Eosinophil Granule Proteins: Proteins found in EOSINOPHIL granules. They are primarily basic proteins that play a role in host defense and the proinflammatory actions of activated eosinophils.Eosinophil Major Basic Protein: One of several basic proteins released from EOSINOPHIL cytoplasmic granules. Eosinophil major basic protein is a 14-kDa cytotoxic peptide with a pI of 10.9. In addition to its direct cytotoxic effects, it stimulates the release of variety of INFLAMMATION MEDIATORS.Eosinophil-Derived Neurotoxin: A 19-kDa cationic peptide found in EOSINOPHIL granules. Eosinophil-derived neurotoxin is a RIBONUCLEASE and may play a role as an endogenous antiviral agent.Eosinophil Peroxidase: A 66-kDa peroxidase found in EOSINOPHIL granules. Eosinophil peroxidase is a cationic protein with a pI of 10.8 and is comprised of a heavy chain subunit and a light chain subunit. It possesses cytotoxic activity towards BACTERIA and other organisms, which is attributed to its peroxidase activity.Eosinophils: Granular leukocytes with a nucleus that usually has two lobes connected by a slender thread of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and stainable by eosin.Ribonucleases: Enzymes that catalyze the hydrolysis of ester bonds within RNA. EC 3.1.-.Blood Proteins: Proteins that are present in blood serum, including SERUM ALBUMIN; BLOOD COAGULATION FACTORS; and many other types of proteins.Eosinophil Cationic Protein: One of several basic proteins released from EOSINOPHIL cytoplasmic granules. Eosinophil cationic protein is a 21-kDa cytotoxic peptide with a pI of 10.9. Although eosinophil cationic protein is considered a member of the RNAse A superfamily of proteins, it has only limited RNAse activity.Cytoplasmic Granules: Condensed areas of cellular material that may be bounded by a membrane.Eosinophilia: Abnormal increase of EOSINOPHILS in the blood, tissues or organs.PeroxidasesInterleukin-5: A cytokine that promotes differentiation and activation of EOSINOPHILS. It also triggers activated B-LYMPHOCYTES to differentiate into IMMUNOGLOBULIN-secreting cells.Secretory Vesicles: Vesicles derived from the GOLGI APPARATUS containing material to be released at the cell surface.Cell Degranulation: The process of losing secretory granules (SECRETORY VESICLES). This occurs, for example, in mast cells, basophils, neutrophils, eosinophils, and platelets when secretory products are released from the granules by EXOCYTOSIS.Neurotoxins: Toxic substances from microorganisms, plants or animals that interfere with the functions of the nervous system. Most venoms contain neurotoxic substances. Myotoxins are included in this concept.Receptors, Leukotriene: Cell-surface receptors that bind LEUKOTRIENES with high affinity and trigger intracellular changes influencing the behavior of cells. The leukotriene receptor subtypes have been tentatively named according to their affinities for the endogenous leukotrienes LTB4; LTC4; LTD4; and LTE4.Neutrophils: Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.Guinea Pigs: A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.Microscopy, Electron: Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.Lactoferrin: An iron-binding protein that was originally characterized as a milk protein. It is widely distributed in secretory fluids and is found in the neutrophilic granules of LEUKOCYTES. The N-terminal part of lactoferrin possesses a serine protease which functions to inactivate the TYPE III SECRETION SYSTEM used by bacteria to export virulence proteins for host cell invasion.Pregnancy-Associated Plasma Protein-A: A product of the PLACENTA, and DECIDUA, secreted into the maternal circulation during PREGNANCY. It has been identified as an IGF binding protein (IGFBP)-4 protease that proteolyzes IGFBP-4 and thus increases IGF bioavailability. It is found also in human FIBROBLASTS, ovarian FOLLICULAR FLUID, and GRANULOSA CELLS. The enzyme is a heterotetramer of about 500-kDa.Chemotactic Factors, Eosinophil: Cytotaxins liberated from normal or invading cells that specifically attract eosinophils; they may be complement fragments, lymphokines, neutrophil products, histamine or other; the best known is the tetrapeptide ECF-A, released mainly by mast cells.Paracoccidioides: A mitosporic fungal genus. P. brasiliensis (previously Blastomyces brasiliensis) is the etiologic agent of PARACOCCIDIOIDOMYCOSIS.Paracoccidioidomycosis: A mycosis affecting the skin, mucous membranes, lymph nodes, and internal organs. It is caused by Paracoccidioides brasiliensis. It is also called paracoccidioidal granuloma. Superficial resemblance of P. brasiliensis to Blastomyces brasiliensis (BLASTOMYCES) may cause misdiagnosis.Globins: A superfamily of proteins containing the globin fold which is composed of 6-8 alpha helices arranged in a characterstic HEME enclosing structure.Atlantic Islands: Widely scattered islands in the Atlantic Ocean as