RPL with specificity for Terminal Mannose: RPL-Man2, L-007-2MG | AMSBIO
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how to get rid of a uti without antibioticshow to get rid of a uti without antibiotics
You may not have a choice about getting cystitis or UTIs, but you do have a choice in how you heal yourself and antibiotics for UTI are not the answer. There is a natural alternative that works every time, no matter how many times you use it and doesnt harm your body. It is called D Mannose.. D Mannose is a type of sugar extracted from birch trees; so safe that babies, and women during pregnancy can take it. The best thing is that it heals the infection within hours. If taken correctly THIS IS VITAL as Ive recommended to my friends, who had the same problem, to stop getting antibiotics for UTI before and they needed me to tell them how to take D Mannose properly before it worked for them.. Once you know how to take D Mannose effectively, its really easy and gentle and simple. I would absolutely, categorically never go back to antibiotics for UTI, this product is a lifesaver and you wont regret trying it. Just remember to read my article on how to take D Mannose so it works first time.. ...
antibiotics utiantibiotics uti
You may not have a choice about getting cystitis or UTIs, but you do have a choice in how you heal yourself and antibiotics for UTI are not the answer. There is a natural alternative that works every time, no matter how many times you use it and doesnt harm your body. It is called D Mannose.. D Mannose is a type of sugar extracted from birch trees; so safe that babies, and women during pregnancy can take it. The best thing is that it heals the infection within hours. If taken correctly THIS IS VITAL as Ive recommended to my friends, who had the same problem, to stop getting antibiotics for UTI before and they needed me to tell them how to take D Mannose properly before it worked for them.. Once you know how to take D Mannose effectively, its really easy and gentle and simple. I would absolutely, categorically never go back to antibiotics for UTI, this product is a lifesaver and you wont regret trying it. Just remember to read my article on how to take D Mannose so it works first time.. ...
Mannose - wikidocMannose - wikidoc
The fact that D-mannose has the same configuration at its penultimate carbon as D-glyceraldehyde is unsurprising as that is what defines the dextro classification. However, mannose differs from D-glucose by inversion of the C2 chiral centre. This apparently simple change leads to the drastically different chemistry of the two hexoses, as it does the remaining six hexoses. ...
Single-chain antibody-fragment M6P-1 possesses a mannose 6-phosphate monosaccharide-specific binding pocket that distinguishes...Single-chain antibody-fragment M6P-1 possesses a mannose 6-phosphate monosaccharide-specific binding pocket that distinguishes...
Blackler RJ, Evans DW, Smith DF, Cummings RD, Brooks CL, Braulke T, Liu X, Evans SV, Müller-Loennies S. Single-chain antibody-fragment M6P-1 possesses a mannose 6-phosphate monosaccharide-specific binding pocket that distinguishes N-glycan phosphorylation in a branch-specific manner†. Glycobiology. 2016;26 (2) :181-92.
D-[UL-2H7]mannose - Creative ProteomicsD-[UL-2H7]mannose - Creative Proteomics
Creative-Proteomics offer cas 3458-28-4 D-[UL-2H7]mannose. We are specialized in manufacturing Stabel Isotope Labeled Analytical Standard products.
Mannose impairs tumor growth and enhance chemotherapy<...Mannose impairs tumor growth and enhance chemotherapy<...
TY - JOUR. T1 - Mannose impairs tumor growth and enhance chemotherapy. AU - Nakajima, Kazuki. PY - 2019/1/1. Y1 - 2019/1/1. UR - http://www.scopus.com/inward/record.url?scp=85072119080&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=85072119080&partnerID=8YFLogxK. U2 - 10.4052/tigg.1963.6J. DO - 10.4052/tigg.1963.6J. M3 - Comment/debate. AN - SCOPUS:85072119080. VL - 31. SP - J87-J88. JO - Trends in Glycoscience and Glycotechnology. JF - Trends in Glycoscience and Glycotechnology. SN - 0915-7352. IS - 180. ER - ...
D Mannose Best Price in Canada | Compare & Buy with Shopbot.caD Mannose Best Price in Canada | Compare & Buy with Shopbot.ca
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Problems with D Mannose making me sick.. - Bladder Health UK ForumsProblems with D Mannose making me sick.. - Bladder Health UK Forums
I came on here and a lot of people recommended D Mannose. The reviews for it were so positive, however I started taking it 2 days ago and have been very very sick since then. I travel to work on a tram and I found myself being sick when I arrived at work. I do have travel sickness but this has been controllable for the last 8-10 years, and certainly it hasnt been that bad since I have been 8 years old ...
D-Mannose, Supplements categoryD-Mannose, Supplements category
D-mannose might treat the deficiency caused by a genetic defect that causes abnormal breakdown and production of mannose. D-mannose might prevent certain kinds of bacteria from sticking to the walls of the urinary tract and causing infection. - WebMD
Free E-Book on UTI-Slip D-Mannose Preview | Wellness PartnersFree E-Book on UTI-Slip D-Mannose Preview | Wellness Partners
|META NAME=DESCRIPTION CONTENT=Read on to learn more about UTI - Slip D- Mannose with this Free E-book, Just add this to your cart and you will receive a link at checkout! | |META NAME=ABSTRACT CONTENT= Free E-Book on UTI-Slip D-Mannose Preview | Wellness Partners | |META NAME=KEYWORDS CONTENT= Free E-Book on UTI-Slip D-Mannose Preview, Wellness Partners |
D-mannose - Purchase High Quality D-mannoseD-mannose - Purchase High Quality D-mannose
D-mannose.com provides customers a website from which to purchase or source the highest quality D-mannose in wholesale quantities.
D-Mannose With Cranactin - Solaray | SanavitaD-Mannose With Cranactin - Solaray | Sanavita
Mannose With Cranactin lupta natural impotriva infectiillor urinare. Cumpara acum Mannose With Cranactin la un pret special cu livrare rapida din stocul Sanavita
Rob The Plane, Le$, Cire, DMour, Change, Ely G, Roofie, Ovi, Snap Is Far Out - Above The Clouds Mixtape Mixtape - Stream &...Rob The Plane, Le$, Cire, D'Mour, Change, Ely G, Roofie, Ovi, Snap Is Far Out - Above The Clouds Mixtape Mixtape - Stream &...
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Ujv ry G bor: H man B lint rehabilit l saUjv ry G bor: H man B lint rehabilit l sa
A Rubicon t rt nelmi foly irat honlapja. A tartalma szerint tudom nyos ismeretterjeszt foly irat magazinszer en n pszer s ti a t rt nelmet. Ahogy az iskol ban nem hallhatta...
D-Mannose | Superior LabsD-Mannose | Superior Labs
D-Mannose, from Superior Labs, is one of our highly rated supplements and supports urinary tract health, liver function, and healthy intestine function. Free shipping on orders over $35.
D-MANNOSE WITH CRANACTIN - tratament infectii urinare - P.M. INNOVATION LABORATORIES SRLD-MANNOSE WITH CRANACTIN - tratament infectii urinare - P.M. INNOVATION LABORATORIES SRL
D-Mannose with Cranactin ajuta la reducerea simptomelor infectiilor urinare acute si cronice cu bacteria E.coli. Reduce placa bacteriana dentara
SOLARAY: Solaray D-Mannose w/CranActin - 1000 mg - 120 Veg CapSOLARAY: Solaray D-Mannose w/CranActin - 1000 mg - 120 Veg Cap
Solaray D-Mannose w/CranActin - 120 VCaps: Offering the entire line of Solaray and Nutraceutical vitamins, minerals, and supplements. Free shipping on orders over $100!
