An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Inhaling and exhaling the smoke of burning TOBACCO.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
Important enzymes in the ALTERNATIVE COMPLEMENT ACTIVATION PATHWAY. They cleave COMPLEMENT C3 and COMPLEMENT C5.
The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.
The comparative and theoretical study of culture, often synonymous with cultural anthropology.
A condition with abnormally high levels of CHOLESTEROL in the blood. It is defined as a cholesterol value exceeding the 95th percentile for the population.
Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
A status with BODY WEIGHT that is grossly above the acceptable or desirable weight, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.
The probability that an event will occur. It encompasses a variety of measures of the probability of a generally unfavorable outcome.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.
Elements of limited time intervals, contributing to particular results or situations.
The ratio of two odds. The exposure-odds ratio for case control data is the ratio of the odds in favor of exposure among cases to the odds in favor of exposure among noncases. The disease-odds ratio for a cohort or cross section is the ratio of the odds in favor of disease among the exposed to the odds in favor of disease among the unexposed. The prevalence-odds ratio refers to an odds ratio derived cross-sectionally from studies of prevalent cases.
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.
Maleness or femaleness as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or effect of a circumstance. It is used with human or animal concepts but should be differentiated from SEX CHARACTERISTICS, anatomical or physiological manifestations of sex, and from SEX DISTRIBUTION, the number of males and females in given circumstances.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
The offspring in multiple pregnancies (PREGNANCY, MULTIPLE): TWINS; TRIPLETS; QUADRUPLETS; QUINTUPLETS; etc.
A single nucleotide variation in a genetic sequence that occurs at appreciable frequency in the population.
VASCULAR DISEASES that are associated with DIABETES MELLITUS.
Tumors or cancer of the LIVER.
The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level.
A potent hepatotoxic and hepatocarcinogenic mycotoxin produced by the Aspergillus flavus group of fungi. It is also mutagenic, teratogenic, and causes immunosuppression in animals. It is found as a contaminant in peanuts, cottonseed meal, corn, and other grains. The mycotoxin requires epoxidation to aflatoxin B1 2,3-oxide for activation. Microsomal monooxygenases biotransform the toxin to the less toxic metabolites aflatoxin M1 and Q1.
A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
The frequency of different ages or age groups in a given population. The distribution may refer to either how many or what proportion of the group. The population is usually patients with a specific disease but the concept is not restricted to humans and is not restricted to medicine.
The number of males and females in a given population. The distribution may refer to how many men or women or what proportion of either in the group. The population is usually patients with a specific disease but the concept is not restricted to humans and is not restricted to medicine.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
An infant during the first month after birth.
Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with LONGITUDINAL STUDIES which are followed over a period of time.
Variant forms of the same gene, occupying the same locus on homologous CHROMOSOMES, and governing the variants in production of the same gene product.
A major and the second most common isoform of apolipoprotein E. In humans, Apo E4 differs from APOLIPOPROTEIN E3 at only one residue 112 (cysteine is replaced by arginine), and exhibits a lower resistance to denaturation and greater propensity to form folded intermediates. Apo E4 is a risk factor for ALZHEIMER DISEASE and CARDIOVASCULAR DISEASES.
Conditions or pathological processes associated with the disease of diabetes mellitus. Due to the impaired control of BLOOD GLUCOSE level in diabetic patients, pathological processes develop in numerous tissues and organs including the EYE, the KIDNEY, the BLOOD VESSELS, and the NERVE TISSUE.
Cholesterol which is contained in or bound to low density lipoproteins (LDL), including CHOLESTEROL ESTERS and free cholesterol.
A condition in which albumin level in blood (SERUM ALBUMIN) is below the normal range. Hypoalbuminemia may be due to decreased hepatic albumin synthesis, increased albumin catabolism, altered albumin distribution, or albumin loss through the urine (ALBUMINURIA).
A country spanning from central Asia to the Pacific Ocean.
The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.
A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).
A 34-kDa glycosylated protein. A major and most common isoform of apolipoprotein E. Therefore, it is also known as apolipoprotein E (ApoE). In human, Apo E3 is a 299-amino acid protein with a cysteine at the 112 and an arginine at the 158 position. It is involved with the transport of TRIGLYCERIDES; PHOSPHOLIPIDS; CHOLESTEROL; and CHOLESTERYL ESTERS in and out of the cells.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
An indicator of body density as determined by the relationship of BODY WEIGHT to BODY HEIGHT. BMI=weight (kg)/height squared (m2). BMI correlates with body fat (ADIPOSE TISSUE). Their relationship varies with age and gender. For adults, BMI falls into these categories: below 18.5 (underweight); 18.5-24.9 (normal); 25.0-29.9 (overweight); 30.0 and above (obese). (National Center for Health Statistics, Centers for Disease Control and Prevention)
A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.
INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact.
Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.
Individuals whose ancestral origins are in the southeastern and eastern areas of the Asian continent.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
Individuals whose ancestral origins are in the continent of Europe.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Cholesterol which is contained in or bound to high-density lipoproteins (HDL), including CHOLESTEROL ESTERS and free cholesterol.
Conditions with excess LIPIDS in the blood.
The proportion of one particular in the total of all ALLELES for one genetic locus in a breeding POPULATION.
Behaviors associated with the ingesting of alcoholic beverages, including social drinking.
A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA.
Typical way of life or manner of living characteristic of an individual or group. (From APA, Thesaurus of Psychological Index Terms, 8th ed)
Diminished effectiveness of INSULIN in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent HYPERGLYCEMIA or KETOSIS.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
Regular course of eating and drinking adopted by a person or animal.
An important soluble regulator of the alternative pathway of complement activation (COMPLEMENT ACTIVATION PATHWAY, ALTERNATIVE). It is a 139-kDa glycoprotein expressed by the liver and secreted into the blood. It binds to COMPLEMENT C3B and makes iC3b (inactivated complement 3b) susceptible to cleavage by COMPLEMENT FACTOR I. Complement factor H also inhibits the association of C3b with COMPLEMENT FACTOR B to form the C3bB proenzyme, and promotes the dissociation of Bb from the C3bBb complex (COMPLEMENT C3 CONVERTASE, ALTERNATIVE PATHWAY).
Generic term for diseases caused by an abnormal metabolic process. It can be congenital due to inherited enzyme abnormality (METABOLISM, INBORN ERRORS) or acquired due to disease of an endocrine organ or failure of a metabolically important organ such as the liver. (Stedman, 26th ed)
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries.
A class of protein components which can be found in several lipoproteins including HIGH-DENSITY LIPOPROTEINS; VERY-LOW-DENSITY LIPOPROTEINS; and CHYLOMICRONS. Synthesized in most organs, Apo E is important in the global transport of lipids and cholesterol throughout the body. Apo E is also a ligand for LDL receptors (RECEPTORS, LDL) that mediates the binding, internalization, and catabolism of lipoprotein particles in cells. There are several allelic isoforms (such as E2, E3, and E4). Deficiency or defects in Apo E are causes of HYPERLIPOPROTEINEMIA TYPE III.
The genetic constitution of individuals with respect to one member of a pair of allelic genes, or sets of genes that are closely linked and tend to be inherited together such as those of the MAJOR HISTOCOMPATIBILITY COMPLEX.
INFLAMMATION of the LIVER in humans caused by HEPATITIS C VIRUS, a single-stranded RNA virus. Its incubation period is 30-90 days. Hepatitis C is transmitted primarily by contaminated blood parenterally, and is often associated with transfusion and intravenous drug abuse. However, in a significant number of cases, the source of hepatitis C infection is unknown.
The return of a sign, symptom, or disease after a remission.
Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.
Research techniques that focus on study designs and data gathering methods in human and animal populations.
Pathological conditions involving the HEART including its structural and functional abnormalities.
Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
Substances used to lower plasma CHOLESTEROL levels.
A spiral bacterium active as a human gastric pathogen. It is a gram-negative, urease-positive, curved or slightly spiral organism initially isolated in 1982 from patients with lesions of gastritis or peptic ulcers in Western Australia. Helicobacter pylori was originally classified in the genus CAMPYLOBACTER, but RNA sequencing, cellular fatty acid profiles, growth patterns, and other taxonomic characteristics indicate that the micro-organism should be included in the genus HELICOBACTER. It has been officially transferred to Helicobacter gen. nov. (see Int J Syst Bacteriol 1989 Oct;39(4):297-405).
The presence of co-existing or additional diseases with reference to an initial diagnosis or with reference to the index condition that is the subject of study. Comorbidity may affect the ability of affected individuals to function and also their survival; it may be used as a prognostic indicator for length of hospital stay, cost factors, and outcome or survival.
A spectrum of pathological conditions of impaired blood flow in the brain. They can involve vessels (ARTERIES or VEINS) in the CEREBRUM, the CEREBELLUM, and the BRAIN STEM. Major categories include INTRACRANIAL ARTERIOVENOUS MALFORMATIONS; BRAIN ISCHEMIA; CEREBRAL HEMORRHAGE; and others.
A systematic collection of factual data pertaining to health and disease in a human population within a given geographic area.
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause.
Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.
Specific practices for the prevention of disease or mental disorders in susceptible individuals or populations. These include HEALTH PROMOTION, including mental health; protective procedures, such as COMMUNICABLE DISEASE CONTROL; and monitoring and regulation of ENVIRONMENTAL POLLUTANTS. Primary prevention is to be distinguished from SECONDARY PREVENTION and TERTIARY PREVENTION.
Tumors or cancer of the ESOPHAGUS.
Contamination of the air by tobacco smoke.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
Social and economic factors that characterize the individual or group within the social structure.
Infections with organisms of the genus HELICOBACTER, particularly, in humans, HELICOBACTER PYLORI. The clinical manifestations are focused in the stomach, usually the gastric mucosa and antrum, and the upper duodenum. This infection plays a major role in the pathogenesis of type B gastritis and peptic ulcer disease.
Abnormalities in the serum levels of LIPIDS, including overproduction or deficiency. Abnormal serum lipid profiles may include high total CHOLESTEROL, high TRIGLYCERIDES, low HIGH DENSITY LIPOPROTEIN CHOLESTEROL, and elevated LOW DENSITY LIPOPROTEIN CHOLESTEROL.
An ocular disease, occurring in many forms, having as its primary characteristics an unstable or a sustained increase in the intraocular pressure which the eye cannot withstand without damage to its structure or impairment of its function. The consequences of the increased pressure may be manifested in a variety of symptoms, depending upon type and severity, such as excavation of the optic disk, hardness of the eyeball, corneal anesthesia, reduced visual acuity, seeing of colored halos around lights, disturbed dark adaptation, visual field defects, and headaches. (Dictionary of Visual Science, 4th ed)
Ongoing scrutiny of a population (general population, study population, target population, etc.), generally using methods distinguished by their practicability, uniformity, and frequently their rapidity, rather than by complete accuracy.
Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
Nonrandom association of linked genes. This is the tendency of the alleles of two separate but already linked loci to be found together more frequently than would be expected by chance alone.
Organized periodic procedures performed on large groups of people for the purpose of detecting disease.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Glucose in blood.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Former kingdom, located on Korea Peninsula between Sea of Japan and Yellow Sea on east coast of Asia. In 1948, the kingdom ceased and two independent countries were formed, divided by the 38th parallel.
Polypeptides produced by the ADIPOCYTES. They include LEPTIN; ADIPONECTIN; RESISTIN; and many cytokines of the immune system, such as TUMOR NECROSIS FACTOR-ALPHA; INTERLEUKIN-6; and COMPLEMENT FACTOR D (also known as ADIPSIN). They have potent autocrine, paracrine, and endocrine functions.
A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EMPHYSEMA.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
Falls due to slipping or tripping which may result in injury.
The transference of a kidney from one human or animal to another.
The age, developmental stage, or period of life at which a disease or the initial symptoms or manifestations of a disease appear in an individual.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
Statistical interpretation and description of a population with reference to distribution, composition, or structure.
A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
A plant genus of the family SOLANACEAE. Members contain NICOTINE and other biologically active chemicals; its dried leaves are used for SMOKING.
Formerly known as Siam, this is a Southeast Asian nation at the center of the Indochina peninsula. Bangkok is the capital city.
Degenerative changes in the RETINA usually of older adults which results in a loss of vision in the center of the visual field (the MACULA LUTEA) because of damage to the retina. It occurs in dry and wet forms.
A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)
A cluster of metabolic risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components of metabolic syndrome X include excess ABDOMINAL FAT; atherogenic DYSLIPIDEMIA; HYPERTENSION; HYPERGLYCEMIA; INSULIN RESISTANCE; a proinflammatory state; and a prothrombotic (THROMBOSIS) state. (from AHA/NHLBI/ADA Conference Proceedings, Circulation 2004; 109:551-556)
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the heart (HEART ATRIA). In such case, blood cannot be effectively pumped into the lower chambers of the heart (HEART VENTRICLES). It is caused by abnormal impulse generation.
The personal cost of acute or chronic disease. The cost to the patient may be an economic, social, or psychological cost or personal loss to self, family, or immediate community. The cost of illness may be reflected in absenteeism, productivity, response to treatment, peace of mind, or QUALITY OF LIFE. It differs from HEALTH CARE COSTS, meaning the societal cost of providing services related to the delivery of health care, rather than personal impact on individuals.
Agents that prevent clotting.
An analysis comparing the allele frequencies of all available (or a whole GENOME representative set of) polymorphic markers in unrelated patients with a specific symptom or disease condition, and those of healthy controls to identify markers associated with a specific disease or condition.
Genotypic differences observed among individuals in a population.
A constitution or condition of the body which makes the tissues react in special ways to certain extrinsic stimuli and thus tends to make the individual more than usually susceptible to certain diseases.
Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.
Physical activity which is usually regular and done with the intention of improving or maintaining PHYSICAL FITNESS or HEALTH. Contrast with PHYSICAL EXERTION which is concerned largely with the physiologic and metabolic response to energy expenditure.
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
The type species of the genus ORTHOHEPADNAVIRUS which causes human HEPATITIS B and is also apparently a causal agent in human HEPATOCELLULAR CARCINOMA. The Dane particle is an intact hepatitis virion, named after its discoverer. Non-infectious spherical and tubular particles are also seen in the serum.
The exposure to potentially harmful chemical, physical, or biological agents in the environment or to environmental factors that may include ionizing radiation, pathogenic organisms, or toxic chemicals.
Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.
The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).
An individual in which both alleles at a given locus are identical.
Individuals whose ancestral origins are in the continent of Africa.
Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
Either of the two principal arteries on both sides of the neck that supply blood to the head and neck; each divides into two branches, the internal carotid artery and the external carotid artery.
Persons living in the United States having origins in any of the black groups of Africa.
The inhabitants of rural areas or of small towns classified as rural.
Discontinuation of the habit of smoking, the inhaling and exhaling of tobacco smoke.
A family of small, non-enveloped DNA viruses infecting birds and most mammals, especially humans. They are grouped into multiple genera, but the viruses are highly host-species specific and tissue-restricted. They are commonly divided into hundreds of papillomavirus "types", each with specific gene function and gene control regions, despite sequence homology. Human papillomaviruses are found in the genera ALPHAPAPILLOMAVIRUS; BETAPAPILLOMAVIRUS; GAMMAPAPILLOMAVIRUS; and MUPAPILLOMAVIRUS.