far north as the AZORES and as far south as the South Sandwich Islands, with the greatest concentration found in the CARIBBEAN REGION. They include Annobon Island, Ascension, Canary Islands, Falkland Islands, Fernando Po (also called Isla de Bioko and Bioko), Gough Island, Madeira, Sao Tome and Principe, Saint Helena, and Tristan da Cunha.Sugar Alcohol Dehydrogenases: Reversibly catalyzes the oxidation of a hydroxyl group of sugar alcohols to form a keto sugar, aldehyde or lactone. Any acceptor except molecular oxygen is permitted. Includes EC 1.1.1.; EC 1.1.2. and EC 1.1.99.ParaguayBile: An emulsifying agent produced in the LIVER and secreted into the DUODENUM. Its composition includes BILE ACIDS AND SALTS; CHOLESTEROL; and ELECTROLYTES. It aids DIGESTION of fats in the duodenum.Mast Cells: Granulated cells that are found in almost all tissues, most abundantly in the skin and the gastrointestinal tract. Like the BASOPHILS, mast cells contain large amounts of HISTAMINE and HEPARIN. Unlike basophils, mast cells normally remain in the tissues and do not circulate in the blood. Mast cells, derived from the bone marrow stem cells, are regulated by the STEM CELL FACTOR.ArgentinaHistiocytic Necrotizing Lymphadenitis: Development of lesions in the lymph node characterized by infiltration of the cortex or paracortex by large collections of proliferating histiocytes and complete or, more often, incomplete necrosis of lymphoid tissue.Work of Breathing: RESPIRATORY MUSCLE contraction during INHALATION. The work is accomplished in three phases: LUNG COMPLIANCE work, that required to expand the LUNGS against its elastic forces; tissue resistance work, that required to overcome the viscosity of the lung and chest wall structures; and AIRWAY RESISTANCE work, that required to overcome airway resistance during the movement of air into the lungs. Work of breathing does not refer to expiration, which is entirely a passive process caused by elastic recoil of the lung and chest cage. (Guyton, Textbook of Medical Physiology, 8th ed, p406)Allergy and Immunology: A medical specialty concerned with the hypersensitivity of the individual to foreign substances and protection from the resultant infection or disorder.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Journal Impact Factor: A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.Serotonin Plasma Membrane Transport Proteins: Sodium chloride-dependent neurotransmitter symporters located primarily on the PLASMA MEMBRANE of serotonergic neurons. They are different than SEROTONIN RECEPTORS, which signal cellular responses to SEROTONIN. They remove SEROTONIN from the EXTRACELLULAR SPACE by high affinity reuptake into PRESYNAPTIC TERMINALS. Regulates signal amplitude and duration at serotonergic synapses and is the site of action of the SEROTONIN UPTAKE INHIBITORS.Publishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.Hypereosinophilic Syndrome: A heterogeneous group of disorders with the common feature of prolonged eosinophilia of unknown cause and associated organ system dysfunction, including the heart, central nervous system, kidneys, lungs, gastrointestinal tract, and skin. There is a massive increase in the number of EOSINOPHILS in the blood, mimicking leukemia, and extensive eosinophilic infiltration of the various organs.Myeloproliferative Disorders: Conditions which cause proliferation of hemopoietically active tissue or of tissue which has embryonic hemopoietic potential. They all involve dysregulation of multipotent MYELOID PROGENITOR CELLS, most often caused by a mutation in the JAK2 PROTEIN TYROSINE KINASE.Gnathostomiasis: Infections with nematodes of the genus GNATHOSTOMA, superfamily THELAZIOIDEA. Gnathostomiasis is a food-borne zoonosis caused by eating undercooked or raw fish or meat.Syndrome: A characteristic symptom complex.Receptor, Platelet-Derived Growth Factor alpha: A PDGF receptor that binds specifically to both PDGF-A chains and PDGF-B chains. It contains a protein-tyrosine kinase activity that is involved in SIGNAL TRANSDUCTION.Dictionaries, MedicalAsthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).Anti-Asthmatic Agents: Drugs that are used to treat asthma.Biological Markers: Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.Rubber: A high-molecular-weight polymeric elastomer derived from the milk juice (LATEX) of HEVEA brasiliensis and other trees and plants. It is a substance that can be stretched at room temperature to at least twice its original length and after releasing the stress, retract rapidly, and recover its original dimensions fully.Administration, Inhalation: The administration of drugs by the respiratory route. It includes insufflation into the respiratory tract.Adrenal Cortex HormonesPeak Expiratory Flow Rate: Measurement of the maximum rate of airflow attained during a FORCED VITAL CAPACITY determination. Common abbreviations are PEFR and PFR.