Identification of the methyl phosphate substituent at the non-reducing terminal mannose residue of the O-specific...Identification of the methyl phosphate substituent at the non-reducing terminal mannose residue of the O-specific...
Identification of the methyl phosphate substituent at the non-reducing terminal mannose residue of the O-specific polysaccharides of Klebsiella pneumoniae O3, Hafnia alvei PCM 1223 and Escherichia coli O9/O9a LPS
Targeting the Mannose Receptor with Mannosylated Subunit Vaccines | Bentham ScienceTargeting the Mannose Receptor with Mannosylated Subunit Vaccines | Bentham Science
Title:Targeting the Mannose Receptor with Mannosylated Subunit Vaccines. VOLUME: 21 ISSUE: 30. Author(s):B. Sedaghat, R. Stephenson and I. Toth. Affiliation:School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, QLD, Australia.. Keywords:Dendritic cells, glycosyl, mannan, mannose receptor, peptide vaccine, targeting.. Abstract:The mannose receptor (MR) is an important component of the immune system and understanding the structural and conformational characteristics of this receptor is a key aspect of vaccine design. Improved understanding of the role of carbohydrate recognition domains 4-7 (CRDs 4-7) in recognising glycosylated ligands present on the surface of pathogens such as C.albicans, P. carinii, L. donovani, and M. tuberculosis has given new insight into MR vaccine development. Initial studies identified mannan and its derivatives to be important ligands in MR targeting, providing essential knowledge about the MR structural properties. The MR was found to ...
Chromatography on mannose agarose indicating an in vivo interaction of both | emailexporter.comChromatography on mannose agarose indicating an in vivo interaction of both | emailexporter.com
Chromatography on mannose agarose indicating an in vivo interaction of both proteins. The same method applied to a lecBdeficient mutant of P. Eliglustat site
Mannose binding protein deficiency is not associated with malaria, hepatitis B carriage nor tuberculosis in Africans. - PubMed...Mannose binding protein deficiency is not associated with malaria, hepatitis B carriage nor tuberculosis in Africans. - PubMed...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Global D-(+)-Mannose Market 2019 Scenario of Top Sellers:Danisco(Dupont), Naturesupplies, Douglas Laboratories, Sweet Cures,...Global D-(+)-Mannose Market 2019 Scenario of Top Sellers:Danisco(Dupont), Naturesupplies, Douglas Laboratories, Sweet Cures,...
A comprehensive research study titled Global D-(+)-Mannose Market presented here is a smart interpretation on the global market which presents associate in-depth define of the D-(+)-Mannose market. The report contains insightful data on the main sectors of the global market. The report segments the market by its types, applications, players, and regions on the basis of its production, consumption, and revenue. The research covers detail information with reference to numerous shoppers thats that the foremost necessary part for the makers. The report encompasses the market summary, market dynamics, competitive analysis, and leading players numerous ways in which to sustain within the international market.. Get a Sample Copy at: https://www.mrinsights.biz/report-detail/203541/request-sample Introduction of Global D-(+)-Mannose Market:. The report then covers factors such as market share, CAGR, production, and consumption with respect to the geographical sectors. The report estimates the lookup of ...
MRC1 (Mannose receptor, C type 1) | Center for Academic Research and Training in Anthropogeny (CARTA)MRC1 (Mannose receptor, C type 1) | Center for Academic Research and Training in Anthropogeny (CARTA)
Mannose Receptor, C type 1 (MRC1) is a membrane receptor that mediates the endocytosis of glycoproteins by macrophages. MRC1 binds mannose structures on the surface of viruses, bacteria, and fungi to be neutralized by phagocytosis. Changes in MCR1 have been associated with multiple diseases including the development of leprosy, sarcoidosis, Alzheimers disease, and asthma. Human has more copies of MRC1 than any other primate which could have had important implications for the multiple diseases that MRC1 may be involved in.. ...
Cloning, sequence, expression and characterization of human β-mannosidase - Acta Biochimica Polonica - Volume 55, Issue 3 (2008...Cloning, sequence, expression and characterization of human β-mannosidase - Acta Biochimica Polonica - Volume 55, Issue 3 (2008...
β-mannosidase (EC 3.2.1.25, MANB) dissects the non-reducing end of N-linked mannose moieties of glycoproteins in eukaryotic cells. The human β-mannosidase gene was amplified by RT-PCR, cloned and sequenced. The DNA sequence was compared with reported human β-mannosidase DNA sequence and sixteen nucleotide differences were found. The deduced amino-acid sequence showed that seven codons coded the same amino acids and nine codons coded different amino acids with reference to nucleotide substitution positions but did not affect recombinant MANB enzyme activity. No splice mutation was observed after comparison with reported MANB DNA sequences. A 75% homology of deduced amino-acid sequence was observed with mouse, goat and bovine β-mannosidase amino-acid sequences. The cloned β-mannosidase gene was subcloned into pET22b+ and pET28a+ expression vectors to transform the BL21-codon plus cells for expression of recombinant MAN22 and MAN28 enzymes, respectively. The optimized conditions for ...
Solyc06g010060.1.1 protein (Solanum lycopersicum) - STRING network viewSolyc06g010060.1.1 protein (Solanum lycopersicum) - STRING network view
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit ; Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains (434 aa ...
Simple sugar supplement can slow cancer growth - Diabetrose - Waterfall D-Mannose - Fytoiasis - ΦυτοθεραπείαSimple sugar supplement 'can slow cancer growth - Diabetrose - Waterfall D-Mannose - Fytoiasis - Φυτοθεραπεία
The reason? The tumours, hungry for glucose, were being starved. Mannose seems to get in the way.. The experiments suggest that mannose does not so much block glucose getting to the cancer cells but rather affect how those cells try to use the glucose.. A key sign that it is working is the presence of an enzyme called phosphomannose isomerase (PMI). Mannose is linked to lower levels of PMI in cancer cells.. The Beatson Institute researchers tested this aspect on human cancer cells in the lab.. Ovarian, kidney, breast, prostate and bowel cancer cells were among those tested. The lowest PMI levels were found with bowel cancer cells. Mice with the same cancer also developed significantly fewer tumours.. There are, however, significant caveats. This is not a cancer cure. It may not even be a treatment.. To move from this discovery to something that can be given to patients may take years.. ...
702. Analysis of a Cell-Surface Receptor (EXP-702) | Modern Biology Inc. Creative Experiments used in teaching labs of College...702. Analysis of a Cell-Surface Receptor (EXP-702) | Modern Biology Inc. Creative Experiments used in teaching labs of College...
Chemical signaling between cells in multicellular organisms is frequently mediated by cell-surface receptors. The receptors for neurotransmitters, protein hormones, growth factors, and plant lectins are a few of the many known examples of these important membrane components. In this exercise, students examine the cell location and properties of the receptor for the lectin concanavalin A. In the first experiment of the series, students use a concanavalin A-peroxidase complex in a microscopic assay to show that the specific receptor is found on the surface of their own cheek epithelial cells. In the second part of the exercise, students study the characteristic hemagglutination reaction that is elicited by concanavalin A and learn that the reaction is due to multiple sites for receptor binding on the concanavalin A molecule. It is known that concanavalin A binds selectively to mannose residues on the cell-surface glycoprotein receptor. This specificity is confirmed in the final experiment of the ...