The status of health in urban populations.
Pathological processes of the KIDNEY or its component tissues.
Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.
Tumors or cancer of the MOUTH.
Substances that lower the levels of certain LIPIDS in the BLOOD. They are used to treat HYPERLIPIDEMIAS.
The formation or presence of a blood clot (THROMBUS) within a vein.
The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.
Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.
NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
The inhabitants of a city or town, including metropolitan areas and suburban areas.
The capital is Seoul. The country, established September 9, 1948, is located on the southern part of the Korean Peninsula. Its northern border is shared with the Democratic People's Republic of Korea.
INFLAMMATION of the LIVER in humans caused by HEPATITIS B VIRUS lasting six months or more. It is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact.
Specialized connective tissue composed of fat cells (ADIPOCYTES). It is the site of stored FATS, usually in the form of TRIGLYCERIDES. In mammals, there are two types of adipose tissue, the WHITE FAT and the BROWN FAT. Their relative distributions vary in different species with most adipose tissue being white.
A flavoprotein amine oxidoreductase that catalyzes the reversible conversion of 5-methyltetrahydrofolate to 5,10-methylenetetrahydrofolate. This enzyme was formerly classified as EC 1.1.1.171.
Formation and development of a thrombus or blood clot in the blood vessel.
Tumors or cancer of the SKIN.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Abuse, overuse, or misuse of a substance by its injection into a vein.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
Knowledge, attitudes, and associated behaviors which pertain to health-related topics such as PATHOLOGIC PROCESSES or diseases, their prevention, and treatment. This term refers to non-health workers and health workers (HEALTH PERSONNEL).
Abnormally high BLOOD GLUCOSE level.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
EPIDEMIOLOGIC STUDIES based on the detection through serological testing of characteristic change in the serum level of specific ANTIBODIES. Latent subclinical infections and carrier states can thus be detected in addition to clinically overt cases.
Molecules or ions formed by the incomplete one-electron reduction of oxygen. These reactive oxygen intermediates include SINGLET OXYGEN; SUPEROXIDES; PEROXIDES; HYDROXYL RADICAL; and HYPOCHLOROUS ACID. They contribute to the microbicidal activity of PHAGOCYTES, regulation of signal transduction and gene expression, and the oxidative damage to NUCLEIC ACIDS; PROTEINS; and LIPIDS.
An individual having different alleles at one or more loci regarding a specific character.
Products in capsule, tablet or liquid form that provide dietary ingredients, and that are intended to be taken by mouth to increase the intake of nutrients. Dietary supplements can include macronutrients, such as proteins, carbohydrates, and fats; and/or MICRONUTRIENTS, such as VITAMINS; MINERALS; and PHYTOCHEMICALS.
A class of lipoproteins of small size (18-25 nm) and light (1.019-1.063 g/ml) particles with a core composed mainly of CHOLESTEROL ESTERS and smaller amounts of TRIGLYCERIDES. The surface monolayer consists mostly of PHOSPHOLIPIDS, a single copy of APOLIPOPROTEIN B-100, and free cholesterol molecules. The main LDL function is to transport cholesterol and cholesterol esters to extrahepatic tissues.
The pressure of the fluids in the eye.
The period following a surgical operation.
The co-inheritance of two or more non-allelic GENES due to their being located more or less closely on the same CHROMOSOME.
Neoplasms of the skin and mucous membranes caused by papillomaviruses. They are usually benign but some have a high risk for malignant progression.
Physiological processes in biosynthesis (anabolism) and degradation (catabolism) of LIPIDS.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
Tumors or cancer of the UTERINE CERVIX.
Major CASE Risk Factors[edit]. Some of the most significant risk factors for organizations adopting CASE technology include: * ... Another major thread emerged as a logical extension to the data dictionary of a database. By extending the range of metadata ... for training or if the first project attempted with the new technology is itself highly mission critical and fraught with risk. ...
Risk factors. Family history, major life changes, certain medications, chronic health problems, substance abuse[1][3]. ... Major depressive episode. Main article: Major depressive episode. A major depressive episode is characterized by the presence ... In 2018, a genome-wide association study discovered 44 variants in the genome linked to risk for major depression.[52] This was ... Brook DW, Brook JS, Zhang C, Cohen P, Whiteman M (November 2002). "Drug use and the risk of major depressive disorder, alcohol ...
and given a major upgrade - the first upgrade in almost a year. In summer of 2018, Fleksy opens a seed crowdfunding campaign on ... Capital At Risk". Crowdcube. Retrieved 2019-06-11. "Fleksy's keyboard grabs $800k+ via equity crowdfunding". TechCrunch. 2018- ... "Fleksy gets major robot under ThingThing". TechCrunch. 2017-07-25. "Fleksy Keyboard is raising £230,000 investment on Crowdcube ...
... the Storm Prediction Center upgraded locations within the moderate risk area to a high risk of severe weather around 4:00 p.m. ... "President Declares Major Disaster for Oklahoma". Federal Emergency Management Agency. May 4, 1999. Archived from the original ... See Brooks, Harold E.; Doswell III; Charles A. (2001). "Normalized Damage from Major Tornadoes in the United States: 1890-1999 ... "The 1999 Oklahoma Tornado Outbreak: 10-Year Retrospective" (PDF). Risk Management Solutions. 2009. Retrieved October 2, 2010. " ...
Major infectious diseases[edit]. degree of risk: high. food or waterborne diseases: bacterial diarrhea, hepatitis A, and ...
Majors, Harry M. (1975). Exploring Washington. Van Winkle Publishing Co. p. 70. ISBN 978-0-918664-00-6. WISDOM OF ELDER BOB, ... BATHE AT OWN RISK. Boulder Lake (Washington) Boulder Peak (Washington) Robert L. Woods, Olympic Mountains Trail Guide. Seattle: ...
Major: lenalidomide-risk of thrombosis. *Moderate: cyclosporine-risk of high blood pressure may be greater in combination with ... but increases the risk of retinopathy. Due to the limited clinical benefit and increased risk of retinopathy, early or late ... The FDA has focused its concern on study results from some clinical trials showing an increased risk of death and tumor growth ... In a revised black box warning, the FDA notes significant risks, advising that ESAs should be used only in patients with cancer ...
Major infectious diseases[edit]. Degree of risk: high *Food or waterborne diseases: bacterial and protozoal diarrhea, hepatitis ... Note: WH5N1 avian influenza has been identified in this country; it poses a negligible risk as of 2009.[citation needed] ... Children at risk of contracting HIV/AIDS in Afghanistan Archived 2010-12-30 at the Wayback Machine.. December 1, 2008. ...
Major infectious diseases[edit]. Degree of risk: high. Food or waterborne diseases: bacterial and protozoal diarrhea, hepatitis ... Major ethnic. Bengali. Minor ethnic. Chakma,. Marma,. Mundas,. Garos (Achiks),. Oraons,. Santhals,. Mro,. Manipuri,. Zomi, ... Population trends for major religious groups in Bangladesh (1951-2011). Religions of Bangladesh (2013)[19]. ... 2005), Mitochondrial DNA haplogroup K is associated with a lower risk of Parkinson's disease in Italians, European Journal of ...
As Turner Field, the stadium hosted notable events such as games 1 and 2 of the 1999 World Series and the 2000 Major League ... Klepal, Dan (May 20, 2014). "Braves: We're Assuming Ultimate Risk". The Atlanta Journal-Constitution. Retrieved May 20, 2014. ... The stadium hosted the Atlanta Braves of Major League Baseball from 1997 to 2016, following a multimillion-dollar renovation to ... Bowman, Mark (November 11, 2013). "Braves leaving Turner Field for Cobb County". Major League Baseball Advanced Media. ...
"Earthquake risk zones » Seismic Resilience". www.seismicresilience.org.nz. Retrieved 2018-12-09. "Major changes to earthquake ... with the eastern North Island and western South Island having the highest risk. After the 2011 Christchurch earthquake a major ... A substantial 86.1% of people living in New Zealand live either in or around a major city. "'Unliveable': Five townhouses less ... Many old office-blocks and church-buildings have been converted to apartments in New Zealand's major centres. Small, often very ...
As noted above, drilling cost is a major component of a geothermal power plant's budget and is one of the key barriers to wider ... Drilling accounts for over half the costs, and exploration of deep resources entails significant risks. A typical well doublet ... "Major Companies". Geothermal Energy Association. Archived from the original on 22 April 2014. Retrieved 24 April 2014. Deloitte ... Each phase has associated risks. At the early stages of reconnaissance and geophysical surveys, many projects are canceled, ...
About half are the result of major trauma and about half occur as a result of minor trauma. Major trauma may include mechanisms ... Risk factors include obesity. The condition may also occur in a number of genetic disorders such as Ellis-van Creveld syndrome ... About half of cases are the result of major trauma and about half occur as a result of minor trauma. In about half of cases the ... Cases due to major trauma often have other injuries. Minor trauma may include tripping while walking or while playing sports. ...
Woodall, Louie (2018-10-03). "Goldman Sachs is last major bank holding CDO squared". Risk Quantum. v t e. ...
Escorting and securing dangerous prisoners in high risk situations; Providing operational support for major law enforcement ... responding in their state or territory to high-risk incidents such as sieges or executing high-risk search warrants, which are ... Undertaking searches of premises in high risk situations (high risk search warrants); Suicide intervention/rescue; The arrest ... Each State and Territory maintain a PTG able to respond and resolve high-risk incidents across their jurisdiction, and inter- ...
I'll miss my team': Rolet's parting words - Risk.net". Risk.net. 29 November 2017. Retrieved 21 February 2018. "How much of a ... "London Stock Exchange launches major interest rate derivatives venture". FinTech Futures. Retrieved 11 October 2018. "European ... "Lifetime achievement award: Xavier Rolet - Risk.net". Risk.net. 8 December 2017. Retrieved 27 December 2017. "Editorial: The ... After that, Rolet worked at Dresdner Kleinwort Benson from 1997-2000 as Global Head of Risk and Trading. He then worked at ...
Ronald K. Kendall; Ernest Smith; Leslie B. Smith, Major, USAF, BSC; Roger L. Gibson, Lieutenant Colonel, USAF (August 2001). " ... increasing the risk of exposure. JP-8 exposure has also been linked to hearing problems, but rather than being unable to hear ... "JP-8 Final Risk Assessment" (PDF). Texas Tech University. Archived (PDF) from the original on March 27, 2020. Retrieved April ...
IF RISK: Do you think that would be a major risk; or a risk, but not major? (Results by all adults) However, although Americans ... In late April 2017, Trump stated that "[t]here is a chance that we [the United States] could end up having a major, major ... "Trump fears 'major, major conflict' with North Korea". BBC. April 28, 2017. Retrieved April 28, 2017. Torbati, Yeganeh; Lee, Se ... "The Risk of Nuclear War with North Korea". The New Yorker. Retrieved December 11, 2020. "U.S. Relations With the Republic of ...
Tap water is believed[by whom?] to be the major reservoir associated with human disease. Biosafety level 2 is indicated. First ... Patients with silicosis are at risk. It also appears in patients with hairy cell leukemia, but not in other lymphoproliferative ...
Smoking is a major risk factor. Treatment of gingivitis is dependent on how severe and how far the disease has progressed. If ... One of the major goals in the treatment of patients with cleft is to enhance social acceptance by surgical reconstruction. A ... Other risk factors are dentures and tongue piercing. The typical signs are a white patch that may be associated with burning, ... social and psychological history as well as assessing certain lifestyle risk factors that may be involved in disease processes ...
The major parts of the Space Flight Tracking and Data Network (STDN) are: the NASA Integrated Services Network (NISN), network ... ". "Generation to Generation, A Lower Risk". Archived from the original on June 29, 2011. Retrieved December 22, 2010. "NASA ... Susan Hendrix (July 22, 2009). "NASA Tracking and Data Relay Satellite Mission Passes Major Review ...
"Venous thromboembolism - reducing the risk". Guidance.nice.org.uk. 2013-11-07. Retrieved 2014-01-16. CS1 maint: discouraged ... "Management of bleeding following major trauma: an updated European guideline". She was a member of the National Institute for ... campaigns to raise awareness of thrombosis-in particular the risk of hospital-acquired deep vein thrombosis by mandating risk ... "Management of bleeding following major trauma: an updated European guideline". Crit Care. 14 (2): R52. doi:10.1186/cc8943. PMC ...
They may analyze risk. Many engineers use computers to produce and analyze designs, to simulate and test how a machine, ... Numerous specialties are recognized by professional societies, and each of the major branches of engineering has numerous ... Baecher, G.B.; Pate, E.M.; de Neufville, R. (1979). "Risk of dam failure in benefit/cost analysis". Water Resources Research. ... Hartford, D.N.D. and Baecher, G.B. (2004) Risk and Uncertainty in Dam Safety. Thomas Telford International Commission on Large ...
Office of U.S. Foreign Disaster Assistance (August 1993). Significant Data on Major Disasters Worldwide 1900-present (PDF) ( ... Christope Buffet (July 2011). "Disaster Risk Reduction in Madagascar" (PDF). DDR Madagascar. Solidarité et changement ...
Risk factors[edit]. Acquired[edit]. *Older age[5]. *Major surgery and orthopedic surgery[6] ... Evidence supports the use of heparin in people following surgery who have a high risk of thrombosis to reduce the risk of DVTs ... In adults who have had their lower leg casted or placed in a brace for more than a week, LMWH decreased the risk of VTEs.[31] ... Goldhaber, Samuel Z. (2010). "Risk Factors for Venous Thromboembolism". Journal of the American College of Cardiology. 56 (1): ...
Major experiments[edit]. Examples of some of the experiments and investigations on the mission.[5] ... 1 payload for ISS Risk Mitigation. *18 payloads NASA's Office of Biological and Physical Research (OBPR) with 23 investigations ...
In an interview with Gary T. Schwartz of the Rutgers Law Review, Copp asserted that he was also a major source of the ... In the memo Ford estimated the cost of fuel system modifications to reduce fire risks in rollover events to be $11 per car ... In an interview with Schwartz, Copp asserted that he was also a major source of the information for the Mother Jones story, ... Unlike most 1970s cars, the addition of larger bumpers to the Pinto did not necessitate major changes to the bodywork. While ...
Martel, Bernard; Cassidy, Keith (2004-07-01). "Rubidium". Chemical risk analysis: a practical handbook. p. 215. ISBN 978-1- ... "Rubidium chloride in the treatment of major depression". Minerva Psichiatrica. 34 (2): 101-110. PMID 8412574. "Rubidium 276332 ...
"The Hindu Business Line : Minor ports, major trouble". Chandnani, Lajpat Ray. General Insurance, Reinsurance and Risk ... The distinction between major and minor ports is not based on the amount of cargo handled. The major ports are managed by port ... Walking has constituted a major form of transport in ancient times.This mode of transport has always been a first foot for ... The operations of the major airports in India have been privatised over the past five years and this has resulted in better ...