Cardiac damage caused by the damaging effects of eosinophil granule proteins (ex. major basic protein) is known as Loeffler ... Löffler's syndrome or Loeffler's syndrome is a disease in which eosinophils accumulate in the lung in response to a parasitic ...
... and C/EBPepsilon isoforms regulate transcription of the gene encoding eosinophil granule major basic protein". The Journal of ... CCAAT/enhancer binding protein (C/EBP), epsilon, also known as CEBPE and CRP1, is a type of ccaat-enhancer-binding protein. ... It can also form heterodimers with the related protein CEBP-δ. The encoded protein may be essential for terminal ... "Regulation of neutrophil and eosinophil secondary granule gene expression by transcription factors C/EBP epsilon and PU.1". ...
... excess eosinophil-specific granule proteins (such as major basic protein, erythropoietin and eosinophil cationic protein) on ... In addition, Protein C is inhibited by protein C inhibitor. Protein C is a major component in anticoagulation in the human body ... Slungaard A, Vercellotti GM, Tran T, Gleich GJ, Key NS (April 1993). "Eosinophil cationic granule proteins impair ... In addition, proteins released from cells can impede protein C activation, for example eosinophil, which may explain thrombosis ...
"Eosinophil granule cationic proteins: major basic protein is distinct from the smaller subunit of eosinophil peroxidase". J. ... eosinophil granule major basic protein), also known as PRG2, is a protein which in humans is encoded by the PRG2 gene. The ... 1990). "Evidence of eosinophil granule major basic protein in human placenta". J. Exp. Med. 170 (6): 2051-2063. doi:10.1084/jem ... Barker RL, Gleich GJ, Pease LR (1988). "Acidic precursor revealed in human eosinophil granule major basic protein cDNA". J. Exp ...
"Eosinophil granule cationic proteins: major basic protein is distinct from the smaller subunit of eosinophil peroxidase". J. ... 1990). "Evidence of eosinophil granule major basic protein in human placenta". J. Exp. Med. 170 (6). ss. 2051-2063. doi:10.1084 ... "Eosinophil-granule major basic protein, a C-type lectin, binds heparin". Biochemistry. 44 (43). Kasım 2005. ss. 14152-14158.. ... 1988). "Biochemical and amino acid sequence analysis of human eosinophil granule major basic protein". J. Biol. Chem. 263 (25 ...
... colocalization of pregnancy-associated plasma protein-A messenger ribonucleic acid and eosinophil granule major basic protein ... "Complex of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein. Disulfide structure and ... "Messenger ribonucleic acid levels of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein: ... "Circulating human pregnancy-associated plasma protein-A is disulfide-bridged to the proform of eosinophil major basic protein ...
These include: major basic protein (MBP) eosinophil cationic protein (ECP) eosinophil peroxidase (EPX) eosinophil-derived ... Eosinophils produce and store many secondary granule proteins prior to their exit from the bone marrow. After maturation, ... Major basic protein, eosinophil peroxidase, and eosinophil cationic protein are toxic to many tissues. Eosinophil cationic ... High concentrations of eosinophil major basic protein and eosinophil-derived neurotoxin that approach cytotoxic levels are ...
NADPH oxidase Eosinophil: cathepsin, major basic protein Basophil: heparin, histamine (not directly cytotoxic) A specific ... Specific granules are also known as "secondary granules". Examples of cytotoxic molecule stored by specific granules in ... Online Mendelian Inheritance in Man (OMIM) SPECIFIC GRANULE DEFICIENCY; SGD -245480 Neutrophil granules at sav.sk. ... "Ultrastructural study of the specific granule of the human eosinophil". J. Submicrosc. Cytol. 13 (3): 465-71. PMID 7334549. ...
Eosinophil Major basic protein Secretory pathway Peroxiredoxin Catalase Reactive oxygen species Antimicrobial peptides The ... Subsequently eosinophil peroxidase was found to be localized to primary and secondary granules of the eosinophil. Eosinophils ... The protein is concentrated in secretory granules within eosinophils. Eosinophil peroxidase is a heme peroxidase, its ... and the post-translational modification of protein amino acid residues. The major function of eosinophil peroxidase is to ...