D-[1-13C;1-2H]mannose Carbon-13 and deuterium labeled isotope structure | OmicronD-[1-13C;1-2H]mannose Carbon-13 and deuterium labeled isotope structure | Omicron
Supplier pricing and chemical structure of high purity D-[1-13C;1-2H]mannose a stable Carbon-13 and deuterium (2H) labeled isotope from Omicron Biochemicals, Inc.
Effect of clearance of bacteria from the blood on the development of systemic bacteraemia in mice. - Semantic ScholarEffect of clearance of bacteria from the blood on the development of systemic bacteraemia in mice. - Semantic Scholar
Clearance of various bacteria isolated from portal and systemic blood of mice was evaluated and compared. All portal blood strains, including Escherichia coli and enterococci were eliminated more rapidly from the circulation than were strains isolated from systemic blood, including Pseudomonas aeruginosa. With mannose-type lectin, mannose or fucose residues that mediated lectinophagocytosis were detected on the surfaces of most portal strains by agglutination tests. Blood clearance of Esch. coli H21 was inhibited by prior injection of mannose into mice, suggesting that the clearance of this strain was mediated by mannose-type lectin on the surface of tissue macrophages. However, no inhibition of clearance of any other strains was observed by the injection of mannose, galactose, or fucose into mice, nor by pre-incubation of bacteria with mannose. Blood clearance of some portal strains was significantly faster in CBA/J mice than in CBA/N mice with B cell immune deficiency, indicating that immunoglobulin
Lindberg - D-Mannose 500 mg 120 Capsules - Save 40%Lindberg - D-Mannose 500 mg 120 Capsules - Save 40%
Save 40% Lindberg - D-Mannose 500 mg 120 Capsules D-Mannose 500 mg Urinary Tract Support* Anti-Adhesion Properties* D-Mannose is a naturally occurring simple sugar found in some fruits including cranberries, apples, peaches and berries. Due to its unique properties and actions in the body, D-Mannose can support a healthy urinary tract.* D-Mannose, through its anti-adhesion actions in the urinary tract, helps flush particles out into the urine stream.* Because D-Mannose is filtered mostly through the kidneys, it is not metabolized like other sugars and has a minimal impact on blood sugar regulation.* Vegetarian Capsules.
Lindberg - D-Mannose 500 mg 120 Capsules - Save 40%Lindberg - D-Mannose 500 mg 120 Capsules - Save 40%
Save 40% Lindberg - D-Mannose 500 mg 120 Capsules D-Mannose 500 mg Urinary Tract Support* Supports Bladder Health* D-Mannose is a naturally occurring simple sugar found in some fruits including cranberries, apples, peaches and berries. Due to its unique properties and actions in the body, D-Mannose can support a healthy urinary tract.* D-Mannose is used by the body to help cleanse the urinary tract and maintain a healthy bladder lining.* Because D-Mannose is not metabolized like other sugars, it has a minimal impact on blood sugar regulation.* Vegetarian Capsules.
Global D-Mannose Market Outlook 2016-2021Global D-Mannose Market Outlook 2016-2021
D-Mannose is a simple sugar found naturally in many fruits, occurring in high amounts in apples, oranges, peaches, blueberries and cranberries. It is metabolized in small amounts, the remainder of which is excreted via the urine. As it is flushed out of the body, d-mannose maintains a healthy environment for the mucosal surface of the urinary tract.. This report provides detailed analysis of worldwide markets for D-Mannose from 2011-2015 and provides extensive market forecasts 2016-2021 by region/country and subsectors. It covers the key technological and market trends in the D-Mannose market and further lays out an analysis of the factors influencing the supply/demand for D-Mannose, and the opportunities/challenges faced by industry participants. It also acts as an essential tool to companies active across the value chain and to the new entrants by enabling them to capitalize the opportunities and develop business strategies.. GCC?s report, Global D-Mannose Market Outlook 2016-2021, has been ...
Kinetic studies on carbohydrates in alkaline conditions III. Interconversion of D-glucose, D-fructose and D-mannose in feebly...Kinetic studies on carbohydrates in alkaline conditions III. Interconversion of D-glucose, D-fructose and D-mannose in feebly...
The interconversion of glucose, fructose and mannose in sodium carbonate-sodium bicarbonate buffer at pH 10.14 has been studied kinetically at 35 and 50° C. Degradation and the formation of other reducing substances also occur at significant rates and consideration of these reactions was necessary. The ratios of the three sugar concentrations become constant after a sufficient interval of time, and in these conditions the ratio [mannose]/ [glucose + fructose + mannose] was found to be 0.18 approximately, which is higher than has been previously reported. The reactions are shown to be first order in the concentrations of the three sugars, and the results are consistent with a mechanism in which these sugars form a common intermediate. The alternative mechanism, in which fructose is an intermediate in the interconversion of glucose and mannose, is not supported. A comparison with the experiments at much higher alkaiinities reported in parts I and II identifies the common intermediate with the ...
ORBi: Browsing ORBiORBi: Browsing ORBi
in Journal of Biological Chemistry (2008), 283(9), 5708-18. Eukaryotic phosphomannomutases (PMMs) catalyze the interconversion of mannose 6-phosphate to mannose 1-phosphate and are essential to the biosynthesis of GDP-mannose. As such, plant PMMs are involved in ... [more ▼]. Eukaryotic phosphomannomutases (PMMs) catalyze the interconversion of mannose 6-phosphate to mannose 1-phosphate and are essential to the biosynthesis of GDP-mannose. As such, plant PMMs are involved in ascorbic acid (AsA) biosynthesis and N-glycosylation. We report on the conditional phenotype of the temperature-sensitive Arabidopsis thaliana pmm-12 mutant. Mutant seedlings were phenotypically similar to wild type seedlings when grown at 16-18 degrees C but died within several days after transfer to 28 degrees C. This phenotype was observed throughout both vegetative and reproductive development. Protein extracts derived from pmm-12 plants had lower PMM protein and enzyme activity levels. In vitro biochemical analysis of ...
GENTAUR antibody-antibodies.com The Marketplace for Antibodies : Sorting of mannose 6-phosphate receptors mediated by the GGAs.GENTAUR antibody-antibodies.com The Marketplace for Antibodies : Sorting of mannose 6-phosphate receptors mediated by the GGAs.
antibody-antibodies.com is the marketplace for research antibodies. Find the right antibody for your research needs. Sorting of mannose 6-phosphate receptors mediated by the GGAs.
Pro-Tract D-Mannose Tablets - BodySong BoutiquePro-Tract D-Mannose Tablets - BodySong Boutique
Pro-Tract D-Mannose 60 Tablet Pack Natural Source D-Mannose Each tablet contains 1,000mg d-mannose. The highest potency d-mannose on the market. The worlds natural form, 100% pure, not synthetic.* *These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent d
Asymmetric antibodies and pregnancy.Asymmetric antibodies and pregnancy.
PROBLEM: Asymmetric IgG antibodies (AAb) possess a mannose-rich oligosaccharide residue bound to one of the Fab regions, making them unable to activate immunoeffector mechanisms. The proportion of asymmetric antibodies is increased after prolonged im
Record detailsRecord details
Cry3A gene was modified for enhanced expression in maize and such that the amino acid sequence of the synthetic version of Cry3A is the same as the native protein, except for the modified serine-protease recognition site. The pmi gene encodes the enzyme phosphomannose isomerase (PMI) that allows the plants to utilise mannose as a carbon source and is used as a selectable marker ...