Other major roads in Darwin include, Tiger Brennan Drive, Amy Johnson Avenue, Dick Ward Drive, Bagot Road, Trower Road, and ... They had covered the last 300 miles [480 km] over water on one motor, risked death landing on a field made soggy by the first ... There is one major private hospital, Darwin Private Hospital, in Tiwi, adjacent to the Royal Darwin Hospital. Darwin Private ... There have been no major films set in Darwin; however, some scenes for Australia by Baz Luhrmann and Black Water were both shot ...
... a very practical problem accessing fetal DNA without creating a major health risk for the unborn child."[3] In December 2015, ... The district court said: "[T]he claims at issue pose a substantial risk of preempting the natural phenomenon of paternally ... Yet, "undue preemption" remains a major concern-"the fear that others' innovative future applications of the law will be ... that created risks of miscarriage). Then they realized that they could selectively amplify the fetal DNA by focusing on the ...
Most surgeons will not intervene until after the age of six months due to the heightened risk which blood loss poses before ... "Valproic acid monotherapy in pregnancy and major congenital malformations". The New England Journal of Medicine. 362 (23): 2185 ... The main risks of prolonged elevated intracranial pressure may include cognitive impairment and impaired vision through ... Medical history should in any case include questions about risk factors during pregnancy, the familial rate and the presence of ...
Major code sectionsEdit. Table 2. Major U.S. Code Sections of the Federal Insecticide, Fungicide, and Rodenticide Act (codified ... sound science is used to assess risk to the listed species. *there is an attempt at finding means to avoid concerns of listed ... Congress enacted major revisions to FIFRA in 1972 with the Federal Environmental Pesticide Control Act (FEPCA).[1] The 1947 law ... Note: This table shows only the major code sections. For more detail and to determine when a section was added, the reader ...
Major highways serving the city include State Highway 146 and Interstate 10. As of 2010, Baytown had a population of 71,802,[6] ... which reduces the risk of an earthquake.[14] The one significant earthquake that has been reported in the area was the result ... Exxon-Mobil is still one of the major employers in the city and now runs over 10 plants in the area including a newly announced ... Glenn Wilson, former Major League Baseball outfielder. *Renée Zellweger, Oscar-winning actress, resident until age 9. Lived in ...
... increases the risk of developing diabetes by 1.5 times and is the greatest risk of the common genetic variants.[13] Most of the ... No major organization recommends universal screening for diabetes as there is no evidence that such a program improve outcomes. ... while medication does not reduce risk after withdrawal.[80] While low vitamin D levels are associated with an increased risk of ... with saturated fats and trans fatty acids increasing the risk, and polyunsaturated and monounsaturated fat decreasing the risk. ...
One of the risks of LNG is a rapid phase transition explosion (RPT), which occurs when cold LNG comes into contact with water.[ ... There was a major push in the mid to late nineteenth century to liquefy all gases. A number of scientists including Michael ... "LNG: Benefits and Risks of Liquified Natural Gas". Archived from the original on 2013-08-08. Retrieved 2013-02-25.. ... Major international oil companies (IOCs) such as ExxonMobil, Royal Dutch Shell, BP, Chevron, Total and national oil companies ( ...
A major reason for this fast approval was the presentation Merck gave to the committee with results from Study 035 (see below ... Furthermore, it is no longer recommended to use in the United States for initial treatments due to pill burden and risk of ...
7 Risks and problems *7.1 Negative outcomes *7.1.1 Adequacy of regulation and CAM safety ... has created a classification system for branches of complementary and alternative medicine that divides them into five major ... Even low-risk medications such as antibiotics can have potential to cause life-threatening anaphylactic reactions in a very few ... Risks and problems. Negative outcomes. See also: List of herbs with known adverse effects ...
... initiated a series of major irrigation projects across the country.[269] In the Eastern Zone, for instance, a huge dam ... Khmer troops deserted the French Army in large numbers and the French government relented, rather than risk a costly, ... In summer 1973, the Khmer Rouge launched its first major assault on Phnom Penh, but was forced back amid heavy losses.[193] ... the Vietnamese Army launched a major offensive, overrunning the Khmer Rouge's Cambodian basis and pushing Pol Pot back into ...
It seems that HMB is able to act on three of the four major mechanisms involved in muscle deconditioning (protein turnover, ... It is currently recommended that patients at risk of or suffering from sarcopenia consume a diet high in protein, engage in ... It seems that HMB is able to act on three of the four major mechanisms involved in muscle deconditioning (protein turnover, ... Muscular atrophy decreases qualities of life as the sufferer becomes unable to perform certain tasks or worsen the risks of ...
The department is designed as a regional perinatal center for high risk pregnancies. The 56-bed Neonatal Intensive Care Unit ... is a 577-bed non-profit major teaching hospital located in Livingston, New Jersey. It is the oldest and largest nonprofit, ... 2009 Major Organ Transplant Centers Announce New Coalition, Medscape Medical News, January 14, 2000 - accessed July 11, 2009 ... hospital in the United States by AARP Modern Maturity Magazine for quality of care for adults at acute care hospitals in major ...
Invasins, such as pneumolysin, an antiphagocytic capsule, various adhesins, and immunogenic cell wall components are all major ... risk factors, susceptibility patterns and antimicrobial management". The Pediatric Infectious Disease Journal. 14 (9): 751-9. ... pneumoniae was recognized as a major cause of pneumonia in the late 19th century, and is the subject of many humoral immunity ...
It's nearly as important as a major election - Dion will be the new Leader of the Opposition and will be the main challenger of ... Should the headline mention that the giant "iceberg" poses a serious risk to oil platforms in its drift path ? (from CBC ... Despite the magnitude of the quake, this doesn't seem to be a major disaster afterall. --PFHLai 17:33, 27 December 2006 (UTC) ... Could you elaborate a little bit and explain why this is major international news, please ? Not everyone (okay, not me, at ...
The changes have been considered an attempt to build a consensus among major Galician philology trends and represent, in the ... grammar has established that the exclamation and question marks will appear only at the end of the sentence if there is no risk ... Language unification would also have the benefit of linking the Galician language to another major language with its own ... argue that they have become separate languages due to major differences in phonetics and vocabulary usage, and, to a lesser ...
... where the risk to the patient from lack of knowledge about disease progress is much greater than the risk from the test ... Two major sources of noise in PET are scatter (a detected pair of photons, at least one of which was deflected from its ... FDG-PET imaging of atherosclerosis to detect patients at risk of stroke is also feasible and can help test the efficacy of ... Since the tracers are radioactive, the elderly and pregnant are unable to use it due to risks posed by radiation. ...
De Swert LF (1999). "Risk factors for allergy". Eur. J. Pediatr. 158 (2): 89-94. doi:10.1007/s004310051024. PMID 10048601. ... and failure to meet major responsibilities at work, school, or home. Depending on the level of severity, this disorder is ... Moreover, there is increasing evidence that, despite a range of genetic risks for addiction across the population, exposure to ... This process may increase the risk for relapse in addicts attempting to quit.[12] ...
The major veins reach to the margin of the leaf.. Camptodromous. Major veins extend close to the margin, but bend before they ... Optical masking of chlorophyll by anthocyanins reduces risk of photo-oxidative damage to leaf cells as they senesce, which ... All major veins diverge towards the tip. e.g. Gossypium, Cucurbita, Carica papaya, Ricinus communis. Ternately (ternate-netted) ... Major veins diverge from origin at base then converge towards the tip. e.g. Zizyphus, Smilax, Cinnamomum. Multicostate ...
EVD has a risk of death in those infected of between 25% and 90%.[1][139] As of September 2014[update], the average risk of ... The second major outbreak occurred in Zaire (now the Democratic Republic of the Congo, DRC), in 1995, affecting 315 and killing ... Health-care workers treating people with Ebola are at greatest risk of infection.[59] The risk increases when they do not have ... The CDC recommends monitoring for the symptoms of Ebola disease for those both at "low risk" and at higher risk.[123] ...
One of the major complications of this treatment is progression of Nelson's syndrome which is caused by enhance level of tumor ... reoperation has lower success rate and increases the risk of pituitary insufficiency.[14] ... The prevalence of hypertension, and abnormalities in glucose metabolism are major predictors of mortality and morbidity in ...
The authors show how a major part of the body of literature that used these approaches seem to have mistaken and interpreted ...
The states pay a monthly capitated rate per member to the MCOs that provide comprehensive care and accept the risk of managing ... Medicaid funding has become a major budgetary issue for many states over the last few years, with states, on average, spending ... The major concern is that this rule will create a disincentive for low-income people to seek healthcare. It is possible that ... or military connection are eligible for the full range of major federal means-tested benefit programs, including Medicaid (Medi ...
Four major glacial events have been identified, as well as many minor intervening events. A major event is a general glacial ... which allowed them a more nutritious diet and a decreased risk of famine.[21][23][67] Many of the famines experienced by ... The formation of the isthmus had major consequences on global temperatures, because warm equatorial ocean currents were cut off ...
A systematic review of observational studies concluded that such exposure does not appear to increase the risk of major birth ... Pregnancy category refers to an evaluation of a substance's risk of injury to a fetus if used by the mother during pregnancy.[ ... Risk factors for the development of acne, other than genetics, have not been conclusively identified. Possible secondary ... the high risk of birth defects with 5α-reductase inhibitors limits their use in women.[1][138] However, 5α-reductase inhibitors ...
... mechanisms of action; the three major independent mechanisms are (1) antibody dependent cellular cytotoxicity (ADCC ... carries with it the risk of infection.[citation needed] ...
Potential risk factors[edit]. Temperature and heat exposure[edit]. The temperature and heat levels of the body are directly ... Because they are not regeneratable in humans, any major damage or loss of these hair cells leads to permanent hearing ... Common groups at risk of becoming victim to this phenomenon include avid listeners of music and others who listen or work with ... Melnick, W. (1991). HUMAN TEMPORARY THRESHOLD SHIFT (TTS) AND DAMAGE RISK. [Article]. Journal of the Acoustical Society of ...
... it has been noted that co-operation on such a major defence project would be high risk due to Japan's lack of previous arms ... "Abbott's plunge into submarine market is a risk we cannot afford". The Age. Retrieved 14 May 2016.. ... There were four possible routes for the SEA 1000 project to take, in order of increasing design complexity and risk: *Buy a ... Scott, Richard (14 January 2010). "Horns of a dilemma: Project SEA 1000 seeks to balance technology and risk". International ...
Major causes of PEM in Nepal is low birth weight of below 2.5 kg, due to poor maternal nutrition, inadequate dietary intake, ... Millions of people are at risk of infection and thousands die every year due to communicable diseases, malnutrition and other ... The major causes of neonatal death in Nepal are infection, birth asphyxia, preterm birth, and hypothermia. Given Nepal's ... "A case control study on risk factors associated with malnutrition in Dolpa district of Nepal". Retrieved 2016-09-11. Policy - ...
Intense states of distress and unease increase the risk of suicide, as well as being unpleasant in themselves. Relieving ... Major depressive disorder (unipolar) and dysthymia. *Bipolar disorder[4] and cyclothymia. *Borderline personality disorder[5] ...
Risks to donor[edit]. The risks of a complication depend on patient characteristics, health care providers and the apheresis ... Major complications are veno-occlusive disease, mucositis, infections (sepsis), graft-versus-host disease and the development ... increase the risk of graft rejection. A mismatch of an HLA Type II gene (i.e. HLA-DR, or HLA-DQB1) increases the risk of graft- ... Drug risks[edit]. Filgrastim is typically dosed in the 10 microgram/kg level for 4-5 days during the harvesting of stem cells. ...
Brief report:predictors of heavy internet use and associations with health promoting and health risk behaviors among Hong Kong ... The invention of polished stone axes was a major advance that allowed forest clearance on a large scale to create farms. This ... Brief report:predictorsofheavyinternetuseandassociationswithhealthpromoting and health risk behaviors among Hong Kong ... written by the Unabomber Ted Kaczynski and printed in several major newspapers (and later books) as part of an effort to end ...
The highest risk of all was seen in people who lived in an urban environment, close to a major road, and had lived there for a ... "It shows a very straightforward result - the closer you live to a major highway the higher your risk of dementia. ... Cite this: Dementia Risk Rises With Proximity to Major Roads - Medscape - Jan 05, 2017. ... showed a clear dose response in that the risk for dementia increased with the proximity to a major road, with a 7% increased ...
Major surgery doubles the chance of experiencing a substantial decline in mental skills, such as reasoning, memory and language ... Major surgery was also found to age the brain by an average of four months and three days Credit: Getty ... Human organs can be stored for three times as long in major breakthrough for transplants ... E-cigarette cancer warning as new study finds mint and menthol flavour risk ...
Major Work-Related Risk Factors. CLOSE ALL. What are factors that can lead to injuries in an office job?. Basic office ... This combination increases the risk for RMIs. A person may be able to set his or her work pace and adapt to the stresses that ... Work-related factors that present the greatest risk for MSIs involve: *fixed and constrained postures that are frequently ... significantly accelerates the risk for developing RMIs. ...
A Major Hazard Risk Assessment (MHRA) was developed in Australia after a series of mine disasters in the 1990s. A MHRA is used ... Mining Publication: Using Major Hazard Risk Assessment to Appraise and Manage Escapeway Instability Issues: A Case Study. ... Major Hazard Risk Assessment Applied to Pillar Recovery Operations. *Mapping Hazards with Microseismic Technology to Anticipate ... A MHRA is a structured process that identifies the characteristics of major hazards, assesses and ranks the risk they present, ...
Being overweight is a major risk for people infected with the new coronavirus and the United States is particularly vulnerable ... PARIS (Reuters) - Being overweight is a major risk for people infected with the new coronavirus and the United States is ... said as many as 17 million of Frances 67 million citizens were seriously at risk from the coronavirus because of age, pre- ...
One technique recently studied by NIOSH, Major Hazard Risk Assessment (MHRA), may help mine operators to mitigate the risks ... Major Hazard Risk Assessment Applied to Pillar Recovery Operations. Keywords: Hazard recognition Retreat mining Risk analysis ... Using Major Hazard Risk Assessment to Appraise and Manage Escapeway Instability Issues: A Case Study ... Defining Risk Perception and Tolerance Within a Decision Science Framework. *Focus on Prevention: Conducting a Fire Risk ...
... that eating a high-fiber diet is associated with lower mortality risk from serious chronic diseases. ... that eating a high-fiber diet is associated with lower mortality risk from serious chronic diseases. ... their risk of dying from it drops below the risk of those who dont eat a lot of fiber ... In addition, those patients also had a 14 percent lower risk of dying from any cause when compared to those who reported the ...
A study published Thursday in Science has found that a health care risk-prediction algorithm, a major example of tools used on ... Racial Bias Found in a Major Health Care Risk Algorithm. Black patients lose out on critical care when systems equate health ... When contacted about these results, eight of the top U.S. health insurance companies, as well as two major hospitals and the ... For example, among all patients classified as very high-risk, black individuals turned out to have 26.3 percent more chronic ...
A new study has discovered that a genetic predisposition for major depression also increases an individuals risk for a suicide ... Genetic Liability for Major Depression Ups Risk of Suicide Attempts. By Rick Nauert PhD Associate News Editor ... A new study has discovered that a genetic predisposition for major depression also increases an individuals risk for a suicide ... Nauert PhD, R. (2019). Genetic Liability for Major Depression Ups Risk of Suicide Attempts. Psych Central. Retrieved on July 15 ...