In a similar mechanism, activated eosinophils release preformed mediators such as major basic protein, and enzymes such as ... specific granules, and azurophil granules. Cytotoxic T cells and NK cells release molecules like perforin and granzymes by a ... Four kinds of granules exist in neutrophils that display differences in content and regulation. Secretory vesicles are the most ... Capron M, Soussi Gounni A, Morita M, Truong M, Prin L, Kinet J, Capron A (1995). "Eosinophils: from low- to high-affinity ...
"Antibacterial properties of eosinophil major basic protein and eosinophil cationic protein". Journal of Immunology. 142 (12): ... Eosinophil cationic protein is localized to the granule matrix of the eosinophil. The ribonuclease activity of ECP is not ... Eosinophil Cationic Protein (ECP) also known as ribonuclease 3 is a basic protein located in the eosinophil primary matrix. In ... ECP is one of the four highly basic proteins that enter the surrounding tissues when activated eosinophils degranulate. ...
Eosinophils, like other granulocytes, contain granules (or sacs) filled with digestive enzymes and cytotoxic proteins which ... This process is generally accepted to be the major inflammatory process in the pathophysiology of atopic or allergic asthma. ... "Table 12-6". Robbins Basic Pathology (8th ed.). Philadelphia: Saunders. ISBN 1-4160-2973-7. Boyer DF (2016). "Blood and Bone ... the granules in eosinophils also contain inflammatory molecules and cytokines which can recruit more eosinophils and other ...
The nucleus is bi- or tri-lobed, but it is hard to see because of the number of coarse granules that hide it. They excrete two ... There are four major causes: increase of production in bone marrow, increased release from storage in bone marrow, decreased ... Eosinophils compose about 2-4% of the WBC total. This count fluctuates throughout the day, seasonally, and during menstruation ... It also makes blood vessels more permeable so neutrophils and clotting proteins can get into connective tissue more easily. ...
Eosinophil. *Cathepsin. *Major basic protein. *Eosinophil cationic protein. *Eosinophil peroxidase. *Eosinophil-derived ... Dense granules play a major roll in Toxoplasma gondii. When the parasite invades it releases its dense granules which help to ... Dense granules (also known as dense bodies or delta granules) are specialized secretory organelles. Dense granules are found ... There are a number of proteins that are within the dense granule membrane. To maintain the low pH within the granule, there is ...
Activated eosinophils release preformed mediators such as major basic protein, and enzymes such as peroxidase, against which ... cells stimulate the NK cells to release cytotoxic molecules from their granules to kill antibody-covered target cells. FcεRI ... eosinophils, mast cells and basophils. As a result of its cellular distribution, this receptor plays a major role in ... This adaptor protein is called the Fcγ subunit and, like FcγRIIA, contains the two YXXL sequences that are characteristic of an ...
The recruited eosinophils will degranulate releasing a number of cytotoxic molecules (including Major Basic Protein and ... The reaction is caused by the release of histamine and mast cell granule proteins by a process called degranulation, as well as ... cells are typically of the Th2 variety and the cytokines they produce lead to further recruitment of mast cells and eosinophils ... eosinophil peroxidase) as well as produce a number of cytokines such as IL-5. The recruited T- ...
Upon activation, eosinophils secrete a range of highly toxic proteins and free radicals that are highly effective in killing ... The major functions of the vertebrate innate immune system include: Recruiting immune cells to sites of infection through the ... Neutrophil granules contain a variety of toxic substances that kill or inhibit growth of bacteria and fungi. Similar to ... In Lotze MT & Thompson AW (eds): Natural killer cells - Basic Science and Clinical applications 2010; pp169 - 75 Tracey, KJ ( ...
"Comparative properties of the Charcot-Leyden crystal protein and the major basic protein from human eosinophils". J. Clin. ... to granules and intragranular crystals in mature human basophils". Lab. Invest. 60 (4): 557-67. doi:10.1111/1523-1747. ... eosinophil-derived neurotoxin) and ribonuclease 3 (eosinophil cationic protein) genes (RNS2 and RNS3) to chromosome 14". ... The protein encoded by this gene is a lysophospholipase expressed in eosinophils and basophils. It hydrolyzes ...
Eosinophil. *Cathepsin. *Major basic protein. *Eosinophil cationic protein. *Eosinophil peroxidase. *Eosinophil-derived ... specific granule. • intracellular. • extracellular exosome. • extracellular space. • specific granule lumen. • tertiary granule ... a cathelin/pro-bactenecin-like protein of human neutrophil specific granules". FEBS Letters. 368 (1): 173-6. doi:10.1016/0014- ... Patients with a high level of this protein were 3.7 times more likely to survive kidney dialysis for a year without a fatal ...