Record detailsRecord details
Cry3A gene was modified for enhanced expression in maize and such that the amino acid sequence of the synthetic version of Cry3A is the same as the native protein, except for the modified serine-protease recognition site. The pmi gene encodes the enzyme phosphomannose isomerase (PMI) that allows the plants to utilise mannose as a carbon source and is used as a selectable marker ...
Viruses | Free Full-Text | A Designed Nested Dimer of Cyanovirin-N Increases Antiviral ActivityViruses | Free Full-Text | A Designed "Nested" Dimer of Cyanovirin-N Increases Antiviral Activity
Cyanovirin-N (CV-N) is an antiviral lectin with potent activity against enveloped viruses, including HIV. The mechanism of action involves high affinity binding to mannose-rich glycans that decorate the surface of enveloped viruses. In the case of HIV, antiviral activity of CV-N is postulated to require multivalent interactions with envelope protein gp120, achieved through a pseudo-repeat of sequence that adopts two near-identical glycan-binding sites, and possibly involves a 3D-domain-swapped dimeric form of CV-N. Here, we present a covalent dimer of CV-N that increases the number of active glycan-binding sites, and we characterize its ability to recognize four glycans in solution. A CV-N variant was designed in which two native repeats were separated by the
D-MANNOSE 500 mg | 60 Vegan Capsules with Potent Cranberry Extract | Prevent & Provide Relief for Occasional UTI Infections |...D-MANNOSE 500 mg | 60 Vegan Capsules with Potent Cranberry Extract | Prevent & Provide Relief for Occasional UTI Infections |...
BLAST EVIL E. COLI OUT OF THE URINARY TRACT WITH NESTED NATURAL D-MANNOSE Concentrated D-Mannose and Organic Cranberry Extract for Natural Urinary Support Natural, Non-GMO & Food-Based: We are relentless about sourcing the best, most natural, most ethically produced ingredients available. The active ingredients in Nested Naturals D-Mannose Plus come…
Buy Solaray D-Mannose w/CranActin - 60 VCapsules - eVitamins AustraliaBuy Solaray D-Mannose w/CranActin - 60 VCapsules - eVitamins Australia
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Cire Trudon Bartolomé Scented Matches 40 sticks - BeautyhabitCire Trudon Bartolomé Scented Matches 40 sticks - Beautyhabit
Cire Trudon Bartolomé Scented Matches 40 sticks. Enjoy complimentary US delivery and free fragrance samples when you buy from Beautyhabit!
Molecules | Free Full-Text | Direct 2,3-O-Isopropylidenation of α-D-Mannopyranosides and the Preparation of 3,6-Branched...Molecules | Free Full-Text | Direct 2,3-O-Isopropylidenation of α-D-Mannopyranosides and the Preparation of 3,6-Branched...
A highly efficient, regioselective method for the direct 2,3-O-isopropylidenation of α-D-mannopyranosides is reported. Treatment of various α-D-mannopyranosides with 0.12 equiv of the TsOH·H2O and 2-methoxypropene at 70 °C gave 2,3-O-isopropylidene-α-D-mannopyranosides directly in 80%~90% yields. Based on this method, a 3,6-branched α-D-mannosyl trisaccharide was prepared in 50.4% total yield using p-nitrophenyl 2,3-O-isopropylidene-α-D-mannopyranoside as the starting material.
minakoustinnafsika: Review D-Mannose 1.75 oz (50 g) Pwdrminakoustinnafsika: Review D-Mannose 1.75 oz (50 g) Pwdr
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What stores carry D-mannose? | Reference.comWhat stores carry D-mannose? | Reference.com
D-mannose, a dietary supplement made from a type of fruit sugar, is available for purchase at most natural health-food stores or supplement stores, according to About.com. It is also available for...
D-Mannose - 50 CapsulesD-Mannose - 50 Capsules
This 50-capsule bottle of D-Mannose may offer support for the functioning of your bladder and urinary tract. Get free shipping from PureFormulas today.
D-Mannose - 50 CapsulesD-Mannose - 50 Capsules
This 50-capsule bottle of D-Mannose may offer support for the functioning of your bladder and urinary tract. Get free shipping from PureFormulas today.
D-Mannose vs. AntibioticsD-Mannose vs. Antibiotics
Just a quick question.... Can you try D-Mannose when on a low-dose antibiotic therapy? I have heard good things about this but im currently on 100mg of Trimethoprim (UK bx) per day and dont want to rock the boat!
D-Mannose : Troo Health CareD-Mannose : Troo Health Care
Yes our D-Mannose is suitable for cats and dogs. It comes in a 2 piece capsule so is easy to pull apart and mix the powder with food. As a suggested dose we ...
MISSHA Ultra WaterfulMISSHA Ultra Waterful
... sorgt für eine ideale Feuchtigkeitsversorgung der Haut. Das sogenannte Bio Essential Fluid (ein Komplex aus Mineralwasser, acht essentiellen Aminosäuren, Lecithin, Ceramide 3 und Mannose) harmonisiert den Feuchtigkeitshaushalt der Haut und lindert Irritationen. Wirkung: intensiv feuchtigkeitsspendend, schützend Hauttyp: trocken bis sehr trocken Alter: ab ca. 18 Jahren
Structure for d-MannoseStructure for d-Mannose
Use or mention of technologies or programs in this web site is not intended to imply recommendation or endorsement by the National Institute of Standards and Technology, nor is it intended to imply that these items are necessarily the best available for the purpose ...
Gennaio 2019Gennaio 2019
This is one of the typical questions after the first D-Mannose intakes. The answer you hope to receive is no, but unfortunately I cannot give you this answer so lightly. It all depends on how yourContinue reading. ...
മൂന്ന് സുന്ദരിമാരും ദിലീപും | Nadodi Mannan, Viji Thampi, Dileep, Ananya, Mythili, Archana Kavi, ദിലീപ്‌, നാടോടി മന്നന്‍,...മൂന്ന് സുന്ദരിമാരും ദിലീപും | Nadodi Mannan, Viji Thampi, Dileep, Ananya, Mythili, Archana Kavi, ദിലീപ്‌, നാടോടി മന്നന്‍,...
2006ല്‍ പുറത്തിറങ്ങിയ ലയണ്‍ എന്ന ഹിറ്റ് ചിത്രത്തിന് ശേഷം ദിലീപ് രാഷ്ട്രീയ നേതാവിന്റെ വേഷത്തിലെത്തുന്ന ചിത്രമാണ് നാടോടി മന്നന്‍. ചിത്രത്തിലെ നായകന്‍ ദിലീപാണ് എന്നത് വ്യക്തമായിരുന്നെങ്കിലും നായികമാരെ പറ്റി അഭ്യൂഹം നിലനിന്നിരുന്നു. ചിത്രത്തില്‍ മൂന്ന് നായികമാരാണ് ഉള്ളതെന്നും റിമയും ഭാവനയും മംമ്തയുമാണ് നായികാ വേഷം കൈകാര്യം ചെയ്യാനെത്തുകയെന്നും വാര്&zwj
Forestry Commission - Picture Library ImageForestry Commission - Picture Library Image
Reference: 2005009. Felling coupes reflecting scale and shape of enclosure pattern, and contributing to positive interlock of open ground to forest. Castle ...