... Hide Slideshow Introduction Read Slideshow ... Decision-makers and key users are discovering the benefits and synergies that exist between policy, risk and compliance ... Decision-makers and key users are discovering the benefits and synergies that exist between policy, risk and compliance ... more risk-aware, and compliant. We will also continue to see a strong focus on bringing together the right teams of people and ...
... Major Trends Shaping Governance, Risk Management, and ... more risk-aware, and compliant. We will also continue to see a strong focus on bringing together the right teams of people and ... take a closer look at the major trends expected in 2015. ... Risk, and Compliance. Five Tips to Prepare Your Business for ...
... heart disease and other major health problems. As the government addresses these disparities, African American health advocates ... Black Women at Higher Risk for Major Diseases. By: Molly M. Ginty , February 25, 2005. LikeTweet EmailPrint More * More on ... womensenews.org/2005/02/black-women-at-higher-risk-major-diseases/) ... Cole says this-combined with the challenge of dealing with racism-can boost stress levels that increase black womens risk of ...
... discusses the major management challenges and program risks facing the Social... ... Major Management Challenges and Program Risks: Social Security Administration GAO-01-261 Published: Jan 01, 2001. Publicly ... Major Management Challenges and Program Risks: Department of Health and Human Services GAO-01-247, Jan 1, 2001 ... Major Management Challenges and Program Risks: Department of Housing and Urban Development GAO-01-248, Jan 1, 2001 ...
GAO provided information on the major management challenges and program risks facing the... ... Major Management Challenges and Program Risks: Department of Agriculture OCG-99-2 Published: Jan 01, 1999. Publicly Released: ... Major Management Challenges and Risks: Department of Health and Human Services OCG-99-7, Jan 1, 1999 ... Major Management Challenges and Risks: Department of Housing and Urban Development OCG-99-8, Jan 1, 1999 ...
... gb-gplus-shareMajor management challenges and program risks : Small Business Administration. ... 0 ReviewsWrite reviewhttps://books.google.com/books/about/Major_management_challenges_and_program.html?id=G1F2KiwRjxUC ... books.google.comhttps://books.google.com/books/about/Major_management_challenges_and_program.html?id=G1F2KiwRjxUC&q=loan+ ...
The prospect of a global tit-for-tat poses major disruption risks for auto manufacturers across several fronts. ... Escalating trade wars look set to be the new risk frontier in auto supply disruption. With countries and trading blocs around ... The length and complexity of global supply chains and the nature of component manufacturing make trade wars a major concern. ... Trade barriers have the potential to alter the risk landscape considerably as far as supply chain disruption is concerned. Last ...
... Updated: Jun 06, 2019 ... encoded search term (How does thrombolytic therapy affect risk of major bleeding in pulmonary embolism (PE)?) and How does ... Thrombolysis for pulmonary embolism and risk of all-cause mortality, major bleeding, and intracranial hemorrhage: a meta- ... 83] Thrombolytic therapy was associated with a greater risk of intracranial hemorrhage and a lower risk of recurrent pulmonary ...
Obesity a major factor in risk of hospitalisation and death from COVID - study. 29 April 2021, 11:41 am. ... Obesity is a significant factor in the likelihood that someone will be severely affected by COVID-19, a major UK study has ... her reign as a daytime TV anchor was a major milestone for representation. Photograph: Andrew Harnik/AP ...
People who live close to high-traffic roadways face a higher risk of developing dementia than those who live further away, new ... The increase in the risk of developing dementia went down to four per cent if people lived 50-100 metres from major traffic, ... At over 200 metres, there was no elevated risk of dementia. * There was no correlation between major traffic proximity and ... Living near Major Traffic Linked to Higher Dementia Risk (IMAGE) view more ...
... is the largest study to-date of genetic risk factors for major depression. ... identifying 44 genetic variants which are risk factors for depression, 30 of which are newly discovered. The study, by the ... A global research project has mapped out the genetic basis of major depression, ... A global research project has mapped out the genetic basis of major depression, identifying 44 genetic variants which are risk ...
... February 10, 2020. 0 ... Home Neuroscience Major Depressive Disorder Study Identifies Promising Biomarker for High Risk Individuals ... Studies by Kuniaki Saito, PhD, Yasuko Yamamoto, PhD, and colleagues found individuals who were at high risk of major depressive ... The results were similar to those recorded for patients who were at risk of major depressive disorder. ...
Empirical results from major league baseball using a binary choice probit model, which corrects for sample selection bias, ... In such cases, a long-term contract may be observed without a risk premium paid by the worker. The labor markets of ... Examination of contract length among major league baseball players shows that long-term contracts for marginal players, those ... have an incentive to reallocate risk with long-term labor contracts. ...
Without changes, the pipeline could be at risk of rupturing. ... Feds Say Major New York Gas Pipeline Poses Safety Risk. A ... A major natural gas pipeline stretching across southern New York may be at risk of rupturing and poses a safety threat, ... The number of major accidents has more or less held steady in recent years. Still, Carl Weimer, executive director of Pipeline ... The pipelines owner, Millennium Pipeline Co., has reduced pressure on the line, lessening the risk of explosion, but there are ...
PRNewswire/ -- Janus Global Operations (JGO) has been awarded a contract by a major International Oil Company (IOC) to provide ... The company has major operations in Basra and Bagdad. JGOs work in risk management and security is part of its role as an ... Janus Global Operations to provide security, risk management, in Iraq for major international oil company ... DUBAI, United Arab Emirates, July 21, 2016 /PRNewswire/ -- Janus Global Operations (JGO) has been awarded a contract by a major ...
The study found that children living within 75 meters (about 82 yards) of a major road had an almost 50 percent greater risk of ... Children living close to a major road are significantly more likely to have asthma than children who live farther away, ... "This is a potentially important public health problem because there are many children who live near major roads." ... The researchers determined how far each participating child lived from a major road: a freeway, large highway or a feeder road ...
... Sood MM, Garg AX, Bota SE, Marisiddappa L, McArthur E, Naylor KL, Kapral ... After propensity score matching, the relative risk for major hemorrhage and its subtypes attenuated but remained elevated. The ... Background - Major hemorrhagic events are associated with significant morbidity and mortality. The researchers examined the ... Conclusion - Kidney transplantation recipients have a higher risk of hospitalization with hemorrhage compared to the general ...
... identifying 44 genetic variants which are risk factors for depression, 30 of which are newly discovered. ... A global research project has mapped out the genetic basis of major depression, ... Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression, Wray et al ... A global research project has mapped out the genetic basis of major depression, identifying 44 genetic variants which are risk ...
A project tracking nearly eight million infants found that exposure to chemicals in the air drove up the risk of death by up to ... Air pollution raises babys risk of dying by 50%, major study finds. By BEN SPENCER. Sep 27, 2019 ... London - Air pollution significantly raises the risk of babies dying in their first year, a major study has found. ... Experts have long warned that air pollution poses a risk to health. But the new research, to be presented at the European ...
A new study has shown that major depression more than doubles the risk of dementia among adults with diabetes. Dementia is the ... Major depression more than doubles dementia risk in diabetic adults. March 6th, 2010 - 2:57 pm ICT by ANI Tweet. ... "Diabetes alone has shown to be a risk factor for dementia, as has major depression by itself," said the lead author of the ... Washington, March 6 (ANI): A new study has shown that major depression more than doubles the risk of dementia among adults with ...
Home › News › Consumer News › Earthquakes Put Millions of Lives, Major Cities at Risk ... Earthquakes Put Millions of Lives, Major Cities at Risk. Print this page ... Millions of people live in major cities, such as New York, Los Angeles, Tokyo, Delhi and Shanghai, that are situated on fault ... Children are often at higher risk of injury and death than are adults during earthquakes, the researchers said. The elderly are ...
  • Moreover, suicide attempters with major depressive disorder, bipolar disorder or a schizophrenia diagnosis carry a greater genetic liability for major depression than non-attempters. (psychcentral.com)
  • Specifically, the current study compared the genomes of 6,569 suicide attempters and 17,232 non-attempters with major depressive disorder, bipolar disorder, or schizophrenia from the Psychiatric Genomics Consortium, an international collaboration for conducting large-scale genetic studies of psychiatric disorders. (psychcentral.com)
  • Major depressive disorder affects over 300 million people worldwide, but so far there have been no established biomarkers that clinicians can rely on to detect early-stage depression symptoms. (genengnews.com)
  • Now, in a new study published in Scientific Reports, scientists at Fujita Health University led by Professor Yasuko Yamamoto have shown that the levels of anthranilic acid in blood may provide a basis for identifying patients at risk of major depressive disorder. (genengnews.com)
  • The results of research headed by scientists at Japan's Fujita Health University suggest that a metabolite in the kynurenine (KYN) pathway could represent a clinical biomarker for identifying individuals with depression-like symptoms who are at risk of developing major depressive disorder. (genengnews.com)
  • Studies by Kuniaki Saito, PhD, Yasuko Yamamoto, PhD, and colleagues found individuals who were at high risk of major depressive disorder (HRMDD) exhibited elevated blood levels of the KYN pathway metabolite anthranilic acid (AA), and decreased levels of tryptophan when compared with control individuals, but no changes to other metabolites. (genengnews.com)
  • Various lines of scientific evidence suggest that tryptophan metabolism is involved in the symptoms of major depressive disorder," Yamamoto noted. (genengnews.com)
  • The researchers reported their studies in Scientific Reports , in a paper titled, " Serum Metabolic Profiles of the Tryptophan-Kynurenine Pathway in the high risk subjects of major depressive disorder . (genengnews.com)
  • More than 300 million people suffered from major depressive disorder (MDD) in 2017, and the incidence is on the rise year on year, the authors wrote. (genengnews.com)
  • To test this idea, Saito's team analyzed serum samples from 61 patients who had clinical test scores that indicated a high risk of developing major depressive disorder, and from another 51 healthy control individuals. (genengnews.com)
  • Given that the kynurenine pathway uses tryptophan and produces anthranilic acid, the findings are in agreement with previous study results reporting increased kynurenine pathway activity in patients at risk of developing major depressive disorder. (genengnews.com)
  • Major depressive disorder (MDD) and loneliness are phenotypically and genetically correlated with coronary artery disease (CAD), but whether these associations are explained by pleiotropic genetic variants or shared comorbidities is unclear. (nature.com)
  • Major depressive disorder (MDD) is among the most common mental disorders, with a lifetime prevalence as high as 17% [ 1 ]. (nature.com)
  • Therefore, ammonia metabolism genes may link a range of diseases involving glutamate signaling such as Alzheimer's disease (AD), major depressive disorder (MDD), and type 2 diabetes (T2D). (springer.com)
  • We aimed to estimate mortality rates of psychological distress and major depressive disorder (MDD) compared to a referent group with no MDD or psychological distress. (ices.on.ca)
  • 7-9 Major depressive disorder (MDD) may be of particular interest because it is much more common than schizophrenia and is treated with a broad range of psychotropics. (psychiatrictimes.com)
  • The central goal of this statement is to position major depressive disorder (MDD) and bipolar disorder (BD) alongside other pediatric diseases previously identified as moderate risk for cardiovascular disease (CVD)," the authors stated in their conclusion. (medicaldaily.com)
  • Major Depressive Disorder and Bipolar Disorder Predispose Youth to Accelerated Atherosclerosis and Early Cardiovascular Disease. (medicaldaily.com)
  • Functional magnetic resonance imaging (fMRI) could be used to predict which patients with recovered major depressive disorder are most likely to have more depressive episodes, according to a study published in JAMA Psychiatry . (neurosciencenews.com)
  • Researchers from King's College London and The University of Manchester, funded by the MRC, gave 64 patients who were in remission from major depressive disorder, and not on prescribed medication, fMRI scans to look for atypical connections in the brain. (neurosciencenews.com)
  • The researchers also tested the approach on a control group of 39 people with no personal or family history of major depressive disorder, finding that they also did not have the increased interconnectedness. (neurosciencenews.com)
  • According to the U.S. National Institute for Diabetes and Digestive and Kidney Diseases , health risks associated with obesity include type 2 diabetes, high blood pressure, heart disease, stroke, sleep apnea, fatty liver disease, osteoarthritis, gallbladder disease and more. (newswise.com)
  • NEW YORK (GenomeWeb) - An international team of researchers has developed a genetic risk score that significantly improves the ability of clinicians to predict future major coronary artery disease events (MCE) in type 2 diabetes patients. (genomeweb.com)
  • In a scientific paper published today a team of scientists from deCODE genetics (Nasdaq:DCGN) and colleagues report the discovery of a variant in a gene on chromosome 10 that represents the most significant genetic risk factor for type 2 diabetes (T2D) found to date. (decode.com)
  • The incidence of type 2 diabetes is increasing rapidly in the industrialized world, in part due to the increase in obesity, one of the major risk factors for developing the disease. (decode.com)
  • New research presented at this year's annual meeting of the European Association for the Study of Diabetes (EASD), held online this year (21-25 September), shows that having type 1 diabetes (T1D) is associated with a 33% increase in the risk of falls compared with the general population, while having type 2 diabetes (T2D) is associated with a 19% increased risk of falls. (sciencecodex.com)
  • The authors say: "While of course we cannot do anything about getting older or our gender, diabetes - especially type 2 diabetes - use of medications and alcohol abuse could be potentially modifiable risk factors for falls. (sciencecodex.com)
  • Now that we've seen these remarkable results, a well-designed randomized controlled trial is needed to definitively determine whether metabolic surgery can reduce the incidence of major heart problems in patients with type 2 diabetes and obesity. (diabetes.co.uk)
  • Sub out the soda and white bread to reduce type 2 diabetes risk. (medicaldaily.com)
  • Study after study has shown that excessive consumption of highly processed carbs and sugar can put a person at risk of developing type 2 diabetes. (medicaldaily.com)
  • OBJECTIVE -To determine whether addition of Salba ( Salvia hispanica L .), a novel whole grain that is rich in fiber, α-linolenic acid (ALA), and minerals to conventional treatment is associated with improvement in major and emerging cardiovascular risk factors in individuals with type 2 diabetes. (diabetesjournals.org)
  • CONCLUSIONS -Long-term supplementation with Salba attenuated a major cardiovascular risk factor (SBP) and emerging factors (hs-CRP and vWF) safely beyond conventional therapy, while maintaining good glycemic and lipid control in people with well-controlled type 2 diabetes. (diabetesjournals.org)
  • Now, a study led by Sachin Agarwal involving 114 patients who had been resuscitated following cardiac arrest between 2015 and 2017 has shown that those who developed PTSD were at a three-fold greater risk of experiencing a major cardiovascular event or death from any cause, compared with those who did not develop PTSD. (news-medical.net)
  • MONDAY, April 17, 2017 (HealthDay News) -- The risk of major bleeding is similar for older patients with atrial fibrillation taking either antiplatelet or anticoagulant drugs, according to a review published online April 10 in the Journal of Thrombosis and Haemostasis . (doctorslounge.com)
  • A new study has discovered that a genetic predisposition for major depression also increases an individual's risk for a suicide attempt. (psychcentral.com)
  • The finding of a shared genetic link between suicide attempt and major depression comes from the largest genome-wide association study (GWAS) to date on suicide attempts. (psychcentral.com)
  • Researchers at the Icahn School of Medicine at Mount Sinai found that a genetic liability for major depression increases an individual's risk for suicide attempts regardless of an individual's mental health diagnosis. (psychcentral.com)