Eosinophil. *Cathepsin. *Major basic protein. *Eosinophil cationic protein. *Eosinophil peroxidase. *Eosinophil-derived ... 1993). "Eosinophil granule proteins in peripheral blood granulocytes". J. Leukoc. Biol. 52 (6): 611-8. doi:10.1002/jlb.52.6.611 ... The protein encoded by this gene is found in eosinophil granulocytes. It is closely related to the eosinophil cationic protein ... 1989). "Eosinophil cationic protein cDNA. Comparison with other toxic cationic proteins and ribonucleases". J. Immunol. 143 (3 ...
Activated eosinophils release preformed mediators such as major basic protein, and enzymes such as peroxidase, against which ... 1 = antigen; 2 = IgE; 3 = FcεRI; 4 = preformed mediators (histamine, proteases, chemokines, heparin); 5 = granules; 6 - mast ... Eosinophils. Platelets. Langerhans cells Phagocytosis. Degranulation (eosinophils) FcγRIIB1 (CD32) IgG Low (Kd , 10−7 M) B ... eosinophils, mast cells and basophils.[13][14] As a result of its cellular distribution, this receptor plays a major role in ...
"The major human erythroid DNA-binding protein (GF-1): primary sequence and localization of the gene to the X chromosome". ... "Expression of mRNA for the GATA-binding proteins in human eosinophils and basophils: potential role in gene transcription". ... Alpha-granules contain various factors which contribute to blood clotting and other functions. In their absence, platelets are ... Fujiwara T (June 2017). "GATA Transcription Factors: Basic Principles and Related Human Disorders". The Tohoku Journal of ...
Eosinophil. Main article: Eosinophil. Eosinophils compose about 2-4% of the WBC total. This count fluctuates throughout the day ... Wheater PR, Stevens A (2002). Wheater's basic histopathology: a colour atlas and text (PDF). Edinburgh: Churchill Livingstone. ... Major surgery. *Miscellaneous - ECMO, kidney or bone marrow transplant, hemodialysis, kidney failure, severe burn, celiac ... The lobes are connected by a thin strand.[9] The cytoplasm is full of granules that assume a characteristic pink-orange color ...
... protein G), Staphylococcus aureus (protein A), and Peptostreptococcus magnus (protein L). The mechanisms used to evade the ... receptor called a major histocompatibility complex (MHC) molecule. There are two major subtypes of T cells: the killer T cell ... Other basic immune mechanisms evolved in ancient eukaryotes and remain in their modern descendants, such as plants and ... Basophils and eosinophils are related to neutrophils. They secrete chemical mediators that are involved in defending against ...
Setelah protein komplemen terikat pada mikroba, protein-protein ini mengaktifkan aktivitas proteasenya, yang kemudian ... Major Walter Reed, Medical Corps, U.S. Army Walter Reed Army Medical Center. Diakses 8 Januari 2007. ... Radoja S, Frey A, Vukmanovic S (2006). "T-cell receptor signaling events triggering granule exocytosis". Crit Rev Immunol. 26 ( ... Kariyawasam H, Robinson D (2006). "The eosinophil: the cell and its weapons, the cytokines, its locations". Semin Respir Crit ...
Eosinophil. Main article: Eosinophil. Eosinophils compose about 2-4% of the WBC total. This count fluctuates throughout the day ... Wheater PR, Stevens A (2002). Wheater's basic histopathology: a colour atlas and text (PDF). Edinburgh: Churchill Livingstone. ... Major surgery. *Miscellaneous - ECMO, kidney or bone marrow transplant, hemodialysis, kidney failure, severe burn, celiac ... The lobes are connected by a thin strand.[9] The cytoplasm is full of granules that assume a characteristic pink-orange color ...
These observations support the hypothesis that the eosinophil, through toxic granule proteins such as major basic protein, ... The eosinophil granule major basic protein is toxic to helminths and mammalian cells in vitro, and its release has been used as ... all tissues were stained with polyclonal antibody to major basic protein; subsequently, colocalization of major basic protein ... using the polyclonal anti-major basic protein antibody, nine of nine tissues showed extracellular major basic protein ...
Eosinophil major basic protein, proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic ... Proteoglycan 2 (PRG2, also known as eosinophil major basic protein) is a protein encoded by this gene as the predominant ... Application of monoclonal antibodies against major basic protein (BMK-13) and eosinophil cationic protein (EG1 and EG2) for ... Antibody for PRG2 (Eosinophil Major Basic Protein) [BMK-13]. Monoclonal antibody detecting PRG2, raised in mice. ...