Fibronectin type II domainFibronectin type II domain
GlycanGlycan
Pancreatic islet macrophagePancreatic islet macrophage
Congenital disorder of glycosylationCongenital disorder of glycosylation
Malpuech facial clefting syndromeMalpuech facial clefting syndrome
LINGO1LINGO1
LMAN2LMAN2
Collagen receptorCollagen receptor
LMAN1LMAN1
AcrosinAcrosin
MannosidaseMannosidase
MorpheeinMorpheein
Nyctanthes arbor-tristisNyctanthes arbor-tristis
GalactolysisGalactolysis
GDP-L-fucose synthaseGDP-L-fucose synthase
Thermococcus litoralisThermococcus litoralis
L-iditol 2-dehydrogenaseL-iditol 2-dehydrogenase
GDP-6-deoxy-D-talose 4-dehydrogenaseGDP-6-deoxy-D-talose 4-dehydrogenase
Mannitol-1-phosphate 5-dehydrogenaseMannitol-1-phosphate 5-dehydrogenase
L-fucose isomeraseL-fucose isomerase
Sorbitol-6-phosphate 2-dehydrogenaseSorbitol-6-phosphate 2-dehydrogenase
L-rhamnonate dehydrataseL-rhamnonate dehydratase
Poly(beta-D-mannuronate) lyasePoly(beta-D-mannuronate) lyase
L-FuculokinaseL-Fuculokinase
L-rhamnose 1-dehydrogenaseL-rhamnose 1-dehydrogenase
1-phosphofructokinase1-phosphofructokinase
AltroseAltrose
LMAN2LLMAN2L
L-rhamnono-1,4-lactonaseL-rhamnono-1,4-lactonase
Alginate synthaseAlginate synthase
AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation Science
MannoseMannose-Binding LectinsReceptor, IGF Type 2MannosephosphatesGuanosine Diphosphate MannoseDolichol Monophosphate MannoseOligosaccharidesMannosyltransferasesMannose-6-Phosphate IsomeraseLectins, C-TypeMannansCarbohydratesHexosephosphatesMannosidasesPolyisoprenyl Phosphate SugarsReceptors, Cell SurfaceMannosidesCarbohydrate SequenceMonosaccharidesPolysaccharidesGlycoproteinsGlycosylationalpha-MannosidasePolyisoprenyl Phosphate MonosaccharidesGlucosamineGalactoseCarbohydrate ConformationGlycopeptidesLectinsLysosomesFucoseDolichol PhosphatesMethylmannosidesHexosesAcetylglucosamineMolecular Sequence DataPhosphotransferases (Phosphomutases)Cathepsin DCarbohydrate MetabolismMannose-Binding LectinPolyisoprenyl Phosphate OligosaccharidesHexosaminidasesGlycoside Hydrolasesbeta-MannosidaseSwainsonineMannosyl-Glycoprotein Endo-beta-N-AcetylglucosaminidaseEndocytosisGlucuronidaseNucleoside Diphosphate SugarsPlant LectinsGlycolipidsDolicholKineticsPhosphoenolpyruvate Sugar Phosphotransferase SystemGolgi ApparatusCollectinsAmino Acid SequenceTunicamycinCongenital Disorders of GlycosylationMolecular WeightImino Furanoses1-DeoxynojirimycinGlucoseChromatography, PaperMucolipidosesChromatography, AffinityCell LineIndolizinesInsulin-Like Growth Factor IIMacrophagesChromatography, GelAsparagineGlycosylphosphatidylinositolsAcetylglucosaminidaseElectrophoresis, Polyacrylamide GelBiological TransportHexosaminesCricetinaeCarbohydrate Metabolism, Inborn ErrorsPeptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidasebeta-N-AcetylhexosaminidasesAcetylgalactosaminealpha-GlucosidasesEndosomesChromatography, Thin LayerProtein Processing, Post-TranslationalCell MembraneFructoseFlocculationTransferases (Other Substituted Phosphate Groups)GalanthusAmino AcidsFructokinasesLiverCarrier ProteinsCell Walltrans-Golgi NetworkCells, CulturedLigandsGuanosine Diphosphate SugarsProtein BindingMembrane GlycoproteinsUridine Diphosphate N-AcetylglucosamineRhamnoseEndoplasmic ReticulumMutationCationsRecombinant ProteinsXyloseConcanavalin ASugar AlcoholsDeoxy SugarsFibroblastsBinding SitesSubstrate SpecificityCattlePolyisoprenyl PhosphatesMagnetic Resonance SpectroscopyReceptors, MitogenReceptors, ImmunologicChromatography, Ion ExchangePinocytosisGlycoconjugates
Mannose | Portsmouth Regional HospitalMannose | Portsmouth Regional Hospital
Mannose - wikidocMannose - wikidoc
D Mannose - Now at VitaDigest.com - Great Selection of D Mannose ProductsD Mannose - Now at VitaDigest.com - Great Selection of D Mannose Products
Free E-Book on UTI-Slip D-Mannose Preview | Wellness PartnersFree E-Book on UTI-Slip D-Mannose Preview | Wellness Partners
Recombinant Prokaryotic Lectin RPL with specificity for Terminal Mannose: RPL-Man2, L-007-2MG | AMSBIORecombinant Prokaryotic Lectin RPL with specificity for Terminal Mannose: RPL-Man2, L-007-2MG | AMSBIO
D-Mannose Urinary Tract Cleanse 120 Capsules 500 mg D Mannose NOW Foods - Compare Price and Reviews at VitaDigest.comD-Mannose Urinary Tract Cleanse 120 Capsules 500 mg D Mannose NOW Foods - Compare Price and Reviews at VitaDigest.com
Problems with D Mannose making me sick.. - Bladder Health UK ForumsProblems with D Mannose making me sick.. - Bladder Health UK Forums
4-O-β-D-galactopyranosyl-D-[1-13C]mannose - Creative Proteomics4-O-β-D-galactopyranosyl-D-[1-13C]mannose - Creative Proteomics
D-Mannose, Supplements categoryD-Mannose, Supplements category
D-Mannose | Superior LabsD-Mannose | Superior Labs
D-[UL-2H7]mannose - Creative ProteomicsD-[UL-2H7]mannose - Creative Proteomics
D-Mannose With Cranactin - Solaray | SanavitaD-Mannose With Cranactin - Solaray | Sanavita
D-mannose - Purchase High Quality D-mannoseD-mannose - Purchase High Quality D-mannose
Mannose impairs tumor growth and enhance chemotherapy<...Mannose impairs tumor growth and enhance chemotherapy<...