  • Using polygenic risk scores, which summarize an individual's genetic liability to a disease based on the results of an independent genetic study, the research team showed that suicide attempters carry an increased genetic liability for depression, regardless of the psychiatric disorder they are affected by. (psychcentral.com)
  • These results indicate the existence of a shared genetic etiology between suicide attempt and major depression that is common to suicide attempt in different psychiatric disorders," says Dr. Mullins. (psychcentral.com)
  • A global research project has mapped out the genetic basis of major depression, identifying 44 genetic variants which are risk factors for depression, 30 of which are newly discovered. (eurekalert.org)
  • The study, by the Psychiatric Genomics Consortium and co-led in the UK by King's College London, is the largest study to-date of genetic risk factors for major depression. (eurekalert.org)
  • Published today in Nature Genetics , the research finds that the genetic basis for major depression is shared with other psychiatric disorders such as schizophrenia, and that all humans carry at least some of the 44 genetic risk factors identified in the study. (eurekalert.org)
  • Analysis of the data also suggests that having higher BMI is linked to an increased risk of major depression. (eurekalert.org)
  • By combining seven separate datasets, the research team included data on more than 135,000 people with major depression and more than 344,000 controls. (eurekalert.org)
  • Major depression affects approximately 14% of the global population and is the biggest contributor to long term disability in the general population worldwide. (eurekalert.org)
  • We need further research to uncover more of the genetic underpinnings, and to understand how genetics and environmental stressors work together to increase risk of depression. (eurekalert.org)
  • The combined findings from previous studies prompted Saito's team to speculate that metabolites of the kynurenine pathway may serve as biomarkers that could allow early detection of patients at risk of developing depression. (genengnews.com)
  • Compared to control individuals, the patients-both men and women-at risk of depression had increased serum levels of anthranilic acid. (genengnews.com)
  • They carried out additional analyses on samples and data from 33 patients at risk of depression, whose scores on a clinical depression scale at different time points indicated regression from a healthy state to a depressed state. (genengnews.com)
  • Washington, March 6 (ANI): A new study has shown that major depression more than doubles the risk of dementia among adults with diabetes. (thaindian.com)
  • Diabetes alone has shown to be a risk factor for dementia, as has major depression by itself," said the lead author of the study, Dr. Wayne Katon, University of Washington (UW) professor of psychiatry and behavioral sciences. (thaindian.com)
  • A history of depression more than doubles the subsequent risk of Alzheimer's disease and other forms of dementia in the general population. (thaindian.com)
  • We wanted to determine the effects of both conditions - diabetes and major depression-occurring together. (thaindian.com)
  • Our analysis suggests that major depression more than doubles the risk of dementia in adults with diabetes," Katon said. (thaindian.com)
  • Mental health issues, particularly depression and post-traumatic stress disorder, also increase in the wake of major earthquakes. (drugs.com)
  • Newswise - Washington, DC (March 27, 2014) - Major depression may increase diabetes patients' risk of developing kidney failure, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society of Nephrology (CJASN). (newswise.com)
  • additional studies are needed to determine whether treatment of depression can reduce the risk of kidney failure. (newswise.com)
  • Previous research has demonstrated that, if exposed to multiple stressful events, people with a certain (short allele) variant of the serotonin transporter gene are more likely to develop major depression compared with those who have different, long allele of the same gene. (kcl.ac.uk)
  • People with low-level depressive symptoms, who perceive that they have poor quality social support from other people, and with a past history of depression, were at particularly high risk to develop new major depression within the one-to-four year time period of the study," Lyness said. (healthcanal.com)
  • This is good news, as we in the field are just learning how to prevent depression in particular high-risk groups. (healthcanal.com)
  • Future work will be able to test whether any of a variety of treatments-perhaps psychotherapy, perhaps medication, perhaps other things such as exercise-will help to prevent depression in persons suffering from the risks we identified in this study. (healthcanal.com)
  • They were recruited from private practices and University-affiliated clinics in internal medicine, geriatrics and family medicine in Monroe County, N.Y. Only participants without an active diagnosis of major depression were included in the analyses. (healthcanal.com)
  • Thirty-three participants, or about 5.3 percent, developed an episode of major depression during the study period. (healthcanal.com)
  • This means the fully effective preventive treatment of five individuals presenting the indicators would prevent one new case of major depression. (healthcanal.com)
  • Given the compli-cations of depression in an elderly population, a preventive approach for this at-risk population may be quite important to not only prevent psychological suffering but to also avoid the deleterious effects of depression on comorbid medical illness," Taylor wrote. (healthcanal.com)
  • For patients with T2D, other risk factors for falls were: being female (60% increased risk), being aged over 65 years (32%), use of selective serotonin receptor inhibitors (SSRIs) (used to treat depression) (32%), use of opioids (9%), SSRIs and opioids combined (60%), and a history of alcohol abuse (a near doubling of risk). (sciencecodex.com)
  • Teens diagnosed with two of the most common mood disorders, major depression and bipolar disorder, need to be monitored for cardiovascular disease. (medicaldaily.com)
  • Two of the most common mood disorders, major depression and bipolar disorder, affect about 10 percent of teens in the United States. (medicaldaily.com)
  • A newly released scientific statement from the American Heart Association urges early monitoring of teens diagnosed with major depression or bipolar disorder for cardiovascular disease. (medicaldaily.com)
  • A population survey of more than 7,000 American young adults, for instance, found that a diagnosis of clinical depression was associated with increased risk of death due to ischemic heart disease. (medicaldaily.com)
  • PARIS (Reuters) - Being overweight is a major risk for people infected with the new coronavirus and the United States is particularly vulnerable because of high obesity levels there, France's chief epidemiologist said on Wednesday. (reuters.com)
  • Professor Jean-François Delfraissy, who heads the scientific council that advises the government on the epidemic, said as many as 17 million of France's 67 million citizens were seriously at risk from the coronavirus because of age, pre-existing illness or obesity. (reuters.com)
  • Newswise - While the U.S. Centers for Disease Control and Prevention (CDC) advises that people of any age can contract COVID-19, obesity has emerged among the major risk factors for severe cases. (newswise.com)
  • Obesity is a significant factor in the likelihood that someone will be severely affected by COVID-19, a major UK study has found. (yahoo.com)
  • With the aging of the population and the rise in risk factors like obesity, these problems are going to skyrocket, making medical innovation more critical than ever. (silverbook.org)
  • The investigators also found, however, that the rate of major bleeding was not significantly increased with thrombolysis among patients younger than 65 years, whereas it more than tripled in the subgroup of patients older than 65 years. (medscape.com)
  • People who experience post-traumatic stress disorder (PTSD) after surviving cardiac arrest, may be at a significantly increased risk of a major cardiovascular event or death for up to one year following the arrest, compared with people who do not develop PTSD. (news-medical.net)
  • Use of valproic acid monotherapy was associated with significantly increased risks for 6 of the 14 malformations under consideration. (womensmentalhealth.org)
  • Spouses of patients are also shown to be at a significantly increased risk of developing the disease, underscoring the very powerful role of environmental and behavioral factors, most notably smoking. (decode.com)
  • However, cancer risk varies by the specific type of birth defect, and is not significantly increased in many of the more common birth defects. (utah.edu)
  • Among adult Chinese, AFO was associated with significantly increased risks of major vascular morbidity and mortality. (dovepress.com)
  • A perfect example, a recent study 1 reveals, is the discovery that people with colon cancer who add extra fiber to their overall food intake may have a lower risk of mortality compared to people who don't consume much fiber. (mercola.com)
  • In a meta-analysis of 16 randomized studies comparing thrombolytic therapy with anticoagulation therapy in patients with pulmonary embolism, including intermediate-risk, hemodynamically stable patients with right ventricular dysfunction, Chatterjee et al found that thrombolytic therapy, as compared with standard anticoagulant therapy, reduced mortality by 47% but was associated with a 2.7-fold increase in major bleeding. (medscape.com)
  • Background - Major hemorrhagic events are associated with significant morbidity and mortality. (ices.on.ca)
  • Understanding the complex relationship between these two traits is critical to reducing early mortality, as comorbid MDD is associated with a fivefold increased risk of cardiac mortality within 6 months of a myocardial infarction [ 3 ]. (nature.com)
  • In addition to the frequently documented, but poorly understood, relationship between MDD and cardiac health, recent evidence also strongly suggests that chronic loneliness-independent from MDD-similarly increases the risk of heart disease and early mortality. (nature.com)
  • Breast cancer incidence and mortality measured for the population of a major metropolitan center included 7368 cases and 2357 deaths over 15 years, ascertained according to National Cancer Institute Surveillance, Epidemiology, and End Results program procedures. (nih.gov)
  • Compared to community-wide reference incidence and mortality rates, significant excess breast cancer risks were identified for housewives, registered nurses, clinical laboratory technicians, schoolteachers, social workers, secretaries and typists, and meat wrappers and cutters. (nih.gov)
  • Overall transplant-related mortality (TRM) varies between 10 and 50% and is mainly due to the occurrence of major transplant-related complications (MTC) during the first months after BMT, including: infections, hepatic veno-occlusive disease (VOD), acute graft-versus-host disease (AGVHD), pneumonitis and severe endothelial leakage syndrome (ELS). (nature.com)
  • Little is known about nonrespiratory disease risks, especially vascular morbidity and mortality after developing airflow obstruction (AFO) in Chinese adults. (dovepress.com)
  • We aimed to investigate the prospective association of prevalent AFO with major vascular morbidity and mortality. (dovepress.com)
  • Gaining further information on risk factors for falls could guide the management of diabetes treatment such as the choice of medication, which enables us to improve treatment particularly in people with a high risk of falls and fractures associated with high mortality. (sciencecodex.com)
  • It has long been recognized that certain metabolic conditions are associated with cardiovascular disease and increased risk for morbidity and mortality. (psychiatrictimes.com)
  • Although these past findings do not demonstrate causality," the authors noted, "they are based on large samples and… provide a basis for hypothesizing that the spectrum of BD, MDD, suicide attempts, and even anxiety in adolescents and young adults may confer increased risk of subsequent cardiovascular disease and cardiovascular mortality. (medicaldaily.com)
  • Pavel Kabat, Chief Scientist of the World Meteorological Organization (WMO), spoke on behalf of that body's Secretary-General, highlighting findings from the newly published Global Risks Report 2019, which indicate that extreme weather, natural disasters, climate change and water crises are the top four existential threats to the planet, demonstrating significant links with other shocks and impacts on peace and security as well as sustainable development. (un.org)
  • The Flood-risk management project for Cagayan River, Tagoloan River, and Imus River (FRIMP-CTI), which commenced in April 2016, will be completed by March 2019. (thefreelibrary.com)
  • OBJECTIVE To examine the global prevalence and major risk factors for diabetic retinopathy (DR) and vision-threatening diabetic retinopathy (VTDR) among people with diabetes. (diabetesjournals.org)
  • Katon and the other authors noted that various other population studies have shown that the risk of Alzheimer's disease, vascular dementia, and other types of dementia is from 40 percent to 100 percent higher in people with diabetes, compared to people without diabetes. (thaindian.com)
  • Moreover, earthquake victims with chronic diseases, like diabetes and heart disease, are at greater risk of death due to limited access to medical care. (drugs.com)
  • This is the first study to show that major depressive symptoms are associated with a higher risk of kidney failure in patients with diabetes," said Dr. Yu. (newswise.com)
  • Also, because the association was not entirely explained by differences in traditional risk factors for kidney disease or diabetes self-care characteristics, more research is needed to determine the mechanisms involved. (newswise.com)
  • Researchers at UCLA's Longevity Institute tested the effects of the "fasting-mimicking diet" on various risk factors for diabetes, heart disease, cancer or other conditions. (lesliebeck.com)
  • While most participants had one or more risk factors for diseases such as diabetes, heart disease or cancer, the researchers stated that FDA trials will be necessary to demonstrate whether periodic FMD is effective in disease prevention and treatment. (lesliebeck.com)
  • Objective To examine the association between maternal type 1 diabetes and the risk of major birth defects according to levels of glycated haemoglobin (HbA1C) within three months before or after estimated conception. (bmj.com)
  • Results 122 cases of major cardiac defects were observed among 2458 infants of mothers with type 1 diabetes. (bmj.com)
  • 50 cases of major non-cardiac defects were observed among infants of mothers with type 1 diabetes. (bmj.com)
  • Conclusion Among liveborn infants of mothers with type 1 diabetes, increasingly worse glycaemic control in the three months before or after estimated conception was associated with a progressively increased risk of major cardiac defects. (bmj.com)
  • People with diabetes can be at increased risk of falls as they tend to have more complications (for example high and low blood sugar), and use of medication compared with the general population without diabetes. (sciencecodex.com)
  • This study aimed to estimate the risk of falls and to identify risk factors associated with increased falls in people with diabetes compared with the general population. (sciencecodex.com)
  • However, despite an armamentarium of medications and lifestyle therapy, these goals are often difficult to achieve, placing people with diabetes at increased CVD risk. (diabetesjournals.org)
  • Collective endorsement of whole grains by major health agencies around the world, including the Food and Drug Administration-approved health claim ( 1 ), is based on large epidemiological and prospective population studies that suggest a strong inverse relationship between increased consumption of whole-grain foods and reduced risk of diabetes and CVD ( 2 ). (diabetesjournals.org)
  • Despite recent advances, diabetes continues to be a major health threat for at least 29 million Americans who have it and the 86 million Americans with prediabetes. (silverbook.org)
  • The prospect of a global tit-for-tat poses major disruption risks for auto manufacturers across several fronts. (cips.org)
  • A major natural gas pipeline stretching across southern New York may be at risk of rupturing and poses a safety threat, according to a recent inspection by federal regulators. (propublica.org)
  • Experts have long warned that air pollution poses a risk to health. (iol.co.za)
  • Superintendent Rebecca Boyce said: "Our rationale for declaring a major incident is that if handled or stored incorrectly, Talunex poses a very real risk to public health . (theboltonnews.co.uk)
  • Climate change poses risks to international peace and security through massive displacement of people and increased competition for scarce natural resources, speakers told the Security Council today while expressing divergent views on what the 15-member organ can do about it. (un.org)
  • Their proximity to major roadways was based on their residential postal-code address in 1996. (medscape.com)
  • In addition, they mapped individuals' proximity to major roadways using the postal code of their residence. (eurekalert.org)
  • Risk assessment teams used in the pilot project were primarily composed of mining company personnel. (cdc.gov)
  • When pressed to consider more controls to further mitigate the risk, a well-staffed risk assessment team was able to identify additional controls. (cdc.gov)