Human eosinophil-granule major basic protein and synthetic polycations induce airway hyperresponsiveness in vivo dependent on ... Human eosinophil-granule major basic protein and synthetic polycations induce airway hyperresponsiveness in vivo dependent on ... we investigated the role of bradykinin in airway hyperresponsiveness induced by human eosinophil-granule major basic protein ( ... an effect that may be related to the cationic charge of these proteins. Furthermore, the ability of these proteins to increase ...
Human eosinophil-granule major basic protein and synthetic polycations induce airway hyperresponsiveness in vivo dependent on ... we investigated the role of bradykinin in airway hyperresponsiveness induced by human eosinophil-granule major basic protein ( ... an effect that may be related to the cationic charge of these proteins. Furthermore, the ability of these proteins to increase ... determine whether kinin production is required for the development of airway hyperresponsiveness induced by cationic proteins, ...
C/EBPβ and GATA-1 synergistically regulate activity of the eosinophil granule major basic protein promoter: Implication for C/ ... C/EBPβ and GATA-1 synergistically regulate activity of the eosinophil granule major basic protein promoter: Implication for C/ ... EBPβ activity in eosinophil gene expression. Together they form a unique fingerprint. * Sort by ...
Cardiac localization of eosinophil-granule major basic protein in acute necrotizing myocarditis ... Cardiac localization of eosinophil-granule major basic protein in acute necrotizing myocarditis. Article Abstract:. ... A role for the major basic protein of eosinophil granules has been suggested in Lofflers endomyocarditis, a mild and transient ... Recent research has concentrated on major basic protein, a component of eosinophil granules, which is toxic in high ...
... s, commonly referred to as eosinophils (or less commonly as acidophils), are white blood cells of the ... Major basic protein, eosinophil peroxidase, and eosinophil cationic protein are toxic to many tissues.[11] Eosinophil cationic ... Eosinophil granule proteins. Following activation by an immune stimulus, eosinophils degranulate to release an array of ... such as histamine and proteins such as eosinophil peroxidase, RNase, DNases, lipase, plasminogen, and Major Basic Protein. ...
Major basic protein, eosinophil peroxidase, and eosinophil cationic protein are toxic to many tissues.[11] Eosinophil cationic ... Eosinophil granule proteins. Following activation by an immune stimulus, eosinophils degranulate to release an array of ... such as histamine and proteins such as eosinophil peroxidase, RNase, DNases, lipase, plasminogen, and Major Basic Protein. ... protein and eosinophil-derived neurotoxin are ribonucleases with antiviral activity.[14] Major basic protein induces mast cell ...
Acidic precursor revealed in human eosinophil granule major basic protein cDNA.. Eosinophil granule major basic protein (MBP), ... Acidic precursor revealed in human eosinophil granule major basic protein cDNA. Barker, R.L., Gleich, G.J., Pease, L.R. J. Exp ... eosinophil from damage while the protein is processed through the endoplasmic reticulum to its sequestered site in the granule ... wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary ...
Eosinophil Granule Major Basic Protein, Tissue. Example Report. 2010902. Epidermal Transglutaminase (etG/tTG3) Antibody, IgA by ... Protein Electrophoresis with Reflex to Immunofixation Electrophoresis Monoclonal Protein Detection, Quantitation & ... Bence Jones Protein, Quantitation and Characterization, with Reflex to Kappa/Lambda Free Light Chains with Ratio, Urine. ... Monoclonal Protein Detection Quantitation and Characterization, SPEP, IFE, IgA, IgG, IgM, Serum. Example Report. ...
"Eosinophil granule cationic proteins: major basic protein is distinct from the smaller subunit of eosinophil peroxidase". J. ... 1990). "Evidence of eosinophil granule major basic protein in human placenta". J. Exp. Med. 170 (6). ss. 2051-2063. doi:10.1084 ... "Eosinophil-granule major basic protein, a C-type lectin, binds heparin". Biochemistry. 44 (43). Kasım 2005. ss. 14152-14158.. ... 1988). "Biochemical and amino acid sequence analysis of human eosinophil granule major basic protein". J. Biol. Chem. 263 (25 ...
With immunofluorescent stains, eosinophil major basic protein is identified in the granules of the flame figures. On electron ... Immunofluorescence identification of eosinophil granule major basic protein in the flame figures of Wells syndrome. Br J ... eosinophil levels, eosinophil cation protein and interleukin-5. Br J Dermatol. 1999 Jan. 140(1):127-30. [Medline]. ... 8] A dermal infiltrate of histiocytes, eosinophils, and eosinophilic granules occurs between collagen bundles, which forms the ...