SOLARAY: Solaray D-Mannose w/CranActin - 1000 mg - 120 Veg CapSOLARAY: Solaray D-Mannose w/CranActin - 1000 mg - 120 Veg Cap
D-MANNOSE WITH CRANACTIN - tratament infectii urinare - P.M. INNOVATION LABORATORIES SRLD-MANNOSE WITH CRANACTIN - tratament infectii urinare - P.M. INNOVATION LABORATORIES SRL
Mannose - WikipediaMannose - Wikipedia
Mannose receptor - WikipediaMannose receptor - Wikipedia
D-mannose (CHEBI:16024)D-mannose (CHEBI:16024)
Mannose-binding lectin deficiency: MedlinePlus GeneticsMannose-binding lectin deficiency: MedlinePlus Genetics
D-Mannose | The Merck Index OnlineD-Mannose | The Merck Index Online
GDP-alpha-D-mannose (CHEBI:15820)GDP-alpha-D-mannose (CHEBI:15820)
d-Mannosed-Mannose
α-Mannose, TMSα-Mannose, TMS
D-Mannose - iHerbD-Mannose - iHerb
Mannose-based fast dissolving tablets - Fu, YourongMannose-based fast dissolving tablets - Fu, Yourong
Mannose-6-phosphate receptors definition | Drugs.comMannose-6-phosphate receptors definition | Drugs.com
What stores carry D-mannose? | Reference.comWhat stores carry D-mannose? | Reference.com
Complement Pathway, Mannose-Binding Lectin - MeSH - NCBIComplement Pathway, Mannose-Binding Lectin - MeSH - NCBI
Bladapure D-Mannose Capsules | Holland & BarrettBladapure D-Mannose Capsules | Holland & Barrett
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What is d-mannose? | Naked Science ForumWhat is d-mannose? | Naked Science Forum
D-MANNOSE: User ratings for effectiveness, side effects, safety and interactions - WebMDD-MANNOSE: User ratings for effectiveness, side effects, safety and interactions - WebMD
Impact of mannose-binding lectin on susceptibility to infectious diseases. - PubMed - NCBIImpact of mannose-binding lectin on susceptibility to infectious diseases. - PubMed - NCBI
D-Mannose for UTI Prevention Validated in a Clinical TrialD-Mannose for UTI Prevention Validated in a Clinical Trial
PatientsLikeMe | D-Mannose report for patients like youPatientsLikeMe | D-Mannose report for patients like you
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Diagnosed with low MBL (mannose-binding lectin) deficiency - Autoimmune Disorders - MedHelpDiagnosed with low MBL (mannose-binding lectin) deficiency - Autoimmune Disorders - MedHelp
Search of: MANNOSE-BINDING PROTEIN DEFICIENCY - Results on Map - ClinicalTrials.govSearch of: MANNOSE-BINDING PROTEIN DEFICIENCY - Results on Map - ClinicalTrials.gov
Mannose Binding Lectin, SerumMannose Binding Lectin, Serum
D-Mannose vs. AntibioticsD-Mannose vs. Antibiotics
D-Mannose | GreenMedInfo | Substance | Natural Medicine | AlternativeD-Mannose | GreenMedInfo | Substance | Natural Medicine | Alternative
AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation Science
MannoseMannose-Binding LectinsReceptor, IGF Type 2MannosephosphatesGuanosine Diphosphate MannoseDolichol Monophosphate MannoseOligosaccharidesMannosyltransferasesMannose-6-Phosphate IsomeraseLectins, C-TypeMannansCarbohydratesHexosephosphatesMannosidasesPolyisoprenyl Phosphate SugarsReceptors, Cell SurfaceMannosidesCarbohydrate SequenceMonosaccharidesPolysaccharidesGlycoproteinsGlycosylationalpha-MannosidasePolyisoprenyl Phosphate MonosaccharidesGlucosamineGalactoseCarbohydrate ConformationGlycopeptidesLectinsLysosomesFucoseDolichol PhosphatesMethylmannosidesHexosesAcetylglucosamineMolecular Sequence DataPhosphotransferases (Phosphomutases)Cathepsin DCarbohydrate MetabolismMannose-Binding LectinPolyisoprenyl Phosphate OligosaccharidesHexosaminidasesGlycoside Hydrolasesbeta-MannosidaseSwainsonineMannosyl-Glycoprotein Endo-beta-N-AcetylglucosaminidaseEndocytosisGlucuronidaseNucleoside Diphosphate SugarsPlant LectinsGlycolipidsDolicholKineticsPhosphoenolpyruvate Sugar Phosphotransferase SystemGolgi ApparatusCollectinsAmino Acid SequenceTunicamycinCongenital Disorders of GlycosylationMolecular WeightImino Furanoses1-DeoxynojirimycinGlucoseChromatography, PaperMucolipidosesChromatography, AffinityCell LineIndolizinesInsulin-Like Growth Factor IIMacrophagesChromatography, GelAsparagineGlycosylphosphatidylinositolsAcetylglucosaminidaseElectrophoresis, Polyacrylamide GelBiological TransportHexosaminesCricetinaeCarbohydrate Metabolism, Inborn ErrorsPeptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidasebeta-N-AcetylhexosaminidasesAcetylgalactosaminealpha-GlucosidasesEndosomesChromatography, Thin LayerProtein Processing, Post-TranslationalCell MembraneFructoseFlocculationTransferases (Other Substituted Phosphate Groups)GalanthusAmino AcidsFructokinasesLiverCarrier ProteinsCell Walltrans-Golgi NetworkCells, CulturedLigandsGuanosine Diphosphate SugarsProtein BindingMembrane GlycoproteinsUridine Diphosphate N-AcetylglucosamineRhamnoseEndoplasmic ReticulumMutationCationsRecombinant ProteinsXyloseConcanavalin ASugar AlcoholsDeoxy SugarsFibroblastsBinding SitesSubstrate SpecificityCattlePolyisoprenyl PhosphatesMagnetic Resonance SpectroscopyReceptors, MitogenReceptors, ImmunologicChromatography, Ion ExchangePinocytosisGlycoconjugates
Slip D-Mannose Veggie CapsulesCapsulesCranActinPowderGlucosePhosphateFoodsBacteriaSugarsUrineUrinary tract infeInfectionsApoptosisColiNaturallyAmountsWidelyFormationHumanReceptorOligosaccharidesSugars500mgAmounts of D-mannoseSource NaturalsCarbohydrateBinding LectinDietary SupplementUrinary tract infSupplementReceptorsPathwayIngredientsProteinPure EncapsulationsMetabolismLectinsAntibioticsCranberriesMonosaccharideHealthy urinary tractAmount of mannoseBody'sGLYCANProteinsLysosomal hydrolasesUTIsBiosynthesisSearchAscorbyl palmitateSugar
Slip D-Mannose Veggie Capsules1
Capsules2
CranActin1
Powder6
Glucose2
Phosphate2
  • The acquisition of mannose 6-phosphate (Man6P) on N-linked glycans of lysosomal enzymes is a structural requirement for their transport from the Golgi apparatus to lysosomes mediated by the mannose 6-phosphate receptors, 300 kDa cation-independent mannose 6-phosphate receptor (MPR300) and 46 kDa cation-dependent mannose 6-phosphate receptor (MPR46). (harvard.edu)
  • Single crystal X-ray diffraction analysis to 2.7 Å resolution of Fv M6P-1 in complex with Man6P reveals that specificity and affinity is achieved via multiple hydrogen bonds to the mannose ring and two salt bridges to the phosphate moiety. (harvard.edu)
Foods1
Bacteria4
  • The idea that mannose supplements can help prevent or treat bladder infections derives from a property of the E. coli bacteria. (portsmouthhospital.com)
  • Reasoning from this fact of basic science, medical researchers in the 1980s hypothesized that consumption of mannose as a supplement will increase levels of mannose in the urine to such an extent that this free mannose will saturate the E. coli's mannose-binding pili and thereby make the bacteria unable to grapple onto the cells of the bladder wall. (portsmouthhospital.com)
  • 1 When these pili are saturated by mannose, white blood cells (specifically, macrophages) are less able to consume the E. coli bacteria. (portsmouthhospital.com)