  • Additionally, if a mining operation is not prepared to discuss its major hazards in an open and honest fashion and to present the findings of the risk assessment in a written report, the MHRA output will be unclear, and attempts to monitor or audit important controls may not be possible. (cdc.gov)
  • A Major Hazard Risk Assessment (MHRA) was developed in Australia after a series of mine disasters in the 1990's. (cdc.gov)
  • HITRUST MyCSF 2.0 incorporates major updates designed to provide a more flexible and streamlined assessment and third-party review process, corrective action plan management, enhanced benchmarking and dashboards, and integration with major GRC platforms and the HITRUST Assessment XChange. (businesswire.com)
  • HITRUST engaged its customers and HITRUST CSF® Assessors to understand their requirements and leveraged its unique position and experience in framework development and information risk management, combined with hundreds of thousands of risk assessments, in designing the most efficient solution for information risk assessment management. (businesswire.com)
  • We heard and have responded to our customers' request for a solution capable of supporting their evolving assessment needs that aligns with managing risk and the changing global regulatory landscape," said Michael Frederick, Vice President Operations, HITRUST. (businesswire.com)
  • He says that if the new markers were to be taken into account in a risk-assessment model, combined with other factors such as breast density and lifestyle factors, the proportion of women who are identified as being at high risk for developing breast cancer could increase tenfold. (theglobeandmail.com)
  • Associate Level Material Chronic Disease Risk Assessment The Life Resource Center (LRC) is a valuable free tool available to University of Phoenix students. (majortests.com)
  • Chronic Disease Risk Assessment I decided to complete my health risk assessment on the chronic disease colon cancer. (majortests.com)
  • Chronic Disease Risk Assessment Melody Powell Sci/163 April 2, 2013 Tiffany Smith Chronic Disease Risk Assessment Cancer is a large group of different groups of disease caused when abnormal cells divide and attack other tissue and organs. (majortests.com)
  • Looking ahead, the United Nations will invest in certain actions, she said, noting that the Department of Political and Peacebuilding Affairs, the United Nations Development Programme (UNDP) and the United Nations Environment Programme (UNEP), in collaboration with practitioners from across and beyond the Organization, are developing an integrated risk-assessment framework to analyse climate-related security risks. (un.org)
  • Grains will raise your insulin and leptin levels, which is a major driver of most chronic diseases. (mercola.com)
  • Dr. Samantha Hendren, a researcher at the University of Michigan (not involved in the study) maintains what many doctors believe, that the most telling risk factors for colon cancer are family history, a personal history of cancerous polyps, diseases such as ulcerative colitis and failure to get screened for the disease. (mercola.com)
  • For these reasons, then, the authors recommend doctors and other professionals consider the two mood disorders as independent, moderate risk factors for cardiovascular diseases. (medicaldaily.com)
  • Dr. Chen is lead author on the paper titled Living Near Major Roads and the Incidence of Dementia, Parkinson's Disease, and Multiple Sclerosis: A Population-based Cohort Study (embargoed link). (eurekalert.org)
  • This particular algorithm helps hospitals and insurance companies identify which patients will benefit from "high-risk care management" programs, which provide chronically ill people with access to specially trained nursing staff and allocate extra primary-care visits for closer monitoring. (scientificamerican.com)
  • For example, among all patients classified as very high-risk, black individuals turned out to have 26.3 percent more chronic illnesses than white ones (despite sharing similar risk scores). (scientificamerican.com)
  • Because their recorded health care costs were on par with those of healthier white people, the program was less likely to flag eligible black patients for high-risk care management. (scientificamerican.com)
  • But knowing individuals' genetic risk could allow clinicians to identify high-risk patients and screen them at a younger age and more frequently, while those with lower risk may need less-frequent screening, Simard says. (theglobeandmail.com)
  • Major heart surgery (MHS) patients are a particularly high-risk population for nosocomial infections. (nih.gov)
  • VAP is common in patients undergoing MHS that require more than 48 h of MV. In that "high-risk" population, innovative preventive measures should be developed and applied. (nih.gov)
  • However, areas of high risk were also found in drought-prone regions for beech and in the southern Alps for fir. (usda.gov)
  • A study published in the European Heart Journal aimed to establish whether the MedDiet or Western dietary patterns predict adverse outcomes in high-risk patients or in those with stable CHD. (oliveoiltimes.com)
  • Participants were either at high risk of CVD or currently had stable CHD. (oliveoiltimes.com)
  • These estimates are a sobering reminder that gay and bisexual men face an unacceptably high risk for HIV - and of the urgent need for action. (aidsmap.com)
  • Data limitations include absence of population frequencies of personal risk factors for breast cancer, occupation designation errors, lack of knowledge about chemical exposures in apparently high-risk occupations, and the possibility that the number of comparisons could produce significant differences by chance. (nih.gov)
  • Sanjit S. Jolly, M.D., of Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada, and colleagues with the Fondaparinux Trial With Unfractionated Heparin During Revascularization in Acute Coronary Syndromes (FUTURA)/OASIS-8 trial evaluated the safety of two dose regimens of adjunctive intravenous unfractionated heparin during PCI in high-risk patients. (medindia.net)
  • The randomized trial included 179 hospitals in 18 countries and involved 2,026 patients undergoing PCI within 72 hours, who were from a group of 3,235 high-risk patients with non-ST segment elevation acute coronary syndromes initially treated with fondaparinux, enrolled from February 2009 to March 2010. (medindia.net)
  • The report looks at the government's largest, most innovative and high-risk projects and programmes, ranking them based on how likely it is that they will be successful. (publictechnology.net)
  • These findings suggest that the identification of the genes involved might enable the development of better means of treatment, and also of developing diagnostic tests that could identify those who are at a particularly high risk of the disease. (decode.com)
  • Preventive treatments for people in the high-risk group hold promise for providing the greatest health benefit at the lowest cost, the researchers concluded. (healthcanal.com)
  • A high risk severe weather event is the greatest threat level issued by the Storm Prediction Center (SPC) for convective weather events in the United States. (wikipedia.org)
  • However, only 2 occurrences (April 7, 2006 and April 14, 2012) of a day 2 high risk are known. (wikipedia.org)
  • A high risk cannot be issued on day 3. (wikipedia.org)
  • There were no high risk days in 2000. (wikipedia.org)
  • There were no high risk days in 2015, 2016, or 2018. (wikipedia.org)
  • List of Storm Prediction Center extremely critical days List of United States tornado emergencies All values include events that took place outside the high risk area. (wikipedia.org)
  • Tornado and fatality totals only include incidents that occurred on the respective high risk days. (wikipedia.org)
  • Leading public-health scientists highlight in a study in this week's issue of THE LANCET how confronting major risk factors that lead to poor health could have a substantial effect in reducing premature deaths and morbidity globally-especially in the poorest areas of the world. (innovations-report.com)
  • To tease apart these scenarios, we first assessed the medical morbidity pattern associated with genetic risk factors for MDD and loneliness by conducting a phenome-wide association study in 18,385 European-ancestry individuals in the Vanderbilt University Medical Center biobank, BioVU. (nature.com)
  • The researchers examined the three-year cumulative incidence of hospitalization with major nontraumatic hemorrhage after kidney transplantation. (ices.on.ca)
  • The researchers calculated the three-year cumulative incidence, event rate, and incident rate ratio of hospitalization with major hemorrhage, its subtypes and those undergoing a hemorrhage-related procedure. (ices.on.ca)
  • Results - Among 4,958 kidney transplant recipients, the three-year cumulative incidence of hospitalization with nontraumatic major hemorrhage was 3.5% (95% confidence interval [CI] 3.0-4.1%, 12.7 events per 1,000 patient-years) compared to 0.4% (95% CI 0.4-0.5%) in the general population (RR = 8.2, 95% CI 6.9-9.7). (ices.on.ca)
  • During follow-up, 467 SGLT2 inhibitor users (incidence rate 17.0 events per 1000 person years) and 662 DPP4 inhibitor users (18.0) had a major cardiovascular event, whereas 130 (4.7) and 265 (7.1) had a heart failure event, respectively. (bmj.com)
  • The study, published online in The Lancet on January 4, showed a clear dose response in that the risk for dementia increased with the proximity to a major road, with a 7% increased risk when the distance from the road was less than 50 meters, a 4% increase at 50 to 100 meters, and a 2% increase at 100 to 200 meters. (medscape.com)
  • Almost all people (95%) in the study lived within 1 kilometer of a major road and half lived within 200 meters of one. (medscape.com)
  • Now a longitudinal study of more than 7,000 British civil servants who were tested between 1997 and 2016 found those who underwent major operations were twice as likely to suffer substantial cognitive decline compared to those who never needed surgery. (telegraph.co.uk)
  • Using a mobile phone does not appear to increase the risk of developing certain types of brain cancer, the largest study of its kind has concluded. (bbc.co.uk)
  • This study cannot answer whether there are long-term risks beyond fifteen years, nor would it have been able to pick up much, much smaller risks,' says Professor Swerdlow. (bbc.co.uk)
  • Adequate fiber intake is so crucial to health, asserts senior study author Dr. Andrew Chan of Harvard Medical School and Massachusetts General Hospital in Boston, that consuming more fiber after such a diagnosis can positively impact patients' risk of dying from the disease, independent of how much fiber those patients ate before the diagnosis. (mercola.com)
  • 2 Another researcher, Nour Makarem, at Columbia University in New York (and also not involved in Chan's study), said that for her part, diet is very important, particularly as it relates to dietary fiber, as eating foods high in fiber can lower the risk of developing colon cancer. (mercola.com)
  • A study published Thursday in Science has found that a health care risk-prediction algorithm, a major example of tools used on more than 200 million people in the U.S., demonstrated racial bias-because it relied on a faulty metric for determining need. (scientificamerican.com)
  • Modern treatment methods applied within 24 hours of symptoms are credited with the risk for secondary stroke being cut in half in a recent study. (upi.com)
  • WASHINGTON, April 21 (UPI) -- Better and faster use of secondary stroke prevention methods after transient ischemic attacks, or TIAs, helps reduce risk of additional strokes and death, according to researchers involved with an international study. (upi.com)
  • With the most aggressive care available, researchers at 21 sites around the world cut in half the risk of a second stroke among participants in the five-year study, which is published in the New England Journal of Medicine . (upi.com)
  • At 90 days, for example, the researchers report expectations of 12 to 20 percent risk for cardiovascular event or stroke but participants in the new study were at just 3.7 percent risk. (upi.com)
  • A prospective study of venous thromboembolism after major trauma. (medscape.com)
  • Children living close to a major road are significantly more likely to have asthma than children who live farther away, according to a study presented today at the American Thoracic Society International Conference on May 23. (innovations-report.com)
  • The study found that children living within 75 meters (about 82 yards) of a major road had an almost 50 percent greater risk of having had asthma symptoms in the past year than were children who lived more than 300 meters (about 328 yards) away. (innovations-report.com)
  • London - Air pollution significantly raises the risk of babies dying in their first year, a major study has found. (iol.co.za)
  • The study found that three air pollutants - particulate matter known as PM10, nitrogen dioxide and sulphur dioxide - separately and in combination are associated with a 20 to 50 percent increased risk of death for babies born in the most polluted areas. (iol.co.za)
  • Majid Ezzati comments: "This study shows that the potential health gains from reducing major known but often over-looked risks are enormous, especially for those societies that currently endure the worst health conditions. (innovations-report.com)
  • A large study published in the New England Journal of Medicine attempted to clarify the risks associated with first trimester exposure to valproic acid. (womensmentalhealth.org)
  • The authors then conducted a population-based, case-control study to assess the risk of these malformations using the antiepileptic study database established by the European Surveillance of Congenital Anomalies (EUROCAT). (womensmentalhealth.org)
  • The study sample consisted of 3,881,592 live births and stillbirths, of which 98,075 involved a major congenital malformation. (womensmentalhealth.org)
  • Also included were 39,472 controls with major malformations other than those under study (control group 1) and 11,763 controls with malformations associated with chromosomal abnormalities (control group 2). (womensmentalhealth.org)
  • In a recent study, the Mediterranean diet decreased the risk of adverse events for patients with cardiovascular disease, while surprisingly the Western diet showed no association for an adverse risk. (oliveoiltimes.com)
  • The researchers reported that the primary outcome of the study "was the first occurrence of major adverse cardiac events (MACE) defined as non-fatal myocardial infarction, non-fatal stroke, or death from a CV cause during a median follow-up of 3.7 years. (oliveoiltimes.com)
  • The results of the study showed that a higher MDS score is significantly associated with lower risk of CVD death, myocardial infarction, stroke and all-cause death. (oliveoiltimes.com)
  • Therefore, while the MedDiet clearly shows a decreased risk, the Western dietary pattern was not shown to increase risk of adverse outcomes in this study, which was an unexpected result. (oliveoiltimes.com)
  • Sept. 11, 2011 - In a study that included nearly 70,000 patients, supplementation with omega-3 polyunsaturated fatty acids was not associated with a lower risk of all-cause death, cardiac death, sudden death, heart attack, or stroke, according to an analysis of previous studies published in the September 12 issue of the Journal of the American Medical Association (JAMA) . (seniorjournal.com)
  • A study of an outbreak of measles in Gothenburg a year ago shows large differences in the risk of transmission from one patient to another. (gu.se)
  • Older people who experience significant weight gain or weight loss could be raising their risk of developing dementia, suggests a study from South Korea. (nursingtimes.net)
  • The lifetime risk of being diagnosed with HIV in the US has decreased overall during the past decade, falling to 1 in 99, according to a study from the Centers for Disease Control and Prevention (CDC) presented at the Conference on Retroviruses and Opportunistic Infections (CROI 2016) this week in Boston. (aidsmap.com)
  • A study that will appear in the September 22 issue of JAMA says that patients with acute coronary syndromes initially treated with the anticoagulant fondaparinux who underwent a coronary procedure and received a lower dose of the anticoagulant heparin during the procedure did not have a reduced rate of major bleeding and vascular access site complications. (medindia.net)
  • The authors note that the major finding of this study is that low fixed-dose heparin is not superior to standard ACT-guided heparin dosing (after the use of fondaparinux) in terms of preventing peri-PCI major bleeding or major vascular access site complications. (medindia.net)
  • In our study, there was no clinical benefit to using the experimental low-dose regimen, except for a reduction in minor bleeding alone (but not in the combination of major and minor bleeding)," the authors write. (medindia.net)
  • A major register study from the Swed. (bio-medicine.org)
  • A major register study from the Swedish medical university Karolinska Institutet shows that children born to certain groups of immigrants in Sweden had an increased risk of developing autism with intellectual disability. (bio-medicine.org)
  • The study, entitled "Familial risk of lung carcinoma in the Icelandic population," appears in the December 22nd edition of JAMA and in the online edition of the journal. (decode.com)
  • Following a diet that mimics fasting may reduce risk factors for disease in generally healthy people, according to a small study. (lesliebeck.com)
  • Results Mean age of the study cohort was 61 years, 60% were men, and 19% had a history of major cardiovascular disease. (bmj.com)
  • SALT LAKE CITY - A multistate study led by researchers at the University of Utah has revealed that the risk for childhood cancer is moderately increased among children and young adolescents with certain types of major birth defects. (utah.edu)