"Eosinophil granule cationic proteins: major basic protein is distinct from the smaller subunit of eosinophil peroxidase". J. ... eosinophil granule major basic protein), also known as PRG2, is a protein which in humans is encoded by the PRG2 gene. The ... 1990). "Evidence of eosinophil granule major basic protein in human placenta". J. Exp. Med. 170 (6): 2051-2063. doi:10.1084/jem ... Barker RL, Gleich GJ, Pease LR (1988). "Acidic precursor revealed in human eosinophil granule major basic protein cDNA". J. Exp ...
Immunofluorescent localization of eosinophil granule major basic protein in fatal human cases of Baylisascaris procyonis ...
Expression, purification, and characterization of the recombinant proform of eosinophil granule major basic protein. P Popken- ... Latent membrane protein-1 induces cyclin D2 expression, pRb hyperphosphorylation, and loss of TGF-beta 1-mediated growth ... Identification of recombinant filarial proteins capable of inducing polyclonal and antigen-specific IgE and IgG4 antibodies. O ... Macrophage inflammatory protein-1 alpha mediates lung leukocyte recruitment, lung capillary leak, and early mortality in murine ...
These toxins include major basic protein, eosinophil peroxidase, eosinophil-derived neurotoxin, and eosinophil cationic protein ... Eosinophil granules contain toxic cationic proteins, which are the primary mediators of tissue damage. ... Only eosinophils and basophils and their precursors have receptors for IL-3, IL-5, and GM-CSF. In vitro, eosinophils survive ... Eosinophils amplify the inflammatory cascade by secreting chemoattractants that recruit more eosinophils. Such chemoattractants ...
Interestingly, his BAL eosinophils showed intact granules containing major basic protein on transmission electron microscopy. ... the granules are empty and major basic protein has been extruded [29]. This contributes to high oxidant stress in the terminal ... eosinophils recovered in BAL [29]. Transmission EM showed marked loss of granule content and disappearance of dense central ... Interestingly, the four major inflammatory cytokines IL-1β, IL-6, IL-8, and TNF-α all have NF-κB and C/EBPβ sites in their ...
... major basic protein explanation free. What is major basic protein? Meaning of major basic protein medical term. What does major ... Looking for online definition of major basic protein in the Medical Dictionary? ... Acidic precursor revealed in human eosinophil granule major basic protein cDNA.. Expression of eosinophil-granule major basic ... a cytotoxic and proinflammatory mediator found in eosinophil granules.. major basic protein. An 11-kD major cytotoxic and ...
Dor PJ, Ackerman SJ, Gleich GJ (1984) Charcot-Leyden crystal protein and eosinophil granule major basic protein in sputum of ... Frigas E, Loegering DA, Solley GO, Farrow GM, Gleich GJ (1981) Elevated levels of the eosinophil granule major basic protein in ... Ackerman SJ, Kephart GM, Habermann TM, Greipp PR, Gleich GJ (1983) Localisation of eosinophil granule major basic protein in ... Eosinophil-derived products, particularly eosinophil granule proteins, have been investigated as markers of eosinophil ...
Cardiac damage caused by the damaging effects of eosinophil granule proteins (ex. major basic protein) is known as Loeffler ... Löfflers syndrome or Loefflers syndrome is a disease in which eosinophils accumulate in the lung in response to a parasitic ...
Wasmoen et al., "Biochemical and Amino Acid Sequence Analysis of Human Eosinophil Granule Major Basic Protein," J. Biol. Chem ... Ohlsson et al., "A beta-cell-specific protein binds to the two major regulatory sequences of the insulin gene enhancer," Proc. ... The E1a region contains the major transcriptional activators, such as the major late promoter (MLP). Id. at 616. The E1a region ... 255:6947-6953, 1980), pokeweed antiviral protein (Irvin, Pharmac. Ther. 21:371-387,1983), antiviral protein (Barbieri et al., ...
A novel and highly divergent homolog of human eosinophil granule major basic protein. Plager, D.A., Loegering, D.A., Weiler, D. ... An ATPase domain common to prokaryotic cell cycle proteins, sugar kinases, actin, and hsp70 heat shock proteins. Bork, P., ... hMBPH was isolated from human eosinophil granule lysates, and its identity was verified by amino acid sequencing and by mass ... The 220-kDa rim protein of retinal rod outer segments is a member of the ABC transporter superfamily. Illing, M., Molday, L.L ...