  • 3-4 Third, there are numerous other bacteria that cause bladder infections, and these are not known or suspected to have mannose-sensitive pili. (portsmouthhospital.com)
Sugars1
  • D-Mannose is a monosaccharide hexose sugar that is part of the family of sugars in the aldohexose series. (superiorlabs.com)
Urine1
  • Even though, human bodies are able to metabolize only a small amount of D-Mannose, much of this is eliminated through urine. (vitadigest.com)
Urinary tract infe2
  • Relying on evidence that is both exceedingly preliminary and highly inconsistent, some alternative medicine practitioners have popularized mannose as a treatment for urinary tract infections. (portsmouthhospital.com)
  • D-Mannose is a naturally secreting sugar, which is safe and best alternative to cure UTIs (urinary tract infections). (vitadigest.com)
Infections5
Apoptosis1
  • It was found that mannose showed potential anticancer effects against NSCLC cells in vitro by inhibiting proliferation, inducing G0/G1 cell cycle arrest, promoting cisplatin‑induced apoptosis and decreasing the invasive abilities. (omgcb.com)
Coli4
  • Many, though not all, strains of E. coli have the ability to attach to the mannose present in the wall of the bladder by means of thread-like structures called pili. (portsmouthhospital.com)
  • First, one of the main ways that the body's white blood cells recognize and kill E. coli is via these mannose-sensitive pili. (portsmouthhospital.com)
  • 2 Second, many species of E. coli , including some of the most dangerous, do not have mannose-sensitive pili at all. (portsmouthhospital.com)
  • However, with the presence of D-mannose, Escherichia coli preferably stick on to D-Mannose particles forming a compound that is ejected through excretion. (vitadigest.com)
Naturally1
Amounts1
  • Very weak evidence from test tube studies hints that consumption of gigantic amounts of mannose by pregnant women could conceivably increase risk of birth defects in their offspring. (portsmouthhospital.com)
Widely1
  • The name Manapol is derived from the mannose polyoses found widely in clean Aloe gel. (vitadigest.com)
Formation1
Human2
Receptor38
Oligosaccharides5
Sugars6
  • It appears that your body can produce all the mannose it needs from other sugars in your diet, so you shouldn't need to take any of it. (thenakedscientists.com)
  • Find the foundation of all the essential sugars with Spectrum's large inventory of mannose sugars. (spectrumchemical.com)
  • Spectrum specializes in providing the top mannose sugars but if you do not see the product, grade or form of the ingredient you require, just contact our chemical specialist at 800-772-8786. (spectrumchemical.com)
  • Since D-Mannose is processed differently than other types of sugars‚ it's less likely to cause a rapid sugar rush (and subsequent crash). (pureformulas.com)
  • Because D-Mannose is not metabolized like other sugars, it has a minimal impact on blood sugar regulation. (nutritionexpress.com)
  • D-Mannose is one of the simple sugars naturally found in cranberries and pineapples known for its ability to protect and nourish the urinary tract. (tasmanhealth.co.nz)
500mg3
Amounts of D-mannose5
Source Naturals6
Carbohydrate2
  • C-type (Ca(2+)-dependent) animal lectins such as mannose-binding proteins mediate many cell-surface carbohydrate-recognition events. (nih.gov)
  • The crystal structure at 1.7 A resolution of the carbohydrate-recognition domain of rat mannose-binding protein complexed with an oligomannose asparaginyl-oligosaccharide reveals that Ca2+ forms coordination bonds with the carbohydrate ligand. (nih.gov)
Binding Lectin26
Dietary Supplement1
Urinary tract inf1
Supplement6
Receptors4
  • The delivery of soluble hydrolases to lysosomes is mediated by the cation-independent and cation-dependent mannose 6-phosphate receptors. (sciencemag.org)
  • Thus, the GGAs appear to mediate sorting of the mannose 6-phosphate receptors at the trans-Golgi network. (sciencemag.org)
  • Both mannose 6-phosphate receptors (MPRs) mediate recruitment of the lysosomal hydrolases to clathrin-coated areas of the TGN, from which carrier vesicles deliver the MPR-hydrolase complexes to endosomes. (sciencemag.org)
  • Mannose 6-phosphate receptors (MPRs) transport newly synthesized lysosomal hydrolases from the Golgi to prelysosomes and then return to the Golgi for another round of transport. (nih.gov)
Pathway1
  • In this study, we enhanced the biocontrol abilities of T. atroviride P1 against plant pathogens by overexpressing the Saccharomyces cerevisiae DPM1 gene coding for dolichyl phosphate mannose (DPM) synthase, a key enzyme in the O-glycosylation pathway. (apsnet.org)
Ingredients2
Protein5
  • It is initiated by the en bloc transfer on Glc3Man9GlcNAc2 to nascent glycoproteins in the endoplasmic reticulum in a co-translational manner as the protein entered through the transport system. (wikipedia.org)
  • Functional mannose-binding lectins are made up of two to six protein groups called trimers, which are each composed of three of the protein pieces (subunits) produced from the MBL2 gene. (medlineplus.gov)
  • Mannose-binding protein is also an acute phase reactant produced by the liver. (uiowa.edu)
  • Patients who have abnormal levels of mannose-binding protein may have recurrent significant infections in the absence of abnormalities in the four major arms of the immune system. (uiowa.edu)
  • Abnormal mannose-binding protein concentrations have been found in patients with infectious disorders such as tuberculosis, hepatitis B, and in autoimmune disorders including recurrent spontaneous abortion and systemic lupus erythematosis. (uiowa.edu)
Pure Encapsulations1
Metabolism3
Lectins1
Antibiotics5
  • Although D-mannose has promising attributes, antibiotics are still the most effective course of treatment to get rid of the infection and prevent it from spreading to the kidneys. (reference.com)
  • My urologist suggested that I try d-mannose after a year of battling E. Coli urinary tract infections treated with antibiotics followed by the UTI returning. (consumerlab.com)
  • Combination of cranberry extract and D-mannose - possible enhancer of uropathogen sensitivity to antibiotics in acute therapy of urinary tract infections. (greenmedinfo.com)
  • D-mannose by Bio-Tech Pharmacal is very effective at treating and preventing bladder infections, d-mannose has worked far better for me then antibiotics and is a completely natural therapy, which is a huge plus! (pureformulas.com)
  • Unlike antibiotics, D-Mannose may actually improve conditions for intestinal flora and probiotics to flourish, creating a healthy environment for digestion and nutrient absorption. (allstarhealth.com)
Cranberries5
Monosaccharide4
Healthy urinary tract3
  • D-Mannose is a natural sugar that has been studied for its potential ability to support a normal, healthy urinary tract. (fredmeyer.com)
  • Clinical studies have demonstrated that when taken regularly, D-Mannose can help to maintain a healthy urinary tract. (picknsave.com)