  • Children born with non-chromosomal birth defects have a twofold higher risk of cancer before age 15, compared to children born without birth defects, according to this study published in July in PLOS ONE . (utah.edu)
  • There is a large body of evidence for increased cancer risk in children with Down's syndrome, a genetic birth defect caused by the presence of an extra copy of chromosome 21," says Lorenzo Botto , M.D., professor of pediatrics at the University of Utah School of Medicine and first author on the study. (utah.edu)
  • In this study, funded by the U.S. Centers for Disease Control and Prevention (CDC), Botto and his colleagues analyzed information from birth defect and cancer surveillance programs in Utah, Arizona and Iowa and observed that cancer risk was increased in children born with eye defects, cleft palate, some heart and kidney defects, and microcephaly, a condition where the head is smaller than normal. (utah.edu)
  • Our study helps to identify who is, and who is not, at increased risk for cancer, and this information can be used to focus future research on potential genetic or environmental factors that contribute to cancer risk. (utah.edu)
  • CORVALLIS, Ore. -- From low-income countries to high-income countries, long-term exposure to fine particulate outdoor air pollution is a major contributor to cardiovascular disease and death, a new Oregon State University study found. (brightsurf.com)
  • Undergoing weight loss surgery has been linked with a 40% lower risk of having a major cardiovascular event, such as heart disease or stroke, according to a new study. (diabetes.co.uk)
  • Our aim was to study the broader eating patterns that potentially reflect many dietary exposures working together in their association with breast cancer risk. (aacrjournals.org)
  • Using data from a prospective study of 61,463 women with an average follow-up of 9.6 years and 1,328 incident cases of breast cancer, we conducted a factor analysis to identify major dietary patterns. (aacrjournals.org)
  • Therefore, using factor analysis, we identified and examined major dietary patterns and their relation to breast cancer risk in a large prospective cohort study. (aacrjournals.org)
  • In a study analysing sport and recreation related injuries in Victoria between 2001 and 2007, researchers found major trauma, including deaths, had increased by 10 per cent each year with the highest number of deaths attributed to off-road motor sports, including motor-bikes and fishing. (healthcanal.com)
  • Analysing data from the Victorian State Trauma Registry (VSTR) and the National Coroners Information System, researchers led by Monash University's Dr Nadine Andrew, recorded 1019 non-fatal major trauma cases and 218 deaths during the six-year study period. (healthcanal.com)
  • A separate Taiwanese national health insurance study - involving more than a million participants of all ages - found a link between MDD, BD, and anxiety disorder diagnoses and higher risk of IHD. (medicaldaily.com)
  • Risk of NHL, diffuse large B cell lymphoma (DLBCL) and chronic lymphatic leukaemia (CLL) did not increase with plasma levels of HCB, β-HCH, p,p′ -dichloro-diphenyl-dichloroethylene (DDE), or total and individual PCBs or their functional groups, in the overall study population. (bmj.com)
  • Results from a retrospective, observational real-world study examining major bleed and stroke rates in non-valvular atrial fibrillation (NVAF) patients taking novel oral anticoagulants (NOACs) were presented at the International Stroke Conference 2018. (empr.com)
  • HealthDay News) - A statistical tool can accurately estimate an individual patient's risk of developing a major complication after surgery for oral cavity squamous cell carcinoma, according to a study published online October 15 in JAMA Otolaryngology-Head & Neck Surgery . (empr.com)
  • This study provides proof of principle that nomograms can allow clinicians to anticipate which patients are at higher risk of developing complications after surgery, thereby facilitating timely recognition and effective management of postoperative complications," conclude the authors. (empr.com)
  • The purpose of this study is to determine if treatment with bempedoic acid (ETC-1002) versus placebo decreases the risk of cardiovascular events in patients who are statin intolerant. (centerwatch.com)
  • This study was set in the outpatient clinic of the Risk Factor Modification Center, St. Michael's Hospital, Toronto, Canada. (diabetesjournals.org)
  • In these groups, the risk of recurrence was reduced in the study by 23% (p=0.004) and 26% (p=0.03), respectively. (webwire.com)
  • It is great news to see that in patients with more than four years of median follow-up from this important trial, the results clearly confirm earlier findings that letrozole offers these women an effective hormonal therapy to lower the risk of breast cancer returning or spreading after surgery, said Prof. Beat Th rlimann of St. Gallen, Switzerland, and the BIG 1-98 Trial study chair. (webwire.com)
  • Follow-up of the patients over the course of more than a year found that 29 people (25.4%) experienced a major cardiovascular event such as heart attack, heart failure, severe chest pain, clogged arteries requiring an emergency procedure or an event requiring the implantation of a defibrillator or pacemaker. (news-medical.net)
  • It shows a very straightforward result - the closer you live to a major highway the higher your risk of dementia. (medscape.com)
  • Researchers found that miners heavily exposed to diesel exhaust had a higher risk of dying from lung cancer. (dailymail.co.uk)
  • But they also dismissed as problematic the finding that at the other extreme end of the spectrum those using the phone for the longest cumulative periods, more than 1,640 hours, appeared to have a higher risk, regardless of over what period of time this was spread. (bbc.co.uk)
  • They also have a significantly higher risk of asthma, arthritis, cancer and the sexually transmitted disease chlamydia. (womensenews.org)
  • People who live close to high-traffic roadways face a higher risk of developing dementia than those who live further away, new research from Public Health Ontario (PHO) and the Institute for Clinical Evaluative Sciences (ICES) has found. (eurekalert.org)
  • The crude risk of hemorrhage was 3-9-fold higher in all subtypes (upper/lower gastrointestinal, intra-cranial) and 15-fold higher for gastrointestinal endoscopic procedures compared to the random sample from the general population. (ices.on.ca)
  • Conclusion - Kidney transplantation recipients have a higher risk of hospitalization with hemorrhage compared to the general population, with about 1 in 30 recipients experiencing a major hemorrhage in the three years following transplant. (ices.on.ca)
  • The most polluted ones saw between 20 to 40 percent higher death rates among infants aged up to one year, 20 to 40 percent higher risks of deaths within 28 days of birth and 30 to 50 percent for post-neonatal deaths between 28 days and a year. (iol.co.za)
  • Children are often at higher risk of injury and death than are adults during earthquakes, the researchers said. (drugs.com)
  • Being able to have better risk prediction and targeting interventions to women at higher risk will help us to have early detection," he said, noting that catching cancer early would mean requiring less-invasive treatment, improving patients' quality of life and increasing their chances of survival. (theglobeandmail.com)
  • Diabetics with major depressive symptoms had an 85% higher risk of developing kidney failure. (newswise.com)
  • Adolescent girls were at a higher risk of interacting drug regimens compared to other groups, largely because of their higher rate of medication use. (go.com)
  • Major bleeding might be higher with warfarin than aspirin in patients over 80 years old, according to subgroup analysis. (doctorslounge.com)
  • Across all racial/ethnic groups, the lifetime risk of HIV diagnosis was higher for men (1 in 64) than for women (1 in 227). (aidsmap.com)
  • Estimated diagnosis rates among Hispanics/Latinos (1 in 48 for men and 1 in 227 for women) and Pacific Islanders (1 in 82 for men and 1 in 385 for women) were lower, but still considerably higher than the risk for white people (1 in 132 for men and 1 in 880 for women) or Asian Americans (1 in 174 for men and 1 in 883 for women). (aidsmap.com)
  • Native American men had about the same risk as white men (1 in 129), while Native women had a much higher risk than white women (1 in 399). (aidsmap.com)
  • Higher risk of autism among certain immigr. (bio-medicine.org)
  • The results demonstrate that even cousins of those who have been diagnosed with lung cancer are at a significantly higher risk of developing the disease than are members of the population at large. (decode.com)
  • Since the familial risk of lung cancer was higher than the familial risk for smoking - even beyond the nuclear family - the authors conclude that there are indeed genetic factors that contribute significantly to the likelihood of developing lung cancer, and most particularly in early-onset forms of the disease. (decode.com)
  • The scientists also observed that cancer risk was 14 times higher among children with Down syndrome, mainly due to leukemias. (utah.edu)
  • This combination increases the risk for RMIs. (ccohs.ca)
  • Although each variant only increases the risk of cancer modestly, when combined the risks are multiplied, says Dr. Jacques Simard of the Genomic Centre at CHU de Québec-Université Laval Research Centre, one of the scientists involved in the project. (theglobeandmail.com)
  • Our results are in agreement with the majority of previous studies that show alcohol consumption moderately increases the risk of breast cancer, but our results do not support any association between breast cancer risk and the "Western" or "healthy" dietary patterns. (aacrjournals.org)
  • The report noted that people with brain tumours were more likely to overestimate the role of a potential risk factor, and that the disease interferes with memory and cognition, undermining the accuracy of the recollections of such extreme use. (bbc.co.uk)
  • The extreme fatigue of long hours is another risk factor for nearly all types of injuries. (umn.edu)
  • The investigators used comprehensive reviews of data on risk-factor levels and epidemiological studies in their estimates. (innovations-report.com)
  • Metabolic syndrome: a multiplex cardiovascular risk factor. (psychiatrictimes.com)
  • Noise is a major factor in many military environments. (wind-watch.org)
  • Meanwhile, a suicide attempt was found to be the number one risk factor in young women, number four in young men, for a death resulting from heart disease caused by narrowed/clogged arteries. (medicaldaily.com)
  • It is little surprise that risk managers and underwriting insurance specialists are some of the most sought-after talent in the world with the industry net-worth predicted to be US $80-billion by 2020. (iafrica.com)
  • On the eve of the African Vaccination Week - the annual campaign for universal access to life-saving vaccines on the continent - new, early data shows that an estimated 16.6 million children in Africa missed planned supplemental measles vaccine doses between January 2020 and April 2021 and eight African countries reported major measles outbreaks that affected tens of thousands during the period. (who.int)
  • As Audit teams start thinking about their 2018 plans, being able to identify new trends in emerging risk areas that threaten to disrupt enterprise performance over the next year is critical. (corporatecomplianceinsights.com)
  • The roadways include major interstate and state roads throughout the United States. (redorbit.com)
  • The findings provide new evidence that long-term exposure to roadways is associated with increased risk for death, including in patients with underlying cardiovascular disease, he said. (redorbit.com)
  • From the public policy point of view, the association between risk of death and proximity of housing to major roadways should be considered when new communities are planned," Mittleman said. (redorbit.com)
  • It) also improves outcomes and reduces risk of death among colorectal cancer survivors. (mercola.com)
  • In eight studies including a total of 1565 pregnancy outcomes, there were 118 major malformations as defined by EUROCAT . (womensmentalhealth.org)
  • Treatment with marine-derived omega-3 polyunsaturated fatty acids (PUFAs) for the prevention of major cardiovascular adverse outcomes has been supported by a number of randomized clinical trials (RCTs) and refuted by others. (seniorjournal.com)
  • Evangelos C. Rizos, M.D., Ph.D., of the University Hospital of Ioannina, Ioannina, Greece, and colleagues performed a large-scale synthesis of the available randomized evidence by conducting a systematic review and meta-analysis to determine the association between omega-3 PUFAs and major cardiovascular outcomes. (seniorjournal.com)
  • In conclusion, omega-3 PUFAs are not statistically significantly associated with major cardiovascular outcomes across various patient populations. (seniorjournal.com)
  • Main outcome measures Primary outcomes were major cardiovascular events (composite of myocardial infarction, stroke, and cardiovascular death) and heart failure (hospital admission for heart failure or death due to heart failure). (bmj.com)
  • This report, part of GAO's performance and accountability series, discusses the major management challenges and program risks facing the Social Security Administration (SSA). (gao.gov)
  • As part of its Performance and Accountability Series, GAO provided information on the major management challenges and program risks facing the Department of Agriculture (USDA). (gao.gov)
  • deCODE is a global leader in gene discovery " our population approach and resources have enabled us to isolate key genes contributing to major public health challenges from cardiovascular disease to cancer, genes that are providing us with drug targets rooted in the basic biology of disease. (decode.com)
  • Describing climate change as a risk multiplier that exacerbates already existing challenges, he warned that without swift action to address it, more than 140 million people in sub-Saharan Africa, Latin America and South Asia will be forced to migrate within national borders by 2050. (un.org)
  • Hazard ratios were 0.94 (95% confidence interval 0.84 to 1.06) for major cardiovascular events and 0.66 (0.53 to 0.81) for heart failure. (bmj.com)
  • The increase in the risk of developing dementia went down to four per cent if people lived 50-100 metres from major traffic, and to two per cent if they lived within 101-200 metres. (eurekalert.org)
  • Empirical results from major league baseball using a binary choice probit model, which corrects for sample selection bias, support the hypothesis that factors, which increase market uncertainty and reduce productive uncertainty, are consistent with the observation of long-term contracts. (repec.org)
  • Research shows that dairy producers were at greater risk for serious injury rises rapidly as they increase their work hours. (umn.edu)
  • The sooty particulates and nitrogen dioxide pumped out by traffic and sulphur dioxide from industrial emissions are each linked to an increase in risk, researchers from Cardiff University found. (iol.co.za)
  • Mutations of the BRCA1 and BRCA2 genes have previously been known to greatly increase a woman's risk of developing breast and ovarian cancers. (theglobeandmail.com)
  • We conclude that genetic risk factors for MDD and loneliness act pleiotropically to increase CAD risk in females. (nature.com)
  • There was a nonsignificant increase in the key secondary outcome (peri-PCI major bleeding [near the time of the PCI procedure], death, heart attack, and target revascularization at 30 days), 5.8 percent in the low-dose group vs. 3.9 percent in the standard-dose group. (medindia.net)
  • The finding that adding ACT-guided unfractionated heparin to fondaparinux while treating patients with acute coronary syndromes does not increase major bleeding is important in the context of modern PCI practice. (medindia.net)
  • This corresponds to a 50% increase in risk of T2D per copy carried (there are two copies of each chromosome in every cell). (decode.com)
  • For all of the cohorts combined, the at-risk allele confers an increase in risk of approximately 45% for those carrying one copy, and a 141% increase in risk for individuals carrying two copies. (decode.com)
  • There's an increase in catastrophes, and other risks that are affecting the environment, society as well as technology. (iafrica.com)
  • It's reassuring that many of the common major birth defects are not associated with any increase in cancer risk," says Botto. (utah.edu)
  • Much of the increase in major injuries and deaths can be attributed to increases in major trauma rates associated with off-road motor sports, cycling and Australian football," Dr Andrew said. (healthcanal.com)
  • There is conflicting epidemiological evidence concerning an increase in risk of non-Hodgkin's lymphoma (NHL) associated with elevated blood levels of persistent organochlorine (OC) pesticides and polychlorobiphenyls (PCBs). (bmj.com)
  • Black patients, the researchers found, tended to receive lower risk scores. (scientificamerican.com)
  • The researchers found that the overall lifetime risk of an HIV-positive diagnosis was lower than it was a decade ago, falling from about 1 in 78 during 2004-2005 to 1 in 99 during 2009-2013. (aidsmap.com)
  • The researchers found that the primary composite outcome (major bleeding, minor bleeding, or major vascular access site complications up to 48 hours after PCI) occurred in 4.7 percent of the patients in the low-dose group and 5.8 percent in the standard-dose group. (medindia.net)
  • An aggressive reduction in major risk factors for cardiovascular disease (CVD), such as elevated blood pressure and dyslipidemia, as well as emerging risk factors, including proinflammatory and prothrombotic markers, is recommended. (diabetesjournals.org)