Eosinophils are bone marrow-derived cells that differentiate in the bone marrow and migrate into the peripheral blood primarily ... Deposition of eosinophil granule major basic protein in eosinophil gastroenteritis and celiac disease. Gastroenterology, 102, ... Activation of basophil and mast cell histamine release by eosinophil granule major basic protein. Journal of Experimental ... derived mast cells is induced by eosinophil major basic protein and modulated by the membrane form of stem cell factor. Blood, ...
Activation of basophil and mast cell histamine release by eosinophil granule major basic protein. J Exp Med. 1983 Jun 1;157(6): ... MMastocytes and basophils are activated and release histamine upon stimulation by eosinophil-derived cationic granule proteins ... Total proteins (g/dL). 7.3 (7.1-7.4)(n=40). 7.0 (6.4-7.7)(n=6). 7.3 (7.1-7.4)(n=14). 7.0 (6.4-7.7)(n=3). 7.0 (6.4-7.7)(n=15). ... Total proteins (g/dL). 7.2 (6.9-7.4)(n=18 ). 7.3 (7.1-7.4)£ (n=46 ). 7.7 (7.3-7.9)+ (n=13 ). 7.4 (7.1-7.6) (n=15 ). ...
Identification of a major basic protein in guinea pig eosinophil granules, J. Exp. Med. 137:1459.PubMedCrossRefGoogle Scholar ... Destruction of bloodstream forms of Trypanosoma cruzi by eosinophil granule major basic protein, Am. J. Trop. Med. Hyg. 30:775. ... Physicochemical and biological properties of the major basic protein from guinea pig eosinophil granules, J. Exp. Med. 140:313. ... Comparative properties of the Charcot-Leyden crystal protein and the major basic protein from human eosinophils, J. Clin. ...
  • MBP, ECP, EPO, and arylsulfatase B were observed in both coreless and core-containing (specific) granules. (lu.se)
  • The difference in the distribution of MBP, having a uniform distribution in coreless granules and a crystalloid distribution in core-containing (specific) granules, could indicate a maturational process of a common organelle. (lu.se)
  • The present findings suggest that coreless granules develop into core-containing specific granules. (lu.se)
  • De Duve C, Masson P. L, Heremans J. F. Association of lactoferrin with specific granules in rabbit heterophil leukocytes U J.Exp. (bio-cat.ru)
  • G. Differences in enzyme content of azurophil and specific granules of polymorphonuclear leukocytes J. Cell Biol. (bio-cat.ru)
  • Origin and content of azurophil and specific granules H J. Exp. (bio-cat.ru)
  • b)Basophilic myelocyte & metamyelocyte-Specific granules start to appear in the myelocyte stage, and as the cell develops into the metamyelocyte stage, mitosis ceases. (hubpages.com)
  • b)Eosinophilic myelocyte & metamyelocyte-Specific granules start to appear in the myelocyte stage and once the cell has reached the metamyelocyte stage it cannot undergo further mitosis. (hubpages.com)
  • Although eosinophils have long been associated with the immune defense against helminths, the role of eosinophils in the immune response to fungal diseases is not as well studied. (ajtmh.org)
  • Dualistic role of eosinophils might be attributed to the fact that eosinophils have direct and indirect tumoricidal activity as well as, they may promote tumor angiogenesis via production of se-veral angiogenic factors . (exp-oncology.com.ua)
  • Monoclonal antibodies against the complex of human pregnancy-associated plasma protein-A and the proform of eosin ophil major basic protein (PAPP-A/proMBP-complex): production, characterization, epitope analysis and application in immunochemical assays for PAPP-A/proMBP-complex [Abstract]. (thefreedictionary.com)
  • Complement activation results in the production of several chemotactic factors, such as component C5a, so the activation of eosinophils might be one of its consequences . (bio-zentrum.com)
  • What issues are most important to consider when evaluating a patient with a possible eosinophil-related disorder? (arupconsult.com)
  • What issues are important when evaluating pediatric patients with possible eosinophil-related disorders? (arupconsult.com)
  • CLC protein was distributed in the cytosol, in the euchromatin of the nuclei, but was also present in a rare granular compartment of both immature and mature eosinophils. (lu.se)
  • Aalbers, R, de Monchy JGR, Kaufman HF, Smith M, Hoekstra, Vrugt B, Timens W (1993) Dynamics of eosinophil infiltration in the bronchial mucosa before and after the late asthmatic reaction Eur Respir J 6:840-847. (springer.com)