  • Due to its unique properties and actions in the body, D-mannose can support a healthy urinary tract. (nutritionexpress.com)
Amount of mannose2
  • 1. A fast-dissolving pharmaceutical tablet comprising a dissolution-effective amount of mannose, which tablet has a hardness of at least about 20 newtons and which disintegrates within about 30 seconds in the presence of an amount of water sufficient to soak the tablet. (freepatentsonline.com)
  • 2. The tablet of claim 1, wherein the dissolution-effective amount of mannose ranges from about 1% to about 100% by weight of the tablet. (freepatentsonline.com)
Body's3
  • First, one of the main ways that the body's white blood cells recognize and kill E. coli is via these mannose-sensitive pili. (portsmouthhospital.com)
  • This syndrome is an inherited metabolic disorder that interferes with the body's ability to properly break down and produce mannose. (pureformulas.com)
  • In the urinary tract, D-mannose complements the body's natural elimination process by maintaining a healthy environment in the bladder. (nowfoods.com)
GLYCAN1
  • Also: "Human plasma contains ~50μM mannose which is primarily derived from N-glycan processing . (cancercompass.com)
Proteins2
Lysosomal hydrolases1
  • Lysosomal hydrolases are posttranslationally modified in the Golgi complex by the addition of mannose 6-phosphate groups that function as signals for sorting to lysosomes ( 1 ). (sciencemag.org)
UTIs6
  • MY mother suffered from recurrent UTIs until she started using D Mannose. (consumerlab.com)
  • The combination of D-mannose, inulin, cranberry, bearberry, Olea europaea, Orthosiphon and Lactobacillus acidophilus SGL 11 per os represents a useful therapy for recurrent UTIs. (greenmedinfo.com)
  • In this pilot study the aim was to evaluate if oral D Mannose could be used as a safe and effective treatment and as a prophylactic measure for recurrent UTIs in adult women. (clinicaltrials.gov)
  • D-mannose can help cure more than 90 percent of all UTIs within 1 to 2 days! (healthimpactnews.com)
  • Before discovering D-Mannose, I would get several UTIs a year and switch to either Bactrim or Levaquin to cure the infection. (allstarhealth.com)
  • I believe the D-Mannose is the reason I have less UTIs. (allstarhealth.com)
Biosynthesis1
  • Biosynthesis of mammalian O-mannosyl glycans is initiated by the transfer of mannose from mannose-P-Dol to serine or threonine residue, followed by extensions with N-acetylglucosamine (GlcNAc) and galactose (Gal) to generate core M1, M2 and M3 glycans. (genome.jp)
Search1
  • http://www.functionalglycomics.org/glycomics/search/jsp/result.jsp?query=mannose%20AND%20receptor&cat=coreh here]. (functionalglycomics.org)
Ascorbyl palmitate1
Sugar2
Free E-Book on UTI-Slip D-Mannose Preview | Wellness Partners
Free E-Book on UTI-Slip D-Mannose Preview | Wellness Partners (wellnesspartners.com)
D Mannose - Now at VitaDigest.com - Great Selection of D Mannose Products
D Mannose - Now at VitaDigest.com - Great Selection of D Mannose Products (vitadigest.com)
Clear Tract D-Mannose Maintains Healthy Urinary Tract Capsules - 60 Ea | Myotcstore.com
Clear Tract D-Mannose Maintains Healthy Urinary Tract Capsules - 60 Ea | Myotcstore.com (myotcstore.com)
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Quiz my ideal man nose, how to bring my lover back to me download, how to get back with your ex lover redfern, star trek online... (s3-us-west-1.amazonaws.com)
D-Mannose | The Merck Index Online
D-Mannose | The Merck Index Online (rsc.org)
D-MANNOSE - Stadtapotheke Zaversky - Knittelfeld
D-MANNOSE - Stadtapotheke Zaversky - Knittelfeld (zaversky.at)
Spider-Man
Spider-Man (noseinabook.co.uk)
D-MANNOSE: User ratings for effectiveness, side effects, safety and interactions - WebMD
D-MANNOSE: User ratings for effectiveness, side effects, safety and interactions - WebMD (webmd.com)
D-Mannose
D-Mannose (webbook.nist.gov)
How Cranberry Can Help Fight Off UTIs | Holland & Barrett
How Cranberry Can Help Fight Off UTIs | Holland & Barrett (hollandandbarrett.com)
English</span> </span>
English</span> </span> (aestheticturkey.com)
D-Mannose | GreenMedInfo | Substance | Natural Medicine | Alternative
D-Mannose | GreenMedInfo | Substance | Natural Medicine | Alternative (greenmedinfo.com)
Bowel Cancer News, Research - Page 2
Bowel Cancer News, Research - Page 2 (news-medical.net)
D Mannose in Recurrent Urinary Tract Infections - Tabular View - ClinicalTrials.gov
D Mannose in Recurrent Urinary Tract Infections - Tabular View - ClinicalTrials.gov (clinicaltrials.gov)
PriceGrabber - Uti test Vitamins & Nutrition
PriceGrabber - Uti test Vitamins & Nutrition (pricegrabber.com)
D-Mannose For Bladder Wellness | San Diego, CA | West Coast Mint
D-Mannose For Bladder Wellness | San Diego, CA | West Coast Mint (westcoastmint.com)
Is 7500 Steps A Day Good | Does Gnc Carry D Mannose
Is 7500 Steps A Day Good | Does Gnc Carry D Mannose (loseweightnation.com)
GDP-4-dehydro-6-deoxy-alpha-D-mannose (CHEBI:16955)
GDP-4-dehydro-6-deoxy-alpha-D-mannose (CHEBI:16955) (ebi.ac.uk)
Natural Health Information Articles and Health Newsletter by Dr. Joseph Mercola
Natural Health Information Articles and Health Newsletter by Dr. Joseph Mercola (mercola.com)
LMAN2 Gene - GeneCards | LMAN2 Protein | LMAN2 Antibody
LMAN2 Gene - GeneCards | LMAN2 Protein | LMAN2 Antibody (genecards.org)
POMK gene - Genetics Home Reference - NIH
POMK gene - Genetics Home Reference - NIH (ghr.nlm.nih.gov)
Tangled bank of experimentally evolved Burkholderia biofilms reflects selection during chronic infections | PNAS
Tangled bank of experimentally evolved Burkholderia biofilms reflects selection during chronic infections | PNAS (pnas.org)
Dr. Wright's Protocol: D-Mannose And SSKI For UTI Treatment - Stop UTI forever
Dr. Wright's Protocol: D-Mannose And SSKI For UTI Treatment - Stop UTI forever (stoputiforever.com)
Specialty Ingredients / D-Mannose - Nutraceuticals World
Specialty Ingredients / D-Mannose - Nutraceuticals World (nutraceuticalsworld.com)
Urinary Tract Infection | Natural UTI Treatment | d-Mannose - HerAnswer.com
Urinary Tract Infection | Natural UTI Treatment | d-Mannose - HerAnswer.com (heranswer.com)
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Nose Trimmer, Nose Trimmer Suppliers and Manufacturers at Alibaba.com (alibaba.com)
RCSB PDB - 6FMG: Structure of the Mannose Transporter IIA Domain from Streptococcus pneumoniae
RCSB PDB - 6FMG: Structure of the Mannose Transporter IIA Domain from Streptococcus pneumoniae (rcsb.org)
D-Mannose for UTI Prevention Validated in a Clinical Trial
D-Mannose for UTI Prevention Validated in a Clinical Trial (articles.mercola.com)
Possible role of L-form switching in recurrent urinary tract infection | Nature Communications
Possible role of L-form switching in recurrent urinary tract infection | Nature Communications (nature.com)
Products: Cranberry/d-Mannose - The Way Up
Products: Cranberry/d-Mannose - The Way Up (thewayup.com)
Sonatera | The PinotFile
Sonatera | The PinotFile (princeofpinot.com)