  • Risk factors such as age, sex, diabetic complications, a history of alcohol abuse and a history of medication were included in an adjusted analysis. (sciencecodex.com)
  • Domestic violence and children: prevalence and risk in five major U.S. cities. (nih.gov)
  • The findings indicate that living close to major roads increased the risk of developing dementia, but not Parkinson's disease or multiple sclerosis, two other major neurological disorders. (eurekalert.org)
  • Our findings show the closer you live to roads with heavy day-to-day traffic, the greater the risk of developing dementia. (eurekalert.org)
  • As urban centres become more densely populated and more congested with vehicles on major roads, Dr. Copes suggests the findings of this paper could be used to help inform municipal land use decisions as well as building design to take into account air pollution factors and the impact on residents. (eurekalert.org)
  • The findings highlight the need for our public health system to put greater emphasis on disease prevention by recognizing clusters of risk factors and designing policies and programs for addressing them, rather than merely treating their consequences. (innovations-report.com)
  • However, studies to date have provided inconsistent findings on cancer risk in children with structural birth defects that are not caused by chromosome abnormalities. (utah.edu)
  • The (expert) working group found that diesel exhaust is a cause of lung cancer and also noted a positive association with an increased risk of bladder cancer,' it said in a statement. (dailymail.co.uk)
  • Unlike lung cancer, where the risk rises the more cigarettes are smoked, this mobile phone data shows no increased risk until the very heaviest use begins. (bbc.co.uk)
  • Cigarette smoking and lung cancer--relative risk estimates for the major histological types from a pooled analysis of case-control studies. (nih.gov)
  • By using one of the largest lung cancer datasets ever assembled, we explored the impact of smoking on risks of the major cell types of lung cancer. (nih.gov)
  • The major result that smoking exerted a steeper risk gradient on SqCC and SCLC than on AdCa is in line with previous population data and biological understanding of lung cancer development. (nih.gov)
  • In the as-treated analyses, hazard ratios were 0.84 (0.72 to 0.98) for major cardiovascular events, 0.55 (0.42 to 0.73) for heart failure, 0.93 (0.76 to 1.14) for myocardial infarction, 0.83 (0.64 to 1.07) for stroke, 0.67 (0.49 to 0.93) for cardiovascular death, and 0.75 (0.61 to 0.91) for any cause death. (bmj.com)
  • While seven of these countries have now completed the campaigns, eight remain outstanding, posing a risk of major measles outbreaks. (who.int)
  • This could include further controls on traffic-related emissions, planning future land use so that major roads are positioned away from residential areas, and improvements to buildings that are near major roads to protect against air pollution, he said. (medscape.com)
  • This is a potentially important public health problem because there are many children who live near major roads. (innovations-report.com)
  • Although newer treatment for "mini-strokes" cut the risk for secondary stroke or cardiovascular event in half from previous studies, researchers say the results may not reflect all available care because 100 percent of patients were treated at facilities specifically equipped for stroke patients. (upi.com)
  • The researchers report that one year after TIA, the risk for a cardiovascular event was 6.2 percent and risk of a stroke was 5.1 percent. (upi.com)
  • The risk of recurrent stroke 2 days, 7 days, 30 days, 90 days and 1 year after treatment was about half what was expected based on previous studies. (upi.com)
  • Main:Time to first occurrence of major adverse cardiovascular event, which is a composite of CV death, non-fatal MI, and stroke. (clinicaltrials.gov)
  • There were also increased risks of hemorrhagic stroke (n=823, HR 1.18, 95% CI 1.09-1.27), major coronary events (n=635, HR 1.33, 95% CI 1.22-1.45), and heart failure (n=543, HR 2.19, 95% CI 1.98-2.41). (dovepress.com)
  • Hystad says a growing body of research finds that the risk of stroke is strongly impacted by exposure to PM2.5, especially at high concentrations. (brightsurf.com)
  • Having AFib puts people at an increased risk for stroke, which can be both deadly and costly. (silverbook.org)
  • Long-term exposure to air pollution is already associated with increased risk of cardiovascular death in the general population. (redorbit.com)
  • The existing literature does not focus on risk-taking differences within females and how these differences may influence academic choices in Science, Technology, Engineering, and Mathematics (STEM) fields. (igi-global.com)
  • The current project examined differences in academic risk-taking between STEM and non-STEM female students. (igi-global.com)
  • Results from the first and second studies indicated differences between STEM and non-STEM females in academic risk-taking. (igi-global.com)
  • The corresponding adjusted risk differences were 17 (5 to 36), 32 (21 to 46), 26 (13 to 46), and 77 (49 to 118) cases of major cardiac defects per 1000 infants, respectively. (bmj.com)
  • A project tracking nearly eight million infants born in England and Wales found that exposure to chemicals in the air drove up the risk of death by up to 50 percent. (iol.co.za)
  • Majid Ezzati from the Harvard School of Public Health, Boston, USA, Christopher Murray from WHO, Geneva, Switzerland, and colleagues estimate the potential health benefits from the removal of major risk factors that are associated with the main causes of death and disability worldwide. (innovations-report.com)
  • Heart attack survivors who live about 100 meters (328 feet) or less from a major U.S. roadway face increased risk of death from all causes, according to new research in the American Heart Association's journal Circulation. (redorbit.com)
  • Those living 100 to 199 meters (328 to 653 feet) from the roadway have a 19 percent increased risks of death. (redorbit.com)
  • Those living 200 to 999 meters (653 feet to 3,277 feet) from the roadway have a 13 percent increased risk of death. (redorbit.com)
  • These four health risks are some of the leading causes of death for women worldwide and animal research has played a vital role in helping each one. (fbresearch.org)
  • Researchers are now calling for further studies to understand the mechanisms underlying the association between cardiac-arrest-induced PTSD and the increased risk of a major cardiovascular event or death. (news-medical.net)
  • Kristen Hess and colleagues used HIV diagnosis and death rates from the National HIV Surveillance System, National Center for Health Statistics and population census data to estimate the lifetime risk of being diagnosed with HIV, looking at sub-groups based on sex, age and race/ethnicity, as well as by state. (aidsmap.com)
  • The lifetime risk estimate is the cumulative probability of being diagnosed with HIV from birth to death, assuming diagnosis rates remain constant. (aidsmap.com)
  • In many countries, including the United States, birth defects are the leading cause of infant death and a major contributor to disability and pediatric hospitalizations. (utah.edu)
  • Off-road motor sports had the highest rate of major trauma, including head injury, and death with 119 cases per 100,000 each year, followed by equestrian sports (54), power boating and water skiing (15), and cycling (13). (healthcanal.com)
  • It's important to note that people involved in sport have only a small chance of trauma, injury or death so compared to the health benefits, the risk is considerably low. (healthcanal.com)
  • Fishing had a high death rate but no major injuries. (healthcanal.com)
  • It would be foolish if we didn't consider such accumulating evidence on the health risk of air pollution when going forward in land use planning," Dr Copes added. (medscape.com)
  • The paper examined the health care records of almost 50,000 patients-of whom 6,079 self-identified as black and 43,539 self-identified as white-and compared their algorithmic risk scores with their actual health histories. (scientificamerican.com)
  • When contacted about these results, eight of the top U.S. health insurance companies, as well as two major hospitals and the professional group the Society of Actuaries, declined to comment. (scientificamerican.com)
  • Animal bites therefore represent a major public health problem, largely unrecognized by both the public and governmental officials. (deseretnews.com)
  • Last summer, we compiled a list of the four major health risks for men and animal research's vital role in treating them. (fbresearch.org)
  • Now we want to share with you how animal research has helped treat the top four major health risks for women. (fbresearch.org)
  • The California Major Risk Medical Insurance Program (MRMIP) is a program of the Managed Risk Medical Insurance Board that provides health insurance for Californian citizens who are unable to obtain coverage in the individual health insurance market because of their pre-existing conditions. (wikipedia.org)
  • Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. (clinicaltrials.gov)
  • Complete the following assignment: Take one of the health risk assessments located on the LRC website. (majortests.com)
  • Police declare major incident and risk to public health after hazardous chemical stolen. (theboltonnews.co.uk)
  • Using population-based data from an ongoing, longitudinal survey of health, behavior and disease being carried out by the Icelandic Heart Association, the authors examined the familial risk of smoking in Iceland. (decode.com)
  • Does Fetching Sticks Pose a Major Health Risk to Dogs? (findingdulcinea.com)
  • We used multivariate genecological models to associate population variation with past seed source climates, and to estimate relative risk of maladaptation to current and future climates based on key phenotypic traits and three regional climate projections within the A1B scenario. (usda.gov)
  • She adds that with each new medication, whether prescription, over the counter, and dietary supplement, the risk of adverse reactions, drug interactions or medication errors increases. (go.com)
  • Though the Stability trial was initially designed to assess the risk of adverse CVD events from Darapladib, a lipoprotein inhibitor, the trial also collected dietary information from food frequency questionnaires. (oliveoiltimes.com)
  • According to the results, those who had had surgery had a 40% lower chance of suffering major adverse cardiovascular events over a period of 8 years. (diabetes.co.uk)
  • This finding was replicated in Danish and U.S. cohorts, where the at-risk version of the marker was found to confer an increased risk of 41% and 85%, respectively, per copy carried. (decode.com)
  • We found no association between the "Western" dietary pattern (characterized by such foods as red and processed meats, refined grains, fat, and sweets) or the "healthy" dietary pattern (fruit and vegetables, fish and poultry, low-fat dairy, and whole grains) and breast cancer risk. (aacrjournals.org)
  • Around half (47%) of premature deaths worldwide and around 40% of total disease burden in 2000 resulted from the joint effects of the main risk factors assessed. (innovations-report.com)
  • The worst risks include sea level rise for small islands and coasts, flooding, the breakdown of infrastructure in the face of extreme weather, loss of livelihoods for farmers and fishers, food insecurity and heat-wave deaths. (scientificamerican.com)
  • Occupational risks were estimated with a census-based occupation coding system for cases and deaths, mean annual age-standardized rates, and age-truncated occupation allocation. (nih.gov)
  • But even small reductions in air pollution levels can result in a reduction of disease risk. (brightsurf.com)
  • After a median follow-up of more than four years (51 months), postmenopausal women with hormone-sensitive early breast cancer taking Femara had an 18% reduction in their overall risk of breast cancer recurrence and a 19% reduction in the risk of their cancer spreading to another part of the body. (webwire.com)
  • That sums up a report issued March 31 by the U.N. Intergovernmental Panel on Climate Change (IPCC) about the worsening risks of climate change. (scientificamerican.com)
  • In that light, climate change becomes a risk management proposition, particularly given the uncertainty about exactly how bad impacts might become and when. (scientificamerican.com)
  • Climate change will also raise the risk of conflict , whether civil war or fights between nation states over critical resources or boundaries, according to the new report. (scientificamerican.com)
  • Current risks from climate change were similar to average risks from current seed transfer practices. (usda.gov)
  • Noting that the World Economic Forum's annual Global Risks Report has just been released in Davos, he said that it spotlights climate change mitigation measures as one of the world's top priorities today. (un.org)
  • Noting that today marks the first time that WMO has officially briefed the Council on climate and extreme weather issues, he said climate change affects security in a multitude of ways, rolling back gains in access to food, heightening the risks of wildfire and increasing the potential for water-related conflict. (un.org)
  • The basic ingredient for a successful MHRA is the desire to become more proactive in dealing with the risks associated with events that can cause multiple fatalities. (cdc.gov)
  • Global unpredicted events this year - election results, natural disasters, corporate scandals - have heightened executive and board sensitivity towards risk. (corporatecomplianceinsights.com)
  • The major bleeding events up to 30 days were similar between the low- and standard-dose groups (2.2 percent vs. 1.8 percent)," the researchers write. (medindia.net)
  • This is usually for major tornado outbreaks and occasionally derechos and are typically reserved for the most extreme events. (wikipedia.org)
  • There are exponential opportunities to keep coming up with creative, innovative ways to predict risk, mitigate and underwrite it. (iafrica.com)
  • The highest risk of all was seen in people who lived in an urban environment, close to a major road, and had lived there for a long time. (medscape.com)
  • Analysis of more than 10,000 people by the International Agency for Research on Cancer (IARC) found no relationship between years of use and risk. (bbc.co.uk)
  • In fact, most regular users - defined as people who made use of their phone at least once a week - appeared to have a lower risk of brain cancer than those who rarely used a phone. (bbc.co.uk)
  • Millions of people live in major cities, such as New York, Los Angeles, Tokyo, Delhi and Shanghai, that are situated on fault lines, the researchers noted. (drugs.com)
  • People with lower levels of education and income are more likely to live in communities closer to a major roadway, so they are bearing a larger burden of the risk associated with exposure than people with more resources" said Mittleman, who is also associate professor at Harvard Medical School. (redorbit.com)
  • From an individual point of view, people may lessen the absolute risk of living near a roadway by paying attention to the general prevention measures, including quitting smoking, eating a heart-healthy diet exercising regularly, and keeping blood pressure and cholesterol under control. (redorbit.com)
  • People in risk and insurance underwriting also come from diverse backgrounds which means you'll be blessed to collaborate with fascinating peers from very different fields of expertise so you can consider problems from its many facets," says Shehnaz Somers, Head: Commercial Underwriting at Santam who holds a Masters degree in French Literature. (iafrica.com)
  • The role of risk factors in delayed diagnosis of pulmonary embolism. (medscape.com)
  • These are the first-ever comprehensive national estimates of the lifetime risk of HIV diagnosis for several key populations at risk, according to the CDC. (aidsmap.com)
  • Importantly, the use of Femara resulted in greater disease-free survival in two groups of women who are at particular risk of recurrence - those whose cancer had already spread to the lymph nodes at the time of diagnosis (node positive) and those who had received chemotherapy. (webwire.com)
  • The ten case studies demonstrate that most US mines have the capability to successfully implement an MHRA and that the MHRA methodology produced additional prevention controls and recovery measures to lessen the risk associated with a select population of major mining hazards. (cdc.gov)
  • The overall rate of brain cancer has not risen in countries where use has long been prevalent - like Sweden, and studies have mostly found no evidence of an increased risk. (bbc.co.uk)
  • Largest average risks associated with climate projections for the period 2061-2090 were found for spruce seedling height (0.64), and for beech bud break and leaf senescence (0.52 and 0.46). (usda.gov)
  • Utilizing data from the HapMap project, a SNP was found that correlates nearly perfectly with the at-risk microsatellite. (decode.com)
  • The risks in low- and middle-income countries were mostly identical to the risks found in high-income countries. (brightsurf.com)
  • Marc Melkonian, M.D., from the Hôpitaux Universitaires Pitie-Salpêtrière-Charles Foix in France, and colleagues conducted a systematic review and meta-analysis to evaluate major bleeding in randomized and non-randomized controlled trials (RCTs) and parallel cohorts comparing antiplatelet drugs and oral anticoagulants in patients 65 years or older. (doctorslounge.com)
  • Elderly patients treated with aspirin or clopidogrel suffer less any-severity bleeding but have a risk of major bleeding similar to that of oral anticoagulants, with the exception of intracranial bleeding," the authors write. (doctorslounge.com)